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https://www.readbyqxmd.com/read/29165766/clinical-analysis-of-59-children-with-hand-foot-and-mouth-diseases-due-to-enterovirus-ev71-and-concomitant-viral-encephalitis
#1
M-G Wang, H-M Sun, X-M Liu, X-Q Deng
OBJECTIVE: To analyzed the clinical features of children with HFMD and viral encephalitis and to summarize some treatments. PATIENTS AND METHODS: A total of 59 children with HFMD were included in this study. All children underwent complete blood count, blood biochemical test cerebrospinal fluid examination, chest X-ray and brain MRI. RESULTS: One child died 24 hours after admission due to central respiratory failure with myocardial damage...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29165333/pressure-for-pattern-specific-intertypic-recombination-between-sabin-polioviruses-evolutionary-implications
#2
Ekaterina Korotkova, Majid Laassri, Tatiana Zagorodnyaya, Svetlana Petrovskaya, Elvira Rodionova, Elena Cherkasova, Anatoly Gmyl, Olga E Ivanova, Tatyana P Eremeeva, Galina Y Lipskaya, Vadim I Agol, Konstantin Chumakov
Complete genomic sequences of a non-redundant set of 70 recombinants between three serotypes of attenuated Sabin polioviruses as well as location (based on partial sequencing) of crossover sites of 28 additional recombinants were determined and compared with the previously published data. It is demonstrated that the genomes of Sabin viruses contain distinct strain-specific segments that are eliminated by recombination. The presumed low fitness of these segments could be linked to mutations acquired upon derivation of the vaccine strains and/or may have been present in wild-type parents of Sabin viruses...
November 22, 2017: Viruses
https://www.readbyqxmd.com/read/29162476/prevention-and-treatment-of-respiratory-viral-infections-presentations-on-antivirals-traditional-therapies-and-host-directed-interventions-at-the-5th-isirv-antiviral-group-conference
#3
Jennifer L McKimm-Breschkin, Shibo Jiang, David S Hui, John H Beigel, Elena A Govorkova, Nelson Lee
The International Society for Influenza and other Respiratory Virus Diseases held its 5th Antiviral Group (isirv-AVG) Conference in Shanghai, China, in conjunction with the Shanghai Public Health Center and Fudan University from 14-16 June, 2017. The three-day programme encompassed presentations on some of the clinical features, management, immune responses and virology of respiratory infections, including influenza A(H1N1)pdm09 and A(H7N9) viruses, MERS-CoV, SARS-CoV, adenovirus Type 80, enterovirus D68, metapneumovirus and respiratory syncytial virus (RSV)...
November 18, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29162204/surveillance-and-laboratory-detection-for-non-polio-enteroviruses-in-the-european-union-european-economic-area-2016
#4
Heli Harvala, Aftab Jasir, Pasi Penttinen, Lucia Pastore Celentano, Donato Greco, Eeva Broberg
Enteroviruses (EVs) cause severe outbreaks of respiratory and neurological disease as illustrated by EV-D68 and EV-A71 outbreaks, respectively. We have mapped European laboratory capacity for identification and characterisation of non-polio EVs to improve preparedness to respond to (re)-emerging EVs linked to severe disease. An online questionnaire on non-polio EV surveillance and laboratory detection was submitted to all 30 European Union (EU)/European Economic Area (EEA) countries. Twenty-nine countries responded; 26 conducted laboratory-based non-polio EV surveillance, and 24 included neurological infections in their surveillance...
November 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29158047/-fatal-case-of-enterovirus-a71%C3%A2-hand-foot-and-mouth-disease-infection
#5
V Corvest, C Archimbaud, A-S L'Honneur, C Henquell, H Peigue-Lafeuille, M Decobert, A Mirand
Hand, foot, and mouth disease associated with enterovirus (EV) infections is a common pediatric pathology that is usually considered as benign. However, neurological complications of varying severity, sometimes fatal, are possible, particularly when EV-A71 is involved. Several Asian countries are regularly affected by large-scale epidemics of EV infections with substantial morbidity and mortality, where early screening and appropriate therapeutic management are a public health challenge. In 2016, Europe experienced an epidemic of unusual magnitude, associated with increasing cases of severe neurological complications in Spain and France, mainly affecting children...
