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https://www.readbyqxmd.com/read/27896711/using-eq-5d-3l-and-oab-5d-to-assess-changes-in-the-health-related-quality-of-life-of-men-with-lower-urinary-tract-symptoms-associated-with-benign-prostatic-hyperplasia
#1
Zalmai Hakimi, Mike Herdman, Marco Pavesi, Nancy Devlin, Jameel Nazir, Chris Hoyle, Isaac A O Odeyemi
OBJECTIVES: To assess changes in the health status of men with lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH) using the EQ-5D-3L and OAB-5D instruments and to evaluate the sensitivity of the instruments. METHODS: Data were available from a large randomised phase III trial of men with moderate-to-severe storage and voiding LUTS/BPH (NEPTUNE). Men received a fixed-dose combination of solifenacin 6 mg plus oral controlled absorption system (OCAS™) formulation of tamsulosin (TOCAS, 0...
November 28, 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27896579/prostatic-artery-embolization-in-treating-benign-prostatic-hyperplasia-a-systematic-review
#2
Jeremy Y C Teoh, Peter K F Chiu, Chi-Hang Yee, Hon-Ming Wong, Chi-Kwok Chan, Eddie S Y Chan, Simon S M Hou, Chi-Fai Ng
INTRODUCTION: We systemically reviewed the current evidence on prostatic artery embolization (PAE) in treating men with benign prostatic hyperplasia. METHODS: A systemic literature search was conducted in PubMed, EMBASE and Web of Science on 1 May 2016 without time constraints. Outcomes of interest included the changes in the International Prostate Symptom Score (IPSS), quality-of-life (QOL) score, peak urinary flow (Qmax), post-void residual urine (PVR), International Index of Erectile Function (IIEF) score, prostate volume (PV) and prostate-specific antigen (PSA) level...
November 28, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27892594/chloroprocaine-10-mg-ml-for-low-dose-spinal-anaesthesia-in-perianal-surgery-a-randomised-dose-finding-study
#3
V Gebhardt, L Mueller-Hansen, A Schwarz, D Bussen, C Weiss, M D Schmittner
BACKGROUND: Low-dose spinal anaesthesia is a safe and reliable anaesthesia technique in outpatient perianal surgery. Regarding its short duration of action and its trend to hyperbaric characteristics, plain chloroprocaine 10 mg/ml seems to be ideal to perform low-dose spinal anaesthesia. The aim of this trial was to determine the optimal dosage of chloroprocaine for this indication. METHODS: Hundred and twenty patients undergoing perianal surgery were enrolled and randomly allocated to receive 10, 20 or 30 mg of chloroprocaine 10 mg/ml intrathecally...
November 28, 2016: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/27889221/the-swedish-infant-high-grade-reflux-trial-study-presentation-and-vesicoureteral-reflux-outcome
#4
Josefin Nordenström, Gundela Holmdahl, Per Brandström, Rune Sixt, Eira Stokland, Ulla Sillén, Sofia Sjöström
INTRODUCTION: High-grade vesicoureteral reflux (VUR) in infants is associated with congenital renal abnormalities, recurrent UTI, and bladder dysfunction. Endoscopic treatment (ET) is a well-established method in children with low to moderate reflux grades, but there is a lack of randomised controlled trials regarding the use of ET versus continuous antibiotic prophylaxis in infants with high-grade VUR. OBJECTIVE: This study aimed to determine whether high-grade VUR in infants can be treated with endoscopic injection and whether ET is superior to antibiotic prophylaxis in the treatment of VUR...
October 24, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27889217/the-sight-questionnaire-a-novel-assessment-tool-for-satisfaction-in-genital-hypospadias-treatment
#5
Peter U Ardelt, Marco Cederqvist, Michael Barth, Alexander Frankenschmidt
PURPOSE: Psychosexual development is currently underrepresented in hypospadias outcome research. The aim of this study was to develop and validate a questionnaire addressing psychosexual long-term satisfaction, specifically of adolescent patients, after hypospadias repair. MATERIALS AND METHODS: In a multistep participative design we identified key interests of adolescent patients with hypospadias. Next, a questionnaire addressing specifically the psychosexual satisfaction of adolescents after hypospadias repair was established...
