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Thornton, C

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https://www.readbyqxmd.com/read/28425465/chytrid-fungus-infection-in-zebrafish-demonstrates-that-the-pathogen-can-parasitize-non-amphibian-vertebrate-hosts
#1
Nicole Liew, Maria J Mazon Moya, Claudia J Wierzbicki, Michael Hollinshead, Michael J Dillon, Christopher R Thornton, Amy Ellison, Jo Cable, Matthew C Fisher, Serge Mostowy
Aquatic chytrid fungi threaten amphibian biodiversity worldwide owing to their ability to rapidly expand their geographical distributions and to infect a wide range of hosts. Combating this risk requires an understanding of chytrid host range to identify potential reservoirs of infection and to safeguard uninfected regions through enhanced biosecurity. Here we extend our knowledge on the host range of the chytrid Batrachochytrium dendrobatidis by demonstrating infection of a non-amphibian vertebrate host, the zebrafish...
April 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28407971/effect-of-phytosanitary-irradiation-on-the-postharvest-quality-of-seedless-kishu-mandarins-citrus-kinokuni-mukakukishu
#2
José de Jesús Ornelas-Paz, María Belén Meza, David Obenland, Karina Rodríguez Friscia, Akanksha Jain, Shantaè Thornton, Anuradha Prakash
Transnational trade of 'Seedless Kishu' mandarins (Citrus kinokuni mukakukishu) would require them to be subjected to a suitable phytosanitary treatment. Irradiation is used as an effective treatment for many fruit, but the effect on quality of kishu mandarins is unknown. 'Seedless Kishu' mandarins were treated with gamma irradiation (150, 400, and 1000Gy) and stored for three weeks at 6°C and then for one week at 20°C. Irradiation at 400 and 1000Gy promoted browning of the calyx end and fungal infection...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28403411/comparison-of-bioreactance-and-echocardiographic-non-invasive-cardiac-output-monitoring-and-myocardial-function-assessment-in-primagravida-women
#3
A Doherty, A El-Khuffash, C Monteith, L McSweeney, C Breatnach, E Kent, E Tully, F Malone, P Thornton
Background.: Non-invasive cardiac output monitoring (NICOM) using bioreactance (BRT) in pregnancy is gaining interest but lacks validation. We compared simultaneous cardiac output (CO) measurements obtained using the NICOM ® (BRT-CO) and echocardiography (echo-CO), and assessed the relationship between maternal characteristics and myocardial performance. Methods.: Paired stroke volume (SV) and CO readings were obtained using NICOM ® and echocardiography, in a group of healthy nulliparous women throughout a 15 min period...
April 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28402971/implicating-receptor-activator-of-nf-%C3%AE%C2%BAb-rank-rank-ligand-signalling-in-microglial-responses-to-toll-like-receptor-stimuli
#4
Anton Kichev, Pascale Eede, Pierre Gressens, Claire Thornton, Henrik Hagberg
Inflammation in the perinatal brain caused by maternal or intrauterine fetal infection is now well established as an important contributor to the development of perinatal brain injury. Exposure to inflammatory products can impair perinatal brain development and act as a risk factor for neurological dysfunction, cognitive disorders, cerebral palsy, or preterm birth. Pre-exposure to inflammation significantly exacerbates brain injury caused by hypoxic/ischaemic insult. Tumour necrosis factor (TNF) is a family of cytokines largely involved in inflammation signalling...
April 13, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28400740/c-command-in-the-grammars-of-children-with-high-functioning-autism
#5
Neha Khetrapal, Rosalind Thornton
A recent study questioned the adherence of children with Autism Spectrum Disorders (ASD) to a linguistic constraint on the use of reflexive pronouns (Principle A) in sentences like Bart's dad is touching himself. This led researchers to question whether children with ASD are able to compute the hierarchical structural relationship of c-command, and raised the possibility that the children rely on a linear strategy for reference assignment. The current study investigates the status of c-command in children with ASD by testing their interpretation of sentences like (1) and (2) that tease apart use of c-command and a linear strategy for reference assignment...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28394895/larval-crowding-accelerates-c-elegans-development-and-reduces-lifespan
#6
Andreas H Ludewig, Clotilde Gimond, Joshua C Judkins, Staci Thornton, Dania C Pulido, Robert J Micikas, Frank Döring, Adam Antebi, Christian Braendle, Frank C Schroeder
Environmental conditions experienced during animal development are thought to have sustained impact on maturation and adult lifespan. Here we show that in the model organism C. elegans developmental rate and adult lifespan depend on larval population density, and that this effect is mediated by excreted small molecules. By using the time point of first egg laying as a marker for full maturity, we found that wildtype hermaphrodites raised under high density conditions developed significantly faster than animals raised in isolation...
