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https://www.readbyqxmd.com/read/28922718/tanshinone-iia-protects-against-chronic-intermittent-hypoxia-induced-myocardial-injury-via-activating-the-endothelin-1-pathway
#1
Na Wang, Yue Chang, Lingling Chen, Ya-Jing Guo, Ya-Shuo Zhao, Qiu-Hong Guo, En-Sheng Ji
Tanshinone IIA (Tan IIA) may exert significant protective effects against heart oxidative stress damage in obstructive sleep apnoea (OSA) syndrome. Chronic intermittent hypoxia (CIH)-triggered left ventricular dysfunction is used in a rat model to mimic CIH in OSA patients. 48 rats were randomly divided into three groups: normal control (NC) group, CIH group and CIH+Tan IIA group with 16 rats in each group. At the end of experiment (day 21), the blood pressure, Plasma ET-1 and NO content, hemodynamic indexes, heart histology, myocardial apoptosis as well as the expression of eNOS, ET-1, ETA receptor and ETB receptor were compared among different groups...
September 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28920441/new-insight-of-common-regulatory-pathways-in-human-trabecular-meshwork-cells-in-response-to-dexamethasone-and-prednisolone-using-an-integrated-quantitative-proteomics-swath-and-mrm-hr-mass-spectrometry
#2
Sze Wan Shan, Chi Wai Do, Thomas Chuen Lam, Ricky Pak Wing Kong, King Kit Li, Ka Man Chun, William Daniel Stamer, Chi Ho To
The molecular pathophysiology of corticosteroid-induced ocular hypertension (CIH) is not well understood. To determine the biological mechanisms of CIH, this study investigated protein expression profiles of human trabecular meshwork (hTM) cells in response to dexamethasone and prednisolone treatment. Both discovery-based Sequential Windowed data independent Acquisition of the Total High-resolution mass spectra (SWATH(TM)-MS) and targeted based high resolution multiple reaction monitoring (MRM-HR) confirmation were applied using a hybrid quadrupole-time-of-flight mass spectrometer...
September 18, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28904562/proceedings-from-the-cih-lmu-5th-infectious-diseases-symposium-2016-drug-resistant-tuberculosis-old-disease-new-challenge
#3
Celso Khosa, Krutarth Patel, Karlygash Abdiyeva, Nurkeldi Turebekov, Bettina Prüller, Norbert Heinrich
The 5th CIH(LMU) Infectious Disease Symposium, Munich, Germany, March 12, 2016 brought together Tuberculosis Experts from developed and low middle-income countries to discuss the control of drug resistance Tuberculosis. The meeting featured 9 presentations: Tuberculosis history and current scenario, Tuberculosis and migration - current scenario in Germany, Mechanism of Tuberculosis resistance development, Epidemiology of resistance - transmission vs. new generation of resistance, The impact of diagnostic in patients beyond - sensitivity and specificity, The Bangladesh regimen - new hope trough old drugs, New drugs and regimens - an overview on studies and Multi and Extensively Drug Resistant Tuberculosis from Europe...
2017: BMC Proceedings
https://www.readbyqxmd.com/read/28901388/inhibitory-effects-of-17%C3%AE-estradiol-or-a-resveratrol-dimer-on-hypoxia-inducible-factor-1%C3%AE-in-genioglossus-myoblasts-involvement-of-er%C3%AE-and-its-downstream-p38%C3%A2-mapk-pathways
#4
Yuanyuan Li, Yuehua Liu, Yun Lu, Bingjiao Zhao
Deficiency in the functioning of the genioglossus, which is one of the upper airway dilator muscles, is an important cause of obstructive sleep apnea/hypopnea syndrome (OSAHS). Estrogens have been reported to inhibit hypoxia-inducible factor-1α (HIF-1α) expression in hypoxia, regulating its target genes and exerting protective effects on the genioglossus in chronic intermittent hypoxia (CIH). This study aimed to investigate the role of 17β-estradiol (E2) and a resveratrol dimer (RD) on HIF-1α and the underlying mechanism...
September 7, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28900642/a-mutation-resistant-deoxyribozyme-or-gate-for-highly-selective-detection-of-viral-nucleic-acids
#5
Ola Kamar, Sin-Cih Sun, Chieh-Hua Lin, Wan-Yu Chung, Min-Shi Lee, Yu-Chieh Liao, Dmitry M Kolpashchikov, Min-Chieh Chuang
Highly selective probes hybridize only to fully complementary DNA or RNA sequences and, therefore, often fail to recognize mutated viral genomes. Here we designed a probe that possesses two seemingly incompatible properties: it tolerates some point mutations in genome, while it remains selective towards others. An OR deoxyribozyme logic gate was designed to fluorescently report the sequences of enterovirus 71 (EV71) covering ∼90% of all known EV71 strains. Importantly, sequences of closely related coxsackieviruses that differed by single nucleotides were reliably differentiated in 7 out of 8 cases...
