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https://www.readbyqxmd.com/read/29439286/evidence-flowers-an-innovative-visual-method-of-presenting-best-evidence-summaries-to-health-professional-and-lay-audiences
#1
O O Babatunde, V Tan, J L Jordan, K Dziedzic, C A Chew-Graham, C Jinks, J Protheroe, D A van der Windt
BACKGROUND & AIMS: Barriers to dissemination and engagement with evidence pose a threat to implementing evidence-based medicine. Understanding, retention and recall can be enhanced by visual presentation of information. The aim of this exploratory research was to develop and evaluate the accessibility and acceptability of visual summaries for presenting evidence syntheses with multiple exposures or outcomes to professional and lay audiences. METHODS: 'Evidence flowers' were developed as a visual method of presenting data from four case scenarios: two complex evidence syntheses with multiple outcomes, Cochrane reviews and clinical guidelines...
February 13, 2018: Research Synthesis Methods
https://www.readbyqxmd.com/read/29438656/postoperative-radiotherapy-for-oral-squamous-cell-carcinoma-with-histologic-risk-factors-are-we-over-treating
#2
REVIEW
Timothy Liu, Benjamin Chua, Martin Batstone
PURPOSE: The role of postoperative radiotherapy (PORT) remains controversial for patients with low-risk oral squamous cell carcinoma (OSCC) and adverse histologic features. The aim of this study was to examine the survival benefits in the role of PORT, when compared with surgery alone, among these patients. MATERIALS AND METHODS: In this systematic review, relevant published literature was identified in the PubMed database and eligible studies were included. Predictor variables were perineural invasion (PNI), lymphovascular invasion, and unfavorable grade...
January 31, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29437910/modern-diagnosis-of-gerd-the-lyon-consensus
#3
REVIEW
C Prakash Gyawali, Peter J Kahrilas, Edoardo Savarino, Frank Zerbib, Francois Mion, André J P M Smout, Michael Vaezi, Daniel Sifrim, Mark R Fox, Marcelo F Vela, Radu Tutuian, Jan Tack, Albert J Bredenoord, John Pandolfino, Sabine Roman
Clinical history, questionnaire data and response to antisecretory therapy are insufficient to make a conclusive diagnosis of GERD in isolation, but are of value in determining need for further investigation. Conclusive evidence for reflux on oesophageal testing include advanced grade erosive oesophagitis (LA grades C and D), long-segment Barrett's mucosa or peptic strictures on endoscopy or distal oesophageal acid exposure time (AET) >6% on ambulatory pH or pH-impedance monitoring. A normal endoscopy does not exclude GERD, but provides supportive evidence refuting GERD in conjunction with distal AET <4% and <40 reflux episodes on pH-impedance monitoring off proton pump inhibitors...
February 3, 2018: Gut
https://www.readbyqxmd.com/read/29436292/is-it-a-match-a-novel-method-of-evaluating-medical-school-success
#4
Leslie L Chang, Alisa Nagler, Mariah Rudd, Colleen O'Connor Grochowski, Edward G Buckley, Saumil M Chudgar, Deborah L Engle
BACKGROUND: Medical education program evaluation allows for curricular improvements to both Undergraduate (UME) and Graduate Medical Education (GME). UME programs are left with little more than match rates and self-report to evaluate success of graduates in The Match. OBJECTIVE: This manuscript shares a novel method of program evaluation through a systematic assessment of Match outcomes. DESIGN: Surveys were developed and distributed to Program Training Directors (PTDs) at our institution to classify residency programs into which our UME graduates matched using an ordinal response scale and open-ended responses...
