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REVIEW
Paul G Mastrokostas, Leonidas E Mastrokostas, Ahmed K Emara, Ian J Wellington, Elizabeth Ginalis, John K Houten, Amrit S Khalsa, Ahmed Saleh, Afshin E Razi, Mitchell K Ng
STUDY DESIGN: Comparative study. OBJECTIVES: This study aims to compare Google and GPT-4 in terms of (1) question types, (2) response readability, (3) source quality, and (4) numerical response accuracy for the top 10 most frequently asked questions (FAQs) about anterior cervical discectomy and fusion (ACDF). METHODS: "Anterior cervical discectomy and fusion" was searched on Google and GPT-4 on December 18, 2023. Top 10 FAQs were classified according to the Rothwell system...
March 21, 2024: Global Spine Journal
#22
JOURNAL ARTICLE
Eimo Martens, Hans-Ulrich Haase, Giulio Mastella, Andreas Henkel, Christoph Spinner, Franziska Hahn, Congyu Zou, Augusto Fava Sanches, Julia Allescher, Daniel Heid, Elena Strauss, Melanie-Maria Maier, Mark Lachmann, Georg Schmidt, Dominik Westphal, Tobias Haufe, David Federle, Daniel Rueckert, Martin Boeker, Matthias Becker, Karl-Ludwig Laugwitz, Alexander Steger, Alexander Müller
INTRODUCTION: Today, modern technology is used to diagnose and treat cardiovascular disease. These medical devices provide exact measures and raw data such as imaging data or biosignals. So far, the Broad Integration of These Health Data into Hospital Information Technology Structures-Especially in Germany-is Lacking, and if data integration takes place, only non-Evaluable Findings are Usually Integrated into the Hospital Information Technology Structures. A Comprehensive Integration of raw Data and Structured Medical Information has not yet Been Established...
2024: Frontiers in digital health
#23
JOURNAL ARTICLE
Despoina Petsani, Teemu Santonen, Beatriz Merino-Barbancho, Gorka Epelde, Panagiotis Bamidis, Evdokimos Konstantinidis
BACKGROUND: Health and Wellbeing Living Labs are a valuable research infrastructure for exploring innovative solutions to tackle complex healthcare challenges and promote overall wellbeing. A knowledge gap exists in categorizing and understanding the types of ICT tools and technical devices employed by Living Labs. AIM: Define a comprehensive taxonomy that effectively categorizes and organizes the digital data collection and intervention tools employed in Health and Wellbeing Living Lab research studies...
March 10, 2024: International Journal of Medical Informatics
#24
JOURNAL ARTICLE
Kristoff Misquitta, Bess M Miller, Kathryn Malecek, Emily Gleason, Kathryn Martin, Chad M Walesky, Kevin Foley, D Scott Copeland, Ezequiel Alvarez Saavedra, Sebastian Kraves
Fluorescence-based assays provide sensitive and adaptable methods for point of care testing, environmental monitoring, studies of protein abundance and activity, and a wide variety of additional applications. Currently, their utility in remote and low-resource environments is limited by the need for technically complicated or expensive instruments to read out fluorescence signal. Here we describe the Genes in Space Fluorescence Viewer (GiS Viewer), a portable, durable viewer for rapid molecular assay readout that can be used to visualize fluorescence in the red and green ranges...
2024: PloS One
#25
JOURNAL ARTICLE
James J Butler, James Puleo, Michael C Harrington, Jari Dahmen, Andrew J Rosenbaum, Gino M M J Kerkhoffs, John G Kennedy
PURPOSE: The purpose of this study was to evaluate the effectiveness of an Artificial Intelligence-Large Language Model (AI-LLM) at improving the readability of knee radiology reports. METHODS: Reports of 100 knee X-rays, 100 knee computed tomography (CT) scans and 100 knee magnetic resonance imaging (MRI) scans were retrieved. The following prompt command was inserted into the AI-LLM: 'Explain this radiology report to a patient in layman's terms in the second person:[Report Text]'...
