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Mycobacterium avium complex

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https://www.readbyqxmd.com/read/27928399/spectrum-and-clinical-course-of-visual-field-abnormalities-in-ethambutol-toxicity
#1
Thomas Mendel, David Fleischman, R Rand Allingham, Henry Tseng, David A Chesnutt
Visual toxicities from ethambutol are rare but represent one of the few causes of non-glaucomatous and non-compressive bitemporal hemianopsia. The authors present a six-patient case series illustrating variable clinical presentation and reversibility of visual loss in patients treated with ethambutol for Mycobacterium avium complex, including four patients who presented with visual field defects suggestive of bitemporal hemianopsia. Two additional patients were being followed for glaucoma, developed visual field defects with ethambutol treatment, and subsequently recovered with cessation of drug...
June 2016: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27918379/nontuberculous-mycobacteria-in-children-a-focus-on-bloodstream-infections
#2
Laila S Al Yazidi, Ben J Marais, Briony Hazelton, Alexander Outhred, Alison Kesson
BACKGROUND: Nontuberculous mycobacteria (NTM) are ubiquitous organisms with variable disease-causing potential. Bloodstream infections caused by NTM in children are poorly described. METHODS: We describe a retrospective case series of children with culture-confirmed mycobacterial disease managed at The Children's Hospital at Westmead from July 2005 - June 2015. RESULTS: Sixty-five patients had 149 positive NTM cultures; 55 (83.0%) episodes in 54 patients were considered clinically significant...
December 1, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27915421/the-frequency-and-treatment-of-pneumothorax-associated-with-pulmonary-nontuberculous-mycobacterial-infection
#3
Masaki Ikeda, Koji Takahashi, Teruya Komatsu, Toru Tanaka, Tatsuo Kato, Takuji Fujinaga
OBJECTIVES: Characteristics of pneumothorax associated with nontuberculous mycobacterium (NTM) infection are rarely reported, especially in terms of surgical treatments. Our objectives were to show the tendency and clinical courses of pneumothorax due to NTM and discuss the way of therapy in our hospital. METHODS: We retrospectively analyzed 557 patients with NTM infection over a period of 5 years at the Nagara Medical Center. RESULTS: A total of 12 out of the 557 patients (2...
December 3, 2016: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27915187/dose-response-models-and-a-quantitative-microbial-risk-assessment-framework-for-the-mycobacterium-avium-complex-that-account-for-recent-developments-in-molecular-biology-taxonomy-and-epidemiology
#4
REVIEW
Kerry A Hamilton, Mark H Weir, Charles N Haas
Mycobacterium avium complex (MAC) is a group of environmentally-transmitted pathogens of great public health importance. This group is known to be harbored, amplified, and selected for more human-virulent characteristics by amoeba species in aquatic biofilms. However, a quantitative microbial risk assessment (QMRA) has not been performed due to the lack of dose response models resulting from significant heterogeneity within even a single species or subspecies of MAC, as well as the range of human susceptibilities to mycobacterial disease...
November 24, 2016: Water Research
https://www.readbyqxmd.com/read/27911922/nucleic-acid-amplification-testing-and-sequencing-combined-with-acid-fast-staining-in-needle-biopsy-lung-tissues-for-the-diagnosis-of-smear-negative-pulmonary-tuberculosis
#5
Faming Jiang, Weiwei Huang, Ye Wang, Panwen Tian, Xuerong Chen, Zongan Liang
BACKGROUND: Smear-negative pulmonary tuberculosis (PTB) is common and difficult to diagnose. In this study, we investigated the diagnostic value of nucleic acid amplification testing and sequencing combined with acid-fast bacteria (AFB) staining of needle biopsy lung tissues for patients with suspected smear-negative PTB. METHODS: Patients with suspected smear-negative PTB who underwent percutaneous transthoracic needle biopsy between May 1, 2012, and June 30, 2015, were enrolled in this retrospective study...
2016: PloS One
https://www.readbyqxmd.com/read/27908271/host-directed-therapeutics-against-mycobacterial-infections
#6
Haruaki Tomioka, Chiaki Sano, Yutaka Tatano
The high incidence of tuberculosis (TB) in the world, especially in developing countries, the resurgence of TB in industrialized countries, and the global increase in the prevalence of Mycobacterium avium complex infections in immunocompromised hosts have prompted the quest for novel antimycobacterial drugs. However, the development of such antimicrobial chemotherapeutics is currently making very slow progress even with using the bioinformatics-based methodology for drug design. It thus appears that devising improved administration protocols for clinical treatment against intractable mycobacterial infections using existing chemotherapeutics is more practical than awaiting the development of new antimycobacterial drugs...
