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Keywords assessing new clinical criter...

assessing new clinical criteria for septic shock

https://read.qxmd.com/read/32025431/effect-of-beta-blockers-on-tachycardia-in-patients-with-pulmonary-embolism
#21
JOURNAL ARTICLE
Hafiz M Aslam, Hafiz S Naeem, Swati Prabhakar, Talha Awwal, Muhammad Khalid, Anand Kaji
Hypothesis Beta-blockers (BBs) lower the heart rate, which may mask the diagnosis of pulmonary embolism (PE) since one of the main clinical diagnoses of PE is tachycardia. The endpoint of our retrospective study is to determine if the pre-existing use of (BB) significantly affects the utility of these scoring criteria in diagnosing PE. Introduction Diagnosing PE is a challenge because of the non-specificity of its symptoms and signs. The initial step is to assess the patient's likelihood of having a PE. This involves using a scoring system to stratify patients into different levels of risk of having PE (for example, as 'low,' 'moderate,' or 'high' risk)...
December 30, 2019: Curēus
https://read.qxmd.com/read/31561400/acute-dizziness-with-potential-life-threatening-event-a-case-series-from-single-icu
#22
JOURNAL ARTICLE
Tong Dao-Ming, Zhou Ye-Ting
BACKGROUND: Whether the acute dizziness would be associated with potentially life-threatening event, which was previously unknown. METHODS: Between Jan 2014 and Dec 2016, We performed a retrospective survey to investigate the clinical data of patients with acute dizziness from an intensive care unit (ICU) in China. Inclusion criteria for all cases were presented with acute dizziness at onset, and then with a potentially life-threatening event. Baseline data and 30-days outcomes were collected...
2019: Journal of Vestibular Research: Equilibrium & Orientation
https://read.qxmd.com/read/31163469/-hospital-acquired-pneumonia-new-guidelines
#23
JOURNAL ARTICLE
Evelyn Kramme, Klaus Dalhoff
ETIOLOGY: The role of multidrug-resistant (MDR) pathogens in nosocomial infections is increasing. However national data in Germany do not show significant changes in the spectrum of pathogens in hospital-acquired pneumonia (HAP). The assessment of individual risk factors for MDR pathogens remains central for the selection of empiric antimicrobial therapy. DIAGNOSTICS: Thoracic ultrasound may be added as part of the diagnostic work-up and for the detection of complications...
June 2019: Deutsche Medizinische Wochenschrift
https://read.qxmd.com/read/31067656/current-issues-and-perspectives-in-patients-with-possible-sepsis-at-emergency-departments
#24
REVIEW
Ioannis Alexandros Charitos, Skender Topi, Francesca Castellaneta, Donato D'Agostino
In the area of Emergency Room (ER), many patients present criteria compatible with a SIRS, but only some of them have an associated infection. The new definition of sepsis by the European Society of Intensive Care Medicine and the Society of Critical Care Medicine (2016), revolutionizes precedent criteria, overcoming the concept of SIRS and clearly distinguishing the infection with the patient's physiological response from the symptoms of sepsis. Another fundamental change concerns the recognition method: The use of SOFA (Sequential-Sepsis Related-Organ Failure Assessment Score) as reference score for organ damage assessment...
May 7, 2019: Antibiotics
https://read.qxmd.com/read/29945330/pentraxin-3-predicts-short-and-mid-term-mortality-in-patients-with-sepsis-and-septic-shock-during-intensive-care-treatment
#25
JOURNAL ARTICLE
Sonja Hamed, Michael Behnes, Dominic Pauly, Dominic Lepiorz, Max Barre, Tobias Becher, Siegfried Lang, Ibrahim Akin, Martin Borggrefe, Thomas Bertsch, Ursula Hoffmann
BACKGROUND: The prognostic value of the acute phase protein Pentraxin 3 (PTX-3) is not well evaluated in patients with septic shock, which reveal an unacceptably high short- and long-term mortality. New Sepsis-3 definitions are not yet implemented in most biomarker studies. Therefore, this study assesses the prognostic value of PTX-3 for short- and mid-term mortality in patients with sepsis or septic shock, as defined by the latest definitions, treated at a medical intensive care unit (ICU)...
