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https://www.readbyqxmd.com/read/28210851/in-vivo-and-ex-vivo-sentinel-node-mapping-does-not-identify-the-same-lymph-nodes-in-colon-cancer
#1
Helene Schou Andersen, Astrid Louise Bjørn Bennedsen, Stefan Kobbelgaard Burgdorf, Jens Ravn Eriksen, Susanne Eiholm, Anders Toxværd, Lene Buhl Riis, Jacob Rosenberg, Ismail Gögenur
INTRODUCTION: Identification of lymph nodes and pathological analysis is crucial for the correct staging of colon cancer. Lymph nodes that drain directly from the tumor area are called "sentinel nodes" and are believed to be the first place for metastasis. The purpose of this study was to perform sentinel node mapping in vivo with indocyanine green and ex vivo with methylene blue in order to evaluate if the sentinel lymph nodes can be identified by both techniques. METHODS: Patients with colon cancer UICC stage I-III were included from two institutions in Denmark from February 2015 to January 2016...
February 16, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28209703/determining-rates-of-overweight-and-obese-status-in-children-using-electronic-medical-records-cross-sectional-study
#2
Catherine S Birken, Karen Tu, William Oud, Sarah Carsley, Miranda Hanna, Gerald Lebovic, Astrid Guttmann
OBJECTIVE: To determine the prevalence of overweight and obese status in children by age, sex, and visit type, using data from EMRALD(®) (Electronic Medical Record Administrative data Linked Database). DESIGN: Heights and weights were abstracted for children 0 to 19 years of age who had at least one well-child visit from January 2010 to December 2011. Using the most recent visit, the proportions and 95% CIs of patients defined as overweight and obese were compared by age group, sex, and visit type using the World Health Organization growth reference standards...
February 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28209606/long-term-experiences-of-norwegian-live-kidney-donors-qualitative-in-depth-interviews
#3
Käthe B Meyer, Ida Torunn Bjørk, Astrid Klopstad Wahl, Annette Lennerling, Marit Helen Andersen
OBJECTIVE: Live kidney donation is generally viewed as a welcome treatment option for severe kidney disease. However, there is a disparity in the body of research on donor experiences and postdonation outcome, and lack of knowledge on long-term consequences described by the donors. This study was conducted to provide insight into donors' subjective meanings and interpretation of their experiences ∼10 years after donation. DESIGN: Qualitative explorative in-depth interviews...
February 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28208246/combined-proteome-and-eicosanoid-profiling-approach-for-revealing-implications-of-human-fibroblasts-in-chronic-inflammation
#4
Ammar Tahir, Andrea Bileck, Besnik Muqaku, Laura Niederstaetter, Dominique Kreutz, Rupert L Mayer, Denise Wolrab, Samuel M Meier, Astrid Slany, Christopher Gerner
During inflammation, proteins and lipids act in a concerted fashion, calling for combined analyses. Fibroblasts are powerful mediators of chronic inflammation. However, little is known about eicosanoid formation by human fibroblasts. The aim of this study was to analyze the formation of the most relevant inflammation mediators including proteins and lipids in human fibroblasts upon inflammatory stimulation and subsequent treatment with dexamethasone, a powerful antiphlogistic drug. Label-free quantification was applied for proteome profiling, while an in-house established data-dependent analysis method based on high-resolution mass spectrometry was applied for eicosadomics...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28207633/acute-liver-failure-injury-related-to-drug-reaction-with-eosinophilia-and-systemic-symptoms-outcomes-and-prognostic-factors
#5
Philippe Ichai, Astrid Laurent-Bellue, Faouzi Saliba, David Moreau, Camille Besch, Claire Francoz, Laurence Valeyrie-Allanore, Sylvie Roussin Bretagne, Marc Boudon, Teresa Maria Antonini, Florent Artru, Gabriella Pittau, Olivier Roux, Daniel Azoulay, Eric Levesque, François Durand, Catherine Guettier, Didier Samuel
BACKGROUND: Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) is a rare severe adverse drug induced reaction with multiorgan involvement. The outcome and prediction of those patients who develop severe acute liver injury (sALI) or acute liver failure (ALF) remain little known. METHODS: A multicenter retrospective study of patients admitted with a diagnosis of DRESS-related sALI or ALF. Histological review was performed on liver core biopsies from native livers...
