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https://www.readbyqxmd.com/read/28616185/asymmetry-matters-a-genomic-assessment-of-directional-biases-in-gene-flow-between-hybridizing-spruces
#1
Guillaume de Lafontaine, Jean Bousquet
Assessing directional bias in interspecific gene flow might be important in determining the evolutionary trajectory of closely related species pairs. Using a set of 300 single nucleotide polymorphisms (SNPs) having variable propensity to cross species boundary, we evaluated the genomic extent and direction of interspecific gene flow in a progenitor-derivative spruce species pair (black spruce and red spruce). A higher rate of gene flow was found from black spruce toward red spruce purebreds than vice versa...
June 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28570635/probing-planetary-biodiversity-with-dna-barcodes-the-noctuoidea-of-north-america
#2
Reza Zahiri, J Donald Lafontaine, B Christian Schmidt, Jeremy R deWaard, Evgeny V Zakharov, Paul D N Hebert
This study reports the assembly of a DNA barcode reference library for species in the lepidopteran superfamily Noctuoidea from Canada and the USA. Based on the analysis of 69,378 specimens, the library provides coverage for 97.3% of the noctuoid fauna (3565 of 3664 species). In addition to verifying the strong performance of DNA barcodes in the discrimination of these species, the results indicate close congruence between the number of species analyzed (3565) and the number of sequence clusters (3816) recognized by the Barcode Index Number (BIN) system...
2017: PloS One
https://www.readbyqxmd.com/read/28556672/faster-use-and-fewer-failures-with-needle-free-nasal-glucagon-versus-injectable-glucagon-in-severe-hypoglycemia-rescue-a-simulation-study
#3
Jean-François Yale, Hélène Dulude, Marc Egeth, Claude A Piché, Martin Lafontaine, Dolorès Carballo, Rebecca Margolies, Emily Dissinger, Adam R Shames, Nicole Kaplowitz, Michelle Xiaotian Zhang, Shuyu Zhang, Cristina B Guzman
BACKGROUND: During severe hypoglycemic episodes, people with diabetes depend on others to help with treatment. We compared needle-free nasal glucagon and commercially available injectable glucagon for ease of use by caregivers of people with diabetes and by others in treating simulated episodes of severe hypoglycemia. METHODS: Sixteen instructed caregivers and 15 noninstructed acquaintances administered nasal and injectable glucagon to manikins, simulating unconscious people with diabetes during severe hypoglycemia episodes...
May 30, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28542199/specialized-box-c-d-snornps-act-as-antisense-guides-to-target-rna-base-acetylation
#4
Sunny Sharma, Jun Yang, Rob van Nues, Peter Watzinger, Peter Kötter, Denis L J Lafontaine, Sander Granneman, Karl-Dieter Entian
Box C/D snoRNAs are known to guide site-specific ribose methylation of ribosomal RNA. Here, we demonstrate a novel and unexpected role for box C/D snoRNAs in guiding 18S rRNA acetylation in yeast. Our results demonstrate, for the first time, that the acetylation of two cytosine residues in 18S rRNA catalyzed by Kre33 is guided by two orphan box C/D snoRNAs-snR4 and snR45 -not known to be involved in methylation in yeast. We identified Kre33 binding sites on these snoRNAs as well as on the 18S rRNA, and demonstrate that both snR4 and snR45 establish extended bipartite complementarity around the cytosines targeted for acetylation, similar to pseudouridylation pocket formation by the H/ACA snoRNPs...
May 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28526110/pulmonary-artery-sealing-with-ultrasonic-energy-in-open-lobectomy-a-phase-i-clinical-trial
#5
Eric Goudie, Vicky Thiffault, Adeline Jouquan, Edwin Lafontaine, Pasquale Ferraro, Moishe Liberman
OBJECTIVE: Pulmonary artery branch sealing in video-assisted thoracoscopic surgical lobectomy is usually achieved with vascular endostaplers. Iatrogenic pulmonary artery injury may be caused by endostaplers. We evaluated the safety of pulmonary artery sealing with an ultrasonic energy vessel-sealing device in a phase I clinical trial evaluating in vivo safety of the device during open lobectomy. METHODS: Patients scheduled to undergo elective open (thoracotomy) pulmonary lobectomy were prospectively enrolled...
