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Mycobacterium avium complex

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https://www.readbyqxmd.com/read/28793869/the-efficacy-safety-and-feasibility-of-inhaled-amikacin-for-the-treatment-of-difficult-to-treat-non-tuberculous-mycobacterial-lung-diseases
#1
Kazuma Yagi, Makoto Ishii, Ho Namkoong, Takahiro Asami, Osamu Iketani, Takanori Asakura, Shoji Suzuki, Hiroaki Sugiura, Yoshitake Yamada, Tomoyasu Nishimura, Hiroshi Fujiwara, Yohei Funatsu, Yoshifumi Uwamino, Tetsuro Kamo, Sadatomo Tasaka, Tomoko Betsuyaku, Naoki Hasegawa
BACKGROUND: In multidrug regimens, including an intravenous aminoglycoside (e.g. amikacin [AMK]) is recommended for difficult-to-treat non-tuberculous mycobacterial (NTM) lung diseases. We aimed to evaluate the efficacy, safety, and feasibility of inhaled AMK therapy in patients with difficult-to-treat NTM lung diseases in a retrospective chart review. METHODS: The study population consisted of patients with NTM lung diseases who received combination therapy, including inhaled AMK therapy, at Keio University Hospital (Tokyo, Japan), from January 2014 through May 2016...
August 9, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28791872/mycobacterium-avium-complex-infection-and-immune-reconstitution-inflammatory-syndrome-remain-a-challenge-in-the-era-of-effective-antiretroviral-therapy
#2
Olivia C Smibert, Jason Trubiano, Gail B Cross, Jennifer Hoy
A 10-year review of disseminated MAC infection and MAC-Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV-positive patients (2004-2014) at a state-wide tertiary referral HIV service, demonstrates that despite advances in antiretroviral therapy, MAC infection remains a therapeutic challenge, particularly intra-abdominal disease.
August 9, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28782649/comparison-of-methods-available-for-the-identification-of-mycobacterium-chimaera
#3
Emmanuel Lecorche, Sophie Haenn, Faiza Mougari, Sylvain Kumanski, Nicolas Veziris, Hanaa Benmansour, Laurent Raskine, Laurent Moulin, Emmanuelle Cambau
OBJECTIVES: Mycobacterium chimaera is a recently described nontuberculous mycobacterium belonging to the M. avium complex (MAC). Because this species is implicated in a worldwide outbreak due to contaminated heater-cooler unit water tanks during open-heart surgery, it becomes mandatory for clinical microbiology laboratories to be able to differentiate M. chimaera from the other MAC species, especially M. intracellulare. Such identification was so far restricted to specialized laboratories, since it required the analysis of several gene sequences...
August 4, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28756811/comparing-the-genotype-and-drug-susceptibilities-between-mycobacterium-avium-and-mycobacterium-intracellulare-in-china
#4
Hui Wen Zheng, Yu Pang, Guang Xue He, Yuan Yuan Song, Yan Lin Zhao
OBJECTIVE: Mycobacterium avium (M. avium) and Mycobacterium intracellulare (M. intracellulare) are the major causative agents of nontuberculous mycobacteria (NTM)-related pulmonary infections. However, little is known about the differences in drug susceptibility profiles between these two species. METHODS: A total of 393 NTM isolates were collected from Shanghai Pulmonary Disease Hospital. Sequencing of partial genes was performed to identify the strains at species level...
July 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28751677/nontuberculous-mycobacteria-in-denmark-incidence-and-clinical-importance-during-the-last-quarter-century
#5
Thomas S Hermansen, Pernille Ravn, Erik Svensson, Troels Lillebaek
Disease caused by nontuberculous mycobacteria (NTM) is reported to increase due to an ageing population and a rise in the proportion of immunosuppressed patients. We did a retrospective cohort study of NTM-disease in the Danish population through a quarter-century to determine the disease burden and trends in annual incidence rates. 524,119 clinical specimens were cultured for mycobacteria from 1991 through 2015 at the International Reference Laboratory of Mycobacteriology in Denmark. Among these, 8,227 NTM strains were identified from 3,462 patients and distributed according to microbiological disease criteria...
