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https://www.readbyqxmd.com/read/28813003/self-assessment-of-antimicrobial-stewardship-in-primary-care-self-reported-practice-using-the-target-primary-care-self-assessment-tool
#1
Rebecca Owens, Leah Ffion Jones, Michael Moore, Dirk Pilat, Cliodna McNulty
Multifaceted antimicrobial stewardship (AMS) interventions including: antibiotic guidance, reviews of antibiotic use using audits, education, patient facing materials, and self-assessment, are successful in improving antimicrobial use. We aimed to measure the self-reported AMS activity of staff completing a self-assessment tool (SAT). The Royal College of General Practitioners (RCGP)/Public Health England (PHE) SAT enables participants considering an AMS eLearning course to answer 12 short questions about their AMS activities...
August 16, 2017: Antibiotics
https://www.readbyqxmd.com/read/28812519/department-of-health-s-public-utterances-reek-of-complacency
#2
(no author information available yet)
Read a news story about a problem afflicting the NHS and invariably there is a quote attributed to a spokesperson from the Department of Health (DH).
August 16, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28806202/alzheimer-s-disease-caregiver-s-health-and-important-resources-next-steps-in-intervention-research
#3
Kharah M Ross, Judith E Carroll
In this issue of Psychosomatic Medicine, Mausbach and colleagues report that Alzheimer's disease (AD) caregivers who engage in more pleasant leisure activities had lower blood pressure over 5 years compared to those who engage in fewer leisure activities. This novel finding suggests that something as simple as taking more walks in the park or more time for reading books could protect the physical health of caregivers. In this editorial, we review possible mechanisms linking pleasant leisure activities with lower blood pressure in caregivers, and discuss potential barriers that prevent caregivers from engaging in pleasant leisure activities...
August 11, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28805806/lung-tumor-exome-files-with-t-cell-receptor-recombinations-a-mouse-model-of-t-cell-infiltrates-reflecting-mutation-burdens
#4
Yaping N Tu, Wei Lue Tong, Timothy J Fawcett, George Blanck
Tumor exomes and RNASeq data were originally intended for obtaining tumor mutations and gene expression profiles, respectively. However, recent work has determined that tumor exome and RNAseq read files contain reads representing T-cell and B-cell receptor (TcR and BcR) recombinations, presumably due to infiltrating lymphocytes. Furthermore, the recovery of immune receptor recombination reads has demonstrated correlations with specific, previously appreciated aspects of tumor immunology. To further understand the usefulness of recovering TcR and BcR recombinations from tumor exome files, we developed a scripted algorithm for recovery of reads representing these recombinations from a previously described mouse model of lung tumorigenesis...
August 14, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28805805/whole-tumor-section-quantitative-image-analysis-maximizes-between-pathologists-reproducibility-for-clinical-immunohistochemistry-based-biomarkers
#5
Michael Barnes, Chukka Srinivas, Isaac Bai, Judith Frederick, Wendy Liu, Anindya Sarkar, Xiuzhong Wang, Yao Nie, Bryce Portier, Monesh Kapadia, Olcay Sertel, Elizabeth Little, Bikash Sabata, Jim Ranger-Moore
Pathologists have had increasing responsibility for quantitating immunohistochemistry (IHC) biomarkers with the expectation of high between-reader reproducibility due to clinical decision-making especially for patient therapy. Digital imaging-based quantitation of IHC clinical slides offers a potential aid for improvement; however, its clinical adoption is limited potentially due to a conventional field-of-view annotation approach. In this study, we implemented a novel solely morphology-based whole tumor section annotation strategy to maximize image analysis quantitation results between readers...
