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https://www.readbyqxmd.com/read/29916577/-classification-and-risk-assessment-complementary-or-mutually-exclusive-approaches
#1
Angelo Moretto
OBJECTIVES: Most classification schemes are based on hazard identification: this is particularly true for carcinogenic and reproductive effects. METHODS: These schemes are no longer adequate to take adequate decisions on risk management, and they appear outmoded. In addition, the induce communication and perception problems in the population, causing health scares and anxiety that are difficult to control and recover. RESULTS: Risk assessment requires an estimation of human exposure to be compared with the safe dose for humans (exposure or intake limits) estimated after hazard characterization based on dose-response relationship...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29915805/next-generation-sequencing-based-detection-of-germline-and-somatic-alterations-in-a-patient-with-four-metachronous-primary-tumors
#2
Madhuri Martin, Joshua K Sabari, Gulisa Turashvili, Darragh F Halpenny, Hira Rizvi, Natalie Shapnik, Vicky Makker
Introduction: Multiple primary tumors (MPTs) are defined as two or more separate synchronous or metachronous neoplasms occurring in different sites in the same individual. These tumors differ in histology, as well as primary sites from which they arise. Risk factors associated with the occurrence of MPTs include germline alterations, exposure to prior cancer therapies, occupational hazards, and lifestyle and behavioral influences. Case report: We present a case of a patient who was diagnosed with four metachronous primary tumors...
May 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29914965/a-new-locus-of-drug-resistance-in-the-human-cytomegalovirus-ul56-gene-revealed-by-in-vitro-exposure-to-letermovir-and-ganciclovir
#3
Sunwen Chou, L Elizabeth Satterwhite, Ronald J Ercolani
Letermovir is a human cytomegalovirus (CMV) terminase inhibitor recently approved as prophylaxis in stem cell transplant recipients. In further studies of emerging drug resistance, a baseline laboratory CMV strain was serially propagated in cell culture under a combination of letermovir and ganciclovir. In 8 experiments, UL56 terminase gene mutations were detected beginning at 10 passages, including novel amino acid substitutions V236A, L328V and A365S, in a region previously associated with letermovir resistance...
June 18, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29914796/convection-enhanced-delivery-for-diffuse-intrinsic-pontine-glioma-a-single-centre-dose-escalation-phase-1-trial
#4
Mark M Souweidane, Kim Kramer, Neeta Pandit-Taskar, Zhiping Zhou, Sofia Haque, Pat Zanzonico, Jorge A Carrasquillo, Serge K Lyashchenko, Sunitha B Thakur, Maria Donzelli, Ryan S Turner, Jason S Lewis, Nai-Kong V Cheung, Steven M Larson, Ira J Dunkel
BACKGROUND: Diffuse intrinsic pontine glioma is one of the deadliest central nervous system tumours of childhood, with a median overall survival of less than 12 months. Convection-enhanced delivery has been proposed as a means to efficiently deliver therapeutic agents directly into the brainstem while minimising systemic exposure and associated toxic effects. We did this study to evaluate the safety of convection-enhanced delivery of a radioimmunotherapy agent targeting the glioma-associated B7-H3 antigen in children with diffuse intrinsic pontine glioma...
June 15, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29914409/adverse-childhood-experiences-among-patients-with-substance-use-disorders-at-a-referral-psychiatric-hospital-in-kenya
#5
Sarah Kanana Kiburi, Keneilwe Molebatsi, Anne Obondo, Mary W Kuria
BACKGROUND: Substance use disorders are a major cause of health and social problems worldwide. Research evidence shows a strong graded relationship of adverse childhood experiences and substance use in adulthood. This study aimed at determining the prevalence of adverse childhood experiences and their association with substance use among patients with substance use disorders. METHOD: The study used a descriptive cross-sectional design. A total of 134 patients aged 18 years and above receiving inpatient treatment for substance use disorders were recruited into the study...
