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JOURNAL ARTICLE
Yicong Liang, Yue Kong, Menglan Rao, Xing Zhou, Chengcheng Li, Yi Meng, Yanxi Chen, Hongjian Li, Zhen Luo
Enterovirus 71 (EV71) causes hand-foot-and-mouth disease (HFMD), neurological complications, and even fatalities in infants. Clinically, the increase of extracellular vesicles (EVs) in EV71 patients' serum was highly associated with the severity of HFMD. EV71 boosts EVs biogenesis in an endosomal sorting complex required for transport (ESCRT)-dependent manner to facilitate viral replication. Yet, the impact of EVs-derived from ESCRT-independent pathway on EV71 replication and pathogenesis is highly concerned...
April 6, 2024: International Journal of Biological Macromolecules
#22
JOURNAL ARTICLE
Chen Yuan, Xue Zhao, Yawen Feng, Ligong Chen, Yidan Lin, Tanqing Li, Qinye Song
Porcine epidemic diarrhea virus (PEDV) is an acute, highly contagious enterovirus that infects pigs of all ages. The B cells are important for antigen presentation, antibody production, and cytokine secretion to resist infection. However, the role of B cells in PEDV infection remains unclear. In this study, the effects of PEDV virulent (QY2016) and attenuated strains (CV777) on B cells sorted from neonatal piglets, nursery piglets, and gilts were investigated. The results showed that PEDV-QY2016 and PEDV-CV777 could significantly increase the expression of CD54 and CD27 in B cells from neonatal piglets...
2024: Frontiers in Microbiology
#23
JOURNAL ARTICLE
Ya Li Zhang, Wen Zhe Su, Rui Chen Wang, Yan Li, Jun Feng Zhang, Sheng Hui Liu, Dan He Hu, Chong Xiao Xu, Jia Yu Yin, Qi Kai Yin, Ying He, Fan Li, Shi Hong Fu, Kai Nie, Guo Dong Liang, Yong Tao, Song Tao Xu, Chao Feng Ma, Huan Yu Wang
OBJECTIVE: Viral encephalitis is an infectious disease severely affecting human health. It is caused by a wide variety of viral pathogens, including herpes viruses, flaviviruses, enteroviruses, and other viruses. The laboratory diagnosis of viral encephalitis is a worldwide challenge. Recently, high-throughput sequencing technology has provided new tools for diagnosing central nervous system infections. Thus, In this study, we established a multipathogen detection platform for viral encephalitis based on amplicon sequencing...
March 20, 2024: Biomedical and Environmental Sciences: BES
#24
Henning Klapproth, Jonas Rauterberg, Sami Shabli, Steffi Silling, Sindy Böttcher, Esther von Stebut, Mario Fabri
No abstract text is available yet for this article.
April 6, 2024: Journal der Deutschen Dermatologischen Gesellschaft: JDDG
#25
JOURNAL ARTICLE
Arthur Felix, Zein Assad, Philippe Bidet, Marion Caseris, Cécile Dumaine, Albert Faye, Isabelle Melki, Florentia Kaguelidou, Zaba Valtuille, Naïm Ouldali, Ulrich Meinzer
IMPORTANCE: Henoch-Schönlein purpura (HSP) is the most common type of vasculitis in children. The factors that trigger the disease are poorly understood. Although several viruses and seasonal bacterial infections have been associated with HSP, differentiating the specific associations of these pathogens with the onset of HSP remains a challenge due to their overlapping seasonal patterns. OBJECTIVE: To analyze the role of seasonal pathogens in the epidemiology of HSP...
