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https://www.readbyqxmd.com/read/28213593/randomised-double-blind-parallel-group-placebo-controlled-study-to-evaluate-the-analgesic-efficacy-and-safety-of-vvz-149-injections-for-postoperative-pain-following-laparoscopic-colorectal-surgery
#1
Srdjan S Nedeljkovic, Darin J Correll, Xiaodong Bao, Natacha Zamor, Jose L Zeballos, Yi Zhang, Mark J Young, Johanna Ledley, Jessica Sorace, Kristen Eng, Carlyle P Hamsher, Rajivan Maniam, Jonathan W Chin, Becky Tsui, Sunyoung Cho, Doo H Lee
INTRODUCTION: In spite of advances in understanding and technology, postoperative pain remains poorly treated for a significant number of patients. In colorectal surgery, the need for developing novel analgesics is especially important. Patients after bowel surgery are assessed for rapid return of bowel function and opioids worsen ileus, nausea and constipation. We describe a prospective, double-blind, parallel group, placebo-controlled randomised controlled trial testing the hypothesis that a novel analgesic drug, VVZ -149, is safe and effective in improving pain compared with providing opioid analgesia alone among adults undergoing laparoscopic colorectal surgery...
February 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28212394/de-novo-transcriptome-analysis-and-microsatellite-marker-development-for-population-genetic-study-of-a-serious-insect-pest-rhopalosiphum-padi-l-hemiptera-aphididae
#2
Xinle Duan, Kang Wang, Sha Su, Ruizheng Tian, Yuting Li, Maohua Chen
The bird cherry-oat aphid, Rhopalosiphum padi (L.), is one of the most abundant aphid pests of cereals and has a global distribution. Next-generation sequencing (NGS) is a rapid and efficient method for developing molecular markers. However, transcriptomic and genomic resources of R. padi have not been investigated. In this study, we used transcriptome information obtained by RNA-Seq to develop polymorphic microsatellites for investigating population genetics in this species. The transcriptome of R. padi was sequenced on an Illumina HiSeq 2000 platform...
2017: PloS One
https://www.readbyqxmd.com/read/28212382/de-novo-assembly-of-the-sea-trout-salmo-trutta-m-trutta-skin-transcriptome-to-identify-putative-genes-involved-in-the-immune-response-and-epidermal-mucus-secretion
#3
Magdalena Malachowicz, Roman Wenne, Artur Burzynski
In fish, the skin is a multifunctional organ and the first barrier against pathogens. Salmonids differ in their susceptibility to microorganisms due to varied skin morphology and gene expression patterns. The brown trout is a salmonid species with important commercial and ecological value in Europe. However, there is a lack of knowledge regarding the genes involved in the immune response and mucus secretion in the skin of this fish. Thus, we characterized the skin transcriptome of anadromous brown trout using next-generation sequencing (NGS)...
2017: PloS One
https://www.readbyqxmd.com/read/28205112/autochthonous-sporadic-acute-hepatitis-e-caused-by-two-distinct-subgenotype-3b-hepatitis-e-virus-strains-with-only-90-nucleotide-identity
#4
Yasuko Yamaguchi, Hitoshi Takagi, Yuhei Suzuki, Kyoko Maruhashi, Takashi Kosone, Satoru Kakizaki, Ken Sato, Masanobu Yamada, Shigeo Nagashima, Masaharu Takahashi, Hiroaki Okamoto
Hepatitis E, which is caused by hepatitis E virus (HEV), is a public health concern in Japan, where the zoonotic food-borne transmission of HEV from domestic pigs and wild boars plays an important role. A 44-year-old Japanese man with autochthonous sporadic acute hepatitis E was admitted with general fatigue and moderate liver dysfunction. In the present study, two distinct HEV strains were recovered from the patient, who had consumed the raw or undercooked pig liver and intestine two or three times per week for 3 months before the disease onset...
February 15, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28205052/a-novel-subgenotype-3a-hepatitis-e-virus-isolated-from-pigs-in-china
#5
Yufeng Cao, Lisai Zhu, Dan Liu, Changming Guo, Yue Yuan, Chengbo Shi, Zhaohui Liu, Xinping Wang
Hepatitis E virus (HEV) infection is an emerging disease with zoonotic transmission that represents a serious public health concern, especially in developing countries. Here we characterize a novel HEV strain CCST-517, which possesses a complete genome sequence of 7284 bp with typical HEV genome organization including 5' and 3' non-coding regions and three open reading frames. The sequence identities of CCST-517 with known HEV genotype 1, 2, 3, and 4 were 73.4-73.7, 73.2, 80.4-90.4, and 75.1-75.7%, respectively...