June 1, 2018: Clinical Laboratory
https://read.qxmd.com/read/29607156/clinical-outcome-comparison-of-patients-with-septic-shock-defined-by-the-new-sepsis-3-criteria-and-by-previous-criteria
#26
JOURNAL ARTICLE
Seung Mok Ryoo, Gu Hyun Kang, Tae Gun Shin, Sung Yeon Hwang, Kyuseok Kim, You Hwan Jo, Yoo Seok Park, Sung-Hyuk Choi, Young Hoon Yoon, Woon Yong Kwon, Gil Joon Suh, Tae Ho Lim, Kap Su Han, Han Sung Choi, Sung Phil Chung, Won Young Kim
BACKGROUND: We compared the clinical characteristics and outcomes between the new definition of sepsis-3 septic shock and the definition previously used from 1991 until recently. METHODS: We conducted an observational study using a prospective, multi-center registry of septic shock from October 2015 to February 2017. Registry data were collected by 10 emergency departments (EDs) in tertiary hospitals that are members of the Korean Shock Society. Data on septic shock patients who met the previous septic shock definition were collected...
February 2018: Journal of Thoracic Disease
https://read.qxmd.com/read/29478200/ph-after-the-first-session-of-direct-hemoperfusion-with-polymyxin-b-immobilized-fibers-predicts-mortality-in-patients-with-sepsis-and-septic-shock
#27
JOURNAL ARTICLE
Aiko Okubo, Ayumu Nakashima, Shigehiro Doi, Toshinori Ueno, Kensuke Sasaki, Takashi Esaki, Takao Masaki
BACKGROUND: The definition of sepsis was updated to sepsis-3 in February 2016. Currently, direct hemoperfusion therapy using the polymyxin B-immobilized fiber cartridge (PMX-DHP) is widely performed to treat sepsis and septic shock. However, the prognostic factors of PMX-DHPs in patients with sepsis using the new definition are unclear. We retrospectively assessed prognostic factors in patients who had received PMX-DHP therapy for sepsis and septic shock. METHODS: We included 71 patients with severe infection who underwent PMX-DHP treatment from January 2006 to August 2015 in this study...
October 2018: Clinical and Experimental Nephrology
https://read.qxmd.com/read/29475445/prognosis-of-patients-excluded-by-the-definition-of-septic-shock-based-on-their-lactate-levels-after-initial-fluid-resuscitation-a-prospective-multi-center-observational-study
#28
MULTICENTER STUDY
Byuk Sung Ko, Kyuseok Kim, Sung-Hyuk Choi, Gu Hyun Kang, Tae Gun Shin, You Hwan Jo, Seung Mok Ryoo, Jin Ho Beom, Woon Yong Kwon, Kap Su Han, Han Sung Choi, Sung Phil Chung, Gil Joon Suh, Tae Ho Lim, Won Young Kim
BACKGROUND: Septic shock can be defined both by the presence of hyperlactatemia and need of vasopressors. Lactate levels should be measured after volume resuscitation (as per the Sepsis-3 definition). However, currently, no studies have evaluated patients who have been excluded by the new criteria for septic shock. The aim of this study was to determine the clinical characteristics and prognosis of these patients, based on their lactate levels after initial fluid resuscitation. METHODS: This observational study was performed using a prospective, multi-center registry of septic shock, with the participation of 10 hospitals in the Korean Shock Society, between October 2015 and February 2017...
February 24, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/29370285/severe-community-acquired-pneumonia-characteristics-and-prognostic-factors-in-ventilated-and-non-ventilated-patients
#29
COMPARATIVE STUDY
Miquel Ferrer, Chiara Travierso, Catia Cilloniz, Albert Gabarrus, Otavio T Ranzani, Eva Polverino, Adamantia Liapikou, Francesco Blasi, Antoni Torres
BACKGROUND: Patients with severe community-acquired pneumonia (SCAP) and life-threatening acute respiratory failure may require invasive mechanical ventilation (IMV). Since use of IMV is often associated with significant morbidity and mortality, we assessed whether patients invasively ventilated would represent a target population for interventions aimed at reducing mortality of SCAP. METHODS: We prospectively recruited consecutive patients with SCAP for 12 years...
