keyword
MENU ▼
Read by QxMD icon Read
search

Dement

keyword
https://www.readbyqxmd.com/read/29213490/neuropathological-findings-in-entorhinal-cortex-of-subjects-aged-50-years-or-older-and-their-correlation-with-dementia-in-a-sample-from-southern-brazil
#1
Edson Rodrigues Neto, Mariana K Fonseca, Álvaro C B Guedes, Francine H Oliveira, Arlete Hilbig, Liana Lisboa Fernandez
Introduction: The aims of this study were to survey neurodegenerative changes detected by abnormal protein deposits in the Entorhinal Cortex (EC) of subjects aged 50 years or older and to correlate these findings with suspected dementia, as detected by the IQCODE (Informant Questionnaire on Cognitive Decline in the Elderly). Methods: Fourteen brains were submitted to the immunohistochemistry technique for different proteins (beta-amyloid, tau, α-synuclein and phospho-TDP-43) and data obtained compared with IQCODE scores...
January 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29202376/circadian-rhythm-in-idiopathic-normal-pressure-hydrocephalus
#2
Andreas Eleftheriou, Martin Ulander, Fredrik Lundin
OBJECTIVES: The pathogenesis of idiopathic normal pressure hydrocephalus (iNPH) takes place in structures close to the cerebral ventricular system. Suprachiasmatic nucleus (SCN), situated close to the third ventricle, is involved in circadian rhythm. Diurnal disturbances are well-known in demented patients. The cognitive decline in iNPH is potentially reversible after a shunt operation. Diurnal rhythm has never been studied in iNPH. We hypothesize that there is a disturbance of circadian rhythm in iNPH-patients and the aim was to study any changes of the diurnal rhythm (mesor and circadian period) as well as any changes of the diurnal amplitude and acrophase of the activity in iNPH-patients before and after a shunt operation...
November 29, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29201282/the-impact-of-matching-functional-on-atrophy-measurement-from-geodesic-shooting-in-diffeomorphisms
#3
Greg M Fleishman, Paul M Thompson
Longitudinal registration has been used to map brain atrophy and tissue loss patterns over time, in both healthy and demented subjects. However, we have not seen a thorough application of the geodesic shooting in diffeomorphisms framework for this task. The registration model is complex and several choices must be made that may significantly impact the quality of results. One of these decisions is which image matching functional should drive the registration. We investigate four matching functionals for atrophy quantification using geodesic shooting in diffeomorphisms...
2017: Proceedings of the IEEE International Symposium on Biomedical Imaging: from Nano to Macro
https://www.readbyqxmd.com/read/29196815/amyloid-%C3%AE-oligomers-a%C3%AE-os-in-alzheimer-s-disease
#4
REVIEW
Barbara Mroczko, Magdalena Groblewska, Ala Litman-Zawadzka, Johannes Kornhuber, Piotr Lewczuk
The causative role of amyloid β 1-42 (Aβ42) aggregation in the pathogenesis of Alzheimer's disease (AD) has been under debate for over 25 years. Primarily, scientific efforts have focused on the dyshomeostasis between production and clearance of Aβ42. This imbalance may result from mutations either in genes for the substrate, i.e., amyloid precursor protein or in genes encoding presenilin, the enzyme of the reaction that generates Aβ42. Currently, it is supposed that soluble oligomers of amyloid beta (AβOs) and not fibrillar Aβ42 within neuritic plaques may be the toxic factors acting on a very early stage of AD, perhaps even initiating pathological cascade...
