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https://www.readbyqxmd.com/read/29331949/bibliometric-analysis-of-military-trauma-publications-2000-2016
#1
Mark L Vickers, C P Coorey, G J Milinovich, L Eriksson, M Assoum, M C Reade
INTRODUCTION: Bibliometric tools can be used to identify the authors, topics and research institutions that have made the greatest impact in a field of medicine. The aim of this research was to analyse military trauma publications over the last 16 years of armed conflict in order to highlight the most important lessons that have translated into civilian practice and military doctrine as well as identify emerging areas of importance. METHODS: A systematic search of research published between January 2000 and December 2016 was conducted using the Thompson Reuters Web of Science database...
January 13, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29329394/analysis-of-the%C3%A2-aedes-albopictus%C3%A2-c6-36-genome-provides-insight-into-cell-line-utility-for-viral-propagation
#2
Jason R Miller, Sergey Koren, Kari A Dilley, Vinita Puri, David M Brown, Derek M Harkins, Françoise Thibaud-Nissen, Benjamin Rosen, Xiao-Guang Chen, Zhijian Tu, Igor V Sharakhov, Maria V Sharakhova, Robert Sebra, Timothy B Stockwell, Nicholas H Bergman, Granger G Sutton, Adam M Phillippy, Peter M Piermarini, Reed S Shabman
Background: The 50-year old Aedes albopictus C6/36 cell line is a resource for the detection, amplification, and analysis of mosquito-borne viruses including Zika, dengue, and chikungunya. The cell line is derived from an unknown number of larvae from an unspecified strain of Aedes albopictus mosquitoes. Toward improved utility of the cell line for research in virus transmission, we present an annotated assembly of the C6/36 genome. Results: The C6/36 genome assembly has the largest contig N50 (3...
January 10, 2018: GigaScience
https://www.readbyqxmd.com/read/29328064/south-african-eye-study-saes-ethnic-differences-in-central-corneal-thickness-and-intraocular-pressure
#3
S O Baboolal, D P Smit
PurposeGlaucoma is the leading cause of irreversible blindness worldwide. South Africa has a diverse population but there is a lack of published ethnic specific normative data. The purpose of the study is to determine the distribution of intraocular pressure (IOP) and central corneal thickness (CCT) values in a multi-ethnic South African population and to determine additional systemic and ocular factors that influence IOP and CCT.Patients and methodsThis cross-sectional study included a total of 402 participants with 706 eyes aged 18-94 years...
January 12, 2018: Eye
https://www.readbyqxmd.com/read/29325164/sleep-duration-in-the-united-states-2003-2016-first-signs-of-success-in-the-fight-against-sleep-deficiency
#4
Mathias Basner, David F Dinges
Study Objectives: The high prevalence of chronic insufficient sleep in the population has been a concern due to the associated health and safety risks. We evaluated secular trends in sleep duration over the most recent 14-year period. Methods: The American Time Use Survey (ATUS), representative of US residents ≥15 years, was used to investigate trends in self-reported sleep duration and waking activities for the period 2003-2016 (N=181,335 respondents). Results: Sleep duration increased across survey years both on weekdays (+1...
January 8, 2018: Sleep
https://www.readbyqxmd.com/read/29324854/characterization-of-the-biosynthetic-gene-cluster-for-cryptic-phthoxazolin-a-in-streptomyces-avermitilis
#5
Dian Anggraini Suroto, Shigeru Kitani, Masayoshi Arai, Haruo Ikeda, Takuya Nihira
Phthoxazolin A, an oxazole-containing polyketide, has a broad spectrum of anti-oomycete activity and herbicidal activity. We recently identified phthoxazolin A as a cryptic metabolite of Streptomyces avermitilis that produces the important anthelmintic agent avermectin. Even though genome data of S. avermitilis is publicly available, no plausible biosynthetic gene cluster for phthoxazolin A is apparent in the sequence data. Here, we identified and characterized the phthoxazolin A (ptx) biosynthetic gene cluster through genome sequencing, comparative genomic analysis, and gene disruption...
