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https://www.readbyqxmd.com/read/27914475/an-observational-study-of-febrile-seizures-the-importance-of-viral-infection-and-immunization
#1
Joshua R Francis, Peter Richmond, Christine Robins, Katie Lindsay, Avram Levy, Paul V Effler, Meredith Borland, Christopher C Blyth
BACKGROUND: Febrile seizures are common in young children. Annual peaks in incidence mirror increased respiratory virus activity during winter. Limited virological data are available using modern diagnostic techniques for children with febrile seizures. We aimed to determine the frequency of detection of specific viral pathogens in children with febrile seizures, to describe risk factors including recent vaccination and clinical features associated with specific etiologies. METHODS: An observational study was performed...
December 3, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27914285/human-parechovirus-and-enterovirus-initiate-distinct-cns-innate-immune-responses-pathogenic-and-diagnostic-implications
#2
Danielle Fortuna, Ana María Cárdenas, Erin H Graf, Larry A Harshyne, D Craig Hooper, Michael Prosniak, John Shields, Mark T Curtis
BACKGROUND: Human parechovirus (HPeV) and enterovirus (EV) cause a range of human diseases including serious CNS infections. Little is known regarding the immune response to HPeV meningitis compared to EV meningitis or how the immune response to HPeV reflects its pathogenesis. OBJECTIVE: To characterize the innate immune response to HPeV CNS infection in order to increase our understanding of HPeV pathogenesis and possibly help identify HPeV in the clinical setting...
November 23, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27909105/enterovirus-infections
#3
Asif Noor, Leonard R Krilov
No abstract text is available yet for this article.
December 2016: Pediatrics in Review
https://www.readbyqxmd.com/read/27907970/-epidemiology-etiology-and-clinical-picture-of-enteroviral-meningitis-in-children-in-south-moravia
#4
Adriana Braunová, Petra Rainetová, Lenka Krbková, Iva Čapovová, Lenka Klapačová, Václav Musil, Martin Musílek, Jana Bednářová
OBJECTIVES: Enteroviruses (EVs) are the most common cause of aseptic viral meningitis. In some cases, they can cause severe meningoencephalitis and acute flaccid paralysis - an association with some virulent serotypes. The objectives were to describe the epidemiological situation of EV meningitis in children in South Moravia, to elucidate the etiology including the incidence of virulent serotypes and to evaluate the clinical presentation. MATERIAL AND METHODS: A total of 88 children with EV meningitis were prospectively evaluated...
September 2016: Klinická Mikrobiologie a Infekc̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27907198/a-molecular-approach-applied-to-enteroviruses-surveillance-in-northern-taiwan-2008-2012
#5
Wan-Yu Chung, Pai-Shan Chiang, Shu-Ting Luo, Tzou-Yien Lin, Kuo-Chien Tsao, Min-Shi Lee
Traditional methods for detection and serotyping of enterovirus infections are virus isolation and immunofluorescence assay (VI-IFA), which are labor-intensive and time-consuming. Recently, VP1 gene has been targeted to develop a CODEHOP-based RT-PCR (VP1-CODEHOP) for the same purpose. In this study, we conducted a 5-year enterovirus surveillance comparing the VI-IFA and VP1-CODEHOP tests. Throat swabs were collected from 431 pediatric patients and 208(48%) and 250(58%) were tested positive by the VI-IFA and VP1-CODEHOP tests, respectively...
2016: PloS One
https://www.readbyqxmd.com/read/27905343/unilateral-hemorrhagic-maculopathy-an-uncommon-manifestation-of-hand-foot-and-mouth-disease
#6
Manish Tandon, Abhishek Gupta, Priyanka Singh, Gnanavelu N Subathra
Hand, foot, and mouth disease (HFD) is a common systemic infection occurring in childhood or immunocompromised adults caused by enteroviruses, the most common being coxsackievirus A16 and enterovirus 71. It is characterized by maculopapular eruptions over the hands and feet and ulcerative stomatitis. Ocular involvement is a rare complication and commonly manifests as inflammatory macular pathology. We report a case of HFD in an immunocompetent adult male with unilateral ocular involvement presenting as hemorrhagic maculopathy and its management with complete anatomical and functional recovery...
