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https://www.readbyqxmd.com/read/27903793/the-serotonin-5-ht2c-receptor-and-the-non-addictive-nature-of-classic-hallucinogens
#1
REVIEW
Clinton E Canal, Kevin S Murnane
Classic hallucinogens share pharmacology as serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptor agonists. Unique among most other Schedule 1 drugs, they are generally non-addictive and can be effective tools in the treatment of addiction. Mechanisms underlying these attributes are largely unknown. However, many preclinical studies show that 5-HT2C agonists counteract the addictive effects of drugs from several classes, suggesting this pharmacological property of classic hallucinogens may be significant. Drawing from a comprehensive analysis of preclinical behavior, neuroanatomy, and neurochemistry studies, this review builds rationale for this hypothesis, and also proposes a testable, neurobiological framework...
November 15, 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27896312/the-memory-trace-supporting-lose-shift-responding-decays-rapidly-after-reward-omission-and-is-distinct-from-other-learning-mechanisms-in-rats
#2
Aaron J Gruber, Rajat Thapa
The propensity of animals to shift choices immediately after unexpectedly poor reinforcement outcomes is a pervasive strategy across species and tasks. We report here that the memory supporting such lose-shift responding in rats rapidly decays during the intertrial interval and persists throughout training and testing on a binary choice task, despite being a suboptimal strategy. Lose-shift responding is not positively correlated with the prevalence and temporal dependence of win-stay responding, and it is inconsistent with predictions of reinforcement learning on the task...
November 2016: ENeuro
https://www.readbyqxmd.com/read/27867436/putamen-activation-represents-an-intrinsic-positive-prediction-error-signal-for-visual-search-in-repeated-configurations
#3
Susanne Sommer, Stefan Pollmann
We investigated fMRI responses to visual search targets appearing at locations that were predicted by the search context. Based on previous work in visual category learning we expected an intrinsic reward prediction error signal in the putamen whenever the target appeared at a location that was predicted with some degree of uncertainty. Comparing target appearance at locations predicted with 50% probability to either locations predicted with 100% probability or unpredicted locations, increased activation was observed in left posterior putamen and adjacent left posterior insula...
2016: Open Neuroimaging Journal
https://www.readbyqxmd.com/read/27865452/cyp2a6-genetic-variation-alters-striatal-cingulate-circuits-network-hubs-and-executive-processing-in-smokers
#4
Sufang Li, Yihong Yang, Ewa Hoffmann, Rachel F Tyndale, Elliot A Stein
BACKGROUND: Variation in the CYP2A6 gene alters the rate of nicotine metabolic inactivation and is associated with smoking behaviors and cessation success rates. The underlying neurobiological mechanisms of this genetic influence are unknown. METHODS: Intrinsic functional connectivity strength, a whole-brain, data-driven, graph theory-based method, was applied to resting-state functional magnetic resonance imaging data in 66 smokers and 92 nonsmokers. A subset of subjects (n = 23/20; smokers/nonsmokers) performed the monetary incentive delay task, probing reward anticipation, and a go/no-go task, probing response inhibition, on two occasions, in the presence and absence of a nicotine patch...
September 28, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27852199/paying-hospitals-for-quality-can-we-buy-better-care
#5
Jane P Hall, Kees C van Gool
Economic theory predicts that changing financial rewards will change behaviour. This is valid in terms of service use; higher costs reduce health care use. It should follow that paying more for quality should improve quality; however, the research evidence thus far is equivocal, particularly in terms of better health outcomes. One reason is that "financial incentives" encompass a range of payment types and sizes of reward. The design of financial incentives should take into account the desired change and the context of existing payment structures, as well as other strategies for improving quality; further, financial incentives should be fair in rewarding effort...
November 21, 2016: Medical Journal of Australia
https://www.readbyqxmd.com/read/27847490/neural-correlates-of-learning-from-induced-insight-a-case-for-reward-based-episodic-encoding
#6
Jasmin M Kizilirmak, Hannes Thuerich, Kristian Folta-Schoofs, Björn H Schott, Alan Richardson-Klavehn
Experiencing insight when solving problems can improve memory formation for both the problem and its solution. The underlying neural processes involved in this kind of learning are, however, thus far insufficiently understood. Here, we conceptualized insight as the sudden understanding of a novel relationship between known stimuli that fits into existing knowledge and is accompanied by a positive emotional response. Hence, insight is thought to comprise associative novelty, schema congruency, and intrinsic reward, all of which are separately known to enhance memory performance...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27847324/developmental-specification-of-forebrain-cholinergic-neurons
#7
REVIEW
Kathryn C Allaway, Robert Machold
Striatal cholinergic interneurons and basal forebrain cholinergic projection neurons, which together comprise the forebrain cholinergic system, regulate attention, memory, reward pathways, and motor activity through the neuromodulation of multiple brain circuits. The importance of these neurons in the etiology of neurocognitive disorders has been well documented, but our understanding of their specification during embryogenesis is still incomplete. All forebrain cholinergic projection neurons and interneurons appear to share a common developmental origin in the embryonic ventral telencephalon, a region that also gives rise to GABAergic projection neurons and interneurons...
