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https://www.readbyqxmd.com/read/28938790/factors-affecting-adipose-tissue-development-in-chickens-a-review
#1
Guoqing Wang, Woo Kyun Kim, Mark A Cline, Elizabeth R Gilbert
The intense genetic selection for rapid growth in broilers has resulted in an increase in voluntary feed intake and growth rate, accompanied by increased fat deposition in adipose tissue depots throughout the body. Adipose tissue expansion is a result of the formation of adipocytes (several processes collectively referred to as adipogenesis) and cellular accumulation of triacylglycerols inside lipid droplets. In mammals, different anatomical depots are metabolically distinct. The molecular and cellular mechanisms underlying adipose tissue development have been characterized in mammalian models, whereas information in avian species is scarce...
October 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28938518/antimicrobial-peptides-amps-the-quintessential-offense-and-defense-molecules-are-more-than-antimicrobials
#2
REVIEW
Seema Patel, Nadeem Akhtar
Antimicrobial peptides (AMPs) are cationic amphiphilic molecules with α-helix or β-sheet linear motifs and linear or cyclic configurations. For their role in 'defense and offense', they are present in all living organisms. AMPs are named so, as they inhibit a wide array of microbes by membrane pore formation and subsequent perturbation of mitochondrial membrane ionic balance. However, their functional repertoire is expanding with validated roles in cytotoxicity, wound healing, angiogenesis, apoptosis, and chemotaxis [1]...
September 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28938491/inhibition-of-fgfr-signaling-partially-rescues-hypophosphatemic-rickets-in-hmwfgf2-tg-male-mice
#3
Liping Xiao, Erxia Du, Collin Homer-Bouthiette, Marja M Hurley
Transgenic mice harboring high molecular weight FGF2 isoforms (HMWTg) in osteoblast lineage cells phenocopy human X-linked hypophosphatemic rickets (XLH) and Hyp murine model of XLH demonstrating increased FGF23/FGF receptor signaling and hypophosphatemic rickets. Since HMWFGF2 was upregulated in bones of Hyp mice and abnormal FGF receptor (FGFR) signaling is important in XLH, HMWTg mice were used to examine the effect of the FGFR inhibitor NVP-BGJ398, now in clinical trials for cancer therapy, on hypophosphatemic rickets...
August 14, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938459/selective-glucocorticoid-receptor-antagonist-cort125281-activates-brown-adipose-tissue-and-alters-lipid-distribution-in-male-mice
#4
Jan Kroon, Lisa L Koorneef, Jose K van den Heuvel, Cristy R C Verzijl, Nienke M van de Velde, Isabel M Mol, Hetty C M Sips, Hazel Hunt, Patrick C N Rensen, Onno C Meijer
Glucocorticoids influence a wide range of metabolic processes in the human body and excessive glucocorticoid exposure is known to contribute to the development of metabolic disease. We evaluated the utility of the novel glucocorticoid receptor (GR) antagonist CORT125281 for its potential to overcome adiposity, glucose intolerance and dyslipidaemia, and compared this head-to-head with classic GR antagonist RU486 (mifepristone). We show that, while RU486 displays cross-reactivity to the progesterone and androgen receptor, CORT125281 selectively inhibits GR transcriptional activity...
September 18, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938451/antibody-mediated-targeting-of-the-fgfr1c-isoform-increases-glucose-uptake-in-white-and-brown-adipose-tissue-in-male-mice
#5
Jo E Lewis, Ricardo J Samms, Scott Cooper, Jeni C Luckett, Alan C Perkins, James D Dunbar, Dennis P Smith, Paul J Emmerson, Andrew C Adams, Francis J P Ebling, Kostas Tsintzas
The increased prevalence of obesity and its cardiometabolic implications demonstrates the imperative to identify novel therapeutic targets able to effect meaningful metabolic changes in this population. Antibody-mediated targeting of fibroblast growth factor receptor 1c isoform (FGFR1c) has been shown to ameliorate hyperglycaemia and protect from diet- and genetically-induced obesity in rodents and non-human primates. However, it is currently unknown which tissue(s) contribute to this glucose lowering effect...