November 17, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29156632/neurotropism-in-vitro-and-mouse-models-of-severe-and-mild-infection-with-clinical-strains-of-enterovirus-71
#6
Pin Yu, Linlin Bao, Lili Xu, Fengdi Li, Qi Lv, Wei Deng, Yanfeng Xu, Chuan Qin
Enterovirus 71 (EV71) is a common etiological agent of hand, foot, and mouth disease and fatal neurological diseases in children. The neuropathogenicity of severe EV71 infection has been documented, but studies comparing mouse models of severe and mild EV71 infection are lacking. The aim of the study was to investigate the neurovirulence of EV71 strains and the differences in serum cytokine and chemokine levels in mouse models of severe and mild EV71 infection. Nine EV71 isolates belonging to the C4 subgenogroup (proposed as genotype D) displayed infectivity in human neuroblastoma SK-N-SH cells; moreover, ultrastructural observation confirmed viral particle replication...
November 20, 2017: Viruses
https://www.readbyqxmd.com/read/29153065/-genotypes-of-rhinoviruses-in-children-and-adults-patients-with-acute-respiratory-tract-infections
#7
Eda Demirkan, Sevin Kırdar, Emel Ceylan, Ayşe Yenigün, İmran Kurt Ömürlü
Rhinovirus (RV) is one of the most frequent causative agent of acute respiratory tract infections in the world. The virus may cause a mild cold, as well as more serious clinical symptoms in patients with immune system deficiency or comorbidities. Rhinoviruses have been identified by molecular methods under three types: RV-A, RV-B and RV-C. In most of the cases, it was reported that RV-A and RV-C were related with lower respiratory tract infections and asthma exacerbations, while RV-B was rarely reported in lower respiratory tract infections...
October 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29151123/a-coxsackievirus-b-vaccine-protects-against-virus-induced-diabetes-in-an-experimental-mouse-model-of-type-1-diabetes
#8
Virginia M Stone, Minna M Hankaniemi, Emma Svedin, Amirbabak Sioofy-Khojine, Sami Oikarinen, Heikki Hyöty, Olli H Laitinen, Vesa P Hytönen, Malin Flodström-Tullberg
AIMS/HYPOTHESIS: Epidemiological studies suggest a role for Coxsackievirus B (CVB) serotypes in the pathogenesis of type 1 diabetes, but their actual contribution remains elusive. In the present study, we have produced a CVB1 vaccine to test whether vaccination against CVBs can prevent virus-induced diabetes in an experimental model. METHODS: NOD and SOCS1-tg mice were vaccinated three times with either a formalin-fixed non-adjuvanted CVB1 vaccine or a buffer control...
November 18, 2017: Diabetologia
https://www.readbyqxmd.com/read/29147125/comparison-of-the-prevalence-of-enteroviruses-in-blood-samples-of-patients-with-and-without-unstable-angina
#9
Aida Gholoobi, Zahra Meshkat, Akram Baghani, Maryam Sadat Alavi, Toktam Mohammadpoor, Mastoureh Momen-Heravi, Mohsen Mouhebati, Samaneh Sepahi, Sina Rostami, Mojtaba Meshkat, Arash Gholoobi
BACKGROUND: Although the role of enteroviruses has been proved in heart diseases, extensive information is not available on the association between enteroviruses and unstable angina. In the present study, the authors compared the prevalence of enteroviruses in patients with and without unstable angina. METHODS: Blood samples were taken from 51 patients with unstable angina and 55 patients without unstable angina or myocardial infarction that were admitted to Imam Reza and Ghaem hospitals (Mashhad, northeast of Iran)...
July 2017: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/29134337/recombination-analysis-of-coxsackievirus-b5-genogroup-c
#10
Hongxing Shen
Coxsackievirus B5 (CVB5) is a member of the species Enterovirus B of the genus Enterovirus, family Picornaviridae. Based on its VP1 sequence, CVB5 is divided into four genogroups: A, B, C, and D. From 2002 to 2012, CVB5 serotype genogroup C caused an outbreak of aseptic meningitis in China. In order to study the evolution of CVB5 genogroup C, phylogenetic and recombination analysis was performed using the 399 available enterovirus B genome sequences in the GenBank database. The results indicated that 10 strains of CVB5 serotype genogroup C resulted from recombination between members of genogroup B and echovirus serotype E6, and another 5 strains resulted from recombination between members of genogroup C and serotype CVB4...