November 12, 2016: Developmental Biology
https://www.readbyqxmd.com/read/27846733/ethnicity-work-related-stress-and-subjective-reports-of-health-by-migrant-workers-a-multi-dimensional-model
#8
Roberto Capasso, Maria Clelia Zurlo, Andrew P Smith
OBJECTIVES: This study integrates different aspects of ethnicity and work-related stress dimensions (based on the Demands-Resources-Individual-Effects model, DRIVE [Mark, G. M., and A. P. Smith. 2008. "Stress Models: A Review and Suggested New Direction." In Occupational Health Psychology, edited by J. Houdmont and S. Leka, 111-144. Nottingham: Nottingham University Press]) and aims to test a multi-dimensional model that combines individual differences, ethnicity dimensions, work characteristics, and perceived job satisfaction/stress as independent variables in the prediction of subjectives reports of health by workers differing in ethnicity...
November 16, 2016: Ethnicity & Health
https://www.readbyqxmd.com/read/27834117/reward-salience-and-attentional-networks-are-activated-by-religious-experience-in-devout-mormons
#9
Michael A Ferguson, Jared A Nielsen, Jace B King, Li Dai, Danielle M Giangrasso, Rachel Holman, Julie R Korenberg, Jeffrey S Anderson
High-level cognitive and emotional experience arises from brain activity, but the specific brain substrates for religious and spiritual euphoria remain unclear. We demonstrate using fMRI scans in 19 devout Mormons that a recognizable feeling central to their devotional practice was reproducibly associated with activation in nucleus accumbens, ventromedial prefrontal cortex, and frontal attentional regions. Nucleus accumbens activation preceded peak spiritual feelings by 1-3 seconds and was replicated in 4 separate tasks...
November 11, 2016: Social Neuroscience
https://www.readbyqxmd.com/read/27832596/cocaine-sensitization-increases-sub-threshold-activity-in-dopamine-neurons-from-the-ventral-tegmental-area
#10
Francisco Arencibia-Albite, Rafael Vazquez-Torres, Carlos A Jimenez-Rivera
The progressive escalation of psychomotor responses that results from repeated cocaine administration is termed sensitization. This phenomenon alters the intrinsic properties of dopamine (DA) neurons from the ventral tegmental area (VTA) leading to enhanced dopaminergic transmission in the mesocorticolimbic network. The mechanisms underlying this augmented excitation are nonetheless poorly understood. DA neurons display the hyperpolarization-activated non-selective cation current dubbed Ih. We recently demonstrated that Ih and membrane capacitance are substantially reduced in VTA DA cells from cocaine sensitized rats...
November 9, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27807881/payment-systems-and-incentives-in-dentistry
#11
Jostein Grytten
In this commentary, we discuss the advantages and disadvantages of the following incentive-based remuneration systems in dentistry: fee-for-service remuneration, per capita remuneration, a mixed payment system (a combination of fee-for-service remuneration and per capita remuneration) and pay-for-performance. The two latter schemes are fairly new in dentistry. Fee-for-service payments secure high quality, but lead to increased costs, probably due to supplier-induced demand. Per capita payments secure effectiveness, but may lead to under-treatment and patient selection...
November 3, 2016: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/27797848/invasive-thymoma-presenting-as-classic-superior-vena-cava-syndrome-a-case-of-venous-spread-metastasis
#12
Prasan Kumar Panda, Naveet Wig, Sanjeev Kumar, Sudheer Arava
The approach to an intrinsic cause of superior vena cava syndrome (SVCS) is usually difficult but rewarding. We report a case of a middle-aged man who presented with progressive oedema of the upper half of the body, dyspnoea, cough and weight loss for a 1-year duration. He was a non-smoker without prior hospitalisation. Chest radiography showed right-sided pleural effusion with an apparent normal superior mediastinum. Contrast-enhanced CT of the chest revealed a right atrial mass extending and completely obliterating to superior vena cava...
October 26, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27789262/reward-magnitude-tracking-by-neural-populations-in-ventral-striatum
#13
Ana M Fiallos, Sarah J Bricault, Lili X Cai, Hermoon A Worku, Matthew T Colonnese, Gil Westmeyer, Alan Jasanoff
Evaluation of the magnitudes of intrinsically rewarding stimuli is essential for assigning value and guiding behavior. By combining parametric manipulation of a primary reward, medial forebrain bundle (MFB) microstimulation, with functional magnetic imaging (fMRI) in rodents, we delineated a broad network of structures activated by behaviorally characterized levels of rewarding stimulation. Correlation of psychometric behavioral measurements with fMRI response magnitudes revealed regions whose activity corresponded closely to the subjective magnitude of rewards...
