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Asim K. Duttaroy

Asim K Duttaroy
No abstract text is available yet for this article.
2016: Food & Nutrition Research
Niamh O'Kennedy, Daniel Raederstorff, Asim K Duttaroy
Hyperactive platelets, in addition to their roles in thrombosis, are also important mediators of atherogenesis. Antiplatelet drugs are not suitable for use where risk of a cardiovascular event is relatively low. It is therefore important to find alternative safe antiplatelet inhibitors for the vulnerable population who has hyperactive platelets in order to reduce the risk of cardiovascular disease. Potent antiplatelet factors were identified in water-soluble tomato extract (Fruitflow(®)), which significantly inhibited platelet aggregation...
July 7, 2016: European Journal of Nutrition
Abhilash D Pandya, Mrinal K Das, Arnab Sarkar, Srinivas Vilasagaram, Sanjay Basak, Asim K Duttaroy
The study aims to investigate whether cytosolic fatty acid-binding protein-4 (FABP4) is involved in angiogenic growth factors- and fatty acid-induced tube formation in first trimester placental trophoblast cells, HTR8/SVneo. We determined the tube formation both at basal as well as stimulated levels in the absence and presence of inhibitors of FABP4 and VEGF signaling pathways. Basal level of tube formation was maximally reduced in the presence of 50 µM of FABP4 inhibitor compared with those by VEGF signaling pathway inhibitors (rapamycin, L-NAME, and p38 MAP kinase inhibitor)...
June 2016: Cell Biology International
Sanjay Basak, Mrinal K Das, Vilasagar Srinivas, Asim K Duttaroy
The study aims to investigate the impacts of hyperglycemia in the presence of fatty acids on early placentation processes that involves tube formation, cellular growth and proliferation, and metabolic activities of the first trimester trophoblast cells. Effects of maternal circulatory glucose levels that mimic physiological (5.5 mM), pre-diabetic (11 mM) and diabetic (≥25 mM) phenotypes on tube formation (as a measure of angiogenesis in vitro), cellular viability and proliferation, fatty acid uptake and expression of genes associated with invasion, angiogenesis and fatty acid metabolism were examined using HTR8/SVneo cells...
March 2015: Molecular and Cellular Biochemistry
Mrinal K Das, Sanjay Basak, M Shakil Ahmed, Håvard Attramadal, Asim K Duttaroy
OBJECTIVES: To study the roles of connective tissue growth factor (CTGF) on tube formation (as a measure of cellular angiogenesis) and expression of angiogenesis-associated genes in first-trimester human extravillous trophoblast cells. STUDY DESIGN: The effects of recombinant human CTGF on tube forming ability were studied in the first trimester trophoblast cells using matrigel system. The expressions of genes involved in angiogenesis were studied using real time PCR microarray...
October 2014: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Dipankar Biswas, Md Main Uddin, Lili L Dizdarevic, Aud Jørgensen, Asim K Duttaroy
PURPOSE: To investigate the presence of anti-angiotensin converting enzyme (ACE) factors in aqueous extract of tomato. METHODS: The bio-guided fractionation of the aqueous extract of tomato produced a sugar-free, heat-stable fraction with molecular mass <1,000 Da from tomatoes. The sugar-free tomato extract (TE) was tested for its anti-ACE activity using human plasma and rabbit lung pure ACE. In addition, its effect on human platelet aggregation induced by ADP, collagen or arachidonic acid was determined...
December 2014: European Journal of Nutrition
Lili L Dizdarevic, Dipankar Biswas, M D Main Uddin, Aud Jørgenesen, Eva Falch, Nasser E Bastani, Asim K Duttaroy
Previous human studies suggest that supplementation with kiwifruits lowers several cardiovascular risk factors such as platelet hyperactivity, blood pressure and plasma lipids. The cardiovascular health benefit of fruit and vegetables is usually attributed to the complex mixture of phytochemicals therein; however, kiwifruit's cardioprotective factors are not well studied. In this study, we investigated the effects of kiwifruit extract on human blood platelet aggregation and plasma angiotensin-converting enzyme (ACE) activity...
