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Mycobacterium avium complex

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https://www.readbyqxmd.com/read/29121801/usefulness-of-chinese-herbal-medicines-as-host-directed-therapeutics-against-mycobacterial-infections-a-review
#1
Haruaki Tomioka
The high incidence of tuberculosis (TB) in developing countries, the resurgence of TB in industrialized countries, and the world-wide increase in the prevalence of Mycobacterium avium complex infections have prompted the quest for new antimycobacterial drugs. However, the development of such chemotherapeutics is currently making very slow progress. It therefore appears that devising improved administration protocols for clinical treatment against intractable mycobacteriosis using existing chemotherapeutics is more practical than awaiting the development of novel antimycobacterial drugs...
November 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29120902/neutralizing-antiinterferon-%C3%AE-autoantibodies-causing-disseminated-mycobacterium-avium-complex-infection-in-an-hiv-infected-patient-on-successful-combination-antiretroviral-therapy
#2
Un-In Wu, Chien-Ching Hung, Sui-Yuan Chang, Yi-Ting Jhong, Hsin-Yun Sun, Jann-Tay Wang, Szu-Min Hsieh, Wang-Huei Sheng, Wen-Chun Liu, Shan-Chwen Chang, Yee-Chun Chen
No abstract text is available yet for this article.
November 28, 2017: AIDS
https://www.readbyqxmd.com/read/29109708/differential-identification-of-mycobacterial-species-using-high-resolution-melting-analysis
#3
Azar D Khosravi, Mohammad Hashemzadeh, Abdolrazagh Hashemi Shahraki, Ali Teimoori
Infections caused by non-tuberculous mycobacteria (NTM) is increasing wordwide. Due to the difference in treatment of NTM infections and tuberculosis, rapid species identification of mycobacterial clinical isolates is necessary for the effective management of mycobacterial diseases treatment and their control strategy. In this study, a cost-effective technique, real-time PCR coupled with high-resolution melting (HRM) analysis, was developed for the differentiation of Mycobacterial species using a novel rpoBC sequence...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29098128/hot-tub-lung-a-diagnostic-challenge
#4
Hassaan Yasin, William E Mangano, Paras Malhotra, Ali Farooq, Hesham Mohamed
Hot tub lung (HTL) is a granulomatous lung disease thought to occur as a result of a hypersensitivity response to non-tuberculous mycobacteria (NTM). Typical radiographic findings are diffuse micronodular and/or ground glass opacities. We report an interesting case of HTL that presented with unique radiographic features, making its diagnosis a predicament. A 56-year-old immunocompetent female with chronic dyspnea and dry cough was found to have subcentimeter cavitary nodules, predominantly in the upper lung zones...
August 27, 2017: Curēus
https://www.readbyqxmd.com/read/29093379/disseminated-cutaneous-infection-of-mycobacterium-colombiense-in-a-patient-with-myelodysplastic-syndrome-a-case-report
#5
Yuichiro Inagaki, Tatsuya Ito, Tomonori Kato, Yoshitaka Ono, Masashi Sawa
Mycobacterium colombiense (M. colombiense) is a member of the Mycobacterium avium complex (MAC). To our knowledge, this is the third case report of an M. colombiense infection. An 80-year-old man, immunocompromised by myelodysplastic syndrome (MDS), developed a skin rash with exfoliation and eruption on his face and scalp. Mycobacteria were detected in pus samples. Broad-range polymerase chain reaction (PCR) revealed the mycobacteria to be M. colombiense. The lesions resolved after daily administration of rifampicin, ethambutol, and clarithromycin...
