keyword
MENU ▼
Read by QxMD icon Read
search

Cih

keyword
https://www.readbyqxmd.com/read/27929189/switching-substitution-groups-on-the-in-tether-chiral-centre-influences-backbone-peptides-permeability-and-target-binding-affinity
#1
Yixiang Jiang, Kuan Hu, Xiaodong Shi, Qingzhuang Tang, ZiChen Wang, Xiyang Ye, Zigang Li
Different substitution groups on the in-tether chiral centre of chirality-induced helical peptides (CIH peptides) showed distinguishable effects on the peptides' cellular uptakes and binding affinities with the estrogen receptor α(ER-α). This study proves that in-tether chiral centres are a valuable modification site for constructing peptide ligands with preferable biophysical properties.
December 8, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27925776/providers-and-administrators-perceptions-of-complementary-and-integrative-health-practices-across-the-veterans-health-administration
#2
Carol E Fletcher, Allison R Mitchinson, Erika Trumble, Daniel B Hinshaw, Jeffery A Dusek
OBJECTIVES: Use of complementary and integrative health (CIH) therapies is being promoted by the Veterans Health Administration (VA), but promotion may not equate to adoption. The purpose of this study was to explore whether perceptions regarding CIH at one VA medical center (VAMC) were similar to perceptions from a sample of other VAMCs. DESIGN: This article reports a subset of qualitative findings from a mixed-methods study. SETTING/PARTICIPANTS: Sites were recruited through a VA-wide CIH listserver...
December 7, 2016: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/27916083/-effects-of-chronic-intermittent-hypoxia-on-hepatic-function-and-protective-mechanism-of-adiponectin-in-rats
#3
R Xue, J Cao, X L Zhang, W X Ding, W J Wang, H P Huang
Objective: To explore the effect of chronic intermittent hypoxia (CIH) on rats hepatic function, and the protective mechanism of adiponectin (Ad). Methods: Sixty healthy male wistar rats were randomly divided into 4 groups: normal control (NC), NC+ Ad, CIH, and CIH+ Ad groups with 15 rats in each. The rats in CIH and CIH+ Ad groups were exposed to an intermittent hypoxic chamber 8 hours per day for 4 months. Meanwhile, the rats in both the NC and NC + Ad groups were housed with normal pressure air. The rats in the NC+ Ad and CIH+ Ad groups were additionally treated with an intravenous injection of Ad (10 μg), twice a week for 4 months...
November 29, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27884793/sex-stress-and-sleep-apnoea-decreased-susceptibility-to-upper-airway-muscle-dysfunction-following-intermittent-hypoxia-in-females
#4
REVIEW
Ken D O'Halloran, Philip Lewis, Fiona McDonald
Obstructive sleep apnoea syndrome (OSAS) is a devastating respiratory control disorder more common in men than women. The reasons for the sex difference in prevalence are multifactorial, but are partly attributable to protective effects of oestrogen. Indeed, OSAS prevalence increases in post-menopausal women. OSAS is characterized by repeated occlusions of the pharyngeal airway during sleep. Dysfunction of the upper airway muscles controlling airway calibre and collapsibility is implicated in the pathophysiology of OSAS, and sex differences in the neuro-mechanical control of upper airway patency are described...
November 21, 2016: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/27871302/glycopyrrolate-in-comparison-to-hyoscine-hydrobromide-and-placebo-in-the-treatment-of-hypersalivation-induced-by-clozapine-gothic1-study-protocol-for-a-randomised-controlled-feasibility-study
#5
Inti Qurashi, Simon Chu, Nusrat Husain, Richard J Drake, Imran Chaudhry, J F W Deakin
BACKGROUND: Clozapine is the only medication licensed for the treatment of resistant schizophrenia in the UK. Although efficacious, a common and unpopular side effect of clozapine treatment is clozapine-induced hypersalivation (CIH), which can contribute to non-adherence. The standard treatment for CIH in the UK is hyoscine hydrobromide but this may aggravate cognitive deficits in patients with schizophrenia while glycopyrrolate may be an effective alternative with a more tolerable side effect profile...
