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https://www.readbyqxmd.com/read/29334338/at-home-genital-nerve-stimulation-for-individuals-with-sci-and-neurogenic-detrusor-overactivity-a-pilot-feasibility-study
#1
Dennis J Bourbeau, Kenneth J Gustafson, Steven W Brose
OBJECTIVE: Neurogenic bladder dysfunction, including neurogenic detrusor overactivity (NDO) is one of the most clinically significant problems for persons with spinal cord injury (SCI), affecting health and quality of life. Genital nerve stimulation (GNS) can acutely inhibit NDO-related reflex bladder contractions and increase bladder capacity. However, it is unknown if GNS can improve urinary continence or help meet individuals' bladder management goals during sustained use, which is required for GNS to be clinically effective...
January 15, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29331031/comparative-study-of-efficacy-and-safety-between-bladder-body-and-trigonal-intravesical-onabotulinumtoxina-injection-in-the-treatment-of-interstitial-cystitis-refractory-to-conventional-treatment-a-prospective-randomized-clinical-trial
#2
Yuan-Hong Jiang, Jia-Fong Jhang, Cheng-Ling Lee, Hann-Chorng Kuo
PURPOSE: Intravesical onabotulinumtoxinA (BoNT-A) injection can relieve symptoms of interstitial cystitis/bladder pain syndrome (IC/BPS). However, the therapeutic efficacy of different injection sites is not well known. This study compared therapeutic efficacy and safety between bladder body and trigonal BoNT-A injection. MATERIALS AND METHODS: Patients were randomly treated with 100U of BoNT-A in 10 mL saline injected into 20 bladder body sites or 10 trigonal sites...
January 13, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29324595/association-of-pharmacologic-treatment-of-urgency-urinary-incontinence-with-sleep-quality-and-daytime-sleepiness
#3
Qurratul A Warsi, Alison J Huang, Rachel Hess, Lily A Arya, Holly E Richter, Catherine S Bradley, Rebecca G Rogers, Deborah L Myers, Karen C Johnson, William D Winkelman, W Thomas Gregory, Stephen R Kraus, Michael Schembri, Jeanette S Brown, Katie L Stone, Leslee L Subak
OBJECTIVE: To evaluate the association between pharmacologic therapy for urgency urinary incontinence (UUI) and sleep quality. METHODS: We conducted a planned secondary data analysis of sleep outcomes in a previously conducted multicenter, double-blind, 12-week randomized trial of pharmacologic therapy for urgency-predominant incontinence among community-dwelling women self-diagnosed using the 3-Incontinence Questions questionnaire. Participants (N=645) were assigned randomly to 4-8 mg antimuscarinic therapy daily or placebo...
January 9, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29324518/the-dawn-of-liver-perfusion-machines
#4
Danielle Detelich, James F Markmann
PURPOSE OF REVIEW: Despite high demand, a severe shortage of suitable allografts limits the use of liver transplantation for the treatment of end-stage liver disease. The transplant community is turning to the utilization of high-risk grafts to fill the void. This review summarizes the reemergence of ex-vivo machine perfusion for liver graft preservation, including results of recent clinical trials and its specific role for reconditioning DCD, steatotic and elderly grafts. RECENT FINDINGS: Several phase-1 clinical trials demonstrate the safety and feasibility of machine perfusion for liver graft preservation...
January 9, 2018: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/29315785/three-month-clinical-results-with-a-rechargeable-sacral-neuromodulation-system-for-the-treatment-of-overactive-bladder
#5
Bertil Blok, Philip Van Kerrebroeck, Stefan de Wachter, Alain Ruffion, Frank Van der Aa, Ranjana Jairam, Marie Perrouin-Verbe, Sohier Elneil
AIMS: The primary aim of the RELAX-OAB study is to confirm the safety and efficacy of the Axonics r-SNM System, a miniaturized, rechargeable SNM system. METHODS: A total of 51 OAB patients were implanted in a single-stage implant procedure. These results represent the 3-month outcomes. Subject outcomes were evaluated using 3-day bladder diaries and quality of life questionnaires. RESULTS: A total of 31 of 34 patients (91%) that responded during an initial trial period ("Test Responders") continued to benefit from therapy with the Axonics r-SNM System at 3-months, defined as symptom improvement of ≥50% reduction in urinary voids or incontinence episodes or a return to <8 voids per day...
