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Vaccination in COPD

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https://www.readbyqxmd.com/read/29555745/-haemophilus-influenzae-genome-evolution-during-persistence-in-the-human-airways-in-chronic-obstructive-pulmonary-disease
#1
Melinda M Pettigrew, Christian P Ahearn, Janneane F Gent, Yong Kong, Mary C Gallo, James B Munro, Adonis D'Mello, Sanjay Sethi, Hervé Tettelin, Timothy F Murphy
Nontypeable Haemophilus influenzae (NTHi) exclusively colonize and infect humans and are critical to the pathogenesis of chronic obstructive pulmonary disease (COPD). In vitro and animal models do not accurately capture the complex environments encountered by NTHi during human infection. We conducted whole-genome sequencing of 269 longitudinally collected cleared and persistent NTHi from a 15-y prospective study of adults with COPD. Genome sequences were used to elucidate the phylogeny of NTHi isolates, identify genomic changes that occur with persistence in the human airways, and evaluate the effect of selective pressure on 12 candidate vaccine antigens...
March 19, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29540496/exacerbations-of-copd
#2
Christian Viniol, Claus F Vogelmeier
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. While COPD is a mainly chronic disease, a substantial number of patients suffer from exacerbations. Severe exacerbations are related to a significantly worse survival outcome. This review summarises the current knowledge on the different aspects of COPD exacerbations. The impact of risk factors and triggers such as smoking, severe airflow limitation, bronchiectasis, bacterial and viral infections and comorbidities is discussed...
March 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29531747/patterns-and-management-of-chronic-obstructive-pulmonary-disease-in-urban-and-rural-china-a-community-based-survey-of-25-000-adults-across-10-regions
#3
Om P Kurmi, Kourtney J Davis, Kin Bong Hubert Lam, Yu Guo, Julien Vaucher, Derrick Bennett, Jenny Wang, Zheng Bian, Huaidong Du, Liming Li, Robert Clarke, Zhengming Chen
Introduction: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, with COPD deaths in China accounting for one-third of all such deaths. However, there is limited available evidence on the management of COPD in China. Methods: A random sample of 25 011 participants in the China Kadoorie Biobank, aged 38-87 years, from 10 regions in China was surveyed in 2013-2014. Data were collected using interviewer-administered questionnaires on the diagnosis ('doctor-diagnosed' or 'symptoms-based') and management of COPD (including use of medication and other healthcare resources), awareness of diagnosis and severity of symptoms in COPD cases...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29415569/the-adhesins-of-non-typeable-haemophilus-influenzae
#4
Karen L Osman, Johanna M Jefferies, Christopher H Woelk, David W Cleary, Stuart C Clarke
Non-typeable Haemophilus influenzae (NTHi) is an opportunistic pathogen of the respiratory tract and the greatest contributor to invasive Haemophilus disease. Additionally, in children, NTHi is responsible for the majority of otitis media (OM) which can lead to chronic infection and hearing loss. In adults, NTHi infection in the lungs is responsible for the onset of acute exacerbations in chronic obstructive pulmonary disease (COPD). Unfortunately, there is currently no vaccine available to protect against NTHi infections...
February 8, 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29229095/primary-immune-deficiency-diseases-as-unrecognized-causes-of-chronic-respiratory-disease
#5
REVIEW
Melvin Berger, Bob Geng, D William Cameron, Ladonna M Murphy, Edward S Schulman
BACKGROUND: More than half of all primary immune deficiency diseases (PIDD) affect antibody production and are well known as causes of recurrent sinusitis and lung infections. Chronic and recurrent infections of the upper and/or lower airways can contribute to inflammatory and obstructive processes in the lower airways which are initially reversible and considered "asthma", but can eventually cause irreversible remodeling and chronic obstructive pulmonary disease (COPD). Conversely, several lines of evidence suggest that many patients who present with a diagnosis of asthma have an increased incidence of infection, suggesting underlying host-defense defects...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29203544/mapping-protective-regions-on-a-three-dimensional-model-of-the-moraxella-catarrhalis-vaccine-antigen-oligopeptide-permease-a
#6
Antonia C Perez, Antoinette Johnson, Ziqiang Chen, Gregory E Wilding, Michael G Malkowski, Timothy F Murphy
A vaccine against Moraxella catarrhalis would reduce tremendous morbidity, mortality, and financial burden by preventing otitis media in children and exacerbations of chronic obstructive pulmonary disease (COPD) in adults. Oligopeptide permease A (OppA) is a candidate vaccine antigen that is (i) a nutritional virulence factor expressed on the bacterial cell surface during infection, (ii) widely conserved among strains, (iii) highly immunogenic, and (iv) a protective antigen based on its capacity to induce protective responses in immunized animals...