October 24, 2016: NeuroImage
https://www.readbyqxmd.com/read/27781362/spared-internal-but-impaired-external-reward-prediction-error-signals-in-major-depressive-disorder-during-reinforcement-learning
#14
Jasmina Bakic, Gilles Pourtois, Marieke Jepma, Romain Duprat, Rudi De Raedt, Chris Baeken
BACKGROUND: Major depressive disorder (MDD) creates debilitating effects on a wide range of cognitive functions, including reinforcement learning (RL). In this study, we sought to assess whether reward processing as such, or alternatively the complex interplay between motivation and reward might potentially account for the abnormal reward-based learning in MDD. METHODS: A total of 35 treatment resistant MDD patients and 44 age matched healthy controls (HCs) performed a standard probabilistic learning task...
October 26, 2016: Depression and Anxiety
https://www.readbyqxmd.com/read/27747888/the-role-of-intrinsic-and-extrinsic-rewards-in-committing-violence-during-combat-a-cross-sectional-study-with-former-combatants-in-the-dr-congo
#15
Roos Haer, Katharin Hermenau, Thomas Elbert, James K Moran, Tobias Hecker
It has been postulated that the violent behavior that characterizes armed conflict is reinforced by the possibility of receiving rewards. The present study examined the potential influence of two types of rewards in an ongoing setting of conflict: extrinsic and intrinsic rewards. Former combatants active in the Democratic Republic of the Congo (N = 198) were interviewed and questioned about the way they were recruited, the offenses they committed during combat, their level of perceived intrinsic rewards (i...
October 17, 2016: Aggressive Behavior
https://www.readbyqxmd.com/read/27739068/a-quantitative-review-of-overjustification-effects-in-persons-with-intellectual-and-developmental-disabilities
#16
Allison Levy, Iser G DeLeon, Catherine K Martinez, Nathalie Fernandez, Nicholas A Gage, Sigurdur Óli Sigurdsson, Michelle A Frank-Crawford
The overjustification hypothesis suggests that extrinsic rewards undermine intrinsic motivation. Extrinsic rewards are common in strengthening behavior in persons with intellectual and developmental disabilities; we examined overjustification effects in this context. A literature search yielded 65 data sets permitting comparison of responding during an initial no-reinforcement phase to a subsequent no-reinforcement phase, separated by a reinforcement phase. We used effect sizes to compare response levels in these two no-reinforcement phases...
October 14, 2016: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/27729874/dopamine-rebound-excitation-theory-putting-brakes-on-ptsd
#17
Jason C Lee, Lei Philip Wang, Joe Z Tsien
It is not uncommon for humans or animals to experience traumatic events in their lifetimes. However, the majority of individuals are resilient to long-term detrimental changes turning into anxiety and depression, such as post-traumatic stress disorder (PTSD). What underlying neural mechanism accounts for individual variability in stress resilience? Hyperactivity in fear circuits, such as the amygdalar system, is well-known to be the major pathophysiological basis for PTSD, much like a "stuck accelerator." Interestingly, increasing evidence demonstrates that dopamine (DA) - traditionally known for its role in motivation, reward prediction, and addiction - is also crucial in regulating fear learning and anxiety...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27713929/intrinsic-functional-connectivity-in-attention-deficit-hyperactivity-disorder-a-science-in-development
#18
F Xavier Castellanos, Yuta Aoki
Functional magnetic resonance imaging (fMRI) without an explicit task, i.e., resting state fMRI, of individuals with Attention-Deficit/Hyperactivity Disorder (ADHD) is growing rapidly. Early studies were unaware of the vulnerability of this method to even minor degrees of head motion, a major concern in the field. Recent efforts are implementing various strategies to address this source of artifact along with a growing set of analytical tools. Availability of the ADHD-200 Consortium dataset, a large-scale multi-site repository, is facilitating increasingly sophisticated approaches...
May 2016: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/27683883/persistence-of-reduced-neuromotor-noise-in-long-term-motor-skill-learning
#19
Meghan Elizabeth Huber, Nikita Kuznetsov, Dagmar Sternad
It is well documented that variability in motor performance decreases with practice. Yet, the neural and computational mechanisms that underlie this decline, particularly during long-term practice, are only little understood. Decreasing variability is frequently examined in terms of error corrections from one trial to the next. However, the ubiquitous noise from all levels of the sensorimotor system is also a significant contributor to overt variability. While neuromotor noise is typically assumed and modeled as immune to practice, the current study challenged this notion...
September 28, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27644419/intrinsic-monitoring-of-learning-success-facilitates-memory-encoding-via-the-activation-of-the-sn-vta-hippocampal-loop
#20
Pablo Ripollés, Josep Marco-Pallarés, Helena Alicart, Claus Tempelmann, Antoni Rodríguez-Fornells, Toemme Noesselt
Humans constantly learn in the absence of explicit rewards. However, the neurobiological mechanisms supporting this type of internally-guided learning (without explicit feedback) are still unclear. Here, participants who completed a task in which no external reward/feedback was provided, exhibited enhanced fMRI-signals within the dopaminergic midbrain, hippocampus, and ventral striatum (the SN/VTA-Hippocampal loop) when successfully grasping the meaning of new-words. Importantly, new-words that were better remembered showed increased activation and enhanced functional connectivity between the midbrain, hippocampus, and ventral striatum...
2016: ELife
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