November 15, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27869312/the-effect-of-emg-biofeedback-assisted-pelvic-floor-muscle-therapy-on-symptoms-of-the-overactive-bladder-syndrome-in-women-a-randomized-controlled-trial
#6
Jeroen C Voorham, Stefan De Wachter, Tine W L Van den Bos, Hein Putter, Guus A Lycklama À Nijeholt, Petra J Voorham-van der Zalm
AIMS: The overactive bladder syndrome (OAB) is defined as urinary urgency, usually accompanied by frequency and nocturia, with or without urgency urinary incontinence. Biofeedback-assisted pelvic muscle therapy (BAPFMT) is a first-line treatment option for OAB. The aims of this study were to determine the efficacy and effectiveness of BAPFMT on symptoms of OAB after 9 weeks of treatment and to detect changes EMG activity of individual pelvic floor muscles (PFM) with the MAPLe. METHODS: Patients were randomly divided into an intervention group that received BAPFMT with the MAPLe or into a control group which received only toilet behavior and lifestyle instructions...
November 21, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27862666/filling-the-void-enriching-the-feature-space-of-successful-stopping
#7
René J Huster, Signe Schneider, Christina F Lavallee, Stefanie Enriquez-Geppert, Christoph S Herrmann
The ability to inhibit behavior is crucial for adaptation in a fast changing environment and is commonly studied with the stop signal task. Current EEG research mainly focuses on the N200 and P300 ERPs and corresponding activity in the theta and delta frequency range, thereby leaving us with a limited understanding of the mechanisms of response inhibition. Here, 15 functional networks were estimated from time-frequency transformed EEG recorded during processing of a visual stop signal task. Cortical sources underlying these functional networks were reconstructed, and a total of 45 features, each representing spectrally and temporally coherent activity, were extracted to train a classifier to differentiate between go and stop trials...
November 11, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27845955/incidence-of-bladder-injury-during-retropubic-midurethral-sling-placement-after-prior-burch-colpopexy
#8
Laura Faye Gephart, Thomas J Kuehl, Michelle Reyes, Paul M Yandell, Wilma I Larsen
OBJECTIVES: To elucidate if prior Burch changes the risk of bladder injury or rates of voiding dysfunction and continence in the immediate postoperative period when undergoing retropubic midurethral sling (MUS) placement. METHODS: In this retrospective case control, charts were selected by Current Procedural Terminology codes for MUS placement. Women undergoing retropubic MUS placement with history of Burch urethropexy were considered. For every case, 2 age-matched and parity-matched controls without prior Burch were selected...
November 10, 2016: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/27845219/efficacy-of-daily-low-dose-tadalafil-for-treating-overactive-bladder-results-of-a-randomized-double-blind-placebo-controlled-trial
#9
Hongde Chen, Feng Wang, Zhixian Yu, Yirong Zhang, Chaohui Liu, Shengjie Dai, Bicheng Chen, Jiaju Lv
OBJECTIVES: To evaluate the efficacy of daily low-dose tadalafil therapy for overactive bladder (OAB) in women. PATIENTS AND METHODS: A total of 96 women with idiopathic OAB from three medical centers in the south of Zhejiang Province of China were randomly assigned to treatment with daily low-dose tadalafil (5 mg, n=48) or placebo (n=48) for 3 months. The Indevus urgency severity scale (IUSS), overactive bladder symptom score (OABSS),([2]) and a 3-day micturition diary with frequency, incontinence, and urgency episodes were recorded and compared before the treatment, every 2 weeks following the treatment, and 3 months after the treatment...