September 13, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28893610/sex-differences-in-the-respiratory-sympathetic-coupling-in-rats-exposed-to-chronic-intermittent-hypoxia
#6
REVIEW
George Miguel P R Souza, Mateus R Amorim, Davi J A Moraes, Benedito H Machado
Obstructive sleep apnea (OSA) is a complex disease in which humans face episodes of intermittent hypoxia and it affects men and women. Patients with OSA present hypertension and sympathetic overactivity among several other dysfunctions. Therefore, one important question remains: are the autonomic dysfunctions associated with OSA similar in male and female? This is an unresolved question since sex factors are overlooked in most clinical and experimental studies. Epidemiological data indicate that sex exerts an important influence in the prevalence of OSA and associated comorbidities, such as hypertension...
September 8, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28892554/complementary-and-integrative-health-practices-for-depression
#7
Judy Haefner
The current article reviews selected complementary health approaches for the treatment of depressive symptoms. Complementary and integrative health (CIH) focuses on the whole person with the goal of optimal health-body, mind, and spirit. Patient use of integrative health practices and products is increasing; therefore, providers must understand these practices and products and be able to recommend or advise for or against their use based on research and guidelines. Difficulty with the current limitations of research on CIH practices is discussed, as these studies often may not have the same rigor or scientific weight as conventional treatment research...
September 11, 2017: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/28884757/an-in-tether-chiral-center-modulates-the-proapoptotic-activity-of-the-kla-peptide
#8
Jingxu Li, Kuan Hu, Hailing Chen, YuJie Wu, Longjian Chen, Feng Yin, Yuan Tian, Zigang Li
The helical peptide KLA (KLAKLAKKLAKLAK) is a well-known inducer of cellular apoptosis, acting to disrupt the mitochondrial membrane. However, its weak cellular uptake impedes development of any further applications. Here, we have utilized a novel in-tether chiral center induced helicity strategy (CIH) to develop a potent apoptosis inducer based on this KLA sequence. Notably, for the two resulting epimers of the CIH-KLA peptide, the CIH-KLA-(R) epimer exhibited superior cellular uptakes and special mitochondrial targeting when compared with its S counterpart...
September 8, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28882901/chronic-intermittent-hypoxia-impairs-insulin-sensitivity-but-improves-whole-body-glucose-tolerance-by-activating-skeletal-muscle-ampk
#9
Amandine Thomas, Elise Belaidi, Sophie Moulin, Sandrine Horman, Gerard C van der Zon, Benoit Viollet, Patrick Levy, Luc Bertrand, Jean-Louis Pepin, Diane Godin-Ribuot, Bruno Guigas
Obstructive sleep apnea syndrome is a highly prevalent disease resulting in transient respiratory arrest and chronic intermittent hypoxia (cIH). cIH is associated with insulin resistance and impaired metabolic homeostasis in both rodents and humans but the exact underlying mechanism(s) remains unclear. In the present study, we investigated the effects of two weeks of cIH (1min cycle, FiO2 21-5%, 8h/day) on whole-body insulin sensitivity and glucose tolerance in lean mice. Although food intake and body weight were reduced when compared to normoxia, cIH induced systemic insulin resistance in a hypoxia-inducible factor-1α-independent manner and impaired insulin signaling in liver, white adipose tissue and skeletal muscle...
September 7, 2017: Diabetes
https://www.readbyqxmd.com/read/28878129/correction-of-intermittent-hypoxia-reduces-inflammation-in-obese-subjects-with-obstructive-sleep-apnea
#10
Sebastio Perrini, Angelo Cignarelli, Vitaliano Nicola Quaranta, Vito Antonio Falcone, Stella Kounaki, Stefania Porro, Alessandro Ciavarella, Romina Ficarella, Maria Barbaro, Valentina Annamaria Genchi, Pasquale Nigro, Pierluigi Carratù, Annalisa Natalicchio, Luigi Laviola, Onofrio Resta, Francesco Giorgino
BACKGROUND: In obese subjects with obstructive sleep apnea (OSA), chronic intermittent hypoxia (CIH) may be linked to systemic and adipose tissue inflammation. METHODS: We obtained abdominal subcutaneous adipose tissue biopsies from OSA and non-OSA obese (BMI > 35) subjects at baseline and after 24 weeks (T1) of weight-loss intervention plus continuous positive airway pressure (c-PAP) or weight-loss intervention alone, respectively. OSA subjects were grouped according to good (therapeutic) or poor (subtherapeutic) adherence to c-PAP...