November 21, 2016: Trials
https://www.readbyqxmd.com/read/27849271/quality-of-hospital-databases-in-brazil-some-elements
#6
Juliana Pires Machado, Mônica Martins, Iuri da Costa Leite
Introduction: The use of secondary data for health service research has been increasingly common, having the advantage of acquiring information faster and cheaper, in addition to its larger population, temporal and geographical amplitude. Objectives: The aim of this study was to describe problems in the quality of information about hospitals characteristics and hospitalizations in Brazil. Methods: The National Database on Health Units (CNES), the Public Hospital Information System (SIH), and the Private Hospital Information System (CIH) were analyzed...
July 2016: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/27775047/repetitive-electroacupuncture-attenuates-cold-induced-hypertension-through-enkephalin-in-the-rostral-ventral-lateral-medulla
#7
Min Li, Stephanie C Tjen-A-Looi, Zhi-Ling Guo, John C Longhurst
Acupuncture lowers blood pressure (BP) in hypertension, but mechanisms underlying its action are unclear. To simulate clinical studies, we performed electroacupuncture (EA) in unanesthetized rats with cold-induced hypertension (CIH) induced by six weeks of cold exposure (6 °C). EA (0.1 - 0.4 mA, 2 Hz) was applied at ST36-37 acupoints overlying the deep peroneal nerve for 30 min twice weekly for five weeks while sham-EA was conducted with the same procedures as EA except for no electrical stimulation...
October 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27748200/statins-may-prevent-atherosclerotic-disease-in-osa-patients-without-co-morbidities
#8
Domenico Maurizio Toraldo, Michele De Benedetto, Luana Conte, Francesco De Nuccio
Obstructive sleep apnea (OSA) is characterized by repetitive interruptions of breathing, causing a Chronic Intermittent Hypoxia (CIH) that can be a key step in the development and progression of cardiovascular diseases. Nowadays, in fact, there is scientific evidence showing the close relationship between OSA and atherosclerosis, even in those patients who do not show co-morbidities such as hypertension, diabetes, high levels of low-density lipoprotein (LDL), cigarette smoking and obesity, which normally are able to activate the endothelium...
October 7, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27736201/aav-delivery-of-endothelin-1-shrna-attenuates-cold-induced-hypertension
#9
Peter Gin-Fu Chen, Zhongjie Sun
Cold temperatures are associated with increased prevalence of hypertension. Cold exposure increases endothelin-1 (ET1) production. The purpose of this study is to determine if upregulation of ET1 contributes to cold-induced hypertension (CIH). In vivo RNAi silencing of the ET1 gene was achieved by AAV2 delivery of ET1 short-hairpin siRNA (ET1-shRNA). Four groups of male rats were used. Three groups were given AAV.ET1-shRNA, AAV.SC-shRNA (scrambled shRNA), and phosphate-buffered saline (PBS), respectively, before exposure to a moderately cold environment (6...
October 12, 2016: Human Gene Therapy
https://www.readbyqxmd.com/read/27713705/pacemaking-property-of-rvlm-presympathetic-neurons
#10
Daniela Accorsi-Mendonça, Melina P da Silva, George M P R Souza, Ludmila Lima-Silveira, Marlusa Karlen-Amarante, Mateus R Amorim, Carlos E L Almado, Davi J A Moraes, Benedito H Machado
Despite several studies describing the electrophysiological properties of RVLM presympathetic neurons, there is no consensus in the literature about their pacemaking property, mainly due to different experimental approaches used for recordings of neuronal intrinsic properties. In this review we are presenting a historical retrospective about the pioneering studies and their controversies on the intrinsic electrophysiological property of auto-depolarization of these cells in conjunction with recent studies from our laboratory documenting that RVLM presympathetic neurons present pacemaking capacity...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27698713/c1-inhibitor-mediated-myocardial-protection-from-chronic-intermittent-hypoxia-induced-injury
#11
Jinrong Fu, Furong Guo, Cheng Chen, Xiaoman Yu, Ke Hu, Mingjiang Li
The optimal treatment for chronic intermittent hypoxia (CIH)-induced cardiovascular injuries has yet to be determined. The aim of the current study was to explore the potential protective effect and mechanism of a C1 inhibitor in CIH in the myocardium. The present study used a rat model of CIH in which complement regulatory protein, known as C1 inhibitor (C1INH), was administered to the rats in the intervention groups. Cardiomyocyte apoptosis was detected by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27688824/soluble-receptor-for-advanced-glycation-end-product-ameliorates-chronic-intermittent-hypoxia-induced-renal-injury-inflammation-and-apoptosis-via-p38-jnk-signaling-pathways
