keyword
https://read.qxmd.com/read/38547414/exploring-the-association-between-adolescent-perceived-parental-monitoring-on-dietary-intake
#1
JOURNAL ARTICLE
Bridie Osman, Katrina E Champion, Louise Thornton, Tracy Burrows, Scarlett Smout, Emily Hunter, Matthew Sunderland, Maree Teesson, Nicola C Newton, Lauren A Gardner
Parenting practices such as parental monitoring are known to positively impact dietary behaviours in offspring. However, links between adolescent-perceived parental monitoring and dietary outcomes have rarely been examined and never in an Australian context. This study investigated whether adolescent-perceived parental monitoring is associated with more fruit and vegetable, and less sugar-sweetened beverages (SSB) and junk food consumption in Australian adolescents. Cross-sectional data was collected as part of baseline measurement for a randomised controlled trial in 71 Australian schools in 2019...
March 28, 2024: Maternal & Child Nutrition
https://read.qxmd.com/read/38546535/nk1-tachykinin-receptor-antagonist-treatment-reduces-cerebral-edema-and-intracranial-pressure-in-an-ovine-model-of-ischemic-stroke
#2
JOURNAL ARTICLE
Annabel J Sorby-Adams, Oana C Marian, Isabella M Bilecki, Levi E Elms, Nawaf Yassi, Rebecca J Hood, Janet K Coller, Shannon M Stuckey, W Taylor Kimberly, Tracy D Farr, Anna V Leonard, Emma Thornton, Robert Vink, Renée J Turner
Following ischemic stroke, substance P (SP)-mediated neurogenic inflammation is associated with profound blood-brain barrier (BBB) dysfunction, cerebral edema, and elevated intracranial pressure (ICP). SP elicits its effects by binding the neurokinin 1 tachykinin receptor (NK1-R), with administration of an NK1-R antagonist shown to ameliorate BBB dysfunction and cerebral edema in rodent and permanent ovine stroke models. Given the importance of reperfusion in clinical stroke, this study examined the efficacy of NK1-R antagonist treatment in reducing cerebral edema and ICP in an ovine model of transient middle cerebral artery occlusion (tMCAo)...
March 28, 2024: Journal of Cerebral Blood Flow and Metabolism
https://read.qxmd.com/read/38510270/picture-perfect-standardizing-and-safekeeping-clinical-photography-in-plastic-surgery
#3
JOURNAL ARTICLE
Sarah M Thornton, Pradeep K Attaluri, Peter J Wirth, Ellen C Shaffrey, Robert E George, M Kristine Carbullido, Venkat K Rao
Plastic surgery relies heavily on clinical photography to document preoperative and postoperative changes, visualize surgical approaches, and evaluate outcomes. However, the contemporary landscape of plastic surgery photography faces challenges, including a lapse in standards due to the prevalence of smartphones, social media platforms, and security concerns related to data storage and cyberattacks. In this comprehensive review, the authors aim to provide plastic surgeons with practical guidelines for achieving standardized, high-quality clinical photography while navigating the evolving landscape of technology, security, and ethical considerations...
2024: Aesthetic surgery journal. Open forum
https://read.qxmd.com/read/38481013/parental-concerns-about-genital-differences-in-children-with-congenital-adrenal-hyperplasia-persist-regardless-of-the-selected-intervention
#4
JOURNAL ARTICLE
Julie Alderson, Maia Thornton, Mars Skae, Julie Jones, Nicky Nicoll, Diana Harcourt, Mark Woodward, Elizabeth C Crowne
BACKGROUND: Congenital Adrenal Hyperplasia (CAH) due to 21-hydroxylase deficiency (21HD) can affect the in utero development of the genital anatomy of people with the 46XX karyotype. Health professionals engage parents in decision-making regarding managing genitals with this difference, including genital surgery options and patient communication. AIM: We sought to investigate parental communication with their daughters regarding clitoral size variation related to neonatal CAH...
March 13, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38473094/myokines-produced-by-cultured-bovine-satellite-cells-harvested-from-3-and-11-month-old-angus-steers
#5
JOURNAL ARTICLE
Katie A Shira, Brenda M Murdoch, Kara J Thornton, Caleb C Reichhardt, Gabrielle M Becker, Gwinyai E Chibisa, Gordon K Murdoch
The myokines interleukin 6 (IL-6), interleukin 15 (IL-15), myonectin (CTRP15), fibronectin type III domain containing protein 5/irisin (FNDC5), and brain-derived neurotrophic factor (BDNF) are associated with skeletal muscle cell proliferation, differentiation, and muscle hypertrophy in biomedical model species. This study evaluated whether these myokines are produced by cultured bovine satellite cells (BSCs) harvested from 3- and 11-month-old commercial black Angus steers and if the expression and secretion of these targets change across 0, 12, 24, and 48 h in vitro...