December 2018: Medical Education Online
https://www.readbyqxmd.com/read/29435294/therapy-associated-myelodysplastic-syndrome-with-monosomy-7-arising-in-a-muir-torre-syndrome-patient-carrying-setbp1-mutation
#5
David Ullman, Erin Baumgartner, Nicholas Wnukowski, Gabe Koenig, Fady M Mikhail, Peter Pavlidakey, Deniz Peker
Muir-Torre Syndrome (MTS) is a rare hereditary autosomal dominant cancer syndrome and is linked to hereditary non-polyposis colorectal carcinoma (Lynch Syndrome). Individuals develop various skin neoplasms in addition to colorectal, endometrial and upper gastrointestinal malignancies. Therapy-associated myelodysplastic syndrome (T-MDS) is an aggressive hematologic malignancy and is considered a pre-leukemic phase. T-MDS is associated with prior exposure to chemo- and radiotherapy that potentially results in DNA damage...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29435031/analysis-of-radiation-effects-in-two-irradiated-tumor-spheroid-models
#6
Afkar Al-Ramadan, Anja C Mortensen, Jörgen Carlsson, Marika V Nestor
Multicellular spheroids have proven suitable as three-dimensional in vivo-like models of non-vascularized micrometastases. Unlike monolayer-based models, spheroids mirror the cellular milieu and the pathophysiological gradients inside tumor nodules. However, there is limited knowledge of the radiation effects at the molecular level in spheroids of human origin. The present study is a presentation of selected cell biological processes that may easily be analyzed with methods available at routine pathology laboratories...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29433103/exposure-to-organophosphate-flame-retardants-of-hotel-room-attendants-in-wuhan-city-china
#7
Yun Tao, Yinzhu Shang, Jing Li, Jingwen Feng, Zhenyu He, Adrian Covaci, Peng Wang, Jing Luo, Xiang Mao, Bin Shi, Liqin Hu, Dan Luo, Surong Mei
Indoor environments provide sources of exposure to organophosphate flame retardants (PFRs), which are artificially synthesized fire-protecting agents used as additives in interior products. As public spaces, hotels are required to meet stricter fire-precaution criteria. As such, room attendants may be exposed to higher levels of PFRs. Our goal was to characterize the exposure of hotel room attendants to PFRs by measuring metabolites in their urine and the corresponding parent PFRs in dust and hand-wipes collected from 27 hotels located in Wuhan City, China...
February 9, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29432262/increased-radiation-but-no-benefits-in-pedicle-screw-accuracy-with-navigation-versus-a-freehand-technique-in-scoliosis-surgery
#8
Wiktor Urbanski, Wojciech Jurasz, Michal Wolanczyk, Miroslaw Kulej, Piotr Morasiewicz, Szymon Lukasz Dragan, Rafal Zaluski, Grzegorz Miekisiak, Szymon Feliks Dragan
BACKGROUND: The clinical value of pedicle screws in spinal deformity surgery is well known; however, screw insertion is demanding and sometimes associated with complications. Navigation systems based on intraoperatively obtained three-dimensional (3-D) images were developed to minimize pedicle screw misplacements. However, there is a lack of data confirming superiority of navigation above other techniques. There are also concerns regarding increased radiation used during the procedure...
February 8, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29429512/effect-of-human-umbilical-cord-blood-derived-cd34-hematopoietic-stem-cell-on-the-expression-of-wnt4-and-p53-genes-in-a-rat-model-of-hepatocellular-carcinoma
#9
Rania Naiem Sherif, Hussein Abdellatif, Noha Hazem, Neven A Ebrahim, Dalia Saleh, Gamal Shiha, Huda Eltahry, Kamal G Botros, Omar M Gabr
BACKGROUND AND AIM OF THE WORK: Hepatocellular carcinoma (HCC) is the most frequent primary liver malignancy. Chronic liver injuries as chronic hepatitis C and hepatitis B viruses, aflatoxins consumption and nonalcoholic fatty liver disease are well-established causes of HCC. HCC is associated with a series of molecular changes, as alternation in glypican-3, P53 expression and Wnt/β-catenin pathway. Hepatic cancer progenitor cells could contribute to HCC development. This research aimed to study the effectiveness of human CD34+ hematopoietic stem cell on Wnt4 and P53 genes expression, histopathological grading and hepatic progenitor cells percentage in HCC rat model...