June 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28520932/translational-control-and-rho-dependent-transcription-termination-are-intimately-linked-in-riboswitch-regulation
#6
Laurène Bastet, Adrien Chauvier, Navjot Singh, Antony Lussier, Anne-Marie Lamontagne, Karine Prévost, Eric Massé, Joseph T Wade, Daniel A Lafontaine
Riboswitches are regulatory elements that control gene expression by altering RNA structure upon the binding of specific metabolites. Although Bacillus subtilis riboswitches have been shown to control premature transcription termination, less is known about regulatory mechanisms employed by Escherichia coli riboswitches, which are predicted to regulate mostly at the level of translation initiation. Here, we present experimental evidence suggesting that the majority of known E. coli riboswitches control transcription termination by using the Rho transcription factor...
May 18, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28507073/antibodies-against-in-vivo-expressed-antigens-are-sufficient-to-protect-against-lethal-aerosol-infection-with-burkholderia-mallei-and-burkholderia-pseudomallei
#7
Shawn M Zimmerman, Jeremy S Dyke, Tomislav P Jelesijevic, Frank Michel, Eric R Lafontaine, Robert J Hogan
Burkholderia mallei, a facultative intracellular bacterium and Tier 1 biothreat, causes the fatal zoonotic disease glanders. The organism possesses multiple genes encoding autotransporter proteins, which represent important virulence factors and targets for developing countermeasures in pathogenic Gram-negative bacteria. In the present study, we investigated one of these autotransporters, BatA, and demonstrate that it displays lipolytic activity, aids in intracellular survival, is expressed in vivo, elicits production of antibodies during infection, and contributes to pathogenicity in a mouse aerosol challenge model...
May 15, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28401828/preoccupied-but-not-dismissing-attachment-states-of-mind-are-associated-with-nonsuicidal-self-injury
#8
Jodi Martin, Jean-François Bureau, Marie-France Lafontaine, Paula Cloutier, Celia Hsiao, Dominique Pallanca, Paul Meinz
In this investigation the factor structure of the Adult Attachment Interview was studied in a partially at-risk sample of 120 young adults. More specifically, 60 participants had engaged in nonsuicidal self-injury (NSSI; 53 females, M age = 20.38 years), and 60 were non-self-injuring controls matched by age and sex. Theoretically anticipated differential associations between preoccupied (but not dismissing) states of mind and NSSI were then examined. Exploratory factor analyses identified evidence for two weakly correlated state of mind dimensions (i...
May 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28389394/kinetically-accessible-yield-kay-for-redirection-of-metabolism-to-produce-exo-metabolites
#9
Jimmy G Lafontaine Rivera, Matthew K Theisen, Po-Wei Chen, James C Liao
The product formation yield (product formed per unit substrate consumed) is often the most important performance indicator in metabolic engineering. Until now, the actual yield cannot be predicted, but it can be bounded by its maximum theoretical value. The maximum theoretical yield is calculated by considering the stoichiometry of the pathways and cofactor regeneration involved. Here we found that in many cases, dynamic stability becomes an issue when excessive pathway flux is drawn to a product. This constraint reduces the yield and renders the maximal theoretical yield too loose to be predictive...
April 5, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/28371731/proteomic-response-of-macrobrachium-rosenbergii-hepatopancreas-exposed-to-chlordecone-identification-of-endocrine-disruption-biomarkers
#10
Anne Lafontaine, Dominique Baiwir, Célia Joaquim-Justo, Edwin De Pauw, Soazig Lemoine, Céline Boulangé-Lecomte, Joëlle Forget-Leray, Jean-Pierre Thomé, Eric Gismondi
The present work is the first study investigating the impacts of chlordecone, an organochlorine insecticide, on the proteome of the decapod crustacean Macrobrachium rosenbergii, by gel-free proteomic analysis. The hepatopancreas protein expression variations were analysed in organisms exposed to three environmental relevant concentrations of chlordecone (i.e. 0.2, 2 and 20µg/L). Results revealed that 62 proteins were significantly up- or down-regulated in exposed prawns compared to controls. Most of these proteins are involved in important physiological processes such as ion transport, defense mechanisms and immune system, cytoskeleton dynamics, or protein synthesis and degradation...
March 31, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28330777/altered-visual-repetition-suppression-in-fragile-x-syndrome-new-evidence-from-erps-and-oscillatory-activity
#11
Simon Rigoulot, Inga S Knoth, Marc-Philippe Lafontaine, Phetsamone Vannasing, Philippe Major, Sébastien Jacquemont, Jacques L Michaud, Karim Jerbi, Sarah Lippé
Fragile X Syndrome (FXS) is a neurodevelopmental genetic disorder associated with cognitive and behavioural deficits. In particular, neuronal habituation processes have been shown to be altered in FXS patients. Yet, while such deficits have been primarily explored using auditory stimuli, less is known in the visual modality. Here, we investigated the putative alteration of repetition suppression using faces in FXS patients compared to controls that had the same age distribution. Electroencephalographic (EEG) signals were acquired while participants were presented with 18 different faces, each repeated ten times successively...
