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https://www.readbyqxmd.com/read/28646325/anti-tuberculosis-bacteriophage-d29-delivery-with-a-vibrating-mesh-nebulizer-jet-nebulizer-and-soft-mist-inhaler
#1
Nicholas B Carrigy, Rachel Y Chang, Sharon S Y Leung, Melissa Harrison, Zaritza Petrova, Welkin H Pope, Graham F Hatfull, Warwick J Britton, Hak-Kim Chan, Dominic Sauvageau, Warren H Finlay, Reinhard Vehring
PURPOSE: To compare titer reduction and delivery rate of active anti-tuberculosis bacteriophage (phage) D29 with three inhalation devices. METHODS: Phage D29 lysate was amplified to a titer of 11.8 ± 0.3 log10(pfu/mL) and diluted 1:100 in isotonic saline. Filters captured the aerosolized saline D29 preparation emitted from three types of inhalation devices: 1) vibrating mesh nebulizer; 2) jet nebulizer; 3) soft mist inhaler. Full-plate plaque assays, performed in triplicate at multiple dilution levels with the surrogate host Mycobacterium smegmatis, were used to quantify phage titer...
June 23, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28618808/semi-analytical-modeling-of-ground-plate-interaction-for-general-elastic-boundary-conditions
#2
Loïc Grau, Bernard Laulagnet
This letter introduces ground/plate interaction using the concept of ground cross-modal impedance in the case of general elastic boundary conditions. Navier equations are generally used to account for ground vibration with two propagating waves, the dilatational wave and the shear wave. The plate equation of motion follows the Kirchhoff-Love hypothesis, where shear and rotational inertia are neglected in the plate thickness. The general elastic boundary conditions are expressed analytically through a two-dimensional Fourier series in the plate displacement solution...
June 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28605368/murine-short-axis-ventricular-heart-slices-for-electrophysiological-studies
#3
Gabriel Peinkofer, Juergen Hescheler, Marcel Halbach
Murine cardiomyocytes have been extensively used for in vitro studies of cardiac physiology and new therapeutic strategies. However, multicellular preparations of dissociated cardiomyocytes are not representative of the complex in vivo structure of cardiomyocytes, non-myocytes and extracellular matrix, which influences both mechanical and electrophysiological properties of the heart. Here we describe a technique to prepare viable ventricular slices of adult mouse hearts with a preserved in vivo like tissue structure, and demonstrate their suitability for electrophysiological recordings...
June 4, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28574408/effect-of-whole-body-vibration-training-on-quadriceps-strength-bone-mineral-density-and-functional-capacity-in-children-with-hemophilia-a-randomized-clinical-trial
#4
S El-Shamy
OBJECTIVES: The objective was to evaluate the effects of whole body vibration training on quadriceps strength, bone mineral density, and functional capacity in children with hemophilia. METHODS: Thirty children with hemophilia with age ranging from 9 to 13 years were selected and randomly assigned to either the study group that received whole body vibration training (30-40 Hz, 2-4 mm of peak-to-peak vertical plate displacement for 15 minutes/day, 3 days/week/ 12 weeks) plus the conventional physical therapy program or the control group that performed a conventional physical therapy program only...
June 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28531144/impact-damage-localisation-with-piezoelectric-sensors-under-operational-and-environmental-conditions
#5
Mohammad Saleh Salmanpour, Zahra Sharif Khodaei, M H Ferri Aliabadi
Guided-wave structural health monitoring (SHM) systems with piezoelectric sensors are investigated for localisation of barely visible impact damage in CFRP plates under vibration and different thermal conditions. A single baseline set is used in a delay-and-sum algorithm with temperature correction for damage localisation in a large temperature range. Damage localisation is also demonstrated under transient thermal conditions, with signals recorded while the temperature is rapidly decreased. Damage severity due to successive impact events is studied under constant temperature...
May 22, 2017: Sensors
https://www.readbyqxmd.com/read/28515484/the-complex-tibial-organ-of-the-new-zealand-ground-weta-sensory-adaptations-for-vibrational-signal-detection
#6
Johannes Strauß, Kathryn Lomas, Laurence H Field
In orthopteran insects, a complex tibial organ has evolved to detect substrate vibrations and/or airborne sound. Species of New Zealand weta (Anostostomatidae) with tympanal ears on the foreleg tibia use this organ to communicate by sound, while in atympanate species (which communicate by substrate drumming) the organ is unstudied. We investigated the complex tibial organ of the atympanate ground weta, Hemiandrus pallitarsis, for vibration detection adaptations. This system contains four sensory components (subgenual organ, intermediate organ, crista acustica homolog, accessory organ) in all legs, together with up to 90 scolopidial sensilla...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28509870/sound-power-estimation-for-beam-and-plate-structures-using-polyvinylidene-fluoride-films-as-sensors
#7
Qibo Mao, Haibing Zhong
The theory for calculation and/or measurement of sound power based on the classical velocity-based radiation mode (V-mode) approach is well established for planar structures. However, the current V-mode theory is limited in scope in that it can only be applied to conventional motion sensors (i.e., accelerometers). In this study, in order to estimate the sound power of vibrating beam and plate structure by using polyvinylidene fluoride (PVDF) films as sensors, a PVDF-based radiation mode (C-mode) approach concept is introduced to determine the sound power radiation from the output signals of PVDF films of the vibrating structure...
