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https://www.readbyqxmd.com/read/29780493/impact-of-helical-organization-on-the-photovoltaic-properties-of-oligothiophene-supramolecular-polymers
#1
Hayato Ouchi, Takahiro Kizaki, Masaki Yamato, Xu Lin, Nagahiro Hoshi, Fabien Silly, Takashi Kajitani, Takanori Fukushima, Ken-Ichi Nakayama, Shiki Yagai
Helical self-assembly of functional π-conjugated molecules offers unique photochemical and electronic properties in the spectroscopic level, but there are only a few examples that demonstrate their positive impact on the optoelectronic device level. Here, we demonstrate that hydrogen-bonded tapelike supramolecular polymers of a barbiturated oligo(alkylthiophene) show notable improvement in their photovoltaic properties upon organizing into helical nanofibers. A tapelike hydrogen-bonded supramolecular array of barbiturated oligo(butylthiophene) molecules was directly visualized by STM at a liquid-solid interface...
April 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29774192/efficacy-of-the-all-in-one-therapeutic-strategy-for-severe-traumatic-brain-injury-preliminary-outcome-and-limitation
#2
Young-Soo Park, Yohei Kogeichi, Yoichi Shida, Hiroyuki Nakase
Objective: Despite recent advances in medicine, no significant improvement has been achieved in therapeutic outcomes for severe traumatic brain injury (TBI). In the treatment of severe multiple traumas, accurate judgment and prompt action corresponding to rapid pathophysiological changes are required. Therefore, we developed the "All-in-One" therapeutic strategy for severe TBI. In this report, we present the therapeutic concept and discuss its efficacy and limitations. Methods: From April 2007 to December 2015, 439 patients diagnosed as having traumatic intracranial injuries were treated at our institution...
April 2018: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29773359/-psychoactive-substances-use-in-r%C3%A3-union-island-and-mayotte-french-departments-in-indian-ocean
#3
Amélie Daveluy, Françoise Haramburu
INTRODUCTION: The government plan for the fight against drugs and addictive behaviors 2013-2017 includes several actions concerning French overseas territories, in particular to strengthen information on drug addiction. The Interministerial mission for combating drugs and addictive behaviors (MILD&CA) has commissioned the Bordeaux addictovigilance center to strengthen exchanges on addictovigilance with Réunion Island and Mayotte and to make an inventory of problematic drug use in these two French departments of Indian Ocean...
February 27, 2018: Thérapie
https://www.readbyqxmd.com/read/29760859/substance-use-in-pregnant-women-using-the-emergency-department-undertested-and-overlooked
#4
C Leigh Moyer, Sean Johnson, Marilyn G Klug, Larry Burd
Introduction: The objective was to determine if pregnant women visiting the emergency department (ED) are tested for substance use as frequently as non-pregnant women. Methods: We captured all ED visits over a six-year period (2010-2016) from a single community hospital and identified women of childbearing age, defined for our study as 11-50 years old. We collected demographic data including age in years, ethnicity, body mass index, marital status, disposition, last encounter department, method of arrival, and day of week...
May 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29744526/-drugs-for-intravenous-induction-of-anesthesia-barbiturates
#5
C Dumps, E Halbeck, D Bolkenius
The discovery of barbituric acid and research on its derivatives have long been of importance in advancements in modern anesthesia. Decades of clinical use of barbiturates worldwide and their abuse has led to an enormous amount of knowledge. Thiopental and methohexital are ultra-short acting derivatives of barbiturates. Their clinical application has been accompanied by an enormous increase in the knowledge of the pharmacology of cerebrally active drugs, in particular gamma-aminobutyric acid (GABAA ) receptor and GABA-induced effects on nerve cell membranes...