February 15, 2017: Virus Genes
https://www.readbyqxmd.com/read/28196101/de-novo-assembly-characterization-and-annotation-for-the-transcriptome-of-sarcocheilichthys-sinensis
#6
Chuankun Zhu, Zhengjun Pan, Hui Wang, Guoliang Chang, Nan Wu, Huaiyu Ding
The Chinese lake gudgeon Sarcocheilichthys sinensis is a small cyprinid fish with great aquaculture potential both for its edible and ornamental values. Nevertheless, available genomic and transcriptomic information for this fish is extremely deficient. In this study, a normalized cDNA library was constructed using 13 mixed tissues of an adult male S. sinensis, and was sequenced by the Illumina HiSeq2500 platform. De novo assembly was performed using 38,911,511 obtained clean reads, and a total of 147,282 unigenes with an average length of 900 bp were finally achieved...
2017: PloS One
https://www.readbyqxmd.com/read/28191331/development-of-dual-taqman-based-one-step-rrt-pcr-assay-panel-for-rapid-and-accurate-diagnostic-test-of-mers-cov-a-novel-human-coronavirus-ahead-of-hajj-pilgrimage
#7
Mohammad Sadegh Hashemzadeh, Rahimeh Rasouli, Bentolhoda Zahraei, Morteza Izadi, Mahdi Tat, Seyed Hassan Saadat, Mohammad Najarasl, Behzad Khansari Nejad, Ruhollah Dorostkar
BACKGROUND: Coronaviruses (CoVs) are large ribonucleic acid (RNA) viruses causing primarily respiratory disease in humans. A novel human coronavirus, subsequently named middle east respiratory syndrome coronavirus (MERS-CoV), was first reported in Saudi Arabia in September of 2012. With increasing numbers of infections and deaths from MERS-CoV, development of a rapid and reliable kit was crucial to prevent further spread of MERS-CoV. OBJECTIVES: In this study, we present two real-time reverse-transcription polymerase chain reaction (rRT-PCR) assays for in-house rapid and sensitive diagnostic testing of MERS-CoV, detecting the regions upstream of the envelope gene (upE) and open reading frame (ORF) 1b, respectively, for initial screening and final confirmation of MERS-CoV infection, as recommended by the world health organization (WHO)...
November 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28190789/in-the-25th-year-of-bioethics-publishing-new-challenges-of-the-post-truth-era
#8
Amar Jesani
As IJME enters its 25th year of publication, all of us closely associated with the journal look back on this journey with a degree of satisfaction. Not only has the only bioethics journal published from India survived for 24 years, it has also produced some extraordinary successes. As you read this issue, we will be celebrating the 12th year of the biennial National Bioethics Conferences - the sixth NBC will take place in Pune from January 13 to 15, 2017.
January 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28187953/factors-related-to-early-intervention-part-c-enrollment-a-systematic-review
#9
REVIEW
Erica Twardzik, Coral Cotto-Negrón, Megan MacDonald
BACKGROUND: The first few years of life are critical for the healthy growth and development of every child. Enrolling children with disabilities or at risk of developmental delay into early intervention services is essential to successfully meet their physical, cognitive, communication, socio-emotional and adaptive needs. However, many children throughout in the United States who are eligible for public services, including early intervention services, are not accessing them. Research has yet to fully describe low enrollment rates and variability in enrollment into early intervention services...
January 28, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28187410/jllumina-a-comprehensive-java-based-api-for-statistical-illumina-infinium-humanmethylation450-and-methylationepic-data-processing
#10
Diogo Almeida, Ida Skov, Jesper Lund, Afsaneh Mohammadnejad, Artur Silva, Fabio Vandin, Qihua Tan, Jan Baumbach, Richard Röttger
Measuring differential methylation of the DNA is the nowadays most common approach to linking epigenetic modifications to diseases (called epigenome-wide association studies, EWAS). For its low cost, its efficiency and easy handling, the Illumina HumanMethylation450 BeadChip and its successor, the Infinium MethylationEPIC BeadChip, is the by far most popular techniques for conduction EWAS in large patient cohorts. Despite the popularity of this chip technology, raw data processing and statistical analysis of the array data remains far from trivial and still lacks dedicated software libraries enabling high quality and statistically sound downstream analyses...
