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https://www.readbyqxmd.com/read/27888720/postmortem-serum-levels-of-ige-and-mast-cell-tryptase-in-fatal-asthma
#1
Maria Pia Scarpelli, Sanjiv Keller, Lara Tran, Cristian Palmiere
The aim of this study was to characterize the concentrations of total and specific IgE as well as mast cell-derived tryptase in postmortem serum from femoral blood and evaluate the usefulness of their determination for diagnostic purposes in cases of fatal asthma attacks. 36 autopsy cases were retrospectively selected including cases of witnessed death in asthmatic subjects, deaths in asthmatics and atopic subjects with causes of death unrelated to asthma or allergic anaphylaxis as well as deaths in non-atopic, non-allergic individuals with causes of death unrelated to asthma or allergic anaphylaxis...
December 2016: Forensic Science International
https://www.readbyqxmd.com/read/27870665/near-fatal-asthma-a-heterogeneous-clinical-entity
#2
José Serrano-Pariente, Vicente Plaza
PURPOSE OF REVIEW: The aims of the present review were to describe the heterogeneous nature of near-fatal asthma (NFA) and to summarize the distinctive phenotypes identified in this subtype of asthma. RECENT FINDINGS: Clinical, physiological, and histological studies have shown a large number of triggers, pathological mechanisms, and risk factors associated with NFA. Based on the demographic and clinical characteristics of the patients, the circumstances surrounding the asthma exacerbation and some distinctive features of the disease, several clinical profiles of asthma patients with NFA have been described...
November 18, 2016: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27815425/stat6-regulates-the-development-of-eosinophilic-versus-neutrophilic-asthma-in-response-to-alternaria-alternata
#3
Andrea C Valladao, Charles W Frevert, Lisa K Koch, Daniel J Campbell, Steven F Ziegler
Human asthma is a heterogeneous disease characterized by the expression of both Th2 and Th17 cytokines. In vitro and in vivo studies have shown a reciprocal regulation between Th2 and Th17 pathways, suggesting a potential induction of neutrophil-promoting Th17 inflammation in the absence of a Th2 response. Alternaria alternata is a clinically relevant allergen that is associated with severe and fatal asthma exacerbations. Exposure to A. alternata is characterized by a predominant Th2 response, but can also induce the production of factors associated with Th17 responses (e...
December 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27788885/comparison-of-systemic-reactions-in-rush-cluster-and-standard-build-aeroallergen-immunotherapy
#4
Andrew W Winslow, Joseph C Turbyville, J Wesley Sublett, James L Sublett, Stephen J Pollard
BACKGROUND: Given the choice of standard, cluster, and rush build-up for aeroallergen immunotherapy, standard-build immunotherapy has generally been preferred because of a perceived high rate of systemic reactions (SRs) associated with cluster and rush immunotherapy. OBJECTIVE: To characterize the incidence of SRs during standard, cluster, and rush build-up immunotherapy in an allergy practice during a 5-year period. METHODS: A retrospective review was conducted among patients receiving standard-build, 8- to 10-step cluster, or 2-day rush immunotherapy from January 1, 2010, through December 31, 2014, at Family Allergy & Asthma clinics in Louisville, Kentucky...
November 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27775253/the-non-communicable-disease-burden-in-korea-findings-from-the-2012-korean-burden-of-disease-study
#5
Jihyun Yoon, Hyeyoung Seo, In Hwan Oh, Seok Jun Yoon
In recognition of Korea's rising burden of non-communicable diseases (NCDs), we investigated the nation's NCD status and extracted detailed information from the 2012 Korean Burden of Disease study. Consistent with that study, we used disability-adjusted life year (DALY) as a metric. Using national data sources and disability weights specific to the Korean population, we analyzed 116 disaggregated NCDs from the study's four-level disease and injury hierarchy for both sexes and nine age groups. Per 100,000 population, 21,019 DALYs were lost to 116 NCDs...
November 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27758969/extracorporeal-membrane-oxygenation-support-for-life-threatening-acute-severe-status-asthmaticus
#6
Gabriella Di Lascio, Edvin Prifti, Elmi Messai, Adriano Peris, Guy Harmelin, Roland Xhaxho, Albana Fico, Guido Sani, Massimo Bonacchi
INTRODUCTION: Status asthmaticus is a life-threatening condition characterized by progressive respiratory failure due to asthma that is unresponsive to standard therapeutic measures. We used extracorporeal membrane oxygenation (ECMO) to treat patients with near-fatal status asthamticus who did not respond to aggressive medical therapies and mechanical ventilation under controlled permissive hypercapnia. MATERIALS AND METHODS: Between January 2011 and October 2015, we treated 16 adult patients with status asthmaticus (8 women, 8 men, mean age: 50...