August 16, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938003/oxsa-an-open-source-magnetic-resonance-spectroscopy-analysis-toolbox-in-matlab
#6
Lucian A B Purvis, William T Clarke, Luca Biasiolli, Ladislav Valkovič, Matthew D Robson, Christopher T Rodgers
In vivo magnetic resonance spectroscopy provides insight into metabolism in the human body. New acquisition protocols are often proposed to improve the quality or efficiency of data collection. Processing pipelines must also be developed to use these data optimally. Current fitting software is either targeted at general spectroscopy fitting, or for specific protocols. We therefore introduce the MATLAB-based OXford Spectroscopy Analysis (OXSA) toolbox to allow researchers to rapidly develop their own customised processing pipelines...
2017: PloS One
https://www.readbyqxmd.com/read/28937980/methanobrevibacter-attenuation-via-probiotic-intervention-reduces-flatulence-in-adult-human-a-non-randomised-paired-design-clinical-trial-of-efficacy
#7
Minseok Seo, Jaeyoung Heo, Joon Yoon, Se-Young Kim, Yoon-Mo Kang, Jihyun Yu, Seoae Cho, Heebal Kim
TRIAL DESIGN: The aim of this study was to investigate which of the gut microbes respond to probiotic intervention, as well as study whether they are associated with gastrointestinal symptoms in a healthy adult human. For the experimental purpose, twenty-one healthy adults were recruited and received probiotic mixture, which is composed of five Lactobacilli strains and two Bifidobacteria strains, once a day for 60 days. Defecation survey and Bioelectrical Impedance Analysis were conducted pre- and post-administration to measure phenotypic differences...
2017: PloS One
https://www.readbyqxmd.com/read/28937733/surface-engineering-of-graphene-composite-transparent-electrodes-for-high-performance-flexible-triboelectric-nanogenerators-and-self-powered-sensors
#8
Jun Yang, Peibo Liu, Xingzhan Wei, Wei Luo, Jin Yang, Hao Jiang, Dapeng Wei, Ruiying Shi, Haofei Shi
A high performance transparent and flexible triboelectric nanogenerator (TENG) based on graphene composite electrodes via surface engineering is proposed and demonstrated. Through modifying the CVD-grown graphene by conductive polymer poly(3,4-ethylenedioxy-thiophene):polystyrenesulfonate (PEDOT:PSS), the composite electrodes with excellent optoelectronic performances were fabricated, which exhibited a high transmittance up to 85% and sheet resistance of 85 Ω/□ decreasing from the initial value of 725 Ω/□...
September 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28937221/in-vivo-dissolution-and-systemic-absorption-of-immediate-release-ibuprofen-in-human-gastrointestinal-tract-under-fed-and-fasted-conditions
#9
Duxin Sun, Jason R Baker, Bo Wen, Ann Frances, Huixia Zhang, Alex Yu, Ting Zhao, Yasuhiro Tsume, Manjunath Pai, Barry Bleske, Xinyuan Zhang, R Lionberger, Allen Lee, Gordon Amidon, William L Hasler, Mark Koenigsknecht
PURPOSE: In vivo drug dissolution in the gastrointestinal (GI) tract is largely unmeasured. The purpose of this clinical study was to evaluate the in vivo drug dissolution and systemic absorption of the BCS Class IIa drug ibuprofen under fed and fasted conditions by direct sampling of stomach and small intestinal luminal content. Expanding current knowledge of drug dissolution in vivo will help to establish physiologically relevant in vitro models predictive of drug dissolution. METHODS: A multi-lumen GI catheter was orally inserted into the GI tract of healthy human subjects...
September 22, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28937004/suicide-in-india-part-perceptions-partial-insights-and-inadequate-solutions
#10
K S Jacob
Suicide is a complex phenomenon, often linked to environment. Despite the identification of many social, cultural, economic and political correlates and risk factors, psychiatry continues to argue for curative solutions based on the reductionistic biomedical model, rather than support public health measures to manage the larger sociocultural, economic and political context. While psychiatry and curative medicine help many people, survival of the human body is best explained by the materialist explanation that locates the variation in health and longevity to tangible resources...