October 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27902407/genomic-characterization-of-two-new-enterovirus-types-ev-a114-and-ev-a121
#7
Jagadish M Deshpande, Deepa K Sharma, Vinay K Saxena, Sushmitha A Shetty, Tarique Husain Ih Qureshi, Uma P Nalavade
Enteroviruses cause a variety of illnesses of the gastrointestinal tract, central nervous system as well as cardiovascular system. Phylogenetic analysis of VP1 sequences has identified 106 different human enteroviruses classified into four enterovirus species within genus Enterovirus of the Picornaviridae family. It is likely that not all enterovirus types have been discovered. Between September 2013 and October 2014, stool samples of 6274 apparently healthy children up to 5 years of age residing in Gorakhpur district, Uttar Pradesh, India were screened for enteroviruses...
October 28, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27902385/motor-coordination-and-balance-measurements-reveal-differential-pathogenicity-of-currently-spreading-ev71-strains-in-human-scarb2-transgenic-mice
#8
Mei-Feng Chen, Shin-Ru Shih
Enterovirus 71 (EV71) has caused large-scale epidemics with neurological complications in Asia Pacific region. The C4a and B5 strains are the two major genotypes circulalted in many coutries recently. This study provides a new protocol, a motor coordination task, to assess the differential pathogenicity of C4a and B5 strains in human SCARB2 transgenic mice. We found that the pathogenicity of C4a viruses was more severe than that of B5 viruses. Moreover, we discovered that an increased level of monocyte chemoattractant protein-1 is positively correlated with severely deficient motor function...
October 20, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27902359/determinants-of-the-vp1-2a-junction-cleavage-by-the-3c-protease-in-foot-and-mouth-disease-virus-infected-cells
#9
Thea Kristensen, Preben Normann, Maria Gullberg, Ulrik Fahnøe, Charlotta Polacek, Thomas Bruun Rasmussen, Graham J Belsham
The foot-and-mouth disease virus (FMDV) capsid precursor, P1-2A, is cleaved by FMDV 3C protease to yield VP0, VP3, VP1 and 2A. Cleavage of the VP1/2A junction is the slowest. Serotype O FMDVs with uncleaved VP1-2A (having a K210E substitution in VP1; at position P2 in cleavage site) have been described previously and acquired a second site substitution (VP1 E83K) during virus rescue. Furthermore, introduction of the VP1 E83K substitution alone generated a second site change at the VP1/2A junction (2A L2P, position P2' in cleavage site)...
November 18, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27901633/acute-flaccid-paralysis-laboratorial-surveillance-in-a-polio-free-country-brazil-2005-2014
#10
Ivanildo P Sousa, Fernanda M Burlandy, Silas S Oliveira, Amanda M Nunes, Cristiane Sousa, Elaine M da Silva, Jaqueline G A Souza, Valdemar A de Paula, Ivone C M Oliveira, Fernando Neto Tavares, Eliane V da Costa, Edson E da Silva
The last case of paralytic poliomyelitis caused by wild poliovirus in Brazil occurred in 1989. The interruption of the indigenous poliovirus transmission was obtained through mass immunization campaigns to eligible children and an active epidemiological and laboratorial surveillance of all cases of acute flaccid paralysis (AFP) among children under fifteen years of age. This paper describes and evaluates the performance of the AFP surveillance system in different geographic areas of Brazil between 2005 and 2014, using indicators recommended by WHO...