March 19, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28287730/discovery-of-n-3r-4r-4-fluoro-1-6-3-methoxy-1-methyl-1h-pyrazol-4-yl-amino-9-methyl-9h-purin-2-yl-pyrrolidine-3-yl-acrylamide-pf-06747775-through-structure-based-drug-design-a-high-affinity-irreversible-inhibitor-targeting-oncogenic-egfr-mutants-with-selectivity
#12
Simon Planken, Douglas C Behenna, Sajiv K Nair, Theodore O Johnson, Asako Nagata, Chau Almaden, Simon Bailey, T Eric Ballard, Louise Bernier, Hengmiao Cheng, Sujin Cho-Schultz, Deepak Dalvie, Judith G Deal, Dac M Dinh, Martin P Edwards, Rose Ann Ferre, Ketan S Gajiwala, Michelle Hemkens, Robert S Kania, John C Kath, Jean Matthews, Brion W Murray, Sherry Niessen, Suvi T M Orr, Mason Pairish, Neal W Sach, Hong Shen, Manli Shi, James Solowiej, Khanh Tran, Elaine Tseng, Paolo Vicini, Yuli Wang, Scott L Weinrich, Ru Zhou, Michael Zientek, Longqing Liu, Yiqin Luo, Shuibo Xin, Chengyi Zhang, Jennifer Lafontaine
Mutant epidermal growth factor receptor (EGFR) is a major driver of non-small-cell lung cancer (NSCLC). Marketed first generation inhibitors, such as erlotinib, effect a transient beneficial response in EGFR mutant NSCLC patients before resistance mechanisms render these inhibitors ineffective. Secondary oncogenic EGFR mutations account for approximately 50% of relapses, the most common being the gatekeeper T790M substitution that renders existing therapies ineffective. The discovery of PF-06459988 (1), an irreversible pyrrolopyrimidine inhibitor of EGFR T790M mutants, was recently disclosed...
April 13, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28228566/reduced-cognitive-function-in-patients-with-parkinson-disease-and-obstructive-sleep-apnea
#13
Victoria P Mery, Priti Gros, Anne-Louise Lafontaine, Ann Robinson, Andrea Benedetti, R John Kimoff, Marta Kaminska
OBJECTIVE: To assess the association between obstructive sleep apnea (OSA) and nonmotor symptoms (NMS), including cognitive dysfunction, in patients with Parkinson disease (PD). METHODS: Patients with idiopathic PD, recruited from a movement disorder clinic, underwent overnight polysomnography. OSA was defined as an apnea-hypopnea index (AHI) ≥15/h. PD severity was assessed using the Hoehn & Yahr (H&Y) scale and the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS)...
March 21, 2017: Neurology
https://www.readbyqxmd.com/read/28209210/a-direct-observation-method-for-auditing-large-urban-centers-using-stratified-sampling-mobile-gis-technology-and-virtual-environments
#14
Sean J V Lafontaine, M Sawada, Elizabeth Kristjansson
BACKGROUND: With the expansion and growth of research on neighbourhood characteristics, there is an increased need for direct observational field audits. Herein, we introduce a novel direct observational audit method and systematic social observation instrument (SSOI) for efficiently assessing neighbourhood aesthetics over large urban areas. METHODS: Our audit method uses spatial random sampling stratified by residential zoning and incorporates both mobile geographic information systems technology and virtual environments...
February 16, 2017: International Journal of Health Geographics
https://www.readbyqxmd.com/read/28187532/testicular-sperm-aspiration-tesa-for-infertile-couples-with-severe-or-complete-asthenozoospermia
#15
A H Al-Malki, K Alrabeeah, E Mondou, V Brochu-Lafontaine, S Phillips, A Zini
The aim of the study was to evaluate reproductive outcomes in a cohort of infertile couples with severe and complete asthenozoospermia undergoing TESA (testicular sperm aspiration) with ICSI. We conducted a retrospective study of 28 couples with complete or severe asthenozoospermia who underwent TESA between January 2010 and December 2015. We compared TESA-ICSI outcomes of these couples to ejaculate ICSI outcomes of 40 couples with severe asthenozoospermia treated during the same time period at our institution...