June 18, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29912448/nuclear-stress-testing-referrals-time-for-a-novel-radiation-sparing-approach
#6
Steven C Romero, Joshua P Dettmer
Background: A Science Advisory from the American Heart Association implores clinicians to always consider equivalent tests which do not use ionizing radiation. Intersocietal guidelines describe only two scenarios where a nuclear stress test is the only option for non-invasive evaluation: left bundle branch block (LBBB) and ventricular-paced rhythm; otherwise, treadmill EKG and stress echocardiography are feasible. This study sought to measure our compliance with appropriate use criteria,6 and then to apply our own Novel Radiation Sparing Approach (NRSA) to measure what percentage could have been evaluated without radiation...
April 18, 2018: Military Medicine
https://www.readbyqxmd.com/read/29911956/social-support-violence-exposure-and-mental-health-among-young-south-african-adolescents
#7
Annette Humm, Debra Kaminer, Anneli Hardy
OBJECTIVE: Cumulative violence exposure has been associated with both internalising and externalising difficulties in youth. Therefore, it is important to identify protective factors that may ameliorate both exposure to and the impact of cumulative violence. This study aimed to identify sources of perceived social support amongst early adolescents in a low-income, high-violence community in South Africa, and to examine the association of perceived support with exposure to violence and with the severity of depression, aggression and conduct disorder symptoms...
May 2018: Journal of Child and Adolescent Mental Health
https://www.readbyqxmd.com/read/29911574/hyperalgesia-and-allodynia-to-superficial-and-deep-tissue-mechanical-stimulation-within-and-outside-of-the-uvb-irradiated-area-in-human-skin
#8
Silvia Lo Vecchio, Lars J Petersen, Sara Finocchietti, Parisa Gazerani, Lars Arendt-Nielsen, Thomas Graven-Nielsen
Background and aims The ultraviolet-B (UVB) inflammatory model is a well-established model of inflammatory pain. This study investigated whether UVB-induced cutaneous inflammation would enhance pain responses from the underlying deep somatic areas. Methods Skin inflammation was induced, in 24 healthy volunteers, by UVB irradiation (three times of the individual minimal erythema UVB dose) in square-shaped areas on the forearm and lower back. Assessments of cutaneous blood flow, pin-prick thresholds, pressure pain thresholds and tolerance, stimulus-response functions relating graded pressure stimulations and pain intensity (visual analogue scale, VAS) were performed within and outside the irradiated area...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29909713/how-does-exposure-to-violence-affect-school-delay-and-academic-motivation-for-adolescents-living-in-socioeconomically-disadvantaged-communities-in-south-africa
#9
Rocio Herrero Romero, James Hall, Lucie Cluver, Franziska Meinck, Eleanor Hinde
To date, little is known about the effects of violence on the educational outcomes of adolescents in disadvantaged communities in South Africa. In response, self-report data were collected from a socioeconomically disadvantaged sample of 503 adolescents aged 10 to 18 participating in a child abuse prevention trial in the Eastern Cape. Adolescents were purposively selected in the trial. This study applies Latent Profile Analysis (LPA) to examine relationships between past-month exposure to violence, school delay, and academic motivation...
June 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29908436/adverse-experiences-in-infancy-and-toddlerhood-relations-to-adaptive-behavior-and-academic-status-in-middle-childhood
#10
Lorraine M McKelvey, Nicola Conners Edge, Glenn R Mesman, Leanne Whiteside-Mansell, Robert H Bradley
Findings from the Adverse Childhood Experiences (ACE) study articulated the negative effects of childhood trauma on long-term well-being. The purpose of the current study is to examine the associations between ACEs experienced in infancy and toddlerhood and adaptive behavior and academic status in middle childhood. We used data collected from a sample of low-income families during the impacts study of Early Head Start (EHS). Data were collected by trained interviewers demonstrating at least 85% reliability with protocols...
June 13, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29903301/-determination-of-polycyclic-aromatic-hydrocarbons-in-girls-and-association-between-polycyclic-aromatic-hydrocarbons-exposure-and-puberty-timing
#11
Xu Deng, Qin Liu, Shudan Liu, Wenyan Li, Yiwen Chen, Yi Wen, Yan Luo
OBJECTIVE: To develop amethod for simultaneous determination of four metabolites of polycyclic aromatic hydrocarbons( PAHs), and to study the association between puberty timing of girls and PAHs exposure levels in Chongqing. METHODS: Through purposeful sampling, questionnaire survey of the general information, physical examination of growth and development, collection of urine sample were carried out among1-4 grades of four primary school girls in a district of Chongqing...
