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https://www.readbyqxmd.com/read/28094274/folivory-elicits-a-strong-defense-reaction-in-catharanthus-roseus-metabolomic-and-transcriptomic-analyses-reveal-distinct-local-and-systemic-responses
#1
Thomas Dugé de Bernonville, Inês Carqueijeiro, Arnaud Lanoue, Florent Lafontaine, Paloma Sánchez Bel, Franziska Liesecke, Karine Musset, Audrey Oudin, Gaëlle Glévarec, Olivier Pichon, Sébastien Besseau, Marc Clastre, Benoit St-Pierre, Victor Flors, Stéphane Maury, Elisabeth Huguet, Sarah E O'Connor, Vincent Courdavault
Plants deploy distinct secondary metabolisms to cope with environment pressure and to face bio-aggressors notably through the production of biologically active alkaloids. This metabolism-type is particularly elaborated in Catharanthus roseus that synthesizes more than a hundred different monoterpene indole alkaloids (MIAs). While the characterization of their biosynthetic pathway now reaches completion, still little is known about the role of MIAs during biotic attacks. As a consequence, we developed a new plant/herbivore interaction system by challenging C...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28071751/transcriptional-pausing-at-the-translation-start-site-operates-as-a-critical-checkpoint-for-riboswitch-regulation
#2
Adrien Chauvier, Frédéric Picard-Jean, Jean-Christophe Berger-Dancause, Laurène Bastet, Mohammad Reza Naghdi, Audrey Dubé, Pierre Turcotte, Jonathan Perreault, Daniel A Lafontaine
On the basis of nascent transcript sequencing, it has been postulated but never demonstrated that transcriptional pausing at translation start sites is important for gene regulation. Here we show that the Escherichia coli thiamin pyrophosphate (TPP) thiC riboswitch contains a regulatory pause site in the translation initiation region that acts as a checkpoint for thiC expression. By biochemically probing nascent transcription complexes halted at defined positions, we find a narrow transcriptional window for metabolite binding, in which the downstream boundary is delimited by the checkpoint...
January 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28070316/consumers-preferences-for-fresh-yam-a-focus-group-study
#3
Carla Barlagne, Denis Cornet, Jean-Marc Blazy, Jean-Louis Diman, Harry Ozier-Lafontaine
In West and Central Africa and in the Caribbean, yam is one of the most important sources of carbohydrates and has a great potential to improve food security. The yam production sector is, however, now challenged by the satisfaction of evolving consumers' preferences. Since little is known about consumers' preferences regarding yams' characteristics, product quality, and the drivers of yam purchase, six focus group discussions were conducted (for a total of 31 participants). Among the purchasing criteria, price was considered more important than the others...
January 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28031474/field-evaluation-of-insecticides-for-control-of-cabbage-maggot-diptera-anthomyiidae-in-rutabaga-in-canada
#4
W G van Herk, R S Vernon, D R Waterer, J H Tolman, P J Lafontaine, R P Prasad
At the time of this research, there were only two insecticides registered for control of cabbage maggot, Delia radicum L., in rutabaga in Canada, one of which (diazinon) will be deregistered by 2017, and resistance having been reported in some areas for the other (chlorpyrifos). To screen for chemistries to replace these organophosphates, and obtain efficacy data comparable between key vegetable brassica production areas in Canada, four small plot field studies were conducted concurrently in British Columbia, Saskatchewan, Ontario, and Quebec in 2009...
December 28, 2016: Journal of Economic Entomology
https://www.readbyqxmd.com/read/27997704/two-year-follow-up-outcomes-in-emotionally-focused-couple-therapy-an-investigation-of-relationship-satisfaction-and-attachment-trajectories
#5
Stephanie A Wiebe, Susan M Johnson, Marie-France Lafontaine, Melissa Burgess Moser, Tracy L Dalgleish, Giorgio A Tasca
Emotionally Focused Couple Therapy (EFT; The practice of emotionally focused couple therapy: Creating connection. New York, NY: Brunner-Routledge) is an evidence-based couple therapy that aims to create lasting change for couples (Clinical Psychology: Science and Practice, 6(1), 67-79). Although studies have demonstrated strong results in follow-up (Journal of Marital and Family Therapy, 28(4), 391-398), less is known about relationship functioning across time after therapy has ended. We modelled change in relationship satisfaction and attachment from pre-therapy through 24 months follow-up in 32 couples...
