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https://www.readbyqxmd.com/read/29224757/reproducing-severe-acute-subglottic-stenosis-in-a-rabbit-model
#1
Wesley R McIlwain, Paul R Wistermayer, Tyler P Swiss, Shannon T Marko, Nicholas M Ieronimakis, Derek J Rogers
OBJECTIVES: The objectives of this study were to develop an animal model with consistent, severe subglottic stenosis (SGS), and to develop the timeline needed for intervention to limit rabbit mortality. METHODS: Subglottic stenosis was created endoscopically using either a nylon or polypropylene brush in sixteen New Zealand White rabbits. The subglottic cross-sectional area was measured endoscopically using a right-angled probe and an open source image analysis software The cross-sectional areas of the stenotic and native airways were compared to calculate the subglottic stenosis percentage and Myer-Cotton grade classification...
December 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29223598/prognosis-and-treatment-of-positive-peritoneal-cytology-in-early-endometrial-cancer-matched-cohort-analyses-from-the-national-cancer-database
#2
Brandon-Luke L Seagle, Amy L Alexander, Taliya Lantsman, Shohreh Shahabi
BACKGROUND: While positive peritoneal cytology is no longer included among the endometrial cancer staging criteria, FIGO recommends continued collection of pelvic washings for cytology in order to produce additional data that may be used to determine the significance of positive cytology for prognosis and treatment of endometrial cancer. OBJECTIVES: To validate that positive cytology is a predictor of decreased survival in early endometrial cancer and to test if adjuvant chemotherapy for positive cytology is associated with increased survival...
December 6, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29223563/sexual-identity-adverse-childhood-experiences-and-suicidal-behaviors
#3
Kristen Clements-Nolle, Taylor Lensch, Amberlee Baxa, Christopher Gay, Sandra Larson, Wei Yang
PURPOSE: The objective of this study was to examine the influence of sexual identity and adverse childhood experiences (ACEs) on suicidal behaviors in a population-based sample of high school students. METHODS: A two-stage cluster random sampling design was used to recruit 5,108 students from 97 high schools. A total of 4,955 students (97%) provided information that allowed for classification of sexual identity into three groups: (1) lesbian, gay, or bisexual (LGB) (10%); (2) not sure (4...
December 6, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29219092/systematic-review-of-the-relationships-between-sedentary-behaviour-and-health-indicators-in-the-early-years-0-4%C3%A2-years
#4
Veronica J Poitras, Casey E Gray, Xanne Janssen, Salome Aubert, Valerie Carson, Guy Faulkner, Gary S Goldfield, John J Reilly, Margaret Sampson, Mark S Tremblay
BACKGROUND: The purpose of this systematic review was to examine the relationships between sedentary behaviour (SB) and health indicators in children aged 0 to 4 years, and to determine what doses of SB (i.e., duration, patterns [frequency, interruptions], and type) were associated with health indicators. METHODS: Online databases were searched for peer-reviewed studies that met the a priori inclusion criteria: population (apparently healthy, 1 month to 4.99 years), intervention/exposure and comparator (durations, patterns, and types of SB), and outcome/health indicator (critical: adiposity, motor development, psychosocial health, cognitive development; important: bone and skeletal health, cardiometabolic health, fitness, risks/harm)...
November 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29219090/systematic-review-of-the-relationships-between-physical-activity-and-health-indicators-in-the-early-years-0-4%C3%A2-years
#5
Valerie Carson, Eun-Young Lee, Lyndel Hewitt, Cally Jennings, Stephen Hunter, Nicholas Kuzik, Jodie A Stearns, Stephanie Powley Unrau, Veronica J Poitras, Casey Gray, Kristi B Adamo, Ian Janssen, Anthony D Okely, John C Spence, Brian W Timmons, Margaret Sampson, Mark S Tremblay
BACKGROUND: Given the rapid development during the early years (0-4 years), an understanding of the health implications of physical activity is needed. The purpose of this systematic review was to examine the relationships between objectively and subjectively measured physical activity and health indicators in the early years. METHODS: Electronic databases were originally searched in April, 2016. Included studies needed to be peer-reviewed, written in English or French, and meet a priori study criteria...