2018: PloS One
https://www.readbyqxmd.com/read/29322438/genome-wide-circrna-profiling-from-rna-seq-data
#6
Daphne A Cooper, Mariela Cortés-López, Pedro Miura
The genome-wide expression patterns of circular RNAs (circRNAs) are of increasing interest for their potential roles in normal cellular homeostasis, development, and disease. Thousands of circRNAs have been annotated from various species in recent years. Analysis of publically available or user-generated rRNA-depleted total RNA-seq data can be performed to uncover new circRNA expression trends. Here we provide a primer for profiling circRNAs from RNA-seq datasets. The description is tailored for the wet lab scientist with limited or no experience in analyzing RNA-seq data...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29321980/transcriptome-sequencing-and-de-novo-assembly-in-arecanut-areca-catechu-l-elucidates-the-secondary-metabolite-pathway-genes
#7
Ramaswamy Manimekalai, Smita Nair, A Naganeeswaran, Anitha Karun, Suresh Malhotra, V Hubbali
Areca catechu L. belongs to the Arecaceae family which comprises many economically important palms. The palm is a source of alkaloids and carotenoids. The lack of ample genetic information in public databases has been a constraint for the genetic improvement of arecanut. To gain molecular insight into the palm, high throughput RNA sequencing and de novo assembly of arecanut leaf transcriptome was undertaken in the present study. A total 56,321,907 paired end reads of 101 bp length consisting of 11.343 Gb nucleotides were generated...
March 2018: Biotechnology Reports
https://www.readbyqxmd.com/read/29321068/psychosocial-issues-discovered-through-reflective-group-dialogue-between-medical-students
#8
Shao-Yin Chu, Chi-Wei Lin, Meei-Ju Lin, Chin-Chen Wen
BACKGROUND: The biopsychosocial model is a comprehensive approach emphasizing holistic medical care. However, medical curricula that incorporate narrative reflective writing and group dynamic discussion of psychosocial issues among patients and their family members in reflective dialogue groups are currently underutilized. The aim of this study was to determine psychosocial issues among patients and their family members through medical students' reflective dialogue groups. METHODS: This study was completed as part of a pediatric clerkship...
January 10, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29320804/misidentification-of-genome-assemblies-in-public-databases-the-case-of-naumovozyma-dairenensis-and-proposal-of-a-protocol-to-correct-misidentifications
#9
Aimilia A Stavrou, Verónica Mixão, Teun Boekhout, Toni Gabaldón
Online sequence databases such as NCBI GenBank serve as a tremendously useful platform for researchers to share and reuse published data. However, submission systems lack control for errors such as organism misidentification, which once entered in the database can be propagated and mislead downstream analyses. Here we present an illustrating case of misidentification of Candida albicans from a clinical sample as Naumovozyma dairenensis based on whole-genome shotgun data. Analyses of phylogenetic markers, read mapping and single nucleotide polymorphisms (SNP) served to correct the identification...
January 10, 2018: Yeast
https://www.readbyqxmd.com/read/29320504/evaluation-of-the-practicability-and-virological-performance-of-finger-stick-whole-blood-hiv-self-testing-in-french-speaking-sub-saharan-africa
#10
Serge Tonen-Wolyec, Salomon Batina-Agasa, Jérémie Muwonga, Franck Fwamba N'kulu, Ralph-Sydney Mboumba Bouassa, Laurent Bélec
BACKGROUND: Opportunities for HIV testing could be enhanced by offering HIV self-testing (HIVST) in populations that fear stigma and discrimination when accessing conventional HIV counselling and testing in health care facilities. Field experience with HIVST has not yet been reported in French-speaking African countries. METHODS: The practicability of HIVST was assessed using the prototype the Exacto® Test HIV (Biosynex, Strasbourg, France) self-test in 322 adults living in Kisangani and Bunia, Democratic Republic of the Congo, according to World Health Organization's recommendations...