November 11, 2016: Urology
https://www.readbyqxmd.com/read/27792298/potential-primary-endpoint-for-exploratory-clinical-trial-in-patients-with-overactive-bladder-a-systematic-literature-review
#10
Shingo Iino, Masayuki Kaneko, Mamoru Narukawa
OBJECTIVES: To identify a potential primary endpoint in an early-phase exploratory trial among key overactive bladder (OAB) symptoms. METHODS: Placebo-controlled double-blinding trials in patients with OAB were extracted for systematic literature review. The correlation between key OAB symptoms recorded in bladder diaries and coefficient of variation (CV) in each study were assessed. RESULTS: Forty-one controlled trials were extracted for the present review...
October 28, 2016: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/27785470/monitoring-of-spine-curvatures-and-posture-during-pregnancy-using-surface-topography-case-study-and-suggestion-of-method
#11
Jakub Michoński, Katarzyna Walesiak, Anna Pakuła, Wojciech Glinkowski, Robert Sitnik
BACKGROUND: Low back and pelvic pain is one of the most frequently reported disorders in pregnancy, however etiology and pathology of this problem have not been fully determined. The relationship between back pain experienced during pregnancy and posture remains unclear. It is challenging to measure reliably postural and spinal changes at the time of pregnancy, since most imaging studies cannot be used due to the radiation burden. 3D shape measurement, or surface topography (ST), systems designed for posture evaluation could potentially fill this void...
2016: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/27742102/smartphone-technology-facilitates-dietary-change-in-healthy-adults
#12
Michelle L Ipjian, Carol S Johnston
OBJECTIVES: Many individuals are advised to adhere to specific diet plans for their personal health; hence, it is important that tools are available to support these behaviors. Smartphone applications (apps) may assist health care professionals in educating their clients on specific dietary modifications. This pilot study focused on a single dietary modification, reducing sodium intake, to determine whether a commercial health app is useful for promoting dietary change. METHODS: Thirty healthy adults (age 34...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27737513/pharmacologic-interventions-for-treating-phantom-limb-pain
#13
REVIEW
Maria Jenelyn M Alviar, Tom Hale, Monalisa Dungca
BACKGROUND: This is an updated version of the original Cochrane review published in Issue 12, 2011. Phantom limb pain (PLP) is pain that arises in the missing limb after amputation and can be severe, intractable, and disabling. Various medications have been studied in the treatment of phantom pain. There is currently uncertainty in the optimal pharmacologic management of PLP. OBJECTIVES: This review aimed to summarise the evidence of effectiveness of pharmacologic interventions in treating PLP...
October 14, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27713802/the-role-of-voiding-cystourethrography-in-the-investigation-of-children-with-urinary-tract-infections
#14
Linda C Lee, Armando J Lorenzo, Martin A Koyle
Urinary tract infections (UTIs) represent a common bacterial cause of febrile illness in children. Of children presenting with a febrile UTI, 25-40% are found to have vesicoureteral reflux (VUR). Historically, the concern regarding VUR was that it could lead to recurrent pyelonephritis, renal scarring, hypertension, and chronic kidney disease. As a result, many children underwent invasive surgical procedures to correct VUR. We now know that many cases of VUR are low-grade and have a high rate of spontaneous resolution...
May 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27712641/anorectal-and-pelvic-pain
#15
REVIEW
Adil E Bharucha, Tae Hee Lee
Although pelvic pain is a symptom of several structural anorectal and pelvic disorders (eg, anal fissure, endometriosis, and pelvic inflammatory disease), this comprehensive review will focus on the 3 most common nonstructural, or functional, disorders associated with pelvic pain: functional anorectal pain (ie, levator ani syndrome, unspecified anorectal pain, and proctalgia fugax), interstitial cystitis/bladder pain syndrome, and chronic prostatitis/chronic pelvic pain syndrome. The first 2 conditions occur in both sexes, while the latter occurs only in men...
