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https://www.readbyqxmd.com/read/29775122/nitration-of-mnsod-in-the-carotid-body-and-adrenal-gland-induced-by-chronic-intermittent-hypoxia
#1
Esteban A Moya, Paulina Arias, Rodrigo Iturriaga
Chronic intermittent hypoxia (CIH), main feature of obstructive sleep apnea, produces nitro-oxidative stress, which contributes to potentiate carotid body (CB) chemosensory discharges and sympathetic-adrenal-axis activity, leading to hypertension. The MnSOD enzymatic activity, a key enzyme on oxidative stress control, is reduced by superoxide-induced nitration. However, the effects of CIH-induced nitration on MnSOD enzymatic activity in the CB and adrenal gland are not known. We studied the effects of CIH on MnSOD protein and immunoreactive (MnSOD-ir) levels in the CB, adrenal gland and superior cervical ganglion (SCG), and on 3-nitrotyrosine (3-NT-ir), CuZnSOD (CuZnSOD-ir), MnSOD nitration, and its enzymatic activity in the CB and adrenal gland from male Sprague-Dawley rats exposed to CIH for 7 days...
May 1, 2018: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/29770919/dl-propargylglycine-protects-against-myocardial-injury-induced-by-chronic-intermittent-hypoxia-through-inhibition-of-endoplasmic-reticulum-stress
#2
Xiufang Zhou, Si Tang, Ke Hu, Zhan Zhang, Pei Liu, Yuchuan Luo, Jing Kang, Lifang Xu
BACKGROUND: Chronic intermittent hypoxia (CIH), an important basis of the pathogenesis of organ damage induced by obstructive sleep apnea syndrome (OSAS), is associated with myocardial injury, such as left ventricular dysfunction, apoptosis, and oxidative stress. Endogenous hydrogen sulfide (H2 S) plays an important role in maintaining cardiovascular functions. Many studies have demonstrated that exogenous H2 S has protective effects against myocardial injury induced by various cardiovascular diseases, and inhibiting the generation of endogenous H2 S has opposite effects...
May 16, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29758366/curcumin-attenuates-chronic-intermittent-hypoxia-induced-brain-injuries-by-inhibiting-aqp4-and-p38-mapk-pathway
#3
Bo Wang, Wenyang Li, Hongyu Jin, Xinshi Nie, Hui Shen, Erran Li, Wei Wang
Chronic intermittent hypoxia (CIH) is one of the main features of obstructive sleep apnea (OSA), which is also commonly associated with neurocognitive impairments. The present study aimed to elucidate the beneficial effect of curcumin on CIH-induced brain injuries. Male balb/c mice (6 ∼ 8 weeks) were exposed to normoxia or a pattern of CIH (8 h/day, cycles of 180 sec each, hypoxia: 5% O2 for 50 sec, reoxygenation: 21% O2 for 50 sec) for 10 weeks, along with daily curcumin treatment (50, 100, or 200 mg/kg, intragastrically) or its vehicle...
May 11, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29755703/gut-colonization-with-carbapenem-resistant-enterobacteriaceae-adversely-impacts-the-outcome-in-patients-with-hematological-malignancies-results-of-a-prospective-surveillance-study
#4
Sarita Rani Jaiswal, Satyanker Gupta, Rekha Saji Kumar, Amit Sherawat, Ashok Rajoreya, Saroj K Dash, Gitali Bhagwati, Suparno Chakrabarti
Background: Gut colonisation with carbapenem-resistant enterobacteriaceae (CRE) is a risk factor for CRE bacteremia and patients with haematological malignancies (HM) are at the highest risk of mortality. Methods: We conducted a prospective surveillance study of gut colonisation with CRE and its impact on the outcome of 225 consecutive patients of HM over 28 months. Results: The median age of the cohort was 46 years, the majority with acute leukaemia...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29750475/effects-of-losartan-and-allopurinol-on-cardiorespiratory-regulation-in-obstructive-sleep-apnoea
#5
Barbara J Morgan, Mihaela Teodorescu, David F Pegelow, Emily R Jackson, Devin L Schneider, David T Plante, James P Gapinski, Scott J Hetzel, John M Dopp
Chemoreflex sensitization produced by chronic intermittent hypoxia (CIH) in rats is attenuated by angiotensin II type 1 receptor (AT1 R) blockade. AT1 R blockade and xanthine oxidase inhibition both ameliorate CIH-induced endothelial dysfunction. We hypothesized treatment with losartan and allopurinol would reduce chemoreflex sensitivity and improve hypoxic vasodilation in patients with obstructive sleep apnoea (OSA). Eighty-six hypertensive patients with apnoea-hypopnoea index ≥25 events/hr and no other cardiovascular, pulmonary, renal, or metabolic disease were randomly assigned to receive allopurinol, losartan, or placebo for 6 weeks...
