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https://www.readbyqxmd.com/read/28633460/guidelines-for-composing-and-assessing-a-paper-on-treatment-of-pain
#1
Nikolai Bogduk, David J Kennedy, Yakov Vorobeychik, Andrew Engel
Authors, readers, and editors share a common focus. Authors want to publish their work. Readers want to see high-quality, new information. Referees and editors serve to ensure that authors provide valid conclusions based on the quality of information that readers want. Common to each of these roles are instructions to authors. However, these are typically written in an uninspiring, legalistic style, as if they are a set of rules that authors must obey if they expect to get published. This renders the instructions boring and oppressive, if not forbidding...
June 17, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28622351/dna-extraction-replicates-improve-diversity-and-compositional-dissimilarity-in-metabarcoding-of-eukaryotes-in-marine-sediments
#2
Anders Lanzén, Katrine Lekang, Inge Jonassen, Eric M Thompson, Christofer Troedsson
Human impact on marine benthic communities has traditionally been assessed using visible morphological traits and has focused on the macrobenthos, whereas the ecologically important organisms of the meio- and microbenthos have received less attention. DNA metabarcoding offers an alternative to this approach and enables a larger fraction of the biodiversity in marine sediments to be monitored in a cost-efficient manner. Although this methodology remains poorly standardised and challenged by biases inherent to rRNA copy number variation, DNA extraction, PCR, and limitations related to taxonomic identification, it has been shown to be semi-quantitative and useful for comparing taxon abundances between samples...
2017: PloS One
https://www.readbyqxmd.com/read/28611731/the-genomic-architecture-of-novel-simulium-damnosum-wolbachia-prophage-sequence-elements-and-implications-for-onchocerciasis-epidemiology
#3
James L Crainey, Jacob Hurst, Poppy H L Lamberton, Robert A Cheke, Claire E Griffin, Michael D Wilson, Cláudia P Mendes de Araújo, María-Gloria Basáñez, Rory J Post
Research interest in Wolbachia is growing as new discoveries and technical advancements reveal the public health importance of both naturally occurring and artificial infections. Improved understanding of the Wolbachia bacteriophages (WOs) WOcauB2 and WOcauB3 [belonging to a sub-group of four WOs encoding serine recombinases group 1 (sr1WOs)], has enhanced the prospect of novel tools for the genetic manipulation of Wolbachia. The basic biology of sr1WOs, including host range and mode of genomic integration is, however, still poorly understood...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28608193/do-alternating-color-words-facilitate-reading-aloud-text-in-chinese-evidence-with-developing-and-adult-readers
#4
Manuel Perea, Xiaoyun Wang
Prior research has shown that colors induce perceptual grouping and, hence, colors can be used as word dividers during reading (Pinna & Deiana, 2014). This issue is particularly important for those writing systems that do not employ interword spaces (e.g., Chinese). The rationale is that alternating colors across words in these scripts may facilitate the process of word identification without altering the spatial distribution of text. Here, we tested whether color alternation across words produces a benefit in a reading-aloud task in native speakers of Chinese...
June 12, 2017: Memory & Cognition
https://www.readbyqxmd.com/read/28599646/agility-assessment-using-fuzzy-logic-approach-a-case-of-healthcare-dispensary
#5
M Suresh, Rojalin Patri
BACKGROUND: Agile concepts are not only beneficial for manufacturing sector but also for service sector such as healthcare. However, assessment of agility has been predominantly done in manufacturing enterprises. This study demonstrates a means to measure agility of a healthcare organization by assessing agility of a university dispensary. Its contribution to the knowledge base is twofold. First, it proposes a means to measure the agility of a healthcare organization and second, it identifies the attributes that prevent agile performance and outlines the suggestive measure to enhance its agile capabilities...
