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MicroRNA and pain

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https://www.readbyqxmd.com/read/28225487/comparing-serum-microrna-levels-of-acute-herpes-zoster-patients-with-those-of-postherpetic-neuralgia-patients
#1
Ying Huang, Xihan Li, Gaojian Tao, Tong Zhu, Jian Lin
Postherpetic neuralgia (PHN) is commonly defined as pain persisting for at least 3 months after acute herpes zoster (AHZ) rash presentation. About one-tenth of all acute herpes zoster patients develop PHN. Circulating microRNAs (miRNAs) are promising biomarkers for infectious diseases; however, there has been no relationship established between circulating miRNAs and PHN to date; the aim of the present investigation was to elucidate this relationship.We compared serum levels of miRNA in PHN and AHZ patients...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28214854/microrna-183-suppresses-neuropathic-pain-and-expression-of-ampa-receptors-by-targeting-mtor-vegf-signaling-pathway
#2
Xiaojuan Xie, Ligang Ma, Kai Xi, Wei Zhang, Dongmei Fan
BACKGROUND: Neuropathic pain is a type of chronic pain that results from dysfunctions of the somatosensory nerve system. This study was aimed to investigate the effect of mTOR/VEGF signaling pathway on neuropathic pain and the regulation mechanisms of miR-183 on AMPA Receptors through mTOR/VEGF signaling pathway. METHODS: Chronic compress injury (CCI) model was constructed in the current study, we used paw withdrawal mechanic threshold (PWMT) and paw withdrawal thermal latency (PWTL) to observe mTOR and VEGF receptors...
January 18, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28212593/micrornas-and-endometriosis-distinguishing-drivers-from-passengers-in-disease-pathogenesis
#3
Warren B Nothnick
Endometriosis is a disease common in women of reproductive age, characterized by pelvic pain and infertility. Despite its prevalence, the factors and mechanisms which contribute to the development and survival of ectopic lesions remain uncertain. MicroRNAs (miRNAs) are small RNA molecules that regulate posttranscriptional gene regulation which have been proposed to contribute to the pathogenesis of many diseases including that of endometriosis. This review summarizes the results of initial studies describing differentially expressed miRNAs between endometriotic lesion tissue and eutopic endometrium...
February 17, 2017: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/28207662/expression-of-mirna-124a-in-cd4-cells-reflects-response-to-a-multidisciplinary-treatment-program-in-patients-with-chronic-low-back-pain
#4
Benjamin Luchting, Jens Heyn, Ludwig Christian Hinske, Shahnaz Christina Azad
STUDY DESIGN: A prospective evaluation of microRNA (miRNA) expression in patients with chronic low back pain (CLBP). OBJECTIVE: The aim of this study was to evaluate whether pain- and T cell-related miRNAs are differentially expressed in CLBP when compared with healthy volunteers and whether these miRNAs may distinguish between responders and nonresponders to a multidisciplinary treatment program. SUMMARY OF BACKGROUND DATA: CLBP is a common health problem worldwide...
February 15, 2017: Spine
https://www.readbyqxmd.com/read/28164636/diagnostic-and-prognostic-value-of-circulating-microrna-133a-in-patients-with-acute-myocardial-infarction
#5
Ling Yuan, Xiaoxiao Liu, Fang Chen, Lizhu Zhang, Xi Chen, Qiang Huang, Dan Wu, Chengjian Yang, Zhijun Han
BACKGROUND: The aim of this study was to examine the expression of circulating microRNA (miR)-133a in acute myocardial infarction (AMI) patients and assess its potential as a diagnostic and prognostic marker. METHODS: This study enrolled 222 consecutive patients who presented with chest pain symptoms suggestive of AMI in either the Department of Emergency or Department of Cardiology at Wuxi Second People's Hospital from October 2012 through December 2014. Of these, 102 were diagnosed with AMI and 120 with non-AMI chest pain...