May 11, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29748437/quantitative-competitive-allele-specific-taqman-duplex-pcr-qcast-duplex-pcr-assay-a-refined-method-for-highly-sensitive-and-specific-detection-of-jak2v617f-mutant-allele-burdens
#6
Chia-Chen Hsu, Cih-En Huang, Yu-Ying Wu, Yi-Yang Chen, Jrhau Lung, Yu-Wei Leu, Chian-Pei Li, Hsing-Yi Tsou, Wei-Hsuan Chuang, Chang-Hsien Lu, Chih-Cheng Chen
No abstract text is available yet for this article.
May 10, 2018: Haematologica
https://www.readbyqxmd.com/read/29737211/hepatoprotective-effect-of-wedelolactone-against-concanavalin-a-induced-liver-injury-in-mice
#7
Qingqiong Luo, Jieying Ding, Liping Zhu, Fuxiang Chen, Lili Xu
Eclipta prostrata L. is a traditional Chinese herbal medicine that has been used in the treatment of liver diseases. However, its biological mechanisms remain elusive. The current study aimed to investigate the hepatoprotective effect of wedelolactone, a major coumarin ingredient of Eclipta prostrata L., on immune-mediated liver injury. Using the well-established animal model of Concanavalin A (ConA)-induced hepatitis (CIH), we found that pretreatment of mice with wedelolactone markedly reduced both the serum levels of transaminases and the severity of liver damage...
May 8, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29723577/ampa-receptor-dependent-glutamatergic-signaling-is-present-in-the-carotid-chemoreceptor
#8
Yuzhen Liu, Chaohong Li, Xianglei Jia, Lu Huang, J Woodrow Weiss
Exposure to both sustained and intermittent hypoxia for as little as a day produces sustained augmentation of carotid chemoreceptor sensitivity; however, the molecular basis for this chemoreflex plasticity remains uncertain. We previously reported that NMDA receptor dependent glutamatergic signaling in rat carotid body played a role in altered hypoxic sensitivity after exposure to cyclic intermittent hypoxia (CIH). Here we found that mRNAs of multiple AMPA and Kainate glutamate receptors were expressed in rat carotid body...
April 30, 2018: Neuroscience
https://www.readbyqxmd.com/read/29702204/chronic-intermittent-hypoxia-induces-changes-on-the-expression-and-activity-of-neprilysin-ec-3-4-24-16-in-the-brain-of-rats
#9
Renato W de Oliveira, Guilherme S Julian, Juliana C Perry, Sergio Tufik, Jair R Chagas
Obstructive sleep apnea (OSA) is a frequent sleeping breathing disorder associated with cognitive impairments. Neprilysin (NEP) is responsible for degrading several substrates related to cognition; however, the effect of chronic intermittent hypoxia (CIH) on NEP is still unknown. This study aimed to evaluate the expression and activity of NEP under CIH in cognitive-related brain structures. Western blot, qRT-PCR and enzyme activity assay, demonstrated that a six-week intermittent hypoxia increased NEP expression and activity, selectively in temporal cortex, but not in the hippocampus and frontal cortex...
April 24, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29697839/brain-derived-erythropoietin-protects-from-intermittent-hypoxia-induced-cardiorespiratory-dysfunction-and-oxidative-stress-in-mice
#10
Elizabeth Elliot-Portal, Sofien Laouafa, Christian Arias-Reyes, Tara Adele Janes, Vincent Joseph, Jorge Soliz
Study Objectives: Based on the fact that erythropoietin (Epo) administration in rodents protects against spatial learning and cognitive deficits induced by chronic intermittent hypoxia (CIH)-mediated oxidative damage, here we tested the hypothesis that Epo in the brain protects against cardiorespiratory disorders and oxidative stress induced by CIH in adult mice. Methods: Adult control and transgenic mice overexpressing Epo in the brain only (Tg21) were exposed to CIH (21%-10% O2-10 cycles/hour-8 hours/day-7 days) or room air...