December 18, 2016: Journal of Integrative Bioinformatics
https://www.readbyqxmd.com/read/28184917/-corrigendum-loss-of-runt%C3%A2-related-transcription-factor%C3%A2-3-induces-resistance-to-5%C3%A2-fluorouracil-and-cisplatin-in-hepatocellular-carcinoma
#11
Junro Kataoka, Hidenori Shiraha, Shigeru Horiguchi, Hiroaki Sawahara, Daisuke Uchida, Teruya Nagahara, Masaya Iwamuro, Hiroki Morimoto, Yasuto Takeuchi, Kenji Kuwaki, Hideki Onishi, Shinichiro Nakamura, Akinobu Takaki, Kazuhiro Nouso, Takahito Yagi, Kazuhide Yamamoto, Hiroyuki Okada
Following the publication of this article, we realize that there were some errors in the manuscript. Details of the experiments describing the gene silencing of RUNX3 with small interfering RNA (siRNA) were erroneously included in this paper, and all references to siRNA should have been deleted from the manuscript prior to publication. In the subsection entitled 'Cell lines and cell culture' on page 2577, the left‑hand column, the text should have indicated that the human HCC cell lines Hep3B and Huh7 were obtained from the American Type Culture Collection (ATCC; Manassas, VA, USA), whereas HLF cells were obtained from the Japanese Cancer Resources Bank (Tokyo, Japan)...
March 2017: Oncology Reports
https://www.readbyqxmd.com/read/28182805/assessment-of-readability-understandability-and-completeness-of-pediatric-hospital-medicine-discharge-instructions
#12
Ndidi I Unaka, Angela Statile, Julianne Haney, Andrew F Beck, Patrick W Brady, Karen E Jerardi
The average American adult reads at an 8th-grade level. Discharge instructions written above this level might increase the risk of adverse outcomes for children as they transition from hospital to home. We conducted a cross-sectional study at a large urban academic children's hospital to describe readability levels, understandability scores, and completeness of written instructions given to families at hospital discharge. Two hundred charts for patients discharged from the hospital medicine service were randomly selected for review...
February 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28182452/correction-to-kinnunen-et-al-2016
#13
(no author information available yet)
Reports an error in "Linking Boundary Crossing from Work to Nonwork to Work-Related Rumination across Time: A Variable- and Person-Oriented Approach" by Ulla Kinnunen, Taru Feldt, Jessica de Bloom, Marjaana Sianoja, Kalevi Korpela and Sabine Geurts (Journal of Occupational Health Psychology, Advanced Online Publication, Apr 28, 2016, np). In the original article, there were errors in "The Present Study" section and in the "Identifying Subgroups of Boundary Crossing Behavior Across Time" subsection of the "Results" section...
February 9, 2017: Journal of Occupational Health Psychology
https://www.readbyqxmd.com/read/28179634/rapid-and-cost-effective-high-throughput-sequencing-for-identification-of-germline-mutations-of-brca1-and-brca2
#14
Somayeh Ahmadloo, Hirofumi Nakaoka, Takahide Hayano, Kazuyoshi Hosomichi, Hua You, Emi Utsuno, Takafumi Sangai, Motoi Nishimura, Kazuyuki Matsushita, Akira Hata, Fumio Nomura, Ituro Inoue
Genetic testing for breast cancer predisposing genes, BRCA1 and BRCA2, can take advantage for early identification of carriers with pathogenic germline mutations. However, conventional approaches based on Sanger sequencing are laborious and expensive. Next-generation sequencing technology has a great impact on investigation of medical genomics and now applied clinical genetics. We provide a protocol based on a pool and capture method followed by high-throughput sequencing, which realizes a rapid, high-quality, high-accuracy and low-cost testing for mutations in BRCA1 and BRCA2 by using small amounts of input DNA...