December 1, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29188855/ginkgo-biloba-extract-consumption-and-long-term-occurrence-of-death-and-dementia
#5
J F Dartigues, L Grasset, C Helmer, C Féart, L Letenneur, H Jacqmin-Gadda, P Joly, H Amieva
OBJECTIVES: To study the benefit of Ginkgo Biloba Extract (GBe) consumption on the long term risk of dementia and death in elderly people. DESIGN: The Paquid study is a population-based cohort with regular follow-up screenings up to twenty-two years and systematic detection of incident cases of dementia. Statistical analysis was conducted with an illness-death model dealing with interval censoring of dementia and competing risk of death. SETTING: The sample was randomly selected from electoral rolls in two administrative areas of southwestern France in 1988-1989...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29187812/adrenomedullin-contributes-to-age-related-memory-loss-in-mice-and-is-elevated-in-aging-human-brains
#6
Ignacio M Larrayoz, Hilda Ferrero, Eva Martisova, Francisco J Gil-Bea, María J Ramírez, Alfredo Martínez
Memory decline is common in elderly individuals and is the hallmark of Alzheimer's disease (AD). Memory failure follows the loss of synaptic contacts in the cerebral cortex and hippocampus, caused in part by cytoskeleton disruption. Adrenomedullin (AM) and its gene-related peptide, proadrenomedullin N-terminal 20 peptide (PAMP), are microtubule-associated proteins (MAP) whose expression has been identified as a potential biomarker for predicting progression from predementia to clinical AD. Here we analyze the connection between AM levels and memory preservation...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29186589/detergent-insoluble-proteins-and-inclusion-body-like-structures-immunoreactive-for-prkdc-dna-pk-dna-pkcs-ftl-nnt-and-aifm1-in-the-amygdala-of-cognitively-impaired-elderly-persons
#7
Jozsef Gal, Jing Chen, Yuriko Katsumata, David W Fardo, Wang-Xia Wang, Sergey Artiushin, Douglas Price, Sonya Anderson, Ela Patel, Haining Zhu, Peter T Nelson
Misfolded protein in the amygdala is a neuropathologic feature of Alzheimer disease and many other neurodegenerative disorders. We examined extracts from human amygdala (snap-frozen at autopsy) to investigate whether novel and as yet uncharacterized misfolded proteins would be detectable. Polypeptides from the detergent-insoluble, urea-soluble protein fractions of amygdala were interrogated using liquid chromatography-electrospray ionization-tandem mass spectrometry. Among the detergent-insoluble proteins identified in amygdala of demented subjects but not controls were Tau, TDP-43, Aβ, α-synuclein, and ApoE...
November 24, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29185023/sex-differences-in-the-association-of-alcohol-with-cognitive-decline-and-brain-pathology-in-a-cohort-of-octogenarians
#8
Casia Wardzala, Charles Murchison, Jennifer M Loftis, Katie J Schenning, Nora Mattek, Randall Woltjer, Jeff Kaye, Joseph F Quinn, Clare J Wilhelm
RATIONALE: The beneficial effects of moderate alcohol may differ in aging men versus women. OBJECTIVES: Cognitive and functional decline and neuropathology were investigated in a cohort of aging men and women with diverse alcohol histories. METHODS: Non-demented (Clinical Dementia Rating (CDR) of ≤ 0.5 and a Mini-Mental State Examination (MMSE) score of > 24), autonomously living participants were tracked in longitudinal aging studies to examine self-report and objective tests of rates of decline in a cohort (n = 486) of octogenarians...
November 29, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29175194/brain-signature-of-mild-stages-of-cognitive-and-behavioral-impairment-in-amyotrophic-lateral-sclerosis
#9
Lucas M T Branco, Thiago J R de Rezende, Caroline de O Roversi, Tamires Zanao, Raphael F Casseb, Brunno M de Campos, Marcondes C França
We aimed to assess the brain signature of cognitive and behavioral impairment in C9orf72-negative non-demented ALS patients. The study included 50 amyotrophic lateral sclerosis (ALS) patients (out of 75 initially recruited) and 38 healthy controls. High-resolution T1-weighted and spin-echo diffusion tensor images were acquired in a 3T MRI scanner. The multi atlas-based analysis protocol and the FreeSurfer tool were employed for gray matter assessment, and fiber tractography for white matter evaluation. Cognitively impaired ALS patients (n = 12) had bilateral amygdalae and left thalamic volumetric reduction compared to non-impaired ALS patients...
November 21, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29169563/historical-reflections-on-neurosyphilis-based-on-the-1826-treatise-on-general-paralysis-in-demented-patients-by-louis-florentin-calmeil-1798-1895
#10
REVIEW
F Macia, Y Ardagna
General paralysis is a neurological symptom of tertiary syphilis that was first identified in asylums as paralytic madness. The enlightened discussion of 60 clinicopathological cases provided by Louis Florentin Calmeil in his 1826 treatise greatly improved our knowledge of general paralysis. However, Calmeil was unable to relate this symptom to syphilis, although the latter was quite widespread at that time. Following a detailed reanalysis of Calmeil's observations with special attention to his clinical and demographic data, we conclude that this eminent clinician was unable to define the cause of general paralysis because his early 19th century mind was still under the influence of traditional knowledge and moral prejudices...
