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Vaccination in COPD

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https://www.readbyqxmd.com/read/28729620/self-management-behaviour-and-support-among-primary-care-copd-patients-cross-sectional-analysis-of-data-from-the-birmingham-chronic-obstructive-pulmonary-disease-cohort
#1
Ainee Khan, Andrew P Dickens, Peymane Adab, Rachel E Jordan
Self-management support for chronic obstructive pulmonary disease (COPD) patients is recommended by UK national guidelines, but extent of implementation is unknown. We aimed to describe self-management behaviour and support among COPD patients and explore behaviour associated with having a self-management plan. We undertook cross-sectional analysis of self-reported data from diagnosed COPD patients in the Birmingham COPD Cohort study. Questionnaire items relevant to self-management behaviour, knowledge of COPD, receipt of self-management plans and advice from healthcare professionals were examined...
July 20, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28719225/association-between-social-support-and-self-care-behaviors-in-adults-with-chronic-obstructive-pulmonary-disease
#2
Zijing Chen, Vincent S Fan, Basia Belza, Kenneth Pike, Huong Q Nguyen
RATIONALE: Higher social support is associated with a better quality of life and functioning in adults with chronic obstructive pulmonary disease (COPD). OBJECTIVES: To determine the association between structural and functional social support and self-care behaviors in adults with COPD. METHODS: This was a longitudinal study using data from the CASCADE (COPD Activity: Serotonin Transporter, Cytokines, and Depression) study which was focused on depression and functioning in COPD...
July 18, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28694340/colonisation-of-irish-patients-with-chronic-obstructive-pulmonary-disease-by-streptococcus-pneumoniae-and-analysis-of-the-pneumococcal-vaccine-coverage-a-non-interventional-observational-prospective-cohort-study
#3
Hannah McCarthy, Mandy Jackson, Mary Corcoran, Martha McElligott, Elaine MacHale, Imran Sulaiman, Breda Cushen, Richard W Costello, Hilary Humpreys
OBJECTIVES: To characterise the pattern of colonisation and serotypes of Streptococcus pneumoniae among patients with chronic obstructive pulmonary disease (COPD) who currently receive the 23-valent pneumococcal polysaccharide vaccine (PPV-23) according to vaccination status, use of antibiotics and steroids. To investigate the prevalence of PPV-23 and 13-valent pneumococcal conjugate vaccine (PCV-13) serotypes within the study cohort. DESIGN: A non-interventional, observational, prospective cohort study with a 12 -month follow-up period inclusive of quarterly study visits...
July 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28667071/pulmonary-immunity-to-viruses
#4
REVIEW
S Rameeza Allie, Troy D Randall
Mucosal surfaces, such as the respiratory epithelium, are directly exposed to the external environment and therefore, are highly susceptible to viral infection. As a result, the respiratory tract has evolved a variety of innate and adaptive immune defenses in order to prevent viral infection or promote the rapid destruction of infected cells and facilitate the clearance of the infecting virus. Successful adaptive immune responses often lead to a functional state of immune memory, in which memory lymphocytes and circulating antibodies entirely prevent or lessen the severity of subsequent infections with the same virus...
July 15, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28659326/a-cation-binding-surface-protein-as-a-vaccine-antigen-to-prevent-moraxella-catarrhalis-otitis-media-and-infections-in-chronic-obstructive-pulmonary-disease
#5
Timothy F Murphy, Aimee L Brauer, Antoinette Johnson, Gregory E Wilding, Mary Koszelak-Rosenblum, Michael G Malkowski
Moraxella catarrhalis is an exclusively human respiratory tract pathogen that is a common cause of otitis media in children and respiratory tract infections in adults with chronic obstructive pulmonary disease. A vaccine to prevent these infections would have a major impact in reducing the substantial global morbidity and mortality in these populations. Through a genome mining approach, we identified AfeA, an ∼32 kDa substrate binding protein of an ABC transport system as an excellent candidate vaccine antigen...