May 16, 2017: Sensors
https://www.readbyqxmd.com/read/28484335/coupling-strength-assumption-in-statistical-energy-analysis
#8
T Lafont, N Totaro, A Le Bot
This paper is a discussion of the hypothesis of weak coupling in statistical energy analysis (SEA). The examples of coupled oscillators and statistical ensembles of coupled plates excited by broadband random forces are discussed. In each case, a reference calculation is compared with the SEA calculation. First, it is shown that the main SEA relation, the coupling power proportionality, is always valid for two oscillators irrespective of the coupling strength. But the case of three subsystems, consisting of oscillators or ensembles of plates, indicates that the coupling power proportionality fails when the coupling is strong...
April 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28481501/high-throughput-investigation-of-a-lead-free-aln-based-piezoelectric-material-mg-hf-xal1-xn
#9
Hung H Nguyen, Hiroyuki Oguchi, Le Van Minh, Hiroki Kuwano
We conducted a high-throughput investigation of the fundamental properties of (Mg,Hf)xAl1-xN thin films (0 < x < 0.24) aiming for developing high-performance AlN-based piezoelectric materials. For the high-throughput investigation, we prepared composition-gradient (Mg,Hf)xAl1-xN films grown on a Si(100) substrate at 600 °C by cosputtering AlN and MgHf targets. To measure the properties of the various compositions at different positions within a single sample, we used characterization techniques with spatial resolution...
May 16, 2017: ACS Combinatorial Science
https://www.readbyqxmd.com/read/28469755/can-different-complex-training-improve-the-individual-phenomenon-of-post-activation-potentiation
#10
Zong-Rong Chen, Shin-Liang Lo, Min-Hsien Wang, Ching-Fang Yu, Hsien-Te Peng
The aims of the present study were (a) to determine whether the two types of complex training and vibration complex training would improve the individual phenomenon of post-activation potentiation (PAP) for every athlete in a team setting; and (b) to compare the acute effect of resistance and plyometric exercise, whole body vibration, complex training and vibration complex training on vertical jump performance. The participants were ten male division I college volleyball and basketball players. They were asked to perform three vertical jumps as a pre-test and were then randomly assigned to one of five PAP protocols, resistance exercise using half squat exercise, plyometric exercise using drop jumps with individualized drop height, whole body vibration using squats on a vibration plate, complex training combining resistance exercise with plyometric exercise, vibration complex training combining whole body vibration with plyometric exercise...
February 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28436860/effect-on-high-intensity-fields-of-a-tough-hydrophone-with-hydrothermal-pzt-thick-film-vibrator-and-titanium-front-layer
#11
Nagaya Okada, Shinichi Takeuchi
A novel tough hydrophone was fabricated by depositing hydrothermally synthesized lead zirconate titanate polycrystalline film on the back-side surface of a titanium plate. Our developed tough hydrophone resisted damage in a high-pressure field (15 MPa) at a focal point of a sinusoidal continuous wave driven by a concave high-intensity focused ultrasound (HIFU) transducer with up to 50 W of power input to the sound source. The hydrophone was suitable for the HIFU field, even though the hydrophone has a flat-shape tip of 3...
April 24, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28425516/mechanical-and-vibrational-characterization-of-amyloid-like-het-s-nanosheets-based-on-the-skewed-plate-theory
#12
Hyun Joon Chang, Myeongsang Lee, Jae In Kim, Gwonchan Yoon, Sungsoo Na
Pathological amyloidogenic prion proteins have a toxic effect on functional cells in the human cerebrum because of poor degradability and the tendency to accumulate in an uncontrolled manner under physiological conditions. HET-s, a fungal prion protein, is known to undergo conformational variations from fibrillar to nanosheet structures during a change from low to high pH conditions. It has been said that this conformational change can lead to self-propagation by nucleating on the lateral surface of singlet fibrils...
April 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28372094/vibration-damping-using-a-spiral-acoustic-black-hole
#13
Jae Yeon Lee, Wonju Jeon
This study starts with a simple question: can the vibration of plates or beams be efficiently reduced using a lightweight structure that occupies a small space? As an efficient technique to damp vibration, the concept of an acoustic black hole (ABH) is adopted with a simple modification of the geometry. The original shape of an ABH is a straight wedge-type profile with power-law thickness, with the reduction of vibration in beams or plates increasing as the length of the ABH increases. However, in real-world applications, there exists an upper bound of the length of an ABH due to space limitations...
