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https://www.readbyqxmd.com/read/29141938/stimulation-of-the-sensory-pudendal-nerve-increases-bladder-capacity-in-the-rat
#1
James A Hokanson, Christopher L Langdale, Arun Sridhar, Warren M Grill
Pudendal nerve stimulation is a promising treatment approach for lower urinary tract dysfunction, including symptoms of overactive bladder. Despite some promising clinical studies, there remain many unknowns as to how best to stimulate the pudendal nerve to maximize therapeutic efficacy. We quantified changes in bladder capacity and voiding efficiency during single-fill cystometry in response to electrical stimulation of the sensory branch of the pudendal nerve in urethane-anesthetized female Wistar rats. Increases in bladder capacity were dependent on both stimulation amplitude and rate...
November 15, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29124347/the-effect-of-onabotulinumtoxina-according-to-site-of-injection-in-patients-with-overactive-bladder-a-systematic-review-and-meta-analysis
#2
Jung Ki Jo, Kyu Nam Kim, Dong Won Kim, Yong Tae Kim, Ji Yoon Kim, Ji Yeon Kim
PURPOSE: This study assessed the efficacy and safety of onabotulinumtoxinA according to injection site for treatment of overactive bladder. METHODS: A systematic literature review located randomized controlled trials of onabotulinumtoxinA treatment for neurogenic detrusor overactive bladder and idiopathic overactive bladder in adults. We searched MEDLINE, EMBASE, and the Cochrane Controlled Trials Register using the Ovid platform. Meta-analysis was based on Cochrane Review Methods...
November 9, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29104788/comparison-of-tamsulosin-and-silodosin-in-the-management-of-acute-urinary-retention-secondary-to-benign-prostatic-hyperplasia-in-patients-planned-for-trial-without-catheter-a-prospective-randomized-study
#3
Siddangouda B Patil, Kshitiz Ranka, Vinay S Kundargi, Nilesh Guru
Introduction: We present a prospective randomized study to compare the efficacy of tamsulosin and silodosin in patients suffering from acute urinary retention caused by benign prostatic hyperplasia, planned for trial without catheter. Material and methods: Patients with acute urinary retention secondary to benign prostatic hyperplasia (total 160) were catheterized and randomized into two groups: Group A: tamsulosin 0.4 mg (80 patients) and Group B: silodosin 8 mg (80 patients)...
2017: Central European Journal of Urology
https://www.readbyqxmd.com/read/29095516/three-month-primary-efficacy-data-for-the-success-trial-a-phase-iii-multi-center-prospective-randomized-controlled-study-treating-female-stress-urinary-incontinence-with-the-vesair-intravesical-balloon
#4
Kurt McCammon, Karny Jacoby, Susan Kalota, Jeffrey Snyder, Kevin Cline, Kaiser Robertson, Charles Rardin, Randall Kahan, Lonny Green, Jack Zuckerman, Eric Rovner
AIMS: The SUCCESS trial is a phase III study of the Vesair® balloon in the United States for female stress urinary incontinence (SUI). The purpose of this manuscript is to present the 3 month primary efficacy and tolerability outcome data. METHODS: The SUCCESS trial is a multi-center, prospective, single blind, randomized, sham-controlled study. Subjects were randomized on a 2.33:1 basis to either Vesair balloon placement or placebo. The primary efficacy endpoint was a composite of both a >50% reduction from baseline on 1 h provocative pad weight test and a ≥10-point improvement in symptoms on the Incontinence Quality of Life Survey (I-QOL) questionnaire assessed at the 3 month study visit...
November 2, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29095174/does-suprapubic-stimulation-in-infants-facilitate-collection-of-a-clean-catch-urine-specimen
#5
Shannon Hall-Million, Patricia Kunz Howard
Review of recent evidence with translation to practice for the advanced practice nurse (APN) role is presented using a case study module for "Faster Clean Catch Urine Collection (Quick Wee Method) From Infants: Randomised Controlled Trial." This prospective study enrolled 344 infants between 1 and 12 months of age seeking care in an emergency department with a complaint that led to the ordering of a clean catch urine specimen. Use of the Quick Wee procedure yielded clean catch urine specimens without the use of an invasive procedure...
