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https://www.readbyqxmd.com/read/29329429/how-to-convene-an-international-health-or-development-commission-ten-key-steps
#1
Gavin Yamey, Lawrence H Summers, Dean T Jamison, Jessica Brinton
The Commission on Investing in Health (CIH), an international group of 25 economists and global health experts, published its Global Health 2035 report in The Lancet in December 2013. The report laid out an ambitious investment framework for achieving a "grand convergence" in health-a universal reduction in deaths from infectious diseases and maternal and child health conditions-within a generation. This article captures ten key elements that the CIH found important to its process and successful outcomes. The elements are presented in chronological order, from inception to post-publication activities...
January 10, 2018: Health Policy and Planning
https://www.readbyqxmd.com/read/29316671/shell-layer-thickness-dependent-photocatalytic-activity-of-sputtering-synthesized-hexagonally-structured-zno-zns-composite-nanorods
#2
Yuan-Chang Liang, Ya-Ru Lo, Chein-Chung Wang, Nian-Cih Xu
ZnO-ZnS core-shell nanorods are synthesized by combining the hydrothermal method and vacuum sputtering. The core-shell nanorods with variable ZnS shell thickness (7-46 nm) are synthesized by varying ZnS sputtering duration. Structural analyses demonstrated that the as-grown ZnS shell layers are well crystallized with preferring growth direction of ZnS (002). The sputtering-assisted synthesized ZnO-ZnS core-shell nanorods are in a wurtzite structure. Moreover, photoluminance spectral analysis indicated that the introduction of a ZnS shell layer improved the photoexcited electron and hole separation efficiency of the ZnO nanorods...
January 7, 2018: Materials
https://www.readbyqxmd.com/read/29299785/investigation-into-complementary-and-integrative-health-approaches-for-turkish-patients-with-gastrointestinal-cancer
#3
Seda Pehlivan, Ali Süner, Yasemin Yıldırım, Çiçek Fadıloğlu
The study was conducted to determine the levels of usage of complementary and integrative health (CIH) approaches and the symptoms experienced by Turkish patients with gastrointestinal cancer. A descriptive study was conducted on 81 patients with gastrointestinal cancer attending the medical oncology department of an oncology hospital. In the data collection stage, the patient description form that prepared by the researchers and the "Edmonton Symptom Assessment Scale" were used. Data were evaluated via Chi-square and student t test...
January 3, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/29246449/contribution-of-relative-leptin-and-adiponectin-deficiencies-in-premature-infants-to-chronic-intermittent-hypoxia-exploring-a-new-hypothesis
#4
REVIEW
Estelle B Gauda, Zankhana Master
Chronic intermittent hypoxia (CIH) occurs frequently in premature infants who have apnea of prematurity. Immaturity of the respiratory network from low central respiratory drive and the greater contribution of the carotid body on baseline breathing leads to respiratory instability in premature infants presenting as apnea and periodic breathing. During the 2nd week after birth, the smallest and the youngest premature infants have increased frequency of apnea and periodic breathing and associated oxygen desaturations that can persist for weeks after birth...
December 12, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29203815/role-of-ventral-medullary-catecholaminergic-neurons-for-respiratory-modulation-of-sympathetic-outflow-in-rats
#5
Davi J A Moraes, Leni G H Bonagamba, Melina P da Silva, Julian F R Paton, Benedito H Machado
Sympathetic activity displays rhythmic oscillations generated by brainstem inspiratory and expiratory neurons. Amplification of these rhythmic respiratory-related oscillations is observed in rats under enhanced central respiratory drive or during development of neurogenic hypertension. Herein, we evaluated the involvement of ventral medullary sympatho-excitatory catecholaminergic C1 neurons, using inhibitory Drosophila allatostatin receptors, for the enhanced expiratory-related oscillations in sympathetic activity in rats submitted to chronic intermittent hypoxia (CIH) and following activation of both peripheral (hypoxia) and central chemoreceptors (hypercapnia)...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29194973/perovskite-quantum-dots-and-their-application-in-light-emitting-diodes
#6
REVIEW
Hung-Chia Wang, Zhen Bao, Hsin-Yu Tsai, An-Cih Tang, Ru-Shi Liu
Perovskite quantum dots (PQDs) attract significant interest in recent years because of their unique optical properties, such as tunable wavelength, narrow emission, and high photoluminescence quantum efficiency (PLQY). Recent studies report new types of formamidinium (FA) PbBr3 PQDs, PQDs with organic-inorganic mixed cations, divalent cation doped colloidal CsPb1-x Mx Br3 PQDs (M = Sn2+ , Cd2+ , Zn2+ , Mn2+ ) featuring partial cation exchange, and heterovalent cation doped into PQDs (Bi3+ ). These PQD analogs open new possibilities for optoelectronic devices...