2014: Platelets
Sanjay Basak, Mrinal K Das, Asim K Duttaroy
Angiogenesis is involved in the growth of new blood vessels from the existing one. Consequently, angiogenesis plays an indispensable role in tissue growth and repair including early placentation processes. Besides angiogenic growth factors (vascular endothelial growth factor (VEGF), angiopoietin-like 4 (ANGPTL4), placental growth factor (PlGF), platelet derived growth factor (PDGF), fibroblast growth factors (FGF)), dietary fatty acids (c>16) also directly or indirectly modulate angiogenic processes in tumors and other cell systems...
November 13, 2013: Life Sciences
Asim K Duttaroy
Beneficial effects of consumption of fruit and vegetables on the cardiovascular system have been reported. Fruit and vegetable components affect the cardiovascular system in both antioxidant and nonantioxidant ways. The mechanisms of their actions are, however, still not well understood. The compounds present in fruits and vegetables may function individually or in concert to protect lipoproteins and vascular cells from oxidation or by other mechanisms such as reducing plasma lipid levels, high blood pressure, and platelet hyperactivity...
2013: Advances in Food and Nutrition Research
Sanjay Basak, Asim K Duttaroy
A number of studies have been carried out to examine the biological function of conjugated linoleic acid (CLA) and its potential health benefits. However, not much is known about how CLA isomers mediate their effect on angiogenesis and vascularization during early placentation. In this paper we demonstrate that cis-9,trans-11(c9,t11)-CLA stimulated the expression of angiopoietin like-4 (ANGPTL4) mRNA and protein accompanied by tube formation in first trimester placental trophoblast cells, HTR8/SVneo whereas the other CLA isomer, trans-10,cis-12 (t10,c12)-CLA had no such effects...
April 2013: Biochimica et Biophysica Acta
Sanjay Basak, Asim K Duttaroy
Fatty acids regulate angiogenesis although no such information is available in first trimester placental trophoblast cells despite the fact that angiogenesis is a critical step involving these cells in early placentation. We investigated effects of different fatty acids on angiogenesis, their uptake and metabolism and expression of lipid metabolic genes in first trimester placental trophoblast cells using HTR-8/SVneo cell line. Fatty acid uptake by these cells exhibited a saturable kinetics. Uptake of AA was consistently greater compared with that of EPA and DHA throughout the incubation period of 180 min...
February 2013: Prostaglandins, Leukotrienes, and Essential Fatty Acids
Sanjay Basak, Asim K Duttaroy
OBJECTIVES: To study the roles of leptin on tube formation (as a measure of cellular angiogenesis) and expression of associated genes in first-trimester human extravillous trophoblast cells. STUDY DESIGN: The effects of leptin on tube formation and fatty acid uptake in first trimester extravillous placental trophoblast cells, HTR8/SVneo, were investigated. We also investigated the effects of leptin on the expression of genes involved in angiogenesis and lipid metabolism in these cells...
September 2012: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Anette Karlsen, Mette Svendsen, Ingebjørg Seljeflot, Mary-Ann Sommernes, Joseph Sexton, Asgeir Brevik, Iris Erlund, Mauro Serafini, Nasser Bastani, Siv Fagertun Remberg, Grethe I Borge, Monica Hauger Carlsen, Siv Kjølsrud Bøhn, Mari C Myhrstad, Lars O Dragsted, Asim K Duttaroy, Karin Haffner, Petter Laake, Christan A Drevon, Harald Arnesen, Andrew Collins, Serena Tonstad, Rune Blomhoff
It has been suggested that antioxidants attenuate oxidative stress and prevent oxidative stress-related diseases. Paradoxically, randomised controlled trials (RCT) using pharmacological doses of antioxidant supplements have demonstrated harmful effects in smokers. The aim of the present study was to test the compliance, tolerability and safety of two food-based antioxidant-rich diets in smokers. One of the diets provided antioxidants at levels similar to that used in RCT using supplements which previously have generated harmful effects...
August 2011: British Journal of Nutrition
Asgeir Brevik, Isabel Gaivão, Tirill Medin, Aud Jørgenesen, Anita Piasek, Johanna Elilasson, Anette Karlsen, Rune Blomhoff, Turid Veggan, Asim K Duttaroy, Andrew R Collins
BACKGROUND: The health positive effects of diets high in fruits and vegetables are generally not replicated in supplementation trials with isolated antioxidants and vitamins, and as a consequence the emphasis of chronic disease prevention has shifted to whole foods and whole food products. METHODS: We carried out a human intervention trial with the golden kiwifruit, Actinidia chinensis, measuring markers of antioxidant status, DNA stability, plasma lipids, and platelet aggregation...