November 20, 2017: Revue Neurologique
https://www.readbyqxmd.com/read/29167045/long-term-caregiving-is-associated-with-impaired-cardiovagal-baroreflex
#11
Kevin K Wu, Taylor Bos, Brent T Mausbach, Milos Milic, Michael G Ziegler, Roland von Känel, Matthew A Allison, Joel E Dimsdale, Paul J Mills, Sonia Ancoli-Israel, Thomas L Patterson, Igor Grant
OBJECTIVE: Caregiving stress is associated with increased risk of cardiovascular disease (CVD). Inability to adequately regulate blood pressure is a possible underlying mechanism explaining this risk. We examined the relationship between length of caregiving and cardiovagal baroreflex sensitivity (cBRS) to better understand the link between caregiving and CVD risk. METHODS: A total of 146 elderly individuals (≥55years) participated in this study, of whom 96 were providing in-home care to a spouse with dementia and 50 were healthy controls married to a non-demented spouse (i...
December 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29162753/assessment-of-pain-in-the-elderly-a-literature-review
#12
REVIEW
Yoon-Sook Kim, Jae-Min Park, Yeon-Sil Moon, Seol-Heui Han
BACKGROUND: Pain perception is highly subjective, and effective pain management can be challenging in the elderly. We aimed to identify a set of practical measures that could be used to assess pain in elderly patients with or without cognitive impairment, as the first step towards effectively managing their pain. METHODS: We used the PRISMA guidelines for this literature review. Two reviewers independently assessed titles, abstracts and full-text articles, and a third reviewer resolved any disagreements...
July 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/29141280/subjective-cognitive-complaints-and-objective-cognitive-impairment-in-parkinson-s-disease
#13
Jin Yong Hong, Yoonju Lee, Mun Kyung Sunwoo, Young H Sohn, Phil Hyu Lee
BACKGROUND AND PURPOSE: Subjective cognitive complaints (SCCs) are very common in patients with Parkinson's disease (PD). However, the relationship between SCCs and objective cognitive impairment is still unclear. This study aimed to determine whether SCCs are correlated with objective cognitive performance in patients with PD. METHODS: Totals of 148 cognitively normal patients, 71 patients with mild cognitive impairment (MCI), and 31 demented patients were recruited consecutively from a movement-disorders clinic...
October 31, 2017: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29127552/mao-b-inhibitors-do-not-block-in-vivo-flortaucipir-18-f-av-1451-binding
#14
Allan K Hansen, David J Brooks, Per Borghammer
PURPOSE: Recent evidence suggests that the tau radiotracer [(18)F]THK-5351 displays high affinity for the monoamine oxidase type B (MAO-B) enzyme. Utilizing another tau-tracer, flortaucipir ([(18)F]AV-1451), we previously reported that non-demented Parkinson's disease patients show off-target binding in subcortical structures, but no appreciable cortical uptake. However, 59 % of these patients were receiving MAO-B inhibitors at the time of their scan. Here, we retrospectively investigated if MAO-B inhibitors in clinical doses affect flortaucipir binding...
November 10, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29124043/activities-of-daily-living-measured-by-the-harvard-automated-phone-task-track-with-cognitive-decline-over-time-in-non-demented-elderly
#15
Gad A Marshall, Sarah L Aghjayan, Maria Dekhtyar, Joseph J Locascio, Kamal Jethwani, Rebecca E Amariglio, Keith A Johnson, Reisa A Sperling, Dorene M Rentz
Background: Impairment in activities of daily living is a major burden to both patients and caregivers. Mild impairment in instrumental activities of daily living is often seen at the stage of mild cognitive impairment. The field of Alzheimer's disease is moving toward earlier diagnosis and intervention and more sensitive and ecologically valid assessments of instrumental or complex activities of daily living are needed. The Harvard Automated Phone Task, a novel performance-based activities of daily living instrument, has the potential to fill this gap...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29112517/use-of-antidementia-drugs-in-german-patients-with-alzheimer-s-disease
#16
Philipp Hessmann, Richard Dodel, Erika Baum, Matthias J Müller, Greta Paschke, Bernhard Kis, Jan Zeidler, Mike Klora, Jens-Peter Reese, Monika Balzer-Geldsetzer
The objective of this study was to evaluate the use of antidementia drugs (ADDs) in patients with Alzheimer's disease (AD) regarding German guideline recommendations and to assess correlations between the use of ADDs and the patients' characteristics. A total of 395 community-dwelling and institutionalized patients with AD across all severity stages of dementia were recruited in this cross-sectional study. Associations between the prescription of ADDs and patients' sociodemographic and clinical parameters (neuropsychiatric symptoms, cognitive capacity, daily activities, and health-related quality of life) were analyzed in multiple logistic regression analyses...