February 15, 2017: Transplantation
https://www.readbyqxmd.com/read/28196525/drug-based-pain-management-for-people-with-dementia-after-hip-or-pelvic-fractures-a-systematic-review
#6
Kai Moschinski, Silke Kuske, Silke Andrich, Astrid Stephan, Irmela Gnass, Erika Sirsch, Andrea Icks
BACKGROUND: Studies indicate that people with dementia do not receive the same amount of analgesia after a hip or pelvic fracture compared to those without cognitive impairment. However, there is no systematic review that shows to what extent drug-based pain management is performed for people with dementia following a hip or pelvic fracture. The aim of this systematic review was to identify and analyse studies that investigate drug-based pain management for people with dementia with a hip or pelvic fracture in all settings...
February 14, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28188211/cluh-regulates-mitochondrial-metabolism-by-controlling-translation-and-decay-of-target-mrnas
#7
Désirée Schatton, David Pla-Martin, Marie-Charlotte Marx, Henriette Hansen, Arnaud Mourier, Ivan Nemazanyy, Alberto Pessia, Peter Zentis, Teresa Corona, Vangelis Kondylis, Esther Barth, Astrid C Schauss, Vidya Velagapudi, Elena I Rugarli
Mitochondria are essential organelles that host crucial metabolic pathways and produce adenosine triphosphate. The mitochondrial proteome is heterogeneous among tissues and can dynamically change in response to different metabolic conditions. Although the transcriptional programs that govern mitochondrial biogenesis and respiratory function are well known, posttranscriptional regulatory mechanisms remain unclear. In this study, we show that the cytosolic RNA-binding protein clustered mitochondria homologue (CLUH) regulates the expression of a mitochondrial protein network supporting key metabolic programs required under nutrient deprivation...
February 10, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28184970/differences-in-the-frequencies-of-hla-class-i-and-ii-alleles-between-german-patients-with-renal-cell-carcinoma-and-healthy-controls
#8
Steffen Goebel, Astrid Kehlen, Karen Bluemke, Wolfgang Altermann, Gerald Schlaf, Kersten Fischer, Paolo Fornara, Bernd Wullich, Sven Wach, Helge Taubert
The human leukocyte antigen (HLA) system is a major part of the human immune system and has an impact on tumor initiation, tumor progression, and immunosurveillance. Renal cell carcinoma tumors are considered to be immunogenic. Therefore, we studied the allele frequencies of four gene loci (HLA-A, -B, -C, and HLA-DR) in a cohort of German renal cell carcinoma (RCC) patients and in healthy controls. HLA-A-C were determined using serological methods, whereas HLA-C12, C14, C16, C18, and HLA-DR were characterized through the use of standard molecular biological methods...
February 9, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28183531/cardiomyocyte-hypertrophy-in-arrhythmogenic-cardiomyopathy
#9
Mustafa Gerçek, Muhammed Gerçek, Sebastian Kant, Sakine Simsekyilmaz, Astrid Kassner, Hendrik Milting, Elisa A Liehn, Rudolf E Leube, Claudia A Krusche
Arrhythmogenic cardiomyopathy (AC) is a hereditary disease leading to sudden cardiac death or heart failure. AC pathology is characterized by cardiomyocyte loss and replacement fibrosis. Our goal was to determine whether cardiomyocytes respond to AC progression by pathological hypertrophy. To this end, we examined tissue samples from AC patients with end-stage heart failure and tissue samples that were collected at different disease stages from desmoglein 2-mutant mice, a well characterized AC model. We find that cardiomyocyte diameters are significantly increased in right ventricles of AC patients...
February 6, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28183396/denheart-differences-in-physical-and-mental-health-across-cardiac-diagnoses-at-hospital-discharge
#10
Selina Kikkenborg Berg, Trine Bernholdt Rasmussen, Lars Thrysoee, Astrid Lauberg, Britt Borregaard, Anne Vinggaard Christensen, Ola Ekholm, Knud Juel, Jette Rolf Svanholm
OBJECTIVE: To describe: (i) differences in patient reported physical and mental health outcomes at hospital discharge between a) cardiac diagnostic groups and b) cardiac patients and a national representative reference population and to describe (ii) in-hospital predicting factors for patient reported outcomes. METHODS: A national cross-sectional survey combined with national register data. From April 2013 to April 2014 all patients (n=34,564) discharged or transferred from one of five Danish Heart Centres were invited to participate...
