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MicroRNA and chronic pain

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https://www.readbyqxmd.com/read/27770129/microrna-16-alleviates-inflammatory-pain-by-targeting-ras-related-protein-23-rab23-and-inhibiting-p38-mapk-activation
#1
Wenjin Chen, Shengdong Guo, Shenggang Wang
BACKGROUND The purpose of our study was to determine the functional role of microRNA (miR)-16 in chronic inflammatory pain and to disclose its underlying molecular mechanism. MATERIAL AND METHODS Inflammatory pain was induced by injection of complete Freund's adjuvant (CFA) to Wistar rats. The pWPXL-miR-16, PcDNA3.1- Ras-related protein (RAB23), and/or SB203580 were delivered intrathecally to the rats. Behavioral tests were detected at 0 h, 4 h, 1 d, 4 d, 7 d, and 14 d after CFA injection. After behavioral tests, L4-L6 dorsal spinal cord were obtained and the levels of miR-16, RAB23, and phosphorylation of p38 (p-p38) were evaluated by quantitative real-time PCR (qRT-PCR)...
October 22, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27765894/microrna-30b-regulates-expression-of-the-sodium-channel-nav1-7-in-nerve-injury-induced-neuropathic-pain-in-the-rat
#2
Jinping Shao, Jing Cao, Jiannan Wang, Xiuhua Ren, Songxue Su, Ming Li, Zhihua Li, Qingzan Zhao, Weidong Zang
Voltage-gated sodium channels, which are involved in pain pathways, have emerged as major targets for therapeutic intervention in pain disorders. Nav1.7, the tetrodotoxin-sensitive voltage-gated sodium channel isoform encoded by SCN9A and predominantly expressed in pain-sensing neurons in the dorsal root ganglion, plays a crucial role in nociception. MicroRNAs are highly conserved, small non-coding RNAs. Through binding to the 3' untranslated region of their target mRNAs, microRNAs induce the cleavage and/or inhibition of protein translation...
2016: Molecular Pain
https://www.readbyqxmd.com/read/27697141/follicular-t-helper-cells-and-il-21-in-rheumatic-diseases
#3
Tue Kruse Rasmussen
Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are lifelong diseases with increased mortality and chronic pains. They are both characterized by immunological imbalances causing the immune system attack and destroy the bodies own tissues (called autoimmune disease). The best treatment, we are currently able to offer these patients, cause significant side-effects and can not prevent significant loss of quality of life. At the heart of the disease mechanisms in RA and SLE are subsets of immune cells called T and B cells...
October 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27690835/microrna-320a-predicts-chronic-axial-and-widespread-pain-development-following-motor-vehicle-collision-in-a-stress-dependent-manner
#4
Sarah D Linnstaedt, Kyle D Riker, Margaret G Walker, Jennifer E Nyland, Erin Zimny, Christopher Lewandowski, Phyllis L Hendry, Kathia Damiron, Claire Pearson, Marc-Anthony Velilla, Jeffrey Jones, Robert A Swor, Robert Domeier, Samuel A McLean
Study Design Prospective human cohort study combined with molecular studies. Background A microRNA is a small, noncoding RNA molecule that can play a role in disease onset. Recent studies found that circulating levels of microRNA 320a (miR-320a) are associated with musculoskeletal pain conditions and that miR-320a is stress responsive. Objectives To investigate whether circulating expression levels of miR-320a in the peritraumatic period predict persistent axial musculoskeletal pain 6 months after motor vehicle collision (MVC)...
October 2016: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/27599867/downregulation-of-mir-219-enhances-brain-derived-neurotrophic-factor-production-in-mouse-dorsal-root-ganglia-to-mediate-morphine-analgesic-tolerance-by-upregulating-camkii%C3%AE
#5
Xue-Ming Hu, Shou-Bin Cao, Hai-Long Zhang, Dong-Mei Lyu, Li-Ping Chen, Heng Xu, Zhi-Qiang Pan, Wen Shen
BACKGROUND: Increasing evidence suggests that microRNAs are functionally involved in the initiation and maintenance of pain hypersensitivity, including chronic morphine analgesic tolerance, through the posttranscriptional regulation of pain-related genes. We have previously demonstrated that miR-219 regulates inflammatory pain in the spinal cord by targeting calcium/calmodulin-dependent protein kinase II gamma (CaMKIIγ). However, whether miR-219 regulates CaMKIIγ expression in the dorsal root ganglia to mediate morphine tolerance remains unclear...
