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https://www.readbyqxmd.com/read/29030378/worsening-guillain-barr%C3%A3-syndrome-harbinger-of-iris-in-hiv
#1
Neeharika L Mathukumalli, Niloufer Ali, Meena A Kanikannan, Sireesha Yareeda
We report an HIV patient aged 38 years with acute inflammatory demyelinating polyradiculoneuropathy subtype of Guillain-Barré syndrome (GBS) as the only manifestation of seroconversion and worsening of GBS being the harbinger of immune reconstitution inflammatory syndrome (IRIS). To date, only 5 cases of GBS during IRIS are reported. They manifested either during the third week or later after starting highly active antiretroviral therapy (HAART). Our patient witnessed worsening weakness by fifth day after starting HAART, even before the occurrence of Pneumocystis jirovecii pneumonia, cautioning one of the impending serious complications of IRIS and helped us initiate steroids at an early date...
October 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29028962/clinical-features-of-acute-flaccid-myelitis-temporally-associated-with-an-enterovirus-d68-outbreak-results-of-a-nationwide-survey-of-acute-flaccid-paralysis-in-japan-august-december-2015
#2
Pin Fee Chong, Ryutaro Kira, Harushi Mori, Akihisa Okumura, Hiroyuki Torisu, Sawa Yasumoto, Hiroyuki Shimizu, Tsuguto Fujimoto, Nozomu Hanaoka, Susumu Kusunoki, Toshiyuki Takahashi, Kazunori Oishi, Keiko Tanaka-Taya
Backgroud: Acute flaccid myelitis (AFM) is an acute flaccid paralysis (AFP) syndrome with spinal motor neuron involvement of unknown etiology. We investigated the characteristics and prognostic factors of AFM clusters coincident with an enterovirus D68 (EV-D68) outbreak in Japan during autumn 2015. Methods: An AFM case series study was conducted following a nationwide survey from August to December 2015. Radiographic and neurophysiologic data were subjected to centralized review, and virology studies were conducted for available specimens...
October 6, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29028178/zika-virus-immune-evasion-mechanisms-currently-available-therapeutic-regimens-and-vaccines
#3
Arun Asif, Sobia Manzoor, Fatima Tuz-Zahra, Muhammad Saalim, Maliha Ashraf, Javeria Ishtiyaq, Madiha Khalid
The sudden emergence of infectious pathogens such as Zika virus (ZIKV) holds global health concerns. Recent dissemination of ZIKV from Pacific to Americas with an upsurge of congenital anomalies and Guillain Barre Syndrome (GBS) in adults has created an alarming situation. High-throughput studies are in progress to understand ZIKV's mode of pathogenesis and mechanism of immune escape, yet the pathogenesis remains obscure. Mainly ZIKV's envelope (E) protein and nonstructural proteins (mainly NS1 and NS5) manipulate host cell to support viral immune escape by modulation of the interferon pathway and complement antagonism...
October 13, 2017: Viral Immunology
https://www.readbyqxmd.com/read/29027940/zika-virus-persistently-and-productively-infects-primary-adult-sensory-neurons-in-vitro
#4
Brianna K Swartwout, Marta G Zlotnick, Ashley E Saver, Caroline M McKenna, Andrea S Bertke
Zika virus (ZIKV) has recently surged in human populations, causing an increase in congenital and Guillain-Barré syndromes. While sexual transmission and presence of ZIKV in urine, semen, vaginal secretions, and saliva have been established, the origin of persistent virus shedding into biological secretions is not clear. Using a primary adult murine neuronal culture model, we have determined that ZIKV persistently and productively infects sensory neurons of the trigeminal and dorsal root ganglia, which innervate glands and mucosa of the face and the genitourinary tract, respectively, without apparent injury...
