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Nontuberculous mycobacteria

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https://www.readbyqxmd.com/read/29150178/-relationships-between-copd-and-nontuberculous-mycobacteria-pulmonary-infections
#1
REVIEW
C Balavoine, C Andréjak, S Marchand-Adam, F X Blanc
Nontuberculous mycobacteria (NTM) pulmonary infections are increasingly frequent in pneumological practice. The diagnosis is based on an association of clinical, microbiological and radiological criteria. Some risk factors for NTM disease have been described, including chronic respiratory diseases, but without specific focus on chronic obstructive pulmonary disease (COPD). COPD patients have more risk to be infected by NTM than patients with the main other chronic respiratory diseases (except cystic fibrosis) (odds ratio [OR] at 15...
November 14, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29126235/clinical-significance-of-interferon-%C3%AE-neutralizing-autoantibodies-against-disseminated-nontuberculous-mycobacterial-disease
#2
Ami Aoki, Takuro Sakagami, Kazutaka Yoshizawa, Kenjiro Shima, Mio Toyama, Yoshinari Tanabe, Hiroshi Moro, Nobumasa Aoki, Satoshi Watanabe, Toshiyuki Koya, Takashi Hasegawa, Kozo Morimoto, Atsuyuki Kurashima, Yoshihiko Hoshino, Bruce C Trapnell, Toshiaki Kikuchi
Background: Interferon-γ neutralizing autoantibodies (nIFNγ-autoAb) are reported in patients with disseminated nontuberculous mycobacteria (NTM) infection and may function by increasing the infection risk. Notwithstanding, the prevalence of nIFNγ-autoAb as well as the clinical presentation, diagnosis, and natural history, of disseminated NTM infection in these patients is poorly understood. Methods: In this retrospective observational study, data and sera for 331 Japanese subjects with mycobacterial infection were collected and analyzed...
November 8, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29111994/identification-of-the-infection-source-of-an-outbreak-of-mycobacterium-chelonae-keratitis-after-laser-in-situ-keratomileusis
#3
Heloisa Nascimento, Cristina Viana-Niero, Christiane Lourenço Nogueira, Paulo José Martins Bispo, Fernando Pinto, Camila de Paula Pereira Uzam, Cristianne Kayoko Matsumoto, Antônia Maria Oliveira Machado, Sylvia Cardoso Leão, Ana Luisa Höfling-Lima, Denise de Freitas
PURPOSE: Nontuberculous mycobacteria keratitis is a rare but challenging complication of laser in situ keratomileusis (LASIK). This study was conducted to determine the source(s) of infection in a cluster of cases of keratitis after LASIK and to describe this outbreak and patients' outcomes. METHODS: In this retrospective, case series, single-center study, 86 patients were included who underwent LASIK or photorefractive keratectomy between December 2011 and February 2012...
November 2, 2017: Cornea
https://www.readbyqxmd.com/read/29109010/a-novel-isothermal-amplification-based-method-to-detect-mycobacterium-tuberculosis-complex
#4
Dongxin Liu, Bing Zhao, Xichao Ou, Huiwen Zheng, Aijing Ma, Wencong He, Shengfen Wang, Yang Zhou, Hui Xia, Yang Zheng, Ping Hou, Guangxue He, Yanlin Zhao
Mycobacterium tuberculosis (MTB) is the causative agent of pulmonary tuberculosis. Rapid and accurate diagnosis is crucial to tuberculosis control and prevention. A series of diagnostic methods has been available for MTB detection; however, new rapid, simple and affordable methods are needed. In this study, a multiple cross displacement amplification (MCDA)-based assay was developed to detect the IS6110 gene of the M. tuberculosis complex. Hydroxy naphthol blue (HNB), a colorimetric indicator, was used to detect amplification products...