March 15, 2024: Knee Surgery, Sports Traumatology, Arthroscopy
#26
JOURNAL ARTICLE
Monica J Holmes, Babak Mahjour, Christopher P Castro, Gregory A Farnum, Adam G Diehl, Alan P Boyle
Understanding the functional effects of sequence variation is crucial in genomics. Individual human genomes contain millions of variants that contribute to phenotypic variability and disease risks at the population level. Because variants rarely act in isolation, we must consider potential interactions of neighboring variants to accurately predict functional effects. We can accomplish this using haplotagging, which matches sequencing reads to their parental haplotypes using alleles observed at known heterozygous variants...
2024: PloS One
#27
JOURNAL ARTICLE
Xiaochen Yu, Jinghui Yu, Sizhang Liu, Mingming Liu, Kangyu Wang, Mingzhu Zhao, Yanfang Wang, Ping Chen, Jun Lei, Yi Wang, Meiping Zhang
Panax ginseng as a traditional medicinal plant with a long history of medicinal use. Ginsenoside Ro is the only oleanane-type ginsenoside in ginseng, and has various pharmacological activities, including anti-inflammatory, detoxification, and antithrombotic activities. UDP-dependent glycosyltransferase (UGT) plays a key role in the synthesis of ginsenoside, and the excavation of UGT genes involved in the biosynthesis of ginsenoside Ro has great significance in enriching ginsenoside genetic resources and further revealing the synthesis mechanism of ginsenoside...
February 23, 2024: Plants (Basel, Switzerland)
#28
JOURNAL ARTICLE
Jonah Zaretsky, Jeong Min Kim, Samuel Baskharoun, Yunan Zhao, Jonathan Austrian, Yindalon Aphinyanaphongs, Ravi Gupta, Saul B Blecker, Jonah Feldman
IMPORTANCE: By law, patients have immediate access to discharge notes in their medical records. Technical language and abbreviations make notes difficult to read and understand for a typical patient. Large language models (LLMs [eg, GPT-4]) have the potential to transform these notes into patient-friendly language and format. OBJECTIVE: To determine whether an LLM can transform discharge summaries into a format that is more readable and understandable. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study evaluated a sample of the discharge summaries of adult patients discharged from the General Internal Medicine service at NYU (New York University) Langone Health from June 1 to 30, 2023...
March 4, 2024: JAMA Network Open
#29
Zahra Zare Jousheghani, Rob Patro
MOTIVATION: Long read sequencing technology is becoming an increasingly indispensable tool in genomic and transcriptomic analysis. In transcriptomics in particular, long reads offer the possibility of sequencing full-length isoforms, which can vastly simplify the identification of novel transcripts and transcript quantification. However, despite this promise, the focus of much long read method development to date has been on transcript identification, with comparatively little attention paid to quantification...
March 1, 2024: bioRxiv
#30
JOURNAL ARTICLE
Paicheng Liu, Jianxin Cheng, Yuxuan Yang, Haipeng Zhu
BACKGROUND: Orthopaedics have become the focus of research on patient safety due to the high incidence of medical errors. Previous studies were based on all orthopaedic patients and rarely conducted empirical analyses from the perspective of age. This study aimed to fill the academic gap in the age variable by comparing medical errors, affected sites, and adverse consequences in orthopaedic patients. METHODS: This retrospective study included 329 litigation claims against orthopaedists using data from China Judgments Online...
2024: Frontiers in Public Health
#31
REVIEW
Gangqiang Yu, Chengna Dai, Ning Liu, Ruinian Xu, Ning Wang, Biaohua Chen
Separation and reaction processes are key components employed in the modern chemical industry, and the former accounts for the majority of the energy consumption therein. In particular, hydrocarbon separation and purification processes, such as aromatics extraction, desulfurization, and denitrification, are challenging in petroleum refinement, an industrial cornerstone that provides raw materials for products used in human activities. The major technical shortcomings in solvent extraction are volatile solvent loss, product entrainment leading to secondary pollution, low separation efficiency, and high regeneration energy consumption due to the use of traditional organic solvents with high boiling points as extraction agents...