November 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29219078/systematic-review-of-the-relationships-between-sleep-duration-and-health-indicators-in-the-early-years-0-4%C3%A2-years
#6
Jean-Philippe Chaput, Casey E Gray, Veronica J Poitras, Valerie Carson, Reut Gruber, Catherine S Birken, Joanna E MacLean, Salomé Aubert, Margaret Sampson, Mark S Tremblay
BACKGROUND: The objective of this systematic review was to examine for the first time the associations between sleep duration and a broad range of health indicators in children aged 0 to 4 years. METHODS: Electronic databases were searched with no limits on date or study design. Included studies (published in English or French) were peer-reviewed and met the a priori determined population (apparently healthy children aged 1 month to 4.99 years), intervention/exposure/comparator (various sleep durations), and outcome criteria (adiposity, emotional regulation, cognitive development, motor development, growth, cardiometabolic health, sedentary behaviour, physical activity, quality of life/well-being, and risks/injuries)...
November 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29216926/pro-inflammatory-adjuvant-properties-of-pigment-grade-titanium-dioxide-particles-are-augmented-by-a-genotype-that-potentiates-interleukin-1%C3%AE-processing
#7
Sebastian Riedle, Laetitia C Pele, Don E Otter, Rachel E Hewitt, Harjinder Singh, Nicole C Roy, Jonathan J Powell
BACKGROUND: Pigment-grade titanium dioxide (TiO2) particles are an additive to some foods (E171 on ingredients lists), toothpastes, and pharma-/nutraceuticals and are absorbed, to some extent, in the human intestinal tract. TiO2 can act as a modest adjuvant in the secretion of the pro-inflammatory cytokine interleukin 1β (IL-1β) when triggered by common intestinal bacterial fragments, such as lipopolysaccharide (LPS) and/or peptidoglycan. Given the variance in human genotypes, which includes variance in genes related to IL-1β secretion, we investigated whether TiO2 particles might, in fact, be more potent pro-inflammatory adjuvants in cells that are genetically susceptible to IL-1β-related inflammation...
December 8, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29215155/prophylactic-antibiotics-before-cord-clamping-in-cesarean-delivery-a-systematic-review
#8
Claudia Bollig, Monika Nothacker, Cornelius Lehane, Edith Motschall, Britta Lang, Joerg J Meerpohl, Christine M Schmucker
The number of clinical trials investigating the optimal timing of prophylactic antibiotics in cesarean section increased rapidly over the last few years. We conducted a systematic review to inform up-to date evidence-based guidelines to prevent postpartum infectious morbidity in the mother and rule out any safety issues related to antepartum antibiotic exposure in infants MATERIAL AND METHODS: Four bibliographic databases were searched for published reports of trials. Ongoing or unpublished studies were searched in Clinicaltrials...
December 7, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29214394/serious-adverse-events-associated-with-anti-tumor-necrosis-factor-alpha-agents-in-pediatric-onset-inflammatory-bowel-disease-and-juvenile-idiopathic-arthritis-in-a-real-life-setting
#9
Serena Pastore, Samuele Naviglio, Arianna Canuto, Loredana Lepore, Stefano Martelossi, Alessandro Ventura, Andrea Taddio
OBJECTIVES: Anti-tumor necrosis factor alpha (anti-TNF-α) agents are generally well tolerated, yet they can be associated with serious adverse events (SAEs) in a minority of patients. We examined the incidence of SAEs in a pediatric referral center for chronic rheumatologic and gastroenterological inflammatory disorders. METHODS: Retrospective analysis of SAEs occurring during treatment with anti-TNF-α agents in patients with juvenile idiopathic arthritis (JIA) (n = 78)  or pediatric-onset inflammatory bowel disease (IBD) (n = 105) seen at the Institute for Maternal and Child Health IRCCS "Burlo Garofolo" in Trieste, Italy, between June 2001 and February 2016...