April 1, 2024: JAMA Network Open
#26
JOURNAL ARTICLE
Hiroyuki Sumikura, Mai Ito, Takuma Sato, Naoki Hatayama, Tomohiro Fujioka, Nozomi Nagashima, Yuki Shimada, Isao Fukasaka, Mikito Shimizu, Kyoko Higashida, Taku Hoshi, Keiko Tanaka, Manabu Sakaguchi
A 44-year-old woman with a subacute onset of an altered mental status, urinary retention, and fluctuating blood pressure was initially diagnosed with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis, meeting the criteria of Graus et al. Cardiac arrest occurred, which required pacemaker placement. She subsequently showed profound flaccid limb paralysis, with magnetic resonance imaging demonstrating focal necrotic lesions localized in the anterior horn of the longitudinal segments of the spinal cord and in the pontine tegmentum...
April 2, 2024: Internal Medicine
#27
JOURNAL ARTICLE
Kentaro Akata, Kei Yamasaki, Takako Kawaguchi, Yosuke Chiba, Konomi Sennari, Saki Shigemi, Kazuki Nemoto, Midori Funada, Katsunori Suzuki, Kazuhiro Yatera
BACKGROUND: Few studies have investigated the prevalence of pathogens in patients with acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF), specifically, the interactions between respiratory pathogens and AE-IPF during the coronavirus disease 2019 (COVID-19) pandemic. OBJECTIVES: We aimed to analyze pathogens in patients with AE-IPF between September 2020 and December 2022. METHODS: This retrospective observational study was conducted at our hospital between September 2020 and December 2022...
April 2, 2024: Heart & Lung: the Journal of Critical Care
#28
REVIEW
Yihan Chen, Zhengxin Chen, Yingying Zhu, Yuxi Wen, Chao Zhao, Wanmeng Mu
Gastrointestinal (GI)-associated viruses, including rotavirus (RV), norovirus (NV), and enterovirus, usually invade host cells, transmit, and mutate their genetic information, resulting in influenza-like symptoms, acute gastroenteritis, encephalitis, or even death. The unique structures of human milk oligosaccharides (HMOs) enable them to shape the gut microbial diversity and endogenous immune system of human infants. Growing evidence suggests that HMOs can enhance host resistance to GI-associated viruses but without a systematic summary to review the mechanism...
April 2, 2024: Journal of Agricultural and Food Chemistry
#29
Daryn E Erickson, Kyle M Simmons, Zachary A Barrand, Chase L Ridenour, Paige B Hawkinson, Lacey Lemke, Shayne P Sellner, Breezy N Brock, Alexis N Rivas, Krystal Sheridan, Darrin Lemmer, Hayley D Yaglom, W Tanner Porter, Monique Belanger, Rachel M Torrey, Aidan James R Stills, Kiley McCormack, Matt Black, Wydale Holmes, Drew Rostain, Jeremy Mikus, Kimberly Sotelo, Emmen Haq, Reshma Neupane, Joli Weiss, Jasmine Johnson, Clancey Collins, Sarah Avalle, Chelsi White, Brandon J Howard, Sara A Maltinsky, Ryann N Whealy, Nathaniel B Gordon, Jason W Sahl, Talima Pearson, Viacheslav Y Fofanov, Tara Furstenau, Elizabeth M Driebe, J Gregory Caporaso, Jarrett Barber, Joel Terriquez, David M Engelthaler, Crystal M Hepp
BACKGROUND: Most seasonally circulating enteroviruses result in asymptomatic or mildly symptomatic infections. In rare cases, however, infection with some subtypes can result in paralysis or death. Of the 300 subtypes known, only poliovirus is reportable, limiting our understanding of the distribution of other enteroviruses that can cause clinical disease. OBJECTIVE: The overarching objectives of this study were to: 1) describe the distribution of enteroviruses in Arizona during the late summer and fall of 2022, the time of year when they are thought to be most abundant, and 2) demonstrate the utility of viral pan-assay approaches for semi-agnostic discovery that can be followed up by more targeted assays and phylogenomics...