December 2, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27902391/comparative-evaluation-of-the-advansure-mycobacteria-genoblot-assay-and-the-genotype-mycobacterium-cm-as-assay-for-the-identification-of-nontuberculous-mycobacteria
#7
Mina Yang, Hee Jae Huh, Hyeon Jeong Kwon, Ji-Youn Kim, Dong Joon Song, Won-Jung Koh, Chang-Seok Ki, Nam Yong Lee
In this study, to assess the performance of the AdvanSure Mycobacteria GenoBlot Assay (AdvanSure assay), we compared its performance with that of the GenoType Mycobacterium CM/AS assay (GenoType assay) for the identification of nontuberculous mycobacteria (NTM). Twenty-four reference strains and 103 consecutive clinical NTM isolates were analyzed. The accuracy rates for the 24 reference strains were 87.5% and 95.8% for the AdvanSure and GenoType assays respectively. For the 103 clinical isolates, a 91.3% (94/103) concordance rate was observed between the two assays...
October 24, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27901051/mycobacterium-avium-mav2054-protein-induces-macrophage-apoptosis-by-targeting-mitochondria-and-reduces-intracellular-bacterial-growth
#8
Kang-In Lee, Jake Whang, Han-Gyu Choi, Yeo-Jin Son, Haet Sal Jeon, Yong Woo Back, Hye-Soo Park, Seungwha Paik, Jeong-Kyu Park, Chul Hee Choi, Hwa-Jung Kim
Mycobacterium avium complex induces macrophage apoptosis. However, the M. avium components that inhibit or trigger apoptosis and their regulating mechanisms remain unclear. We recently identified the immunodominant MAV2054 protein by fractionating M. avium culture filtrate protein by multistep chromatography; this protein showed strong immuno-reactivity in M. avium complex pulmonary disease and in patients with tuberculosis. Here, we investigated the biological effects of MAV2054 on murine macrophages. Recombinant MAV2054 induced caspase-dependent macrophage apoptosis...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27882275/a-case-of-an-enigmatic-pulmonary-infiltrate
#9
Uroosa Ibrahim, Amina Saqib, Michel Chalhoub, Jean Paul Atallah
The differential diagnosis of a pulmonary mass in an immunosuppressed host with a history of cancer is broad and includes malignant, infectious and inflammatory etiologies. Mycobacterium avium complex (MAC) is a rare cause of opportunistic infection in susceptible individuals that can present as either localized or disseminated disease. On radiologic studies, the pulmonary disease can manifest as heterogeneous linear or nodular densities, a mass-like lesion, or thin-walled cavitary lesions. We present the case of pulmonary MAC in a patient with a history of lung cancer requiring lobectomy, and splenic lymphoma being treated with chemotherapy, presenting with extreme fatigue and a fludeoxyglucose (FDG)-avid mass on positron emission tomography-computed tomography (PET-CT)...
October 13, 2016: Curēus
https://www.readbyqxmd.com/read/27876856/the-trend-and-the-disease-prediction-of-vascular-endothelial-growth-factor-and-placenta-growth-factor-in-nontuberculous-mycobacterial-lung-disease
#10
Chou-Han Lin, Chin-Chung Shu, Chia-Lin Hsu, Shih-Lung Cheng, Jann-Yuan Wang, Chong-Jen Yu, Li-Na Lee
Nontuberculous mycobacteria (NTM)-lung disease (LD) is an increasing health problem worldwide. The diagnosis of this disease remains difficult, however the application of placenta growth factor (PlGF) and vascular endothelial growth factor (VEGF) has not yet been studied. We screened patients with Mycobacterium avium complex or M. abscessus isolated from sputum, and enrolled 32 patients with NTM-LD and 93 with NTM pulmonary colonization. The NTM-LD group had a lower body mass index, higher proportion of bronchiectasis, more respiratory symptoms and pulmonary lesions, and higher titers of sputum acid-fast stain than the NTM pulmonary colonization group...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27872066/clinical-characteristics-and-treatment-outcomes-of-patients-with-macrolide-resistant-mycobacterium-massiliense-lung-disease
#11
Hayoung Choi, Su-Young Kim, Hyun Lee, Byung Woo Jhun, Hye Yun Park, Kyeongman Jeon, Dae Hun Kim, Hee Jae Huh, Chang-Seok Ki, Nam Yong Lee, Seung-Heon Lee, Sung Jae Shin, Charles L Daley, Won-Jung Koh
Macrolide antibiotics are cornerstones in the treatment of Mycobacterium massiliense lung disease. Despite the emergence of resistance, limited data are available on macrolide-resistant M massiliense lung disease. This study evaluated the clinical features and treatment outcomes of patients and the molecular characteristics of macrolide-resistant M massiliense isolates. We performed a retrospective review of medical records and genetic analysis of clinical isolates from 15 patients with macrolide-resistant M massiliense lung disease between September 2005 and February 2015...
November 21, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27872065/in-vitro-susceptibility-testing-of-bedaquiline-against-mycobacterium-avium-complex
#12
Barbara A Brown-Elliott, Julie V Philley, David E Griffith, Foram Thakkar, Richard J Wallace
We performed bedaquiline broth microdilution susceptibilities using Clinical Laboratory Standards Institute (CLSI) guidelines on 103 respiratory isolates of Mycobacterium avium complex (MAC), including multidrug resistant isolates. Approximately 90% of isolates had bedaquiline minimal inhibitory concentrations (MICs) ≤0.008 μg/mL and 102/103 isolates had MICs ≤0.015 μg/mL. Bedaquiline has excellent potential for use in patients with MAC, although for reasons of its metabolism by the cytochrome P450 system, it should not be given with rifampin...