June 28, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28626902/haemophilus-influenzae-oral-vaccination-for-preventing-acute-exacerbations-of-chronic-bronchitis-and-chronic-obstructive-pulmonary-disease
#6
REVIEW
Edward Teo, Kathleen Lockhart, Sai Navya Purchuri, Jennifer Pushparajah, Allan W Cripps, Mieke L van Driel
BACKGROUND: Chronic bronchitis and chronic obstructive pulmonary disease (COPD) are serious conditions in which patients are predisposed to viral and bacterial infections resulting in potentially fatal acute exacerbations. Chronic obstructive pulmonary disease is defined as a lung disease characterised by obstruction to lung airflow that interferes with normal breathing. Antibiotic therapy has not been particularly useful in eradicating bacteria such as non-typeable Haemophilus influenzae (NTHi) because they are naturally occurring flora of the upper respiratory tract in many people...
June 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28585796/-impact-of-13-valent-pneumococal-conjugate-polysaccharide-vaccination-in-exacerbations-rate-of-copd-patients-with-moderate-to-severe-obstruction
#7
J M Figueira-Gonçalves, N Bethencourt-Martín, L I Pérez-Méndez, D Díaz-Pérez, C Guzmán-Sáenz, P Viña-Manrique, A J Pedrero-García
OBJECTIVE: One of the major microorganisms described as the cause of exacerbations of chronic obstructive pulmonary disease (COPD) is Streptococcus pneumoniae. The aim of this study is to evaluate the impact of 13-valent pneumococcal conjugate polysaccharide vaccine (PCV13) in COPD patients with regard to the development of exacerbations and the possible differential effect according to the patient's phenotype. METHODS: Prospective observational study of patients with COPD and FEV1 ≤ 65% and 18-month follow-up...
June 6, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/28578989/-changing-patterns-of-medication-prescription-for-copd-patients-in-france-impact-of-long-acting-muscarinic-antagonists-availability
#8
G Jébrak, P-R Burgel, D Caillaud, G Deslée, G Brinchault, P Chanez, I Court-Fortune, R Escamilla, P Nesme-Meyer, C Pinet, T Perez, J-L Paillasseur, N Roche
INTRODUCTION: We studied the pattern changes over time of medication prescriptions for COPD and their conformity with French and international recommendations using data from patients in the prospective French cohort "Initiatives BPCO". METHOD: Eight hundred and forty-six patients have been included during a first period from August, 2001 till May 2006 (n=425) and a second period from June, 2006 till June, 2012 (n=421). The pivotal date was based on the tiotropium availability in France...
May 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28539074/nontypeable-haemophilus-influenzae-and-chronic-obstructive-pulmonary-disease-a-review-for-clinicians
#9
Krishna Bajee Sriram, Amanda J Cox, Robert L Clancy, Mary P E Slack, Allan W Cripps
Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of morbidity and mortality worldwide. In the lower airways of COPD patients, bacterial infection is a common phenomenon and Haemophilus influenzae is the most commonly identified bacteria. Haemophilus influenzae is divided into typeable and nontypeable (NTHi) strains based on the presence or absence of a polysaccharide capsule. While NTHi is a common commensal in the human nasopharynx, it is associated with considerable inflammation when it is present in the lower airways of COPD patients, resulting in morbidity due to worsening symptoms and increased frequency of COPD exacerbations...
May 25, 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28505636/review-in-copd-injectable-polyvalent-pneumococcal-vaccines-reduce-risk-for-community-acquired-pneumonia
#10
Matthew B Stanbrook
No abstract text is available yet for this article.