November 13, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29129453/hepatitis-b-virus-core-particles-containing-multiple-epitopes-confer-protection-against-enterovirus-71-and-coxsackievirus-a16-infection-in-mice
#11
Chunling Huo, Jie Yang, Lei Lei, Lei Qiao, Jiantao Xin, Zishu Pan
Human enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are the two major causative agents of hand-foot-and-mouth disease (HFMD). To investigate novel combined vaccines to prevent EV71 and CA16 infection, we constructed chimeric virus-like particles (tHBc/SPA or tHBc/SP VLPs) displaying conserved epitopes of EV71 (aa 208-222 of VP1 and aa 248-263 of VP2) and CA16 (aa271-285 of VP1) using a truncated hepatitis B virus core carrier (tHBc). Immunization with the chimeric VLPs induced epitope- or virus-specific IgG and neutralization antibodies against EV71 and CA16 in the mice...
November 9, 2017: Vaccine
https://www.readbyqxmd.com/read/29127186/formyl-peptide-receptor-2-is-regulated-by-rna-mimics-and-viruses-through-an-ifn-%C3%AE-stat3-dependent-pathway
#12
Patrick B Ampomah, Leonardo A Moraes, Hakim M Lukman, Lina H K Lim
The regulation of host factors is a key strategy employed by viruses to suppress host defense systems and enhance their propagation; however, the mechanisms that underlie this regulation is still unclear. Formyl peptide receptor 2 (FPR2) recognizes numerous proinflammatory and anti-inflammatory stimuli, and emerging reports indicate elevated levels of FPR2 in several disease conditions. Although studies have implicated FPR2 in a myriad of inflammatory conditions, how viruses exploit this cell-surface receptor to facilitate disease progression remains unknown...
November 10, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29122098/contribution-of-3cd-region-to-the-virulence-of-enterovirus-71
#13
Jing Li, Feng Gao, Shu Bin Hao, Dong Cheng, Wen Qiang Zhang, Bin Lin, Li Zhao, Xue Jie Yu, Zhi Yu Wang, Hong Ling Wen
Enterovirus 71 is a neuroinvasive virus that is associated with severe neurological complications. We had earlier suggested that the replication capacity of a severe strain was higher than that of a mild strain. The recombinant 3CRV and 3CDRV virus strains were successfully rescued in our previous study. In the present study, we found no difference in virulence between 3CRV and severe strains. However, the capacity of replication and to cause cell injury of 3CDRV strain decreased in vitro, especially at 39...
October 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29122092/rapid-and-accurate-sequencing-of-enterovirus-genomes-using-minion-nanopore-sequencer
#14
Ji Wang, Yue Hua Ke, Yong Zhang, Ke Qiang Huang, Lei Wang, Xin Xin Shen, Xiao Ping Dong, Wen Bo Xu, Xue Jun Ma
OBJECTIVE: Knowledge of an enterovirus genome sequence is very important in epidemiological investigation to identify transmission patterns and ascertain the extent of an outbreak. The MinION sequencer is increasingly used to sequence various viral pathogens in many clinical situations because of its long reads, portability, real-time accessibility of sequenced data, and very low initial costs. However, information is lacking on MinION sequencing of enterovirus genomes. METHODS: In this proof-of-concept study using Enterovirus 71 (EV71) and Coxsackievirus A16 (CA16) strains as examples, we established an amplicon-based whole genome sequencing method using MinION...
October 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29120300/enterovirus-71-antagonizes-the-antiviral-activity-of-host-stat3-and-il-6r-with-partial-dependence-on-virus-induced-mir-124
#15
Zhangmei Chang, Yan Wang, Liang Bian, Qingqing Liu, Jian-Er Long
Enterovirus 71 (EV71) has caused major outbreaks of hand, foot and mouth disease. EV71 infections increase the production of many host cytokines and pro-inflammatory factors, including interleukin (IL)-6, IL-10 and COX-2. Some of these molecules could stimulate the signal transducer and activator of transcription 3 (STAT3), which plays a key role in regulating host immune responses and several viral diseases. However, the role of STAT3 in EV71 infection remains unknown. This study found that the phosphorylation levels of STAT3 (p(Y705)-STAT3) are closely related to EV71 infection...
