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cancer, palliative radiotherapy, locally advanced, head neck

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https://www.readbyqxmd.com/read/27561463/safety-of-drug-treatments-for-head-and-neck-cancer
#1
Rachel Galot, Jean-Pascal Machiels
INTRODUCTION: The treatment of squamous cell carcinoma of the head and the neck depends on the disease's stage. In locally-advanced stage disease, multimodal treatment strategies, including surgery, radiotherapy and chemotherapy, give the best outcome in terms of overall survival. Those treatments are not without negligeable adverse events, which can lead to late debilitating toxicities. In recurrent/metastatic disease, not amenable to surgery or radiation therapy, palliative chemotherapy is the most appropriate treatment...
September 9, 2016: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/27146764/twice-weekly-palliative-radiotherapy-for-locally-very-advanced-head-and-neck-cancers
#2
V Murthy, D P Kumar, A Budrukkar, T Gupta, S Ghosh-Laskar, J Agarwal
PURPOSE: The purpose of the following study is to evaluate the efficacy of a twice-weekly hypofractionated palliative radiotherapy schedule in locally very advanced head and neck cancers. MATERIALS AND METHODS: Patients with locally very advanced, head and neck cancers were prospectively evaluated after twice-weekly palliative radiotherapy regimen of 32 Gy in 8 fractions. Median age was 55.5 years and the predominant primary site was oral cavity (46%). Majority (70...
January 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/27057882/curative-intent-aggressive-treatment-improves-survival-in-elderly-patients-with-locally-advanced-head-and-neck-squamous-cell-carcinoma-and-high-comorbidity-index
#3
COMPARATIVE STUDY
Jin-Hua Chen, Yu-Chun Yen, Hsuan-Chia Yang, Shing-Hwa Liu, Sheng-Po Yuan, Li-Li Wu, Fei-Peng Lee, Kuan-Chou Lin, Ming-Tang Lai, Chia-Che Wu, Tsung-Ming Chen, Chia-Lun Chang, Jyh-Ming Chow, Yi-Fang Ding, Szu-Yuan Wu
For locally advanced head and neck squamous cell carcinoma (HNSCC), therapeutic decisions depend on comorbidity or age. We estimated the treatment outcomes of patients with different Charlson comorbidity index (CCI) scores and ages to determine whether aggressive treatment improves survival.Data from the Taiwan National Health Insurance and cancer registry databases were analyzed, and we included >20-year-old patients with American Joint Committee on Cancer (AJCC) stage III or IV HNSCC (International Classification of Diseases, Ninth Revision, Clinical Modification codes 140...
April 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27042308/magnetic-resonance-guided-high-intensity-focused-ultrasound-combined-with-radiotherapy-for-palliation-of-head-and-neck-cancer-a-pilot-study
#4
Justin Lee, Georges Farha, Ian Poon, Irene Karam, Kevin Higgins, Samuel Pichardo, Kullervo Hynynen, Danny Enepekides
BACKGROUND: Radiotherapy is a critical component of the multidisciplinary management of cancers of the head and neck. It may comprise the primary curative treatment modality or is used in an adjuvant setting to improve local control and survival by preventing seeding and reseeding of distant metastases from persistent reservoirs of locoregional disease. Although considerable advances have been made recently in the fields of radiotherapy, systemic treatment and surgery for head and neck tumours, locoregional recurrence rates remain high and treatment side effects may have severe impact on patients' quality of life...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/26870840/cyclical-hypofractionated-radiotherapy-technique-for-palliative-treatment-of-locally-advanced-head-and-neck-cancer-institutional-experience-and-review-of-palliative-regimens
#5
Teresa S Finnegan, Neal H Bhatt, Joseph N Shaughnessy, Cesar Perez, Rebecca Redman, Craig Silverman, Jeffrey Bumpous, Kevin Potts, Neal E Dunlap
BACKGROUND: Effective palliation in patients with locally advanced head and neck cancer is important. Cyclical hypofractionated radiotherapy (Quad Shot) is a short-course palliative regimen with good patient compliance, low rates of acute toxicity, and delayed late fibrosis. OBJECTIVE: To review use of the Quad Shot technique at our institution in order to quantify the palliative response in locally advanced head and neck cancer. METHODS: The medical records of 70 patients with head and neck squamous cell carcinoma who had been treated with the Quad Shot technique were analyzed retrospectively (36 had been treated with intensity-modulated radiation therapy and 34 with 3-D conformal radiotherapy)...