March 6, 2024: Chemical Reviews
#32
JOURNAL ARTICLE
Luciano Veiga Cosme, Margaret Corley, Thomas Johnson, Dave W Severson, Guiyun Yan, Xiaoming Wang, Nigel Beebe, Andrew Maynard, Mariangela Bonizzoni, Ayda Khorramnejad, Ademir Jesus Martins, José Bento Pereira Lima, Leonard E Munstermann, Sinnathamby N Surendran, Chun-Hong Chen, Kevin Maringer, Isra Wahid, Shomen Mukherjee, Jiannon Xu, Michael C Fontaine, Elizabet L Estallo, Marina Stein, Todd Livdahl, Patricia Y Scaraffia, Brendan H Carter, Motoyoshi Mogi, Nobuko Tuno, James W Mains, Kim A Medley, David E Bowles, Richard J Gill, Roger Eritja, Ranulfo González-Obando, Huynh T T Trang, Sébastien Boyer, Ann-Marie Abunyewa, Kayleigh Hackett, Tina Wu, Justin Nguyễn, Jiangnan Shen, Hongyu Zhao, Jacob E Crawford, Peter Armbruster, Adalgisa Caccone
BACKGROUND: Although whole-genome sequencing (WGS) is the preferred genotyping method for most genomic analyses, limitations are often experienced when studying genomes characterized by a high percentage of repetitive elements, high linkage, and recombination deserts. The Asian tiger mosquito (Aedes albopictus), for example, has a genome comprising up to 72% repetitive elements, and therefore we set out to develop a single-nucleotide polymorphism (SNP) chip to be more cost-effective. Aedes albopictus is an invasive species originating from Southeast Asia that has recently spread around the world and is a vector for many human diseases...
March 4, 2024: Parasites & Vectors
#33
JOURNAL ARTICLE
Ignacio Rosas-Román, Héctor Guillén-Alonso, Abigail Moreno-Pedraza, Robert Winkler
Julia combines the virtues of high-level and low-level programming languages: The code is human-readable, and the performance of the created binaries competes with machine-orientated compilers. Thus, Julia is popular in "Big Data" sciences. Reading mass spectrometry (MS) data with Julia was impossible until now due to missing libraries. Here, we present a Julia library for importing mass spectrometry (MS) data in HUPO standard mzML and imzML formats and demonstrate its function with direct and ambient ionization MS, liquid chromatography-MS, and MS imaging data on standard platforms (Windows, Linux, and Mac OS)...
March 1, 2024: Analytical Chemistry
#34
Akshay Khunte, Veer Sangha, Evangelos K Oikonomou, Lovedeep Singh Dhingra, Arya Aminorroaya, Andreas Coppi, Sumukh Vasisht Shankar, Bobak J Mortazavi, Deepak L Bhatt, Harlan M Krumholz, Girish Nadkarni, Akhil Vaid, Rohan Khera
Timely and accurate assessment of electrocardiograms (ECGs) is crucial for diagnosing, triaging, and clinically managing patients. Current workflows rely on a computerized ECG interpretation using rule-based tools built into the ECG signal acquisition systems with limited accuracy and flexibility. In low-resource settings, specialists must review every single ECG for such decisions, as these computerized interpretations are not available. Additionally, high-quality interpretations are even more essential in such low-resource settings as there is a higher burden of accuracy for automated reads when access to experts is limited...
February 18, 2024: medRxiv
#35
REVIEW
Ilaha Isali, Emma K Helstrom, Nicole Uzzo, Ankita Lakshmanan, Devika Nandwana, Henkel Valentine, Mohit Sindhani, Philip Abbosh, Laura Bukavina
PURPOSE OF THE REVIEW: Microbiome research has provided valuable insights into the associations between microbial communities and bladder cancer. However, this field faces significant challenges that hinder the interpretation, generalization, and translation of findings into clinical practice. This review aims to elucidate these challenges and highlight the importance of addressing them for the advancement of microbiome research in bladder cancer. RECENT FINDINGS: Recent findings underscore the complexities involved in microbiome research, particularly in the context of bladder cancer...