May 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/28936609/a-hierarchical-testing-strategy-for-micropollutants-in-drinking-water-regarding-their-potential-endocrine-disrupting-effects-towards-health-related-indicator-values
#11
Jochen Kuckelkorn, Regine Redelstein, Timon Heide, Jennifer Kunze, Sibylle Maletz, Petra Waldmann, Tamara Grummt, Thomas-Benjamin Seiler, Henner Hollert
In Germany, micropollutants that (may) occur in drinking water are assessed by means of the health-related indicator value (HRIV concept), developed by the German Federal Environment Agency. This concept offers five threshold values (≤ 0.01 to ≤ 3 μg l(-1)) depending on availability and completeness of data regarding genotoxicity, neurotoxicity, and germ cell-damaging potential. However, the HRIV concept is yet lacking integration of endocrine disruptors as one of the most prominent toxicological concerns in water bodies, including drinking water...
September 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28936585/understanding-intestinal-glucose-transporter-expression-in-obese-compared-to-non-obese-subjects
#12
Rebecca A Deal, Yueming Tang, Reid Fletcher, Alfonso Torquati, Philip Omotosho
INTRODUCTION: The impact of Roux-en-Y gastric bypass (RYGB) on weight loss and co-morbid disease resolution is well established. However, the mechanisms underlying the procedure remain incompletely understood. Intestinal remodeling involving glucose transporters (GLUTs) may play a crucial role. Rat studies have demonstrated morphological adaptation of GLUTs within adipose and intestinal cells in association with the reprogramming of glucose metabolism. There is a limited understanding of the variations in expression amongst GLUT family receptors in the human intestine...
September 21, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28936425/gut-dysbiosis-in-animals-due-to-environmental-chemical-exposures
#13
REVIEW
Cheryl S Rosenfeld
The gut microbiome consists of over 10(3)-10(4) microorganism inhabitants that together possess 150 times more genes that the human genome and thus should be considered an "organ" in of itself. Such communities of bacteria are in dynamic flux and susceptible to changes in host environment and body condition. In turn, gut microbiome disturbances can affect health status of the host. Gut dysbiosis might result in obesity, diabetes, gastrointestinal, immunological, and neurobehavioral disorders. Such host diseases can originate due to shifts in microbiota favoring more pathogenic species that produce various virulence factors, such as lipopolysaccharide...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28935835/total-body-pet-maximizing-sensitivity-to-create-new-opportunities-for-clinical-research-and-patient-care
#14
Simon R Cherry, Terry Jones, Joel S Karp, Jinyi Qi, William Moses, Ramsey Badawi
Positron emission tomography (PET) is widely considered as the most sensitive technique available for non-invasively studying physiology, metabolism and molecular pathways in the living human being. However, the utility of PET, being a photon deficient modality, remains constrained by factors including low signal-to-noise ratio (SNR), long imaging times and concerns regarding radiation dose. Two developments offer the potential to dramatically increase the effective sensitivity of PET. First by increasing the geometric coverage to encompass the entire body, sensitivity can be increased by a factor of ~40 for total-body imaging or a factor of ~4-5 for imaging a single organ such as the brain or heart...
September 21, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28935828/daily-resistance-type-exercise-stimulates-overall-muscle-protein-synthesis-rates-in-vivo-in-young-males
#15
Andrew M Holwerda, Kevin J M Paulussen, Maarten Overkamp, Joey S J Smeets, Annemie P Gijsen, Joy P B Goessens, Lex B Verdijk, Luc J C van Loon
BACKGROUND: Resistance-type exercise increases muscle protein synthesis rates during acute post-exercise recovery. The impact of resistance-type exercise training on (local) muscle protein synthesis rates under free living conditions on a day-to-day basis remains unclear. OBJECTIVE: To determine the impact of daily unilateral resistance-type exercise on local myofibrillar protein synthesis rates during a three-day period. METHODS: Twelve healthy young males (22±1 y) were recruited to participate in this study where they performed daily, unilateral resistance-type exercise during a three-day intervention period...
September 21, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28935631/cultural-crossings-of-care-an-appeal-to-the-medical-humanities
#16
Julia Kristeva, Marie Rose Moro, John Ødemark, Eivind Engebretsen
Modern medicine is confronted with cultural crossings in various forms. In facing these challenges, it is not enough to simply increase our insight into the cultural dimensions of health and well-being. We must, more radically, question the conventional distinction between the 'objectivity of science' and the 'subjectivity of culture'. This obligation creates an urgent call for the medical humanities but also for a fundamental rethinking of their grounding assumptions.Julia Kristeva (JK) has problematised the biomedical concept of health through her reading of the anthropogony of Cura (Care), who according to the Roman myth created man out of a piece of clay...