September 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29902578/the-impact-of-the-effectiveness-of-gata3-as-a-prognostic-factor-in-breast-cancer
#12
Fararjeh-Salah Abdul Fattah, Shih-Hsin Tu, Li-Ching Chen, Yun-Ru Liu, Yen-Kuang Lin, Hang-Lung Chang, Hui-Wen Chang, Chih-Hsiung Wu, Wendy-Hwang Verslues, Yuan-Soon Ho
The transcription factor GATA3 plays a significant role in mammary gland development and differentiation. We analyzed expression of GATA3 in breast cancer (BC) cell lines and clinical specimens from BC patients in Taiwan. Semi-quantitative reverse transcriptase (RT)-polymerase chain reaction (PCR), quantitative real-time PCR carried out to determine the mRNA level of GATA3 from 241 pairs of matched tumor and adjacent normal tissues from anonymous female donors. GATA3 immunohistochemistry (IHC) staining and H-score were performed (n=25)...
June 11, 2018: Human Pathology
https://www.readbyqxmd.com/read/29901531/safety-of-electromagnetic-navigation-bronchoscopy-in-patients-with-copd-results-from-the-navigate-study
#13
Christopher W Towe, Michael A Nead, Otis B Rickman, Erik E Folch, Sandeep J Khandhar, Yaron Perry, Philip A Linden
BACKGROUND: Electromagnetic navigation bronchoscopy (ENB) aids in the localization of lung lesions for biopsy and/or to guide fiducial or dye marking for stereotactic radiation or surgical localization. This study assessed ENB safety in patients with chronic obstructive pulmonary disease (COPD) and/or poor lung function. METHODS: NAVIGATE is a prospective, multicenter, observational study of ENB. This substudy analyzed the 1-month follow-up of the first 1000 enrolled subjects...
June 12, 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29901290/-outcomes-of-er-yag-laser-treatment-of-stress-urinary-incontinence-in-women
#14
A I Neimark, A Yu Yakovleva, G A Lapii
AIM: To evaluate the effectiveness of a new method of treatment for stress urinary incontinence in women using an ER: YAG laser in SMOOTH mode and investigate pathophysiological and pathomorphological changes induced by erbium laser. MATERIALS AND METHODS: This study comprised 98 women aged 37-63 years, who between 2014 and 2016 were diagnosed with SUI (type 1 and 2a, 2b) and grade 0-2 vaginal prolapse. The treatment was performed with a 2940 nm Er:YAG laser (Fotona, Slovenia) using a SMOOTH mode...
May 2018: Urologii︠a︡
https://www.readbyqxmd.com/read/29899763/prospective-single-center-implementation-and-response-evaluation-of-pressurized-intraperitoneal-aerosol-chemotherapy-pipac-for-peritoneal-metastasis
#15
Martin Graversen, Sönke Detlefsen, Jon Kroll Bjerregaard, Claus Wilki Fristrup, Per Pfeiffer, Michael Bau Mortensen
Background: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a laparoscopy-guided administration of aerosolized chemotherapy. PIPAC seems to improve objective tumor response, survival and quality of life in patients with peritoneal metastasis. We assessed feasibility and efficacy of PIPAC in patients with peritoneal metastasis (PM). Methods: Patients were included in a prospective PIPAC protocol. Patients with colorectal PM were treated with oxaliplatin, patients with other primary tumors were treated with cisplatin and doxorubicin...