#12
Xu Wu, Wenyu Gu, Huan Lu, Chengying Liu, Biyun Yu, Hui Xu, Yaodong Tang, Shanqun Li, Jian Zhou, Chuan Shao
Obstructive sleep apnea (OSA) associated chronic kidney disease is mainly caused by chronic intermittent hypoxia (CIH) triggered tissue damage. Receptor for advanced glycation end product (RAGE) and its ligand high mobility group box 1 (HMGB1) are expressed on renal cells and mediate inflammatory responses in OSA-related diseases. To determine their roles in CIH-induced renal injury, soluble RAGE (sRAGE), the RAGE neutralizing antibody, was intravenously administered in a CIH model. We also evaluated the effect of sRAGE on inflammation and apoptosis...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27686454/chronic-intermittent-hypoxia-affects-the-cytosolic-phospholipase-a2%C3%AE-cyclooxygenase-2-pathway-via-%C3%AE-2-adrenoceptor-mediated-erk-p38-stimulation
#13
Petra Micova, Klara Hahnova, Marketa Hlavackova, Barbara Elsnicova, Anna Chytilova, Kristyna Holzerova, Jitka Zurmanova, Jan Neckar, Frantisek Kolar, Olga Novakova, Jiri Novotny
Cardiac resistance against acute ischemia/reperfusion (I/R) injury can be enhanced by adaptation to chronic intermittent hypoxia (CIH), but the changes at the molecular level associated with this adaptation are still not fully explored. Phospholipase A2 (PLA2) plays an important role in phospholipid metabolism and may contribute to membrane destruction under conditions of energy deprivation during I/R. The aim of this study was to determine the effect of CIH (7000 m, 8 h/day, 5 weeks) on the expression of cytosolic PLA2α (cPLA2α) and its phosphorylated form (p-cPLA2α), as well as other related signaling proteins in the left ventricular myocardium of adult male Wistar rats...
September 30, 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27678302/adiponectin-protects-the-rats-liver-against-chronic-intermittent-hypoxia-induced-injury-through-amp-activated-protein-kinase-pathway
#14
Wenxiao Ding, Qiang Zhang, Yanbin Dong, Ning Ding, Hanpeng Huang, Xianji Zhu, Sean Hutchinson, Xingya Gao, Xilong Zhang
This study was performed to assess the effect of chronic intermittent hypoxia (CIH) on the liver, the associated mechanisms and the potential therapeutic roles of adiponectin (Ad). Sixty rats were randomly assigned to four groups: the normal control (NC), NC and Ad supplement (NC + Ad), CIH, and CIH and Ad supplement (CIH + Ad) groups. The rats in the CIH and CIH + Ad groups were exposed to a hypoxic environment for 4 months. Rats in the NC + Ad and CIH + Ad groups were also treated with an intravenous injection of Ad (10 ug), twice a week...
September 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27635524/inflammatory-events-and-oxidant-production-in-the-diaphragm-gastrocnemius-and-blood-of-rats-exposed-to-chronic-intermittent-hypoxia-therapeutic-strategies
#15
Marisol Domínguez-Álvarez, Joaquim Gea, Esther Barreiro
We hypothesized that inflammatory events and reactive oxygen species (ROS) production may be differentially expressed in respiratory and limb muscles, and blood of a chronic intermittent hypoxia (CIH) experimental model and that antioxidants and TNF-alpha blockade may influence those events. In blood, diaphragm, and gastrocnemius of rats non-invasively exposed to CIH (10% hypoxia, two hours/day, 14 consecutive days) with/without concomitant treatment with either anti-TNF-alpha antibody (infliximab) or N-acetyl cysteine (NAC), inflammatory cytokines, superoxide anion production, muscle structural abnormalities, and fiber-type composition were assessed...
September 16, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27615665/inspiratory-modulation-of-sympathetic-activity-is-increased-in-female-rats-exposed-to-chronic-intermittent-hypoxia
#16
George Miguel P R Souza, Leni G H Bonagamba, Mateus R Amorim, Davi J A Moraes, Benedito H Machado
What is the central question of the study? There are sex differences in the respiratory network and in the regulation of arterial blood pressure. Female rats develop hypertension after chronic intermittent hypoxia (CIH). In this context, we evaluated the respiratory-related mechanism underlying the development of hypertension in CIH-exposed female rats. What is the main finding and its importance? Female rats exposed to CIH develop changes in the respiratory pattern related to inspiration and sympathetic overactivity phase locked to the inspiratory phase of the respiratory cycle, which is different from CIH-exposed male rats...