April 25, 2018: Sleep
https://www.readbyqxmd.com/read/29676627/effect-of-world-trade-center-dust-exposure-and-chronic-intermittent-hypoxia-on-macrophage-matrix-metalloproteinase-12-expression-in-mice
#11
Jared Radbel, Oanh Le-Hoang, Kinal N Vayas, Kaiwal Patel, Michael Goedken, Vasanthi R Sunil, Debra Laskin, Jag Sunderram
RATIONALE: The pathophysiologic mechanisms by which World Trade Center (WTC) dust exposure leads to pulmonary disease have not been established. Matrix metalloproteinase-12 (MMP-12) is involved in the development of pulmonary fibrosis and chronic obstructive pulmonary disease. We have previously shown that exposure of mice to WTC dust results in increased expression of matrix metalloproteinase 12 by alveolar macrophages. Matrix metalloproteinase 12 expression is regulated, in part, by oxidative stress, which is also increased after WTC dust exposure...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29662720/role-of-active-versus-passive-complementary-and-integrative-health-approaches-in-pain-management
#12
David Cosio, Erica Lin
Background: A general conclusion about the treatment of chronic, noncancer pain is that the results from traditional, passive modalities are disheartening. Perhaps this may be due to the propensity of patients to seek out passive versus active treatments. In pain management, active treatments should be the primary focus, with passive interventions as an adjunct. Objective: The current study tested the hypotheses that Veterans would report a greater significant increase in active versus transitional and active versus passive complementary and integrative health (CIH) utilization after completing a formal pain education program...
2018: Global Advances in Health and Medicine: Improving Healthcare Outcomes Worldwide
https://www.readbyqxmd.com/read/29620393/veteran-participation-in-the-integrative-health-and-wellness-program-impact-on-self-reported-mental-and-physical-health-outcomes
#13
Amanda Hull, Stephanie Brooks Holliday, Christine Eickhoff, Patrick Sullivan, Rena Courtney, Kayla Sossin, Alyssa Adams, Matthew Reinhard
Complementary and integrative health (CIH) services are being used more widely across the nation, including in both military and veteran hospital settings. Literature suggests that a variety of CIH services show promise in treating a wide range of physical and mental health disorders. Notably, the Department of Veterans Affairs is implementing CIH services within the context of a health care transformation, changing from disease based health care to a personalized, proactive, patient-centered approach where the veteran, not the disease, is at the center of care...
April 5, 2018: Psychological Services
https://www.readbyqxmd.com/read/29607154/decreased-expression-of-hepatic-cytochrome-p450-1a2-cyp1a2-in-a-chronic-intermittent-hypoxia-mouse-model
#14
Xiao-Bin Zhang, Yi-Ming Zeng, Xiao-Yang Chen, Yi-Xiang Zhang, Jin-Zhen Ding, Cheng Xue
Background: Hepatic cytochrome P450 (CYP) isoforms, CYP1A2, is one of important enzymes for many drugs metabolism. Studies have confirmed that sustained hypoxia can influence the expression of hepatic CYP, including CYP1A2. The impact of chronic intermittent hypoxia (CIH), a marked characteristic of sleep apnea, on CYP1A2 remains unclear. The aim of the present study was to evaluate the effect of CIH on the expression of hepatic CYP1A2 in a mouse model with sleep apnea. Methods: Twenty four old male (6-8 weeks) C57BL/6J mice (n=12 in each group) were randomly assigned to either normoxia group or CIH group...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29584926/evaluation-of-complementary-and-integrative-health-approaches-among-us-veterans-with-musculoskeletal-pain-using-propensity-score-methods
#15
Ling Han, Joseph L Goulet, Melissa Skanderson, Harini Bathulapalli, Stephen L Luther, Robert D Kerns, Cynthia A Brandt
Objectives: To examine the treatment effectiveness of complementary and integrative health approaches (CIH) on chronic pain using Propensity Score (PS) methods. Design, Settings, and Participants: A retrospective cohort of 309,277 veterans with chronic musculoskeletal pain assessed over three years after initial diagnosis. Methods: CIH exposure was defined as one or more clinical visits for massage, acupuncture, or chiropractic care. The treatment effect of CIH on self-rated pain intensity was examined using a longitudinal model...