November 9, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/29119851/clinical-characteristics-of-children-infected-with-enterovirus-d68-in-an-outpatient-clinic-and-the-association-with-bronchial-asthma
#16
Tsutomu Itagaki, Yoko Aoki, Yohei Matoba, Shizuka Tanaka, Tatsuya Ikeda, Katsumi Mizuta, Yoko Matsuzaki
BACKGROUND: All reports of increases in severe respiratory disease associated with human enterovirus D68 (EV-D68) are from hospital settings. However, there are few reports describing clinical characteristics in less severely affected populations. METHODS: We conducted a retrospective observational study from January 2010 to December 2015 in Yamagata, Japan. Using regional passive surveillance, 5794 respiratory specimens were collected from children who initially presented to an outpatient clinic with acute respiratory symptoms...
November 9, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/29119244/enterovirus-associated-changes-in-blood-transcriptomic-profiles-of-children-with-genetic-susceptibility-to-type-1-diabetes
#17
Niina Lietzen, Le T T An, Maria K Jaakkola, Henna Kallionpää, Sami Oikarinen, Juha Mykkänen, Mikael Knip, Riitta Veijola, Jorma Ilonen, Jorma Toppari, Heikki Hyöty, Riitta Lahesmaa, Laura L Elo
AIMS/HYPOTHESIS: Enterovirus infections have been associated with the development of type 1 diabetes in multiple studies, but little is known about enterovirus-induced responses in children at risk for developing type 1 diabetes. Our aim was to use genome-wide transcriptomics data to characterise enterovirus-associated changes in whole-blood samples from children with genetic susceptibility to type 1 diabetes. METHODS: Longitudinal whole-blood samples (356 samples in total) collected from 28 pairs of children at increased risk for developing type 1 diabetes were screened for the presence of enterovirus RNA...
November 8, 2017: Diabetologia
https://www.readbyqxmd.com/read/29116763/interaction-of-human-enteric-viruses-with-microbial-compounds-implication-for-virus-persistence-and-disinfection-treatments
#18
Prunelle Waldman, Alba Meseguer, Françoise Lucas, Laurent Moulin, Sébastien Wurtzer
Although the interaction between phages and bacteria has already been well described, it only recently emerged that human viruses also interact with bacteria in the mammalian gut. We studied whether this interaction could occur in tap water and thus confer enteric viruses protection against temperature and the classical disinfection treatments used in drinking water production. We demonstrated that the addition of lipopolysaccharide or peptidoglycan of bacterial origin to enterovirus provides thermal protection through stabilization of the viral capsid...
November 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29116409/chronic-meningoencephalitis-caused-by-echo-virus%C3%A2-6-in-a%C3%A2-patient-with-common-variable-immunodeficiency-successful-treatment-with-pleconaril
#19
Igor Radanović, Deni Rkman, Paulo Zekan, Marko Kutleša, Bruno Baršić
Chronic enteroviral meningoencephalitis, most commonly caused by echoviruses, can particularly be seen in agammaglobulinemic patients. In spite of the fact that no specific treatment for enteroviral infections exists, pleconaril is an antiviral drug reported to be efficient against enteroviral infections in infants and adults. We present a case of a 42-year-old male, previously diagnosed with common variable immunodeficiency, who presented with severe chronic meningoencephalitis caused by Echo virus 6 and was successfully treated with pleconaril...
November 7, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/29115952/no-evidence-of-enteric-viral-involvement-in-the-new-neonatal-porcine-diarrhoea-syndrome-in-danish-pigs
#20
N B Goecke, C K Hjulsager, H Kongsted, M Boye, S Rasmussen, F Granberg, T K Fischer, S E Midgley, L D Rasmussen, Ø Angen, J P Nielsen, S E Jorsal, L E Larsen
BACKGROUND: The aim of this study was to investigate whether the syndrome New Neonatal Porcine Diarrhoea Syndrome (NNPDS) is associated with a viral aetiology. Four well-managed herds experiencing neonatal diarrhoea and suspected to be affected by NNPDS were included in a case-control set up. A total of 989 piglets were clinically examined on a daily basis. Samples from diarrhoeic and non-diarrhoeic piglets at the age of three to seven days were selected for extensive virological examination using specific real time polymerase chain reactions (qPCRs) and general virus detection methods...
November 7, 2017: BMC Veterinary Research
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