January 5, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29306350/effect-of-condensed-tannins-in-rations-of-lactating-dairy-cows-on-production-variables-and-nitrogen-use-efficiency
#6
K Gerlach, M Pries, E Tholen, A J Schmithausen, W Büscher, K-H Südekum
The objective of this study was to evaluate the effect of supplemented condensed tannins (CT) from the bark of the Black Wattle tree (Acacia mearnsii) on production variables and N use efficiency in high yielding dairy cows. A feeding trial with 96 lactating German Holstein cows was conducted for a total of 169 days, divided into four periods. The animals were allotted to two groups (control (CON) and experimental (EXP) group) according to milk yield in previous lactation, days in milk (98), number of lactations and BW...
January 8, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29300259/sleep-quality-and-daytime-sleepiness-among-women-with-urgency-predominant-urinary-incontinence
#7
William D Winkelman, Ann Warsi, Alison J Huang, Michael Schembri, Rebecca G Rogers, Holly E Richter, Deborah L Myers, Stephen R Kraus, Karen C Johnson, Rachel Hess, Thomas Gregory, Catherine S Bradley, Lily A Arya, Jeanette S Brown, Katie L Stone, Leslee L Subak
OBJECTIVE: The objective of this study was to examine the strength and direction of the association between urinary symptoms and both poor quality sleep and daytime sleepiness among women with urgency urinary incontinence. METHODS: A planned secondary analysis of baseline characteristics of participants in a multicenter, double-blinded, 12-week randomized controlled trial of pharmacologic therapy for urgency-predominant urinary incontinence in ambulatory women self-diagnosed by the 3 Incontinence Questions was performed...
January 3, 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29300256/randomized-controlled-trial-to-assess-the-impact-of-intraurethral-lidocaine-on-urodynamic-voiding-parameters
#8
Cassandra K Kisby, Eric J Gonzalez, Anthony G Visco, Cindy L Amundsen, Warren M Grill
OBJECTIVES: The aim of the study was to determine whether intraurethral anesthesia decreases voiding efficiency (VE; voided volume/(voided volume + residual volume)) and impacts other urodynamic parameters in healthy female volunteers during urodynamic studies. METHODS: This was a randomized double-blind placebo-controlled study of asymptomatic women aged 18 to 60 years. Subjects completed a visual analog scale and baseline questionnaires to assess pain and lower urinary tract symptoms, respectively...
January 3, 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29300254/postoperative-catheter-management-after-pelvic-reconstructive-surgery-a-survey-of-practice-strategies
#9
Sarah S Boyd, Elena Tunitsky-Bitton, David M OʼSullivan, Adam C Steinberg
OBJECTIVE: The aim of this study was to evaluate practice preferences in catheter management after a failed inpatient voiding trial after pelvic reconstructive surgery. METHODS: This is a cross-sectional study of postoperative catheter management after pelvic reconstructive surgery after failed voiding trial. Physicians practicing at ACGME-accredited residencies and fellowships in Obstetrics and Gynecology (Ob/Gyn), Urology, and Female Pelvic Medicine and Reconstructive Surgery (FPMRS) within the United States completed a Web-based questionnaire in March 2017...
January 3, 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29282207/risk-factors-for-the-development-of-bladder-and-bowel-dysfunction
#10
Thomas W Gaither, Christopher S Cooper, Zachary Kornberg, Laurence S Baskin, Hillary L Copp
BACKGROUND: Patients with vesicoureteral reflux and concomitant bladder and bowel dysfunction (BBD) are at high risk for febrile urinary tract infections. Risk factors for BBD have been identified in retrospective studies without validated measures. METHODS: We conducted a secondary analysis of the Randomized Intervention for Children with Vesicoureteral Reflux and Careful Urinary Tract Infection Evaluation trials. The outcome of interest in the analysis of these children was the development of BBD, defined by using the dysfunctional voiding questionnaire, during any time point in the studies...