November 30, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27899653/control-of-the-negative-ires-trans-acting-factor-khsrp-by-ubiquitination
#11
Yu-An Kung, Chuan-Tien Hung, Kun-Yi Chien, Shin-Ru Shih
Cells and viruses can utilize internal ribosome entry sites (IRES) to drive translation when cap-dependent translation is inhibited by stress or viral factors. IRES trans-acting factors (ITAFs) are known to participate in such cap-independent translation, but there are gaps in the understanding as to how ITAFs, particularly negative ITAFs, regulate IRES-driven translation. This study found that Lys109, Lys121 and Lys122 represent critical ubiquitination sites for far upstream element-binding protein 2 (KHSRP, also known as KH-type splicing regulatory protein or FBP2), a negative ITAF...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27898715/hand-foot-and-mouth-disease-in-hunan-province-china-2009-2014-epidemiology-and-death-risk-factors
#12
Kai-Wei Luo, Li-Dong Gao, Shi-Xiong Hu, Hong Zhang, Zhi-Hong Deng, Wei Huang, Qian-Lai Sun, Fan Zhang, Si-Yu Zhang, Yu Chen
Hand, foot, and mouth disease (HFMD) is an arising public health problem in Asia, including China. Epidemiological data is necessary to enable judicious public health responses and interventions. We analyzed the epidemiological and laboratory data of 759,301 HFMD cases reported to the Hunan Provincial Center for Disease Control and Prevention from 1 January 2009 to 31 December 2014. Univariate and multivariable conditional logistic regression analyses were used to identify risk factors of fatality in HFMD. The incidence of HFMD was highest among children aged 1-3 years, compared with other age groups...
2016: PloS One
https://www.readbyqxmd.com/read/27898578/risk-classification-for-enteroviral-infection-in-children-with-meningitis-and-negative-gram-stain
#13
Ramia Zakhour, Elizabeth Aguilera, Rodrigo Hasbun, Susan H Wootton
OBJECTIVES: Enterovirus is the most common cause of aseptic meningitis in children. This study aimed at identifying baseline variables associated with a positive cerebrospinal fluid (CSF) Enterovirus polymerase chain reaction (PCR) to aid clinicians in targeting patients who could be tested and treated as outpatients. METHODS: We performed a retrospective review of children (2 months to 17 years old) admitted to the Children's Memorial Hermann Hospital in Houston, TX, between January 2005 and December 2010 with symptoms of meningitis, CSF white cell count of greater than 5 cells/mm, and a negative CSF Gram stain, who had a CSF Enterovirus PCR...
November 24, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27894305/identification-of-molecular-determinants-of-cell-culture-growth-characteristics-of-enterovirus-71
#14
Pinn Tsin Isabel Yee, Kuan Onn Tan, Iekhsan Othman, Chit Laa Poh
BACKGROUND: Hand, foot and mouth disease is caused by Enterovirus 71 (EV-A71) and Coxsackieviruses. EV-A71 infection is associated with high fever, rashes and ulcers but more severe symptoms such as cardiopulmonary failure and death have been reported. The lack of vaccines highlighted the urgency of developing preventive agents against EV-A71. The molecular determinants of virulent phenotypes of EV-A71 is unclear. It remains to be investigated if specific molecular determinants would affect the cell culture growth characteristics of the EV-A71 fatal strain in Rhabdomyosarcoma (RD) cells...
November 28, 2016: Virology Journal
https://www.readbyqxmd.com/read/27893696/molecular-epidemiological-study-of-enteroviruses-associated-with-encephalitis-in-children-from-hangzhou-china
#15
Wei Li, Zhang Qiong, Shen Xiao-Ting, Liu Yu-Jie, Mao Jian-Hua, Shu Qiang, Shang Shi-Qiang
Enterovirus (EV) has over 100 serotypes of species A-D, which can cause various symptoms in infants. Enterovirus encephalitis (EVE) is serve disease with high morbidity and mortality in children. To well define the epidemiology of EVE, we wanted to know more about EV and EV molecular typing by conducting this study in Hangzhou.Cerebrospinal fluid samples were collected from children with diagnosis of encephalitis. Meanwhile, one-step real-time RT-PCR was used for the detection of EV, and we also identified the serotypes of EV by using gene sequencing of VP1 or 5'UTR region...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27890633/comparison-analysis-of-micrornas-in-response-to-ev71-and-ca16-infection-in-human-bronchial-epithelial-cells-by-high-throughput-sequencing-to-reveal-differential-infective-mechanisms
#16
Yajie Hu, Jie Song, Longding Liu, Jing Li, Beibei Tang, Ying Zhang, Jingjing Wang, Lichun Wang, Shengtao Fan, Ming Feng, Qihan Li
Hand, foot, and mouth disease (HFMD) mainly caused by Enterovirus 71 (EV71) and coxsackievirus A16 (CA16) infections which presented significantly different clinical manifestations. Nevertheless, the factors underlying these differences remain unclear. Recently, the functions of microRNAs (miRNAs) in pathogen-host interactions have been highlighted. Here, we performed comprehensive miRNA profiling in EV71- and CA16-infected human bronchial epithelial (16HBE) cells at multiple time points using high-throughput sequencing...