March 20, 2024: medRxiv
#30
JOURNAL ARTICLE
Bianca Klee, Sophie Diexer, Johannes Horn, Susan Langer, Marie Wende, Diego Ortiz, Agata Bielecka, Till Strowig, Rafael Mikolajczyk, Cornelia Gottschick
BACKGROUND: Effects of non-pharmaceutical interventions during the pandemic were mainly studied for severe outcomes. Among children, most of the burden of respiratory infections is related to infections which are not medically attended. The perspective on infections in the community setting is necessary to understand the effects of the pandemic on non-pharmaceutical interventions. METHODS: In the unique prospective LoewenKIDS cohort study, we compared the true monthly incidence of self-reported acute respiratory infections (ARI) in about 350 participants (aged 3-4 years old) between October 2019 to March 2020 (pre-pandemic period) and October 2020 to March 2021 (pandemic period)...
April 1, 2024: BMC Pediatrics
#31
REVIEW
Raiana S Machado, Fernando N Tavares, Ivanildo P Sousa
Coxsackieviruses-induced infections, particularly in infants and young children, are one of the most important public health issues in low- and middle-income countries, where the surveillance system varies substantially, and these manifestations have been disregarded. They are widespread throughout the world and are responsible for a broad spectrum of human diseases, from mildly symptomatic conditions to severe acute and chronic disorders. Coxsackieviruses (CV) have been found to have 27 identified genotypes, with overlaps in clinical phenotypes between genotypes...
March 30, 2024: Virus Research
#32
JOURNAL ARTICLE
Tim S Veth, Lonneke V Nouwen, Marleen Zwaagstra, Heyrhyoung Lyoo, Kathryn A Wierenga, Bart Westendorp, Maarten A F M Altelaar, Celia Berkers, Frank J M van Kuppeveld, Albert J R Heck
Picornaviridae represent a large family of single-stranded positive RNA viruses of which different members can infect both humans and animals. These include the enteroviruses (e.g., poliovirus, coxsackievirus, and rhinoviruses) as well as the cardioviruses (e.g., encephalomyocarditis virus (EMCV)). Picornaviruses have evolved to interact with, use, and/or evade cellular host systems to create the optimal environment for replication and spreading. It is known that viruses modify kinase activity during infection, but a proteome-wide overview of the (de)regulation of cellular kinases during picornavirus infection is lacking...
March 29, 2024: Molecular & Cellular Proteomics: MCP
#33
MULTICENTER STUDY
Xiaohan Yang, Yudan Wu, Hongyu Zhao, Pan Liu, Lihua Liang, Aihua Yin
BACKGROUND: Enteroviruses (EV) are common and can cause severe diseases, particularly in young children. However, the information of EV infection in infants in China is limited due to the vast population size and extensive geographical area of the country. Here, we conducted a retrospective multicenter analysis of available EV data to assess the current epidemiological situation in the infant population in southern China. METHODS: The study enrolled infants with suspected EV infection from 34 hospitals across 12 cities in southern China between 2019 to 2022, and the confirmation of EV was done using RT-PCR and VP1 gene sequencing...
December 2024: Virulence
#34
JOURNAL ARTICLE
C Galli, G Mazzola, M Arosio, L Pellegrinelli, A Boldrini, D Guarneri, E Lombarda, C Farina, D Cereda, E Pariani
OBJECTIVES: To report epidemiological and virological results of an outbreak investigation of influenza-like illness (ILI) among refugees in Northern Italy. STUDY DESIGN: Outbreak investigation of ILI cases observed among nearly 100 refugees in Northern Italy unvaccinated for influenza. METHODS: An epidemiological investigation matched with a differential diagnosis was carried out for each sample collected from ILI cases to identify 10 viral pathogens (SARS-CoV-2, influenza virus type A and B, respiratory syncytial virus, metapneumovirus, parainfluenza viruses, rhinovirus, enterovirus, parechovirus, and adenovirus) by using specific real-time PCR assays according to the Centers for Disease Control and Prevention (CDC) protocols...