October 2017: Advanced Emergency Nursing Journal
https://www.readbyqxmd.com/read/29094398/early-improvement-of-storage-or-voiding-symptoms-by-tadalafil-predicts-treatment-outcomes-in-patients-with-lower-urinary-tract-symptoms-from-benign-prostatic-hyperplasia
#6
Osamu Yokoyama, Akichika Ozeki, Nahoko Suzuki, Masahiro Murakami
OBJECTIVES: To determine whether early changes in International Prostate Symptom Score predict final improvement in the quality of life and treatment satisfaction of patients with lower urinary tract symptoms from benign prostatic hyperplasia receiving tadalafil. METHODS: This post-hoc analysis of three randomized-controlled trials of tadalafil for lower urinary tract symptoms from benign prostatic hyperplasia used subpopulations based on treatment status (tadalafil, placebo) and region (Japan, Asia)...
November 1, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29081762/a-comparison-of-relative-time-to-peak-and-tmax-for-mismatch-based-patient-selection
#7
Anke Wouters, Søren Christensen, Matus Straka, Michael Mlynash, John Liggins, Roland Bammer, Vincent Thijs, Robin Lemmens, Gregory W Albers, Maarten G Lansberg
BACKGROUND AND PURPOSE: The perfusion-weighted imaging (PWI)/diffusion-weighted imaging (DWI) mismatch profile is used to select patients for endovascular treatment. A PWI map of Tmax is commonly used to identify tissue with critical hypoperfusion. A time to peak (TTP) map reflects similar hemodynamic properties with the added benefit that it does not require arterial input function (AIF) selection and deconvolution. We aimed to determine if TTP could substitute Tmax for mismatch categorization...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29055129/desmopressin-for-treating-nocturia-in-men
#8
REVIEW
Julia Han, Jae Hung Jung, Caitlin J Bakker, Mark H Ebell, Philipp Dahm
BACKGROUND: Nocturia is the bothersome symptom of awakening one or more times per night to void. Desmopressin is a commonly used medication for treating nocturia. OBJECTIVES: To assess the effects of desmopressin as compared to other interventions in the treatment of nocturia in men. SEARCH METHODS: We performed a comprehensive search of medical literature with no restrictions on the language of publication or publication status. The date of the latest search of all databases was August 2017...
October 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29048257/desmopressin-acetate-nasal-spray-for-adults-with-nocturia
#9
Joshua A Cohn, Casey G Kowalik, W Stuart Reynolds, Melissa R Kaufman, Douglas F Milam, Roger R Dmochowski, Alan J Wein
Nocturia impacts 70% of individuals over age 70 years. Nocturnal polyuria is present in up to 88% of adults with nocturia, however, treatment options for reducing nighttime urine production have historically been limited to behavioral modification and off label use of timed diuretics and desmopressin. Noctiva(TM) (desmopressin acetate nasal spray, DANS, Serenity Pharmaceuticals, LLC) is a novel formulation of desmopressin approved by the Food and Drug Administration for the treatment of nocturia due to nocturnal polyuria in March 2017...
October 30, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/29036454/mirror-and-absence-of-counter-mirror-responses-to-action-sounds-measured-with-tms
#10
Luca F Ticini, Simone Schütz-Bosbach, Florian Waszak
To what extent is the mirror neuron mechanism malleable to experience? The answer to this question can help characterising its ontogeny and its role in social cognition. Some suggest that it develops through sensorimotor associations congruent with our own actions. Others argue for its extreme volatility that will encode any sensorimotor association in the environment. Here, we added to this debate by exploring the effects of short goal-directed "mirror" and "counter-mirror" trainings (a "mirror" training is defined as the first type of training encountered by the participants) on human auditory mirror motor-evoked potentials (MEPs)...