January 2016: Journal of Community and Supportive Oncology
https://www.readbyqxmd.com/read/26303014/a-phase-2-randomized-study-to-compare-short-course-palliative-radiotherapy-with-short-course-concurrent-palliative-chemotherapy-plus-radiotherapy-in-advanced-and-unresectable-head-and-neck-cancer
#6
Arvind Kumar, Atul Sharma, Bidhu Kalyan Mohanti, Alok Thakar, Nootan Kumar Shukla, Sanjay P Thulkar, Kapil Sikka, Suman Bhasker, Chirom Amit Singh, Sreenivas Vishnubhatla
BACKGROUND: Treatment of unresectable HNSCC is not well defined and has a poor outcome. This study has been designed to address the unmet needs of such groups of patients with primary end points of (a) proportion of patients eligible for radical treatment in each arm (b) loco-regional disease control at 6months between two arms. MATERIALS AND METHODS: Locally advanced and unresectable HNSCC patients (except Nasopharynx and Larynx) unfit for radical treatment were randomized to arm A [short course RT alone (4Gy/#/day for 5days)] or arm B [RT as arm A+concurrent cisplatin at 6mg/m(2)/day IV bolus for 5days]...
October 2015: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/25832897/prevalence-of-oral-mucositis-dry-mouth-and-dysphagia-in-advanced-cancer-patients
#7
MULTICENTER STUDY
Sebastiano Mercadante, Federica Aielli, Claudio Adile, Patrizia Ferrera, Alessandro Valle, Flavio Fusco, Amanda Caruselli, Claudio Cartoni, Pizzuto Massimo, Francesco Masedu, Marco Valenti, Giampiero Porzio
BACKGROUND: Oral symptoms can be a sign of an underlying systemic condition and have a significant impact on quality of life, nutrition, and cost of care, while these lesions are often studied in the context of cancer treatment. However, information regarding oral symptoms in advanced cancer patients is poor. The aim of this multicenter study was to determine the prevalence and the characteristics of oral symptoms in a large population of advanced cancer patients. METHODS: A consecutive sample of patients with advanced cancer for a period of 6 months was prospectively assessed for an observational study...
November 2015: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/25735365/end-stage-palliative-care-of-head-and-neck-cancer-a-case-study
#8
Nitin Pratap Shishodia, Darshan Devang Divakar, Abdulaziz Abdullah Al Kheraif, Ravikumar Ramakrishnaiah, Akbar Ali Khan Pathan, Narasimha Reddy Parine, Santhosh Vediyera Chandroth, Binu Purushothaman
BACKGROUND: Locally advanced head and neck cancer is generally incurable and has a short survival rate. This study aimed to evaluate symptom relief, disease response, and acute toxicity after palliative hypo-fractionated radiotherapy and long-term survival in affected patients. MATERIALS AND METHODS: Between January 2011 to December 2011, 80 patients who were histopathologically diagnosed as having stage III or stage IV head and neck squamous cell carcinoma based on Eastern Cooperative Oncology Group (ECOG) performance status 1-3, were offered palliative radiotherapy (20 Gy/5Fr/5 Days)...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/25694259/0-7-21-hypofractionated-palliative-radiotherapy-an-effective-treatment-for-advanced-head-and-neck-cancers
#9
N-T A Nguyen, L Doerwald-Munoz, H Zhang, D-H Kim, S Sagar, J R Wright, D I Hodson
OBJECTIVE: We report our experience in providing palliative radiotherapy (RT) to patients with head and neck cancers (HNCs). Our hypofractionated regimen, "0-7-21", treats patients with 24 Gy in three fractions. METHODS: Patients, disease and response data were retrieved for candidates of 0-7-21 from 2005 to 2012. Primary end points included symptom and tumour size responses to RT based on response evaluation criteria in solid tumours (RECIST) guidelines. Secondary end points included progression-free survival (PFS) within the irradiated field, overall survival (OS) and symptomatic PFS (SPFS), calculated using Kaplan-Meier method and adverse events...