May 9, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29663484/association-between-psychotropic-medications-and-presence-of-sleep-bruxism-a-systematic-review
#6
REVIEW
Gilberto Melo, Kamile Leonardi Dutra, Rubens Rodrigues Filho, Adriana de Oliveira Lira Ortega, André Luís Porporatti, Bruce Dick, Carlos Flores-Mir, Graziela De Luca Canto
The purpose of this study was to systematically review the literature for studies that investigated the association between use of psychotropic medications and presence of sleep bruxism (SB). Observational studies were selected in a two-phase process. Searches were performed on six electronic databases and a grey literature search was conducted on three databases. SB diagnosis was based on questionnaires or clinical examinations; no polysomnography exams were performed. Risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Analytical Cross-Sectional Studies...
April 16, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29616806/dynamic-covalent-metathesis-in-the-c%C3%A2-c-c%C3%A2-n-exchange-between-knoevenagel-compounds-and-imines
#7
Ruirui Gu, Karolina Flidrova, Jean-Marie Lehn
Fast and reversible dynamic covalent C═C/C═N exchange takes place without catalyst in nonpolar solvents between barbiturate-derived Knoevenagel (Kn) compounds and imines. A detailed study of the reaction indicates that it proceeds by an associative organo-metathesis mechanism involving the formation of a four-membered ring azetidine intermediate by addition of the imine C═N group to the C═C bond of the Kn compound. This intermediate could be generated cleanly and stabilized at low temperature by condensation of the o,p-dinitrophenyl Kn derivative with the cyclic imine 1-azacyclohexene...
April 25, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29596288/management-of-intracranial-pressure-part-i-pharmacologic-interventions
#8
Tara L Sacco, Samantha A Delibert
Dangerous, sustained elevation in intracranial pressure (ICP) is a risk for any patient following severe brain injury. Intracranial pressure elevations that do not respond to initial management are considered refractory to treatment, or rICP. Patients are at significant risk of secondary brain injury and permanent loss of function resulting from rICP. Both nonpharmacologic and pharmacologic interventions are utilized to intervene when a patient experiences either elevation in ICP or rICP. In part 1 of this 2-part series, pharmacologic interventions are discussed...
May 2018: Dimensions of Critical Care Nursing: DCCN
https://www.readbyqxmd.com/read/29537897/a-descriptive-analysis-of-drugged-driving-among-rural-dui-offenders
#9
J Matthew Webster, Megan F Dickson, Michele Staton
OBJECTIVE: Although driving under the influence (DUI) arrests occur at higher rates in rural areas and previous studies have shown more extensive drug use histories, little is known about how this relates to the prevalence and frequency of drugged driving. The present study examined drug use and drugged driving patterns among a sample of rural DUI offenders. METHODS: Convicted, rural DUI offenders (N = 118) completed a one-time, confidential research interview focused on drug use and drugged driving...
March 14, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29527046/kilpauk-mental-hospital-the-bethlem-of-south-asia-a-recall-of-its-history-prior-to-1970
#10
O Somasundaram, Ponnudurai Ratnaraj
Period of Custodial Care Only: The magnificent "Institute of Mental Health" has its history almost from 1795 when the East India company appointed Surgeon Valentine Conolly to be in charge of a "House for accommodating persons of unsound mind." After a few transitions, backed by a government order for the construction of a lunatic asylum in a 66 1/2 acre site, the asylum started functioning from 1871. The period of about six decades from its inception could be referred to as "the period of custodial care...
February 2018: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/29507852/pitfall-in-pupillometry-exaggerated-ciliospinal-reflex-in-a-patient-in-barbiturate-coma-mimicking-a-nonreactive-pupil
#11
Naresh Mullaguri, Nakul Katyal, Aarti Sarwal, Jonathan M Beary, Pravin George, Naresh Karthikeyan, Premkumar Nattanamai, Christopher R Newey
Although a neurological examination is fundamental to the evaluation of comatose patients, it is less reliable in a medically induced coma. A commonly misinterpreted finding in patients in a pentobarbital coma is altered pupillary reactivity secondary to an exaggerated ciliospinal reflex. Recognizing an exaggerated ciliospinal reflex in patients in a pentobarbital coma is important and may prevent unnecessary intervention. We present a patient induced in a pentobarbital coma for the treatment of status epilepticus who exhibited a nonreactive pupil secondary to an exaggerated ciliospinal reflex confirmed by pupillometry...