August 14, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28803131/do-continuum-beliefs-reduce-schizophrenia-stigma-effects-of-a-laboratory-intervention-on-behavioral-and-self-reported-stigma
#6
Ryan Thibodeau, Lindsay N Shanks, Brian P Smith
BACKGROUND AND OBJECTIVES: Correlational research shows that belief in a continuum of psychiatric problems predicts decreased public stigma. However, the correlational findings fail to inform the stigma reduction prospects of manipulating continuum beliefs. All extant experimental work has been executed online. This study examined effects of a laboratory-based continuum intervention on behavioral and self-report measures of psychiatric stigma. METHODS: Sixty-nine undergraduates believed that they would meet a man with schizophrenia...
August 5, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/28801439/validation-of-asthma-recording-in-the-clinical-practice-research-datalink-cprd
#7
Francis Nissen, Daniel R Morales, Hana Mullerova, Liam Smeeth, Ian J Douglas, Jennifer K Quint
OBJECTIVES: The optimal method of identifying people with asthma from electronic health records in primary care is not known. The aim of this study is to determine the positive predictive value (PPV) of different algorithms using clinical codes and prescription data to identify people with asthma in the United Kingdom Clinical Practice Research Datalink (CPRD). METHODS: 684 participants registered with a general practitioner (GP) practice contributing to CPRD between 1 December 2013 and 30 November 2015 were selected according to one of eight predefined potential asthma identification algorithms...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28800158/using-kbase-to-assemble-and-annotate-prokaryotic-genomes
#8
Benjamin Allen, Meghan Drake, Nomi Harris, Tarah Sullivan
The DOE Systems Biology Knowledgebase (KBase, http://kbase.us/) is an open-access bioinformatics software and data platform for analyzing plants, microbes, and their communities. KBase enables scientists to create, execute, collaborate on, and share reproducible analyses of their biological data in the context of public data and private collaborator data. For microbiologists researching prokaryotes, KBase offers analysis tools for performing quality control and assessment of Next-Generation Sequencing reads, de novo assembly, genome annotation, and tools for analyzing structural and functional features of genomes...
August 11, 2017: Current Protocols in Microbiology
https://www.readbyqxmd.com/read/28798667/the-foxp2-driven-network-in-developmental-disorders-and-neurodegeneration
#9
Franz Oswald, Patricia Klöble, André Ruland, David Rosenkranz, Bastian Hinz, Falk Butter, Sanja Ramljak, Ulrich Zechner, Holger Herlyn
The transcription repressor FOXP2 is a crucial player in nervous system evolution and development of humans and songbirds. In order to provide an additional insight into its functional role we compared target gene expression levels between human neuroblastoma cells (SH-SY5Y) stably overexpressing FOXP2 cDNA of either humans or the common chimpanzee, Rhesus monkey, and marmoset, respectively. RNA-seq led to identification of 27 genes with differential regulation under the control of human FOXP2, which were previously reported to have FOXP2-driven and/or songbird song-related expression regulation...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28795413/nursing-lives-in-the-blogosphere-a-thematic-analysis-of-anonymous-online-nursing-narratives
#10
Aimee Castro, Gavin Andrews
AIM: To explore the work-life narratives of nurses through a thematic analysis of the nursing accounts they post in their publicly accessible, anonymous blogs. BACKGROUND: Many nurses participate on social media. Blogs have been advocated as a self-reflective tool in nursing practice, yet as far as the authors are aware, no previous studies have explored nurses' individual blogs for their potential to reveal nurses' perceptions of nursing work. DESIGN: The research design was qualitative description...
August 10, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28792368/streptomyces-phaeopurpureus-shinobu-1957-approved-lists-1980-and-streptomyces-griseorubiginosus-ryabova-and-preobrazhenskaya-1957-pridham-et-al-1958-approved-lists-1980-are-heterotypic-subjective-synonyms
#11
Peter Kämpfer, Christian Rückert, Jochen Blom, Alexander Goesmann, Joachim Wink, Jörn Kalinowski, Stefanie P Glaeser
On the basis of whole genome comparisons of Streptomyces griseorubiginosus and Streptomyces phaeopurpureus it could by shown that these two species are subjective synonyms. The names of both species have been published in the Approved Lists of Bacterial Names and, in such a case, normally Rule 24b (1) of the Prokaryotic Code applies, which reads: 'If two names compete for priority and if both names date from 1 January 1980 on an Approved List, the priority shall be determined by the date of the original publication of the name before 1 January 1980'...