December 20, 2016: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/27941652/functional-divergence-of-poplar-histidine-aspartate-kinase-hk1-paralogs-in-response-to-osmotic-stress
#6
François Héricourt, Françoise Chefdor, Inès Djeghdir, Mélanie Larcher, Florent Lafontaine, Vincent Courdavault, Daniel Auguin, Franck Coste, Christiane Depierreux, Mirai Tanigawa, Tatsuya Maeda, Gaëlle Glévarec, Sabine Carpin
Previous works have shown the existence of protein partnerships belonging to a MultiStep Phosphorelay (MSP) in Populus putatively involved in osmosensing. This study is focused on the identification of a histidine-aspartate kinase, HK1b, paralog of HK1a. The characterization of HK1b showed its ability to homo- and hetero-dimerize and to interact with a few Histidine-containing Phosphotransfer (HPt) proteins, suggesting a preferential partnership in poplar MSP linked to drought perception. Furthermore, determinants for interaction specificity between HK1a/1b and HPts were studied by mutagenesis analysis, identifying amino acids involved in this specificity...
December 8, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27935785/romantic-attachment-and-physical-intimate-partner-violence-perpetration-in-a-chilean-sample-the-mediating-role-of-emotion-regulation-difficulties
#7
Mnica Guzmn-Gonzlez, Marie-France Lafontaine, Christine Levesque
Despite evidence that adult attachment insecurity has been linked to the perpetration of physical intimate violence, the mechanisms underlying this link need further exploration. The goal of this study was to evaluate the mediating role of emotion regulation difficulties in the association between romantic attachment and the use of physical intimate partner violence. To this end, 611 students recruited from Chilean universities completed the Experiences in Close Relationships questionnaire, the Difficulties in Emotion Regulation Scale, and the Revised Conflict Tactics Scales...
October 2016: Violence and Victims
https://www.readbyqxmd.com/read/27932974/patterns-of-longitudinal-neural-activity-linked-to-different-cognitive-profiles-in-parkinson-s-disease
#8
Atsuko Nagano-Saito, Mohamed S Al-Azzawi, Alexandru Hanganu, Clotilde Degroot, Béatriz Mejia-Constain, Christophe Bedetti, Anne-Louise Lafontaine, Valérie Soland, Sylvain Chouinard, Oury Monchi
Mild cognitive impairment in Parkinson's disease (PD) has been linked with functional brain changes. Previously, using functional magnetic resonance imaging (fMRI), we reported reduced cortico-striatal activity in patients with PD who also had mild cognitive impairment (MCI) vs. those who did not (non-MCI). We followed up these patients to investigate the longitudinal effect on the neural activity. Twenty-four non-demented patients with Parkinson's disease (non-MCI: 12, MCI: 12) were included in the study. Each participant underwent two fMRIs while performing the Wisconsin Card Sorting Task 20 months apart...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27924145/demographic-characteristics-associated-with-pregnant-and-postpartum-youth-referred-for-mental-health-services-in-a-community-outreach-center
#9
Sandhaya Norris, Mark L Norris, Emily Sibbald, Tim Aubry, Megan E Harrison, Genevieve Lafontaine, Jasmine Gandhi
OBJECTIVE: Pregnancy in youth is considered high risk from a number of different standpoints. At present, limited data has explored demographic factors associated with Canadian cohorts of pregnant and postpartum youth seeking mental health services. We aimed to describe demographic characteristics associated with pregnant and postpartum youth and young adults referred for mental health services in the community and to compare this with data drawn from a hospital-based perinatal mental health clinic...
2016: Journal of the Canadian Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27918935/depressive-symptoms-in-parkinson-s-disease-correlate-with-cortical-atrophy-over-time
#10
Alexandru Hanganu, Marie-Andrée Bruneau, Clotilde Degroot, Christophe Bedetti, Béatriz Mejia-Constain, Anne-Louise Lafontaine, Sylvain Chouinard, Oury Monchi
INTRODUCTION: Depressive symptoms are very common in patients with Parkinson's disease (PD) and have a significant impact on the quality of life. METHODS: The present study analyzed the correlations between over-time changes in depressive symptoms and gray matter parameters of cortical thickness and subcortical volumes in non-demented PD patients. RESULTS: A significant correlation was observed, between increased scores for depression over time and lower cortical thickness over time in the right temporo-parietal junction, right occipital medial region, right dorsolateral prefrontal cortex, right posterior cingulate region, left middle temporal as well as left supplementary motor area...