December 30, 2017: Curēus
https://www.readbyqxmd.com/read/29492491/barbituric-acid-modified-graphitic-carbon-nitride-nanosheets-for-ratiometric-fluorescent-detection-of-cu-2
#12
Ling Chen, Zhiping Song, Xueting Liu, Liangqia Guo, Mei-Jin Li, Fengfu Fu
In this work, barbituric acid-modified graphitic carbon nitride (BCN) nanosheets with blue-green fluorescence were prepared by a copolymerization of dicyandiamide with barbituric acid and then by a chemical oxidation process. A ratiometric fluorescent sensor for Cu2+ was designed by using BCN nanosheets as the report probe and Ru(bpy)3Cl2 as the reference probe. In the presence of different concentrations of Cu2+, the blue-green fluorescence of BCN nanosheets was drastically quenched, while the red fluorescence of Ru(bpy)3Cl2 remained constant...
March 26, 2018: Analyst
https://www.readbyqxmd.com/read/29476750/functional-relationship-between-brainstem-putative-pain-facilitating-neurons-and-spinal-nociceptfive-neurons-during-development-of-inflammation-in-rats
#13
Rafael Salas, Karla Ramirez, Victor Tortorici, Horacio Vanegas, Enrique Vazquez
The so-called on- and off-cells of the rostral ventromedial medulla (RVM) send their axons to the spinal dorsal horn. Activation of on-cells precedes and coincides with a facilitation, and activation of off-cells coincides with an inhibition, of withdrawal reflexes elicited by noxious agents. Considerable evidence supports the notion that on- and off-cells modulate nocifensive reflexes during opioid and non-opioid action and also during normal circumstances and during peripheral neuropathy and inflammation...
May 1, 2018: Brain Research
https://www.readbyqxmd.com/read/29472424/pentobarbital-induced-lactic-acidosis-following-status-epilepticus-barbiturate-coma
#14
Todd Rabkin Golden, Veronika Solnicky, Rita Wadeea, Sehem Ghazala
We present a rare case of pentobarbital infusion causing propylene glycol-induced lactic acidosis, during refractory status epilepticus treatment in a 66-year-old man without seizure history.
February 22, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29449106/hair-analysis-in-toxicological-investigation-of-drug-facilitated-crimes-in-denmark-over-a-8-year-period
#15
Xin Wang, Sys Stybe Johansen, Marie Katrine Klose Nielsen, Kristian Linnet
Hair can serve as a specimen for identifying past drug exposure. Segmental hair analysis may differentiate a single exposure from chronic use. Consequently, segmental hair analysis is useful for disclosing a single drug ingestion, as well as for determining repeated exposures in drug-facilitated crimes (DFCs). This paper presents an overview of toxicological investigations that have used hair analysis in DFC cases from 2009 to 2016 in Denmark. Hair concentrations were determined for 24 DFC-related drugs and metabolites, including benzodiazepines and other hypnotics, antihistamines, opioid analgesics, antipsychotics, barbiturates, and illicit drugs from DFC cases...
April 2018: Forensic Science International
https://www.readbyqxmd.com/read/29446627/ultrabright-and-fluorogenic-probes-for-multicolor-imaging-and-tracking-of-lipid-droplets-in-cells-and-tissues
#16
Mayeul Collot, Tkhe Kyong Fam, Pichandi Ashokkumar, Orestis Faklaris, Thierry Galli, Lydia Danglot, Andrey S Klymchenko
Lipid droplets (LDs) are intracellular lipid-rich organelles that regulate the storage of neutral lipids and were recently found to be involved in many physiological processes, metabolic disorders, and diseases including obesity, diabetes, and cancers. Herein we present a family of new fluorogenic merocyanine fluorophores based on an indolenine moiety and a dioxaborine barbiturate derivative. These so-called StatoMerocyanines (SMCy) fluoresce from yellow to the near-infrared (NIR) in oil with an impressive fluorescence enhancement compared to aqueous media...