May 16, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28502165/grape-seed-proanthocyanidin-inhibits-mucin-synthesis-and-viral-replication-by-suppression-of-ap-1-and-nf-%C3%AE%C2%BAb-via-p38-mapks-jnk-signaling-pathways-in-respiratory-syncytial-virus-infected-a549-cells
#11
Jin-Woo Lee, Young Il Kim, Chang-Nim Im, Sung Wan Kim, Su Jin Kim, Seoyeon Min, Yong Hoon Joo, Sung-Vin Yim, Namhyun Chung
Airway epithelial cells are often infected by respiratory syncytial virus (RSV), one of the most common causes of asthma, bronchiolitis, chronic obstructive pulmonary disease, and pneumonia. During the infection process, excessive mucins instigate airway inflammation. However, the mechanism underlying RSV-induced airway hyper-responsiveness and inflammation is poorly understood. Furthermore, no reliable vaccines or drugs for antiviral therapy are available. In this study, the effect of the natural compound grape seed proanthocyanidin (GSP) on RSV-infected human airway epithelial cells A549 was evaluated...
June 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28468650/seasonal-influenza-vaccination-in-patients-with-copd-a-systematic-literature-review
#12
Rafik Bekkat-Berkani, Tom Wilkinson, Philippe Buchy, Gael Dos Santos, Dimitris Stefanidis, Jeanne-Marie Devaster, Nadia Meyer
BACKGROUND: Influenza is a frequent cause of exacerbations of chronic obstructive pulmonary disease (COPD). Exacerbations are associated with worsening of the airflow obstruction, hospitalisation, reduced quality of life, disease progression, death, and ultimately, substantial healthcare-related costs. Despite longstanding recommendations to vaccinate vulnerable high-risk groups against seasonal influenza, including patients with COPD, vaccination rates remain sub-optimal in this population...
May 3, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28462763/economic-burden-of-diagnosed-pertussis-among-individuals-with-asthma-or-chronic-obstructive-pulmonary-disease-in-the-usa-an-analysis-of-administrative-claims
#13
P O Buck, J L Meyers, L-D Gordon, R Parikh, S K Kurosky, K L Davis
Individuals with chronic respiratory conditions may be at increased risk for pertussis. We conducted a retrospective administrative claims analysis to examine the incidence and economic burden of diagnosed pertussis among adolescents and adults in the USA with chronic obstructive pulmonary disease (COPD) or asthma. Patients aged ⩾11 years with diagnosed pertussis and pre-existing COPD (n = 343) or asthma (n = 1041) were matched 1:1 to patients with diagnosed pertussis but without COPD or asthma. Differences in all-cause costs ('excess' costs) during the 45-day and 3-month and 6-month periods before and after the pertussis index date were calculated; adjusted excess costs were estimated via multivariate regressions...
July 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28443565/influenza-and-pneumonia-vaccination-rates-and-factors-affecting-vaccination-among-patients-with-chronic-obstructive-pulmonary-disease
#14
Ülkü Aka Aktürk, Aslı Görek Dilektaşlı, Aysun Şengül, Banu Musaffa Salepçi, Nuray Oktay, Mustafa Düger, Hale Arık Taşyıkan, Nagihan Durmuş Koçak
BACKGROUND: Influenza and pneumococcal vaccinations are recommended in chronic obstructive pulmonary disease patients to decrease associated risks at all stages. Although the prevalence of chronic obstructive pulmonary disease is high in our country, as previously reported, vaccination rates are low. AIMS: To assess the vaccination rates of chronic obstructive pulmonary disease patients and factors that may affect these. STUDY DESIGN: Multi-centre cross-sectional study...
