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https://www.readbyqxmd.com/read/29772844/leucine-supplementation-does-not-attenuate-skeletal-muscle-loss-during-leg-immobilization-in-healthy-young-men
#1
Evelien M P Backx, Astrid M H Horstman, Gabriel N Marzuca-Nassr, Janneau van Kranenburg, Joey S Smeets, Cas J Fuchs, Anniek A W Janssen, Lisette C P G M de Groot, Tim Snijders, Lex B Verdijk, Luc J C van Loon
BACKGROUND: Short successive periods of physical inactivity occur throughout life and contribute considerably to the age-related loss of skeletal muscle mass. The maintenance of muscle mass during brief periods of disuse is required to prevent functional decline and maintain metabolic health. OBJECTIVE: To assess whether daily leucine supplementation during a short period of disuse can attenuate subsequent muscle loss in vivo in humans. METHODS: Thirty healthy (22 ± 1 y) young males were exposed to a 7-day unilateral knee immobilization intervention by means of a full leg cast with (LEU, n = 15) or without (CON, n = 15) daily leucine supplementation (2...
May 17, 2018: Nutrients
https://www.readbyqxmd.com/read/29771135/electromembrane-extraction-of-substances-with-weakly-basic-properties-a-fundamental-study-with-benzodiazepines
#2
Linda Vårdal, Elisabeth L Øiestad, Astrid Gjelstad, Stig Pedersen-Bjergaard
AIM: Electromembrane extraction (EME) of weakly basic benzodiazepines was investigated (-1.47 < pKa < 5.01). MATERIALS & METHODS: 96-well EME was performed with strongly acidic conditions in the acceptor solution using 250-mM trifluoroacetic acid to maximize ionization. RESULTS & CONCLUSION: Recoveries more than 80% were obtained for analytes with pKa > 2, whereas EME was less efficient for substances with pKa < 2...
May 17, 2018: Bioanalysis
https://www.readbyqxmd.com/read/29769702/fine-mapping-of-98-obesity-loci-in-mexican-children
#3
Hsin Yen Liu, Akram Alyass, Arkan Abadi, Jesus Peralta-Romero, Fernando Suarez, Jaime Gomez-Zamudio, Astride Audirac, Esteban J Parra, Miguel Cruz, David Meyre
BACKGROUND/OBJECTIVES: Mexico has one of the highest prevalence of childhood obesity in the world. Genome-wide association studies (GWAS) for obesity have identified multiple single-nucleotide polymorphisms (SNPs) in populations of European, East Asian, and African descent. The contribution of these loci to obesity in Mexican children is unclear. We assessed the transferability of 98 obesity loci in Mexican children and fine-mapped the association signals. SUBJECTS/METHODS: The study included 405 and 390 Mexican children with normal weight and obesity...
March 12, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29768723/importance-of-choice-of-materials-and-methods-in-pd-l1-and-til-assessment-in-oropharyngeal-squamous-cell-carcinoma
#4
Astrid De Meulenaere, Tijl Vermassen, David Creytens, Sandrine Aspeslagh, Philippe Deron, Frederic Duprez, Sylvie Rottey, Jo Van Dorpe, Liesbeth Ferdinande
INTRODUCTION: A great deal of research is being conducted into PD-L1 immunohistochemistry (IHC) and tumor infiltrating lymphocytes (TILs) as predictive or prognostic biomarkers for immunotherapy, although several practical issues exist concerning their assessment. The aim of this research was therefore to assess the importance of choice of materials and methods in PD-L1 and TILs scoring in oropharyngeal squamous cell carcinoma (OSCC). METHODS AND RESULTS: IHC for PD-L1 (SP142 and 22C3 clone) and TILs subtyping was performed on formalin-fixed paraffin-embedded tissue slides (biopsy, resection and/or lymph nodes specimens) of 99 patients with OSCC...
May 16, 2018: Histopathology
https://www.readbyqxmd.com/read/29768676/ccl19-with-ccl21-tail-displays-enhanced-glycosaminoglycan-binding-with-retained-chemotactic-potency-in-dendritic-cells
#5
Astrid S Jørgensen, Pontian E Adogamhe, Julia M Laufer, Daniel F Legler, Christopher T Veldkamp, Mette M Rosenkilde, Gertrud M Hjortø
CCL19 is more potent than CCL21 in inducing chemotaxis of human dendritic cells (DC). This difference is attributed to 1) a stronger interaction of the basic C-terminal tail of CCL21 with acidic glycosaminoglycans (GAGs) in the environment and 2) an autoinhibitory function of this C-terminal tail. Moreover, different receptor docking modes and tissue expression patterns of CCL19 and CCL21 contribute to fine-tuned control of CCR7 signaling. Here, we investigate the effect of the tail of CCL21 on chemokine binding to GAGs and on CCR7 activation...