August 10, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28789639/cipher-a-flexible-and-extensive-workflow-platform-for-integrative-next-generation-sequencing-data-analysis-and-genomic-regulatory-element-prediction
#12
Carlos Guzman, Iván D'Orso
BACKGROUND: Next-generation sequencing (NGS) approaches are commonly used to identify key regulatory networks that drive transcriptional programs. Although these technologies are frequently used in biological studies, NGS data analysis remains a challenging, time-consuming, and often irreproducible process. Therefore, there is a need for a comprehensive and flexible workflow platform that can accelerate data processing and analysis so more time can be spent on functional studies. RESULTS: We have developed an integrative, stand-alone workflow platform, named CIPHER, for the systematic analysis of several commonly used NGS datasets including ChIP-seq, RNA-seq, MNase-seq, DNase-seq, GRO-seq, and ATAC-seq data...
August 8, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28780144/report-on-the-midwives-experiences-in-the-brazilian-national-health-system-a-qualitative-research
#13
Nádia Zanon Narchi, Cláudia Medeiros de Castro, Cintia de Freitas Oliveira, Fernanda Tambellini
OBJECTIVE: to describe the experiences of midwives who graduated from the University of São Paulo's midwifery program and the characteristics of their work within the Brazilian National Health System (SUS). DESIGN: a descriptive, qualitative field study. SETTING: interviews were scheduled by telephone or e-mail and were held with the midwives outside their work environment. Interviews lasted for up to one hour and were recorded. PARTICIPANTS: ten midwives who had graduated from the University of São Paulo's midwifery program and were working or had worked in the SUS at the time of the study...
July 20, 2017: Midwifery
https://www.readbyqxmd.com/read/28771471/the-genomic-observatories-metadatabase-geome-a-new-repository-for-field-and-sampling-event-metadata-associated-with-genetic-samples
#14
John Deck, Michelle R Gaither, Rodney Ewing, Christopher E Bird, Neil Davies, Christopher Meyer, Cynthia Riginos, Robert J Toonen, Eric D Crandall
The Genomic Observatories Metadatabase (GeOMe, http://www.geome-db.org/) is an open access repository for geographic and ecological metadata associated with biosamples and genetic data. Whereas public databases have served as vital repositories for nucleotide sequences, they do not accession all the metadata required for ecological or evolutionary analyses. GeOMe fills this need, providing a user-friendly, web-based interface for both data contributors and data recipients. The interface allows data contributors to create a customized yet standard-compliant spreadsheet that captures the temporal and geospatial context of each biosample...
August 2017: PLoS Biology
https://www.readbyqxmd.com/read/28771221/childhood-outcomes-following-preterm-prelabor-rupture-of-the-membranes-pprom-a-population-based-record-linkage-cohort-study
#15
C L Roberts, P Wagland, S Torvaldsen, J R Bowen, J P Bentley, J M Morris
OBJECTIVE: The objective of this study is to determine child health, development and educational outcomes for infants born following preterm prelabor rupture of the membrane (PPROM). STUDY DESIGN: Population-based record linkage cohort study using data from NSW, Australia, 2001 to 2014. RESULTS: Of 121 822 births at 20 to 37 weeks, 18 799 (15%) followed PPROM, 56 406 (46%) followed spontaneous labor and 46 617 (38%) were planned. Compared with infants of a similar gestational age born following spontaneous labor or planned delivery, exposure to PPROM did not increase the risk of childhood mortality, childhood hospitalization, developmentally vulnerable at school entry, low reading or numeracy scores...