March 23, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29574103/sevoflurane-exaggerates-cognitive-decline-in-a-rat-model-of-chronic-intermittent-hypoxia-by-aggravating-microglia-mediated-neuroinflammation-via-downregulation-of-ppar-%C3%AE-in-the-hippocampus
#16
Ping Dong, Jian Zhao, Ning Li, Lu Lingling, Liang Li, Xiyan Zhang, Yang Bo, Zhang Li, Dongliang Li
Postoperative cognitive dysfunction is a common complication associated with anesthesia and surgery. Sevoflurane is a widely used volatile anesthetic in the clinical setting. Preclinical studies show that sevoflurane alone does not appear to cause cognitive dysfunction. Here, we examined whether sevoflurane induces cognitive decline under chronic intermittent hypoxia (CIH) conditions. Rats were exposed to CIH or control for 4 weeks. Two weeks after starting intermittent hypoxia, these animals underwent either 2...
March 21, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29561178/effect-of-chronic-intermittent-hypoxia-on-angiotensin-ii-receptors-in-the-central-nervous-system
#17
Barbara J Morgan, Nicole Schrimpf, Morgan Rothman, Ann Mitzey, Mark S Brownfield, Robert C Speth, John M Dopp
Chronic intermittent hypoxia (CIH) increases basal sympathetic nervous system activity, augments chemoreflex-induced sympathoexcitation, and raises blood pressure. All effects are attenuated by systemic or intracerebroventricular administration of angiotensin II type 1 receptor (AT1 R) antagonists. This study aimed to quantify the effects of CIH on AT1 R- and AT2 R-like immunoreactivity in the rostroventrolateral medulla (RVLM) and paraventricular nucleus of the hypothalamus (PVN), central regions that are important components of the extended chemoreflex pathway...
March 21, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29550481/protective-effect-of-sphingosine-1-phosphate-for-chronic-intermittent-hypoxia-induced-endothelial-cell-injury
#18
Fu-Chao Yu, Chu-Xiao Yuan, Jia-Yi Tong, Guang-Hao Zhang, Fang-Ping Zhou, Fang Yang
Intermittent hypoxia (IH) induced by obstructive sleep apnea (OSA) is the key factor in oxidative stress and the concomitant inflammation of endothelial cells (ECs). In recent years, the lipid sphingosine-1-phosphate (S1P) has been reported to probably play a central role in inflammatory diseases. However, its role in IH-induced endothelial injury remains uncertain. In this study, we investigated the IH-induced ECs inflammation and apoptosis, as well as the role of S1P in both. First, human umbilical vein endothelial cells (HUVECs) were treated with IH to explore the mechanism of S1P and S1P microbubbles (S1P-MBs) in HUVECs with altered function...
April 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29549235/sinomenine-attenuates-chronic-intermittent-hypoxia-induced-lung-injury-by-inhibiting-inflammation-and-oxidative-stress
#19
Xiaofeng Zhang, Lijun Rui, Mei Wang, Hairong Lian, Liming Cai
BACKGROUND In the present study, we aimed to investigate the effects of sinomenine (SIN) on chronic intermittent hypoxia (CIH)- induced lung injury in rats, and to explore the underlying mechanisms. MATERIAL AND METHODS To perform the investigation, a CIH rat model was established. ELISA assay was applied to detect the level of inflammatory cytokines. Oxidative stress bio-markers (MDA, SOD, and CAT) were determined in lung tissues. In addition, the expression level of NADPH oxidase 2 (Nox2) was analyzed by Western blotting and qRT-PCR, respectively...
March 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29535617/yoga-therapy-and-polyvagal-theory-the-convergence-of-traditional-wisdom-and-contemporary-neuroscience-for-self-regulation-and-resilience
#20
Marlysa B Sullivan, Matt Erb, Laura Schmalzl, Steffany Moonaz, Jessica Noggle Taylor, Stephen W Porges
Yoga therapy is a newly emerging, self-regulating complementary and integrative healthcare (CIH) practice. It is growing in its professionalization, recognition and utilization with a demonstrated commitment to setting practice standards, educational and accreditation standards, and promoting research to support its efficacy for various populations and conditions. However, heterogeneity of practice, poor reporting standards, and lack of a broadly accepted understanding of the neurophysiological mechanisms involved in yoga therapy limits the structuring of testable hypotheses and clinical applications...
2018: Frontiers in Human Neuroscience
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