November 3, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29097168/synthesis-and-biological-evolution-of-hydrazones-derived-from-4-trifluoromethyl-benzohydrazide
#5
Martin Krátký, Szilvia Bősze, Zsuzsa Baranyai, Jiřina Stolaříková, Jarmila Vinšová
Reflecting the known biological activity of isoniazid-based hydrazones, seventeen hydrazones of 4-(trifluoromethyl)benzohydrazide as their bioisosters were synthesized from various benzaldehydes and aliphatic ketones. The compounds were screened for their in vitro activity against Mycobacterium tuberculosis, nontuberculous mycobacteria (M. avium, M. kansasii), bacterial and fungal strains. The most antimicrobial potent derivatives were also investigated for their cytostatic and cytotoxic properties against three cell lines...
October 21, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29072097/antimycobacterial-activity-of-nitrogen-heterocycles-derivatives-7-pyridine-4-yl-indolizine-derivatives-part-vii-8-12
#6
Anda-Mihaela Olaru, Violeta Vasilache, Ramona Danac, Ionel I Mangalagiu
A series of 13 compounds having a monoindolizine mono-salt skeleton was designed and synthesised in order to evaluate their antimycobacterial activity. The synthesis is efficient, involving only three steps: two alkylations and one 3 + 2 dipolar cycloaddition. The antimicrobial activity against Mycobacterium tuberculosis H37Rv grown under aerobic conditions was evaluated, eight compounds showing a very good antimycobacterial activity. SAR correlation reveals a certain influence of the R substituent from the para position of benzoyl moiety at position 3 of indolizine...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/29063147/importance-of-local-and-regional-scales-in-shaping-mycobacterial-abundance-in-freshwater-lakes
#7
Adélaïde Roguet, Claire Therial, Arnaud Catherine, Adèle Bressy, Gilles Varrault, Lila Bouhdamane, Viet Tran, Bruno J Lemaire, Brigitte Vincon-Leite, Mohamed Saad, Laurent Moulin, Françoise S Lucas
Biogeographical studies considering the entire bacterial community may underestimate mechanisms of bacterial assemblages at lower taxonomic levels. In this context, the study aimed to identify factors affecting the spatial and temporal dynamic of the Mycobacterium, a genus widespread in aquatic ecosystems. Nontuberculous mycobacteria (NTM) density variations were quantified in the water column of freshwater lakes at the regional scale (annual monitoring of 49 lakes in the Paris area) and at the local scale (2-year monthly monitoring in Créteil Lake) by real-time quantitative PCR targeting the atpE gene...
October 23, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/29059250/causative-species-of-nontuberculous-mycobacterial-lung-disease-and-comparative-investigation-on-clinical-features-of-mycobacterium-abscessus-complex-disease-a-retrospective-analysis-for-two-major-hospitals-in-a-subtropical-region-of-japan
#8
COMPARATIVE STUDY
Hiroaki Nagano, Takeshi Kinjo, Yuichiro Nei, Shin Yamashiro, Jiro Fujita, Tomoo Kishaba
Nontuberculous mycobacteria (NTM) lung disease is increasing globally. Although the etiological epidemiology of NTM is different across regions, Mycobacterium avium complex (MAC) is the leading cause of NTM lung disease in most countries, including mainland Japan. Okinawa is located in the southernmost region of Japan and is the only prefecture categorized as a subtropical region in Japan, it is therefore likely the etiological epidemiology of NTM lung disease is different from mainland Japan. From 2009 to 2015, the medical records of patients, with respiratory specimens positive for NTMs, visiting or admitted to two Okinawan hospitals, were retrospectively analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/29048292/pulmonary-versus-nonpulmonary-nontuberculous-mycobacteria-ontario-canada
#9
Sarah K Brode, Alex Marchand-Austin, Frances B Jamieson, Theodore K Marras
In Ontario, Canada, during 1998-2010, nontuberculous mycobacteria (NTM) from pulmonary sites comprised 96% of species/patient combinations isolated; annual rates of isolation and cases increased steadily. NTM isolates from nonpulmonary sites comprised 4% of species/patient combinations; annual rates and cases were temporally stable. NTM increases were driven exclusively by pulmonary isolates and disease.
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29048290/mycobacterium-shimoidei-a-rare-pulmonary-pathogen-queensland-australia
#10
Timothy M Baird, Robyn Carter, Geoffrey Eather, Rachel Thomson
Nontuberculous mycobacteria are human pathogens with increasing incidence and prevalence worldwide. Mycobacterium shimoidei is a rare cause of pulmonary disease, with only 15 cases previously reported. This series documents an additional 23 cases of M. shimoidei from Queensland, Australia, and highlights the pathogenicity and clinical role of this species.