September 22, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29031769/intra-trigonal-onabotulinum-toxin-a-improves-bladder-symptoms-and-quality-of-life-in-bladder-pain-syndrome-interstitial-cystitis-patients-a-pilot-single-centre-randomized-double-blind-placebo-controlled-trial
#11
R Pinto, D Costa, A Morgado, P Pereira, A Charrua, J Silva, F Cruz
PURPOSE: To compare efficacy and safety of trigonal injections of onabotulinumtoxinA and saline in Bladder Pain Syndrome/Interstitial Cystitis patients. MATERIALS AND METHODS: This phase II study enrolled women with Bladder Pain Syndrome/Interstitial Cystitis >6months and pain ≥4 in 0-10 visual analogue scale, refractory to common treatment. OnabotulinumtoxinA 100U (n=10) or saline (placebo, n=9), were administered as 10 trigonal injections of 1ml. Primary end-point was change from baseline in pain intensity reported at week 12...
October 12, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28988782/predictors-of-genitourinary-malignancy-in-patients-with-asymptomatic-microscopic-hematuria
#12
Patrick Samson, Nikhil Waingankar, Paras Shah, Derek Friedman, Louis Kavoussi, Justin Han
OBJECTIVES: To report the incidence of genitourinary malignancy and identify associated risk factors in patients undergoing urologic evaluation for asymptomatic microscopic hematuria (AMH) according to the 2012 American Urologic Association guidelines. SUBJECTS/PATIENTS AND METHODS: A retrospective institutional review of patients who underwent evaluation for AMH between 2012 and 2015 was conducted. Covariates analyzed included age, sex, smoking status, history of other malignancy, history of pelvic irradiation, presence of irritative voiding symptoms, use of anticoagulation, number of red blood cells on microscopic urinalysis, and guideline adherence...
October 5, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28975069/the-analgesic-efficacy-of-intrathecal-bupivacaine-and-fentanyl-with-added-neostigmine-or-magnesium-sulphate
#13
Mehrdad Mokaram Dori, Farid Foruzin
BACKGROUND: An appropriate anesthesia duration with minimal side effects and prolonged postoperative analgesia are the ideal characteristics of an intrathecal drug used during spinal anesthesia. Neostigmine and magnesium sulphate have been used as spinal anesthetic additives with narcotics and local anesthetics. OBJECTIVES: This study aimed to assess the analgesic properties of intrathecal neostigmine and magnesium sulphate by adding them to intrathecal bupivacaine-fentanyl...
December 2016: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28974905/recent-advances-in-recurrent-urinary-tract-infection-from-pathogenesis-and-biomarkers-to-prevention
#14
REVIEW
Jia-Fong Jhang, Hann-Chorng Kuo
Recurrent urinary tract infection (UTI) might be one of the most common problems in urological clinics. Recent research has revealed novel evidence about recurrent UTI and it should be considered a different disease from the first infection. The pathogenesis of recurrent UTI might include two mechanisms, bacterial factors and deficiencies in host defense. Bacterial survival in the urinary bladder after antibiotic treatment and progression to form intracellular bacterial communities might be the most important bacterial factors...
July 2017: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/28956995/frequency-and-duration-of-fecal-shedding-of-salmonella-serovars-heidelberg-and-typhimurium-by-experimentally-infected-laying-hens-housed-in-enriched-colony-cages-at-different-stocking-densities
#15
Richard K Gast, Rupa Guraya, Deana R Jones, Jean Guard, Kenneth E Anderson, Darrin M Karcher
Eggs contaminated with Salmonella Enteritidis are leading sources of human salmonellosis, but Salmonella Heidelberg and Salmonella Typhimurium are also egg-associated pathogens. The management practices and housing facilities characterizing different systems for housing commercial egg flocks can influence Salmonella persistence and transmission. Animal welfare aspects of poultry housing have been widely debated, but their food safety ramifications are not thoroughly understood. The present study assessed the effects of two different bird stocking densities on the frequency and duration of fecal shedding of strains of Salmonella Heidelberg and Salmonella Typhimurium in groups of experimentally infected laying hens housed in colony cages enriched with perching and nesting areas...