September 7, 2017: JCI Insight
https://www.readbyqxmd.com/read/28865137/high-performance-novel-cspb1-xsnxbr3-perovskite-quantum-dots-for-highly-efficient-light-emitting-diodes
#11
Hung-Chia Wang, Weigao Wang, An-Cih Tang, Hsin-Yu Tsai, Zhen Bao, Toshiyuki Ihara, Naoki Yarita, Hirokazu Tahara, Yoshihiko Kanemitsu, Shuming Chen, Ru-Shi Liu
All inorganic CsPbBr3 perovskite quantum dots (QDs) are potential emitters for electroluminescent display. We demonstrated an easy hot-injection method to partially replace the toxic Pb2+ with the highly stable Sn4+. Meanwhile, the absolute photoluminescence (PL) quantum yield of CsPb1-xSnxBr3 with Sn(IV) substitution increased from 45% to 83%. Based on femtosecond transient-absorption (TA), time-resolved PL, and single-dot spectroscopies, TA dynamics in undoped CsPbBr3 and CsPb0.67Sn0.33Br3 QDs at various excitation fluences...
September 2, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28835062/-effects-of-chronic-intermittent-hypoxia-on-left-ventricular-myocardial-contractibility-in-a-rabbit-model-of-obstructive-sleep-apnea
#12
L F Xu, Y F Cai, K Hu, S Tang, X F Zhou, H M Li
Objective: To explore the effects of chronic intermittent hypoxia (CIH) on left ventricular myocardial contractibility in a rabbit model of obstructive sleep apnea (OSA). Methods: Based on random number table, twenty-four rabbits were randomly divided into three groups: operation, sham, and control groups, each with 8 rabbits. The rabbit model for OSA in operation group was established by repeatedly closing the airway and then reopening it. Upper airway obstructions were conducted on rabbits every day, which were alternately closed for 15 s and then reopened for 75 s in a 90 s-long cycle, for 8 h each day over 3 months...
August 22, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28827830/treatment-effects-between-monotherapy-of-donepezil-versus-combination-with-memantine-for-alzheimer-disease-a-meta-analysis
#13
Ruey Chen, Pi-Tuan Chan, Hsin Chu, Yu-Cih Lin, Pi-Chen Chang, Chien-Yu Chen, Kuei-Ru Chou
BACKGROUND: This is the first meta-analysis to compare the treatment effects and safety of administering donepezil alone versus a combination of memantine and donepezil to treat patients with moderate to severe Alzheimer Disease, particularly regarding cognitive functions, behavioral and psychological symptoms in dementia (BPSD), and global functions. METHODS: PubMed, Medline, Embase, PsycINFO, and Cochrane databases were used to search for English and non-English articles for inclusion in the meta-analysis to evaluate the effect size and incidence of adverse drug reactions of different treatments...
2017: PloS One
https://www.readbyqxmd.com/read/28822761/down-regulation-of-vascular-ppar-%C3%AE-contributes-to-endothelial-dysfunction-in-high-fat-diet-induced-obese-mice-exposed-to-chronic-intermittent-hypoxia
#14
Yanan Zhang, Chunlian Zhang, Haiou Li, Jingdong Hou
Obstructive sleep apnea (OSA), characterized by chronic intermittent hypoxia (CIH), is associated with endothelial dysfunction. The prevalence of OSA is linked to an epidemic of obesity. CIH has recently been reported to cause endothelial dysfunction in diet-induced obese animals by exaggerating oxidative stress and inflammation, but the underlying mechanism remains unclear. PPAR-γ, a ligand-inducible transcription factor that exerts anti-oxidant and anti-inflammatory effects, is down-regulated in the peripheral tissues in diet-induce obesity...