June 9, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28596713/performances-of-different-fragment-sizes-for-reduced-representation-bisulfite-sequencing-in-pigs
#6
Xiao-Long Yuan, Zhe Zhang, Rong-Yang Pan, Ning Gao, Xi Deng, Bin Li, Hao Zhang, Per Torp Sangild, Jia-Qi Li
BACKGROUND: Reduced representation bisulfite sequencing (RRBS) has been widely used to profile genome-scale DNA methylation in mammalian genomes. However, the applications and technical performances of RRBS with different fragment sizes have not been systematically reported in pigs, which serve as one of the important biomedical models for humans. The aims of this study were to evaluate capacities of RRBS libraries with different fragment sizes to characterize the porcine genome. RESULTS: We found that the MspI-digested segments between 40 and 220 bp harbored a high distribution peak at 74 bp, which were highly overlapped with the repetitive elements and might reduce the unique mapping alignment...
2017: Biological Procedures Online
https://www.readbyqxmd.com/read/28580916/cryo-electron-microscopy-of-chromatin-biology
#7
Marcus D Wilson, Alessandro Costa
The basic unit of chromatin, the nucleosome core particle (NCP), controls how DNA in eukaryotic cells is compacted, replicated and read. Since its discovery, biochemists have sought to understand how this protein-DNA complex can help to control so many diverse tasks. Recent electron-microscopy (EM) studies on NCP-containing assemblies have helped to describe important chromatin transactions at a molecular level. With the implementation of recent technical advances in single-particle EM, our understanding of how nucleosomes are recognized and read looks to take a leap forward...
June 1, 2017: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/28580659/ex-vivo-mri-evaluation-of-prostate-cancer-localization-and-margin-status-prediction-of-prostate-cancer-in-fresh-radical-prostatectomy-specimens
#8
Jan Heidkamp, Martijn Hoogenboom, Iringo E Kovacs, Andor Veltien, Arie Maat, J P Michiel Sedelaar, Christina A Hulsbergen-van de Kaa, Jurgen J Fütterer
PURPOSE: To investigate the ability of high field ex vivo magnetic resonance imaging (MRI) to localize prostate cancer (PCa) and to predict the margin status in fresh radical prostatectomy (RP) specimens using histology as the reference standard. MATERIALS AND METHODS: This Institutional Review Board (IRB)-approved study had written informed consent. Patients with biopsy-proved PCa and a diagnostic multiparametric 3T MRI examination of the prostate prior to undergoing RP were prospectively included...
June 5, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28574637/efficacy-and-safety-of-gadobutrol-enhanced-mra-of-the-renal-arteries-results-from-grams-gadobutrol-enhanced-renal-artery-mra-study-a-prospective-intraindividual-multicenter-phase-3-blinded-study
#9
Kelly E Fabrega-Foster, Sheela Agarwal, Neda Rastegar, Daniel Haverstock, Jacob M Agris, Ihab R Kamel
PURPOSE: To compare the performance of magnetic resonance angiography (MRA) with 1M gadobutrol, a high relaxivity macrocyclic contrast agent, to 2D time-of-flight MRA (ToF-MRA) using computed tomographic angiography (CTA) as the standard of reference. Primary objectives were evaluation for superiority of structural delineation and noninferiority for detection and exclusion of clinically significant disease. MATERIALS AND METHODS: In all, 315 subjects underwent unenhanced and contrast-enhanced MRA with 1M gadobutrol (CE-MRA) and were scanned with 1...
June 2, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28569453/prosthetic-complications-of-different-manufacturers-in-implant-supported-restorations-with-a-minimum-of-5-years-follow-up-systematic-literature-review
#10
Stefano Storelli, Massimo Scanferla, Giulia Palandrani, Daniela Mosca, Eugenio Romeo
INTRODUCTION: Prosthetic complications on implant supported restorations have been documented in several papers published in the literature. Several manufacturers are present on the market but results are often cumulated and may mislead the reader. The objective of the present review is to assess the prosthetic complications of implants supported restorations with particular interest of the results obtained by different manufacturers. EVIDENCE ACQUISITION: A Medline-pubmend and manual search were carried out up to June 2016, leading to 6832 articles that were narrowed to 1450 titles, then 347 abstract to include 55 papers after full text reading...