2018: PloS One
https://read.qxmd.com/read/29181605/symptomatic-heart-failure-after-transjugular-intrahepatic-portosystemic-shunt-placement-incidence-outcomes-and-predictors
#30
JOURNAL ARTICLE
Kunjam Modha, Baljendra Kapoor, Rocio Lopez, Mark J Sands, William Carey
PURPOSE: To assess the incidence of symptomatic heart failure (SHF) occurring after transjugular intrahepatic portosystemic shunt (TIPS) placement, identify potential predictors of SHF, and evaluate clinical presentation and outcomes in cases of post-TIPS SHF. MATERIALS AND METHODS: A prospectively maintained TIPS database was used to identify patients who underwent new TIPS placements at a large urban tertiary care center between 1995 and 2014. SHF was defined as otherwise unexplained new-onset dyspnea, hypoxemia, radiologic pulmonary edema, an increased need for diuretics, or need for intubation within 7 days after TIPS placement...
April 2018: Cardiovascular and Interventional Radiology
https://read.qxmd.com/read/28771567/muscle-oxygenation-as-an-indicator-of-shock-severity-in-patients-with-suspected-severe-sepsis-or-septic-shock
#31
JOURNAL ARTICLE
Kenneth A Schenkman, David J Carlbom, Eileen M Bulger, Wayne A Ciesielski, Dana M Fisk, Kellie L Sheehan, Karin M Asplund, Jeremy M Shaver, Lorilee S L Arakaki
PURPOSE: The aim of this pilot study was to evaluate the potential of a new noninvasive optical measurement of muscle oxygenation (MOx) to identify shock severity in patients with suspected sepsis. METHODS: We enrolled 51 adult patients in the emergency department (ED) who presented with possible sepsis using traditional Systematic Inflammatory Response Syndrome criteria or who triggered a "Code Sepsis." Noninvasive MOx measurements were made from the first dorsal interosseous muscles of the hand once potential sepsis/septic shock was identified, as soon as possible after admission to the ED...
2017: PloS One
https://read.qxmd.com/read/28687209/new-sepsis-and-septic-shock-definitions-clinical-implications-and-controversies
#32
REVIEW
Chanu Rhee, Michael Klompas
New sepsis definitions shift emphasis from the systemic inflammatory response syndrome to organ dysfunction, quantified using the Sequential Organ Failure Assessment (SOFA) score. The new definitions also propose Quick SOFA criteria to rapidly identify potentially infected patients at risk for poor outcomes. The diagnosis of septic shock requires vasopressor dependence and increased lactate levels. Strengths of these definitions include their simplicity and clear association with adverse outcomes. However, their utility in identifying patients with serious infections before frank sepsis ensues remains to be seen...
September 2017: Infectious Disease Clinics of North America
https://read.qxmd.com/read/28558733/towards-a-consensus-definition-of-maternal-sepsis-results-of-a-systematic-review-and-expert-consultation
#33
REVIEW
Mercedes Bonet, Vicky Nogueira Pileggi, Marcus J Rijken, Arri Coomarasamy, David Lissauer, João Paulo Souza, Ahmet Metin Gülmezoglu
BACKGROUND: There is a need for a clear and actionable definition of maternal sepsis, in order to better assess the burden of this condition, trigger timely and effective treatment and allow comparisons across facilities and countries. The objective of this study was to review maternal sepsis definitions and identification criteria and to report on the results of an expert consultation to develop a new international definition of maternal sepsis. METHODS: All original and review articles and WHO documents, as well as clinical guidelines providing definitions and/or identification criteria of maternal sepsis were included...