October 6, 2016: Perfusion
https://www.readbyqxmd.com/read/27752310/asthma-related-deaths
#7
Gennaro D'Amato, Carolina Vitale, Antonio Molino, Anna Stanziola, Alessandro Sanduzzi, Alessandro Vatrella, Mauro Mormile, Maurizia Lanza, Giovanna Calabrese, Leonardo Antonicelli, Maria D'Amato
Despite major advances in the treatment of asthma and the development of several asthma guidelines, people still die of asthma currently. According to WHO estimates, approximately 250,000 people die prematurely each year from asthma. Trends of asthma mortality rates vary very widely across countries, age and ethnic groups. Several risk factors have been associated with asthma mortality, including a history of near-fatal asthma requiring intubation and mechanical ventilation, hospitalization or emergency care visit for asthma in the past year, currently using or having recently stopped using oral corticosteroids (a marker of event severity), not currently using inhaled corticosteroids, a history of psychiatric disease or psychosocial problems, poor adherence with asthma medications and/or poor adherence with (or lack of) a written asthma action plan, food allergy in a patient with asthma...
2016: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/27737429/reply-to-contemporary-treatment-of-children-with-critical-and-near-fatal-asthma
#8
Steven L Shein, Richard H Speicher, Alexandre T Rotta
No abstract text is available yet for this article.
September 2016: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/27737422/to-contemporary-treatment-of-children-with-critical-and-near-fatal-asthma
#9
José Colleti Junior, Werther Brunow de Carvalho
No abstract text is available yet for this article.
September 2016: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/27595415/vitamin-d-for-the-management-of-asthma
#10
Adrian R Martineau, Christopher J Cates, Mitsuyoshi Urashima, Megan Jensen, Alex P Griffiths, Ulugbek Nurmatov, Aziz Sheikh, Chris J Griffiths
BACKGROUND: Several clinical trials of vitamin D to prevent asthma exacerbation and improve asthma control have been conducted in children and adults, but a meta-analysis restricted to double-blind, randomised, placebo-controlled trials of this intervention is lacking. OBJECTIVES: To evaluate the efficacy of administration of vitamin D and its hydroxylated metabolites in reducing the risk of severe asthma exacerbations (defined as those requiring treatment with systemic corticosteroids) and improving asthma symptom control...
September 5, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27555875/potential-factors-involved-in-the-causation-of-rhabdomyolysis-following-status-asthmaticus
#11
REVIEW
Hongmei Qiao, Huanji Cheng, Li Liu, Jianing Yin
Rhabdomyolysis is a rare but potentially fatal complication of status asthmaticus. Since the first case was reported in 1978, only a few dozen cases have been described till date. We performed a literature review with the aim to characterize the pathophysiological basis of the occurrence of rhabdomyolysis in patients with status asthmaticus. Excessive exertion of respiratory muscles, hypoxia and acidosis, electrolyte imbalance, infections, some drugs used for asthma control, use of mechanical ventilation, prolonged cardiopulmonary resuscitation, higher age of the patient and some underlying diseases or genetic factors appear to be involved in its causation...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27554811/acute-asthma-prognosis-and-treatment
#12
Jennifer E Fergeson, Shiven S Patel, Richard F Lockey
Asthma affects about 300 million people globally and accounts for 1 in every 250 deaths in the world. Approximately 12 million people in the United States each year experience an acute exacerbation of their asthma, a quarter of which require hospitalization. Acute asthma should be differentiated from poor asthma control. Patients with acute asthma will exhibit increasing shortness of breath, chest tightness, coughing, and/or wheezing. In contrast, poor asthma control typically presents with a diurnal variability in airflow and is a characteristic that is usually not seen during an acute exacerbation...
August 20, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27553829/interventional-lung-assist-and-extracorporeal-membrane-oxygenation-in-a-patient-with-near-fatal-asthma
#13
Seok Jeong Lee, Yong Sung Cha, Chun Sung Byun, Sang-Ha Kim, Myoung Kyu Lee, Suk Joong Yong, Won-Yeon Lee
No abstract text is available yet for this article.
August 2, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27553751/long-term-efficacy-and-safety-of-mepolizumab-in-patients-with-severe-eosinophilic-asthma-a-multi-center-open-label-phase-iiib-study
#14
Njira Lugogo, Christian Domingo, Pascal Chanez, Richard Leigh, Martyn J Gilson, Robert G Price, Steven W Yancey, Hector G Ortega
PURPOSE: Patients with severe eosinophilic asthma often experience recurrent asthma exacerbations despite intensive inhaled corticosteroid therapy. In 2 previous double-blind studies (MENSA [NCT01691521] and SIRIUS [NCT01691508]), treatment with intravenous or subcutaneous mepolizumab was associated with significantly reduced annualized exacerbation rates and oral corticosteroid (OCS) requirements compared with placebo. The purpose of this study was to assess the long-term safety and efficacy of subcutaneous mepolizumab treatment in patients with severe eosinophilic asthma...