February 24, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38453803/identification-and-prioritisation-of-items-for-a-draft-participant-reported-questionnaire-to-measure-use-of-social-care-informal-care-aids-and-adaptations
#6
JOURNAL ARTICLE
Kirsty M Garfield, Gail A Thornton, Samantha Husbands, Ailsa Cameron, William Hollingworth, Sian M Noble, Paul Roy, Joanna C Thorn
BACKGROUND: Resource-use measurement is integral for assessing cost-effectiveness within trial-based economic evaluations. Methods for gathering resource-use data from participants are not well developed, with questionnaires typically produced for each trial and rarely validated. The healthcare module of a generic, modular resource-use measure, designed for collecting self-report resource-utilisation data, has recently been developed in the UK. The objective of this research is to identify and prioritise items for new, bolt-on modules, covering informal care, social care and personal expenses incurred due to health and care needs...
March 7, 2024: PharmacoEconomics Open
https://read.qxmd.com/read/38438120/-it-s-on-your-shoulders-now-transitioning-from-child-to-adult-uk-cleft-lip-palate-services-an-exploration-of-young-adults-narratives
#7
JOURNAL ARTICLE
Danielle McWilliams, Maia Thornton, Matthew Hotton, Marc C Swan, Nicola Marie Stock
OBJECTIVES: Treatment for cleft lip and/or palate (CL/P) in the United Kingdom is administered on a standardised pathway from diagnosis to early adulthood, with options to be re-referred in later life. At age 16, patients become responsible for their treatment decisions. Evidence from the wider health literature indicates this transition can be challenging and that this population may require additional support. The present study explored young people's experiences of transition to adult care in the context of CL/P services, with the aim of identifying support needs and informing future service delivery...
March 4, 2024: Cleft Palate-craniofacial Journal
https://read.qxmd.com/read/38427148/health-service-utilization-in-adolescents-following-a-first-arrest-the-role-of-antisocial-behavior-callous-unemotional-traits-and-juvenile-justice-system-processing
#8
JOURNAL ARTICLE
Julianne S Speck, Paul J Frick, Erin P Vaughan, Toni M Walker, Emily L Robertson, James V Ray, Tina D Wall Myers, Laura C Thornton, Laurence Steinberg, Elizabeth Cauffman
Previous research indicates that youth exhibiting antisocial behavior are at risk for utilizing a disproportionate amount of health services compared to youth without these problems. The present study investigates whether being processed by the juvenile justice system and showing callous-unemotional (CU) traits independently predict health service utilization (medical and mental health service use and out-of-home placement) over and above the severity of antisocial behavior across adolescence. A total of 766 participants who had been arrested for the first time in adolescence provided data at ten appointments over a period of seven years...
March 1, 2024: Administration and Policy in Mental Health
https://read.qxmd.com/read/38410889/exploring-recent-decreases-in-first-molar-sealants-among-us-children
#9
JOURNAL ARTICLE
M Lin, S O Griffin, C H Li, L Wei, L Espinoza, C Y Wang, G Thornton-Evans
Analyses of National Health and Nutrition Examination Survey (NHANES) data suggested a significant decrease in sealant prevalence among children between 2011 to 2014 and 2015 to 2018. We explore whether this decrease could be associated with possible changes in 1) clinical sealant delivery, 2) dental materials (i.e., increased use of glass ionomer [GI] sealants resulting in an inability to detect sealant fragments that still provide preventive benefits or increased use of composite restorations leading to misclassifying sealants as restorations), and 3) examination sensitivity and specificity...
February 27, 2024: Journal of Dental Research
https://read.qxmd.com/read/38408303/effect-of-aggregation-and-molecular-size-on-the-ice-nucleation-efficiency-of-proteins
#10
JOURNAL ARTICLE
Alyssa N Alsante, Daniel C O Thornton, Sarah D Brooks
Aerosol acts as ice-nucleating particles (INPs) by catalyzing the formation of ice crystals in clouds at temperatures above the homogeneous nucleation threshold (-38 °C). In this study, we show that the immersion mode ice nucleation efficiency of the environmentally relevant protein, ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO), occurs at temperatures between -6.8 and -31.6 °C. Further, we suggest that this range is controlled by the RuBisCO concentration and protein aggregation. The warmest median nucleation temperature (-7...