May 30, 2017: Reproductive Health
https://read.qxmd.com/read/28342442/comparison-of-qsofa-and-sirs-for-predicting-adverse-outcomes-of-patients-with-suspicion-of-sepsis-outside-the-intensive-care-unit
#34
JOURNAL ARTICLE
Eli J Finkelsztein, Daniel S Jones, Kevin C Ma, Maria A Pabón, Tatiana Delgado, Kiichi Nakahira, John E Arbo, David A Berlin, Edward J Schenck, Augustine M K Choi, Ilias I Siempos
BACKGROUND: The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Task Force recently introduced a new clinical score termed quick Sequential (Sepsis-related) Organ Failure Assessment (qSOFA) for identification of patients at risk of sepsis outside the intensive care unit (ICU). We attempted to compare the discriminatory capacity of the qSOFA versus the Systemic Inflammatory Response Syndrome (SIRS) score for predicting mortality, ICU-free days, and organ dysfunction-free days in patients with suspicion of infection outside the ICU...
March 26, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/27637985/ibrutinib-for-patients-with-relapsed-or-refractory-chronic-lymphocytic-leukaemia-with-17p-deletion-resonate-17-a-phase-2-open-label-multicentre-study
#35
MULTICENTER STUDY
Susan O'Brien, Jeffrey A Jones, Steven E Coutre, Anthony R Mato, Peter Hillmen, Constantine Tam, Anders Österborg, Tanya Siddiqi, Michael J Thirman, Richard R Furman, Osman Ilhan, Michael J Keating, Timothy G Call, Jennifer R Brown, Michelle Stevens-Brogan, Yunfeng Li, Fong Clow, Danelle F James, Alvina D Chu, Michael Hallek, Stephan Stilgenbauer
BACKGROUND: The TP53 gene, encoding tumour suppressor protein p53, is located on the short arm of chromosome 17 (17p). Patients with 17p deletion (del17p) chronic lymphocytic leukaemia have poor responses and survival after chemoimmunotherapy. We assessed the activity and safety of ibrutinib, an oral covalent inhibitor of Bruton's tyrosine kinase, in relapsed or refractory patients with del17p chronic lymphocytic leukaemia or small lymphocytic lymphoma. METHODS: We did a multicentre, international, open-label, single-arm study at 40 sites in the USA, Canada, Europe, Australia, and New Zealand...
October 2016: Lancet Oncology
https://read.qxmd.com/read/26903338/the-third-international-consensus-definitions-for-sepsis-and-septic-shock-sepsis-3
#36
JOURNAL ARTICLE
Mervyn Singer, Clifford S Deutschman, Christopher Warren Seymour, Manu Shankar-Hari, Djillali Annane, Michael Bauer, Rinaldo Bellomo, Gordon R Bernard, Jean-Daniel Chiche, Craig M Coopersmith, Richard S Hotchkiss, Mitchell M Levy, John C Marshall, Greg S Martin, Steven M Opal, Gordon D Rubenfeld, Tom van der Poll, Jean-Louis Vincent, Derek C Angus
IMPORTANCE: Definitions of sepsis and septic shock were last revised in 2001. Considerable advances have since been made into the pathobiology (changes in organ function, morphology, cell biology, biochemistry, immunology, and circulation), management, and epidemiology of sepsis, suggesting the need for reexamination. OBJECTIVE: To evaluate and, as needed, update definitions for sepsis and septic shock. PROCESS: A task force (n = 19) with expertise in sepsis pathobiology, clinical trials, and epidemiology was convened by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine...
February 23, 2016: JAMA
https://read.qxmd.com/read/26903336/developing-a-new-definition-and-assessing-new-clinical-criteria-for-septic-shock-for-the-third-international-consensus-definitions-for-sepsis-and-septic-shock-sepsis-3
#37
REVIEW
Manu Shankar-Hari, Gary S Phillips, Mitchell L Levy, Christopher W Seymour, Vincent X Liu, Clifford S Deutschman, Derek C Angus, Gordon D Rubenfeld, Mervyn Singer
IMPORTANCE: Septic shock currently refers to a state of acute circulatory failure associated with infection. Emerging biological insights and reported variation in epidemiology challenge the validity of this definition. OBJECTIVE: To develop a new definition and clinical criteria for identifying septic shock in adults. DESIGN, SETTING, AND PARTICIPANTS: The Society of Critical Care Medicine and the European Society of Intensive Care Medicine convened a task force (19 participants) to revise current sepsis/septic shock definitions...