May 31, 2017: Minerva Stomatologica
https://www.readbyqxmd.com/read/28562672/rapid-detection-and-strain-typing-of-chlamydia-trachomatis-using-a-highly-multiplexed-microfluidic-pcr-assay
#11
Rosemary S Turingan, Ludmila Kaplun, Greice Krautz-Peterson, Sarah Norsworthy, Anna Zolotova, Sandeep J Joseph, Timothy D Read, Deborah Dean, Eugene Tan, Richard F Selden
Nucleic acid amplification tests (NAATs) are recommended by the CDC for detection of Chlamydia trachomatis (Ct) urogenital infections. Current commercial NAATs require technical expertise and sophisticated laboratory infrastructure, are time-consuming and expensive, and do not differentiate the lymphogranuloma venereum (LGV) strains that require a longer duration of treatment than non-LGV strains. The multiplexed microfluidic PCR-based assay presented in this work simultaneously interrogates 13 loci to detect Ct and identify LGV and non-LGV strain-types...
2017: PloS One
https://www.readbyqxmd.com/read/28560582/towards-standardization-of-18-f-fet-pet-imaging-do-we-need-a-consistent-method-of-background-activity-assessment
#12
Marcus Unterrainer, Franziska Vettermann, Matthias Brendel, Adrien Holzgreve, Michael Lifschitz, Matthias Zähringer, Bogdana Suchorska, Vera Wenter, Ben M Illigens, Peter Bartenstein, Nathalie L Albert
BACKGROUND: PET with O-(2-(18)F-fluoroethyl)-L-tyrosine ((18)F-FET) has reached increasing clinical significance for patients with brain neoplasms. For quantification of standard PET-derived parameters such as the tumor-to-background ratio, the background activity is assessed using a region of interest (ROI) or volume of interest (VOI) in unaffected brain tissue. However, there is no standardized approach regarding the assessment of the background reference. Therefore, we evaluated the intra- and inter-reader variability of commonly applied approaches for clinical (18)F-FET PET reading...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28553548/potential-utility-of-a-4k-consumer-camera-for-surgical-education-in-ophthalmology
#13
Tsunetomo Ichihashi, Yutaka Hirabayashi, Miyuki Nagahara
Purpose. We evaluated the potential utility of a cost-effective 4K consumer video system for surgical education in ophthalmology. Setting. Tokai University Hachioji Hospital, Tokyo, Japan. Design. Experimental study. Methods. The eyes that underwent cataract surgery, glaucoma surgery, vitreoretinal surgery, or oculoplastic surgery between February 2016 and April 2016 were recorded with 17.2 million pixels using a high-definition digital video camera (LUMIX DMC-GH4, Panasonic, Japan) and with 0.41 million pixels using a conventional analog video camera (MKC-501, Ikegami, Japan)...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28545404/gene-dispersion-is-the-key-determinant-of-the-read-count-bias-in-differential-expression-analysis-of-rna-seq-data
#14
Sora Yoon, Dougu Nam
BACKGROUND: In differential expression analysis of RNA-sequencing (RNA-seq) read count data for two sample groups, it is known that highly expressed genes (or longer genes) are more likely to be differentially expressed which is called read count bias (or gene length bias). This bias had great effect on the downstream Gene Ontology over-representation analysis. However, such a bias has not been systematically analyzed for different replicate types of RNA-seq data. RESULTS: We show that the dispersion coefficient of a gene in the negative binomial modeling of read counts is the critical determinant of the read count bias (and gene length bias) by mathematical inference and tests for a number of simulated and real RNA-seq datasets...
May 25, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28533985/metabarcoding-monitoring-analysis-the-pros-and-cons-of-using-co-extracted-environmental-dna-and-rna-data-to-assess-offshore-oil-production-impacts-on-benthic-communities
#15
Olivier Laroche, Susanna A Wood, Louis A Tremblay, Gavin Lear, Joanne I Ellis, Xavier Pochon
Sequencing environmental DNA (eDNA) is increasingly being used as an alternative to traditional morphological-based identification to characterize biological assemblages and monitor anthropogenic impacts in marine environments. Most studies only assess eDNA which, compared to eRNA, can persist longer in the environment after cell death. Therefore, eRNA may provide a more immediate census of the environment due to its relatively weaker stability, leading some researchers to advocate for the use of eRNA as an additional, or perhaps superior proxy for portraying ecological changes...