November 30, 2017: Small
https://www.readbyqxmd.com/read/29163342/novel-anterior-brainstem-magnetic-resonance-imaging-findings-in-non-small-cell-lung-cancer-with-leptomeningeal-carcinomatosis
#7
Chun-Yu Cheng, Chia-Yu Hsu, Yuan-Hsiung Tsai, Kuang-Lin Lin, Cih-En Huang, Yi-Hong Fan, Shy-Chyi Chin, Yen-Chu Huang
Leptomeningeal carcinomatosis (LC) is found in around 4% of patients with non-small cell lung cancer (NSCLC). The most common radiological finding of LC is diffuse leptomeningeal enhancement on contrast-enhanced brain magnetic resonance imaging (MRI). Herein, we report a novel brain MRI finding-non-enhanced, band-like, symmetric restricted diffusion along the anterior surface of the brainstem-of LC in four patients with NSCLC. We also identified three additional cases with similar MRI findings in a literature review...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29159869/acute-intermittent-hypoxia-with-concurrent-hypercapnia-evokes-p2x-and-trpv1-receptor-dependent-sensory-long-term-facilitation-in-na%C3%A3-ve-carotid-bodies
#8
Arijit Roy, Melissa M J Farnham, Fatemeh Derakhshan, Paul M Pilowsky, Richard J A Wilson
Apneas constitute an acute existential threat to neonates and adults. In large part, this threat is detected by the carotid bodies, the primary peripheral chemoreceptors, and combatted by arousal and acute cardiorespiratory responses, including increased sympathetic output. Similar responses occur with repeated apneas but they continue beyond the last apnea and can persist for hours (i.e. ventilatory and sympathetic LTF). These long-term effects may be adaptive during acute episodic apnea, but may prolong hypertension causing chronic cardiovascular impairment...
November 21, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29157231/risk-factors-for-contralateral-inguinal-hernia-repair-after-unilateral-inguinal-hernia-repair-in-male-adult-patients-analysis-from-a-nationwide-population-based-cohort-study
#9
Cheng-Hung Lee, Yu-Ting Chiu, Chi-Fu Cheng, Jin-Chia Wu, Wen-Yao Yin, Jian-Han Chen
BACKGROUND: To identify the rate of and risk factors for contralateral inguinal hernia (CIH) after unilateral inguinal hernia repair in adult male patients. METHODS: This retrospective cohort study identified from the Taiwan National Health Insurance Research Database (NHIRD). Information on all adult patients who underwent primary unilateral inguinal hernia repair without any other operation was collected using ICD-9 diagnostic and procedure codes. The exclusion criteria were laparoscopic hernia repair, non-primary repair, complicated hernia, other combined procedures, female and undetermined gender...
November 21, 2017: BMC Surgery
https://www.readbyqxmd.com/read/29127294/preventing-shivering-with-adjuvant-low-dose-intrathecal-meperidine-a-meta-analysis-of-randomized-controlled-trials-with-trial-sequential-analysis
#10
Yu-Cih Lin, Chien-Yu Chen, Yuan-Mei Liao, Alan Hsi-Wen Liao, Pi-Chu Lin, Chuen-Chau Chang
The aim of this systematic review and meta-analysis is to evaluate the pros and cons of adjuvant low dose intrathecal meperidine for spinal anaesthesia. We searched electronic databases for randomized controlled trials using trial sequential analysis (TSA) to evaluate the incidence of reduced rescue analgesics, shivering, pruritus, nausea and vomiting when applying adjuvant intrathecal meperidine. Twenty-eight trials with 2216 patients were included. Adjuvant intrathecal meperidine, 0.05-0.5 mg kg-1, significantly reduced incidence of shivering (relative risk, RR, 0...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29125239/hippocampal-sparing-approach-in-fractionated-stereotactic-brain-vmat-radio-therapy-a-retrospective-feasibility-analysis
#11
Maria Daniela Falco, Stefano Giancaterino, Marco D'Andrea, Ramon Gimenez De Lorenzo, Marianna Trignani, Luciana Caravatta, Clelia Di Carlo, Saide Di Biase, Albina Allajbej, Domenico Genovesi
Volumetric Modulated Arc Therapy (VMAT) techniques for fractioned stereotactic brain radiotherapy (FSBRT) can achieve highly conformal dose distribution to intracranial lesions. However, they can potentially increase the dose to hippocampus (H) causing neurocognitive toxicity during the first four months after irradiation. The purpose of this study was to assess the feasibility of hippocampal-sparing (HS) treatment plans in 22 patients with brain metastasis treated with VMAT technique. Firstly, we retrospectively analyzed hippocampal doses in all 22 VMAT original (not hippocampal-sparing, NHS) plans...