February 2017: Brain and Cognition
https://www.readbyqxmd.com/read/27911188/tuning-the-ribosome-the-influence-of-rrna-modification-on-eukaryotic-ribosome-biogenesis-and-function
#11
Katherine E Sloan, Ahmed S Warda, Sunny Sharma, Karl-Dieter Entian, Denis L J Lafontaine, Markus T Bohnsack
rRNAs are extensively modified during their transcription and subsequent maturation in the nucleolus, nucleus and cytoplasm. RNA modifications, which are installed either by snoRNA-guided or by stand-alone enzymes, generally stabilize the structure of the ribosome. However, they also cluster at functionally important sites of the ribosome, such as the peptidyltransferase center and the decoding site, where they facilitate efficient and accurate protein synthesis. The recent identification of sites of substoichiometric 2'-O-methylation and pseudouridylation has overturned the notion that all rRNA modifications are constitutively present on ribosomes, highlighting nucleotide modifications as an important source of ribosomal heterogeneity...
December 2, 2016: RNA Biology
https://www.readbyqxmd.com/read/27816489/pkc%C3%AE-induced-phosphorylations-control-the-ability-of-fra-1-to-stimulate-gene-expression-and-cancer-cell-migration
#12
Karine Belguise, Sara Cherradi, Awa Sarr, Florence Boissière, Nathalie Boulle, Joëlle Simony-Lafontaine, Valérie Choesmel-Cadamuro, Xiaobo Wang, Dany Chalbos
The AP-1 transcription factor Fra-1 is aberrantly expressed in a large number of cancers and plays crucial roles in cancer development and progression by stimulating the expression of genes involved in these processes. However, the control of Fra-1 transactivation ability is still unclear and here we hypothesized that PKCθ-induced phosphorylation could be necessary to obtain a fully active Fra-1 protein. Using MCF7 stable cells overexpressing equivalent levels of unphosphorylated Fra-1 or PKCθ-phosphorylated Fra-1, we showed that PKCθ-induced phosphorylation of Fra-1 was crucial for the stimulation of MMP1 and IL6 expression...
January 28, 2017: Cancer Letters
https://www.readbyqxmd.com/read/27811818/a-new-paramathes-boursin-1954-lepidoptera-noctuidae-species-from-china
#13
Aidas Saldaitis, Peter Gyulai
The genera Paramathes was erected by Boursin (1954) for four Xestia-like species, however with slight differences from the Xestia Hübner in their clasping apparatuses. Later this generic name was synonymised with Xestia by Lafontaine (1998). Gyulai, Ronkay, & Saldaitis (2011) treated Paramathes as the subgenera of Xestia. The most recent revision of the Paramathes is presented in the volume 8 of the Taxonomic Atlas of the Eurasian and North African Noctuoidea (Varga et al. 2015), in which authors return to the original concept of Boursin (1954), taking into consideration the configuration of the carinal plate of aedeagus and the bar in the basal area of the vesica in the males and the flap-like shape of the two bilateral lobes of the strongly sclerotized antrum in the females...
October 10, 2016: Zootaxa
https://www.readbyqxmd.com/read/27689020/influence-of-aerobic-exercise-training-on-the-neural-correlates-of-motor-learning-in-parkinson-s-disease-individuals
#14
C Duchesne, F Gheysen, A Bore, G Albouy, A Nadeau, M E Robillard, F Bobeuf, A L Lafontaine, O Lungu, L Bherer, J Doyon
BACKGROUND: Aerobic exercise training (AET) has been shown to provide general health benefits, and to improve motor behaviours in particular, in individuals with Parkinson's disease (PD). However, the influence of AET on their motor learning capacities, as well as the change in neural substrates mediating this effect remains to be explored. OBJECTIVE: In the current study, we employed functional Magnetic Resonance Imaging (fMRI) to assess the effect of a 3-month AET program on the neural correlates of implicit motor sequence learning (MSL)...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27624704/examining-chronic-care-patient-preferences-for-involvement-in-health-care-decision-making-the-case-of-parkinson-s-disease-patients-in-a-patient-centred-clinic
#15
Natalie Zizzo, Emily Bell, Anne-Louise Lafontaine, Eric Racine
BACKGROUND: Patient-centred care is a recommended model of care for Parkinson's disease (PD). It aims to provide care that is respectful and responsive to patient preferences, values and perspectives. Provision of patient-centred care should entail considering how patients want to be involved in their care. OBJECTIVE: To understand the participation preferences of patients with PD from a patient-centred care clinic in health-care decision-making processes. DESIGN, SETTING AND PARTICIPANTS: Mixed-methods study with early-stage Parkinson's disease patients from a patient-centred care clinic...