2011: Nutrition Journal
Siv K Bøhn, Mari C Myhrstad, Magne Thoresen, Marit Holden, Anette Karlsen, Siv Haugen Tunheim, Iris Erlund, Mette Svendsen, Ingebjørg Seljeflot, Jan O Moskaug, Asim K Duttaroy, Petter Laake, Harald Arnesen, Serena Tonstad, Andrew Collins, Christan A Drevon, Rune Blomhoff
BACKGROUND: Plant-based diets rich in fruit and vegetables can prevent development of several chronic age-related diseases. However, the mechanisms behind this protective effect are not elucidated. We have tested the hypothesis that intake of antioxidant-rich foods can affect groups of genes associated with cellular stress defence in human blood cells. TRIAL REGISTRATION NUMBER: NCT00520819 METHODS: In an 8-week dietary intervention study, 102 healthy male smokers were randomised to either a diet rich in various antioxidant-rich foods, a kiwifruit diet (three kiwifruits/d added to the regular diet) or a control group...
2010: BMC Medicine
M Susanne Weedon-Fekjaer, Knut Tomas Dalen, Karianne Solaas, Anne Cathrine Staff, Asim K Duttaroy, Hilde Irene Nebb
Placental fatty acid transport and metabolism are important for proper growth and development of the feto-placental unit. The nuclear receptors, liver X receptors alpha and beta (LXRalpha and LXRbeta), are key regulators of lipid metabolism in many tissues, but little is known about their role in fatty acid transport and metabolism in placenta. The current study investigates the LXR-mediated regulation of long-chain acyl-CoA synthetase 3 (ACSL3) and its functions in human placental trophoblast cells. We demonstrate that activation of LXR increases ACSL3 expression, acyl-CoA synthetase activity, and fatty acid uptake in human tropholast cells...
July 2010: Journal of Lipid Research
Peter Szodoray, Ildiko F Horvath, Gabor Papp, Sandor Barath, Edit Gyimesi, Laszlo Csathy, Janos Kappelmayer, Sandor Sipka, Asim K Duttaroy, Britt Nakken, Margit Zeher
OBJECTIVE: The aim of the present study was to investigate the immunomodulating role of fat-soluble vitamins in 25 patients with primary SS (pSS) and 15 healthy individuals. METHODS: Plasma levels of vitamins A, D and E were determined by HPLC. Peripheral NK, NK T cells, T-cell subsets, B cells, IL-10 producing Tr1 cells, CD4(+)CD25(+) Treg cells and Th17 were determined by flow cytometry. Various Th1- and Th2-soluble cytokines were assessed by ELISA, whereas intracytoplasmic cytokines (IFN-gamma, IL-4, -10 and -17) were measured by flow cytometry...
February 2010: Rheumatology
Baljit Kaur, Aud Jørgensen, Asim K Duttaroy
In order to exert metabolic effects, fatty acids must be taken up by cells and metabolize effectively to different classes of cellular lipids (triacylglycerols, phospholipids, etc.) for incorporation into different cellular and intracellular compartments. Therefore, the main aim of the present study is to investigate the uptake and metabolism of fatty acids representing three different series of fatty acids such as oleic acid, 18:1n-9 (OA), arachidonic acid, 20:4n-6 (AA), and eicosapentaneoic acid, 20:5n-3 (EPA) by breast cancer cells, MDA-MB-231...
February 2009: Prostaglandins, Leukotrienes, and Essential Fatty Acids
Asim K Duttaroy
Essential fatty acids and their long chain polyunsaturated fatty acid derivatives (20C) such as docosahexaenoic and arachidonic acids are critical for proper fetal growth and development. Dietary intake as well as metabolism of these fatty acids, and their subsequent transfer from the mother to the fetus are therefore important requisites for developing fetus. The placenta is the key organ through which nutrients such as these fatty acids flow from the mother to the fetus. Cellular uptake and translocation of long chain fatty acids (LCFAs) in different tissues is achieved by a concert of co-existing mechanism...
January 2009: Progress in Lipid Research
Asim K Duttaroy, Tarun K Ray
No abstract text is available yet for this article.
June 2008: Current Opinion in Lipidology
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