May 2015: British Journal of Radiology
https://www.readbyqxmd.com/read/25352967/palliative-hypo-fractionated-radiotherapy-in-locally-advanced-head-and-neck-cancer-with-fixed-neck-nodes
#10
Rajan Paliwal, Arvind Kumar-Patidar, Rahul Walke, Pushpendra Hirapara, Sandeep Jain, Megh Raj-Bardia
BACKGROUND: The locally advanced head and neck cancer with fixed nodes are incurable and has a short survival. This study aims to evaluate the symptom relief, disease response and acute toxicity after palliative hypo-fractionated radiotherapy. METHODS: Between December 2010 to June 2011, previously untreated 50 patients who had histopathologically proved of head and neck squamous cell carcinoma with fixed node of stage IV, Eastern Cooperative Oncology Group (ECOG) performance status 2-3 were offered palliative radiotherapy (20 Gy/5Fr/5 Days)...
2012: Iranian Journal of Cancer Prevention
https://www.readbyqxmd.com/read/24746747/patterns-of-practice-in-palliative-radiotherapy-in-africa-case-revisited
#11
B Jeremic, V Vanderpuye, S Abdel-Wahab, P Gaye, L Kochbati, M Diwani, P Emwula, B Oro, K Lishimpi, J Kigula-Mugambe, D Dawotola, T Wondemagegnehu, C Nyongesa, N Oumar, A El-Omrani, T Shuman, L Langenhoven, L Fourie
AIMS: To investigate patterns of practice in palliative radiotherapy in Africa. MATERIALS AND METHODS: Fifteen centres in Africa provided detailed information about radiotherapy in both metastatic and locally advanced disease via a questionnaire. Information included general information (institution status, equipment, staff, patient number), radiotherapy and other treatment characteristics in bone metastasis, brain metastasis, metastatic spinal cord compression, lung and liver metastasis, as well as locally advanced tumours...
June 2014: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/24347903/palliative-radiotherapy-in-locally-advanced-head-and-neck-cancer-after-failure-of-induction-chemotherapy-comparison-of-two-fractionation-schemes
#12
Kailash Chandra Pandey, Swaroop Revannasiddaiah, Nirdosh Kumar Pant, Vipul Nautiyal, Madhup Rastogi, Manoj Kumar Gupta
CONTEXT: Among patients with locally advanced head and neck squamous cell cancers (LAHNSCC), the prognosis after nonresponse or progression despite induction chemotherapy (IC) is dismal, and further treatment is often palliative in intent. Given that nonresponse to chemotherapy could indicate subsequent radioresistance, we intended to assess the outcomes with two different fractionation schemes. AIMS: To compare the outcomes of two fractionation schemes- 'standard' (consisting 3GyX5 daily fractions for 2 consecutive weeks) versus 'hybrid' (6GyX3 fractions on alternate days during the 1(st) week, followed by 2GyX5 daily fractions in the 2(nd) week)...
September 2013: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/24326849/recurrence-due-to-neoplastic-seeding-in-head-and-neck-cancer-report-of-two-cases-and-review-of-the-literature
#13
REVIEW
Lluís Nisa, Kaouthar Khanfir, Roland Giger
AIMS AND BACKGROUND: Tumor progression due to seeding of tumor cells after definitive treatment for squamous cell carcinomas of the head and neck is an uncommon condition that can considerably worsen the outcome of patients with head and neck cancer. METHODS AND STUDY DESIGN: We report two cases of recurrence due to neoplastic seeding from oropharyngeal and oral cancer, respectively. We performed a literature review with MEDLINE as the main search engine. RESULTS: Seeding was found to occur most often in tracheotomy scars and gastrostomy sites...
July 2013: Tumori
https://www.readbyqxmd.com/read/24049349/hypofractionated-palliative-radiotherapy-in-locally-advanced-inoperable-head-and-neck-cancer-cmc-vellore-experience
#14
Saikat Das, Solly Thomas, Suparna Kanti Pal, Rajesh Isiah, Subhashini John
BACKGROUND: A novel, short duration, palliative radiotherapy schedule for inoperable head and neck cancer was evaluated in terms of palliation of cancer-related symptoms and acute toxicities. MATERIALS AND METHODS: Thirty-six patients with inoperable head and neck cancer were included in the study (2010-2012). All patients received 40 Gy in 10 fractions (equivalent dose: 49.8 Gy in conventional fractionation) with 2 fractions per week. Treatment-related toxicity was assessed using Radiation Therapy Oncology Group criteria...