May 5, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28378726/-impact-of-vaccination-on-the-course-of-bronchial-and-systemic-inflammation-in-patients-with-copd-and-chd
#15
G L Ignatova, V N Antonov
AIM: To investigate the effect of 13-valent pneumococcal conjugate vaccine (PCV-13) on the clinical and functional manifestations of systemic inflammation in patients with chronic obstructive pulmonary disease (COPD) and coronary heart disease (CHD). SUBJECTS AND METHODS: The protocol included 36 patients with COPD and 36 patients with COPD concurrent with CHD. The number of COPD exacerbations, hospital admissions, pneumonia cases, degree of dyspnea, and functional indicators were analyzed...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28326177/characterization-of-secondary-care-for-copd-in-sweden
#16
Josefin Sundh, Christer Janson, Gunnar Johansson, Anders Lindén, Claes-Göran Löfdahl, Thomas Sandström, Kjell Larsson
Introduction: Only a selected proportion of chronic obstructive pulmonary disease (COPD) patients are managed in secondary care. The aim of this study was to characterize disease severity, treatment and structure of secondary care for COPD in Sweden. Methods: Information was collected from 29 of 33 existing secondary care units of respiratory medicine in Sweden, using both individual data from 373 consecutively enrolled COPD patients with Global initiative on Obstructive Lung Disease (GOLD) stage III-IV and a structural questionnaire about available resources at the units...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28298389/screening-for-copd-the-gap-between-logic-and-evidence
#17
REVIEW
Alan Kaplan, Mike Thomas
Chronic obstructive pulmonary disease (COPD) is a common disease leading to further morbidity and significant mortality. The first step for any condition is to make the appropriate diagnosis, and spirometry barriers abound in practice around the world. It is tempting to undertake mass screening on all smokers to detect COPD. While this would pick up cases of COPD, results of studies of its effect on COPD end-points such as exacerbations, hospitalisations and mortality are disappointing. As such, aggressive case finding of COPD by screening for symptoms that patients may not themselves perceive is very important in primary care, with subsequent spirometry defining the diagnosis...
January 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28283854/management-of-the-asthma-copd-overlap-syndrome-acos-a-review-of-the-evidence
#18
REVIEW
Kristin L Hines, R Stokes Peebles
PURPOSE OF REVIEW: Examine the definition of the asthma-COPD overlap syndrome (ACOS) and current treatment strategies. RECENT FINDINGS: Patients with the ACOS have a lower quality of life and suffer from more complications than those affected by either disease alone. Diagnosis of ACOS is difficult because of the clinical similarities between the two diseases and the various phenotypes that comprise the syndrome. Defining treatment strategies for ACOS has been challenging because many clinical trials for asthma therapy have purposefully excluded patients with features of COPD, and COPD clinical trials have not included patients who might have an asthmatic component to their disease...
March 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28245825/predictors-of-correct-technique-in-patients-using-pressurized-metered-dose-inhalers
#19
Kyra Bartolo, Martin Balzan, Emma Louise Schembri, Rachelle Asciak, Darlene Mercieca Balbi, Michael Pace Bardon, Stephen Montefort
BACKGROUND: Corret inhaler technique is recommended by guidelines for optimum asthma care. The objective of the study is to determine real life predictors of correct pressurized metered dose inhaler (pMDI) technique in Asthma and COPD patients. METHODS: Two hundred eight adult patients aged 18+ from respiratory outpatients (69.2%) and the community on regular pMDI for a diagnosis of Asthma (78.9%) or COPD, were recruited. A questionnaire containing 31 possible predictors was administered and pMDI technique with or without spacer was observed by trained researchers on 12 point steps, of which 4 were considered critical...
February 28, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28245616/the-impacts-of-cellular-senescence-in-elderly-pneumonia-and-in-age-related-lung-diseases-that-increase-the-risk-of-respiratory-infections
#20
REVIEW
Shigehisa Yanagi, Hironobu Tsubouchi, Ayako Miura, Ayako Matsuo, Nobuhiro Matsumoto, Masamitsu Nakazato
Pneumonia generates considerable negative impacts on the elderly. Despite the widespread uses of vaccines and appropriate antibiotics, the morbidity and mortality of elderly pneumonia are significantly higher compared to the counterparts of young populations. The definitive mechanisms of high vulnerability in the elderly against pathogen threats are unclear. Age-associated, chronic low-grade inflammation augments the susceptibility and severity of pneumonia in the elderly. Cellular senescence, one of the hallmarks of aging, has its own characteristics, cell growth arrest and senescence-associated secretory phenotype (SASP)...
February 25, 2017: International Journal of Molecular Sciences
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