2018: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/29896715/measurement-of-mitochondrial-toxicity-parameters-in-embryonic-hippocampus
#16
Ahmad Salimi, Jalal Pourahmad
Recent discoveries have focused on mitochondria functions in the neuroscience research for approaches to study mitochondria dysfunction in neurodegenerative diseases. Mitochondrion is one of the organelles that is possibly worst affected in cognitive impairments. These are known as "powerhouse" of the cell as they are the main source of generation of ATP through aerobic respiration. They have role in oxidative phosphorylation and metabolism, they play central role in cell differentiation, apoptosis, oxygen sensing and detoxification of reactive oxygen species, innate immunity, mitochondrial matrix calcium, and maintenance of cell quality and regulation of cytoplasmic...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29895707/comprehensive-safety-analysis-of-venetoclax-monotherapy-for-patients-with-relapsed-refractory-chronic-lymphocytic-leukemia
#17
Matthew S Davids, Michael Hallek, William Wierda, Andrew W Roberts, Stephan Stilgenbauer, Jeffrey A Jones, John F Gerecitano, Su Young Kim, Jalaja Potluri, Todd Busman, Andrea Best, Maria E Verdugo, Elisa Cerri, Monali Desai, Peter Hillmen, John F Seymour
PURPOSE: The oral BCL-2 inhibitor venetoclax is an effective therapy for patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL), including disease with high-risk genomic features such as chromosome 17p deletion (del[17p]) or progressive disease following B-cell receptor pathway inhibitors. EXPERIMENTAL DESIGN: We conducted a comprehensive analysis of the safety of 400mg daily venetoclax monotherapy in 350 patients with CLL using an integrated dataset from three phase-I/II studies...
June 12, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29893955/endoscopic-endonasal-focal-transclival-medial-condylectomy-approach-for-resection-of-a-foramen-magnum-meningioma-2-dimensional-operative-video
#18
Juan M Revuelta Barbero, Alaa S Montaser, Mostafa Shahein, André Beer-Furlan, Bradley A Otto, Ricardo L Carrau, Daniel M Prevedello
The endoscopic endonasal approach (EEA) provides direct access to foramen magnum meningiomas; however, it often requires extensive exposure including septal flap elevation with septum removal, complete sphenoidotomy, and panclivectomy.We present a case of a 54-yr-old-female with an incidental foramen magnum lesion followed up with serial imaging who presented 10 mo later with progressive neck discomfort and episodes of dizziness, with confirmed tumor progression and further brainstem compression. A focal transclival EEA with medial condylectomy was performed preserving the upper two-thirds of the clivus, the nasal septum, and the sphenoid sinus...
June 11, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29889818/effects-of-psychosocial-stress-on-subsequent-hemorrhagic-shock-and-resuscitation-in-male-mice
#19
Dominik Langgartner, Ulrich Wachter, Clair Hartmann, Michael Gröger, Josef Vogt, Tamara Merz, Oscar McCook, Marina Fink, Sandra Kress, Michael Georgieff, Julia F Kunze, Peter L Radermacher, Stefan O Reber, Martin Wepler
BACKGROUND: Hypoxemia and tissue ischemia during hemorrhage as well as formation of oxygen and nitrogen radicals during resuscitation promote hyperinflammation and, consequently, trigger severe multiple-organ-failure (MOF). Individuals diagnosed with stress-related disorders or reporting a life history of psychosocial stress are characterized by chronic low-grade inflammation and a reduced glucocorticoid (GC) signaling. We hypothesized that exposure to chronic psychosocial stress during adulthood prior to hemorrhagic shock increases oxidative/nitrosative stress and therefore the risk of developing MOF in mice...
June 8, 2018: Shock
https://www.readbyqxmd.com/read/29889275/myopericytoma-at-the-craniocervical-junction-clinicopathological-report-and-review-of-a-rare-perivascular-neoplasm
#20
Jimmy C Yang, Andrew S Venteicher, Matthew J Koch, Christopher J Stapleton, Gabriel N Friedman, Emma M Venteicher, John H Shin
BACKGROUND AND IMPORTANCE: Myopericytoma is an emerging class of neoplasm originating from the perivascular myoid cellular environment, previously classified as a variant of hemangiopericytoma. Most reported myopericytomas are found in soft tissues of the extremities; however, infrequent cases are described involving the central nervous system. Intracranial myopericytoma remains rare. Here, we describe the first report of myopericytoma occurring at the cervicomedullary junction in close proximity to the vertebral artery, mimicking a vascular lesion...
June 8, 2018: Neurosurgery
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