2017: PeerJ
https://www.readbyqxmd.com/read/28511174/noninvasive-prenatal-detection-of-trisomy-21-by-targeted-semiconductor-sequencing-a-technical-feasibility-study
#16
Yanwei Xi, Aryan Arbabi, Amy J M McNaughton, Alison Hamilton, Danna Hull, Helene Perras, Tillie Chiu, Shawna Morrison, Claire Goldsmith, Emilie Creede, Gregory J Anger, Christina Honeywell, Mireille Cloutier, Natasha Macchio, Courtney Kiss, Xudong Liu, Susan Crocker, Gregory A Davies, Michael Brudno, Christine M Armour
OBJECTIVE: To develop an alternate noninvasive prenatal testing method for the assessment of trisomy 21 (T21) using a targeted semiconductor sequencing approach. METHODS: A customized AmpliSeq panel was designed with 1,067 primer pairs targeting specific regions on chromosomes 21, 18, 13, and others. A total of 235 samples, including 30 affected with T21, were sequenced with an Ion Torrent Proton sequencer, and a method was developed for assessing the probability of fetal aneuploidy via derivation of a risk score...
May 17, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28499931/empowered-to-cook-the-crucial-role-of-food-agency-in-making-meals
#17
Amy B Trubek, Maria Carabello, Caitlin Morgan, Jacob Lahne
What makes an individual, on any given occasion, able and willing to prepare a meal for themselves: that is, to cook? As home cooking has increasingly become the focus of public-health, nutrition, and policy interventions and campaigns, the need for a better understanding has become apparent. It is clear that cooking is not merely a matter of mechanical skill or rote training; beyond this, it is difficult to explain why similar individuals have such different capacities for setting and achieving food-related goals...
May 9, 2017: Appetite
https://www.readbyqxmd.com/read/28495815/understanding-the-implementation-and-adoption-of-an-information-technology-intervention-to-support-medicine-optimisation-in-primary-care-qualitative-study-using-strong-structuration-theory
#18
Mark Jeffries, Denham Phipps, Rachel L Howard, Anthony Avery, Sarah Rodgers, Darren Ashcroft
OBJECTIVES: Using strong structuration theory, we aimed to understand the adoption and implementation of an electronic clinical audit and feedback tool to support medicine optimisation for patients in primary care. DESIGN: This is a qualitative study informed by strong structuration theory. The analysis was thematic, using a template approach. An a priori set of thematic codes, based on strong structuration theory, was developed from the literature and applied to the transcripts...
May 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28486694/differential-microrna-expression-in-cultured-palatal-fibroblasts-from-infants-with-cleft-palate-and-controls
#19
Christian Schoen, Jeffrey C Glennon, Shaghayegh Abghari, Marjon Bloemen, Armaz Aschrafi, Carine E L Carels, Johannes W Von den Hoff
Background: The role of microRNAs (miRNAs) in animal models of palatogenesis has been shown, but only limited research has been carried out in humans. To date, no miRNA expression study on tissues or cells from cleft palate patients has been published. We compared miRNA expression in palatal fibroblasts from cleft palate patients and age-matched controls. Material and Methods: Cultured palatal fibroblasts from 10 non-syndromic cleft lip and palate patients (nsCLP; mean age: 18 ± 2 months), 5 non-syndromic cleft palate only patients (nsCPO; mean age: 17 ± 2 months), and 10 controls (mean age: 24 ± 5 months) were analysed with next-generation small RNA sequencing...
May 9, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28483172/-environment-trauma-and-technical-innovations-three-links-between-donald-w-winnicott-and-s%C3%A3-ndor-ferenczi
#20
Miguel Gutiérrez-Peláez, Emilio Herrera-Pardo
Throughout this paper, the theoretical and clinical approaches of D.W. Winnicott are reviewed in order to reread the written production of Sándor Ferenczi. Winnicott's clinical and theoretical concepts allow returning to Ferenczi and rescuing aspects of his work that had been silenced in the psychoanalytic community. Ferenczi, in turn, is one that holds his presence in Winnicott's thought. Even though there are few times in which he cites Ferenczi in his work, it is possible to draw clear relationships between both theories...
April 2017: Revista Colombiana de Psiquiatría
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