August 3, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28770026/neisseria-lactamica-y92-1009-complete-genome-sequence
#16
Anish K Pandey, David W Cleary, Jay R Laver, Martin C J Maiden, Xavier Didelot, Andrew Gorringe, Robert C Read
We present the high quality, complete genome assembly of Neisseria lactamica Y92-1009 used to manufacture an outer membrane vesicle (OMV)-based vaccine, and a member of the Neisseria genus. The strain is available on request from the Public Health England Meningococcal Reference Unit. This Gram negative, dipplococcoid bacterium is an organism of worldwide clinical interest because human nasopharyngeal carriage is related inversely to the incidence of meningococcal disease, caused by Neisseria meningitidis. The organism sequenced was isolated during a school carriage survey in Northern Ireland in 1992 and has been the subject of a variety of laboratory and clinical studies...
2017: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/28768114/essential-literature-for-the-chiropractic-profession-results-and-implementation-challenges-from-a-survey-of-international-chiropractic-faculty
#17
Barbara A Mansholt, Stacie A Salsbury, Lance G Corber, John S Stites
OBJECTIVE: Scientific literature applicable to chiropractic practice proliferates in quantity, quality, and source. Chiropractic is a worldwide profession and varies in scope between states or provinces and from country to country. It is logical to consider that the focus and emphasis of chiropractic education varies between programs as well. This original research study endeavored to determine "essential literature" recommended by chiropractic faculty. The purpose of this article is (1) to share our results and (2) to promote discussion and explore means for future collaboration of chiropractic faculty through a worldwide platform...
August 2, 2017: Journal of Chiropractic Education
https://www.readbyqxmd.com/read/28767924/elderly-with-knee-osteoarthritis-should-perform-nutritional-assessment-integrative-literature-review
#18
Isabelle Ferreira da Silva Souza, Rosa Sá de Oliveira Neta, Juliana Maria Gazzola, Marcelo Cardoso de Souza
To review scientific literature to assess nutritional status of elderly patients with osteoarthritis in the last 16 years. This is an integrative literature review that included articles published in national and international journals indexed in PubMed, SciELO and BIREME. We selected 14 articles, and English language was predominant. The year of publication of articles ranged from 2006 to 2016, and most of papers were cross-sectional studies. To gather papers and for posterior evaluate, we used a validated data collection instrument and the included studies were critical analyzed by reading, gathering and analysis of articles...
April 2017: Einstein
https://www.readbyqxmd.com/read/28762882/acute-pesticide-related-illness-among-farmworkers-barriers-to-reporting-to-public-health-authorities
#19
Joanne Bonnar Prado, Prakash R Mulay, Edward J Kasner, Heidi K Bojes, Geoffrey M Calvert
Farmworkers are at high risk of acute occupational pesticide-related illness (AOPI) and AOPI surveillance is vital to preventing these illnesses. Data on such illnesses are collected and analyzed to identify high risk groups, high risk pesticides, and root causes. Interventions to address these risks and root causes include farmworker outreach, education, and regulation. Unfortunately, it is well known that AOPI is under-reported, meaning that the true burden of this condition remains unknown. This paper reviews the barriers to reporting of farmworker AOPI to public health authorities and provides some practical solutions...
August 1, 2017: Journal of Agromedicine
https://www.readbyqxmd.com/read/28759564/de-novo-assembly-and-annotation-of-the-retinal-transcriptome-for-the-nile-grass-rat-arvicanthis-ansorgei
#20
Melissa M Liu, Michael Farkas, Perrine Spinnhirny, Paul Pevet, Eric Pierce, David Hicks, Donald J Zack
Cone photoreceptors are required for color vision and high acuity vision, and they die in a variety of retinal degenerations, leading to irreversible vision loss and reduced quality of life. To date, there are no approved therapies that promote the health and survival of cones. The development of novel treatments targeting cones has been challenging and impeded, in part, by the limitations inherent in using common rodent model organisms, which are nocturnal and rod-dominant, to study cone biology. The African Nile grass rat (Arvicanthis ansorgei), a diurnal animal whose photoreceptor population is more than 30% cones, offers significant potential as a model organism for the study of cone development, biology, and degeneration...
2017: PloS One
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