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29040079/identification-of-nontuberculous-mycobacteria-isolated-from-hospital-water-by-sequence-analysis-of-the-hsp65-and-16s-rrna-genes
#11
Mehdi Roshdi Maleki, Hossein Samadi Kafil, Naser Harzandi, Seyyed Reza Moaddab
Nontuberculous mycobacteria (NTM) have emerged as an important cause of opportunistic nosocomial infections. NTM has frequently been isolated from hospital water distribution systems. The aim of this study was to survey the risk of NTM infections and determine the prevalence of NTM species in the hospital water distribution systems in Tabriz, Iran. One hundred and twenty samples of water from different sources of Tabriz hospitals were collected. The samples were filtered through 0.45-µm pore size membranes and decontaminated with 0...
October 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/29038903/-nontuberculous-mycobacteria-in-sputum-recommendations-for-diagnosis-and-treatment
#12
REVIEW
J Rademacher
Pulmonary diseases caused by nontuberculous mycobacteria (NTM) have increased over the last years and decades in Germany and also worldwide. Because the disease is more frequent in patients with immunodeficiencies and chronic respiratory diseases, e.g. bronchiectasis, advanced chronic obstructive lung disease (COPD) and cystic fibrosis (CF), an infection with mycobacteria should always be considered in this patient group. The detection in sputum alone is not an indication for treatment but the correct diagnosis should be based on the appropriate clinical symptoms as well as radiological and microbiological criteria...
November 2017: Der Internist
https://www.readbyqxmd.com/read/29017528/first-case-of-mycobacterium-marseillense-lymphadenitis-in-a-child
#13
A Azzali, C Montagnani, M T Simonetti, G Spinelli, M de Martino, L Galli
BACKGROUND: Nontuberculous mycobacteria (NTM) are pathogens that commonly affect the paediatric population and its most frequent manifestation is a cervicofacial lymphadenopathy. With the improvement of technologies, new species have been recently identified. CASE PRESENTATION: We report the first case of NMT lymphadenitis in a child caused by Mycobacterium marseillense, a newly described species belonging to Mycobacterium avium complex. CONCLUSIONS: Improving the identification of these newly discovered mycobacteria, further information will be available about their clinical involvement and their best treatment...
October 10, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29016684/performance-of-the-xpert-mtb-rif-assay-for-the-diagnosis-of-pulmonary-tuberculosis-and-rifampin-resistance-in-a-low-incidence-high-resource-setting
#14
Jason P Rice, Marva Seifert, Kathleen S Moser, Timothy C Rodwell
Performance of the Xpert MTB/RIF assay, designed to simultaneously detect Mycobacterium tuberculosis complex (MTBC) and rifampin (RIF) resistance, has been well documented in low-resource settings with high TB-incidence. However, few studies have assessed its accuracy in low TB incidence settings. We evaluated the performance of Xpert MTB/RIF using clinical sputum specimens routinely collected from suspect pulmonary TB patients over a 4-year time period in San Diego County, California. Xpert MTB/RIF results were compared to acid-fast bacilli (AFB) smear microscopy, mycobacterial culture, and phenotypic drug susceptibility testing (DST)...
2017: PloS One
https://www.readbyqxmd.com/read/28988958/mycobacterium-abscessus-and-massiliense-lung-infection-during-macrolide-treatment-for-bronchiolitis-obliterans-after-allogeneic-hematopoietic-stem-cell-transplantation
#15
Noriko Miyake, Yong Chong, Ruriko Nishida, Katsuto Takenaka, Koji Kato, Toshihiro Miyamoto, Akio Aono, Akiko Takaki, Satoshi Mitarai, Shinji Shimoda, Nobuyuki Shimono, Koichi Akashi
In patients undergoing allogeneic hematopoietic stem cell transplantation (allo-SCT), post-transplant lung infection is critical for their prognosis. Mycobacterium abscessus complex is not fully recognized as a nontuberculous mycobacteria (NTM) pathogen of post-SCT lung infection. Here, we present three post-allogeneic SCT patients who developed pulmonary infection caused by M. abscessus complex including M. abscessus and M. massiliense. In all three cases, macrolide antibiotics had been administered for bronchiolitis obliterans syndrome (BOS) before the confirmation of their infection, and macrolide resistance was noted in the M...
