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Barbara J Morgan, Nicole Schrimpf, Morgan Rothman, Ann Mitzey, Mark S Brownfield, Robert C Speth, John M Dopp
Chronic intermittent hypoxia (CIH) increases basal sympathetic nervous system activity, augments chemoreflex-induced sympathoexcitation, and raises blood pressure. All effects are attenuated by systemic or intracerebroventricular administration of angiotensin II type 1 receptor (AT1 R) antagonists. This study aimed to quantify the effects of CIH on AT1 R- and AT2 R-like immunoreactivity in the rostroventrolateral medulla (RVLM) and paraventricular nucleus of the hypothalamus (PVN), central regions that are important components of the extended chemoreflex pathway...
March 21, 2018: Clinical and Experimental Hypertension: CHE
Fu-Chao Yu, Chu-Xiao Yuan, Jia-Yi Tong, Guang-Hao Zhang, Fang-Ping Zhou, Fang Yang
Intermittent hypoxia (IH) induced by obstructive sleep apnea (OSA) is the key factor in oxidative stress and the concomitant inflammation of endothelial cells (ECs). In recent years, the lipid sphingosine-1-phosphate (S1P) has been reported to probably play a central role in inflammatory diseases. However, its role in IH-induced endothelial injury remains uncertain. In this study, we investigated the IH-induced ECs inflammation and apoptosis, as well as the role of S1P in both. First, human umbilical vein endothelial cells (HUVECs) were treated with IH to explore the mechanism of S1P and S1P microbubbles (S1P-MBs) in HUVECs with altered function...
March 16, 2018: Biochemical and Biophysical Research Communications
Xiaofeng Zhang, Lijun Rui, Mei Wang, Hairong Lian, Liming Cai
BACKGROUND In the present study, we aimed to investigate the effects of sinomenine (SIN) on chronic intermittent hypoxia (CIH)- induced lung injury in rats, and to explore the underlying mechanisms. MATERIAL AND METHODS To perform the investigation, a CIH rat model was established. ELISA assay was applied to detect the level of inflammatory cytokines. Oxidative stress bio-markers (MDA, SOD, and CAT) were determined in lung tissues. In addition, the expression level of NADPH oxidase 2 (Nox2) was analyzed by Western blotting and qRT-PCR, respectively...
March 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Marlysa B Sullivan, Matt Erb, Laura Schmalzl, Steffany Moonaz, Jessica Noggle Taylor, Stephen W Porges
Yoga therapy is a newly emerging, self-regulating complementary and integrative healthcare (CIH) practice. It is growing in its professionalization, recognition and utilization with a demonstrated commitment to setting practice standards, educational and accreditation standards, and promoting research to support its efficacy for various populations and conditions. However, heterogeneity of practice, poor reporting standards, and lack of a broadly accepted understanding of the neurophysiological mechanisms involved in yoga therapy limits the structuring of testable hypotheses and clinical applications...
2018: Frontiers in Human Neuroscience
E Nicole Wilson, Marc Anderson, Brina Snyder, Phong Duong, Jenny Trieu, Derek A Schreihofer, Rebecca L Cunningham
Sleep apnea is a common sleep disorder characterized by intermittent periods of low blood oxygen levels. The risk for sleep apnea increases with age and is more prevalent in men than women. A common comorbidity of sleep apnea includes male sexual dysfunction, but it is not clear if a causal relationship exists between sleep apnea and sexual dysfunction. Possible mechanisms that link these two disorders include oxidative stress and testosterone. Oxidative stress is elevated in clinical patients with sleep apnea and in rodents exposed to chronic intermittent hypoxia (CIH), an animal model for apnea-induced hypopnea...
March 8, 2018: Physiology & Behavior
Huina Zhang, Fan Yang, Yichen Guo, Li Wang, Fang Fang, Hao Wu, Shaoping Nie, Yifan Wang, Man-Lung Fung, Yu Huang, Haiteng Deng, Yanwen Qin, Xinliang Ma, Yongxiang Wei
OBJECTIVE: Obstructive sleep apnea hypopnea syndrome (OSAHS) is an independent risk factor for many clinical complications. However, how OSAHS cause multiple organ injury and initiate inter-organ communication remains unclear. Moreover, despite it is well-recognized that chronic intermittent hypoxia (CIH) is a main feature of OSAHS, specific contribution of CIH to overall OSAHS-initiated pathological complications remains unclear. This study aimed to use an unbiased proteomic approach to determine whether OSAHS alters protein profiles of serum extracellular microvesicles (SEMVs) and how CIH contributes to such alterations...