2018: PloS One
https://www.readbyqxmd.com/read/29317925/supporting-shared-decision-making-and-people-s-understanding-of-medicines-an-exploration-of-the-acceptability-and-comprehensibility-of-patient-information
#11
Katie Gibson Smith, Jill L Booth, Derek Stewart, Sharon Pfleger, Laura Mciver, Kathrine Maclure
Background: Patient information may assist in promoting shared decision-making, however it is imperative that the information presented is comprehensible and acceptable to the target audience. Objective: This study sought to explore the acceptability and comprehensibility of the ' Medicines in Scotland: What's the right treatment for you?' factsheet to the general public. Methods: Qualitative semi-structured telephone interviews were conducted with members of the public...
October 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/29316298/improving-the-safety-assessment-of-chemicals-and-drug-candidates-by-the-integration-of-bio-informatics-and-chemoinformatics-data
#12
Thomas Steger-Hartmann, Francois Pognan
The application of read-across and in silico tools for regulatory decision-making has been limited for pharmaceutical compounds to the assessment of genotoxic impurity. In contrast, the broad availability of toxicity data for industrial chemicals has triggered regulatory frameworks for read-across (e.g. ECHA read-across assessment framework), software tools and public databases for an automated process of gap filling for safety assessment framework. This MiniReview provides an overview of the currently existing in silico and read-across approaches for chemicals together with recent developments for pharmaceutical compounds in these areas...
January 7, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29313731/the-effectiveness-of-a-parental-guide-for-prevention-of-problematic-video-gaming-in-children-a-public-health-randomized-controlled-intervention-study
#13
Elfrid Krossbakken, Torbjørn Torsheim, Rune Aune Mentzoni, Daniel Luke King, Bjørn Bjorvatn, Ingjerd Meen Lorvik, Ståle Pallesen
Background and aims Excessive use of video games among children and adolescents is a growing concern. The aim of this study was to investigate the effectiveness of a brief parental guide with advices and strategies for regulating video gaming in children. Methods A random sample of guardians of children between the age of 8-12 years old (N = 5,864) was drawn from the Norwegian Population Registry and equally randomized into an intervention and a control condition. A parental guide based on clinical and research literature was distributed by postal mail to those in the intervention condition...
January 9, 2018: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/29312831/translating-genomics-into-practice-for-real-time-surveillance-and-response-to-carbapenemase-producing-enterobacteriaceae-evidence-from-a-complex-multi-institutional-kpc-outbreak
#14
Jason C Kwong, Courtney R Lane, Finn Romanes, Anders Gonçalves da Silva, Marion Easton, Katie Cronin, Mary Jo Waters, Takehiro Tomita, Kerrie Stevens, Mark B Schultz, Sarah L Baines, Norelle L Sherry, Glen P Carter, Andre Mu, Michelle Sait, Susan A Ballard, Torsten Seemann, Timothy P Stinear, Benjamin P Howden
Background: Until recently, Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae were rarely identified in Australia. Following an increase in the number of incident cases across the state of Victoria, we undertook a real-time combined genomic and epidemiological investigation. The scope of this study included identifying risk factors and routes of transmission, and investigating the utility of genomics to enhance traditional field epidemiology for informing management of established widespread outbreaks...
2018: PeerJ
https://www.readbyqxmd.com/read/29311113/the-genomes-of-four-meyerozymacaribbica-isolates-and-novel-insights-into-the-meyerozymaguilliermondii-species-complex
#15
Leone De Marco, Sara Epis, Aida Capone, Elena Martin, Jovana Bozic, Elena Crotti, Irene Ricci, Davide Sassera
Yeasts of the Meyerozyma guilliermondii species complex are widespread in nature and can be isolated from a variety of sources, from the environment to arthropods to hospital patients. To date, the species complex comprises the thoroughly studied and versatile M. guilliermondii, and the hard to distinguish M. caribbica, and Candida carpophila Here we report the whole-genome sequencing and de novo assembly of four M. caribbica isolates, identified with the most recent molecular techniques, derived from four Diptera species...