December 27, 2017: Pediatrics
https://www.readbyqxmd.com/read/29234538/can-androgen-deprivation-therapy-obviate-the-need-of-channel-transurethral-resection-of-the-prostate-in-advanced-prostate-cancer-with-urinary-retention-a-prospective-study
#11
Rajeev Sood, Ritesh Kumar Singh, Hemant Goel, T Manasa, Nikhil Khattar, Mahesh C Tripathi
Objective: To evaluate the efficacy of androgen-deprivation therapy (ADT) in relieving urinary retention in patients with advanced prostate cancer presenting with urinary retention or a high post-void residual urine volume (PVR). Patients and methods: Patients with advanced prostate cancer with an indwelling catheter for acute/chronic urinary retention, or with a high PVR (>200 mL) who had not received any previous treatment were included in the study. Patients with localised prostate cancer eligible for receiving any therapy aimed at cure were excluded...
December 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29215517/two-year-results-of-burch-compared-with-midurethral-sling-with-sacrocolpopexy-a-randomized-controlled-trial
#12
Emanuel C Trabuco, Brian J Linder, Christopher J Klingele, Roberta E Blandon, John A Occhino, Amy L Weaver, Michaela E McGree, John B Gebhart
OBJECTIVE: To evaluate 1- and 2-year urinary continence rates after Burch retropubic urethropexy compared with a retropubic midurethral sling for women with urinary incontinence undergoing sacrocolpopexy. METHODS: We conducted a planned secondary analysis of a multicenter, randomized, single-blind trial comparing Burch with a sling that enrolled participants from June 2009 to August 2013. Objective outcome measures of continence were assessed at 1- and 2-year follow-up through office visits and validated questionnaires...
December 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29214638/harnessing-the-power-of-real-world-evidence-rwe-a-checklist-to-ensure-regulatory-grade-data-quality
#13
Rebecca A Miksad, Amy P Abernethy
The role of real-world evidence (RWE) in regulatory, drug development, and healthcare decision-making is rapidly expanding. Recent advances have increased the complexity of cancer care and widened the gap between randomized clinical trial (RCT) results and the evidence needed for real-world clinical decisions. Instead of remaining invisible, data from the >95% of cancer patients treated outside of clinical trials can help fill this void.
December 6, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29205506/systematic-review-and-meta-analysis-on-the-efficacy-and-tolerability-of-mirabegron-for-the-treatment-of-storage-lower-urinary-tract-symptoms-overactive-bladder-comparison-with-placebo-and-tolterodine
#14
REVIEW
Arcangelo Sebastianelli, Giorgio I Russo, Steven A Kaplan, Kevin T McVary, Ignacio Moncada, Stavros Gravas, Christopher Chapple, Giuseppe Morgia, Sergio Serni, Mauro Gacci
A systematic review and meta-analysis was carried out to evaluate the efficacy and safety of mirabegron 50 mg and 100 mg in the treatment of storage lower urinary tract symptoms/overactive bladder in comparison with a placebo and tolterodine 4 mg. A total of 491 articles were collected and eight randomized studies were identified as eligible for this meta-analysis. Overall, eight trials were included in the meta-analysis evaluating 10 248 patients. Mirabegron at both doses of 50 mg and 100 mg, and and tolterodine 4 mg were significantly associated with the reduction of incontinence episodes per 24 h, reduction of mean number of micturitions per 24 h, increase of voided volume and reduction of urgency episodes per 24 h, compared to a placebo...
December 3, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29197315/commentary-on-improving-postoperative-efficiency-an-algorithm-for-expedited-void-trials-after-urogynecologic-surgery
#15
Stephen A Metz
No abstract text is available yet for this article.
December 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/29197314/improving-postoperative-efficiency-an-algorithm-for-expedited-void-trials-after-urogynecologic-surgery
#16
A Rebecca Meekins, Nazema Y Siddiqui, Cindy L Amundsen, Maragatha Kuchibhatla, Alexis A Dieter
OBJECTIVES: To evaluate the relation between voided volume and void trial "success" to create an algorithm that minimizes the need for postvoid residual volume (PVR) assessment in backfill-assisted void trials. METHODS: This article is an ancillary analysis of deidentified data from a randomized trial evaluating prophylactic antibiotics after urogynecologic surgery. Void trials were routinely performed after surgery; voided volumes, PVR, and void trial outcomes were collected...
