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https://www.readbyqxmd.com/read/28299676/bioresorbable-scaffolds-for-coronary-stenosis-when-and-how-based-upon-current-studies
#1
REVIEW
Alexandre Abizaid, J Ribamar Costa
PURPOSE OF REVIEW: First-generation bioresorbable scaffolds (BRS), largely represented by the poly-l-lactic acid (PLLA) ABSORB (Abbott Vascular, Temecula, Illinois, US), have demonstrated, in low to moderate lesion complexity, similar efficacy to current generation metallic drug-eluting stents. However, a trend toward more device thrombosis has been observed, especially when the scaffolds are used in off-label situations. In this review, we address the most relevant drawbacks of these devices and, based on the available scientific data, we visit the scenarios where there is more uncertainty about their indication, trying to identify the lesions/patients to whom this technology should be voided at its current stage of development...
March 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28285395/two-techniques-for-assessing-postoperative-voiding-function-a-randomized-trial
#2
Erinn M Myers, Catherine A Matthews, Andrea K Crane, AnnaMarie Connolly, Jennifer M Wu, Elizabeth J Geller
INTRODUCTION AND HYPOTHESIS: Post-operative voiding dysfunction is common after sling placement and is assessed with a voiding trial (VT) before discharge. We hypothesized that an operating room (OR) initiated retrograde VT (OR-fill) would decrease time to discharge compared with a post-anesthesia care unit (PACU) initiated retrograde VT (PACU-fill). METHODS: This was a parallel non-blinded randomized trial, of women undergoing outpatient sling surgery at a university hospital...
March 11, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28277471/twenty-four-hour-voiding-diaries-versus-3-day-voiding-diaries-a-clinical-comparison
#3
Caroline Elmer, Amber Murphy, John O Elliott, Nicole M Book
OBJECTIVE: This study aimed to determine if 24-hour versus 3-day voiding diary affects medical decision making for women with urinary incontinence. METHODS: A retrospective chart review was conducted of patients presenting to the OhioHealth Urogynecology Physician group for urinary incontinence from 2009 to 2011. Practice protocol includes patient completion of a 3-day voiding diary before their appointment. Diagnostic and treatment plans were extracted based on the initial patient encounter and 3-day voiding diary...
March 9, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28277235/variation-in-the-level-of-detail-in-pediatric-voiding-cystourethrogram-reports
#4
Anthony J Schaeffer, Jeanne S Chow, Anastasia Ivanova, Gang Cui, Saul P Greenfield, J Michael Zerin, Alejandro Hoberman, Ranjiv I Mathews, Tej K Mattoo, Myra A Carpenter, Marva Moxey-Mims, Russell W Chesney, Caleb P Nelson
INTRODUCTION: Voiding cystourethrogram (VCUG) provides a wealth of data on urinary tract function and anatomy, but few standards exist for reporting VCUG findings. OBJECTIVE: We aimed to assess variability in VCUG reports and to test our hypothesis that VCUG reports from pediatric facilities and pediatric radiologists are more complete than those performed at other facilities or by non-pediatric radiologists. STUDY DESIGN: We analyzed original VCUG reports from children enrolled in the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) trial...
October 8, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28256100/uwin-urgency-weak-stream-incomplete-void-nocturia-score-for-assessment-of-lower-urinary-tract-symptoms-could-it-replace-the-american-urology-association-symptom-index-score-an-open-label-randomized-cross-over-trial
#5
Ashwin Mallya, Ramaiah Keshavamurthy, Vilvapathy S Karthikeyan, Sumit Kumar, Mahadevappa Nagabhushana, Ananth J Kamath
OBJECTIVE: The American Urology Association symptom index (AUASI) is the most accepted tool to assess lower urinary tract symptoms (LUTS). UWIN (urgency, weak stream, incomplete void, nocturia) score is a simplified questionnaire with fewer and more distinctive options omitting three questions from AUASI. We sought to identify if UWIN is equally efficient in capturing LUTS and could replace the gold-standard AUASI. METHODS: Consecutive consenting male patients with benign prostatic hyperplasia (BPH)-LUTS were randomized to receive either UWIN/AUASI questionnaire first followed by the other...