May 16, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29768265/disease-burden-psychological-well-being-and-attitudes-regarding-the-set-of-emergency-medication-in-adults-with-insect-venom-allergy
#6
Marthe-Lisa Schaarschmidt, Mandy Gutknecht, Lisa Schoeben, Astrid Schmieder
BACKGROUND: Insect venom allergy is common and greatly impairs patients' quality of life. Additionally, low compliance with carrying emergency medication is reported. The aim of our study was to analyze the disease burden, levels of anxiety and depression, and to evaluate attitudes towards the set of emergency medication in affected patients. METHODS: Between April 2016 and January 2017, patients ≥18 years visiting our department because of an insect venom allergy were asked to complete a paper-based questionnaire...
May 16, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29765702/is-radiographic-progression-in-radiographic-axial-spondyloarthritis-related-to-matrix-metalloproteinase-degradation-of-extracellular-matrix
#7
Anne Sofie Siebuhr, Desirée van der Heijde, Anne-C Bay-Jensen, Morten Asser Karsdal, Robert Landewé, Astrid van Tubergen, Sofia Ramiro
Background: Radiographic axial spondyloarthritis (r-axSpA) is associated with extracellular matrix (ECM) remodelling of affected tissues. We investigated whether there was a relationship between biomarkers of ECM remodelling and 2-year radiographic progression in r-axSpA. Methods: Patients from the Outcome in Ankylosing Spondylitis International Study (OASIS) were included if they had serum, clinical and spinal radiographic assessments available at baseline and 2 years later...
2018: RMD Open
https://www.readbyqxmd.com/read/29764836/subcellular-localization-of-antigen-dictates-delivery-of-cd4-t-cell-help-for-the-ctl-response-upon-therapeutic-dna-vaccination-into-the-skin
#8
Nikolina Bąbała, Astrid Bovens, Evert de Vries, Victoria Iglesias-Guimarais, Tomasz Ahrends, Matthew F Krummel, Jannie Borst, Adriaan D Bins
In a mouse model of therapeutic DNA vaccination, we studied how the subcellular localization of vaccine protein impacts antigen delivery to professional antigen presenting cells (pAPCs) and efficiency of CTL priming. Cytosolic, membrane-bound, nuclear, and secretory versions of ZsGreen fluorescent protein, conjugated to MHC class I and -II ovalbumin (OVA) epitopes were expressed in keratinocytes by DNA vaccination into the skin. ZsGreen-OVA versions reached B cells in the skin-draining lymph node (dLN) that proved irrelevant for CTL priming...
May 15, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29763583/m%C3%A3-ller-glial-cells-contribute-to-dim-light-vision-in-the-spectacled-caiman-caiman-crocodilus-fuscus-analysis-of-retinal-light-transmission
#9
Silke Agte, Alexey Savvinov, Anett Karl, Astrid Zayas-Santiago, Elke Ulbricht, Vladimir I Makarov, Andreas Reichenbach, Andreas Bringmann, Serguei N Skatchkov
In this study, we show the capability of Müller glial cells to transport light through the inverted retina of reptiles, specifically the retina of the spectacled caimans. Thus, confirming that Müller cells of lower vertebrates also improve retinal light transmission. Confocal imaging of freshly isolated retinal wholemounts, that preserved the refractive index landscape of the tissue, indicated that the retina of the spectacled caiman is adapted for vision under dim light conditions. For light transmission experiments, we used a setup with two axially aligned objectives imaging the retina from both sides to project the light onto the inner (vitreal) surface and to detect the transmitted light behind the retina at the receptor layer...
May 12, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29761123/zika-virus-and-guillain-barr%C3%A3-syndrome-in-bangladesh
#10
Corine H GeurtsvanKessel, Zhahirul Islam, Md Badrul Islam, Sandra Kamga, Nowshin Papri, David A M C van de Vijver, Chantal Reusken, Ramona Mogling, Astrid P Heikema, Israt Jahan, Florence K Pradel, Rebecca L Pavlicek, Quazi D Mohammad, Marion P G Koopmans, Bart C Jacobs, Hubert P Endtz
Objective: Previous studies have associated Guillain-Barré syndrome (GBS) with Zika virus (ZIKV) outbreaks in South America and Oceania. In Asia, ZIKV is known to circulate widely, but the association with Guillain-Barré syndrome is unclear. We investigated whether endemic ZIKV infection is associated with the development of GBS. Methods: A prospective study was conducted from 2011 to 2015 in Bangladesh. A total of 418 patients and 418 healthy family controls were included in the study...