September 2017: Avian Diseases
https://www.readbyqxmd.com/read/28954464/meta-analysis-of-the-efficacy-and-safety-of-mirabegron-add-on-therapy-to-solifenacin-for-overactive-bladder
#16
Yankai Xu, Ruihua Liu, Chu Liu, Yuanshan Cui, Zhenli Gao
PURPOSE: We performed a meta-analysis to evaluate the efficacy and safety of mirabegron add-on therapy to solifenacin for patients with overactive bladder (OAB). METHODS: We conducted a systematic literature review to identify all randomized, double-blind, controlled trials (RCTs) of this combination (mirabegron and solifenacin) for OAB. Embase, MEDLINE, and the Cochrane Central Register of Controlled Trials were searched. A manual search was also performed to investigate relevant references from the retrieved studies...
September 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28952690/-efficacy-of-tamsulosin-for-treating-lower-urinary-tract-symptoms-in-patients-with-advanced-prostate-cancer
#17
RANDOMIZED CONTROLLED TRIAL
A V Govorov, A O Vasilyev, D Yu Pushkar
RELEVANCE: From the moment of their first use to the present day, -adrenoblockers remain the most popular medication in urology. Indications for their clinical use for various pathological conditions are constantly expanding. AIM: To compare the efficacy of androgen deprivation therapy (ADT) alone and ADT with concomitant use of tamsulosin in treating lower urinary tract symptoms (LUTS), and to estimate the efficacy and safety of tamsulosin in relieving voiding dysfunction symptoms in patients with advanced PCa treated for 6 months...
September 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28941138/prolapse-surgery-with-or-without-incontinence-procedure-a-systematic-review-and-meta-analysis
#18
REVIEW
J Marinus van der Ploeg, Annemarie van der Steen, Sandra Zwolsman, C Huub van der Vaart, Jan-Paul W R Roovers
BACKGROUND: To reduce the risk of postoperative stress urinary incontinence (POSUI) prolapse repair might be combined with incontinence surgery. OBJECTIVES: Compare efficacy and safety of prolapse surgery with and without incontinence surgery. SEARCH STRATEGY: Including our earlier review a systematic search in PubMed, EMBASE, the Cochrane Library and the Register of Current Controlled Trials was performed from 1995 to 2017. SELECTION CRITERIA: Randomised trials comparing prolapse surgery with a midurethral sling (MUS) or Burch colposuspension...
September 22, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28929430/new-drugs-in-the-pipeline-for-the-treatment-of-hiv-a-review
#19
REVIEW
Leigh Anne Hylton Gravatt, Crystal R Leibrand, Sulay Patel, MaryPeace McRae
PURPOSE OF REVIEW: The purpose of this paper is to review therapies with new mechanisms of action for the treatment of HIV that are at least in phase 2 clinical trials. RECENT FINDINGS: There are several new mechanisms of action being represented within clinical development, including histone deacetylase (HDAC) inhibitors, gene therapies, broadly neutralizing anti-HIV antibodies, immune modulation, and drugs with new mechanisms to block HIV entry. The new therapies are being developed for both as add-on therapy to existing combination antiretroviral therapy and as agents to be used during treatment interruption...
September 19, 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28914701/elevated-postvoid-residual-urine-volume-identifying-risk-factors-and-predicting-resolution-in-women-with-pelvic-organ-prolapse
#20
Amanda Ulrich, Patricia Davis, Katie Propst, David M OʼSullivan, Paul Tulikangas
OBJECTIVES: This study aims to identify risk factors for elevated preoperative postvoid residual (PVR) and persistently elevated postoperative PVR and to evaluate the resolution rate of elevated PVR urine volume in patients undergoing reconstructive surgery for pelvic organ prolapse (POP). METHODS: This was a retrospective cohort study comparing 50 women with elevated preoperative PVR (≥100 mL) and 50 women with normal PVR (<100 mL). Preoperative demographic, physical examination, urodynamic data, type of surgery performed, and postoperative trial of void data were collected...
October 17, 2017: Female Pelvic Medicine & Reconstructive Surgery
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