April 10, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28393661/persistence-of-macrocytosis-after-discontinuation-of-zidovudine-in-hiv-infected-patients
#7
Inski Yu, Richard N Greenberg, Timothy N Crawford, Alice C Thornton, Thein Myint
The duration of macrocytosis after stopping zidovudine (ZDV) is unknown. Among 104 HIV-infected patients treated with ZDV for more than 1 year, 84 patients had macrocytosis at ZDV discontinuation. The median mean corpuscular volume (MCV) was 114.6 fL (range 100-128 fL). Patients were divided into 2 groups: those who did (resolved macrocytosis, n = 36) and did not (persistent macrocytosis, n = 48) normalize MCV at 3 to 6 months after ZDV discontinuation. Alcohol use ( P = .02), smoking ( P = .03), and lower (but within normal range) folic acid levels ( P = ...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28384381/nurses-experiences-with-patients-who-die-from-failure-to-rescue-after-surgery
#8
Cynthia Thornton Bacon
PURPOSE: To describe the lived experiences of hospital nurses caring for surgical patients who died from failure to rescue (FTR). DESIGN: A qualitative phenomenologic approach was used. Methods to ensure rigor and trustworthiness were incorporated into the design. METHODS: The investigator conducted one-on-one semistructured interviews with 14 nurses, and data were analyzed using Colaizzi's methods. FINDINGS: Six themes were identified: (a) the environment surrounding the FTR was unexpected; (b) FTR was unexpected but not preventable; (c) nurses were emotionally ill-prepared for the FTR; (d) nurse outcomes are different in unexpected versus expected death; (e) nurses' roles as protectors are important; and (f) FTR effects future nursing practice...
April 6, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28378620/the-anorexia-nervosa-genetics-initiative-study-description-and-sample-characteristics-of-the-australian-and-new-zealand-arm
#9
Katherine M Kirk, Felicity C Martin, Amy Mao, Richard Parker, Sarah Maguire, Laura M Thornton, Gu Zhu, Kerrie McAloney, Jeremy L Freeman, Phillipa Hay, Sloane Madden, Christine Morgan, Janice Russell, Susan M Sawyer, Elizabeth K Hughes, A Kate Fairweather-Schmidt, Anthea Fursland, Julie McCormack, Fiona Wagg, Jennifer Jordan, Martin A Kennedy, Warren Ward, Tracey D Wade, Cynthia M Bulik, Nicholas G Martin
OBJECTIVES: Anorexia nervosa is a severe psychiatric disorder with high mortality rates. While its aetiology is poorly understood, there is evidence of a significant genetic component. The Anorexia Nervosa Genetics Initiative is an international collaboration which aims to understand the genetic basis of the disorder. This paper describes the recruitment and characteristics of the Australasian Anorexia Nervosa Genetics Initiative sample, the largest sample of individuals with anorexia nervosa ever assembled across Australia and New Zealand...
April 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28371853/patient-portals-and-broadband-internet-inequality
#10
Adam T Perzynski, Mary Joan Roach, Sarah Shick, Bill Callahan, Douglas Gunzler, Randall Cebul, David C Kaelber, Anne Huml, John Daryl Thornton, Douglas Einstadter
Background: Patient portals have shown potential for increasing health care quality and efficiency. Internet access and other factors influencing patient portal use could worsen health disparities. Methods: Observational study of adults with 1 or more visits to the outpatient clinics of an urban public health care system from 2012 to 2015. We used mixed effects logistic regression to evaluate the association between broadband internet access and (1) patient portal initiation (whether a patient logged in at least 1 time) and (2) messaging, controlling for demographic and neighborhood characteristics...