January 8, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29310610/pregnancy-outcomes-in-women-taking-probiotics-or-prebiotics-a-systematic-review-and-meta-analysis
#16
Alexander Jarde, Anne-Mary Lewis-Mikhael, Paul Moayyedi, Jennifer C Stearns, Stephen M Collins, Joseph Beyene, Sarah D McDonald
BACKGROUND: Probiotics are living microorganisms that, when administered in adequate amounts, confer a health benefit. It has been speculated that probiotics might help prevent preterm birth, but in two previous systematic reviews possible major increases in this risk have been suggested. Our objective was to perform a systematic review and meta-analysis of the risk of preterm birth and other adverse pregnancy outcomes in pregnant women taking probiotics, prebiotics or synbiotics. METHODS: We searched six electronic databases (MEDLINE, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials, Web of Science's Core collection and BIOSIS Preview) up to September 2016 and contacted authors for additional data...
January 8, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29310597/de-novo-transcriptome-assembly-annotation-and-comparison-of-four-ecological-and-evolutionary-model-salmonid-fish-species
#17
Madeleine Carruthers, Andrey A Yurchenko, Julian J Augley, Colin E Adams, Pawel Herzyk, Kathryn R Elmer
BACKGROUND: Salmonid fishes exhibit high levels of phenotypic and ecological variation and are thus ideal model systems for studying evolutionary processes of adaptive divergence and speciation. Furthermore, salmonids are of major interest in fisheries, aquaculture, and conservation research. Improving understanding of the genetic mechanisms underlying traits in these species would significantly progress research in these fields. Here we generate high quality de novo transcriptomes for four salmonid species: Atlantic salmon (Salmo salar), brown trout (Salmo trutta), Arctic charr (Salvelinus alpinus), and European whitefish (Coregonus lavaretus)...
January 8, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29305080/de-novo-transcriptomic-analysis-of-the-venomous-glands-from-the-scorpion-heterometrus-spinifer-revealed-unique-and-extremely-high-diversity-of-the-venom-peptides
#18
Yuchen Deng, Jiawei Gu, Zhenpeng Yan, Mengdi Wang, Chaoqun Ma, Jiafeng Zhang, Guixian Jiang, Mengxiao Ge, Shuogui Xu, Zheng Xu, Liang Xiao
Scorpion, as an ancient species, has been widely used on dozens of human diseases in traditional Chinese Medicine. Although the scorpion venom from the Buthidae family with the potent toxicity attracts more interests, toxins from the non-Buthidae family draw great attention as well because of its abundance and complexity even without harm to mammals. Moreover, several toxic components of scorpion venom have been identified as valuable scaffolds for the drug design and development. Using the Next Generation Sequencing (NGS) technique, here we reported the transcriptome of the venomous glands of Heterometrus spinifer, a non-Buthidae scorpion that only a few toxic and complete components have been identified known-to-date...
January 2, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29304473/bariatric-surgery-as-a-risk-factor-in-the-development-of-dental-caries-a-systematic-review
#19
REVIEW
A O Salgado-Peralvo, M V Mateos-Moreno, L Arriba-Fuente, Á García-Sánchez, A Salgado-García, V Peralvo-García, M Millán-Yanes
OBJECTIVES: Obesity is one of the most prevalent chronic pathologies in the world and has become a public health problem. At the present time, bariatric surgery (BS) is considered the best option and the only effective method of treatment, but it can occasionally result in a series of alterations at the oral level. This study aims to review the current literature to establish the possible association of patients who have undergone BS and a greater risk of dental caries. STUDY DESIGN: This study is a systematic review of the literature...
January 2, 2018: Public Health
https://www.readbyqxmd.com/read/29304313/the-doctor-of-delayed-publications-the-remarkable-life-of-george-streisinger-1927-1984
#20
Máté Varga
The history of science offers multiple examples of how the perseverance of a single visionary person could open the floodgates for a whole new area of research. Zebrafish research is one of these fields with an exciting founding story, as it was the dogged persistence of one man, George Streisinger, that ultimately lifted this little fish out of the obscurity of pet shops into the pantheon of genetic model organisms. The Hungarian born Streisinger was one of the most gifted geneticists of his era and his network of mentors and friends really reads like a who-is-who of 20th century genetics...
January 5, 2018: Zebrafish
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