November 24, 2016: Virus Research
https://www.readbyqxmd.com/read/27888461/inhibitory-effects-of-bee-venom-and-its-components-against-viruses-in-vitro-and-in-vivo
#17
Md Bashir Uddin, Byeong-Hoon Lee, Chamilani Nikapitiya, Jae-Hoon Kim, Tae-Hwan Kim, Hyun-Cheol Lee, Choul Goo Kim, Jong-Soo Lee, Chul-Joong Kim
Bee venom (BV) from honey bee (Apis Melifera L.) contains at least 18 pharmacologically active components including melittin (MLT), phospholipase A2 (PLA2), and apamin etc. BV is safe for human treatments dose dependently and proven to possess different healing properties including antibacterial and antiparasitidal properties. Nevertheless, antiviral properties of BV have not well investigated. Hence, we identified the potential antiviral properties of BV and its component against a broad panel of viruses. Co-incubation of non-cytotoxic amounts of BV and MLT, the main component of BV, significantly inhibited the replication of enveloped viruses such as Influenza A virus (PR8), Vesicular Stomatitis Virus (VSV), Respiratory Syncytial Virus (RSV), and Herpes Simplex Virus (HSV)...
December 2016: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/27880820/from-lab-to-lake-evaluation-of-current-molecular-methods-for-the-detection-of-infectious-enteric-viruses-in-complex-water-matrices-in-an-urban-area
#18
Mats Leifels, Ibrahim Ahmed Hamza, Marion Krieger, Michael Wilhelm, Martin Mackowiak, Lars Jurzik
Quantitative PCR methods are commonly used to monitor enteric viruses in the aquatic environment because of their high sensitivity, short reaction times and relatively low operational cost. However, conclusions for public health drawn from results of such molecular techniques are limited due to their inability to determine viral infectivity. Ethidium monoazide (EMA) and propidium monoazide (PMA) are capable to penetrate the damaged or compromised capsid of the inactivated viruses and bind to the viral nucleic acids...
2016: PloS One
https://www.readbyqxmd.com/read/27878462/enterovirus-a71-and-coxsackievirus-a16-show-different-replication-kinetics-in-human-neuronal-and-non-neuronal-cell-lines
#19
Thinesshwary Yogarajah, Kien Chai Ong, David Perera, Kum Thong Wong
Enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16) are closely related enteroviruses that cause hand, foot and mouth disease (HFMD) in children. Serious neurological complications almost always occur in EV-A71 infection, but are rare in CV-A16 infection. Based on the hypothesis that this may be because EV-A71 infects neuronal cells more easily than CV-A16, we compared virus infection, replication and spread of EV-A71 and CV-A16 in SK-N-SH cells. We found that CV-A16 invariably showed significantly lower replication and caused less necrotic cell death in SK-N-SH cells, compared with EV-A71...
November 23, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27875780/vp1-residues-around-the-five-fold-axis-of-enterovirus-a71-mediate-heparan-sulfate-interaction
#20
Chee Wah Tan, I-Ching Sam, Vannajan Sanghiran Lee, Hui Vern Wong, Yoke Fun Chan
Enterovirus A71 (EV-A71) is a neurotropic enterovirus that uses heparan sulfate as an attachment receptor. The molecular determinants of EV-A71-heparan sulfate interaction are unknown. With In silico heparin docking and mutagenesis of all possible lysine residues in VP1, we identified that K162, K242 and K244 are responsible for heparin interaction and inhibition. EV-A71 mutants with K242A and K244A rapidly acquired compensatory mutations, T100K or E98A, and Q145R-T237N respectively, which restored the heparin-binding phenotype...
November 19, 2016: Virology
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