November 10, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29124628/chronic-intermittent-hypoxia-exposure-induces-kidney-injury-in-growing-rats
#12
Neha-Devi Poonit, Yi-Chun Zhang, Chu-Yuan Ye, Hui-Lin Cai, Chen-Yi Yu, Ting Li, Xiao-Hong Cai
OBJECTIVE: The objectives of this paper are to examine the effect of chronic intermittent hypoxia (CIH) on the morphological changes in the kidney of growing rats and to explore the mechanisms underlying the CIH-induced renal damage. METHODS: Forty Sprague-Dawley rats were randomly divided into two groups: 2 and 4 weeks CIH groups (2IH, 4IH), and in the control group 2 and 4 weeks air-stimulated groups (2C, 4C), with 10 rats in each group. Pathological changes of renal tissue were observed by HE staining, PAS staining, and Masson staining...
November 9, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29108914/detection-and-analysis-of-apoptosis-and-autophagy-related-mirnas-of-mouse-vascular-endothelial-cells-in-chronic-intermittent-hypoxia-model
#13
Kai-Xiong Liu, Gong-Ping Chen, Ping-Li Lin, Jian-Chai Huang, Xin Lin, Jia-Chao Qi, Qi-Chang Lin
Endothelial dysfunction is the main pathogenic mechanism of cardiovascular complications induced by obstructive sleep apnea/hyponea syndrome (OSAHS). Chronic intermittent hypoxia (CIH) is the primary factor of OSAHS-associated endothelial dysfunction. The hypoxia inducible factor (HIF) pathway regulates the expression of downstream target genes and mediates cell apoptosis caused by CIH-induced endothelial injury. miRNAs play extensive and important negative regulatory roles in this process at the post-transcriptional level...
January 15, 2018: Life Sciences
https://www.readbyqxmd.com/read/29108369/nephroureterectomy-increase-5-year-survival-in-patients-on-dialysis-with-upper-urinary-tract-urothelial-carcinoma
#14
Cih-En Huang, Yao-Hsu Yang, Wen-Cheng Chen, Kuo-Tsai Huang, Pau-Chung Chen, Ying-Huang Tsai, Wei-Yu Lin
Background: There is a high incidence rate of upper tract urothelial carcinoma (UTUC) in patients on dialysis. However, the studies about nephroureterectomy (NU) in this high surgical risk group are limited. The aim of this study is to investigate the outcomes of NU in this population. Results: There were total 931 patients enrolled and 218, 582, 131 patients were non-NU, unilateral and one-stage bilateral NU, respectively. NU provided better 5-year overall survival (66% versus 51% in non-NU, P = 0...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29083263/fifteen-years-experience-with-laparoscopic-inguinal-hernia-repair-in-infants-and-children
#15
Rafik Shalaby, Mohamed Abd Alrazek, Adham Elsaied, Ahmad Helal, Mohamad Mahfouz, Maged Ismail, Abdelmoniem Shams, Mohamad Magid
BACKGROUND: Laparoscopic inguinal hernia repair (LIHR) is gaining popularity with more studies validating its feasibility, safety, and efficacy. The aim of this work is to review our experience with LIHR in infants and children during the past 15 years, and present and evaluate our innovations of laparoscopic techniques. PATIENTS AND METHODS: A retrospective study of 1284 patients with congenital inguinal hernia (CIH) subjected to different techniques of LIHR from October 2000 to October 2015...