October 13, 2017: Pathogens
https://www.readbyqxmd.com/read/29026634/hiv-positive-patient-with-gbs-like-syndrome
#5
Samantha J Shepherd, Heather Black, Emma C Thomson, Rory N Gunson
Introduction. Guillain-Barré Syndrome (GBS) is an acute demyelinating polyneuropathy which can occur post-infection. Criteria of diagnosis of GBS include areflexia with progressive bilateral weakness in arms and legs. GBS can lead to severe respiratory and cardiac complications. The fatality rate can be up to 5 % in patients, depending on the severity of the symptoms. HIV can cause a range of neurological disorders including, on rare occasions, GBS. GBS can occur at any stage of HIV infection, highlighting the complexity of diagnosis of GBS within HIV patients...
August 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29026553/gitelman-syndrome-a-rare-life-threatening-case-of-hypokalemic-paralysis-mimicking-guillain-barr%C3%A3-syndrome-during-pregnancy-and-review-of-the-literature
#6
Abdelghafour Elkoundi, Noureddine Kartite, Mustapha Bensghir, Nawfal Doghmi, Salim Jaafar Lalaoui
In rare cases, patients with Gitelman syndrome may present with hypokalemic paralysis mimicking Guillain-Barré syndrome. The severity of resultant symptoms may be life-threatening. Controversial drugs such as aldactone, amiloride, and eplerenone should be used in this situation despite the lack of safety data.
October 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29024971/early-predictors-of-guillain-barr%C3%A3-syndrome-in-the-life-course-of-women
#7
Nathalie Auger, Caroline Quach, Jessica Healy-Profitós, Trish Dinh, Michaël Chassé
Background: We sought to determine if immune disorders early in life were associated with the later risk of Guillain-Barré syndrome, a neurological disorder thought to be infection-related. Methods: We conducted a longitudinal cohort study with 16 108 819 person-years of follow-up for a population of 1 108 541 parous women in Quebec, Canada (1989-2014). The outcome was Guillain-Barré syndrome. We identified women with potential risk factors for future Guillain-Barré syndrome, including immune-mediated and rheumatological diseases, cancer, transfusion, surgical procedures and pregnancy-specific disorders...
September 2, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29024023/chronic-active-epstein-barr-virus-infection-with-cutaneous-lymphoproliferation-haemophagocytosis-in-the-skin-and-haemophagocytic-syndrome
#8
S Tokoro, T Namiki, K Miura, K Watanabe, A Arai, K Imadome, H Yokozeki
Patients with chronic active Epstein-Barr virus (EBV) infections (CAEBV) present with cutaneous manifestations including hydroa vacciniforme-like eruptions.(1) Haemophagocytic lymphohistiocytosis (HLH), a fatal complication, can occur in severe cases of CAEBV.(2,3) We retrieved 25 cases of CAEBV treated in our hospital and histopathologically characterized the skin lesions of 3 of those cases, including one case with haemophagocytosis. This is a novel report of CAEBV with haemophagocytosis in the skin. This article is protected by copyright...
October 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29022866/ictv-virus-taxonomy-profile-hepeviridae
#9
Michael A Purdy, Tim J Harrison, S Jameel, X-J Meng, H Okamoto, W H M Van der Poel, Donald B Smith, Ictv Report Consortium
The family Hepeviridae includes enterically transmitted small non-enveloped positive-sense RNA viruses. It includes the genera Piscihepevirus, whose members infect fish, and Orthohepevirus, whose members infect mammals and birds. Members of the genus Orthohepevirus include hepatitis E virus, which is responsible for self-limiting acute hepatitis in humans and several mammalian species; the infection may become chronic in immunocompromised individuals. Extrahepatic manifestations of Guillain-Barré syndrome, neuralgic amyotrophy, glomerulonephritis and pancreatitis have been described in humans...
October 12, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/29022864/reverse-genetic-system-genetically-stable-reporter-viruses-and-packaged-subgenomic-replicon-based-on-a-brazilian-zika-virus-isolate
#10
Margit Mutso, Sirle Saul, Kai Rausalu, Olga Susova, Eva Žusinaite, Suresh Mahalingam, Andres Merits
Zika virus (ZIKV, genus Flavivirus) has emerged as a major mosquito-transmitted human pathogen, with recent outbreaks associated with an increased incidence of neurological complications, particularly microcephaly and the Guillain-Barré syndrome. Because the virus has only very recently emerged as an important pathogen, research is being hampered by a lack of reliable molecular tools. Here we report an infectious cDNA (icDNA) clone for ZIKV isolate BeH819015 from Brazil, which was selected as representative of South American ZIKV isolated at early stages of the outbreak...