July 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28162514/-282-sex-dependent-expression-of-microrna-19b-predicts-chronic-widespread-pain-and-posttraumatic-stress-disorder-development-following-trauma-exposure
#6
S Linnstaedt, A Wu, E Zimny, C Lewandowski, P Hendry, K Damiron, C Pearson, M Velilla, J Jones, R Swor, R Domeier, S McLean
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28161709/microrna-146a-ameliorates-inflammation-via-traf6-nf-%C3%AE%C2%BAb-pathway-in-intervertebral-disc-cells
#7
Feng Lv, Yingzi Huang, Wentao Lv, Longbiao Yang, Feng Li, Jingli Fan, Jianmin Sun
BACKGROUND Intervertebral disc degeneration (IDD) has been widely recognized as a major contributor to low back pain. Accumulating evidence suggests that IDD is linked to various pro-inflammatory cytokines and metabolites. Recently, numerous studies have demonstrated that microRNAs (miRNAs) play a pivotal role in the development of most disorders, including degenerative disc diseases. Previous reports have revealed that miRNA-146a (miR-146a) could attenuate neuropathic pain in the spinal cord. The aim of this study was to investigate the role of miR-146a in the inflammatory response of IDD...
February 5, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28135303/microrna-and-mrna-transcriptome-profiling-in-primary-human-astrocytes-infected-with-borrelia-burgdorferi
#8
Timothy Casselli, Humaira Qureshi, Elizabeth Peterson, Danielle Perley, Emily Blake, Bradley Jokinen, Ata Abbas, Sergei Nechaev, John A Watt, Archana Dhasarathy, Catherine A Brissette
Lyme disease is caused by infection with the bacterium Borrelia burgdorferi (Bb), which is transmitted to humans by deer ticks. The infection manifests usually as a rash and minor systemic symptoms; however, the bacteria can spread to other tissues, causing joint pain, carditis, and neurological symptoms. Lyme neuroborreliosis presents itself in several ways, such as Bell's palsy, meningitis, and encephalitis. The molecular basis for neuroborreliosis is poorly understood. Analysis of the changes in the expression levels of messenger RNAs and non-coding RNAs, including microRNAs, following Bb infection could therefore provide vital information on the pathogenesis and clinical symptoms of neuroborreliosis...
2017: PloS One
https://www.readbyqxmd.com/read/28130187/overexpression-of-mir-206-ameliorates-chronic-constriction-injury-induced-neuropathic-pain-in-rats-via-the-mek-erk-pathway-by-targeting-brain-derived-neurotrophic-factor
#9
Wenbo Sun, Limin Zhang, Rui Li
Neuropathic pain is chronic pain caused by lesions or diseases of the somatosensory system and existing tolerance to currently available analgesics. MicroRNAs (miRNAs) have been widely studied in the development of neuropathic pain and neuro-inflammation resulting from nerve injury. However, the precise mechanism of miRNAs involved in neuropathic pain remains largely unknown. In the present study, we investigated the vital roles of miR-206 and its putative target gene, brain-derived neurotrophic factor (BDNF), in neuropathic pain in the rat model of chronic constriction injury (CCI)...
January 24, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28127509/lentiviral-vector-encoded-microrna-based-shrna-mediated-gene-knockdown-of-n-methyl-d-aspartate-receptors-in-skin-reduces-pain
#10
Chien-Cheng Liu, Jiin-Tsuey Cheng, Kuo-Chuan Hung, Yuan-Yi Chia, Ping-Heng Tan
BACKGROUND AND PURPOSE: RNA polymerase II promoters that drive the expression of rationally designed primary microRNA-based shRNA, for example, shRNAmir, can produce more potent gene knockdown than RNA polymerase III promoters. Antagonists of peripheral N methyl-D-aspartate (NMDA) receptors that do not interfere with central glutamate processing would prevent the development of adverse central nervous system effects. Thus, in this study, we examined the effects of gene silencing and antinociception on formalin- and Complete Freund's adjuvant (CFA)-induced pain in rats by subcutaneously injecting a lentiviral vector encoding a shRNAmir that targets the NR1 subunit of the NMDA receptor...
January 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28114268/down-regulation-of-mirna-128-contributes-to-neuropathic-pain-following-spinal-cord-injury-via-activation-of-p38
#11
Zhaoyun Yang, Junmei Xu, Rong Zhu, Lei Liu
BACKGROUND Neuropathic pain (NPP) arises from a lesion or dysfunction of the somatosensory nervous system. Recent studies have demonstrated multiple microRNAs (miRNAs) play key roles in NPP development. This study aimed to investigate the effects of miR-128 on microglial cells. MATERIAL AND METHODS We established a compressive spinal cord injury (SCI) model and collected the spinal cord segment-derived conditioned medium (CM). We then measured the expression of miR-128 in the murine microglial cell line BV2 treated with CM-SCI or CM obtained from control (CM-NC)...