October 14, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28819392/long-term-trends-in-primary-sites-of-gastric-adenocarcinoma-in-japan-and-the-united-states
#15
Michitaka Honda, Sandra L Wong, Mark A Healy, Toshifusa Nakajima, Masayuki Watanabe, Shingo Fukuma, Shunichi Fukuhara, John Z Ayanian
Background: The incidence and characteristics of gastric cancer have been shown to vary widely across Western and Eastern countries. Our study had two aims: to evaluate long-term trends in gastric adenocarcinoma in Japan over a period of 70 years, and to anticipate the future of gastric cancer in Japan, through comparison with data from the United States. Methods: Japanese patient data for 19,306 incident cases of gastric adenocarcinoma from 1946 - 2014 were collected from the Gastric Cancer Database at the Cancer Institute Hospital, Tokyo, Japan (CIH-GCDB)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28780538/optimal-dose-of-succinylcholine-for-laryngeal-mask-airway-insertion-systematic-review-meta-analysis-and-metaregression-of-randomised-control-trials
#16
Alan Hsi-Wen Liao, Yu-Cih Lin, Chyi-Huey Bai, Chien-Yu Chen
OBJECTIVES: To evaluate the optimal dose of succinylcholine for laryngeal mask airway (LMA) insertion and all related morbidities. DESIGN: Systematic review, meta-analysis and metaregression of randomised controlled trials (RCTs). DATA SOURCE AND STUDY ELIGIBILITY CRITERIA: A comprehensive search of RCTs in the PubMed, Embase, the Cochrane Library and the ClinicalTrials.gov registry up to July 2016 and articles that evaluated the use of succinylcholine chloride for LMA insertion were included in the analyses...
August 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28773138/fabrication-of-nanosized-island-like-cdo-crystallites-decorated-tio%C3%A2-rod-nanocomposites-via-a-combinational-methodology-and-their-low-concentration-no%C3%A2-gas-sensing-behavior
#17
Yuan-Chang Liang, Nian-Cih Xu, Chein-Chung Wang, Da-Hua Wei
TiO₂-CdO composite rods were synthesized through a hydrothermal method and sputtering thin-film deposition. The hydrothermally derived TiO₂ rods exhibited a rectangular cross-sectional crystal feature with a smooth surface, and the as-synthesized CdO thin film exhibited a rounded granular surface feature. Structural analyses revealed that the CdO thin film sputtered onto the surfaces of the TiO₂ rods formed a discontinuous shell layer comprising many island-like CdO crystallites. The TiO₂-CdO composite rods were highly crystalline, and their surfaces were rugged...
July 10, 2017: Materials
https://www.readbyqxmd.com/read/28751002/laparoscopic-pediatric-inguinal-hernia-repair-a-controlled-randomized-study
#18
Mohamed Abd-Alrazek, Hatem Alsherbiny, Mohamad Mahfouz, Omar Alsamahy, Rafik Shalaby, Abdelmoniem Shams, Ahmed Elian, Yasser Ashour
BACKGROUND: Inguinal hernia repair is one of the most frequently performed surgical procedures in infants and young children. Laparoscopic hernia repair in infancy and childhood is still debatable. There are many techniques available for laparoscopic hernia repair in pediatrics. The aim of the study is to compare laparoscopic intracorporeal purse-string suture ligation of the hernia defect leaving the sac intact versus disconnection of the hernia sac with intracorporeal suture of proximal part...
July 13, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28749702/what-patients-and-providers-want-to-know-about-complementary-and-integrative-health-therapies
#19
Stephanie L Taylor, Karleen F Giannitrapani, Anita Yuan, Nell Marshall
OBJECTIVES: We conducted a quality improvement project to determine (1) what information providers and patients most wanted to learn about complementary and integrative health (CIH) therapies and (2) in what format they wanted to receive this information. The overall aim was to develop educational materials to facilitate the CIH therapy decision-making processes. DESIGN: We used mixed methods to iteratively pilot test and revise provider and patient educational materials on yoga and meditation...
July 27, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28670393/chronic-intermittent-hypoxia-decreases-pulmonary-clearance-of-99m-tc-labelled-particulate-matter-in-mice
#20
Cuiping Fu, Huan Lu, Xu Wu, Jie Liu, Chengying Liu, Zilong Liu, Wei Yuan, Jian Zhou, Shanqun Li
BACKGROUND: Obstructive sleep apnea-hypopnea syndrome (OSAHS) could cause systematic inflammation including pulmonary inflammatory response, whereas the influence of OSAHS in pulmonary clearance ability remains unknown. The main pathophysiological feature of OSAHS is chronic intermittent hypoxia (CIH). The goal of this study is to clarify the airway clearance of particulate matter (PM) in CIH mice, and to explore the potential mechanism. METHODS: Balb/c mice were divided into a CIH group and a control group, exposed to intermittent hypoxia and air chamber, respectively...
2017: American Journal of Translational Research
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