March 29, 2024: Public Health
#35
JOURNAL ARTICLE
Martin Ng, Defres S, Willis L, Beckley R, Hardwick H, Coxon A, Kadambari S, Yu L-M, Liu X, Galal U, Conlin K, Griffiths Mj, Kneen R, Nadel S, Heath Pt, Kelly Df, Solomon T, Sadarangani M, Pollard Aj
OBJECTIVES: The aims of this study were to assess aetiology and clinical characteristics in childhood meningitis, and develop clinical decision rules to distinguish bacterial meningitis from other similar clinical syndromes. METHODS: Children aged <16 years hospitalised with suspected meningitis/encephalitis were included, and prospectively recruited at 31 UK hospitals. Meningitis was defined as identification of bacteria/viruses from cerebrospinal fluid (CSF) and/or a raised CSF white blood cell count...
March 27, 2024: Journal of Infection
#36
JOURNAL ARTICLE
Jen-Jan Hu, Da-Ling Wang, I-Shiang Tzeng
Respiratory tract infections are prevalent and clinically significant in pediatric populations globally. However, pathogen testing often involves time-consuming processes, resulting in delays in diagnosis. To date, commercial testing machines, such as the FilmArray respiratory panel, have been proposed for hospitals. Therefore, this study aimed to investigate the impact of the FilmArray respiratory panel at a single center. This study utilized the medical records of our hospital to select pediatric inpatients with respiratory tract infections who underwent the FilmArray respiratory panel between September 2020 and April 2021 and those who did not undergo nucleic acid detection (a rapid test group) between September 2019 and April 2020...
March 29, 2024: Medicine (Baltimore)
#37
JOURNAL ARTICLE
Jira Chansaenroj, Preeyaporn Vichaiwattana, Jiratchaya Puenpa, Thaksaporn Thatsanathorn, Natthinee Sudhinaraset, Nasamon Wanlapakorn, Yong Poovorawan
Human enterovirus (EV) and Parechovirus (PeV) infections are major causes of sepsis-like illness in infants < 90 days of age. Enterovirus species B (EV-B) was found to be the leading cause of aseptic meningitis in young infants. In Thailand, EV and PeV are not part of the routine screening of blood or cerebrospinal fluid (CSF) of children with suspected aseptic meningitis and sepsis-like illness. Consequently, data on EV and PeV epidemiology are limited. This study tested clinical samples from hospitalized young infants with suspected aseptic meningitis or sepsis-like illness between 2013 and 2022 for EV, PeV, and Herpes simplex virus (HSV)...
February 2024: Curēus
#38
JOURNAL ARTICLE
Zhiqiang Song, Yang Wang, Ping Liu, Yuke Geng, Na Liu, Jie Chen, Jianmin Yang
Chimeric antigen receptor T-cell (CAR-T) therapy has achieved durable response in patients with hematological malignancies, however, therapy-associated multisystem toxicities are commonly observed. Here, we systematically analyzed CAR-T-related gastrointestinal adverse events (GAEs) using the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) between January 2017 and December 2021. Disproportionality analyses were performed using reporting odds ratios (ROR) and information component (IC)...