March 3, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28254462/fatty-acid-amide-hydrolase-inhibitor-treatment-in-men-with-chronic-prostatitis-chronic-pelvic-pain-syndrome-an-adaptive-double-blind-randomized-controlled-trial
#6
Florian M E Wagenlehner, J W Olivier van Till, Jos G A Houbiers, Reynaldo V Martina, Dirk P Cerneus, Joost H J M Melis, Antoni Majek, Egils Vjaters, Michael Urban, Henrikas Ramonas, Daniel A Shoskes, J Curtis Nickel
OBJECTIVE: To examine the effect of a peripherally active fatty acid amide hydrolase (FAAH) inhibitor ASP3652 on safety and efficacy outcomes in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Inhibition of FAAH is hypothesized to reduce the excitability of urinary tract afferents including nociceptors. MATERIALS AND METHODS: In this adaptive, randomized, double-blind, placebo-controlled study, adult male patients with moderate to severe CP/CPPS were treated for 12 weeks with an oral dose of ASP3652 (25, 75, 150, or 300 mg twice daily, or 300 mg once daily), or placebo...
February 27, 2017: Urology
https://www.readbyqxmd.com/read/28245906/definition-of-infection-after-fracture-fixation-a-systematic-review-of-randomized-controlled-trials-to-evaluate-current-practice
#7
REVIEW
W J Metsemakers, K Kortram, M Morgenstern, T F Moriarty, I Meex, R Kuehl, S Nijs, R G Richards, M Raschke, O Borens, S L Kates, C Zalavras, P V Giannoudis, M H J Verhofstad
INTRODUCTION: One of the most challenging musculoskeletal complications in modern trauma surgery is infection after fracture fixation (IAFF). Although infections are clinically obvious in many cases, a clear definition of the term IAFF is crucial, not only for the evaluation of published research data but also for the establishment of uniform treatment concepts. The aim of this systematic review was to identify the definitions used in the scientific literature to describe infectious complications after internal fixation of fractures...
February 20, 2017: Injury
https://www.readbyqxmd.com/read/28236604/using-prompted-voiding-to-manage-urinary-incontinence-in-nursing-homes-can-it-be-sustained
#8
Claudia K Y Lai, Xiaojuan Wan
OBJECTIVES: Studies reporting prompted voiding (PV) interventions were of short duration and were delivered by research personnel rather than nursing home staff. This study examined the effectiveness of the use of PV by nursing home staff in managing urinary incontinence among residents over a 6-month period. DESIGN: A randomized controlled trial. SETTING: Five nursing homes in Hong Kong. PARTICIPANTS: Data were collected from 52 nursing home residents who had been admitted to the facility for at least 6 months prior to the initiation of the study and whose incontinence had been stable over the 6-month period...
February 21, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28230566/the-effect-of-preoperative-phenazopyridine-on-urinary-retention-following-midurethral-sling
#9
Omar Felipe Dueñas-Garcia, Tania Sierra, Erica Nicasio, Katherine Leung, Cynthia D Hall, Michael K Flynn
OBJECTIVE: The aim of this study was to determine the effect of preoperative oral phenazopyridine on short-term voiding dysfunction in patients undergoing a retropubic midurethral sling. METHODS: We conducted a retrospective cohort study in subjects undergoing a retropubic midurethral sling comparing those who received preoperative oral phenazopyridine with those who did not. We included all women who underwent a retropubic midurethral sling without concomitant procedures under general anesthesia at our institution...
February 23, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28224714/urethral-sphincter-injection-of-botulinum-toxin-a-a-review-of-its-application-and-outcomes
#10
REVIEW
Jai Seth, Sophie Rintoul-Hoad, Arun Sahai
The first reported application of Botulinum toxin-A (BTX-A) into the urethral sphincter predates the first documented use in the bladder. The aim of this review is to describe the clinical indications of BTX-A injection into the urethral sphincter and its clinical efficacy. This review of the literature includes the larger more significant published studies that have reported on this use of BTX-A. Case reports and articles not published in English were excluded. There have been many published clinical studies describing the use of BTX-A in the urethral sphincter, four of which are randomized placebo controlled trials...