October 5, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28986190/incidence-and-risk-factors-for-nontuberculous-mycobacterial-infection-after-allogeneic-hematopoietic-cell-transplantation
#16
Jennifer Beswick, Elizabeth Shin, Fotios Michelis, Santhosh Thyagu, Auro Viswabandya, Jeffrey H Lipton, Hans Messner, Theodore K Marras, Dennis Dong Hwan Kim
Allogenic hematopoietic stem cell transplant (HCT) recipients are at risk of many infections. Nontuberculous mycobacteria (NTM) are increasingly recognized as clinically significant pathogens in this population. We investigated the incidence and risk factors for NTM infection after allogeneic HCT. This retrospective cohort study included all patients with allogeneic HCT at our institution during 2001 to 2013. Patients who developed significant NTM infection (NTM disease) were identified. Multivariable modeling was used to identify risk factors for NTM disease, and a risk score model was constructed to identify high-risk patients...
October 3, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28957340/body-habitus-in-patients-with-and-without-bronchiectasis-and-non-tuberculous-mycobacteria
#17
Michael D Schweitzer, Oriana Salamo, Michael Campos, Dean E Schraufnagel, Ruxana Sadikot, Mehdi Mirsaeidi
BACKGROUND: Female gender, tall stature, presence of bronchiectasis are associated with pulmonary nontuberculous mycobacterial (NTM) infections. The biologic relationship between the body habitus and NTM infection is not well defined and the body habitus profile of the patients with NTM and concurrent bronchiectasis is completely unknown. METHODS: We conducted a case control study at the Miami VA Healthcare System and the University of Illinois Medical Center on patients with pulmonary NTM infections between 2010 and 2015...
2017: PloS One
https://www.readbyqxmd.com/read/28953638/anti-interferon-%C3%AE-autoantibody-associated-disseminated-mycobacterium-abscessus-infection-mimicking-parotid-cancer-with-multiple-metastases-a-case-report
#18
Po-Hsiung Chang, Yu-Chung Chuang
RATIONALE: Among the nontuberculous mycobacteria, Mycobacterium abscessus is a common cause of skin, soft tissue, and bone infections. However, disseminated M. abscessus infection that mimics cancer metastasis with an underlying relatively immunocompetent condition has rarely been reported. PATIENT CONCERNS: A nonsmoking 73-year-old man with an underlying relatively immunocompetent condition reported a 2-month history of a mass in the region of his right parotid gland that had been steadily increasing in size...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28948162/beyond-pulmonary-nontuberculous-mycobacteria-disease-do-extra-pulmonary-forms-represent-an-emerging-clinical-and-public-health-threat
#19
Gabriele Biondi, Giovanni Sotgiu, Simone Dore, Paola Molicotti, Melania Ruggeri, Stefano Aliberti, Rosanna Satta
Pulmonary and extra-pulmonary diseases caused by nontuberculous mycobacteria: new clinical and public health threats http://ow.ly/87Dm30eMFd9.
July 2017: ERJ Open Research
https://www.readbyqxmd.com/read/28932687/multifocal-ulceronecrotic-skin-lesions-a-stigmatizing-case
#20
Fanny-Emmanuelle Bernier, Simon Grandjean Lapierre, Arwa El-Housseini, Mélissa Nantel-Battista, Sapha Barkati
Mycobacterium chelonae is a rapidly growing nontuberculous mycobacteria, ubiquitous in the environment and mostly involved in skin, soft tissue and bone infections. An atypical, severe and multifocal dermatological manifestation of Mycobacterium chelonae infection in an immunocompetent patient is described here. The lesions completely resolved using a multidisciplinary approach. This case emphasizes the important aspects of diagnosis, antimicrobial and surgical management.
2017: IDCases
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