December 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/29191471/nerve-sparing-approach-improves-outcomes-of-patients-undergoing-minimally-invasive-radical-hysterectomy-a-systematic-review-and-meta-analysis
#17
REVIEW
Giorgio Bogani, Diego Oreste Rossetti, Antonino Ditto, Mauro Signorelli, Fabio Martinelli, Lavinia Mosca, Cono Scaffa, Umberto Leone Roberti Maggiore, Valentina Chiappa, Ilaria Sabatucci, Domenica Lorusso, Francesco Raspagliesi
Few studies investigated the efficacy and safety of nerve sparing approach via minimally invasive surgery for the treatment of cervical cancer. We aimed to review the current evidence comparing nerve sparing minimally invasive radical hysterectomy (NS-MRH) and conventional minimally invasive radical hysterectomy (MRH). This systematic review was registered in the International Prospective Register of Systematic Reviews (CRD#57655). Overall, 675 patients were included: 350 (51.9%) and 325 (48.1%) patients undergoing MRH and NS-MRH, respectively...
November 27, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29181582/contrast-enhanced-voiding-urosonography-cevus-with-the-intravesical-administration-of-the-ultrasound-contrast-agent-optison%C3%A2-for-vesicoureteral-reflux-detection-in-children-a-prospective-clinical-trial
#18
Aikaterini Ntoulia, Susan J Back, Sphoorti Shellikeri, Laura Poznick, Trudy Morgan, Joanne Kerwood, J Christopher Edgar, Richard D Bellah, Janet R Reid, Diego Jaramillo, Douglas A Canning, Kassa Darge
BACKGROUND: Contrast-enhanced voiding urosonography (ceVUS) is widely used outside the United States to diagnose vesicoureteral reflux (VUR) in children and is highly sensitive while avoiding exposure to ionizing radiation. At the onset of this study, two ultrasound (US) contrast agents were available in the United States. Pediatric safety data for intravenous administration was published for one, Optison™. OBJECTIVE: This study aimed to evaluate the diagnostic performance and safety of ceVUS using Optison™ and compare its diagnostic efficacy with voiding cystourethrogram (VCUG) for VUR detection and grading in children...
November 27, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29160004/urological-dysfunction-in-young-women-an-inheritance-of-childhood
#19
Elisabetta Costantini, Ester Illiano, Konstantinos Giannitsas, Marco Prestipino, Antonio Luigi Pastore, Antonio Carbone, Giovanni Palleschi, Raffaele Balsamo, Franca Natale, Donata Villari, Vittorio Bini, Serena Maruccia, Maria-Teresa Filocamo, Alessandro Zucchi
OBJECTIVE: To investigate the correlation of a history of lower urinary tract symptomatology during childhood with lower urinary tract dysfunction in young adult women. SUBJECTS AND METHODS: This was a multicentre, prospective, case-control study conducted between April 2013 and November 2015. A total of 300 women, aged 18-40 years, participated. The case group comprised women attending urogynaecology clinics for various lower urinary tract complaints and the control group was recruited from a healthy population...
November 21, 2017: BJU International
https://www.readbyqxmd.com/read/29150394/efficacy-of-prostatic-artery-embolization-for-catheter-dependent-patients-with-large-prostate-sizes-and-high-comorbidity-scores
#20
Shivank Bhatia, Vishal K Sinha, Bruce R Kava, Christopher Gomez, Sardis Harward, Sanoj Punnen, Issam Kably, Jeffrey Miller, Dipen J Parekh
PURPOSE: To evaluate efficacy and safety of prostate artery embolization (PAE) in urinary catheter-dependent patients with large prostate volumes and high comorbidity scores. MATERIALS AND METHODS: A retrospective single-center review was conducted of 30 patients with urinary retention at time of PAE from November 2014 through February 2017. Mean (range) age was 73.1 years (48-94 y), age-adjusted Charlson comorbidity index was 4.5 (0-10), duration of urinary retention was 63...
January 2018: Journal of Vascular and Interventional Radiology: JVIR
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