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https://www.readbyqxmd.com/read/29452110/exploring-the-impact-of-house-screening-intervention-on-entomological-indices-and-incidence-of-malaria-in-arba-minch-town-southwest-ethiopia-a-randomized-control-trial
#1
Solomon Kinde Getawen, Temesgen Ashine, Fekadu Massebo, Daniel Woldeyes, Bernt Lindtjørn
House is the major site for malaria infection where most human-vector contact takes place. Hence, improving housing might reduce the risk of malaria infection by limiting house entry of vectors. This study aimed to explore the impact of screening doors and windows with wire meshes on density and entomological inoculation rate (EIR) of malaria vector, and malaria incidence, and assess the acceptability, durability, and cost of the intervention. The susceptibility status of malaria vector was also assessed. A two-arm randomized trial was done in Arba Minch Town, southwest Ethiopia...
February 13, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29448936/chitinase-3-like-1-is-a-biomarker-of-acute-kidney-injury-and-mortality-in-paediatric-severe-malaria
#2
Andrea L Conroy, Michael T Hawkes, Robyn Elphinstone, Robert O Opoka, Sophie Namasopo, Christopher Miller, Chandy C John, Kevin C Kain
BACKGROUND: Chitinase-3-like 1 (CHI3L1) is a glycoprotein elevated in paediatric severe malaria, and an emerging urinary biomarker of acute kidney injury (AKI). Based on the hypothesis that elevated CHI3L1 levels in malaria are associated with disease severity, the relationship between plasma CHI3L1 levels, AKI and mortality was investigated in Ugandan children enrolled in a clinical trial evaluating inhaled nitric oxide (iNO) as an adjunctive therapy for severe malaria. METHODS: Plasma CHI3L1 levels were measured daily for 4 days in children admitted to hospital with severe malaria and at day 14 follow up...
February 15, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29435408/a-putative-rna-binding-protein-from-plasmodium-vivax-apicoplast
#3
Sofía M García-Mauriño, Antonio Díaz-Quintana, Francisco Rivero-Rodríguez, Isabel Cruz-Gallardo, Christian Grüttner, Marian Hernández-Vellisca, Irene Díaz-Moreno
Malaria is caused by Apicomplexa protozoans from the Plasmodium genus entering the bloodstream of humans and animals through the bite of the female mosquitoes. The annotation of the Plasmodium vivax genome revealed a putative RNA binding protein (apiRBP) that was predicted to be trafficked into the apicoplast, a plastid organelle unique to Apicomplexa protozoans. Although a 3D structural model of the apiRBP corresponds to a noncanonical RNA recognition motif with an additional C-terminal α-helix (α3), preliminary protein production trials were nevertheless unsuccessful...
February 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29432383/safety-and-immunogenicity-of-seven-dosing-regimens-of-the-candidate-rts-s-as01e-malaria-vaccine-integrated-within-an-expanded-program-on-immunization-regimen-a-phase-ii-single-center-open-controlled-trial-in-infants-in-malawi
#4
Desiree Witte, Nigel A Cunliffe, Ann M Turner, Edward Ngulube, Opokua Ofori-Anyinam, Johan Vekemans, Philips Chimpeni, Marc Lievens, Trevor P Wilson, Jenala Njiramʼmadzi, Yolanda Guerra Mendoza, Amanda Leach
BACKGROUND: In a phase III trial, the RTS,S/AS01 malaria vaccine produced lower anti-circumsporozoite (CS) antibody titres when co-administered with Expanded Programme on Immunisation (EPI) vaccines (0,1,2-month schedule) at 6-12 weeks compared to 5-17 months at first vaccination. Alternative infant immunisation schedules within the EPI were investigated. METHODS: This phase II, open, single site (Blantyre, Malawi) trial was conducted in infants aged 1-7 days. Subjects were equally randomised across seven groups to receive three doses of RTS,S/AS01E at time points that included ≤7 days, 6, 10, 14, 26 weeks, and 9 months...