March 6, 2018: Metabolism: Clinical and Experimental
Z-W Wen, D-S Liang, X-H Cai, J Chen
OBJECTIVE: To investigate the role of AMPK-mTOR signal pathway in brain injury induced by chronic intermittent hypoxia (CIH) in young rats. MATERIALS AND METHODS: Forty healthy male Sprague-Dawley rats (3-4 weeks old, weighing 80-100 g) were randomly assigned to four groups: 2-week-CIH group (2IH), 4-week-CIH group (4IH), 2-week-simulated air control group (2AC) and 4-week-simulated air control group (4AC). TUNEL staining was used to detect the cell apoptosis in the hippocampus and pre-frontal cortexes, respectively...
February 2018: European Review for Medical and Pharmacological Sciences
Yinglan Peng, Ke Hu
The present study investigated the effect of garlic (G) on serum, liver, renal and cerebral parameters of rats with chronic intermittent hypoxia (CIH) combined with diabetes mellitus (DM). A total of 32 rats were divided into eight groups, with 4 rats/group. A total of three models were established, including CIH, DM and CIH‑DM, and an additional healthy control (C) group. Rats in C‑G, CIH‑G, DM‑G and CIH‑DM‑G groups were injected with a G extract daily. Serum, liver, renal and cerebral parameters were detected...
February 7, 2018: Molecular Medicine Reports
David Monterde, Emili Vela, Montse Clèries, Luis García Eroles, Pol Pérez Sust
OBJECTIVE: To compare the performance in terms of goodness of fit and explanatory power of 2morbidity groupers in primary care (PC): adjusted morbidity groups (AMG) and clinical risk groups (CRG). DESIGN: Cross-sectional study. LOCATION: PC in the Catalan Institute for the Health (CIH), Catalonia, Spain. PARTICIPANTS: Population allocated in primary care centers of the CIH for the year 2014. MAIN MEASUREMENTS: Three indicators of interest are analyzed such as urgent hospitalization, number of visits and spending in pharmacy...
February 9, 2018: Atencion Primaria
Sara L Bober, John Ciriello, Douglas L Jones
Obstructive sleep apnea (OSA), which involves chronic, intermittent hypoxia (CIH), is a major risk factor for developing atrial fibrillation (AF). Whether or not CIH alone alters cardiac mechanisms to support AF is unknown. This study investigated the effects of CIH on atrial electrophysiology and arrhythmia vulnerability, and evaluated the role of autonomics in CIH promotion of AF. Adult male Sprague-Dawley rats were exposed to 8h/day of CIH or normoxia for 7 days. Following exposure, rats were anesthetized for intracardiac electrophysiological studies...
February 9, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Dongmei Song, Guoqiang Fang, Sun-Zhong Mao, Xiaobing Ye, Gang Liu, Edmund J Miller, Harly Greenberg, Shu Fang Liu
BACKGROUND AND AIMS: Chronic intermittent hypoxia (CIH) exposure causes atherosclerosis, although the underlying mechanisms are poorly understood. This study defines the role of endothelial intrinsic NF-κB signaling in the atherogenic response to CIH. METHODS: We created ApoE-ECI-κBmt mice that are deficient in the apolipoprotein E gene (ApoE-/-) and overexpress an I-κBα mutant (I-κBmt) selectively in endothelial cells. ApoE-/- and ApoE-ECI-κBmt mice were fed a normal chow diet (NCD) or high cholesterol diet (HCD) and exposed to sham or CIH, and atherosclerotic lesions were quantified...
January 30, 2018: Atherosclerosis
Wenjun Li, Kuan Hu, Qingzhou Zhang, Dongyuan Wang, Yue Ma, Zhanfeng Hou, Feng Yin, Zigang Li
The effects of N-methylation on CIH peptides' biophysical properties were systematically studied. N-Methylation at the N terminal NH could help improve the peptides' cellular uptake with a retained helical conformation. This N-methylation strategy could also be applied to longer peptides to improve their stability and cellular uptake.
February 1, 2018: Chemical Communications: Chem Comm
Weiding Wang, Kai Zhang, Xiongfeng Li, Zuowang Ma, Yue Zhang, Meng Yuan, Ya Suo, Xue Liang, Gary Tse, Christos A Goudis, Tong Liu, Guangping Li
INTRODUCTION: Atrial structural remodeling in the form of fibrosis contributes to the arrhythmic substrate in atrial fibrillation (AF). The aim of this study was to investigate the effects of doxycycline on chronic intermittent hypoxia (CIH)-induced atrial fibrosis and the pathophysiological mechanisms underlying such changes. METHODS: A total of 30 Sprague-Dawley rats were randomized into three groups: Control group, CIH group, CIH with doxycycline treatment (CIH-D) group...