January 23, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28108674/effects-of-microrna-338-on-morphine-tolerance-by-targeting-cxcr4-in-a-rat-model-of-bone-cancer-pain
#12
Hong-Xia Mei, Min-Hong Zhou, Xing-Wang Zhang, Xi-Xi Huang, Yong-Le Wang, Pei-Fang Wang, Gong-Hao Zhan
This study aimed to investigate the effects of microRNA-338 (miR-338) on morphine tolerance through the targeting of CXCR4 in a rat model of bone cancer pain (BCP). Sprague Dawley rats were obtained and divided into model saline (n = 10), model morphine (n = 50), normal saline (n = 10) and normal morphine (healthy rats, n = 10) groups. After BCP rat model establishment, the remaining SD rats (n = 40) in the model saline group were assigned into pLV-THM-miR-338, pLV-THM-anti-miR-338, CXCR4 shRNA, blank and phosphate buffer saline (PBS) groups...
January 20, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28012171/mir-15b-mediates-oxaliplatin-induced-chronic-neuropathic-pain-through-bace1-down-regulation
#13
Naomi Ito, Atsushi Sakai, Noriko Miyake, Motoyo Maruyama, Hirotoshi Iwasaki, Koichi Miyake, Takashi Okada, Atsuhiro Sakamoto, Hidenori Suzuki
BACKGROUND AND PURPOSE: Although oxaliplatin is an effective anti-cancer platinum compound, it can cause painful chronic neuropathy, and its molecular mechanisms are poorly understood. MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression in a sequence-specific manner. Although miRNAs have been increasingly recognized as important modulators in a variety of pain conditions, their involvement in chemotherapy-induced neuropathic pain is unknown. EXPERIMENTAL APPROACH: Oxaliplatin-induced chronic neuropathic pain was induced in rats by i...
March 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28012097/mirna-expression-change-in-dorsal-root-ganglia-after-peripheral-nerve-injury
#14
Hsueh-Ling Chang, Hung-Chen Wang, Yi-Ta Chunag, Chao-Wen Chou, I-Ling Lin, Chung-Sheng Lai, Lin-Li Chang, Kuang-I Cheng
The role of microRNAs (miRNAs) in the regulation of nerve injury-induced neuropathic pain is unclear. The aims of this study were to assess and compare miRNA expression profiles in dorsal root ganglia (DRG) following three different kinds of peripheral nerve injury, including spinal nerve ligation (SNL), dorsal root transection (DRT), and ventral root transection (VRT), in Sprague-Dawley rats. Responses to thermal and mechanical stimuli were measured preoperatively and on postoperative days (PODs) 1, 4, and 7...
December 24, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27922111/mir-365-targets-%C3%AE-arrestin-2-to-reverse-morphine-tolerance-in-rats
#15
Jian Wang, Wei Xu, Tao Zhong, Zongbin Song, Yu Zou, Zhuofeng Ding, Qulian Guo, Xinzhong Dong, Wangyuan Zou
Morphine tolerance is a challenging clinical problem that limits its clinical application in pain treatment. Non-coding microRNAs (miRNAs) modulate gene expression in a post transcriptional manner, and their dysregulation causes various diseases. However, the significance of miRNAs in morphine tolerance is still poorly understood. In the present study, we hypothesized that microRNA-365 (miR-365) is a key functional small RNA that reverses morphine tolerance through regulation of β-arrestin 2 in rats. Here, microarray analysis and quantitative real-time PCR showed that miR-365 was robustly decreased in the spinal cord after chronic morphine administration...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27920341/serum-mir-451a-levels-are-significantly-elevated-in-women-with-endometriosis-and-recapitulated-in-baboons-papio-anubis-with-experimentally-induced-disease
#16
Warren B Nothnick, Tommaso Falcone, Niraj Joshi, Asgerally T Fazleabas, Amanda Graham
We have previously demonstrated that human microRNA-451a (miR-451a) endometriotic lesion expression is significantly higher compared to that of the corresponding eutopic endometrium. The objective of the current study was to examine the relationship between lesion and serum content of miR-451a and to determine the utility of serum miR-451a in distinguishing between women with and without visible signs of endometriosis. Eighty-one participants were enrolled in this study, 41 with confirmed endometriosis and 40 without visible signs of endometriosis at laparoscopy (n = 20) or symptoms of endometriosis (pain, infertility n = 20)...