2016: Molecular Pain
https://www.readbyqxmd.com/read/27438293/on-the-prospect-of-clinical-utilization-of-micrornas-as-biomarkers-or-treatment-of-chronic-pain-a-comment-on-increased-mir-132-3p-expression-is-associated-with-chronic-neuropathic-pain
#6
Hjalte H Andersen, Kasper B Johnsen, Lars Arendt-Nielsen
No abstract text is available yet for this article.
July 17, 2016: Experimental Neurology
https://www.readbyqxmd.com/read/27429177/increased-cutaneous-mir-let-7d-expression-correlates-with-small-nerve-fiber-pathology-in-patients-with-fibromyalgia-syndrome
#7
Mathias Leinders, Kathrin Doppler, Thomas Klein, Maximiliane Deckart, Heike Rittner, Claudia Sommer, Nurcan Üçeyler
Fibromyalgia syndrome (FMS) is a chronic widespread pain condition probably comprising subgroups with different underlying pathomechanisms. There is increasing evidence for small nerve fiber impairment in subgroups of patients with FMS. MicroRNAs (miRNA) regulate molecular factors determining nerve de- and regeneration. We investigated whether systemic and cutaneous miRNA expression in FMS patients is related to small nerve fiber pathology. We confirmed previous findings of disturbed small fiber function and of reduced intraepidermal nerve fiber density in subgroups of patients with FMS...
July 15, 2016: Pain
https://www.readbyqxmd.com/read/27390915/expression-of-mirna-124a-in-cd4-cells-reflects-response-to-a-multidisciplinary-treatment-program-in-patients-with-chronic-low-back-pain
#8
Benjamin Luchting, Jens Heyn, Ludwig Christian Hinske, Shahnaz Christina Azad
STUDY DESIGN: Prospective evaluation of miRNA expression in patients with chronic low back pain (CLBP). OBJECTIVE: To evaluate whether pain and T cell related miRNAs are differentially expressed in CLBP when compared to healthy volunteers and whether these miRNAs may distinguish between responders and non-responders to a multidisciplinary treatment program. SUMMARY OF BACKGROUND DATA: CLBP is a common health problem worldwide. Multidisciplinary pain treatment programs have been proven as effective treatment option...
July 7, 2016: Spine
https://www.readbyqxmd.com/read/27349406/increased-mir-132-3p-expression-is-associated-with-chronic-neuropathic-pain
#9
M Leinders, N Üçeyler, R A Pritchard, C Sommer, L S Sorkin
Alterations in the neuro-immune balance play a major role in the pathophysiology of chronic neuropathic pain. MicroRNAs (miRNA) can regulate both immune and neuronal processes and may function as master switches in chronic pain development and maintenance. We set out to analyze the role of miR-132-3p, first in patients with peripheral neuropathies and second in an animal model of neuropathic pain. We initially determined miR-132-3p expression by measuring its levels in white blood cells (WBC) of 30 patients and 30 healthy controls and next in sural nerve biopsies of 81 patients with painful or painless inflammatory or non-inflammatory neuropathies based on clinical diagnosis...
September 2016: Experimental Neurology
https://www.readbyqxmd.com/read/27346077/microrna-1-associated-effects-of-neuron-specific-brain-derived-neurotrophic-factor-gene-deletion-in-dorsal-root-ganglia
#10
Elena Neumann, Timo Brandenburger, Sonia Santana-Varela, René Deenen, Karl Köhrer, Inge Bauer, Henning Hermanns, John N Wood, Jing Zhao, Robert Werdehausen
BACKGROUND: MicroRNAs (miRNAs) regulate gene expression in physiological as well as in pathological processes, including chronic pain. Whether deletion of a gene can affect expression of the miRNAs that associate with the deleted gene mRNA remains elusive. We investigated the effects of brain-derived neurotrophic factor (Bdnf) gene deletion on the expression of miR-1 in dorsal root ganglion (DRG) neurons and its pain-associated downstream targets heat shock protein 60 (Hsp60) and connexin 43 (Cx43) in tamoxifen-inducible conditional knockout mice, Bdnf(fl/fl); Advillin-CreER(T2) (Bdnf cKO)...