July 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28748197/incidence-long-term-outcomes-and-healthcare-utilization-of-patients-with-human-immunodeficiency-virus-acquired-immune-deficiency-syndrome-and-disseminated-mycobacterium-avium-complex-from-1992-2015
#6
Lauren F Collins, Meredith E Clement, Jason E Stout
BACKGROUND: Despite the advent of combination antiretroviral therapy (cART), patients with human immunodeficiency virus (HIV) continue to develop late-stage complications including acquired immune deficiency syndrome (AIDS), disseminated Mycobacterium avium complex (DMAC), and death. METHODS: We performed an observational retrospective cohort study of HIV-infected adults who developed DMAC in the Duke University Health System from 1992 to 2015 to determine the incidence, long-term outcomes, and healthcare utilization of this population at high risk for poor outcomes...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28721191/small-bowel-obstruction-due-to-mesenteric-abscess-caused-by-mycobacterium-avium-complex-in-an-hiv-patient-a-case-report-and-literature-review
#7
S M Mohar, Saqib Saeed, Alexius Ramcharan, Hector Depaz
Small bowel obstruction in HIV patients is reportedly caused by inflammatory pseudotumor, Kaposi's sarcoma, cryptococcal lymphadenopathy and intestinal tuberculosis. The incidence of Mycobacterium avium complex (MAC) infection in HIV patients is 3% for CD4 cell count of 100-199 /mm(3). MAC causing small bowel obstruction is rarely reported in the literature. We report a rare case of MAC causing mesenteric abscess with small bowel obstruction in a HIV patient with a CD4 cell count of 144 /mm(3). Patient was a 35-year-old HIV-positive male on highly active antiretroviral therapy who presented with partial small bowel obstruction secondary to mesenteric abscess...
July 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28713782/characterization-and-differentiation-of-mycobacterium-avium-subsp-paratuberculosis-from-other-mycobacteria-using-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry
#8
Subbarao V Ravva, Leslie A Harden, Chester Z Sarreal
Mycobacterium avium subsp. paratuberculosis (MAP), the causative agent of Johne's disease in cattle, is responsible for significant economic losses to the US dairy industry. The pathogen has also been associated with chronic human diseases like Crohn's disease, type 1 diabetes and multiple sclerosis. Determining causation requires rapid characterization and source tracking the pathogen. Here, we used matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry to characterize and differentiate strains of MAP from 14 other species of Mycobacterium from bovine, human, and environmental sources...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28708727/splenic-involvement-in-disseminated-mycobacterium-avium-intracellulare-infection-magnetic-resonance-imaging-findings
#9
Haley Clark, Gaurav Khatri, Payal Kapur, Ivan Pedrosa
We report the imaging findings of a patient with disseminated Mycobacterium avium-intracellulare complex presenting with multiple splenic lesions incompletely characterized on computed tomography in whom magnetic resonance imaging helped narrow the differential diagnosis. We discuss the magnetic resonance imaging findings suggesting the diagnosis, including the presence of focal susceptibility artifact within the lesions (ie, signal drop on T1 in-phase imaging), marked hypointensity on diffusion-weighted imaging, and faint progressive peripheral enhancement after contrast administration...
July 13, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28705770/in%C3%A2-vitro-activity-of-aminoglycosides-clofazimine-d-cycloserine-and-dapsone-against-83-mycobacterium-avium-complex-clinical-isolates
#10
Chen-Cheng Huang, Ming-Feng Wu, Hui-Chen Chen, Wei-Chang Huang
BACKGROUND/PURPOSE: Treatment success rates for Mycobacterium avium complex (MAC) diseases range from 50% to 55% only. To explore effective antimicrobials against either Mycobacteriumintracellulare or M. avium, we determined in vitro activities of five aminoglycosides, clofazimine, dapsone and d-cycloserine compared with primary (clarithromycin) and secondary (moxifloxacin and linezolid) antimycobacterial agents. METHODS: 83 non-duplicate clinical MAC isolates were collected from sputum and identified at the species level by PCR and restriction enzyme analysis of the 65 kDa hsp and rpoB genes...