March 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28183321/biomarker-analysis-of-the-neosphere-study-pertuzumab-trastuzumab-and-docetaxel-versus-trastuzumab-plus-docetaxel-pertuzumab-plus-trastuzumab-or-pertuzumab-plus-docetaxel-for-the-neoadjuvant-treatment-of-her2-positive-breast-cancer
#11
Giampaolo Bianchini, Astrid Kiermaier, Giulia Valeria Bianchi, Young-Hyuck Im, Tadeusz Pienkowski, Mei-Ching Liu, Ling-Ming Tseng, Mitch Dowsett, Lila Zabaglo, Sarah Kirk, Tania Szado, Jennifer Eng-Wong, Lukas C Amler, Pinuccia Valagussa, Luca Gianni
BACKGROUND: NeoSphere showed significantly higher pathologic complete response (pCR) with neoadjuvant pertuzumab, trastuzumab, and docetaxel compared with trastuzumab plus docetaxel, pertuzumab plus trastuzumab, or pertuzumab plus docetaxel. We assessed associations between human epidermal growth factor receptor 2 (HER2) pathway-related biomarkers and clinical outcome in response to these regimens. METHODS: Tumor, serum, and whole blood samples were collected at baseline and post neoadjuvant treatment before surgery...
February 9, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28182282/antenatal-determinants-of-parental-attachment-and-parenting-alliance-how-do-mothers-and-fathers-differ
#12
Rita Luz, Astrid George, Rachel Vieux, Elisabeth Spitz
Parental (parent-to-infant) attachment and parenting alliance are defined as two important components of psychoaffective adjustment to the parental role. This study aimed to build a predictive model of parental attachment and parenting alliance for mothers and fathers using partial least squares-structural equation modeling. Specifically, we were interested in assessing how adult romantic attachment, marital quality, and psychological distress influenced parental attachment (parent-to-infant) and parenting alliance...
February 9, 2017: Infant Mental Health Journal
https://www.readbyqxmd.com/read/28181256/psychological-processes-in-young-bullies-versus-bully-victims
#13
Anouk van Dijk, Astrid M G Poorthuis, Tina Malti
Some children who bully others are also victimized themselves ("bully-victims") whereas others are not victimized themselves ("bullies"). These subgroups have been shown to differ in their social functioning as early as in kindergarten. What is less clear are the motives that underlie the bullying behavior of young bullies and bully-victims. The present study examined whether bullies have proactive motives for aggression and anticipate to feel happy after victimizing others, whereas bully-victims have reactive motives for aggression, poor theory of mind skills, and attribute hostile intent to others...
February 8, 2017: Aggressive Behavior
https://www.readbyqxmd.com/read/28179964/prognostic-impact-of-the-tumor-marker-ca-15-3-in-patients-with-breast-cancer-and-bone-metastases-treated-with-palliative-radiotherapy
#14
Carsten Nieder, Astrid Dalhaug, Ellinor Haukland, Bard Mannsaker, Adam Pawinski
BACKGROUND: The aim of the study was to explore the prognostic impact of different abnormal blood tests and the tumor marker CA 15-3 as well as established parameters such as disease extent and receptor status in patients with bone metastases from breast cancer who received palliative radiotherapy in addition to contemporary systemic treatment. METHODS: This was a retrospective uni- and multivariate analysis of 118 female patients treated in the time period from 2007 to 2014 (median follow-up 28 months)...