November 1, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29059250/causative-species-of-nontuberculous-mycobacterial-lung-disease-and-comparative-investigation-on-clinical-features-of-mycobacterium-abscessus-complex-disease-a-retrospective-analysis-for-two-major-hospitals-in-a-subtropical-region-of-japan
#6
COMPARATIVE STUDY
Hiroaki Nagano, Takeshi Kinjo, Yuichiro Nei, Shin Yamashiro, Jiro Fujita, Tomoo Kishaba
Nontuberculous mycobacteria (NTM) lung disease is increasing globally. Although the etiological epidemiology of NTM is different across regions, Mycobacterium avium complex (MAC) is the leading cause of NTM lung disease in most countries, including mainland Japan. Okinawa is located in the southernmost region of Japan and is the only prefecture categorized as a subtropical region in Japan, it is therefore likely the etiological epidemiology of NTM lung disease is different from mainland Japan. From 2009 to 2015, the medical records of patients, with respiratory specimens positive for NTMs, visiting or admitted to two Okinawan hospitals, were retrospectively analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/29042494/insights-from-the-genome-sequence-of-mycobacterium-lepraemurium-massive-gene-decay-and-reductive-evolution
#7
Andrej Benjak, Tanvi P Honap, Charlotte Avanzi, Enrique Becerril-Villanueva, Iris Estrada-García, Oscar Rojas-Espinosa, Anne C Stone, Stewart T Cole
Mycobacterium lepraemurium is the causative agent of murine leprosy, a chronic, granulomatous disease similar to human leprosy. Due to the similar clinical manifestations of human and murine leprosy and the difficulty of growing both bacilli axenically, Mycobacterium leprae and M. lepraemurium were once thought to be closely related, although it was later suggested that M. lepraemurium might be related to Mycobacterium avium In this study, the complete genome of M. lepraemurium was sequenced using a combination of PacBio and Illumina sequencing...
October 17, 2017: MBio
https://www.readbyqxmd.com/read/29033435/clinical-features-of-nontuberculous-mycobacterial-pleurisy-a-review-of-12-cases
#8
Maiko Naito, Toshiya Maekura, Yu Kurahara, Masahiro Tahara, Naoya Ikegami, Yohei Kimura, Shoko Sonobe, Takehiko Kobayashi, Shojiro Minomo, Taisuke Tsuji, Kazunari Tsuyuguchi, Seiji Hayashi, Katsuhiro Suzuki
Objective The incidence of pulmonary nontuberculous mycobacterial (NTM) infections has increased in recent decades. Nevertheless, NTM pleurisy is still a rare disease. The objective of the present study was to elucidate the clinical features and outcomes of NTM pleurisy. Methods A retrospective study was undertaken of consecutive patients whose pleural effusion culture yielded NTM, from 2002 to 2016 at a respiratory hospital in Japan. The clinical features, treatment, and outcomes of these patients were analyzed...
October 16, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29017528/first-case-of-mycobacterium-marseillense-lymphadenitis-in-a-child
#9
A Azzali, C Montagnani, M T Simonetti, G Spinelli, M de Martino, L Galli
BACKGROUND: Nontuberculous mycobacteria (NTM) are pathogens that commonly affect the paediatric population and its most frequent manifestation is a cervicofacial lymphadenopathy. With the improvement of technologies, new species have been recently identified. CASE PRESENTATION: We report the first case of NMT lymphadenitis in a child caused by Mycobacterium marseillense, a newly described species belonging to Mycobacterium avium complex. CONCLUSIONS: Improving the identification of these newly discovered mycobacteria, further information will be available about their clinical involvement and their best treatment...
October 10, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28990320/non-tuberculosis-mycobacterium-speciation-using-hplc-under-revised-national-tb-control-programme-rntcp-in-india
#10
George Sebastian, Sharath Burugina Nagaraja, Telagi Vishwanatha, Mamatha Voderhobli, Narayana Vijayalakshmi, Prahlad Kumar
AIMS: Non-Tuberculous Mycobacteria (NTM) are ubiquitous in nature. The data on prevalence of NTM under the RNTCP is scarce. Many NTM species have clinical significance, and hence their identification and speciation are important. METHODS AND RESULT: It is a cross-sectional study conducted at the five RNTCP accredited culture and drug susceptibility testing (CDST) laboratory. The culture isolates from AFB positive but Immunochromatographic test negative samples were taken for identification and speciation using HPLC...
