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Whipple disease

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https://www.readbyqxmd.com/read/28936074/syndromes-of-rapidly-progressive-cognitive-decline-our-experience
#1
Sadanandavalli Retnaswami Chandra, Lakshminarayanapuram Gopal Viswanathan, Anupama Ramakanth Pai, Rahul Wahatule, Suvarna Alladi
BACKGROUND: Dementias are fairly slowly progressive degenerative diseases of brain for which treatment options are very less and carry a lot of burden on family and society. A small percentage of them are rapidly progressive and mostly carry a different course outcome. However, there are no definite criteria other than the time line for these patients. AIMS: The aim of this was to identify and categorize the causes and course of rapidly progressive dementias seen in our center...
August 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28895032/resection-of-locally-advanced-pancreatic-cancer-without-regression-of-arterial-encasement-after-modern-era-neoadjuvant-therapy
#2
Michael D Kluger, M Farzan Rashid, Vilma L Rosario, Beth A Schrope, Jonathan A Steinman, Elizabeth M Hecht, John A Chabot
INTRODUCTION: Modern-era systemic therapy for locally advanced pancreatic adenocarcinoma (LAPC) offers improved survival relative to historical regimens but not necessarily improved radiographic downstaging to allow more patients to undergo resection. The aim of this study was to evaluate the survival, progression, and pathologic outcomes after resection of LAPC that did not regress from > 180 degrees arterial encasement after neoadjuvant therapy. METHODS: Sixty-one LAPC patients were brought to the operating room after neoadjuvant therapy for NCCN-defined unresectable pancreatic cancer between 2012 and 2017...
September 11, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28876641/gene-and-protein-expression-profiling-of-pdac-tumours-obtained-from-black-south-african-patients-reveal-novel-potential-biomarkers
#3
E N Nweke, M N Ntwasa, M B Brand, J D Devar, M D Smith, G P Candy
BACKGROUND: Pancreatic cancer (PDAC) is a devastating cancer. It accounts for about 7% of cancer related deaths worldwide. During PDAC, several genes are altered. These alterations consequently lead to the progression of PDAC. Analysis of these alterations in the context of signalling pathways help in understanding the disease. METHOD: 18 Tissue (9 tumour, 9 normal) samples were obtained from Black South African stage I PDAC patients during the Whipple procedure...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28876640/gene-and-protein-expression-profiling-of-pancreatic-tumours-reveal-dysregulated-pathways-and-novel-potential-biomarker
#4
E N Nweke, M N Ntwasa, M B Brand, J D Devar, M D Smith, G P Candy
BACKGROUND: Pancreatic cancer (PDAC) is a deadly type of cancer with almost an equal amount of new cases and deaths observed yearly. It accounts for about 7% of cancer-related deaths worldwide. In many multi-racial societies including South Africa, the black population has the highest incidence rate. Less than 5% of PDAC patients live up to 5 years. The lack of specific and sensitive diagnostic PDAC biomarkers is strongly responsible for this poor statistic. The discovery of differentially expressed genes and proteins associated with PDAC is crucial to elucidating this condition and may lead to biomarker finding and further understanding of the disease...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28811947/solitary-skull-metastasis-as-the-first-presentation-of-a-metachronous-primary-lung-cancer-in-a-survivor-from-pancreatic-cancer
#5
Ali Altalhy, Yazid Maghrabi, Zuhoor Almansouri, Saleh S Baeesa
Skull metastasis from lung cancer is relatively common, yet the first presentation for this malignant disease is a rare occurrence. We herein report a case of a 54-year-old female, who had a good outcome following Whipple procedure for periampullary adenocarcinoma five years before her current presentation. During a routine follow-up, she was found to have a slowly progressive painless right parietal swelling. The systemic screening workup revealed no abdominal disease, but a solitary pulmonary nodule was identified...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/28770535/cytology-of-cerebrospinal-fluid-in-cns-whipple-disease
#6
Marina Boban, Koraljka Gjadrov-Kuveždić, Jasminka Jakić-Razumović
No abstract text is available yet for this article.