September 2016: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/27221957/editor-s-choice-biomarkers-of-acute-cardiovascular-and-pulmonary-diseases
#11
REVIEW
Toru Suzuki, Alexander Lyon, Rajeev Saggar, Liam M Heaney, Kenichi Aizawa, Antonio Cittadini, Ciro Mauro, Rodolfo Citro, Giuseppe Limongelli, Francesco Ferrara, Olga Vriz, Andrew Morley-Smith, Paolo Calabrò, Eduardo Bossone
Acute cardiothoracic and respiratory diseases frequently remain a challenge to diagnose and differentiate in the emergency setting. The main diseases that manifest with chest pain include ischaemic heart disease, myocarditis, acute pericarditis, aortic dissection/rupture and pulmonary embolism (PE). Diseases that primarily present with dyspnoea include heart failure (HF), acute respiratory distress syndrome (ARDS), pneumonia, asthma exacerbations and chronic obstructive pulmonary disease. Pre-test probabilities of clinical findings play a vital part in diagnostic decisions, and the use of a Bayesian approach to these greatly improves the ability to stratify patients more accurately...
September 2016: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/27132058/blood-biomarkers-for-the-non-invasive-diagnosis-of-endometriosis
#12
REVIEW
Vicki Nisenblat, Patrick M M Bossuyt, Rabia Shaikh, Cindy Farquhar, Vanessa Jordan, Carola S Scheffers, Ben Willem J Mol, Neil Johnson, M Louise Hull
BACKGROUND: About 10% of reproductive-aged women suffer from endometriosis, a costly chronic disease causing pelvic pain and subfertility. Laparoscopy is the gold standard diagnostic test for endometriosis, but is expensive and carries surgical risks. Currently, there are no non-invasive or minimally invasive tests available in clinical practice to accurately diagnose endometriosis. Although other reviews have assessed the ability of blood tests to diagnose endometriosis, this is the first review to use Cochrane methods, providing an update on the rapidly expanding literature in this field...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27059231/inhibition-of-microrna-221-alleviates-neuropathic-pain-through-targeting-suppressor-of-cytokine-signaling-1
#13
Li Xia, Yunlong Zhang, Tieli Dong
Neuropathic pain results in considerable trouble to people's physical and mental health. The pathophysiological mechanisms underlying its occurrence and development remain unclear. A large number of experiments show that microRNAs (miRNAs) play a major role in the pathogenesis of neuropathic pain and neuroinflammation resulting from nerve injury. Among various miRNAs, microRNA-221 (miR-221) overexpression has been reported in a chronic constrictive injury (CCI)-induced rat model of neuropathic pain. However, the role of miR-221 in the regulation of neuropathic pain is unknown...
July 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27047334/micrornas-are-involved-in-the-development-of-morphine-induced-analgesic-tolerance-and-regulate-functionally-relevant-changes-in-serpini1
#14
Jenica D Tapocik, Kristin Ceniccola, Cheryl L Mayo, Melanie L Schwandt, Matthew Solomon, Bi-Dar Wang, Truong V Luu, Jacqueline Olender, Thomas Harrigan, Thomas M Maynard, Greg I Elmer, Norman H Lee
Long-term opioid treatment results in reduced therapeutic efficacy and in turn leads to an increase in the dose required to produce equivalent pain relief and alleviate break-through or insurmountable pain. Altered gene expression is a likely means for inducing long-term neuroadaptations responsible for tolerance. Studies conducted by our laboratory (Tapocik et al., 2009) revealed a network of gene expression changes occurring in canonical pathways involved in neuroplasticity, and uncovered miRNA processing as a potential mechanism...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/26920008/microrna-based-biomarkers-in-pain
#15
REVIEW
Sujay Ramanathan, Seena K Ajit
Biomarkers are measurable characteristics reflective of the physiological or diseased state and a crucial feature in rendering personalized medicine more precise. Dysregulated expression of circulating microRNAs (miRNAs) in bodily fluids is being explored as noninvasive clinical biomarker for a variety of disorders including chronic pain. High-precision qPCR-based signal amplification of these miRNAs enables the detection of small changes making them ideal biomarker candidates. Presence of circulating miRNAs in exosomes, small vesicles that mediate intercellular communication, opens up novel avenues for target intervention and biomarker discovery...