June 28, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28702340/characteristics-of-mycobacterium-avium-complex-mac-pulmonary-disease-in-previously-treated-lung-cancer-patients
#11
Erin Meier, Kelly Pennington, Alice Gallo de Moraes, Patricio Escalante
INTRODUCTION: Mycobacterium avium complex (MAC) is responsible for a large portion of non-tuberculous mycobacterial (NTM) infections worldwide. Host factors such as active malignancy, immunosuppression, chronic obstructive pulmonary disease (COPD) and bronchiectasis increase the risk of MAC infection. However, the relationship between previously treated lung cancer with subsequent development of MAC pulmonary disease and treatment outcomes have not been previously studied. METHODS: We retrospectively identified all patients with lung cancer and MAC pulmonary disease documented in medical records at Mayo Clinic between January 2005 and October 2016...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28680616/a-case-of-bilateral-hilar-and-mediastinal-lymphadenopathy-developing-during-treatment-for-mycobacterium-avium-complex
#12
Yumie Yamanaka, Akimasa Sekine, Hideaki Yamakawa, Tomohisa Baba, Koji Okudela, Tamiko Takemura, Takashi Ogura
We report a rare case of an immunocompetent patient with Mycobacterium avium complex (MAC) disease in which bilateral hilar lymphadenopathy developed during anti-MAC treatment. This case indicates that Propionibacterium acnes would be present and might be a cause of sarcoidosis even in patients with MAC.
July 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28671535/comparative-analysis-of-the-genomes-of-clinical-isolates-of-mycobacterium-avium-subsp-hominissuis-regarding-virulence-related-genes
#13
COMPARATIVE STUDY
Brendan Jeffrey, Sasha J Rose, Kerrigan Gilbert, Matthew Lewis, Luiz E Bermudez
PURPOSE: Mycobacterium avium subsp. hominissuis is a member of the M. avium complex, a heterogeneous group of bacteria that cause lung infection in immunocompetent patients or disseminated infection in patients with immunosuppression. The bacteria belonging to this complex have variable virulence, depending on the strain considered, and therefore a representative of the most common clinical phenotype was analysed. METHODOLOGY: The genomic sequences of four M. avium subsp...
July 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28663777/disseminated-mycobacterium-avium-complex-in-an-adolescent-with-perinatally-acquired-hiv-infection
#14
Nurul I Hariadi, R Alexander Blackwood
Mycobacterium avium complex (MAC) is the most frequent nontuberculous mycobacteria implicated in opportunistic infections that define acquired immunodeficiency syndrome. With highly active antiretroviral therapy, disseminated MAC (dMAC) has become a rare entity. This unique case of dMAC was diagnosed in an adolescent with newly diagnosed perinatally-acquired HIV infection whose initial CD4 cell count was severely depleted and viral load was extremely high. While maximized treatment regimen had not been able to control his dMAC, improvement was noted when granulocyte macrophage colony-stimulating factor (GM-CSF) was added...
May 31, 2017: Infectious Disease Reports
https://www.readbyqxmd.com/read/28659320/development-of-a-one-step-multiplex-pcr-assay-for-differential-detection-of-major-mycobacterium-species
#15
Hansong Chae, Seung Jung Han, Su Young Kim, Chang-Seok Ki, Hee Jae Huh, Dongeun Yong, Won-Jung Koh, Sung Jae Shin
The prevalence of tuberculosis continues to be high, and nontuberculous mycobacteria (NTM) infection has also emerged worldwide. Moreover, differential and accurate identification of mycobacteria to the species or subspecies level is an unmet clinical need. Here, we developed a one-step multiplex PCR assay using whole-genome analysis and bioinformatics to identify novel molecular targets. The aims of this assay were to: 1) discriminate between the Mycobacterium tuberculosis complex (MTBC) and NTM using rv0577 or RD750; 2) differentiate M...