August 2, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28761367/protein-losing-enteropathy-comprehensive-review-of-the-mechanistic-association-with-clinical-and-subclinical-disease-states
#7
REVIEW
David G Levitt, Michael D Levitt
Protein losing enteropathy (PLE) has been associated with more than 60 different conditions, including nearly all gastrointestinal diseases (Crohn's disease, celiac, Whipple's, intestinal infections, and so on) and a large number of non-gut conditions (cardiac and liver disease, lupus, sarcoidosis, and so on). This review presents the first attempt to quantitatively understand the magnitude of the PLE in relation to the associated pathology for three different disease categories: 1) increased lymphatic pressure (e...
2017: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/28757865/emergency-backwards-whipple-for-bleeding-formidable-and-definitive-surgery
#8
Cristian Lupascu, Ana Trofin, Mihai Zabara, Alexandra Vornicu, Ramona Cadar, Nutu Vlad, Oana Apopei, Valentin Grigorean, Corina Lupascu-Ursulescu
INTRODUCTION: During the past decades, the safety of pancreatoduodenectomy has improved, with low mortality and reduced morbidity, particularly in centers with extensive experience. Emergency pancreatoduodenectomy is an uncommon event, for treatment of pancreaticoduodenal trauma, bleeding, or perforation. We herein present a single center experience concerning nontrauma emergency pancreatoduodenectomy for pancreaticoduodenal bleeding. METHODS: From January 2007 to December 2015, from a population of 134 PD (70 males and 64 females, mean age 62...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28744253/novel-eye-movement-disorders-in-whipple-s-disease-staircase-horizontal-saccades-gaze-evoked-nystagmus-and-esotropia
#9
Aasef G Shaikh, Fatema F Ghasia
Whipple's disease, a rare systemic infectious disorder, is complicated by the involvement of the central nervous system in about 5% of cases. Oscillations of the eyes and the jaw, called oculo-masticatory myorhythmia, are pathognomonic of the central nervous system involvement but are often absent. Typical manifestations of the central nervous system Whipple's disease are cognitive impairment, parkinsonism mimicking progressive supranuclear palsy with vertical saccade slowing, and up-gaze range limitation. We describe a unique patient with the central nervous system Whipple's disease who had typical features, including parkinsonism, cognitive impairment, and up-gaze limitation; but also had diplopia, esotropia with mild horizontal (abduction more than adduction) limitation, and vertigo...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28724483/using-white-tailed-deer-odocoileus-virginianus-in-infectious-disease-research
#10
Mitchell V Palmer, Rebecca J Cox, W Ray Waters, Tyler C Thacker, Diana L Whipple
Between 1940 and 2004, more than 335 emerging infectious disease events were reported in the scientific literature. The majority (60%) of these events involved zoonoses, most of which (72%) were of wildlife origin or had an epidemiologically important wildlife host. Because this trend of increasing emerging diseases likely will continue, understanding the pathogenesis, transmission, and diagnosis of these diseases in the relevant wildlife host is paramount. Achieving this goal often requires using wild animals as research subjects, which are vastly different from the traditional livestock or laboratory animals used by most universities and institutions...