March 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29129177/copd-x-australian-and-new-zealand-guidelines-for-the-diagnosis-and-management-of-chronic-obstructive-pulmonary-disease-2017-update
#7
Ian A Yang, Juliet L Brown, Johnson George, Sue Jenkins, Christine F McDonald, Vanessa M McDonald, Kirsten Phillips, Brian J Smith, Nicholas A Zwar, Eli Dabscheck
Chronic obstructive pulmonary disease (COPD) is characterised by persistent respiratory symptoms and chronic airflow limitation, and is associated with exacerbations and comorbidities. Advances in the management of COPD are updated quarterly in the national COPD guidelines, the COPD-X plan, published by Lung Foundation Australia in conjunction with the Thoracic Society of Australia and New Zealand and available at http://copdx.org.au. Main recommendations: Spirometry detects persistent airflow limitation (post-bronchodilator FEV1/FVC < 0...
November 20, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/29062228/impact-and-prevention-of-severe-exacerbations-of-copd-a-review-of-the-evidence
#8
REVIEW
David Mg Halpin, Marc Miravitlles, Norbert Metzdorf, Bartolomé Celli
Severe exacerbations of COPD, ie, those leading to hospitalization, have profound clinical implications for patients and significant economic consequences for society. The prevalence and burden of severe COPD exacerbations remain high, despite recognition of the importance of exacerbation prevention and the availability of new treatment options. Severe COPD exacerbations are associated with high mortality, have negative impact on quality of life, are linked to cardiovascular complications, and are a significant burden on the health-care system...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29020801/factors-influencing-influenza-vaccination-among-patients-with-chronic-obstructive-pulmonary-disease-a-population-based-cross-sectional-study
#9
Hyun-Young Shin, Hee-Jin Hwang, Jae Ho Chung
This study aimed to investigate the factors associated with vaccination coverage among chronic obstructive pulmonary disease (COPD) patients in Korea using the fourth to the sixth Korean National Health and Nutrition Examination Surveys (KNHANES IV, V, VI). A total of 16 812 subjects aged 40 years and older who underwent spirometry and had an "influenza vaccination history" were analyzed. The vaccination rate of middle-aged (40-64 years) COPD patients was only 31.9%; whereas, the vaccination rate of elderly (65 years and older) COPD patients was 80...
October 2017: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/28979116/self-management-behaviors-to-reduce-exacerbation-impact-in-copd-patients-a-delphi-study
#10
Yvonne Jg Korpershoek, Joyce C Bruins Slot, Tanja W Effing, Marieke J Schuurmans, Jaap Ca Trappenburg
BACKGROUND: Little is known about which self-management behaviors have the highest potential to influence exacerbation impact in COPD patients. We aimed to reach expert consensus on the most relevant set of self-management behaviors that can be targeted and influenced to maximize reduction of exacerbation impact. MATERIALS AND METHODS: A 2-round Delphi study was performed using online surveys to rate the relevance and feasibility of predetermined self-management behaviors identified by literature and expert opinion...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28965921/therapeutic-approaches-of-asthma-and-copd-overlap
#11
REVIEW
Mitsuko Kondo, Jun Tamaoki
Asthma and COPD overlap (ACO) is an important clinical phenotype, due to the low-health-related quality of life (QOL), rapid decline in lung function, frequent exacerbation, and high economic burden. However, no large-scaled therapeutic trials of ACO have been conducted. At present, ACO is treated according to asthma/COPD guidelines. The goals of ACO treatment are to relieve symptoms and improve QOL and lung functions. Treatment must also prevent disease progression, airway remodeling, exacerbation, complications, and comorbidities...
September 28, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28927683/influenza-vaccination-and-risk-of-respiratory-failure-in-patients-with-chronic-obstructive-pulmonary-disease-a-nationwide-population-based-case-cohort-study
#12
Hsin-Hui Huang, Su-Jung Chen, Tze-Fan Chao, Chia-Jen Liu, Tzeng-Ji Chen, Pesus Chou, Fu-Der Wang
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease which causes a considerable disease burden. Patients with COPD are at a higher risk for influenza infection and influenza vaccination are recommended at this high risk patient group. In the current study, we aimed to evaluate the association between influenza vaccination and the risk of respiratory failure (RF) in COPD patients. METHODS: From 2001 to 2005, patients with newly diagnosed COPD were identified from the NHIRD, and were followed until 2010...
September 6, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28925418/mhealth-application-areas-and-technology-combinations-a-comparison-of-literature-from-high-and-low-middle-income-countries
#13
Haitham Abaza, Michael Marschollek
BACKGROUND: With the continuous and enormous spread of mobile technologies, mHealth has evolved as a new subfield of eHealth. While eHealth is broadly focused on information and communication technologies, mHealth seeks to explore more into mobile devices and wireless communication. Since mobile phone penetration has exceeded other infrastructure in low and middle-income countries (LMICs), mHealth is seen as a promising component to provide pervasive and patient-centered care. OBJECTIVES: The aim of our research work for this paper is to examine the mHealth literature to identify application areas, target diseases, and mHealth service and technology types that are most appropriate for LMICs...