March 2024: Current Oncology Reports
#36
JOURNAL ARTICLE
Mark R Viant, E Amstalden, T Athersuch, M Bouhifd, S Camuzeaux, D M Crizer, P Driemert, T Ebbels, D Ekman, B Flick, V Giri, M Gómez-Romero, V Haake, M Herold, A Kende, F Lai, P E G Leonards, P P Lim, G R Lloyd, J Mosley, C Namini, J R Rice, S Romano, C Sands, M J Smith, T Sobanski, A D Southam, L Swindale, B van Ravenzwaay, T Walk, R J M Weber, F M Zickgraf, H Kamp
While grouping/read-across is widely used to fill data gaps, chemical registration dossiers are often rejected due to weak category justifications based on structural similarity only. Metabolomics provides a route to robust chemical categories via evidence of shared molecular effects across source and target substances. To gain international acceptance, this approach must demonstrate high reliability, and best-practice guidance is required. The MetAbolomics ring Trial for CHemical groupING (MATCHING), comprising six industrial, government and academic ring-trial partners, evaluated inter-laboratory reproducibility and worked towards best-practice...
February 18, 2024: Archives of Toxicology
#37
JOURNAL ARTICLE
Conor Costigan, Caroline Walker, Jim O'Connell, Emmanuel Omallao, Thilagaraj Manoharan, Niamh Eagle, Yvonne Bailey, Fintan O'Hara, Deirdre Mc Namara
Background and study aims Telemedicine has progressed significantly in recent years, with newer, more integrated information technology systems improving healthcare delivery. The development of the world's first cloud-based capsule platform could allow safe and timely virtual analysis of videos from a network of linked hospital centers. We aimed to assess the efficacy of Medtronic's PillCam Remote Reader System. Methods PillCam remote reader technical data were collected from the capsule endoscopy (CE) database over 8 months...
February 2024: Endoscopy International Open
#38
JOURNAL ARTICLE
Wenhui Zeng, Danni Shen, Wenjing Wu, Shijun Zhang, Zhiqiang Li, Dandan Zhang
BACKGROUND: Detoxifying enzymes are likely involved in lignin feeding and immune defense mechanisms within termites, rendering them potential targets for biological control. However, investigations into the dual functionality of termite detoxification enzymes in vivo have not been documented. RESULTS: In this study, the complete cDNA of the catalase gene (Cfcat) derived from Coptotermes formosanus Shiraki was amplified. CFCAT comprises an open reading frame spanning 1527 bp, encoding a 508-amino acid sequence...
February 15, 2024: Pest Management Science
#39
JOURNAL ARTICLE
Sudhakar Takkellapati, Michael A Gonzalez
The read-across method is a popular data gap filling technique with developed application for multiple purposes, including regulatory. Within the US Environmental Protection Agency's (US EPA) New Chemicals Program under Toxic Substances Control Act (TSCA), read-across has been widely used, as well as within technical guidance published by the Organization for Economic Co-operation and Development, the European Chemicals Agency, and the European Center for Ecotoxicology and Toxicology of Chemicals for filling chemical toxicity data gaps...
December 28, 2023: Clean Technol Recycl
#40
JOURNAL ARTICLE
Enrico Berrino, Sara Erika Bellomo, Anita Chesta, Paolo Detillo, Alberto Bragoni, Amedeo Gagliardi, Alessio Naccarati, Matteo Cereda, Gianluca Witel, Anna Sapino, Benedetta Bussolati, Gianni Bussolati, Caterina Marchiò
Formalin-fixed paraffin-embedded (FFPE) samples represent the cornerstone of tissue-based analysis in precision medicine. Targeted next-generation sequencing panels are routinely used to analyze a limited number of genes to guide treatment decision-making for advanced-stage patients. The number and complexity of genetic alterations to be investigated are rapidly growing; in several instances, a comprehensive genomic profiling analysis is needed. The poor quality of genetic material extracted from FFPE samples may impact the feasibility/reliability of sequencing data...
January 2024: Laboratory Investigation; a Journal of Technical Methods and Pathology
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