February 22, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28220200/intraurethral-bulking-agents-for-the-management-of-female-stress-urinary-incontinence-a-systematic-review
#11
REVIEW
Zain A Siddiqui, Hamid Abboudi, Ruairidh Crawford, Shahzad Shah
INTRODUCTION AND HYPOTHESIS: The object of this review was to assess the efficacy and safety of urethral bulking agents (UBA), principally Macroplastique and Bulkamid, in the treatment of female stress urinary incontinence (SUI). METHODS: MEDLINE® and EMBASE® databases were systematically searched up to June 2016. Year of publication, study type, outcome measures, urodynamics before and after the procedure, number of participants, procedure complications, proportion requiring repeat injections or surgical procedures, frequency of follow-up, and results were analysed...
February 21, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28215835/the-swedish-infant-high-grade-reflux-trial-uti-and-renal-damage
#12
Josefin Nordenström, Sofia Sjöström, Ulla Sillén, Rune Sixt, Per Brandström
INTRODUCTION: High-grade vesicoureteral reflux (VUR) in children is associated with recurrent urinary tract infection (UTI) and renal damage. Breakthrough UTI despite continuous antibiotic prophylaxis (CAP) during the first years of life is a matter of concern and evokes early intervention. We investigated whether early endoscopic treatment (ET) of VUR grade 4-5 can reduce the risk of UTI recurrence and renal scarring. MATERIALS AND METHODS: This prospective, randomized, controlled, multicentre, 1-year follow-up trial comprised 77 infants, <8 months of age with VUR grade 4-5 (Table) randomized to CAP (n = 39) or ET (with prophylaxis until resolution) (n = 38)...
February 2, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28202358/a-prospective-multicenter-double-blind-randomized-trial-of-bladder-instillation-of-liposome-formulation-onabotulinumtoxina-for-interstitial-cystitis-bladder-pain-syndrome
#13
Yao-Chi Chuang, Hann-Chorng Kuo
BACKGROUND: Intravesical instillation of liposomal-formulated botulinum toxin A (lipotoxin) has shown therapeutic effects on treatment of refractory overactive bladder without needle injections. We hereby assessed lipotoxin for the treatment of refractory interstitial cystitis/bladder pain syndrome (IC/BPS). METHODS: This two-center, double-blind, randomized, placebo-controlled physician-initiated study enrolled patients with refractory IC/BPS. The patients were assigned to intravesical instillation of lipotoxin (onabotulinumtoxinA 200 U with 80mg sphingomyelin) (n=31), onabotulinumtoxinA 200 U in normal saline (n=28), or normal saline alone (n=31)...
February 12, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28197031/efficacy-of-preprocedural-diclofenac-in-men-undergoing-double-j-stent-removal-under-local-anesthesia-a-double-blind-randomized-control-trial
#14
Vilvapathy Senguttuvan Karthikeyan, Ramaiah Keshavamurthy, Ashwin Mallya, Manohar Chikka Moga Siddaiah, Sumit Kumar, Chulai Rajabahadhur Chandrashekar
INTRODUCTION: Double J (DJ) stents are often removed under local anesthesia using a rigid cystoscope. Patients experience significant pain during this procedure and also continue to have discomfort during voiding for a few days. We assessed the efficacy and safety of preemptive oral diclofenac in pain relief in patients undergoing DJ stent removal (DJSR) by rigid cystoscopy compared to placebo. METHODS: Consecutive consenting male patients undergoing DJSR under local anesthesia between March 2014 and July 2015 were enrolled...
January 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28134806/systemic-immunotherapy-for-urothelial-cancer-current-trends-and-future-directions
#15
REVIEW
Shilpa Gupta, David Gill, Austin Poole, Neeraj Agarwal
Urothelial cancer of the bladder, renal pelvis, ureter, and other urinary organs is the fifth most common cancer in the United States, and systemic platinum-based chemotherapy remains the standard of care for first-line treatment of advanced/metastatic urothelial carcinoma (UC). Until recently, there were very limited options for patients who are refractory to chemotherapy, or do not tolerate chemotherapy due to toxicities and overall outcomes have remained very poor. While the role of immunotherapy was first established in non-muscle invasive bladder cancer in the 1970s, no systemic immunotherapy was approved for advanced disease until the recent approval of a programmed death ligand-1 (PD-L1) inhibitor, atezolizumab, in patients with advanced/metastatic UC who have progressed on platinum-containing regimens...