August 8, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28893369/virulence-determinants-of-moraxella-catarrhalis-distribution-and-considerations-for-vaccine-development
#14
Luke V Blakeway, Aimee Tan, Ian R A Peak, Kate L Seib
Moraxella catarrhalis is a human-restricted opportunistic bacterial pathogen of the respiratory mucosa. It frequently colonizes the nasopharynx asymptomatically, but is also an important causative agent of otitis media (OM) in children, and plays a significant role in acute exacerbations of chronic obstructive pulmonary disease (COPD) in adults. As the current treatment options for M. catarrhalis infection in OM and exacerbations of COPD are often ineffective, the development of an efficacious vaccine is warranted...
September 12, 2017: Microbiology
https://www.readbyqxmd.com/read/28889955/impaired-humoral-and-cellular-immune-responses-to-influenza-vaccination-in-chronic-obstructive-pulmonary-disease-patients
#15
Aurélien Parpaleix, Laurent Boyer, Aurelie Wiedemann, Christine Lacabaratz, Laurent Margarit, Vincent Enouf, Philippe Le Corvoisier, Anne Lino, Ala Covali-Noroc, Bruno Housset, Christos Chouaid, Bernard Maitre, Yves Lévy, Jean-Daniel Lelièvre, Serge Adnot
No abstract text is available yet for this article.
December 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28854845/role-of-streptococcus-pneumoniae-infection-in-chronic-obstructive-pulmonary-disease-patients-in-italy
#16
Marco Mantero, Stefano Aliberti, Chiara Azzari, Maria Moriondo, Francesco Nieddu, Francesco Blasi, Marta Di Pasquale
BACKGROUND: The aim of this study was to determine the incidence of exacerbations due to Streptococcus pneumoniae in chronic obstructive pulmonary disease (COPD) patients during stable state. METHODS: We conducted a prospective, observational, cohort study including stable COPD patients, who were evaluated at least every 4 months over a 24-month period at the Respiratory Unit of the IRCCS Policlinico Hospital in Milan, Italy, from 2012 to 2015. Sputum samples were collected at enrollment during stable state to evaluate the frequency of S...
October 2017: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/28853985/a-moraxella-catarrhalis-vaccine-to-protect-against-otitis-media-and-exacerbations-of-copd-an-update-on-current-progress-and-challenges
#17
Antonia C Perez, Timothy F Murphy
Moraxella catarrhalis is a major cause of morbidity and mortality worldwide, especially causing otitis media in young children and exacerbations of chronic obstructive pulmonary disease in adults. This pathogen uses several virulence mechanisms to colonize and survive in its host, including adherence and invasion of host cells, formation of polymicrobial biofilms with other bacterial pathogens, and production of β-lactamase. Given the global impact of otitis media and COPD, an effective vaccine to prevent M...
October 3, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28852915/evaluation-of-pharmacist-initiated-interventions-on-vaccination-rates-in-patients-with-asthma-or-copd
#18
Haley M Klassing, Janelle F Ruisinger, Emily S Prohaska, Brittany L Melton
To determine if pharmacy-initiated interventions improved the rate of influenza and pneumococcal vaccinations in adult patients with asthma and/or chronic obstructive pulmonary disease (COPD). Adult patients who filled prescriptions at one of three community pharmacies, who had a dispensing history indicative of an asthma and/or COPD diagnosis were randomized to receive a personal phone call or standardized mailed letter recommending influenza and pneumococcal vaccinations, or control with no vaccination information...
August 29, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28729620/self-management-behaviour-and-support-among-primary-care-copd-patients-cross-sectional-analysis-of-data-from-the-birmingham-chronic-obstructive-pulmonary-disease-cohort
#19
Ainee Khan, Andrew P Dickens, Peymane Adab, Rachel E Jordan
Self-management support for chronic obstructive pulmonary disease (COPD) patients is recommended by UK national guidelines, but extent of implementation is unknown. We aimed to describe self-management behaviour and support among COPD patients and explore behaviour associated with having a self-management plan. We undertook cross-sectional analysis of self-reported data from diagnosed COPD patients in the Birmingham COPD Cohort study. Questionnaire items relevant to self-management behaviour, knowledge of COPD, receipt of self-management plans and advice from healthcare professionals were examined...
July 20, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28719225/association-between-social-support-and-self-care-behaviors-in-adults-with-chronic-obstructive-pulmonary-disease
#20
Zijing Chen, Vincent S Fan, Basia Belza, Kenneth Pike, Huong Q Nguyen
RATIONALE: Higher social support is associated with a better quality of life and functioning in adults with chronic obstructive pulmonary disease (COPD). OBJECTIVES: To determine the association between structural and functional social support and self-care behaviors in adults with COPD. METHODS: This was a longitudinal study using data from the CASCADE (COPD Activity: Serotonin Transporter, Cytokines, and Depression) study, which was focused on depression and functioning in COPD...
September 2017: Annals of the American Thoracic Society
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