October 9, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28984546/mycobacterium-grossiae-sp-nov-a-rapidly-growing-scotochromogenic-species-isolated-from-human-clinical-respiratory-and-blood-culture-specimens
#11
Alberto Enrique Paniz-Mondolfi, Alexander L Greninger, Lynn Ladutko, Barbara A Brown-Elliott, Ravikiran Vasireddy, Wesley Jakubiec, Sruthi Vasireddy, Richard J Wallace, Keith E Simmon, Bruce E Dunn, Gary Jackoway, Surabhi B Vora, Kevin K Quinn, Xuan Qin, Sheldon Campbell
A previously undescribed, rapidly growing, scotochromogenic species of the genus Mycobacterium (represented by strains PB739(T) and GK) was isolated from two clinical sources - the sputum of a 76-year-old patient with severe chronic obstructive pulmonary disease, history of tuberculosis exposure and Mycobacterium avium complex isolated years prior; and the blood of a 15-year-old male with B-cell acute lymphoblastic leukaemia status post bone marrow transplant. The isolates grew as dark orange colonies at 25-37 °C after 5 days, sharing features in common with other closely related species...
October 6, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28968457/natural-course-of-the-nodular-bronchiectatic-form-of-mycobacterium-avium-complex-lung-disease-long-term-radiologic-change-without-treatment
#12
Tae Yun Park, Semin Chong, Jae-Woo Jung, In Won Park, Byoung Whui Choi, Changwon Lim, Chang Un Lee, Yang Soo Kim, Hye Won Choi, Jae Chol Choi
BACKGROUND/PURPOSE: Although the incidence of Mycobacterium avium complex (MAC) lung disease is increasing, the long-term natural course of the nodular bronchiectatic form of MAC lung disease is not well described. The objective of our study is to evaluate long-term radiologic changes in untreated MAC lung disease by analyzing serial chest computed tomography (CT) scan findings. METHODS: Of 104 patients with MAC lung disease, we selected 40 untreated nodular bronchiectatic MAC patients who underwent serial chest CTs without treatment for at least four years (mean = 6...
2017: PloS One
https://www.readbyqxmd.com/read/28954780/outcomes-of-mycobacterium-avium-complex-lung-disease-based-on-clinical-phenotype
#13
Won-Jung Koh, Seong Mi Moon, Su-Young Kim, Min-Ah Woo, Seonwoo Kim, Byung Woo Jhun, Hye Yun Park, Kyeongman Jeon, Hee Jae Huh, Chang-Seok Ki, Nam Yong Lee, Myung Jin Chung, Kyung Soo Lee, Sung Jae Shin, Charles L Daley, Hojoong Kim, O Jung Kwon
The effect of the clinical phenotype of Mycobacterium avium complex (MAC) lung disease on treatment outcome and redevelopment of nontuberculous mycobacterial (NTM) lung disease after treatment completion has not been studied systematically.We evaluated 481 treatment-naïve patients with MAC lung disease who underwent antibiotic treatment for ≥12 months between January 2002 and December 2013.Out of 481 patients, 278 (58%) had noncavitary nodular bronchiectatic (NB) disease, 80 (17%) had cavitary NB disease and 123 (25%) had fibrocavitary disease...
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28954776/mycobacterium-avium-complex-infection-phenotypes-and-outcomes
#14
EDITORIAL
Michael R Loebinger
No abstract text is available yet for this article.