December 6, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/29214149/measurements-of-radiofrequency-radiation-with-a-body-borne-exposimeter-in-swedish-schools-with-wi-fi
#10
Lena K Hedendahl, Michael Carlberg, Tarmo Koppel, Lennart Hardell
Introduction: Wireless access to the Internet is now commonly used in schools. Many schools give each student their own laptop and utilize the laptops and wireless fidelity (Wi-Fi) connection for educational purposes. Most children also bring their own mobile phones to school. Since children are obliged by law to attend school, a safe environment is important. Lately, it has been discussed if radiofrequency (RF) radiation can have long-term adverse effects on children's health. Method: This study conducted exposimetric measurements in schools to assess RF emissions in the classroom by measuring the teachers' RF exposure in order to approximate the children's exposure...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29213254/blue-light-therapy-following-mild-traumatic-brain-injury-effects-on-white-matter-water-diffusion-in-the-brain
#11
Sahil Bajaj, John R Vanuk, Ryan Smith, Natalie S Dailey, William D S Killgore
Mild traumatic brain injury (mTBI) is a common and often inconspicuous wound that is frequently associated with chronic low-grade symptoms and cognitive dysfunction. Previous evidence suggests that daily blue wavelength light therapy may be effective at reducing fatigue and improving sleep in patients recovering from mTBI. However, the effects of light therapy on recovering brain structure remain unexplored. In this study, we analyzed white matter diffusion properties, including generalized fractional anisotropy, and the quantity of water diffusion in isotropic (i...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29210800/molecular-modifiers-of-hormone-receptor-action-decreased-androgen-receptor-expression-in-mismatch-repair-deficient-endometrial-endometrioid-adenocarcinoma
#12
Qiong Gan, Suzanne Crumley, Russell R Broaddus
Endometrial endometrioid carcinoma is related to estrogen excess and expression of estrogen and progesterone receptors. Epidemiological evidence suggests that exposure to elevated androgens, as in polycystic ovarian syndrome, increases the risk of endometrial cancer. Factors impacting androgen receptor (AR) expression are not well studied. Mismatch repair (MMR) deficiency due to MLH1 gene methylation is one of the most common molecular alterations in endometrial cancer, occurring in 15% to 20% of cases. MLH1 methylation can be associated with decreased expression of other genes, so we examined the effect of MMR status on AR expression...
November 28, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29208662/antenatal-corticosteroids-in-impending-preterm-deliveries-before-25-weeks-gestation
#13
Mangesh Deshmukh, Sanjay Patole
Antenatal corticosteroid (ANC) use before 25 weeks' gestation is controversial. Our previous systematic review (eight observational studies, n=10 109) showed that ANC exposure was associated with significantly reduced mortality and severe intraventricular haemorrhage (IVH)/periventricular leukomalacia (PVL) in neonates born <25 weeks. We update our review by adding data (n=3334) from a recent study. We used Cochrane methodology and summarised the results using GRADE (The Grading of Recommendations Assessment, Development and Evaluation) guidelines...
December 5, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29208078/community-junior-sport-sponsorship-an-online-experiment-assessing-children-s-responses-to-unhealthy-food-v-pro-health-sponsorship-options
#14
Helen Dixon, Maree Scully, Melanie Wakefield, Bridget Kelly, Simone Pettigrew
OBJECTIVE: To explore children's responses to sponsorship of community junior sport by unhealthy food brands and investigate the utility of alternative, pro-health sponsorship options. DESIGN: Between-subjects experiment, with four sponsorship conditions: A, non-food branding (control); B, unhealthy food branding; C, healthier food branding; D, obesity prevention campaign branding. SETTING: Online experiment conducted in schools. Participants were shown a junior sports pack for their favourite sport that contained merchandise with branding representing their assigned sponsorship condition...
December 6, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/29207534/effects-of-the-macular-carotenoid-lutein-in-human-retinal-pigment-epithelial-cells
#15
Xiaoming Gong, Christian S Draper, Geoffrey S Allison, Raju Marisiddaiah, Lewis P Rubin
Retinal pigment epithelial (RPE) cells are central to retinal health and homoeostasis. Oxidative stress-induced damage to the RPE occurs as part of the pathogenesis of age-related macular degeneration and neovascular retinopathies (e.g., retinopathy of prematurity, diabetic retinopathy). The xanthophyll carotenoids, lutein and zeaxanthin, are selectively taken up by the RPE, preferentially accumulated in the human macula, and transferred to photoreceptors. These macular xanthophylls protect the macula (and the broader retina) via their antioxidant and photo-protective activities...