July 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28691008/fluorescence-in-situ-hybridization-for-diagnosis-of-whipple-s-disease-in-formalin-fixed-paraffin-embedded-tissue
#11
Peter Braubach, Torsten Lippmann, Didier Raoult, Jean-Christophe Lagier, Ioannis Anagnostopoulos, Steffen Zender, Florian Peter Länger, Hans-Heinrich Kreipe, Mark Philipp Kühnel, Danny Jonigk
Whipple's disease (WD) is a rare chronic systemic infection with a wide range of clinical symptoms, routinely diagnosed in biopsies from the small intestine and other tissues by periodic acid-Schiff (PAS) diastase staining and immunohistological analysis with specific antibodies. The aim of our study was to improve the pathological diagnosis of WD. Therefore, we analyzed the potential of fluorescence in situ hybridization (FISH) for diagnosing WD, using a Tropheryma (T.) whipplei-specific probe. 19 formalin-fixed paraffin-embedded (FFPE) duodenal biopsy specimens of 12 patients with treated (6/12) and untreated (6/12) WD were retrospectively examined using PAS diastase staining, immunohistochemistry, and FISH...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28660130/mesenteric-lymphadenitis-as-a-presenting-feature-of-whipple-s-disease
#12
Mwelwa Chizinga, Danise Schiliro, Brett Mullin, Rashida La Barrie
Detecting Whipple's disease, a "great imitator", requires a high index of suspicion so that antimicrobial treatment can be initiated in a timely manner; a missed diagnosis can be fatal. Although an uncommon cause, Whipple's disease must be considered in adults with mesenteric lymphadenitis. We report the case of a 39-year-old African American man who presented with chronic joint pain, chronic weight loss, and acute onset epigastric pain. Contrast-enhanced computed tomography of the abdomen and pelvis showed extensive mesenteric lymphadenopathy...
2017: IDCases
https://www.readbyqxmd.com/read/28652415/solid-pseudopapillary-tumor-of-the-pancreas-a-single-center-experience-and-review-of-the-literature
#13
REVIEW
Efstathios A Antoniou, Christos Damaskos, Nikolaos Garmpis, Christos Salakos, Giorgos-Antonios Margonis, Konstantinos Kontzoglou, Stefanos Lahanis, Eleftherios Spartalis, Dimitrios Patsouras, Stylianos Kykalos, Anna Garmpi, Nikolaos Andreatos, Timothy M Pawlik, Gregory Kouraklis
BACKGROUND: Solid pseudopapillary tumors (SPTs) of the pancreas are a rare occurrence, not exceeding 1-2% of all exocrine pancreatic tumors. SPT was first described in 1959 as "papillary tumor of the pancreas, benign or malignant" and affects mainly young women, in their second or third decade of age. These tumors are of low malignant potential, unclear pathogenesis, grow gradually and become considerably large before causing symptoms. A typical clinical presentation is often described by affected patients and, in some cases, an SPT is an incidental finding during the time the patient undergoes medical imaging studies for other health issues...
July 2017: In Vivo
https://www.readbyqxmd.com/read/28633596/laparotomy-site-implantation-metastasis-of-carcinoma-of-the-papilla-of-vater
#14
Milan Radojkovic, Jasmina Gligorijevic, Miroslav Stojanovic, Goran Stanojevic, Ivan Ilic
Introduction Carcinomas of the papilla of Vater make up a heterogeneous group of tumours arising from different types of epithelium. Regional lymph nodes, liver and lungs are the primary sites of metastatic progression of these tumours. Case presentation We present a patient with an abdominal incision site metastasis of low-grade (mixed type) adenocarcinoma of the papilla of Vater one year after pylorus-preserving pancreaticoduodenectomy. Implantation metastasis of low-grade ampullary carcinoma in the laparotomy wound after open Whipple's procedure is unusual...
January 1, 2017: Scottish Medical Journal
https://www.readbyqxmd.com/read/28622620/simultaneous-uhplc-uv-analysis-of-hydroxychloroquine-minocycline-and-doxycycline-from-serum-samples-for-the-therapeutic-drug-monitoring-of-q-fever-and-whipple-s-disease
#15
Nicholas Armstrong, Magali Richez, Didier Raoult, Eric Chabriere
A fast UHPLC-UV method was developed for the simultaneous analysis of Hydroxychloroquine, Minocycline and Doxycycline drugs from 100μL of human serum samples. Serum samples were extracted by liquid-liquid extraction and injected into a phenyl hexyl reverse phase column. Compounds were separated using a mobile phase linear gradient and monitored by UV detection at 343nm. Chloroquine and Oxytetracycline were used as internal standards. Lower and upper limits of quantifications, as well as the other levels of calibration, were validated with acceptable accuracy (<15% deviation) and precision (<15% coefficient of variation) according to the European Medicines Agency guidelines...