February 2018: Tissue & Cell
https://www.readbyqxmd.com/read/29426845/short-term-effect-of-ambient-ozone-on-daily-emergency-room-visits-in-beijing-china
#10
Yaohua Tian, Xiao Xiang, Juan Juan, Jing Song, Yaying Cao, Chao Huang, Man Li, Yonghua Hu
Little is known about the acute effects of ozone on morbidity risk in China. We conducted a time-series study to examine the association between ozone and daily emergency room visits (ERVs) in Beijing, China. We identified 7,088,309 ERVs between January 1, 2014 and December 31, 2015. A generalized additive model with Poisson regression incorporating penalized spline functions was employed to analyze ERVs in association with daily 8-h maximum ozone concentrations. An increase of 10 μg/m3 of same-day ozone concentration was significantly associated with a 0...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29426028/performance-of-low-cost-monitors-to-assess-household-air-pollution
#11
A Curto, D Donaire-Gonzalez, J Barrera-Gómez, J D Marshall, M J Nieuwenhuijsen, G A Wellenius, C Tonne
Exposure to household air pollution is a leading cause of morbidity and mortality globally. However, due to the lack of validated low-cost monitors with long-lasting batteries in indoor environments, most epidemiologic studies use self-reported data or short-term household air pollution assessments as proxies of long-term exposure. We evaluated the performance of three low-cost monitors measuring fine particulate matter (PM2.5) and carbon monoxide (CO) in a wood-combustion experiment conducted in one household of Spain for 5 days (including the co-location of 2 units of HAPEX and 3 units of TZOA-R for PM2...
February 6, 2018: Environmental Research
https://www.readbyqxmd.com/read/29425383/dual-use-of-e-cigarettes-and-traditional-cigarettes-among-adolescents-in-taiwan-2014-2016
#12
Pei-Ching Chen, Li-Chuan Chang, Chieh Hsu, Yue-Chune Lee
Introduction: We investigated the use of electronic cigarettes (e-cigarettes) with traditional cigarettes among adolescents during 2014 to 2016 to identify risk factors for using e-cigarettes only, traditional cigarettes only, or both products. Methods: We used cross-sectional data from the Taiwan Global Youth Tobacco Survey, (conducted over a 3-year period by the Health Promotion Administration, Ministry of Health and Welfare, Taiwan), which is representative of tobacco use among adolescents aged 12-18 years...
February 2, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29422373/international-commission-for-mountain-emergency-medicine-consensus-guidelines-for-on-site-management-and-transport-of-patients-in-canyoning-incidents
#13
REVIEW
Giacomo Strapazzon, Oliver Reisten, Fabien Argenone, Ken Zafren, Greg Zen-Ruffinen, Gordon L Larsen, Inigo Soteras
Canyoning is a recreational activity that has increased in popularity in the last decade in Europe and North America, resulting in up to 40% of the total search and rescue costs in some geographic locations. The International Commission for Mountain Emergency Medicine convened an expert panel to develop recommendations for on-site management and transport of patients in canyoning incidents. The goal of the current review is to provide guidance to healthcare providers and canyoning rescue professionals about best practices for rescue and medical treatment through the evaluation of the existing best evidence, focusing on the unique combination of remoteness, water exposure, limited on-site patient management options, and technically challenging terrain...
February 5, 2018: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/29416696/tnfr-tnf-%C3%AE-signaling-pathway-regulates-apoptosis-of-alveolar-macrophages-in-coal-workers-pneumoconiosis
#14
Qing-Zeng Qian, Xiang-Ke Cao, Hai-Yan Liu, Guo-Ying Zheng, Qing-Qiang Qian, Fu-Hai Shen
We explored the role of TNFR/TNF-α signalingin apoptosis among alveolar macrophages (AM) and its relevance to the development of coal workers' pneumoconiosis (CWP). Purified alveolar macrophages (AMs) were prepared from bronchoalveolar lavage fluid harvested from 366 CWP patients and 120 healthy subjects enrolled inthe study. The purified AMs were then divided into control, SOD, anti-TNFR, TNFR and NFkB inhibitor groups and analyzed for apoptosis usingflow cytometry (sub-diploid peak) and western blotting (Bcl-2, Caspase-3 and Caspase-8 expression)...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29414890/who-environmental-noise-guidelines-for-the-european-region-a-systematic-review-on-environmental-noise-and-cognition
#15
REVIEW
Charlotte Clark, Katarina Paunovic
This systematic review assesses the quality of the evidence across individual studies on the effect of environmental noise (road traffic, aircraft, and train and railway noise) on cognition. Quantitative non-experimental studies of the association between environmental noise exposure on child and adult cognitive performance published up to June 2015 were reviewed: no limit was placed on the start date for the search. A total of 34 papers were identified, all of which were of child populations. 82% of the papers were of cross-sectional design, with fewer studies of longitudinal or intervention design...