January 29, 2018: Cardiovascular Therapeutics
Raphael R Perim, Mateus R Amorim, Leni G H Bonagamba, Benedito H Machado
Chronic intermittent hypoxia (CIH) and one-kidney one-clip (1K, 1C) experimental models lead to sympathetic overactivity and hypertension. We hypothesized that previous exposure to CIH potentiates the development of 1K, 1C renal hypertension. Male rats were divided into 4 groups: Control-1K, 1C, maintained under normoxia followed by 1K, 1C surgery (n = 19); Control-Sham, maintained under normoxia, followed by Sham surgery (n = 19); CIH-1K, 1C, exposed to CIH (10 days) and 1K, 1C surgery (n = 19); CIH-Sham, exposed to CIH and Sham surgery (n = 18)...
January 23, 2018: Experimental Physiology
Ling Chen, Zahra Heidari Zadi, Jin Zhang, Steven M Scharf, Eung-Kwon Pae
PURPOSE: Obstructive sleep apnea (OSA) is common in pregnancy, and may compromise fetal and even postnatal development. We developed an animal model to determine if maternal OSA could have lasting effects in offspring. METHODS: Pregnant Sprague Dawley rats were exposed to reduced ambient O2 from 21 to 4-5 %, approximately once/minute (chronic intermittent hypoxia - CIH) for 8 hours/day during gestation days 3-19. Similarly-handled animals exposed to ambient air served as controls (HC)...
December 14, 2017: Journal of Applied Physiology
Gavin Yamey, Lawrence H Summers, Dean T Jamison, Jessica Brinton
The Commission on Investing in Health (CIH), an international group of 25 economists and global health experts, published its Global Health 2035 report in The Lancet in December 2013. The report laid out an ambitious investment framework for achieving a "grand convergence" in health-a universal reduction in deaths from infectious diseases and maternal and child health conditions-within a generation. This article captures ten key elements that the CIH found important to its process and successful outcomes. The elements are presented in chronological order, from inception to post-publication activities...
January 10, 2018: Health Policy and Planning
Yuan-Chang Liang, Ya-Ru Lo, Chein-Chung Wang, Nian-Cih Xu
ZnO-ZnS core-shell nanorods are synthesized by combining the hydrothermal method and vacuum sputtering. The core-shell nanorods with variable ZnS shell thickness (7-46 nm) are synthesized by varying ZnS sputtering duration. Structural analyses demonstrated that the as-grown ZnS shell layers are well crystallized with preferring growth direction of ZnS (002). The sputtering-assisted synthesized ZnO-ZnS core-shell nanorods are in a wurtzite structure. Moreover, photoluminance spectral analysis indicated that the introduction of a ZnS shell layer improved the photoexcited electron and hole separation efficiency of the ZnO nanorods...
January 7, 2018: Materials
Seda Pehlivan, Ali Süner, Yasemin Yıldırım, Çiçek Fadıloğlu
The study was conducted to determine the levels of usage of complementary and integrative health (CIH) approaches and the symptoms experienced by Turkish patients with gastrointestinal cancer. A descriptive study was conducted on 81 patients with gastrointestinal cancer attending the medical oncology department of an oncology hospital. In the data collection stage, the patient description form that prepared by the researchers and the "Edmonton Symptom Assessment Scale" were used. Data were evaluated via Chi-square and student t test...
January 3, 2018: Journal of Religion and Health
Estelle B Gauda, Zankhana Master
Chronic intermittent hypoxia (CIH) occurs frequently in premature infants who have apnea of prematurity. Immaturity of the respiratory network from low central respiratory drive and the greater contribution of the carotid body on baseline breathing leads to respiratory instability in premature infants presenting as apnea and periodic breathing. During the 2nd week after birth, the smallest and the youngest premature infants have increased frequency of apnea and periodic breathing and associated oxygen desaturations that can persist for weeks after birth...
December 12, 2017: Respiratory Physiology & Neurobiology
Davi J A Moraes, Leni G H Bonagamba, Melina P da Silva, Julian F R Paton, Benedito H Machado
Sympathetic activity displays rhythmic oscillations generated by brainstem inspiratory and expiratory neurons. Amplification of these rhythmic respiratory-related oscillations is observed in rats under enhanced central respiratory drive or during development of neurogenic hypertension. Herein, we evaluated the involvement of ventral medullary sympatho-excitatory catecholaminergic C1 neurons, using inhibitory Drosophila allatostatin receptors, for the enhanced expiratory-related oscillations in sympathetic activity in rats submitted to chronic intermittent hypoxia (CIH) and following activation of both peripheral (hypoxia) and central chemoreceptors (hypercapnia)...
December 4, 2017: Scientific Reports
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