September 12, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27609199/heme-oxygenase-1-dependent-central-cardiorespiratory-adaptations-to-chronic-intermittent-hypoxia-in-mice
#17
Jag Sunderram, John Semmlow, Pranav Patel, Harshit Rao, Glen Chun, Priya Agarwala, Mantu Bhaumik, Oanh Le-Hoang, Shou-En Lu, Judith A Neubauer
Chronic intermittent hypoxia (CIH) increases sympathetic tone, and respiratory instability. Our previous work showed that chronic hypoxia induces the oxygen sensing enzyme, heme oxygenase-1 (HO-1) within the C1 sympathoexcitatory region and the pre-Bötzinger complex (pre-BötC). We therefore examined the effect of CIH on time course of induced expression of HO-1 within these regions and determined whether the induction of HO-1 correlated with changes in respiratory, sigh frequency, and sympathetic responses (spectral analysis of heart rate) to acute hypoxia (10%O2) during 10 days of exposure to CIH in chronically instrumented awake wild type (WT) and HO-1 null mice (HO-1(-/-))...
September 8, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27600005/-effect-of-chronic-intermittent-hypoxia-on-the-expression-of-cxc-chemokine-ligand-10-in-rat-liver-and-the-interventional-effect-of-n-acetylcysteine
#18
Bin Liu, Xiaoli Su, Yan Zhang, Li Huang, Pinhua Pan, Chengping Hu
OBJECTIVE: To explore the effect of chronic intermittent hypoxia (CIH) on liver injury and to examine the expression of liver CXC chemokine ligand-10 (CXCL10) in the rats, and to explore the effect of N-acetylcysteine (NAC).
 METHODS: A total of 21 male SD rats were randomly divided into a control group, a CIH group and a CIH+NAC group (n=7 in each group). The control group exposed to normal gaseous environment, the other 2 groups were exposed to CIH for 5 weeks (8 h/d); the control group and the CIH group were given daily saline lavage, the CIH+NAC group daily received NAC solution...
August 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/27599201/angiotensin-1-7-inhibits-inflammation-and-oxidative-stress-to-relieve-lung-injury-induced-by-chronic-intermittent-hypoxia-in-rats
#19
W Lu, J Kang, K Hu, S Tang, X Zhou, S Yu, Y Li, L Xu
Obstructive sleep apnea is associated with inflammation and oxidative stress in lung tissues and can lead to metabolic abnormalities. We investigated the effects of angiotensin1-7 [Ang-(1-7)] on lung injury in rats induced by chronic intermittent hypoxia (CIH). We randomly assigned 32 male Sprague-Dawley rats (180-200 g) to normoxia control (NC), CIH-untreated (uCIH), Ang-(1-7)-treated normoxia control (N-A), and Ang-(1-7)-treated CIH (CIH-A) groups. Oxidative stress biomarkers were measured in lung tissues, and expression of NADPH oxidase 4 (Nox4) and Nox subunits (p22phox, and p47phox) was determined by Western blot and reverse transcription-polymerase chain reaction...
September 1, 2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/27595979/oxidative-stress-augments-chemoreflex-sensitivity-in-rats-exposed-to-chronic-intermittent-hypoxia
#20
Barbara J Morgan, Melissa L Bates, Rodrigo Del Rio, Zunyi Wang, John M Dopp
Chronic exposure to intermittent hypoxia (CIH) elicits plasticity of the carotid sinus and phrenic nerves via reactive oxygen species (ROS). To determine whether CIH-induced alterations in ventilation, metabolism, and heart rate are also dependent on ROS, we measured responses to acute hypoxia in conscious rats after 14 and 21 d of either CIH or normoxia (NORM), with or without concomitant administration of allopurinol (xanthine oxidase inhibitor), combined allopurinol plus losartan (angiotensin II type 1 receptor antagonist), or apocynin (NADPH oxidase inhibitor)...
December 2016: Respiratory Physiology & Neurobiology
keyword
keyword
9379
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"