March 23, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28334935/genome-wide-association-study-of-iron-traits-and-relation-to-diabetes-in-the-hispanic-community-health-study-study-of-latinos-hchs-sol-potential-genomic-intersection-of-iron-and-glucose-regulation
#11
Laura M Raffield, Tin Louie, Tamar Sofer, Deepti Jain, Eli Ipp, Kent D Taylor, George J Papanicolaou, Larissa Avilés-Santa, Leslie A Lange, Cathy C Laurie, Matthew P Conomos, Timothy A Thornton, Yii-Der Ida Chen, Qibin Qi, Scott Cotler, Bharat Thyagarajan, Neil Schneiderman, Jerome I Rotter, Alex P Reiner, Henry J Lin
Genetic variants contribute to normal variation of iron-related traits and may also cause clinical syndromes of iron deficiency or excess. Iron overload and deficiency can adversely affect human health. For example, elevated iron storage is associated with increased diabetes risk, although mechanisms are still being investigated. We conducted the first genome-wide association study (GWAS) of serum iron, total iron binding capacity (TIBC), transferrin saturation, and ferritin in a Hispanic/Latino cohort, the Hispanic Community Health Study/Study of Latinos (HCHS/SOL; >12,000 participants) and also assessed the generalization of previously known loci to this population...
March 7, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28295207/human-gestation-associated-tissues-express-functional-cytosolic-nucleic-acid-sensing-pattern-recognition-receptors
#12
A H Bryant, G E Menzies, L M Scott, S Spencer-Harty, L B Davies, R A Smith, R H Jones, C A Thornton
The role of viral infections in adverse pregnancy outcomes has gained interest in recent years. Innate immune pattern recognition receptors (PRRs) and their signalling pathways, that yield a cytokine output in response to pathogenic stimuli, have been postulated to link infection at the maternal-fetal interface and adverse pregnancy outcomes. The objective of this study was to investigate the expression and functional response of nucleic acid ligand responsive Toll-like receptors (TLR-3, -7, -8 and -9), and retinoic acid-inducible gene 1 (RIG-I)-like receptors [RIG-I, melanoma differentiation-associated protein 5 (MDA5) and Laboratory of Genetics and Physiology 2(LGP2)] in human term gestation-associated tissues (placenta, choriodecidua and amnion) using an explant model...
March 13, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28282053/the-neodymium-neologism
#13
Brett F Thornton, Shawn C Burdette
No abstract text is available yet for this article.
January 24, 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28281761/formation-of-low-volatility-organic-compounds-in-the-atmosphere-recent-advancements-and-insights
#14
Kelley C Barsanti, Jesse H Kroll, Joel A Thornton
Secondary organic aerosol (SOA) formation proceeds by bimolecular gas-phase oxidation reactions generating species that are sufficiently low in volatility to partition into the condensed phase. Advances in instrumentation have revealed that atmospheric SOA is less volatile and more oxidized than can be explained solely by these well-studied gas-phase oxidation pathways, supporting the role of additional chemical processes. These processes-autoxidation, accretion, and organic salt formation-can lead to exceedingly low-volatility species that recently have been identified in laboratory and field studies...
March 21, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28279936/resilience-theory-incorporated-into-urban-wastewater-systems-management-state-of-the-art
#15
REVIEW
P Juan-García, D Butler, J Comas, G Darch, C Sweetapple, A Thornton, Ll Corominas
Government bodies, utilities, practitioners, and researchers have growing interest in the incorporation of resilience into wastewater management. Since resilience is a multidisciplinary term, it is important to review what has been achieved in the wastewater sector, and describe the future research directions for the forthcoming years. This work presents a critical review of studies that deal with resilience in the wastewater treatment sector, with a special focus on understanding how they addressed the key elements for assessing resilience, such as stressors, system properties, metrics and interventions to increase resilience...
February 20, 2017: Water Research
https://www.readbyqxmd.com/read/28253260/direct-keap1-nrf2-disruption-as-a-potential-therapeutic-target-for-alzheimer-s-disease
#16
Fiona Kerr, Oyinkan Sofola-Adesakin, Dobril K Ivanov, Jemma Gatliff, Beatriz Gomez Perez-Nievas, Hélène C Bertrand, Pedro Martinez, Rebecca Callard, Inge Snoeren, Helena M Cochemé, Jennifer Adcott, Mobina Khericha, Jorge Iván Castillo-Quan, Geoffrey Wells, Wendy Noble, Janet Thornton, Linda Partridge
Nrf2, a transcriptional activator of cell protection genes, is an attractive therapeutic target for the prevention of neurodegenerative diseases, including Alzheimer's disease (AD). Current Nrf2 activators, however, may exert toxicity and pathway over-activation can induce detrimental effects. An understanding of the mechanisms mediating Nrf2 inhibition in neurodegenerative conditions may therefore direct the design of drugs targeted for the prevention of these diseases with minimal side-effects. Our study provides the first in vivo evidence that specific inhibition of Keap1, a negative regulator of Nrf2, can prevent neuronal toxicity in response to the AD-initiating Aβ42 peptide, in correlation with Nrf2 activation...