May 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29761035/small-tropical-islands-with-dense-human-population-differences-in-water-quality-of-near-shore-waters-are-associated-with-distinct-bacterial-communities
#11
Hauke F Kegler, Christiane Hassenrück, Pia Kegler, Tim C Jennerjahn, Muhammad Lukman, Jamaluddin Jompa, Astrid Gärdes
Water quality deterioration caused by an enrichment in inorganic and organic matter due to anthropogenic inputs is one of the major local threats to coral reefs in Indonesia. However, even though bacteria are important mediators in coral reef ecosystems, little is known about the response of individual taxa and whole bacterial communities to these anthropogenic inputs. The present study is the first to investigate how bacterial community composition responds to small-scale changes in water quality in several coral reef habitats of the Spermonde Archipelago including the water column, particles, and back-reef sediments, on a densely populated and an uninhabited island...
2018: PeerJ
https://www.readbyqxmd.com/read/29760384/instability-of-the-northeast-greenland-ice-stream-over-the-last-45-000-years
#12
Nicolaj K Larsen, Laura B Levy, Anders E Carlson, Christo Buizert, Jesper Olsen, Astrid Strunk, Anders A Bjørk, Daniel S Skov
The sensitivity of the Northeast Greenland Ice Stream (NEGIS) to prolonged warm periods is largely unknown and geological records documenting such long-term changes are needed to place current observations in perspective. Here we use cosmogenic surface exposure and radiocarbon ages to determine the magnitude of NEGIS margin fluctuations over the last 45 kyr (thousand years). We find that the NEGIS experienced slow early Holocene ice-margin retreat of 30-40 m a-1 , likely as a result of the buttressing effect of sea-ice or shelf-ice...
May 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29759103/dietary-taste-patterns-by-sex-and-weight-status-in-the-netherlands
#13
Astrid W B van Langeveld, Pey Sze Teo, Jeanne H M de Vries, Edith J M Feskens, Cees de Graaf, Monica Mars
Taste is a key driver of food choice and intake. Taste preferences are widely studied, unlike the diet's taste profile. This study assessed dietary taste patterns in the Netherlands by sex, BMI, age and education. A taste database, containing 476 foods' taste values, was combined with 2-d 24-h recalls in two study populations. The percentage of energy intake from six taste clusters was assessed in the Dutch National Food Consumption Survey (DNFCS 2007-2010; n 1351) and in an independent observational study: the Nutrition Questionnaires plus (NQplus) study (2011-2013; n 944)...
May 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29756358/echocardiographic-parameters-to-identify-sickle-cell-patients-with-cardio-pathology
#14
Simbo Chiadika, Mary Lim-Fung, Fiorella Llanos-Chea, Astrid Serauto Canache, Wei Yang, Christina Paruthi, Xu Zhang, David D McPherson, Modupe Idowu
BACKGROUND: Sickle cell disease (SCD) affects millions of people and causes chronic hemolytic anemia leading to vasculopathies such as pulmonary hypertension and abnormalities in cardiac function that increase complications and mortality. It is therefore crucial to identify cardiac abnormalities in SCD. We aimed to assess the prevalence of echocardiographic parameters in SCD to help identify cardiopulmonary risk. METHODS: Ninety-one patients (53% male), median age of 30, body surface area (BSA) of 1...
May 14, 2018: Echocardiography
https://www.readbyqxmd.com/read/29754815/an-acquired-vulnerability-of-drug-resistant-melanoma-with-therapeutic-potential
#15
Liqin Wang, Rodrigo Leite de Oliveira, Sanne Huijberts, Evert Bosdriesz, Nora Pencheva, Diede Brunen, Astrid Bosma, Ji-Ying Song, John Zevenhoven, G Tjitske Los-de Vries, Hugo Horlings, Bastiaan Nuijen, Jos H Beijnen, Jan H M Schellens, Rene Bernards
BRAF(V600E) mutant melanomas treated with inhibitors of the BRAF and MEK kinases almost invariably develop resistance that is frequently caused by reactivation of the mitogen activated protein kinase (MAPK) pathway. To identify novel treatment options for such patients, we searched for acquired vulnerabilities of MAPK inhibitor-resistant melanomas. We find that resistance to BRAF+MEK inhibitors is associated with increased levels of reactive oxygen species (ROS). Subsequent treatment with the histone deacetylase inhibitor vorinostat suppresses SLC7A11, leading to a lethal increase in the already-elevated levels of ROS in drug-resistant cells...