March 28, 2024: Cancer Gene Therapy
#39
JOURNAL ARTICLE
Margarida Pires Simoes, Emma B Hodcroft, Peter Simmonds, Jan Albert, Enagon K Alidjinou, Katia Ambert-Balay, Cristina Andrés, Andrés Antón, Christelle Auvray, Jean-Luc Bailly, Fausto Baldanti, Capser Bastings, Stuart Beard, Carla Berengua Pereira, Natasa Berginc, Mandy Bloemen, Soile Blomqvist, Froukje Bosma, Sindy Böttcher, Laura Bubba, Stafan Buderus, Maria Cabrerizo, Christina Calvo, Christina Celma, Ferruccio Ceriotti, Gemma Clark, Inës Costa, Marianne Coste-Burel, Karen Couderé, Jeroen Cremer, Margarita Del Cuerpo Casas, Theo Daehne, Jessica de Beer, Maria de Ceano-Vivas, Cillian De Gascun, Alexis de Rougemont, Johnathan Dean, Jennifer L Dembinski, Sabine Diedrich, Javier Diez-Domingo, Lena Dillner, Dagny H Dorenberg, Alexandra Ducancelle, Susanne Dudman, Robert Dyrdak, Anna-Maria Eis-Huebinger, Iker Falces-Romero, Agnes Farkas, Susan Feeney, Maria D Fernandez-Garcia, Jacky Flipse, Kristina T Franck, Cristina Galli, Isabelle Garrigue, Felix Geeraedts, Irina Georgieva, Federica Giardina, Raquel Guiomar, Elenor Hauzenberger, Esther Heikens, Cécille Henquell, Didier Hober, Amrio Hönemann, Hannah Howson-Wells, Željka Hruškar, Niina Ikonen, Berthemarie Imbert, Arjan R Jansz, Marion Jeannoël, Helena Jiřincová, Laurence Josset, Kathrin Keeren, Naomie Kramer-Lindhout, Sidsel Krokstad, Mouna Lazrek, Hélène Le Guillou-Guillemette, Caroline Lefeuvre, Andreas Lind, Maja M Lunar, Melanie Maier, Stéphanie Marque-Juillet, C Patrick McClure, James McKenna, Adam Meijer, Ana Menasalvas Ruiz, Beatriz Mengual-Chuliá, Sofie Midgley, Audrey Mirand, Richard Molenkamp, Milagrosa Montes, Antonio Moreno-Docón, Ursula Morley, Jean-Luc Murk, Ana Navascués-Ortega, Roel Nijhuis, Lubomira Nikolaeva-Glomb, Svein A Nordbø, Sanela Numanovic, Massimo Oggioni, Eider Oñate Vergara, Jordi Pacaud, Marie L Pacreau, Marcus Panning, Elena Pariani, Lili Pekova, Laura Pellegrinelli, Miroslav Petrovec, Corinna Pietsch, Léa Pilorge, Luis Piñeiro, Antonio Piralla, Mario Poljak, Birgit Prochazka, Nuria Rabella, Janette C Rahamat-Langendoen, Petra Rainetova, Marijke Reynders, Annelies Riezebos-Brilman, Lieuwe Roorda, Carita Savolainen-Kopra, Isabelle Schuffenecker, Leo C Smeets, Ayse Stoyanova, Karl Stefic, Caroline Swanink, Irena Tabain, Jeroen Tjhie, Luc Thouault, Camille Tumiotto, Sara Uceda Renteria, Tina Uršič, Sophie Vallet, Marc Van Ranst, Peter Van Wunnik, Jaco J Verweij, Jorgina Vila, Bas Wintermans, Elke Wollants, Katja C Wolthers, F Xavier López-Labrado, Thea Kolsen Fischer, Heli Harvala, Kimberley S M Benschop
Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 and its clinical impact during the fall-winter season of 2021/22. From 19 European countries, 58 institutes reported 10,481 (6.8%) EV-positive samples of which 1,004 (9.6%) were identified as EV-D68 (852 respiratory samples). Clinical data was reported for 969 cases...
March 28, 2024: Journal of Infectious Diseases
#40
JOURNAL ARTICLE
Kata Farkas, Jessica L Kevill, Rachel C Williams, Igor Pântea, Nicola Ridding, Kathryn Lambert-Slosarska, Nick Woodhall, Jasmine M S Grimsley, Matthew J Wade, Andrew C Singer, Andrew J Weightman, Gareth Cross, Davey L Jones
Wastewater-based epidemiology is now widely used in many countries for the routine monitoring of SARS-CoV-2 and other viruses at a community level. However, efficient sample processing technologies are still under investigation. In this study, we compared the performance of the novel Nanotrap® Microbiome Particles (NMP) concentration method to the commonly used polyethylene glycol (PEG) precipitation method for concentrating viruses from wastewater and their subsequent quantification and sequencing. For this, we first spiked wastewater with SARS-CoV-2, influenza and measles viruses and norovirus and found that the NMP method recovered 0...
2024: FEMS Microbes
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