February 23, 2016: JAMA
https://read.qxmd.com/read/26903335/assessment-of-clinical-criteria-for-sepsis-for-the-third-international-consensus-definitions-for-sepsis-and-septic-shock-sepsis-3
#38
JOURNAL ARTICLE
Christopher W Seymour, Vincent X Liu, Theodore J Iwashyna, Frank M Brunkhorst, Thomas D Rea, André Scherag, Gordon Rubenfeld, Jeremy M Kahn, Manu Shankar-Hari, Mervyn Singer, Clifford S Deutschman, Gabriel J Escobar, Derek C Angus
IMPORTANCE: The Third International Consensus Definitions Task Force defined sepsis as "life-threatening organ dysfunction due to a dysregulated host response to infection." The performance of clinical criteria for this sepsis definition is unknown. OBJECTIVE: To evaluate the validity of clinical criteria to identify patients with suspected infection who are at risk of sepsis. DESIGN, SETTINGS, AND POPULATION: Among 1.3 million electronic health record encounters from January 1, 2010, to December 31, 2012, at 12 hospitals in southwestern Pennsylvania, we identified those with suspected infection in whom to compare criteria...
February 23, 2016: JAMA
https://read.qxmd.com/read/26822963/shockomics-multiscale-approach-to-the-identification-of-molecular-biomarkers-in-acute-heart-failure-induced-by-shock
#39
MULTICENTER STUDY
Federico Aletti, Costanza Conti, Manuela Ferrario, Vicent Ribas, Bernardo Bollen Pinto, Antoine Herpain, Emiel Post, Eduardo Romay Medina, Cristina Barlassina, Eliandre de Oliveira, Roberta Pastorelli, Gabriella Tedeschi, Giuseppe Ristagno, Fabio S Taccone, Geert W Schmid-Schönbein, Ricard Ferrer, Daniel De Backer, Karim Bendjelid, Giuseppe Baselli
BACKGROUND: The ShockOmics study (ClinicalTrials.gov identifier NCT02141607) is a multicenter prospective observational trial aimed at identifying new biomarkers of acute heart failure in circulatory shock, by means of a multiscale analysis of blood samples and hemodynamic data from subjects with circulatory shock. METHODS AND DESIGN: Ninety septic shock and cardiogenic shock patients will be recruited in three intensive care units (ICU) (Hôpital Erasme, Université Libre de Bruxelles, Belgium; Hospital Universitari Mutua Terrassa, Spain; Hôpitaux Universitaires de Genève, Switzerland)...
January 28, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://read.qxmd.com/read/26623644/clinical-performance-of-a-new-soluble-cd14-subtype-immunochromatographic-test-for-whole-blood-compared-with-chemiluminescent-enzyme-immunoassay-use-of-quantitative-soluble-cd14-subtype-immunochromatographic-tests-for-the-diagnosis-of-sepsis
#40
JOURNAL ARTICLE
Masayuki Sato, Gaku Takahashi, Shigehiro Shibata, Makoto Onodera, Yasushi Suzuki, Yoshihiro Inoue, Shigeatsu Endo
We previously reported that a soluble CD14-subtype (sCD14-ST) immunochromatographic test (ICT) for plasma is more convenient than chemiluminescent enzyme immunoassay (CLEIA), but plasma separation makes bedside measurements difficult. We developed a new sCD14-ST ICT for whole blood and investigated whether quantitative determinations of sCD14-ST by ICT were useful for diagnosing sepsis and severe sepsis/septic shock. We studied 20 patients who fulfilled two or more systemic inflammatory response syndrome (SIRS) criteria and 32 patients who had been diagnosed with sepsis or severe sepsis/septic shock...
2015: PloS One
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