March 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28179345/correlation-of-tumor-and-peritumoral-edema-volumes-with-survival-in-patients-with-cerebral-metastases
#15
Johannes Kerschbaumer, Marlies Bauer, Marina Popovscaia, Astrid E Grams, Claudius Thomé, Christian F Freyschlag
BACKGROUND: Surgical resection in combination with radiotherapy in selected cases remains the best option for patients with cerebral metastases. Postoperative relapse of brain metastases occurs frequently and can be reduced by postoperative whole-brain radiotherapy (WBRT). Continuous spread of tumor cells from the primary lesions is debated as a cause of recurrence. It is well known that in gliomas, infiltration takes place within the surrounding edema. Obviously, most brain metastases are usually associated with peritumoral edema, which may act as an indicator of infiltration and more aggressive tumor biology...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28178682/comprehensive-analysis-of-pd-l1-expression-in-glioblastoma-multiforme
#16
Dieter Henrik Heiland, Gerrit Haaker, Daniel Delev, Bianca Mercas, Waseem Masalha, Sabrina Heynckes, Annette Gäbelein, Dietmar Pfeifer, Maria Stella Carro, Astrid Weyerbrock, Marco Prinz, Oliver Schnell
Glioblastoma multiforme are highly malignant brain tumours with frequent genetic and epigenetic alterations. The poor clinical outcome of these tumours necessitates the development of new treatment options. Immunotherapies for glioblastoma multiforme including PD1/PD-L1 inhibition are currently tested in ongoing clinical trials. The purpose of this study was to investigate the molecular background of PD-L1 expression in glioblastoma multiforme and to find associated pathway activation and genetic alterations...
February 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28178071/recommendations-for-a-first-core-outcome-measurement-set-for-complex-regional-pain-syndrome-clinical-studies-compact
#17
Grieve Sharon, Perez Roberto Sgm, Birklein Frank, Brunner Florian, Bruehl Stephen, Harden R Norman, Packham Tara, Gobeil Francois, Haigh Richard, Holly Janet, Terkelsen Astrid, Davies Lindsay, Lewis Jennifer, Thomassen Ilona, Connett Robyn, Worth Tina, Vatine Jean-Jacques, McCabe Candida S
Complex Regional Pain Syndrome (CRPS) is a persistent pain condition that remains incompletely understood and challenging to treat. Historically, a wide range of different outcome measures have been used to capture the multidimensional nature of CRPS. This has been a significant limiting factor in the advancement of our understanding of the mechanisms and management of CRPS.In 2013, an international consortium of patients, clinicians, researchers and industry representatives was established, to develop and agree on a minimum core set of standardised outcome measures for use in future CRPS clinical research, including but not limited to clinical trials within adult populationsThe development of a core measurement set was informed through workshops and supplementary work, using an iterative consensus process...
February 4, 2017: Pain
https://www.readbyqxmd.com/read/28177407/transformation-of-sulfonamides-and-tetracyclines-during-anaerobic-fermentation-of-liquid-manure
#18
Astrid Spielmeyer, Franziska Stahl, Madeleine S Petri, Walter Zerr, Hubertus Brunn, Gerd Hamscher
Liquid manure is frequently used as soil fertilizer due to its high nutrient content. It can also contain residues of pharmaceuticals, such as antibiotics, if farm animals are medicated. The anaerobic fermentation process in biogas plants is discussed as one way to reduce the input of antibiotics into the environment. Therefore, 10 worldwide-applied sulfonamides (sulfachloropyridazine, sulfadiazine, sulfadimethoxine, sulfaguanidine, sulfamerazine, sulfamethazine, sulfamethoxazole, sulfamethoxypyridazine, sulfapyridine, and sulfathiazole) and four frequently used tetracyclines (chlortetracycline, doxycycline, oxytetracycline, and tetracycline) were investigated concerning their elimination pattern during anaerobic fermentation...
January 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28177136/degeneracy-rules
#19
Astrid A Prinz
No abstract text is available yet for this article.
February 8, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28177065/gait-speed-and-grip-strength-reflect-cognitive-impairment-and-are-modestly-related-to-incident-cognitive-decline-in-memory-clinic-patients-with-subjective-cognitive-decline-and-mild-cognitive-impairment-findings-from-the-4c-study
#20
Astrid M Hooghiemstra, Inez H G B Ramakers, Nicole Sistermans, Yolande A L Pijnenburg, Pauline Aalten, Renske E G Hamel, René J F Melis, Frans R J Verhey, Marcel G M Olde Rikkert, Philip Scheltens, Wiesje M van der Flier
No abstract text is available yet for this article.
February 8, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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