September 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27487784/epidemiology-of-invasive-pneumococcal-infections-manifestations-incidence-and-case-fatality-rate-correlated-to-age-gender-and-risk-factors
#15
Erik Backhaus, Stefan Berg, Rune Andersson, Gunilla Ockborn, Petter Malmström, Mats Dahl, Salmir Nasic, Birger Trollfors
BACKGROUND: Incidence, manifestations and case-fatality rate (CFR) of invasive pneumococcal disease (IPD) vary with age and comorbidities. New vaccines, changing age distribution, prolonged survival among immunocompromised patients and improved sepsis management have created a need for an update of basic facts to inform vaccine recommendations. METHODS: Age, gender and comorbidities were related to manifestations and death for 2977 consecutive patients with IPD in a Swedish region with 1...
August 3, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27425166/near-fatal-asthma-treatment-and-prevention
#16
REVIEW
G D'Amato, C Vitale, M Lanza, A Sanduzzi, A Molino, M Mormile, A Vatrella, M B Bilò, L Antonicelli, M Bresciani, C Micheletto, A Vaghi, M D'Amato
Near-fatal asthma (NFA) is described as acute asthma associated with a respiratory arrest or arterial carbon dioxide tension greater than 50 mmHg, with or without altered consciousness, requiring mechanical ventilation. Risk factors for near fatal asthma have not been fully elucidated. In 80-85% of all fatal events, a phenotype, characterized by eosinophilic inflammation associated with gradual deterioration occurring in patients with severe and poorly controlled asthma, has been identified. Regarding to the management, acute severe asthma remains a significant clinical problem, which needs to be identified to facilitate early and appropriate therapeutic interventions...
July 2016: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27408644/common-causes-of-dyspnoea-in%C3%A2-athletes-a-practical-approach-for-diagnosis-and-management
#17
James M Smoliga, Zahra S Mohseni, Jeffrey D Berwager, Eric J Hegedus
KEY POINTS: "Dyspnoea" during exercise is a common complaint in seemingly otherwise healthy athletes, which may be associated with fatigue and underperformance.Because dyspnoea is an general term and may be caused by numerous factors, ranging from poor aerobic fitness to serious, potentially fatal respiratory and nonrespiratory pathologies, it is important for clinicians to obtain an appropriate case history and ask relevant exercise-specific questions to fully characterise the nature of the complaint so that a targeted diagnostic plan can be developed...
June 2016: Breathe
https://www.readbyqxmd.com/read/27371733/glucocorticoid-and-tnf-signaling-converge-at-a20-tnfaip3-to-repress-airway-smooth-muscle-cytokine-expression
#18
Sarah K Sasse, Mohammed O Altonsy, Vineela Kadiyala, Gaoyuan Cao, Reynold A Panettieri, Anthony N Gerber
Airway smooth muscle is a major target tissue for glucocorticoid (GC)-based asthma therapies, however, molecular mechanisms through which the GC receptor (GR) exerts therapeutic effects in this key airway cell type have not been fully elucidated. We previously identified the nuclear factor-κB (NF-κB) inhibitor, A20 (TNFAIP3), as a mediator of cytokine repression by glucocorticoids (GCs) in airway epithelial cells and defined cooperative regulation of anti-inflammatory genes by GR and NF-κB as a key mechanistic underpinning of airway epithelial GR function...
August 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27368034/short-term-starvation-with-a-near-fatal-asthma-attack-induced-ketoacidosis-in-a-nondiabetic-pregnant-woman-a-case-report
#19
Kuang-Yu Wei, Shan-Yueh Chang, Sheng-Huei Wang, Her-Young Su, Chen-Liang Tsai
Life-threatening refractory metabolic acidosis due to starvation ketoacidosis is rarely reported, even among nondiabetic pregnant women, and may be overlooked. Furthermore, stressful situations may increase the acidosis severity.In the present case, a nondiabetic multiparous woman was admitted for a near-fatal asthma attack and vomiting during the third trimester of pregnancy. She was intubated and rapidly developed high anion gap metabolic acidosis. We diagnosed the patient with starvation ketoacidosis based on vomiting with concomitant periods of stress during pregnancy and the absence of other causes of high anion gap metabolic acidosis...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27359239/-anesthetic-management-in-bronchial-asthma
#20
Alf Kozian, Thomas Schilling, Thomas Hachenberg
In daily practice, acute and chronic pulmonary diseases are common issues presenting to the anesthetist. Respiratory physiology in general is affected by both general and regional anesthesia, which results in an increased number of perioperative complications in pulmonary risk patients. Therefore, anesthetic management of patients with bronchial asthma needs to address different clinical topics: the physical appearance of pulmonary disease, type and extent of surgical intervention as well as effects of therapeutic drugs, anesthetics and mechanical ventilation on respiratory function...
June 2016: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
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