October 12, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/29021960/relapsing-ebv-encephalitis-in-a-renal-transplant-recipient
#11
Joshua A Stone, Bettina M Knoll, Dimitrios Farmakiotis
In solid organ transplant recipients, Epstein-Barr virus (EBV) can cause active central nervous system (CNS) infection or malignant transformation of latently infected cells in the CNS, known as post-transplant lymphoproliferative disease (PTLD). Reduction of T-cell immunosuppression is the cornerstone of management. The role of antivirals with in-vitro activity against herpesviruses in EBV-related CNS syndromes is controversial, as they have no effect on latent virus. We report an unusual case of relapsing EBV encephalitis in a donor-positive, EBV-negative renal transplant recipient, with response to valganciclovir...
2017: IDCases
https://www.readbyqxmd.com/read/29020489/multiple-evanescent-white-dot-syndrome-following-acute-epstein-barr-virus-infection
#12
Chang-Sue Yang, Ming-Hung Hsieh, Huan-I Su, Yih-Shiuan Kuo
PURPOSE: To investigate the association between multiple evanescent white dot syndrome (MEWDS) and Epstein-Barr (EB) virus infection. METHODS: A prospective, consecutive case series study was performed in patients with the characteristic findings of MEWDS. Patients received EB viral-specific antibody serologic tests. RESULTS: Five cases of MEWDS who had prodromal flu-like symptoms were enrolled, comprising 2 women and 3 men with a mean age of 34...
October 11, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29020245/guillain-barr%C3%A3-syndrome-associated-with-zika-virus-infection-in-martinique-in-2016-a-prospective-study
#13
Benoît Rozé, Fatiha Najioullah, Jean-Louis Fergé, Frédérique Dorléans, Kossivi Apetse, Jose-Luis Barnay, Elise Daudens-Vaysse, Yannick Brouste, Raymond Césaire, Laurence Fagour, Ruddy Valentino, Martine Ledrans, Hossein Mehdaoui, Sylvie Abel, Isabelle Leparc-Goffart, Aissatou Signate, André Cabié
Background: Guillain-Barré syndrome (GBS) has been reported to be associated with Zika virus (ZIKV) infection in case reports and retrospective studies, mostly on the basis of serological tests, with the problematic cross-reacting antibodies of the Flavivirus genus. Some GBS cases do not exhibit a high level of diagnostic certainty. This prospective study aimed to describe the clinical profiles and the frequency of GBS associated with ZIKV during the ZIKV outbreak in Martinique in 2016...
July 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29017313/posttraumatic-guillain-barr%C3%A3-syndrome-immediately-following-a-traffic-accident
#14
Jungook Kim, Ho Yong Choi, Young Min Lee, Joon Soo Kim
Guillain-Barré syndrome (GBS) is an inflammatory demyelinating polyneuropathy characterized by areflexic paralysis. Most cases of GBS are preceded by an infection, however, posttraumatic GBS has also recently been reported. We report a case of posttraumatic GBS immediately following a traffic accident. We think this case is of clinical significance for practitioners because of the rare cause of a sudden flaccid paralysis following trauma.