January 27, 2017: Cancers
https://www.readbyqxmd.com/read/28118174/modifiers-of-response-to-treatment-with-fesoterodine-for-urgency-predominant-urinary-incontinence-in-a-randomized-controlled-trial
#16
William D Winkelman, Alison J Huang, Michael Schembri, Rebecca G Rogers, Holly Richter, Deborah L Myers, Stephen R Kraus, Karen C Johnson, Rachel Hess, Tomas Gregory, Catherine S Bradley, Lily Arya, Janette S Brown, Leslee L Subak
OBJECTIVE: The aim of this study was to identify clinical and demographic characteristics that moderate response to treatment with fesoterodine among women with a diagnosis of urgency-predominant urinary incontinence. METHODS: A multicenter, double-blinded, 12-week randomized controlled trial of pharmacologic therapy for urgency-predominant urinary incontinence in community-dwelling women diagnosed by the 3-item Incontinence Questionnaire (3IQ) was previously performed...
March 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28113069/a-randomised-controlled-trial-comparing-immediate-versus-delayed-catheter-removal-following-vaginal-prolapse-surgery
#17
Rhiannon Bray, Rufus Cartwright, Alex Digesu, Ruwan Fernando, Vik Khullar
OBJECTIVE: It is unclear if any catheterisation is necessary after vaginal surgery for pelvic organ prolapse. The aim of this study was to determine if indwelling catheterisation is necessary after these procedures. STUDY DESIGN: A randomised controlled trial of immediate post-operative removal of catheter compared to a suprapubic catheter (SPC) after vaginal prolapse surgery. In the Suprapubic group the catheter was left on free drainage until a voiding trial was commenced at 48h...
January 15, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28107730/systemic-atherosclerosis-and-voiding-symptom
#18
A Ozgur Yeniel, A Mete Ergenoglu, Reci Meseri, Anıl Ari, Ceren Sancar, Ismail Mete Itil
OBJECTIVE: To evaluate the effect of atherosclerosis on the storage and voiding symptoms of the bladder in women with overactive bladder (OAB). STUDY DESIGN: We retrospectively reviewed the charts of women with OAB who were evaluated between 2013 and 2015 in our urogynecology unit. Charts were assessed for history, examination findings, urinary diary, quality of life (QOL) questionnaires, urodynamic studies (UDSs), and four main risk factors for atherosclerosis: hypertension, diabetes mellitus, smoking, and hyperlipidemia...
January 9, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28092069/treatment-of-concomitant-oab-and-bph
#19
REVIEW
Matthew C Moss, Tameem Rezan, Umar R Karaman, Alex Gomelsky
The etiology of men's lower urinary tract storage and voiding symptoms involves a contribution from both detrusor and outlet. As such, treatment of benign prostatic enlargement (BPE) ± benign prostatic obstruction (BPO) with standard alpha-adrenergic blockade and 5-alpha reductase inhibitor therapy may leave a population of men with persistent and bothersome urinary storage symptoms. An abundance of adequately powered, randomized, placebo-controlled trials indicate that the use of antimuscarinics and beta-3 adrenergic agonists, either alone or in combination with standard BPE/BPO therapy, leads to improvement in storage symptoms...
January 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28089606/parasacral-transcutaneous-electrical-neural-stimulation-ptens-once-a-week-for-the-treatment-of-overactive-bladder-in-children-a-randomized-controlled-trial
#20
Lidyanne Ilidia da Silva de Paula, Liliana Fajardo de Oliveira, Brysa Paiva Cruz, Dayana Maria de Oliveira, Laís Maini Miranda, Mauro de Moraes Ribeiro, Raphaela Ornellas Duque, André Avarese de Figueiredo, José de Bessa, José Murillo Bastos Netto
INTRODUCTION: Overactive bladder (OAB) is the most prevalent voiding disorder in childhood, and its main manifestation is urinary urgency. In general, urotherapy and anticholinergics are the first choices of treatment. Parasacral Transcutaneous Electrical Neural Stimulation (PTENS) was introduced as an alternative for the treatment of detrusor overactivity in children, but treatment protocols described to date require several sessions per week or long-lasting sessions, making it difficult for the child to adhere to the treatment...
December 21, 2016: Journal of Pediatric Urology
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