Ariege Bizanti, Yuanyuan Zhang, Zulema Toledo, Kohlton T Bendowski, Scott W Harden, Anas Mistareehi, Jin Chen, David Gozal, Maci Heal, Richard Christie, Peter J Hunter, Julian F R Paton, Zixi Jack Cheng
Chronic intermittent hypoxia (CIH, a model for sleep apnoea) is a major risk factor for several cardiovascular diseases. Autonomic imbalance (sympathetic overactivity and parasympathetic withdrawal) has emerged as a causal contributor of CIH-induced cardiovascular disease. Previously, we showed that CIH remodels the parasympathetic pathway. However, whether CIH induces remodelling of the cardiac sympathetic innervation remains unknown. Mice (male, C57BL/6J, 2-3 months) were exposed to either room air (RA, 21% O2 ) or CIH (alternating 21% and 5...
December 29, 2023: Journal of Physiology