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Mycobacterium avium complex

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https://www.readbyqxmd.com/read/28099547/primary-cutaneous-mycobacterium-avium-complex-infection-following-squamous-cell-carcinoma-excision
#1
Joseph Dyer, Jonathan Weiss, W Stephen Steiner, Julie A Barber
Primary cutaneous Mycobacterium avium complex (MAC) infection is rare, particularly among immunocompetent patients. We present the case of a purportedly healthy patient with primary cutaneous MAC infection arising within the excision margins of multiple infiltrating squamous cell carcinomas.
December 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28069470/minimal-inhibitory-concentration-distributions-for-mycobacterium-avium-complex-towards-evidence-based-susceptibility-breakpoints
#2
Thomas Schön, Erja Chryssanthou
OBJECTIVE: Patients with clinical infections caused by the Mycobacterium avium-complex (MAC) are treated for at least one year following sputum conversion with a regimen suffering from suboptimal cure rates. The correlation between clinical outcome and drug susceptibility testing breakpoints other than for the macrolides is regarded to be poor. A systematic evaluation of clinical breakpoints against MAC has not been performed so far and thus our aim was to initiate this process by establishing minimal inhibitory concentration (MIC) distributions...
January 6, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28063416/nontuberculous-mycobacterial-infection-in-rheumatoid-arthritis-patients-a-single-center-experience-in-south-korea
#3
Doo-Ho Lim, Yong-Gil Kim, Tae Sun Shim, Kyung-Wook Jo, Byeongzu Ghang, Soo Min Ahn, Seokchan Hong, Chang-Keun Lee, Bin Yoo
Background/Aims: Nontuberculous mycobacteria (NTM) infection has been increasing worldwide in both general population and immunocompromised patients, which has also been reported in rheumatoid arthritis (RA) patients. This study aimed to identify the incidence and clinical characteristics of NTM infection in RA patients living in tuberculosis (TB) infection endemic area. Methods: We performed a retrospective analysis of NTM infection cases in our RA registry at a tertiary referral center from January 1995 to December 2013...
January 6, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28056158/mycobacterium-avium-complex-septic-arthritis-presenting-as-osteonecrosis-of-the-femoral-head-in-a-patient-with-systemic-lupus-erythematosus
#4
Alexander B Christ, Elena V Zininberg, Kethy M Jules-Elysee, Michael L Parks
Mycobacterium avium complex is a rare cause of musculoskeletal infection, usually occurring in patients with compromised immune systems. Obtaining the diagnosis requires a high index of suspicion, and treatment can be delayed because of difficulty with isolating the organism. Treatment involves prolonged, targeted combination antibiotic therapy, and it is unclear whether eradication of the infection can occur in the presence of a foreign body, such as antibiotic spacers. The authors report a case of M avium infection presenting as presumed osteonecrosis of the femoral head in a young woman with systemic lupus erythematosus...
January 5, 2017: Orthopedics
https://www.readbyqxmd.com/read/28053669/mycobacterium-avium-subsp-paratuberculosis-and-associated-risk-factors-for-inflammatory-bowel-disease-in-iranian-patients
#5
Samin Zamani, Mohammad Reza Zali, Hamid Asadzadeh Aghdaei, Leonardo Antonio Sechi, Magdalena Niegowska, Elisa Caggiu, Rouhollah Keshavarz, Nader Mosavari, Mohammad Mehdi Feizabadi
BACKGROUND: Inflammatory bowel disease (IBD) is described as a relapsing condition with high morbidity and uncertain complex pathogenesis. The association of Mycobacterium avium ssp. paratuberculosis (MAP) with Crohn's disease (CD) in human has been debated for decades, however there is no confirmed data to verify such relations in Iran. The aim of this study was to investigate risk factors and a possible role of MAP in Iranian patients with CD. METHODS: Anti-MAP antibodies were detected in serum of IBD patients and subjects without IBD (nIBD) through ELISA; MAP DNA and viable MAP cells were identified in patients' biopsies through nested PCR and direct culture methods, respectively...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28043575/rapid-identification-of-mycobacterium-avium-ssp-paratuberculosis-laboratory-strains-by-is900-nested-polymerase-chain-reaction
#6
Mohammad Mohammad Taheri, Nader Mosavari, Mohammad Mehdi Feizabadi, Keyvan Tadayon, Rouholah Keshavarz, Reza Aref Pajoohi, Kioomars Soleimani, Shojaat Dashti Pour
INTRODUTION: Mycobacterium avium ssp paratuberculosis (MAP) causes paratuberculosis (Johne's disease) in ruminants. As a species, M. avium comprises M. avium subsp. hominissuis and a number of clones that are known to have evolved from this subspecies, namely M. avium subsp. avium (MAA), M. avium subsp. silvaticum, and MAP. Despite the very high genomic similarity of MAP and MAA, the insertion sequence IS900, which is 1,451-bp long, is now understood to be exclusively present in 10-20 copies in the genome of MAP...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043565/drug-susceptibility-testing-of-mycobacterium-avium-subsp-avium-isolates-from-naturally-infected-domestic-pigeons-to-avian-tuberculosis