May 2013: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/23982853/seom-clinical-guidelines-for-the-treatment-of-head-and-neck-cancer-hnc-2013
#15
R Mesía, M Pastor, J J Grau, E del Barco
Head and neck cancer represents 5 % of oncologic cases in adults. Early stage treatments are local with surgery and/or radiotherapy. For locally advanced stages, treatment requires radiotherapy combined with platinum-based drugs or cetuximab. Induction chemotherapy should be considered for selected cases. In the case of metastatic disease, adjuvant or palliative treatment is based on platinum agents and cetuximab.
December 2013: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/23320055/systemic-therapy-strategies-for-head-neck-carcinomas-current-status
#16
Thomas K Hoffmann
Head and neck cancers, most of which are squamous cell tumours, have an unsatisfactory prognosis despite intensive local treatment. This can be attributed, among other factors, to tumour recurrences inside or outside the treated area, and metastases at more distal locations. These tumours therefore require not only the standard surgical and radiation treatments, but also effective systemic modalities. The main option here is antineoplastic chemotherapy, which is firmly established in the palliative treatment of recurrent or metastatic stages of disease, and is used with curative intent in the form of combined simultaneous or adjuvant chemoradiotherapy in patients with inoperable or advanced tumour stages...
2012: GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery
https://www.readbyqxmd.com/read/23289496/stereotactic-body-radiation-therapy-in-the-re-irradiation-situation-a-review
#17
REVIEW
Frederick Mantel, Michael Flentje, Matthias Guckenberger
Although locoregional relapse is frequent after definitive radiotherapy (RT) or multimodal treatments, re-irradiation is only performed in few patients even in palliative settings like e.g. vertebral metastasis. This is most due to concern about potentially severe complications, especially when large volumes are exposed to re-irradiation. With technological advancements in treatment planning the interest in re-irradiation as a local treatment approach has been reinforced. Recently, several studies reported re-irradiation for spinal metastases using SBRT with promising local and symptom control rates and simultaneously low rates of toxicity...
2013: Radiation Oncology
https://www.readbyqxmd.com/read/23267152/interstitial-hdr-brachytherapy-for-advanced-recurrent-squamous-cell-carcinoma-of-the-head-and-neck
#18
Susanne Wiegand, Andreas M Sesterhenn, Annette P Zimmermann, Gerd Strassmann, Thomas Wilhelm, Jochen A Werner
BACKGROUND: Surgical treatment remains the mainstay therapy for recurrence of head and neck cancer after previous radiotherapy. In inoperable cases, interstitial high-dose rate brachytherapy is a treatment option for local dose escalation. PATIENTS AND METHODS: A retrospective analysis of all patients who were treated solely with brachytherapy for advanced non-resectable recurrences of squamous cell carcinomas of the head and neck and who previously received radiotherapy was performed...
January 2013: Anticancer Research
https://www.readbyqxmd.com/read/22456917/-systemic-therapy-strategies-for-head-neck-carcinomas-current-status
#19
REVIEW
T K Hoffmann
Head and neck cancers, most of which are squamous cell tumours, have an unsatisfactory prognosis despite intensive local treatment. This can be attributed, among other factors, to tumour recurrences inside or outside the treated area, and metastases at more distal locations. These tumours therefore require not only the standard surgical and radiation treatments, but also effective systemic treatment. The main option here is antineoplastic chemotherapy, which is firmly established in the palliative treatment of recurrent or metastatic stages of disease, and is used with curative intent in the form of combined simultaneous or adjuvant chemoradiotherapy in patients with inoperable or advanced tumour stages...
March 2012: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/22078287/-the-results-and-toxicity-of-organ-preservation-treatment-for-locoregionally-advanced-laryngeal-and-hypopharyngeal-cancer
#20
Dorota Kiprian, Andrzej Kawecki, Andrzej Jarząbski, Wojciech Michalski, Beata Pawłowska-Sendułka
UNLABELLED: The most frequent malignant tumor of the head and neck region is a squamous cell cancer of the larynx. Squamous cell cancer of the hypopharynx is diagnosed rarely, but it has poorer prognosis than laryngeal cancer. The surgical treatment, especially in advanced disease, is a laryngectomy with the definitive tracheostomy, what negatively influenced the quality of life. Therefore, oncologists have been interested in new alternative methods of conservative treatment from many years...
September 2011: Otolaryngologia Polska. the Polish Otolaryngology
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