November 6, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29111133/in-vivo-brain-plaque-and-tangle-burden-mediates-the-association-between-diastolic-blood-pressure-and-cognitive-functioning-in-nondemented-adults
#17
Florence F Roussotte, Prabha Siddarth, David A Merrill, Katherine L Narr, Linda M Ercoli, Jacqueline Martinez, Natacha D Emerson, Jorge R Barrio, Gary W Small
OBJECTIVE: Growing evidence supports an association between increased blood pressure and: (a) poor cognitive performance in older adults, and (b) various biomarkers of increased Alzheimer's disease (AD) neuropathology. The objective of this study was to determine whether systolic blood pressure (SBP) and diastolic blood pressure (DBP) were significantly associated with cognitive functioning in non-demented adults, and to examine in vivo AD pathology as a possible mediator of this association...
September 15, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29106319/lesion-location-matters-the-relationships-between-white-matter-hyperintensities-on-cognition-in-the-healthy-elderly
#18
Leonie Lampe, Shahrzad Kharabian-Masouleh, Jana Kynast, Katrin Arelin, Christopher J Steele, Markus Löffler, A Veronica Witte, Matthias L Schroeter, Arno Villringer, Pierre-Louis Bazin
White matter hyperintensities (WMH) are associated with cognitive decline. We aimed to identify the spatial specificity of WMH impact on cognition in non-demented, healthy elderly. We quantified WMH volume among healthy participants of a community dwelling cohort ( n = 702, age range 60 - 82 years, mean age = 69.5 years, 46% female) and investigated the effects of WMH on cognition and behavior, specifically for executive function, memory, and motor speed performance. Lesion location influenced their effect on cognition and behavior: Frontal WMH in the proximity of the frontal ventricles mainly affected executive function and parieto-temporal WMH in the proximity of the posterior horns deteriorated memory, while WMH in the upper deep white matter-including the corticospinal tract-compromised motor speed performance...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29101848/human-fc-receptor-like-5-distinguishes-igg2-disulfide-isoforms-and-deamidated-charge-variants
#19
Oyeleye Alabi, Jessica Dement-Brown, Mate Tolnay
Human Fc receptor-like 5 (FCRL5) is a novel IgG receptor. We reported that IgG2 samples display a thousand-fold range affinity for FCRL5, indicating that attributes beyond the isotype affect binding. We hypothesized that the complex interaction could be exploited to identify distinct changes in the IgG2 molecule. We investigated using surface plasmon resonance two factors that might affect the interaction between IgG2 and FCRL5; heterogeneity related to disulfide isoforms and charge variants. We found that panitumumab and denosumab samples enriched for the more flexible A disulfide isoform bound FCRL5 with two-fold and 82-fold higher apparent affinity, respectively, than the B isoform...
November 1, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29094664/parkinson-s-disease-mild-cognitive-impairment-classifications-and-neurobehavioral-symptoms
#20
Kirstie L McDermott, Nancy Fisher, Sandra Bradford, Richard Camicioli
BACKGROUND: We apply recently recommended Parkinson's disease mild cognitive impairment (PD-MCI) classification criteria from the movement disorders society (MDS) to PD patients and controls and compare diagnoses to that of short global cognitive scales at baseline and over time. We also examine baseline prevalence of neuropsychiatric symptoms across different definitions of MCI. METHODS: 51 PD patients and 50 controls were classified as cognitively normal, MCI, or demented using MDS criteria (1...
November 2, 2017: International Psychogeriatrics
keyword
keyword
93791
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"