December 4, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29205426/systematic-review-with-meta-analysis-thiopurines-decrease-the-risk-of-colorectal-neoplasia-in-patients-with-inflammatory-bowel-disease
#16
REVIEW
M J Lu, X Y Qiu, X Q Mao, X T Li, H J Zhang
BACKGROUND: Patients with inflammatory bowel disease (IBD) have a high risk of developing colorectal neoplasia. AIM: To investigate whether thiopurines can decrease the risk of developing colorectal neoplasia in patients with ulcerative colitis (UC) or Crohn's disease (CD). METHODS: We conducted a meta-analysis of 24 observational studies involving 76,999 participants to evaluate the risks of developing colorectal neoplasia in IBD patients receiving thiopurine treatment...
December 4, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29205406/systematic-review-and-network-meta-analysis-first-and-second-line-pharmacotherapy-for-moderate-severe-ulcerative-colitis
#17
S Singh, M Fumery, W J Sandborn, M H Murad
BACKGROUND: There are limited data to inform positioning of agents for treating moderate-severe ulcerative colitis (UC). AIM: To assess comparative efficacy and safety of different therapies as first-line (biologic-naïve) and second-line (prior exposure to anti-tumour necrosis factor(TNF)-α) agents for moderate-severe UC, through a systematic review and network meta-analysis, and appraise quality of evidence (QoE) using grading of recommendations, assessment, development and evaluation (GRADE) approach...
December 4, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29204846/the-costly-consequences-of-not-being-socially-and-behaviorally-ready-to-learn-by-kindergarten-in-baltimore-city
#18
Amie F Bettencourt, Deborah Gross, Grace Ho, Nancy Perrin
Social, emotional, and behavioral skills are foundational to learning and long-term success. However, poverty and exposure to adverse childhood experiences reduce the chances of children entering kindergarten socially-behaviorally ready to learn. This study examined the unique impact of 5-year-old children (N = 11,412) entering kindergarten not socially-behaviorally ready on three costly school outcomes by fourth grade in Baltimore City Public Schools: being retained in grade, receiving services and supports through an IEP or 504 plan, and being suspended/expelled...
December 4, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/29203314/endoscopic-transseptal-approach-with-posterior-nasal-spine-removal-a-wide-surgical-corridor-to-the-craniovertebral-junction-and-odontoid-technical-note-and-case-series
#19
Zefferino Rossini, Davide Milani, Federico Nicolosi, Francesco Costa, Giovanni Battista Lasio, Vincenzo Antonio D'Angelo, Maurizio Fornari, Giovanni Colombo
BACKGROUND: Transnasal approach to lesions involving the craniovertebral junction represents a technical challenge because of limited inferior exposure. The authors describe the endoscopic transseptal approach (ETsA) with posterior nasal spine (PNS) removal; this technique can create a wide exposition of the craniovertebral junction increasing the caudal exposure. METHODS: On patients undergoing anterior craniovertebral junction decompression, we calculated the degree of exposure on the sagittal plan through a paraseptal route, an ETsA without and with PNS removal...
December 1, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29202445/balancing-the-benefits-and-harms-of-thyroid-cancer-surveillance-in-survivors-of-childhood-adolescent-and-young-adult-cancer-recommendations-from-the-international-late-effects-of-childhood-cancer-guideline-harmonization-group-in-collaboration-with-the-pancaresurfup
#20
REVIEW
S C Clement, L C M Kremer, F A Verburg, J H Simmons, M Goldfarb, R P Peeters, E K Alexander, E Bardi, E Brignardello, L S Constine, C A Dinauer, V M Drozd, F Felicetti, E Frey, A Heinzel, M M van den Heuvel-Eibrink, S A Huang, T P Links, K Lorenz, R L Mulder, S J Neggers, E J M Nieveen van Dijkum, K C Oeffinger, R R van Rijn, S A Rivkees, C M Ronckers, A B Schneider, R Skinner, J D Wasserman, T Wynn, M M Hudson, P C Nathan, H M van Santen
Radiation exposure to the thyroid gland during treatment of childhood, adolescent and young adult cancer (CAYAC) may cause differentiated thyroid cancer (DTC). Surveillance recommendations for DTC vary considerably, causing uncertainty about optimum screening practices. The International Late Effects of Childhood Cancer Guideline Harmonization Group, in collaboration with the PanCareSurFup Consortium, developed consensus recommendations for thyroid cancer surveillance in CAYAC survivors. These recommendations were developed by an international multidisciplinary panel that included 33 experts in relevant medical specialties who used a consistent and transparent process...
November 14, 2017: Cancer Treatment Reviews
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