February 9, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29422423/use-of-artesunate-in-non-malarial-indications
#5
REVIEW
A Raffetin, F Bruneel, C Roussel, M Thellier, P Buffet, E Caumes, S Jauréguiberry
INTRODUCTION: Artesunate and other artemisinin derivatives are used in various infectious and non-infectious diseases. We aimed to analyze available data on artesunate and artemisinin derivatives activity in humans and their potential clinical benefits in non-malarial indications. MATERIAL AND METHODS: Literature review performed on PubMed and the Cochrane Library databases using the PRISMA method. We analyzed studies published in English from January 2008 to August 2017 using the same indicators of drug efficacy...
February 5, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29422384/efficacy-and-safety-of-primaquine-and-methylene-blue-for-prevention-of-plasmodium-falciparum-transmission-in-mali-a-phase-2-single-blind-randomised-controlled-trial
#6
Alassane Dicko, Michelle E Roh, Halimatou Diawara, Almahamoudou Mahamar, Harouna M Soumare, Kjerstin Lanke, John Bradley, Koualy Sanogo, Daouda T Kone, Kalifa Diarra, Sekouba Keita, Djibrilla Issiaka, Sekou F Traore, Charles McCulloch, Will J R Stone, Jimee Hwang, Olaf Müller, Joelle M Brown, Vinay Srinivasan, Chris Drakeley, Roly Gosling, Ingrid Chen, Teun Bousema
BACKGROUND: Primaquine and methylene blue are gametocytocidal compounds that could prevent Plasmodium falciparum transmission to mosquitoes. We aimed to assess the efficacy and safety of primaquine and methylene blue in preventing human to mosquito transmission of P falciparum among glucose-6-phosphate dehydrogenase (G6PD)-normal, gametocytaemic male participants. METHODS: This was a phase 2, single-blind, randomised controlled trial done at the Clinical Research Centre of the Malaria Research and Training Centre (MRTC) of the University of Bamako (Bamako, Mali)...
February 5, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29422151/interdisciplinary-ugandan-perspectives-on-computerized-intervention-implementation-for-child-survivors-of-severe-malaria-a-qualitative-analysis
#7
Katherine Finn, Jody Lori, Maurgan Lee, Bruno Giordani
PURPOSE: Severe malaria (SM) is the leading cause of pediatric cognitive impairment in sub-Saharan Africa. Computerized Cognitive Rehabilitation Therapy (CCRT), a promising intervention for children suffering from SM related cognitive delay, targets areas impacted by the disease (memory, attention, and executive function), but has yet to be implemented for daily use. This paper explores the perspectives of Ugandan professionals regarding CCRT implementation in the academic setting of Uganda...
February 2018: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29415730/effect-of-nutrient-supplementation-on-the-acquisition-of-humoral-immunity-to-plasmodium-falciparum-in-young-malawian-children
#8
Priyanka Barua, Upeksha P Chandrasiri, James G Beeson, Kathryn G Dewey, Kenneth Maleta, Per Ashorn, Stephen J Rogerson
BACKGROUND: There is evidence that suggests that undernutrition has a detrimental effect on malarial immunity in children. The aim of the study was to discover whether nutrient supplementation improved development of malarial antibody immunity in children up to 18 months of age. METHODS: The study was conducted with a subset of 432 Malawian children from a randomized controlled trial of nutritional supplements. The arms included pre- and postnatal small-quantity lipid-based nutrient supplements for both mother and child; prenatal supplementation with iron and folic acid; and pre- and postnatal supplementation with multiple micronutrients...
February 7, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29409511/a-qualitative-study-of-use-of-long-lasting-insecticidal-nets-llins-for-intended-and-unintended-purposes-in-adami-tullu-east-shewa-zone-ethiopia
#9
Zerihun Doda, Tarekegn Solomon, Eskindir Loha, Taye Gari, Bernt Lindtjørn
BACKGROUND: Malaria poses a significant public health threat globally, across Africa and in Ethiopia. The use of long-lasting insecticidal nets (LLINs) is currently a proven prevention mechanism. Evidence is building on what happens to LLINs following mass distribution campaigns, with mixed results from different studies, some reporting very low use for intended purposes, others an encouraging level of using for intended purposes. In Ethiopia, between 2005 and 2015, about 64 million LLINs were distributed through periodic mass campaigns with the aims to achieve 100% coverage and 80% utilization...