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28932715/hemophagocytic-lymphohistiocytosis-hlh-elusive-diagnosis-of-disseminated-mycobacterium-avium-complex-infection
#15
Eloy E Ordaya, Sulieman Abu Jarir, Robert Yoo, Pranatharthi H Chandrasekar
INTRODUCTION: Hemophagocytic lymphohistiocytosis (HLH) is a clinical syndrome of hyperinflammation leading to an uncontrolled and ineffective immune response, associated with high mortality. CASE REPORT: A 26-year-old woman with acute lymphoblastic leukemia, 8 months in remission, was found to have HLH. Without any improvement, stem cell transplantation was considered. Then, Mycobacterium avium complex (MAC) infection was identified as cause of her HLH. With appropriate therapy for infection, HLH improved and transplantation was averted...
September 2017: Germs
https://www.readbyqxmd.com/read/28931915/non-tuberculous-mycobacteria-isolated-from-pulmonary-samples-in-sub-saharan-africa-a-systematic-review-and-meta-analyses
#16
Catherine Okoi, Suzanne T B Anderson, Martin Antonio, Sarah N Mulwa, Florian Gehre, Ifedayo M O Adetifa
Pulmonary non-tuberculous mycobacterial (NTM) disease epidemiology in sub-Saharan Africa is not as well described as for pulmonary tuberculosis. Earlier reviews of global NTM epidemiology only included subject-level data from one sub-Saharan Africa country. We systematically reviewed the literature and searched PubMed, Embase, Popline, OVID and Africa Wide Information for articles on prevalence and clinical relevance of NTM detection in pulmonary samples in sub-Saharan Africa. We applied the American Thoracic Society/Infectious Disease Society of America criteria to differentiate between colonisation and disease...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28930014/surveillance-of-extrapulmonary-nontuberculous-mycobacteria-infections-oregon-usa-2007-2012
#17
Emily Henkle, Katrina Hedberg, Sean D Schafer, Kevin L Winthrop
Limited data are available describing extrapulmonary nontuberculous mycobacteria (NTM) infections in the general population. We describe results from statewide population-based laboratory surveillance in Oregon, USA, during 2007-2012. We defined a case of extrapulmonary NTM infection as >1 isolate from skin/soft tissue, disseminated sites, lymph node, joint, or other sites. The annual incidence of extrapulmonary NTM infection (other than Mycobacterium gordonae) was stable, averaging 1.5 cases/100,000 population...
October 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28923675/respiratory-infections-due-to-nontuberculous-mycobacterias
#18
REVIEW
Luis Máiz Carro, Esther Barbero Herranz, Rosa Nieto Royo
The most common infections caused by nontuberculous mycobacteria (NTM) are lung infections. The microorganisms causing these infections most frequently are Mycobacterium avium complex, Mycobacterium kansasii and Mycobacterium abscessus complex. Their incidence has increased in the last three decades. After identifying an NTM in the respiratory tract, clinical and radiological aspects must be considered to determine if isolations are clinically relevant. Predisposing conditions that could contribute to infection must also be investigated...
September 15, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28922813/meta-analyses-and-the-evidence-base-for-microbial-outcomes-in-the-treatment-of-pulmonary-mycobacterium-avium-intracellulare-complex-disease
#19
Jotam G Pasipanodya, Deborah Ogbonna, Devyani Deshpande, Shashikant Srivastava, Tawanda Gumbo
Objectives: To perform a systematic review and meta-analysis of the level of funding support and the sputum culture conversion rates in pulmonary Mycobacterium avium-intracellulare complex (P-MAC) disease in adult patients without cystic fibrosis or HIV infection, treated with recommended antibiotic regimens. Methods: We performed a literature search to identify clinical trials, prospective studies and registries that reported outcomes in P-MAC patients. Studies that reported P-MAC diagnosis and treatments based on established guidelines met the inclusion criteria and were examined for bias and quality...
September 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28922812/treatment-of-mycobacterium-avium-intracellulare-complex-a-great-leap-forward
#20
Jan-Willem C Alffenaar, Jakko van Ingen
No abstract text is available yet for this article.
September 1, 2017: Journal of Antimicrobial Chemotherapy
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