March 2017: Andrology
https://www.readbyqxmd.com/read/28160690/use-of-concurrent-mixed-methods-combining-concept-mapping-and-focus-groups-to-adapt-a-health-equity-tool-in-canada
#16
Anne Guichard, Émilie Tardieu, Christian Dagenais, Kareen Nour, Ginette Lafontaine, Valéry Ridde
The aim of this project was to identify and prioritize a set of conditions to be considered for incorporating a health equity tool into public health practice. Concept mapping and focus groups were implemented as complementary methods to investigate the conditions of use of a health equity tool by public health organizations in Quebec. Using a hybrid integrated research design is a richer way to address the complexity of questions emerging from intervention and planning settings. This approach provides a deeper, operational, and contextualized understanding of research results involving different professional and organizational cultures, and thereby supports the decision-making process...
January 7, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/28146328/many-places-called-home-the-adaptive-value-of-seasonal-adjustments-in-range-fidelity
#17
Alexandre Lafontaine, Pierre Drapeau, Daniel Fortin, Martin-Hugues St-Laurent
The vast majority of animal species display range fidelity, a space-use behaviour enhancing familiarity with local habitat features. While the fitness benefits of this behaviour have been demonstrated in a variety of taxa, some species or populations rather display infidelity, displacing their home range over time. Others, such as many ungulate species, show seasonal adjustments in their range fidelity to accommodate changes in the dominance of limiting factors or in the distribution of resources. Few empirical studies have explored the adaptive value of seasonal adjustments in range fidelity...
February 1, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28120101/virus-induced-gene-silencing-in-rauwolfia-species
#18
Cyrielle Corbin, Florent Lafontaine, Liuda Johana Sepúlveda, Ines Carqueijeiro, Martine Courtois, Arnaud Lanoue, Thomas Dugé de Bernonville, Sébastien Besseau, Gaëlle Glévarec, Nicolas Papon, Lucia Atehortúa, Nathalie Giglioli-Guivarc'h, Marc Clastre, Benoit St-Pierre, Audrey Oudin, Vincent Courdavault
Elucidation of the monoterpene indole alkaloid biosynthesis has recently progressed in Apocynaceae through the concomitant development of transcriptomic analyses and reverse genetic approaches performed by virus-induced gene silencing (VIGS). While most of these tools have been primarily adapted for the Madagascar periwinkle (Catharanthus roseus), the VIGS procedure has scarcely been used on other Apocynaceae species. For instance, Rauwolfia sp. constitutes a unique source of specific and valuable monoterpene indole alkaloids such as the hypertensive reserpine but are also well recognized models for studying alkaloid metabolism, and as such would benefit from an efficient VIGS procedure...
July 2017: Protoplasma
https://www.readbyqxmd.com/read/28119796/distal-radius-fractures-do-not-displace-following-splint-or-cast-removal-in-the-acute-postreduction-period-a-prospective-observational-study
#19
Brock D Foster, Lakshmanan Sivasundaram, Nathanael Heckmann, William C Pannell, Ram K Alluri, Alidad Ghiassi
Background Displacement of distal radius fractures has been previously described in the literature; however, little is known about fracture displacement following splint or cast removal at the initial clinic visit following reduction and immobilization. Purpose The purpose of this study was to evaluate risk factors for fracture displacement following splint or cast removal and physical examination in the acute postinjury period. Methods All patients with a closed distal radius fracture who presented to our orthopedic hand clinic within 3 weeks of injury were prospectively enrolled in our study...
February 2017: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/28094274/folivory-elicits-a-strong-defense-reaction-in-catharanthus-roseus-metabolomic-and-transcriptomic-analyses-reveal-distinct-local-and-systemic-responses
#20
Thomas Dugé de Bernonville, Inês Carqueijeiro, Arnaud Lanoue, Florent Lafontaine, Paloma Sánchez Bel, Franziska Liesecke, Karine Musset, Audrey Oudin, Gaëlle Glévarec, Olivier Pichon, Sébastien Besseau, Marc Clastre, Benoit St-Pierre, Victor Flors, Stéphane Maury, Elisabeth Huguet, Sarah E O'Connor, Vincent Courdavault
Plants deploy distinct secondary metabolisms to cope with environment pressure and to face bio-aggressors notably through the production of biologically active alkaloids. This metabolism-type is particularly elaborated in Catharanthus roseus that synthesizes more than a hundred different monoterpene indole alkaloids (MIAs). While the characterization of their biosynthetic pathway now reaches completion, still little is known about the role of MIAs during biotic attacks. As a consequence, we developed a new plant/herbivore interaction system by challenging C...
January 17, 2017: Scientific Reports
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