February 6, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29405263/mosquito-repellents-for-malaria-prevention
#10
REVIEW
Marta F Maia, Merav Kliner, Marty Richardson, Christian Lengeler, Sarah J Moore
BACKGROUND: Malaria is an important cause of illness and death across endemic regions. Considerable success against malaria has been achieved within the past decade mainly through long-lasting insecticide-treated nets (LLINs). However, elimination of the disease is proving difficult as current control methods do not protect against mosquitoes biting outdoors and when people are active. Repellents may provide a personal protection solution during these times. OBJECTIVES: To assess the impact of topical repellents, insecticide-treated clothing, and spatial repellents on malaria transmission...
February 6, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29397427/poly-i-c-adjuvant-strongly-enhances-parasite-inhibitory-antibodies-and-th1-response-against-plasmodium-falciparum-merozoite-surface-protein-1-42-kda-fragment-in-balb-c-mice
#11
Akram Abouie Mehrizi, Niloufar Rezvani, Sedigheh Zakeri, Atefeh Gholami, Laleh Babaeekhou
Malaria vaccine development has been confronted with various challenges such as poor immunogenicity of malaria vaccine candidate antigens, which is considered as the main challenge. However, this problem can be managed using appropriate formulations of antigens and adjuvants. Poly(I:C) is a potent Th1 inducer and a human compatible adjuvant capable of stimulating both B- and T-cell immunity. Plasmodium falciparum merozoite surface protein 142 (PfMSP-142) is a promising vaccine candidate for blood stage of malaria that has faced several difficulties in clinical trials, mainly due to improper adjuvants...
February 3, 2018: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/29396010/burden-pathology-and-costs-of-malaria-in-pregnancy-new-developments-for-an-old-problem
#12
REVIEW
Stephen J Rogerson, Meghna Desai, Alfredo Mayor, Elisa Sicuri, Steve M Taylor, Anna M van Eijk
Over the past 10 years, knowledge of the burden, economic costs, and consequences of malaria in pregnancy has improved, and the prevalence of malaria caused by Plasmodium falciparum has declined substantially in some geographical areas. In particular, studies outside of Africa have increased the evidence base of Plasmodium vivax in pregnancy. Rapid diagnostic tests have been poor at detecting malaria in pregnant women, while PCR has shown a high prevalence of low density infection, the clinical importance of which is unknown...
January 30, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29395998/treatment-of-uncomplicated-and-severe-malaria-during-pregnancy
#13
REVIEW
Umberto D'Alessandro, Jenny Hill, Joel Tarning, Christopher Pell, Jayne Webster, Julie Gutman, Esperanca Sevene
Over the past 10 years, the available evidence on the treatment of malaria during pregnancy has increased substantially. Owing to their relative ease of use, good sensitivity and specificity, histidine rich protein 2 based rapid diagnostic tests are appropriate for symptomatic pregnant women; however, such tests are less appropriate for systematic screening because they will not detect an important proportion of infections among asymptomatic women. The effect of pregnancy on the pharmacokinetics of antimalarial drugs varies greatly between studies and class of antimalarial drugs, emphasising the need for prospective studies in pregnant and non-pregnant women...
January 30, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29395997/prevention-of-malaria-in-pregnancy
#14
REVIEW
Meghna Desai, Jenny Hill, Silke Fernandes, Patrick Walker, Christopher Pell, Julie Gutman, Kassoum Kayentao, Raquel Gonzalez, Jayne Webster, Brian Greenwood, Michel Cot, Feiko O Ter Kuile
Malaria remains one of the most preventable causes of adverse birth outcomes. Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine is used to prevent malaria, but resistance to this drug combination has decreased its efficacy and new alternatives are needed. In Africa, a meta-analysis showed three-course or monthly IPTp with sulfadoxine-pyrimethamine to be safe and more effective than the original two-course sulfadoxine-pyrimethamine strategy, prompting WHO to update its policy in 2012...
January 30, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29393511/primaquine-or-other-8-aminoquinolines-for-reducing-plasmodium-falciparum-transmission
#15
REVIEW
Patricia M Graves, Leslie Choi, Hellen Gelband, Paul Garner
BACKGROUND: The 8-aminoquinoline (8AQ) drugs act on Plasmodium falciparum gametocytes, which transmit malaria from infected people to mosquitoes. In 2012, the World Health Organization (WHO) recommended a single dose of 0.25 mg/kg primaquine (PQ) be added to malaria treatment schedules in low-transmission areas or those with artemisinin resistance. This replaced the previous recommendation of 0.75 mg/kg, aiming to reduce haemolysis risk in people with glucose-6-phosphate dehydrogenase deficiency, common in people living in malarious areas...