2016: Advances in Pharmacology
https://www.readbyqxmd.com/read/26782075/downregulation-of-microrna-218-relieves-neuropathic-pain-by-regulating-suppressor-of-cytokine-signaling-3
#16
Longyun Li, Guoqing Zhao
Neuropathic pain is an incapacitating disease that affects a large number of people worldwide, but effective therapies have not yet been established. microRNAs (miRs) are short non-coding RNAs that participate in several biological processes and states, including neuropathic pain. Nevertheless, the precise role of miRs in regulating neuropathic pain remains largely unknown. In the present study, we investigated the role of miR-218 in neuropathic pain using a rat model of chronic constriction injury (CCI). miR-218 expression was induced and studied in the spinal cord and microglial cells of rats with CCI...
March 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/26663177/microrna-and-pain
#17
REVIEW
Atsushi Sakai, Hidenori Suzuki
Pain is an important protective system that alerts organisms to actual or possible tissue damage. However, a variety of pathologies can lead to chronic pain that is no longer beneficial. Lesions or diseases of the somatosensory nervous system cause intractable neuropathic pain that occasionally lasts even after the original pathology subsides. Chronic inflammatory diseases like arthritis are also associated with severe pain. Because conventional analgesics such as non-steroidal anti-inflammatory drugs and opioids have limited efficacy and/or severe adverse events associated with long-term use, chronic pain remains a major problem in clinical practice...
2015: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/26631964/microrna-24-inhibits-serotonin-reuptake-transporter-expression-and-aggravates-irritable-bowel-syndrome
#18
Xiu-Jun Liao, Wei-Ming Mao, Qin Wang, Guan-Gen Yang, Wen-Jing Wu, Shu-Xian Shao
Irritable bowel syndrome (IBS) is a common chronic functional gastrointestinal disorder. MicroRNAs (miRNAs) have been widely demonstrated to take part in various physiological and pathological processes. In the present study, the role of miR-24 in the pathogenesis of IBS and the potential mechanism in this process were evaluated. Human intestinal mucosa epithelial cells of colon from IBS patients and healthy subjects were collected. An IBS mouse model was established with the induction of trinitro-benzene-sulfonic acid (TNBS)...
January 8, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/26467071/emerging-role-of-microrna-in-neuropathic-pain
#19
Pu Jiangpan, Meng Qingsheng, Yang Zhiwen, Zhu Tao
BACKGROUND: Neuropathic pain is an incurable disease which is defined as a chronic pain caused by a disease or lesion of the nervous systems. Current treatments can provide a long-lasting pain relief only in a very limited number of patients with neuropathic pain. MicroRNA can regulate multiple genes and pathways involved in human diseases. This review focuses on: a) Molecular mechanisms of microRNA biogenesis. b) Targeting, modifications, and delivery of microRNAs. c) Aberrant expression of microRNAs and their potential therapeutic targets in neuropathic pain...
2016: Current Drug Metabolism
https://www.readbyqxmd.com/read/26448907/micrornas-downregulated-in-neuropathic-pain-regulate-mecp2-and-bdnf-related-to-pain-sensitivity
#20
Melissa T Manners, Yuzhen Tian, Zhaolan Zhou, Seena K Ajit
Nerve injury induces chronic pain and dysregulation of microRNAs in dorsal root ganglia (DRG). Several downregulated microRNAs are predicted to target Mecp2. MECP2 mutations cause Rett syndrome and these patients report decreased pain perception. We confirmed MeCP2 upregulation in DRG following nerve injury and repression of MeCP2 by miRNAs in vitro. MeCP2 regulates brain-derived neurotrophic factor (BDNF) and downregulation of MeCP2 by microRNAs decreased Bdnf in vitro. MeCP2 T158A mice exhibited reduced mechanical sensitivity and Mecp2-null and MeCP2 T158A mice have decreased Bdnf in DRG...
2015: FEBS Open Bio
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