September 2017: Korean Journal of Spine
https://www.readbyqxmd.com/read/28991722/risk-of-psychiatric-disorders-in-guillain-barre-syndrome-a-nationwide-population-based-cohort-study
#15
Nian-Sheng Tzeng, Hsin-An Chang, Chi-Hsiang Chung, Fu-Huang Lin, Chin-Bin Yeh, San-Yuan Huang, Chuan-Chia Chang, Ru-Band Lu, Yu-Chen Kao, Hui-Wen Yeh, Wei-Shan Chiang, Wu-Chien Chien
BACKGROUND: Guillain-Barre syndrome (GBS) is a rare immune-related neurological disorder with high mortality and morbidity, but the comorbid psychiatric disorders garnered little attention in the GBS patients. This study aimed to investigate the association between GBS and the risk of developing psychiatric disorders. METHODS: A total of 18,192 enrolled patients, with 4548 study subjects who had suffered GBS, and 13,644 controls matched for gender and age, from the Inpatient Dataset of 2000-2013 in Taiwan, and selected from the National Health Insurance Research Database (NHIRD)...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28991697/zika-virus-disease-associated-guillain-barr%C3%A3-syndrome-barranquilla-colombia-2015-2016
#16
Jorge L Salinas, Diana M Walteros, Ashley Styczynski, Flavio Garzón, Hernán Quijada, Elsa Bravo, Pablo Chaparro, Javier Madero, Jorge Acosta-Reyes, Jeremy Ledermann, Zuleima Arteta, Erin Borland, Paul Burns, Maritza Gonzalez, Ann M Powers, Marcela Mercado, Alma Solano, James J Sejvar, Martha L Ospina
BACKGROUND: An outbreak of Guillain-Barré syndrome (GBS), a disorder characterized by acute, symmetric limb weakness with decreased or absent deep-tendon reflexes, was reported in Barranquilla, Colombia, after the introduction of Zika virus in 2015. We reviewed clinical data for GBS cases in Barranquilla and performed a case-control investigation to assess the association of suspect and probable Zika virus disease with GBS. METHODS: We used the Brighton Collaboration Criteria to confirm reported GBS patients in Barranquilla during October 2015-April 2016...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28987189/diseases-of-the-peripheral-nerves
#17
Istvan Katona, Joachim Weis
This chapter reviews the diseases of the peripheral nerves from a neuropathologic point of view, with a special focus on specific morphologic changes, and includes a summary of the histopathologic methods available for their diagnosis. As the rate of obesity and the prevalence of type 2 diabetes increase, diabetic neuropathy is the most common cause of peripheral neuropathy. Many systemic disorders with metabolic origin, like amyloidosis, hepatic failure, vitamin deficiencies, uremia, lipid metabolism disorders, and others, can also cause axonal or myelin alterations in the peripheral nervous system...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28986470/quality-of-life-in-inflammatory-neuropathies-the-in-qol
#18
Thomas H P Draak, Catharina G Faber, Ingemar S J Merkies
BACKGROUND: No consensus exists which quality of life (QoL) measure should be used in patients with inflammatory neuropathies. Moreover, most QoL measures are ordinal-based scales with their known deficiencies. OBJECTIVES: To establish a new disease-specific interval-based QoL questionnaire in inflammatory neuropathies (IN-QoL) using the Rasch model and evaluate its scientific properties (validity, reliability and responsiveness). METHODS: 264 patients with inflammatory neuropathies completed six commonly used QoL questionnaires...
October 6, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28985957/pediatric-guillain-barr%C3%A3-syndrome-is-a-low-amplitude-of-nerve-action-potentials-always-a-bad-omen
#19
EDITORIAL
Wolfgang Müller-Felber
No abstract text is available yet for this article.
November 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28983187/viral-causes-of-lymphoma-the-history-of-epstein-barr-virus-and-human-t-lymphotropic-virus-1
#20
REVIEW
Daniel Esau
In 1964, Epstein, Barr, and Achong published a report outlining their discovery of viral particles in lymphoblasts isolated from a patient with Burkitt lymphoma. The Epstein-Barr virus (EBV) was the first human cancer virus to be described, and its discovery paved the way for further investigations into the oncogenic potential of viruses. In the decades following the discovery of EBV, multinational research efforts led to the discovery of further viral causes of various human cancers. Lymphomas are perhaps the cancer type that is most closely associated with oncogenic viruses: infection with EBV, human T-lymphotropic virus 1 (HTLV-1), human immunodeficiency virus (HIV), Kaposi sarcoma-associated herpesvirus/human herpesvirus 8, and hepatitis C virus have all been associated with lymphomagenesis...
2017: Virology: Research and Treatment
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