November 21, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27868301/exploring-maldi-tof-ms-approach-for-a-rapid-identification-of-mycobacterium-avium-subsp-paratuberculosis-field-isolates
#13
M Ricchi, A Mazzarelli, A Piscini, A Di Caro, A Cannas, S Leo, S Russo, N Arrigoni
AIMS: The aim of the study was to explore the suitability of MALDI-TOF MS for a rapid and correct identification of Mycobacterium avium subsp. paratuberculosis (MAP) field isolates. METHODS AND RESULTS: MALDI-TOF MS approach is becoming one of the most popular tests for the identification of intact bacterial cells which has been shown to be fast and reliable. For this purpose, 36 MAP field isolates were analysed through MALDI-TOF MS and the spectra compared with two different databases: one provided by the vendor of the system employed (Biotyper Version 3...
November 21, 2016: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/27851421/1786-mycobacterium-avium-complex-masquerading-as-non-small-cell-lung-cancer-recurrence
#14
Kelly Pennington, Alice Gallo De Moraes, Patricio Escalante
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27831800/macrolide-resistant-mycobacterium-avium-complex-i-feel-like-i-ve-been-here-before
#15
David E Griffith
No abstract text is available yet for this article.
November 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27826888/non-tuberculous-mycobacteria-classification-diagnostics-and-therapy
#16
I Porvaznik, I Solovič, J Mokrý
Non-tuberculous mycobacteria (NTM) are species other than those belonging to the Mycobacterium tuberculosis complex and do not cause leprosy. NTM are generally free-living organisms that are ubiquitous in the environment. There have been more than 140 NTM species identified to-date. They can cause a wide range of infections, with pulmonary infections being the most frequent (65-90 %). There is growing evidence that the incidence of NTM lung diseases and associated hospitalizations are on the rise, mainly in regions with a low prevalence of tuberculosis...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27823913/-cutaneous-lesions-during-hot-tub-hypersensitivity-pneumonitis-pseudomonas-folliculitis%C3%A2
#17
N Sokolowsky, L Rolland, M-A Vandenhende, J-Y Colin, F Laurent, P Morlat, F Bonnet, M Beylot-Barry
BACKGROUND: Interstitial lung disease, cutaneous rash and elevated serum angiotensin converting enzyme (ACE) may suggest diagnoses other than sarcoidosis. PATIENTS AND METHODS: A 58-year-old man had presented dyspnoea for 2 years with increased angiotensin-converting enzyme, as well as an interstitial syndrome and micronodules. The possibility of sarcoidosis was raised. Systemic corticosteroids resulted in improvement of the dyspnoea although it recurred on dose reduction...
November 4, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27818776/deciphering-the-virulence-factors-of-the-opportunistic-pathogen-mycobacterium-colombiense
#18
M N Gonzalez-Perez, M I Murcia, C Parra-Lopez, J Blom, A Tauch
Mycobacterium avium complex (MAC) contains clinically important nontuberculous mycobacteria worldwide and is the second largest medical complex in the Mycobacterium genus after the Mycobacterium tuberculosis complex. MAC comprises several species that are closely phylogenetically related but diverse regarding their host preference, course of disease, virulence and immune response. In this study we provided immunologic and virulence-related insights into the M. colombiense genome as a model of an opportunistic pathogen in the MAC...
November 2016: New Microbes and New Infections
https://www.readbyqxmd.com/read/27807554/mycobacterium-avium-intracellulare-complex-mac-producing-a-periportal-pseudotumor-in-a-patient-with-hiv-and-a-normal-cd4-count
#19
Jessica Johnson, Meghan Driscoll, Michael Cohen, Douglas G Adler
Mycobacterium avium-intracellulare complex (MAC) is an opportunistic infection typically associated with profound immunosuppression, such as AIDS. The presentation of disseminated MAC can be subtle and mimic systemic symptoms associated with lymphoma; abdominal pseudotumor is an exceptionally rare presentation. In the era of highly active anti-retroviral therapy (HAART), opportunistic infections are increasingly rare, and secondary prophylaxis for MAC may be discontinued after adequate therapy and immune reconstitution...
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/27790302/urinary-mycobacterium-avium-presenting-as-sterile-pyuria
#20
Kai Yang, Mary Samplaski, Tony Mazzulli, Kirk Lo, Ethan Grober, Keith Allen Jarvi
A 65-year-old healthy woman presented with persistent, asymptomatic sterile pyuria detected by her family physician. While she did not have symptoms, the patient recounts that she has had cloudy urine for years. Cultures of the urine for bacteria showed no growth and no fungi were identified. First-morning urine samples were sent for both tuberculosis and nontuberculosis mycobacterium species testing. The culture grew genotypically identified Mycobaterium avium complex (MAC). Mantoux skin testing was positive...
May 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
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