September 14, 2016: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/27536656/fluorescence-based-strategies-to-investigate-the-structure-and-dynamics-of-aptamer-ligand-complexes
#16
REVIEW
Cibran Perez-Gonzalez, Daniel A Lafontaine, J Carlos Penedo
In addition to the helical nature of double-stranded DNA and RNA, single-stranded oligonucleotides can arrange themselves into tridimensional structures containing loops, bulges, internal hairpins and many other motifs. This ability has been used for more than two decades to generate oligonucleotide sequences, so-called aptamers, that can recognize certain metabolites with high affinity and specificity. More recently, this library of artificially-generated nucleic acid aptamers has been expanded by the discovery that naturally occurring RNA sequences control bacterial gene expression in response to cellular concentration of a given metabolite...
2016: Frontiers in Chemistry
https://www.readbyqxmd.com/read/27524361/romantic-attachment-and-physical-intimate-partner-violence-perpetration-in-a-chilean-sample-the-mediating-role-of-emotion-regulation-difficulties
#17
Mónica Guzmán-González, Marie-France Lafontaine, Christine Levesque
Despite evidence that adult attachment insecurity has been linked to the perpetration of physical intimate violence, the mechanisms underlying this link need further exploration. The goal of this study was to evaluate the mediating role of emotion regulation difficulties in the association between romantic attachment and the use of physical intimate partner violence. To this end, 611 students recruited from Chilean universities completed the Experiences in Close Relationships questionnaire, the Difficulties in Emotion Regulation Scale, and the Revised Conflict Tactics Scales...
2016: Violence and Victims
https://www.readbyqxmd.com/read/27517747/the-human-box-c-d-snornas-u3-and-u8-are-required-for-pre-rrna-processing-and-tumorigenesis
#18
Jean-Louis Langhendries, Emilien Nicolas, Gilles Doumont, Serge Goldman, Denis L J Lafontaine
Small nucleolar RNAs (snoRNAs) are emerging as a novel class of proto-oncogenes and tumor suppressors; their involvement in tumorigenesis remains unclear. The box C/D snoRNAs U3 and U8 are upregulated in breast cancers. Here we characterize the function of human U3 and U8 in ribosome biogenesis, nucleolar structure, and tumorigenesis. We show in breast (MCF-7) and lung (H1944) cancer cells that U3 and U8 are required for pre-rRNA processing reactions leading, respectively, to synthesis of the small and large ribosomal subunits...
September 13, 2016: Oncotarget
https://www.readbyqxmd.com/read/27505013/amyloid-beta-alzheimer-targets-protein-processing-lipid-rafts-and-amyloid-beta-pores
#19
REVIEW
Sage C Arbor, Mike LaFontaine, Medhane Cumbay
Amyloid beta (Aβ), the hallmark of Alzheimer's Disease (AD), now appears to be deleterious in its low number aggregate form as opposed to the macroscopic Aβ fibers historically seen postmortem. While Alzheimer targets, such as the tau protein, amyloid precursor protein (APP) processing, and immune system activation continue to be investigated, the recent discovery that amyloid beta aggregates at lipid rafts and likely forms neurotoxic pores has led to a new paradigm regarding why past therapeutics may have failed and how to design the next round of compounds for clinical trials...
March 2016: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/27470247/vitellogenin-and-vitellogenin-receptor-gene-expression-and-20-hydroxyecdysone-concentration-in-macrobrachium-rosenbergii-exposed-to-chlordecone
#20
Anne Lafontaine, Marc Hanikenne, Céline Boulangé-Lecomte, Joëlle Forget-Leray, Jean-Pierre Thomé, Eric Gismondi
Chlordecone is a persistent organochlorine pesticide widely used in Guadeloupe (French West Indies) to control the banana weevil Cosmopolites sordidus. Although it was previously highlighted that chlordecone may affect the reproduction and growth of vertebrate species, little information is available on the chlordecone effects in invertebrates. The present study investigated the effects of chlordecone on a hormone and a protein having key roles in reproduction and growth of the decapod crustacean Macrobrachium rosenbergii, by measuring the 20-hydroxyecdysone concentration, vitellogenin, and vitellogenin receptor gene expression, as well as the bioconcentration of chlordecone in exposed prawns...
October 2016: Environmental Science and Pollution Research International
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