August 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28614004/anthropometric-features-are-not-predictive-of-72-hour-fast-duration-in-insulinomas
#16
Diane Donegan, Iva Jakubikova, Adrian Vella
OBJECTIVE: The 72-hour fast is used to document Whipple's triad and understand the mechanism of hypoglycemia. Although hypoglycemia develops within 24 hours in the majority of fasts, identifying possible determinants of fast duration may help to predict the need for admission. Therefore, we determined the relation between anthropometric features on fast duration and assessed end of fast parameters on maximal tumor size, extent of disease, or tumor recurrence. METHODS: A retrospective analysis of patients with insulinoma in the past 25 years who underwent a 72-hour fast was conducted...
August 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28570327/gastroenterology-and-neurology
#17
Ronald F Pfeiffer
PURPOSE OF REVIEW: Just as gastrointestinal dysfunction may develop in the setting of neurologic disease, neurologic dysfunction may become evident in the setting of gastrointestinal disease. This article describes the range of neurologic features that have been described in three primary gastrointestinal diseases: celiac disease and gluten-related disorders, inflammatory bowel disease, and Whipple disease. Particular emphasis is placed on the controversial and evolving clinical picture of neurologic dysfunction in disorders of gluten sensitivity...
June 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28559404/peripheral-t-cell-reactivity-to-heat-shock-protein-70-and-its-cofactor-grpe-from-tropheryma-whipplei-is-reduced-in-patients-with-classical-whipple-s-disease
#18
Lucia Trotta, Kathleen Weigt, Katina Schinnerling, Anika Geelhaar-Karsch, Gerrit Oelkers, Federico Biagi, Gino Roberto Corazza, Kristina Allers, Thomas Schneider, Ulrike Erben, Verena Moos
Classical Whipple's disease (CWD) is characterized by the lack of specific Th1 response toward Tropheryma whipplei in genetically predisposed individuals. The cofactor GrpE of heat shock protein 70 (Hsp70) from T. whipplei was previously identified as a B-cell antigen. We tested the capacity of Hsp70 and GrpE to elicit specific proinflammatory T-cell responses. Peripheral mononuclear cells from CWD patients and healthy donors were stimulated with T. whipplei lysate or recombinant GrpE or Hsp70 before levels of CD40L, CD69, perforin, granzyme B, CD107a, and gamma interferon (IFN-γ) were determined in T cells by flow cytometry...
August 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28545554/whipple-s-disease-mimicking-rheumatoid-arthritis-can-cause-misdiagnosis-and-treatment-failure
#19
Cornelia Glaser, Siegbert Rieg, Thorsten Wiech, Christine Scholz, Dominique Endres, Oliver Stich, Peter Hasselblatt, Walter Geißdörfer, Christian Bogdan, Annerose Serr, Georg Häcker, Reinhard E Voll, Jens Thiel, Nils Venhoff
BACKGROUND: Whipple's disease, a rare chronic infectious disorder caused by Tropheryma whipplei, may present with predominant joint manifestations mimicking rheumatoid arthritis (RA). METHODS: A retrospective single-center cohort study of seven patients was performed. Clinical symptoms were assessed by review of medical charts and Whipple's disease was diagnosed by periodic-acid-Schiff-stain and/or Tropheryma whipplei-specific polymerase-chain-reaction. RESULTS: Median age at disease onset was 54 years, six patients were male...
May 25, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28502319/an-unusual-case-of-a-young-patient-with-whipple-s-disease-involving-the-central-nervous-system
#20
Margaret E Flanagan, Nicole Andeen, Joshua Lieberman, Joseph Freeburg, John R Williams, Daniel R Hoogestraat, Andrew Bryan, Daniel E Sabath
No abstract text is available yet for this article.
May 15, 2017: Clinical Neuropathology
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