#7
Kaveh Parvandar, Mansour Mayahi, Nader Mosavari, Reza Aref Pajoohi
OBJECTIVE: Avian tuberculosis is one of the most important infections affecting most species of birds. Several mycobacterial species have been identified causing avian tuberculosis, and the organisms confirmed most frequently are Mycobacterium avium and Mycobacterium genavense. Any species of birds can be infected with M. avium. Generally, domesticated fowl or captive wild birds are affected more frequently than those living in the wild. M. avium can not only infect all species of birds, but can also infect some domesticated mammals to cause disease, usually with localized lesion...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28031437/antibody-levels-against-glycopeptidolipid-core-as-a-marker-for-monitoring-treatment-response-in-mycobacterium-avium-complex-pulmonary-disease-a-prospective-cohort-study
#8
Seigo Kitada, Ryoji Maekura, Kenji Yoshimura, Keisuke Miki, Mari Miki, Yohei Oshitani, Kohei Nishida, Nobuhiko Sawa, Masahide Mori, Kazuo Kobayashi
The diagnosis of Mycobacterium avium complex pulmonary disease (MAC-PD) is sometimes complicated and time-consuming. A serodiagnostic kit that measures the serum levels of IgA antibodies against the glycopeptidolipid (GPL) core is commercially available and has good diagnostic accuracy for MAC-PD. However, the significance of measurement of GPL core IgA antibody levels in monitoring for chemotherapy response in patients with MAC-PD was not well investigated.Thirty-four treatment naïve MAC-PD patients who were started on multidrug chemotherapy were enrolled...
December 28, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28012493/analysis-of-the-impact-of-lung-cancer-treatment-on-nontuberculous-mycobacterial-lung-diseases
#9
Taisuke Tsuji, Kazunari Tsuyuguchi, Kazunobu Tachibana, Yohei Kimura, Takehiko Kobayashi, Shojiro Minomo, Shinji Atagi, Akihide Matsumura, Seiji Hayashi, Katsuhiro Suzuki
BACKGROUND: Although nontuberculous mycobacteria (NTM) lung diseases can occur in association with lung cancer, no study has evaluated the effect of lung cancer treatment on NTM lung diseases. Therefore, the present study aimed to retrospectively examine the effect of lung cancer treatment on NTM lung diseases. METHODS: Patients diagnosed with NTM lung diseases in combination with cytologically or histologically proven lung cancer between January 1, 2010 and October 31, 2014 were enroled...
January 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28000919/antibiotic-treatment-for-nontuberculous-mycobacteria-lung-infection-in-people-with-cystic-fibrosis
#10
REVIEW
Valerie Waters, Felix Ratjen
BACKGROUND: Nontuberculous mycobacteria are mycobacteria, other than those in the Mycobacterium tuberculosis complex, and are commonly found in the environment. Nontuberculous mycobacteria species (most commonly Mycobacterium avium complex and Mycobacterium abscessus) are isolated from the respiratory tract of approximately 5% to 40% of individuals with cystic fibrosis; they can cause lung disease in people with cystic fibrosis leading to more a rapid decline in lung function and even death in certain circumstances...
December 19, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28000104/immune-reconstitution-inflammatory-syndrome-presenting-as-mycobacterium-avium-complex-lymphadenitis
#11
Ashley Matusz-Fisher, Wesley Bodie, Thomas Montgomery
No abstract text is available yet for this article.
December 20, 2016: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/27984010/nothing-to-s-cough-at-pulmonary-mycobacterium-avium-complex-infection
#12
Michael A Santos, Hardikkumar Patel, Adam Albert
No abstract text is available yet for this article.
October 28, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27971536/the-cost-of-remaining-ntm-positive-health-care-utilization-and-costs-in-a-sample-of-patients-with-refractory-pulmonary-disease-due-to-mycobacterium-avium-complex-in-canada-germany-united-kingdom-and-france
#13
S M Goring, N Risebrough, J B Wilson, J Watch, J R Gallagher, K J Heap, S Carroll, M Obradovic
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27934821/drug-susceptibility-of-rapid-and-slow-growing-non-tuberculous-mycobacteria-isolated-from-symptomatics-for-pulmonary-tuberculosis-central-india
#14
B Goswami, P Narang, P S Mishra, R Narang, U Narang, D K Mendiratta
BACKGROUND: Non-tuberculous mycobacteria (NTM) are emerging as important pathogens. Their treatment also differs from that of Mycobacterium tuberculosis. In India, any datum on them is scarce as species identification and drug susceptibility are not performed in most laboratories. Susceptibility also differs from one geographic area to another, and in our country, there are no data even to guide the clinicians to start treatment empirically. METHODOLOGY: The present study endeavours to generate drug susceptibility data on NTM isolated from sputum samples collected and stored from 6445 symptomatics for pulmonary tuberculosis during a prevalence survey and from specimens received from the hospital...