October 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27706012/sacral-neuromodulation-in-patients-with-a-cardiac-pacemaker
#16
Abdullah A Gahzi, Dean S Elterman, Magdy Hassouna
The objective of this study was to describe our experience using sacral neuromodulation to treat urinary urgency, frequency, urge incontinence, and chronic urinary retention in patients with cardiac pacemakers. With the increasingly widespread use of InterStim for bladder function restoration, we are seeing more complex patients with multiple comorbidities, including cardiac conditions. Herein, we report 3 cases of individuals with cardiac pacemakers who underwent InterStim implantation to treat urinary conditions...
September 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27698559/efficacy-and-safety-of-tamsulosin-hydrochloride-0-2-mg-and-combination-of-tamsulosin-hydrochloride-0-2-mg-plus-solifenacin-succinate-5-mg-after-transurethral-resection-of-the-prostate-a-prospective-randomized-controlled-trial
#17
Yu Seob Shin, Li Tao Zhang, Jae Hyung You, In Sung Choi, Chen Zhao, Jong Kwan Park
OBJECTIVE: The objective of this study was to evaluate the safety and efficacy of tamsulosin hydrochloride 0.2 mg (TAM) and its combination with solifenacin succinate 5 mg (SOL) after transurethral resection of the prostate (TURP). PATIENTS AND METHODS: The patients were randomized into three groups: TURP (group 1), TURP plus TAM (group 2), and TURP plus TAM + SOL (group 3). Patients in group 2 and group 3 received medication for 4 weeks. The primary efficacy end points were the mean change in total International Prostate Symptom Score (IPSS) and IPSS subscores...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27698548/bio-adaption-between-magnesium-alloy-stent-and-the-blood-vessel-a-review
#18
Jun Ma, Nan Zhao, Lexxus Betts, Donghui Zhu
Biodegradable magnesium (Mg) alloy stents are the most promising next generation of bio-absorbable stents. In this article, we summarized the progresses on the in vitro studies, animal testing and clinical trials of biodegradable Mg alloy stents in the past decades. These exciting findings led us to propose the importance of the concept "bio-adaption" between the Mg alloy stent and the local tissue microenvironment after implantation. The healing responses of stented blood vessel can be generally described in three overlapping phases: inflammation, granulation and remodeling...
September 2016: Journal of Materials Science & Technology
https://www.readbyqxmd.com/read/27688751/novel-bioceramic-urethral-bulking-agents-elicit-improved-host-tissue-responses-in-a-rat-model
#19
Travis K Mann-Gow, Benjamin J King, Ahmed El-Ghannam, Christine Knabe-Ducheyne, Masatoshi Kida, Ole M Dall, Jan Krhut, Peter Zvara
Objectives. To test the physical properties and host response to the bioceramic particles, silica-calcium phosphate (SCPC10) and Cristobalite, in a rat animal model and compare their biocompatibility to the current clinically utilized urethral bulking materials. Material and Methods. The novel bulking materials, SCPC10 and Cristobalite, were suspended in hyaluronic acid sodium salt and injected into the mid urethra of a rat. Additional animals were injected with bulking materials currently in clinical use. Physiological response was assessed using voiding trials, and host tissue response was evaluated using hard tissue histology and immunohistochemical analysis...
2016: Advances in Urology
https://www.readbyqxmd.com/read/27687820/solifenacin-in-children-and-adolescents-with-overactive-bladder-results-of-a-phase-3-randomised-clinical-trial
#20
Donald Newgreen, Brigitte Bosman, Adriana Hollestein-Havelaar, Ellen Dahler, Robin Besuyen, Will Sawyer, Stéphane Bolduc, Søren Rittig
BACKGROUND: Solifenacin, an effective, well-tolerated treatment for adult overactive bladder (OAB) symptoms, has not been evaluated in placebo-controlled paediatric clinical trials. OBJECTIVES: To evaluate the efficacy and safety of once-daily oral solifenacin suspension in OAB patients aged 5-<12 yr (children) and 12-<18 yr (adolescents). DESIGN, SETTING, AND PARTICIPANTS: The study involved a 4-wk urotherapy run-in followed by 1:1 randomisation to 12-wk double-blind solifenacin or placebo treatment alongside urotherapy...
September 28, 2016: European Urology
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