January 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29038619/alteration-of-inflammatory-mediators-in-the-upper-and-lower-airways-under-chronic-intermittent-hypoxia-preliminary-animal-study
#16
Eun Jung Lee, Woon Heo, Joo Young Kim, Hyungchul Kim, Min Jung Kang, Bo Ra Kim, Ji Hyun Kim, Do Yang Park, Chang-Hoon Kim, Joo-Heon Yoon, Hyung-Ju Cho
PURPOSE: We hypothesized that CIH may affect the upper airway immune system and aimed to verify whether CIH can induce airway inflammation in a murine obstructive sleep apnea (OSA) model. METHODS: C57BL6 male mice were exposed to intermittent hypoxia (CIH group; 5 ~ 21% FiO2, 120 sec cycles, 12 h/d, n = 6) or room air (Sham group, n = 6) for up to 4 weeks in identical chambers. Nasal and lung tissues and lavage fluid were collected and analyzed by multiplex assay...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28985491/tanshinone-iia-ameliorated-endothelial-dysfunction-in-rats-with-chronic-intermittent-hypoxia
#17
Lingling Chen, Qiu-Hong Guo, Yue Chang, Ya-Shuo Zhao, Ai-Ying Li, En-Sheng Ji
Chronic intermittent hypoxia (CIH) during repetitive airflow cessations may cause endothelial dysfunction. Tanshinone IIA (Tan IIA) has been used to treat various circulatory disturbance-related diseases because of its pharmacological actions, including vasodilation. However, the mechanism of the effect of its vasodilation is not well established. The objective of this study was to explore the effect of Tan IIA in endothelium-dependent contracting factors and endothelin receptors in aortic endothelial dysfunction in CIH rats...
June 30, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28983603/inflammatory-and-oxidative-stress%C3%A2-associated-factors-in-chronic-intermittent-hypoxia-in-chinese-patients-rats-lymphocytes-and-endotheliocytes
#18
Hui Ren, Ke Hu
In order to investigate the association between inflammatory and oxidative stress (OS)‑associated factors in chronic intermittent hypoxia (CIH), 238 CIH patients and 156 healthy volunteers were included. CIH rat and lymphocytes were used as experimental models. Interleukin (IL)‑6, tumor necrosis factor‑α (TNF‑α), C‑reactive protein (CRP), nitric oxide (NO) and nitric oxide synthase (NOS) were analyzed. Patients with CIH were older, with hypertension, increased heart rate (HR) and body mass index (BMI), and there were more males than females...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28977625/hiv-stigma-and-older-men-s-psychological-well-being-do-coping-resources-differ-for-gay-bisexual-and-straight-men
#19
Kristen E Porter, Mark Brennan-Ing, Jeffrey A Burr, Elizabeth Dugan, Stephen E Karpiak
Objectives: This study investigated whether sexual orientation moderated the mediation effects of coping resources (i.e., spirituality and complementary and integrative health [CIH] use) in the relationship between HIV stigma and psychological well-being (PWB) among older men with HIV (MWH). Method: Data from the Research of Older Adults with HIV (ROAH) study was used (N = 640, Age 50+). Structural equation modeling (SEM) was employed to examine a coping resource mediation model...
July 21, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28969658/characterization-and-epitope-mapping-of-dengue-virus-type-1-specific-monoclonal-antibodies
#20
Wen-Hung Chen, Feng-Pai Chou, Yu-Kuo Wang, Sheng-Cih Huang, Chuan-Hung Cheng, Tung-Kung Wu
BACKGROUND: Dengue virus (DV) infection causes a spectrum of clinical diseases ranging from dengue fever to a life-threatening dengue hemorrhagic fever. Four distinct serotypes (DV1-4), which have similar genome sequences and envelope protein (E protein) antigenic properties, were divided. Among these 4 serotypes, DV1 usually causes predominant infections and fast diagnosis and effective treatments are urgently required to prevent further hospitalization and casualties. METHODS: To develop antibodies specifically targeting and neutralizing DV1, we immunized mice with UV-inactivated DV1 viral particles and recombinant DV1 E protein from residue 1 to 395 (E395), and then generated 12 anti-E monoclonal antibodies (mAbs) as the candidates for a series of characterized assays such as ELISA, dot blot, immunofluorescence assay, western blot, and foci forming analyses...
October 2, 2017: Virology Journal
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