February 7, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29413887/parental-alcohol-consumption-and-adult-children-s-educational-attainment
#16
Lucia Mangiavacchi, Luca Piccoli
This study analyses whether an excessive parental alcohol consumption during childhood can affect long run children's educational attainments. Using 19 waves of the Russia Longitudinal Monitoring Survey (RLMS), where individuals and their families are followed from childhood to adulthood, this study analyses parental alcohol consumption during childhood (between 1994 and 2001) and its relation with children's educational attainment about twelve years later (from 2005 to 2014). Panel estimations show that mother's excessive alcohol consumption during childhood is consistently negatively associated with children educational outcomes, as years of education, the highest education grade achieved and the probability of having a tertiary education degree, a finding that is robust to possible endogeneity issues...
December 29, 2017: Economics and Human Biology
https://www.readbyqxmd.com/read/29412695/high-injury-burden-in-elite-adolescent-athletes-a-52-week-prospective-study
#17
Philip von Rosen, Annette Heijne, Anna Frohm, Cecilia Friden, Anders Kottorp
CONTEXT:   Our understanding of the injury burden in elite adolescent athletes in most sports is limited or unknown because of the lack of prospective, long-term injury studies. OBJECTIVE:   To describe injury patterns in terms of type, location, prevalence and incidence, recurrence, and severity grade; time to first injury; and prevalence of illness in elite adolescent athletes and to compare differences in injury data by sex and sport type. DESIGN:   Cohort study...
February 7, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29411031/prevalence-of-fetal-alcohol-spectrum-disorders-in-4-us-communities
#18
Philip A May, Christina D Chambers, Wendy O Kalberg, Jennifer Zellner, Haruna Feldman, David Buckley, David Kopald, Julie M Hasken, Ronghui Xu, Gordon Honerkamp-Smith, Howard Taras, Melanie A Manning, Luther K Robinson, Margaret P Adam, Omar Abdul-Rahman, Keith Vaux, Tamison Jewett, Amy J Elliott, Julie A Kable, Natacha Akshoomoff, Daniel Falk, Judith A Arroyo, Dale Hereld, Edward P Riley, Michael E Charness, Claire D Coles, Kenneth R Warren, Kenneth Lyons Jones, H Eugene Hoyme
Importance: Fetal alcohol spectrum disorders are costly, life-long disabilities. Older data suggested the prevalence of the disorder in the United States was 10 per 1000 children; however, there are few current estimates based on larger, diverse US population samples. Objective: To estimate the prevalence of fetal alcohol spectrum disorders, including fetal alcohol syndrome, partial fetal alcohol syndrome, and alcohol-related neurodevelopmental disorder, in 4 regions of the United States...
February 6, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29409206/percutaneous-distal-osteotomy-of-lesser-metatarsals-dmmo-for-treatment-of-metatarsalgia-with-metatarsophalangeal-instability
#19
Bruno Magnan, Ingrid Bonetti, Stefano Negri, Tommaso Maluta, Carlo Dall'Oca, Elena Samaila
BACKGROUND: Clinical and radiological results of percutaneous distal metatarsal minimally invasive osteotomy (DMMO) of the lesser rays for surgical treatment of primary metatarsalgia due to plantar overpressure with metatarsophalangeal instability are described. The aim of this prospective study was to assess the efficacy, feasibility and safety of this minimally invasive surgical (MIS) technique, verifying the possibility to lower the complication rate related to surgical exposures, to reduce operating times with comparable functional and cosmetic results to those reported with traditional open procedures...
April 27, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29407680/factors-associated-with-successful-vs-unsuccessful-smoking-cessation-data-from-a-nationally-representative-study
#20
Fabienne El-Khoury Lesueur, Camille Bolze, Maria Melchior
INTRODUCTION: A substantial proportion of smokers who attempt to stop smoking relapse in the first months. Yet to date, there is limited understanding of the predictors of smoking attempts and their success. We examine the role of tobacco use characteristics, other substance-related factors, as well as socio-demographic characteristics in relation to successful and unsuccessful smoking cessation. METHODS: DePICT (Description des Perceptions, Images, et Comportements liés au Tabagisme) is a nationally representative sample of adults aged between 18 and 64years residing in metropolitan France, who were interviewed by telephone survey (n=4342)...
February 1, 2018: Addictive Behaviors
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