February 2, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29390014/impact-of-treatment-and-re-treatment-with-artemether-lumefantrine-and-artesunate-amodiaquine-on-selection-of-plasmodium-falciparum-multidrug-resistance-gene-1-polymorphisms-in-the-democratic-republic-of-congo-and-uganda
#16
Vito Baraka, Hypolite Muhindo Mavoko, Carolyn Nabasumba, Filbert Francis, Pascal Lutumba, Michael Alifrangis, Jean-Pierre Van Geertruyden
BACKGROUND: The emergence of resistance against artemisinin combination treatment is a major concern for malaria control. ACTs are recommended as the rescue treatment, however, there is limited evidence as to whether treatment and re-treatment with ACTs select for drug-resistant P. falciparum parasites. Thus, the purpose of the present study is to investigate the impact of (re-)treatment using artesunate-amodiaquine (ASAQ) and artemether-lumefantrine (AL) on the selection of P. falciparum multidrug resistance-1 (Pfmdr1) alleles in clinical settings...
2018: PloS One
https://www.readbyqxmd.com/read/29389958/a-mobile-health-technology-platform-for-quality-assurance-and-quality-improvement-of-malaria-diagnosis-by-community-health-workers
#17
Jeremiah Laktabai, Alyssa Platt, Diana Menya, Elizabeth L Turner, Daniel Aswa, Stephen Kinoti, Wendy Prudhomme O'Meara
BACKGROUND: Community health workers (CHWs) play an important role in improving access to services in areas with limited health infrastructure or workforce. Supervision of CHWs by qualified health professionals is the main link between this lay workforce and the formal health system. The quality of services provided by lay health workers is dependent on adequate supportive supervision. It is however one of the weakest links in CHW programs due to logistical and resource constraints, especially in large scale programs...
2018: PloS One
https://www.readbyqxmd.com/read/29389541/association-of-the-paediatric-admission-quality-of-care-score-with-mortality-in-kenyan-hospitals-a-validation-study
#18
Charles Opondo, Elizabeth Allen, Jim Todd, Mike English
BACKGROUND: Measuring the quality of hospital admission care is essential to ensure that standards of practice are met and continuously improved to reduce morbidity and mortality associated with the illnesses most responsible for inpatient deaths. The Paediatric Admission Quality of Care (PAQC) score is a tool for measuring adherence to guidelines for children admitted with acute illnesses in a low-income setting. We aimed to explore the external and criterion-related validity of the PAQC score by investigating its association with mortality using data drawn from a diverse sample of Kenyan hospitals...
February 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29386156/a-randomized-control-and-comparative-study-of-polyherbal-formulation-use-for-malaria-plasmodium-falciparum
#19
Khan Muhammad Baloch, Khan Usmanghani, Ejaz Mohiuddin, Tasneem Qureshi, Muhammad Daniyal, Muhammad Ibrar Shinwari
Plasmodium falciparum is the most well-known reason for extreme and life-debilitating malaria. Falciparum malaria causes more than 1 million deaths annually. Malaria remains a noteworthy reason for major morbidity and mortality in the tropics, with Plasmodium falciparum accountable for the mainstream of the disease weight and Plasmodium vivax being the geologically greatest broadly dispersed cause of malaria. The controlling of severe malaria comprises quick direction of suitable parenteral anti-malarial agents and initial acknowledgement and treatment of the complications...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29382292/interpreting-challenge-data-from-early-phase-malaria-blood-stage-vaccine-trials
#20
Michael F Good, Louis H Miller
Introduction As the quest for an effective blood stage malaria vaccine continues, there is increasing reliance on the use of controlled human malaria infections (CHMI) in non-endemic settings to test vaccine efficacy at the earliest possible time. This is seen as a way to accelerate vaccine research and quickly eliminate candidates with poor efficacy. Areas covered The data from these studies need to be carefully examined and interpreted in light of the very different roles that antibody and cellular immunity play in protection and within the context of the distinct clinical sensitivities of volunteers living in malaria-non-endemic countries compared to those living in endemic countries...
January 30, 2018: Expert Review of Vaccines
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