April 25, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29432946/postoperative-cerebral-infarction-risk-factors-and-postoperative-management-of-pediatric-patients-with-moyamoya-disease
#17
Shinsuke Muraoka, Yoshio Araki, Goro Kondo, Michihiro Kurimoto, Yoshiki Shiba, Kenji Uda, Shinji Ota, Sho Okamoto, Toshihiko Wakabayashi
OBJECTIVE: Although revascularization surgery for patients with moyamoya disease can effectively prevent ischemic events and thus improve the long-term clinical outcome, the incidence of postoperative ischemic complications affects patients' quality of life. This study aimed to clarify the risk factors associated with postoperative ischemic complications and to discuss the appropriate perioperative management. METHODS: Fifty-eight revascularization operations were performed in 37 children with moyamoya disease...
May 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29427609/tartrazine-induced-neurobiochemical-alterations-in-rat-brain-sub-regions
#18
Diksha Bhatt, Krati Vyas, Shakuntala Singh, P J John, Inderpal Soni
Tartrazine is a synthetic lemon yellow azo dye primarily used as a food coloring. The present study aimed to screen the neurobiochemical effects of Tartrazine in Wistar rats after administering the Acceptable Daily Intake (ADI) level. Tartrazine (7.5 mg/kg b.w.) was administered to 21 day old weanling rats through oral gavage once daily for 40 consecutive days. On 41st day, the animals were sacrificed and brain sub regions namely, frontal cortex, corpus striatum, hippocampus and cerebellum were used to determine activities of anti-oxidant enzymes viz...
March 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29419564/patient-factors-and-outcomes-associated-with-the-withdrawal-or-withholding-of-life-sustaining-therapies-in-mechanically-ventilated-brain-injured-patients-an-observational-multicentre-study
#19
Nicolas Nesseler, Antoine Roquilly, Sigismond Lasocki, Claire Dahyot-Fizelier, Yoann Launey, Cinotti Raphaël, Marine Hubert, Sonia Isslame, Pierre-François Perrigault, Thomas Geeraerts, Olivier Mimoz, Fouad Marhar, Yannick Mallédant, Fanny Feuillet, Karim Asehnoune, Philippe Seguin
BACKGROUND: Knowledge of the factors associated with the decision to withdraw or withhold life support (WWLS) in brain-injured patients is limited. However, most deaths in these patients may involve such a decision. OBJECTIVES: To identify factors associated with the decision to WWLS in brain-injured patients requiring mechanical ventilation who survive the first 24 h in the ICU, and to analyse the outcomes and time to death. DESIGN: A retrospective observational multicentre study...
February 3, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29419341/comparing-the-validity-of-self-report-and-urinalysis-for-substance-use-among-former-inmates-in-the-northeastern-united-states
#20
Jacob J van den Berg, Samuel Adeyemo, Mary B Roberts, Beth C Bock, L A R Stein, Rosemarie A Martin, Donna R Parker, Jennifer G Clarke
BACKGROUND: Problems with self-reported drug use include difficulties with recall and recognition as well as the desire to respond to questions in a socially desirable manner. Various methods have been developed to improve and/or validate estimates based on direct questioning of individuals regarding their substance use. For this study, we were interested in validating self-reported use of: 1) tobacco, 2) marijuana, and 3) other substances (i.e., heroin, cocaine, opiates, oxycodone, benzodiazepines, methamphetamine, phencyclidine, and barbiturates) employing urinalysis among inmates who participated in a randomized controlled trial of a smoking abstinence intervention in a tobacco-free prison located in the northeastern United States...
February 8, 2018: Substance Use & Misuse
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