March 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28245527/isolation-of-mesenchymal-stromal-cells-from-peripheral-blood-of-st-elevation-myocardial-infarction-patients
#17
Ina Laura Pieper, Rachel Smith, Joanna C Bishop, Omar Aldalati, Alex J Chase, Gareth Morgan, Catherine A Thornton
Bone marrow mesenchymal stromal cells (MSCs) have shown therapeutic potential in the treatment of myocardial infarction patients. However, bone marrow requires invasive harvesting techniques. Therefore, the aim was to carry out a feasibility study of using autologous peripheral blood (PB) as a source for MSCs and platelet lysate (PL), a potential novel therapeutic intervention in acute ST elevation myocardial infarction (STEMI) patients. Autologous PL and MSCs were prepared from STEMI patient and healthy control blood...
February 28, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28224043/pleiotropic-effect-of-a-novel-mutation-in-gcnt2-causing-congenital-cataract-and-a-rare-adult-i-blood-group-phenotype
#18
Sek-Shir Cheong, Sarah Hull, Benjamin Jones, Ravinder Chana, Nicole Thornton, Vincent Plagnol, Anthony T Moore, Alison J Hardcastle
Mutations in GCNT2 have been associated with the rare adult i blood group phenotype with or without congenital cataract. We report a novel homozygous frameshift mutation c.1163_1166delATCA, p.(Asn388Argfs*20) as the cause of congenital cataract in two affected siblings. Blood group typing confirmed that both affected males have the rare adult i phenotype, supporting the hypothesis that the partial association of I/i phenotype and congenital cataract is due to the differential expression of GCNT2 isoforms.
2017: Human Genome Variation
https://www.readbyqxmd.com/read/28199798/the-hotel-study-clinical-and-health-service-effectiveness-in-a-cohort-of-homeless-or-marginally-housed-persons
#19
William G Honer, Alejandro Cervantes-Larios, Andrea A Jones, Fidel Vila-Rodriguez, Julio S Montaner, Howard Tran, Jimmy Nham, William J Panenka, Donna J Lang, Allen E Thornton, Talia Vertinsky, Alasdair M Barr, Ric M Procyshyn, Geoffrey N Smith, Tari Buchanan, Mel Krajden, Michael Krausz, G William MacEwan, Kristina M Gicas, Olga Leonova, Verena Langheimer, Alexander Rauscher, Krista Schultz
OBJECTIVE: The Hotel Study was initiated in Vancouver's Downtown East Side (DTES) neighborhood to investigate multimorbidity in homeless or marginally housed people. We evaluated the clinical effectiveness of existing, illness-specific treatment strategies and assessed the effectiveness of health care delivery for multimorbid illnesses. METHOD: For context, we mapped the housing locations of patients presenting for 552,062 visits to the catchment hospital emergency department (2005-2013)...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28192541/immune-driven-alterations-in-mucin-sulphation-is-an-important-mediator-of-trichuris-muris-helminth-expulsion
#20
Sumaira Z Hasnain, Paul A Dawson, Rohan Lourie, Peter Hutson, Hui Tong, Richard K Grencis, Michael A McGuckin, David J Thornton
Mucins are heavily glycosylated proteins that give mucus its gel-like properties. Moreover, the glycans decorating the mucin protein core can alter the protective properties of the mucus barrier. To investigate whether these alterations could be parasite-induced we utilized the Trichuris muris (T. muris) infection model, using different infection doses and strains of mice that are resistant (high dose infection in BALB/c and C57BL6 mice) or susceptible (high dose infection in AKR and low dose infection in BALB/c mice) to chronic infection by T...
February 2017: PLoS Pathogens
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