December 5, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27917453/phase-i-study-of-mrx34-a-liposomal-mir-34a-mimic-administered-twice-weekly-in-patients-with-advanced-solid-tumors
#17
Muhammad S Beg, Andrew J Brenner, Jasgit Sachdev, Mitesh Borad, Yoon-Koo Kang, Jay Stoudemire, Susan Smith, Andreas G Bader, Sinil Kim, David S Hong
Purpose Naturally occurring tumor suppressor microRNA-34a (miR-34a) downregulates the expression of >30 oncogenes across multiple oncogenic pathways, as well as genes involved in tumor immune evasion, but is lost or under-expressed in many malignancies. This first-in-human, phase I study assessed the maximum tolerated dose (MTD), safety, pharmacokinetics, and clinical activity of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumors. Patients and Methods Adult patients with solid tumors refractory to standard treatment were enrolled in a standard 3 + 3 dose escalation trial...
December 5, 2016: Investigational New Drugs
https://www.readbyqxmd.com/read/27893432/microrna-34a-expression-levels-in-serum-and-intratumoral-tissue-can-predict-bone-metastasis-in-patients-with-hepatocellular-carcinoma
#18
Zuo-Lin Xiang, Xiao-Mei Zhao, Li Zhang, Ping Yang, Jia Fan, Zhao-You Tang, Zhao-Chong Zeng
Hepatocellular carcinoma (HCC) patients with bone metastasis (BM) suffer from pain and other symptoms that significantly reduce their quality of life. We screened a microRNA (miRNA) microarray to identify potential serum biomarkers for BM in HCC patients. A miRNA microarray was used to screen for BM-related miRNAs in paired serum samples from HCC patients with BM and from HCC patients without BM. Real-time quantitative polymerase chain reaction (qRT-PCR) was used to quantify candidate miRNAs in serum samples from 106 independent HCC patients...
November 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27805929/genetic-variant-rs3750625-in-the-3-utr-of-adra2a-affects-stress-dependent-acute-pain-severity-after-trauma-and-alters-a-microrna-34a-regulatory-site
#19
Sarah D Linnstaedt, Margaret G Walker, Kyle D Riker, Jennifer E Nyland, JunMei Hu, Catherine Rossi, Robert A Swor, Jeffrey S Jones, Luda Diatchenko, Andrey V Bortsov, David A Peak, Samuel A McLean
α2A adrenergic receptor (α2A-AR) activation has been shown in animal models to play an important role in regulating the balance of acute pain inhibition vs facilitation after both physical and psychological stress. To our knowledge, the influence of genetic variants in the gene encoding α2A-AR, ADRA2A, on acute pain outcomes in humans experiencing traumatic stress has not been assessed. In this study, we tested whether a genetic variant in the 3'UTR of ADRA2A, rs3750625, is associated with acute musculoskeletal pain (MSP) severity following motor vehicle collision (MVC, n = 948) and sexual assault (n = 84), and whether this influence was affected by stress severity...
February 2017: Pain
https://www.readbyqxmd.com/read/27770129/microrna-16-alleviates-inflammatory-pain-by-targeting-ras-related-protein-23-rab23-and-inhibiting-p38-mapk-activation
#20
Wenjin Chen, Shengdong Guo, Shenggang Wang
BACKGROUND The purpose of our study was to determine the functional role of microRNA (miR)-16 in chronic inflammatory pain and to disclose its underlying molecular mechanism. MATERIAL AND METHODS Inflammatory pain was induced by injection of complete Freund's adjuvant (CFA) to Wistar rats. The pWPXL-miR-16, PcDNA3.1- Ras-related protein (RAB23), and/or SB203580 were delivered intrathecally to the rats. Behavioral tests were detected at 0 h, 4 h, 1 d, 4 d, 7 d, and 14 d after CFA injection. After behavioral tests, L4-L6 dorsal spinal cord were obtained and the levels of miR-16, RAB23, and phosphorylation of p38 (p-p38) were evaluated by quantitative real-time PCR (qRT-PCR)...
October 22, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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