October 2016: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27928399/spectrum-and-clinical-course-of-visual-field-abnormalities-in-ethambutol-toxicity
#15
Thomas Mendel, David Fleischman, R Rand Allingham, Henry Tseng, David A Chesnutt
Visual toxicities from ethambutol are rare but represent one of the few causes of non-glaucomatous and non-compressive bitemporal hemianopsia. The authors present a six-patient case series illustrating variable clinical presentation and reversibility of visual loss in patients treated with ethambutol for Mycobacterium avium complex, including four patients who presented with visual field defects suggestive of bitemporal hemianopsia. Two additional patients were being followed for glaucoma, developed visual field defects with ethambutol treatment, and subsequently recovered with cessation of drug...
June 2016: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27918379/nontuberculous-mycobacteria-in-children-a-focus-on-bloodstream-infections
#16
Laila S Al Yazidi, Ben J Marais, Briony Hazelton, Alexander Outhred, Alison Kesson
BACKGROUND: Nontuberculous mycobacteria (NTM) are ubiquitous organisms with variable disease-causing potential. Bloodstream infections caused by NTM in children are poorly described. METHODS: We describe a retrospective case series of children with culture-confirmed mycobacterial disease managed at The Children's Hospital at Westmead from July 2005 - June 2015. RESULTS: Sixty-five patients had 149 positive NTM cultures; 55 (83.0%) episodes in 54 patients were considered clinically significant...
December 1, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27915421/the-frequency-and-treatment-of-pneumothorax-associated-with-pulmonary-nontuberculous-mycobacterial-infection
#17
Masaki Ikeda, Koji Takahashi, Teruya Komatsu, Toru Tanaka, Tatsuo Kato, Takuji Fujinaga
OBJECTIVES: Characteristics of pneumothorax associated with nontuberculous mycobacterium (NTM) infection are rarely reported, especially in terms of surgical treatments. Our objectives were to show the tendency and clinical courses of pneumothorax due to NTM and discuss the way of therapy in our hospital. METHODS: We retrospectively analyzed 557 patients with NTM infection over a period of 5 years at the Nagara Medical Center. RESULTS: A total of 12 out of the 557 patients (2...
December 3, 2016: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27915187/dose-response-models-and-a-quantitative-microbial-risk-assessment-framework-for-the-mycobacterium-avium-complex-that-account-for-recent-developments-in-molecular-biology-taxonomy-and-epidemiology
#18
REVIEW
Kerry A Hamilton, Mark H Weir, Charles N Haas
Mycobacterium avium complex (MAC) is a group of environmentally-transmitted pathogens of great public health importance. This group is known to be harbored, amplified, and selected for more human-virulent characteristics by amoeba species in aquatic biofilms. However, a quantitative microbial risk assessment (QMRA) has not been performed due to the lack of dose response models resulting from significant heterogeneity within even a single species or subspecies of MAC, as well as the range of human susceptibilities to mycobacterial disease...
February 1, 2017: Water Research
https://www.readbyqxmd.com/read/27911922/nucleic-acid-amplification-testing-and-sequencing-combined-with-acid-fast-staining-in-needle-biopsy-lung-tissues-for-the-diagnosis-of-smear-negative-pulmonary-tuberculosis
#19
Faming Jiang, Weiwei Huang, Ye Wang, Panwen Tian, Xuerong Chen, Zongan Liang
BACKGROUND: Smear-negative pulmonary tuberculosis (PTB) is common and difficult to diagnose. In this study, we investigated the diagnostic value of nucleic acid amplification testing and sequencing combined with acid-fast bacteria (AFB) staining of needle biopsy lung tissues for patients with suspected smear-negative PTB. METHODS: Patients with suspected smear-negative PTB who underwent percutaneous transthoracic needle biopsy between May 1, 2012, and June 30, 2015, were enrolled in this retrospective study...
2016: PloS One
https://www.readbyqxmd.com/read/27908271/host-directed-therapeutics-against-mycobacterial-infections
#20
Haruaki Tomioka, Chiaki Sano, Yutaka Tatano
The high incidence of tuberculosis (TB) in the world, especially in developing countries, the resurgence of TB in industrialized countries, and the global increase in the prevalence of Mycobacterium avium complex infections in immunocompromised hosts have prompted the quest for novel antimycobacterial drugs. However, the development of such antimicrobial chemotherapeutics is currently making very slow progress even with using the bioinformatics-based methodology for drug design. It thus appears that devising improved administration protocols for clinical treatment against intractable mycobacterial infections using existing chemotherapeutics is more practical than awaiting the development of new antimycobacterial drugs...
December 2, 2016: Current Pharmaceutical Design
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