June 28, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28649235/detection-of-mycobacteria-by-culture-and-dna-based-methods-in-animal-derived-food-products-purchased-at-spanish-supermarkets
#16
Iker A Sevilla, Elena Molina, Maitane Tello, Natalia Elguezabal, Ramón A Juste, Joseba M Garrido
Mycobacteria include obligate and opportunistic pathogens that cause significant human and animal disease. The burden of tuberculosis has been largely reduced in developed territories but remains a huge problem worldwide. The significance of nontuberculous mycobacteria is growing considerably, especially in developed regions with higher life expectancy and more therapy-related immunosuppressed individuals. Due to their robustness mycobacteria can contaminate animal products by direct transmission from infected individuals or by environmental contamination during processing...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28629426/development-and-validation-of-a-prognostic-scoring-model-for-mycobacterium-avium-complex-lung-disease-an-observational-cohort-study
#17
Shogo Kumagai, Akihiro Ito, Toru Hashimoto, Satoshi Marumo, Hironobu Tokumasu, Aya Kotani, Haruka Yamaki, Masahiro Shirata, Koji Furuuchi, Motonari Fukui, Tadashi Ishida
BACKGROUND: Patients with Mycobacterium avium complex (MAC) lung disease (LD) have a heterogeneous prognosis. This study aimed to develop and validate a prognostic scoring model for these patients using independent risk factors for survival. METHODS: We retrospectively analyzed the data of patients with MAC-LD from two hospitals (cohort 1, n = 368; cohort 2, n = 118). Cohort 1 was evaluated using a multivariate Cox proportional hazards model to identify independent risk factors for overall survival (OS)...
June 19, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28619015/nontuberculosis-mycobacterial-infections-at-a-specialized-tuberculosis-treatment-centre-in-the-republic-of-korea
#18
Hee Jung Yoon, Hwa Young Choi, Moran Ki
BACKGROUND: The incidence of nontuberculous mycobacteria (NTM) infections is increasing worldwide, however formal evaluations of the epidemiology of NTM infections are limited. Understanding the trends and true prevalence of NTM is a major priority for optimizing infection control programmes and resources. The purpose of this study was to investigate the epidemiology, clinical manifestations, and radiologic findings in NTM-infected patients at specialized Tuberculosis (Tb) treatment centre in South Korea, which is endemic to Tb, and find solutions to control NTM infections...
June 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28606745/the-characteristics-of-patients-with-pulmonary-mycobacterium-avium-intracellulare-complex-disease-diagnosed-by-bronchial-lavage-culture-compared-to-those-diagnosed-by-sputum-culture
#19
Koichi Maekawa, Megumi Naka, Saki Shuto, Yuka Harada, Yumiko Ikegami
BACKGROUND AND OBJECTIVE: The utility of bronchoscopy for the diagnosis of pulmonary Mycobacterium avium-intracellulare complex (MAC) disease has been reported; however, which patients require bronchoscopy remains unclear. Our objective was to identify the characteristics of the patients in whom bronchoscopy is needed for the diagnosis of MAC disease. METHODS: Fifty-four patients with pulmonary MAC disease were divided into two groups according to established diagnostic criteria: 39 patients were diagnosed by sputum culture and 15 patients were diagnosed by bronchial lavage culture...
September 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28600772/a-closed-tube-loop-mediated-isothermal-amplification-assay-for-the-visual-endpoint-detection-of-brucella-spp-and-mycobacterium-avium-subsp-paratuberculosis
#20
Marcos D Trangoni, Andrea K Gioffré, Silvio L Cravero
LAMP (loop-mediated isothermal amplification) is an isothermal nucleic acid amplification technique that is characterized by its efficiency, rapidity, high yield of final product, robustness, sensitivity, and specificity, with the blueprint that it can be implemented in laboratories of low technological complexity. Despite the conceptual complexity underlying the mechanistic basis for the nucleic acid amplification, the technique is simple to use and the amplification and detection can be carried out in just one step...
2017: Methods in Molecular Biology
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