March 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28367593/analytical-and-numerical-stability-analysis-of-soret-driven-convection-in-a-horizontal-porous-layer-the-effect-of-vertical-vibrations
#14
Soumaya Ouadhani, Ali Abdennadher, Abdelkader Mojtabi
The authors studied the effect of vertical high-frequency and small-amplitude vibrations on the separation of a binary mixture saturating a porous cavity. The horizontal bottom plate was submitted to constant uniform heat flux and the top one was maintained at constant temperature while no mass flux was imposed. The influence of vertical vibrations on the onset of convection and on the stability of the unicellular flow was investigated for positive separation ratio [Formula: see text]. The case of high-frequency and small-amplitude vibrations was considered so that a formulation using time averaged equations could be used...
April 2017: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/28336861/modified-continuum-mechanics-modeling-on-size-dependent-properties-of-piezoelectric-nanomaterials-a-review
#15
REVIEW
Zhi Yan, Liying Jiang
Piezoelectric nanomaterials (PNs) are attractive for applications including sensing, actuating, energy harvesting, among others in nano-electro-mechanical-systems (NEMS) because of their excellent electromechanical coupling, mechanical and physical properties. However, the properties of PNs do not coincide with their bulk counterparts and depend on the particular size. A large amount of efforts have been devoted to studying the size-dependent properties of PNs by using experimental characterization, atomistic simulation and continuum mechanics modeling with the consideration of the scale features of the nanomaterials...
January 26, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28253676/time-reversal-focusing-of-elastic-waves-in-plates-for-an-educational-demonstration
#16
Christopher Heaton, Brian E Anderson, Sarah M Young
The purpose of this research is to develop a visual demonstration of time reversal focusing of vibrations in a thin plate. Various plate materials are tested to provide optimal conditions for time reversal focusing. Specifically, the reverberation time in each plate and the vibration coupling efficiency from a shaker to the plate are quantified to illustrate why a given plate provides the best spatially confined focus as well as the highest focal amplitude possible. A single vibration speaker and a scanning laser Doppler vibrometer (SLDV) are used to provide the time reversal focusing...
February 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28252394/development-of-an-acoustic-levitation-linear-transportation-system-based-on-a-ring-type-structure
#17
Gilles P L Thomas, Marco A B Andrade, Julio Cezar Adamowski, Emilio Carlos Nelli Silva
A linear acoustic levitation transportation system based on a ring-type vibrator is presented. The system is composed by two 21-kHz Langevin transducers connected to a ring-shaped structure formed by two semicircular sections and two flat plates. In this system, a flexural standing wave is generated along the ring structure, producing an acoustic standing wave between the vibrating ring and a plane reflector located at a distance of approximately a half wavelength from the ring. The acoustic standing wave in air has a series of pressure nodes, where small particles can be levitated and transported...
May 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28249528/low-vibration-laboratory-with-a-single-stage-vibration-isolation-for-microscopy-applications
#18
Bert Voigtländer, Peter Coenen, Vasily Cherepanov, Peter Borgens, Thomas Duden, F Stefan Tautz
The construction and the vibrational performance of a low vibration laboratory for microscopy applications comprising a 100 ton floating foundation supported by passive pneumatic isolators (air springs), which rest themselves on a 200 ton solid base plate, are discussed. The optimization of the air spring system leads to a vibration level on the floating floor below that induced by an acceleration of 10 ng for most frequencies. Additional acoustic and electromagnetic isolation is accomplished by a room-in-room concept...
February 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28248509/young-s-equation-for-a-two-liquid-system-on-the-nanometer-scale
#19
J-C Fernandez-Toledano, T D Blake, J De Coninck
We use large-scale molecular dynamics simulations to study the Lennard-Jones forces acting at the various interfaces of a liquid bridge (liquid 1) between two realistic solid plates on the scale of few nanometers when the two free surfaces are in contact with a second immiscible liquid (liquid 2) with an interfacial tension of γ12. Each plate comprises a regular square planar lattice of atoms arranged in three atomic layers. To maintain rigidity while allowing momentum exchange with the liquid, solid atoms are allowed to vibrate thermally around their initial positions by a strong harmonic potential...
March 8, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28237824/damage-detection-of-fatigue-cracks-under-nonlinear-boundary-condition-using-subharmonic-resonance
#20
Mengyang Zhang, Li Xiao, Wenzhong Qu, Ye Lu
In recent years, the nonlinear ultrasonic technique has been widely utilized for detecting fatigue crack, one of the most common forms of damage. However, one of limitations associated with this technique is that nonlinearities can be produced not only by damage but also by various intrinsic effects such as boundary conditions. The objective of this paper is to demonstrate the application of a nonlinear ultrasonic subharmonic method for detecting fatigue cracks with nonlinear boundary conditions. The fatigue crack was qualitatively modeled as two elastic, frictionless half spaces that enter into contact during vibration and where the contact obeys the basic Hertz contact law...
May 2017: Ultrasonics
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