September 21, 2017: Medical Humanities
https://www.readbyqxmd.com/read/28935588/effect-of-methapyrilene-hydrochloride-on-hepatic-intracellular-iron-metabolism-in-vivo-and-in-vitro
#17
Iryna Kindrat, Kostiantyn Dreval, Svitlana Shpyleva, Volodymyr Tryndyak, Aline de Conti, Thilak K Mudalige, Tao Chen, Anna M Erstenyuk, Frederick A Beland, Igor P Pogribny
The liver, a central detoxification organ and main regulator of systemic iron homeostasis, is prone to damage by xenobiotics. In the present study, we investigated the effect of the hepatotoxicant and hepatocarcinogen methapyrilene hydrochloride on iron metabolism in rat liver in a repeat-dose in vivo toxicity study and in human HepaRG cells in vitro. Treatment of male Fischer 344 (F344) rats with methapyrilene at doses 40 and 80mg/kg body weight (bw)/day by gavage for 6 weeks resulted in changes in the expression of classic hepatotoxicity-related marker genes and iron homeostasis-related genes, especially a prominent, dose-dependent down-regulation of the transferrin (Tf) gene and an up-regulation of the ferritin, light chain (Ftl) gene...
September 18, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28935212/the-value-of-anticoccidials-for-sustainable-global-poultry-production
#18
REVIEW
Stefanie Kadykalo, Tara Roberts, Michelle Thompson, Jeff Wilson, Marcelo Lang, Olivier Espeisse
Coccidiosis is a self-limiting disease that is universally present in poultry operations, causing extensive damage to the intestinal lining of the bird. Global economic losses from coccidiosis are estimated to be $3 billion per year. In-feed anticoccidial use has been the predominant form of coccidiosis control. However, due to widespread emergence of antimicrobial resistance, concerns have been raised regarding the safety of anticoccidials and potential impact on human, animal, and environmental health. To investigate the alternatives, risks, and benefits to anticoccidial use, a comprehensive review of recent literature was conducted...
September 18, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28935141/antioxidative-peptide-from-milk-exhibits-antiosteopenic-effects-through-inhibition-of-oxidative-damage-and-bone-resorbing-cytokines-in-ovariectomized-rats
#19
Sanusi Bello Mada, Srinu Reddi, Naveen Kumar, Rohit Kumar, Suman Kapila, Rajeev Kapila, Ritu Trivedi, Anirudha Karvande, Naseer Ahmad
OBJECTIVES: Oxidative stress has been implicated as a crucial pathogenic factor in the development of postmenopausal osteoporosis. Milk-derived antioxidative peptides are gaining much attention toward the development of prodrugs for alleviating several human diseases, including osteoporosis. The aim of the present study was to determine whether antioxidant peptides are good candidates for alleviating postmenopausal osteoporosis. METHODS: In the present study, an ovariectomized (OVX) osteoporotic rat model was used to investigate the protective effects of buffalo milk casein-derived novel peptide VLPVPQK (PEP) against OVX-induced bone loss and the related mechanisms...
November 2017: Nutrition
https://www.readbyqxmd.com/read/28935140/d-allulose-enhances-postprandial-fat-oxidation-in-healthy-humans
#20
Tomonori Kimura, Akane Kanasaki, Noriko Hayashi, Takako Yamada, Tetsuo Iida, Yasuo Nagata, Kazuhiro Okuma
OBJECTIVE: d-Allulose, a C-3 epimer of d-fructose, has been reported to decrease body weight and adipose tissue weight in animal studies and is expected to be a potent antiobese sweetener. Our animal study suggested that one of the mechanisms of d-allulose's antiobesity function is an increase in energy expenditure. However, a few studies have thus far explored the underlying mechanism in humans. The aim of this study was to examine the effects of a single ingestion of d-allulose on postprandial energy metabolism in healthy participants...
November 2017: Nutrition
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