April 28, 2018: Cell
https://www.readbyqxmd.com/read/29754398/development-and-course-of-chronic-pain-over-four-years-in-the-general-population-the-hunt-pain-study
#16
Tormod Landmark, Ola Dale, Pål Romundstad, Astrid Woodhouse, Stein Kaasa, Petter C Borchgrevink
BACKGROUND: Epidemiological studies of chronic pain frequently report high prevalence estimates. However, there is little information about the development and natural course of chronic pain. METHODS: We followed a random sample of participants from a population-based study (HUNT 3) with annual measures over four years. RESULTS: Among those without chronic pain at baseline, the probability of developing moderate to severe chronic pain (cumulative incidence) during the first year was 5%, a pain status that was maintained among 38% at the second follow-up...
May 13, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29753728/retinal-adaptation-to-dim-light-vision-in-spectacled-caimans-caiman-crocodilus-fuscus-analysis-of-retinal-ultrastructure
#17
Anett Karl, Silke Agte, Astrid Zayas-Santiago, Felix N Makarov, Yomarie Rivera, Jan Benedikt, Mike Francke, Andreas Reichenbach, Serguei N Skatchkov, Andreas Bringmann
It has been shown that mammalian retinal glial (Müller) cells act as living optical fibers that guide the light through the retinal tissue to the photoreceptor cells (Agte et al., 2011; Franze et al., 2007). However, for nonmammalian species it is unclear whether Müller cells also improve the transretinal light transmission. Furthermore, for nonmammalian species there is a lack of ultrastructural data of the retinal cells, which, in general, delivers fundamental information of the retinal function, i.e. the vision of the species...
May 10, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29752891/effectiveness-and-tolerability-of-direct-acting-antivirals-for-chronic-hepatitis-c-patients-in-a-southern-state-of-brazil
#18
Vinicius Lins Ferreira, Helena Hiemisch Lobo Borba, Astrid Wiens, Maria Lucia Alves Pedroso, Vanessa Ferreira de Camargo Radunz, Cláudia Alexandra Pontes Ivantes, Aline Satie Oba Kuniyoshi, Roberto Pontarolo
BACKGROUND: This study aimed to evaluate the clinical effectiveness in terms of sustained virological response (SVR) and tolerability of available second generation direct-acting antivirals (DAAs) in Brazilian patients. METHODS: This was a retrospective observational study conducted in six centers in Southern Brazil. The sample comprised adult patients who were chronically infected with hepatitis C virus (HCV), regardless of virus genotype, fibrosis stage, or prior treatment...
May 9, 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29751106/curcumin-exerts-its-antitumor-effects-in-a-context-dependent-fashion
#19
Dominique Kreutz, Chomdao Sinthuvanich, Andrea Bileck, Lukas Janker, Besnik Muqaku, Astrid Slany, Christopher Gerner
Proteome profiling profoundly contributes to the understanding of cell response mechanisms to drug actions. Such knowledge may become a key to improve personalized medicine. In the present study, the effects of the natural remedy curcumin on breast cancer model systems were investigated. MCF-7, ZR-75-1 and TGF-β1 pretreated fibroblasts, mimicking cancer-associated fibroblasts (CAFs), were treated independently as well as in tumor cell/CAF co-cultures. Remarkably, co-culturing with CAF-like cells (CLCs) induced different proteome alterations in MCF-7 and ZR-75-1 cells, respectively...
May 8, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29750268/inferring-and-modeling-inheritance-of-differentially-methylated-changes-across-multiple-generations
#20
Pascal Belleau, Astrid Deschênes, Marie-Pier Scott-Boyer, Mathieu Dalvai, Janice Bailey, Arnaud Droit
High-throughput methylation sequencing enables genome-wide detection of differentially methylated sites (DMS) or regions (DMR). Increasing evidence suggests that treatment-induced DMS can be transmitted across generations, but the analysis of induced methylation changes across multiple generations is complicated by the lack of sound statistical methods to evaluate significance levels. Due to software design, DMS detection was usually made on each generation separately, thus disregarding stochastic effects expected when a large number of DMS is detected in each generation...
May 10, 2018: Nucleic Acids Research
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