February 9, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28172359/ciipro-a-new-read-across-portal-to-fill-data-gaps-using-public-large-scale-chemical-and-biological-data
#15
Daniel P Russo, Marlene T Kim, Wenyi Wang, Daniel Pinolini, Sunil Shende, Judy Strickland, Thomas Hartung, Hao Zhu
No abstract text is available yet for this article.
February 1, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28170372/prognostication-and-monitoring-of-mesothelioma-using-biomarkers-a-systematic-review
#16
David T Arnold, Duneesha De Fonseka, Fergus W Hamilton, Najib M Rahman, Nick A Maskell
BACKGROUND: Radiological markers of treatment response and prognostication in malignant pleural mesothelioma have limitations due to the morphology of the disease. Serum or pleural fluid biomarkers that could act as an adjunct to radiological assessment would be of significant value. The aim of this review was to collate and summarise the literature relating to this topic. METHODS: A systematic review was performed on the databases Pubmed and EMBASE to identify relevant studies...
February 7, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28165358/extending-immunological-profiling-in-the-gilthead-sea-bream-sparus-aurata-by-enriched-cdna-library-analysis-microarray-design-and-initial-studies-upon-the-inflammatory-response-to-pamps
#17
Sebastian Boltaña, Barbara Castellana, Giles Goetz, Lluis Tort, Mariana Teles, Victor Mulero, Beatriz Novoa, Antonio Figueras, Frederick W Goetz, Cristian Gallardo-Escarate, Josep V Planas, Simon Mackenzie
This study describes the development and validation of an enriched oligonucleotide-microarray platform for Sparus aurata (SAQ) to provide a platform for transcriptomic studies in this species. A transcriptome database was constructed by assembly of gilthead sea bream sequences derived from public repositories of mRNA together with reads from a large collection of expressed sequence tags (EST) from two extensive targeted cDNA libraries characterizing mRNA transcripts regulated by both bacterial and viral challenge...
February 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28162866/perceptions-and-knowledge-of-caffeinated-energy-drinks-results-of-focus-groups-with-canadian-youth
#18
Cassondra McCrory, Christine M White, Carolyn Bowman, Nancy Fenton, Jessica L Reid, David Hammond
OBJECTIVE: To examine use, knowledge, and perceptions of caffeinated energy drinks (CEDs) among youth. DESIGN: Qualitative research using focus group discussions (n = 4). SETTING: Two Canadian cities (Toronto and Montreal). PARTICIPANTS: Youth aged 12-18 years (n = 41). PHENOMENON OF INTEREST: Perceived definitions of CEDs, reasons for use, knowledge of health effects, use with alcohol, marketing perceptions, and use and understanding of cautionary statements on packaging...
February 2, 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/28161815/next-generation-sequencing-of-representational-difference-analysis-products-for-identification-of-genes-involved-in-diosgenin-biosynthesis-in-fenugreek-trigonella-foenum-graecum
#19
Joanna Ciura, Magdalena Szeliga, Michalina Grzesik, Mirosław Tyrka
Representational difference analysis of cDNA was performed and differential products were sequenced and annotated. Candidate genes involved in biosynthesis of diosgenin in fenugreek were identified. Detailed mechanism of diosgenin synthesis was proposed. Fenugreek (Trigonella foenum-graecum L.) is a valuable medicinal and crop plant. It belongs to Fabaceae family and has a unique potential to synthesize valuable steroidal saponins, e.g., diosgenin. Elicitation (methyl jasmonate) and precursor feeding (cholesterol and squalene) were used to enhance the content of sterols and steroidal sapogenins in in vitro grown plants for representational difference analysis of cDNA (cDNA-RDA)...
February 4, 2017: Planta
https://www.readbyqxmd.com/read/28160400/exploring-the-facets-of-empathy-and-pain-in-clinical-practice-a-review
#20
REVIEW
Jenny Roche, Dominic Harmon
BACKGROUND: Empathy is an essential element in providing quality patient care. The significance of empathy is even more striking in pain medicine, as chronic pain is notorious for the way it can compromise an individual, leaving him or her isolated and feeling misconceived. This review examines the role of empathy in pain medicine practice. METHODS: Current and past literature focusing on empathy and pain was searched for in PubMed, Science Direct, Medline (Ovid), Medline (Ebsco), Research Gate, and Google Scholar in July 2015...
February 3, 2017: Pain Practice: the Official Journal of World Institute of Pain
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