February 26, 2024: Environmental Science & Technology
https://read.qxmd.com/read/38370737/unfolded-von-willebrand-factor-binds-protein-s-and-reduces-anticoagulant-activity
#11
Martha M S Sim, Molly Y Mollica, Hammodah R Alfar, Melissa Hollifield, Dominic W Chung, Xiaoyun Fu, Siva Gandhapudi, Daniëlle M Coenen, Kanakanagavalli Shravani Prakhya, Dlovan F D Mahmood, Meenakshi Banerjee, Chi Peng, Xian Li, Alice C Thornton, James Z Porterfield, Jamie L Sturgill, Gail A Sievert, Marietta Barton-Baxter, Ze Zheng, Kenneth S Campbell, Jerold G Woodward, José A López, Sidney W Whiteheart, Beth A Garvy, Jeremy P Wood
Protein S (PS), the critical plasma cofactor for the anticoagulants tissue factor (TF) pathway inhibitor (TFPI) and activated protein C (APC), circulates in two functionally distinct pools: free (anticoagulant) or bound to complement component 4b-binding protein (C4BP) (anti-inflammatory). Acquired free PS deficiency is detected in several viral infections, but its cause is unclear. Here, we identified a shear-dependent interaction between PS and von Willebrand Factor (VWF) by mass spectrometry. Consistently, plasma PS and VWF comigrated in both native and agarose gel electrophoresis...
February 9, 2024: bioRxiv
https://read.qxmd.com/read/38367758/maternal-vaccination-against-covid-19-and-neonatal-outcomes-during-omicron-intercovid-2022-study
#12
JOURNAL ARTICLE
Fernando C Barros, Robert B Gunier, Albertina Rego, Loïc Sentilhes, Stephen Rauch, Serena Gandino, Jagjit S Teji, Jim G Thornton, Alisa B Kachikis, Ricardo Nieto, Rachel Craik, Paolo I Cavoretto, Adele Winsey, Paola Roggero, Gabriel B Rodriguez, Valeria Savasi, Erkan Kalafat, Francesca Giuliani, Marta Fabre, Anne Caroline Benski, Irma Alejandra Coronado-Zarco, Stefania Livio, Adela Ostrovska, Nerea Maiz, Fabiola R Castedo Camacho, Ashley Peterson, Philippe Deruelle, Carolina Giudice, Roberto A Casale, Laurent J Salomon, Constanza P Soto Conti, Federico Prefumo, Ehab Zakaria Mohamed Elbayoumy, Marynéa Vale, Valeria Hernández, Katherine Chandler, Milagros Risso, Emily Marler, Daniela M Cáceres, Guadalupe Albornoz Crespo, Ernawati Ernawati, Michal Lipschuetz, Shabina Ariff, Ken Takahashi, Carmen Vecchiarelli, Teresa Hubka, Satoru Ikenoue, Gabriela Tavchioska, Babagana Bako, Adejumoke I Ayede, Brenda Eskenazi, Zulfiqar A Bhutta, Stephen H Kennedy, Aris T Papageorghiou, Jose Villar
BACKGROUND: In early 2023, when Omicron was the variant of concern, we showed that vaccinating pregnant women decreased the risk of severe COVID-19 related complications, and maternal morbidity and mortality. OBJECTIVES: To analyze the impact of COVID-19 during pregnancy on newborns and the effects of maternal COVID-19 vaccination on neonatal outcomes, when Omicron was the variant of concern. STUDY DESIGN: INTERCOVID-2022 is a large, prospective, observational study, conducted in 40 hospitals across 18 countries, from November 27, 2021 (the day after the World Health Organization declared Omicron the variant of concern) to June 30, 2022, to assess the effect of COVID-19 in pregnancy on maternal and neonatal outcomes, as well as vaccine effectiveness (VE)...
February 15, 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38354856/loss-of-mitochondrial-pyruvate-carrier-1-supports-proline-dependent-proliferation-and-collagen-biosynthesis-in-ovarian-cancer
#13
JOURNAL ARTICLE
M R Farook, Z Croxford, S Morgan, A D Horlock, A Holt, A Rees, B J Jenkins, C Tse, E Stanton, D M Davies, C A Thornton, N Jones, I M Sheldon, E E Vincent, J G Cronin
The pyruvate transporter MPC1 (mitochondrial pyruvate carrier 1) acts as a tumour-suppressor, loss of which correlates with a pro-tumorigenic phenotype and poor survival in several tumour types. In high-grade serous ovarian cancers (HGSOC), patients display copy number loss of MPC1 in around 78% of cases and reduced MPC1 mRNA expression. To explore the metabolic effect of reduced expression, we demonstrate that depleting MPC1 in HGSOC cell lines drives expression of key proline biosynthetic genes; PYCR1, PYCR2 and PYCR3, and biosynthesis of proline...
February 12, 2024: Molecular Metabolism
https://read.qxmd.com/read/38347808/interplay-of-polygenic-liability-with-birth-related-somatic-and-psychosocial-factors-in-anorexia-nervosa-risk-a-nationwide-study
#14
JOURNAL ARTICLE
Natalie M Papini, Emily Presseller, Cynthia M Bulik, Katrine Holde, Janne T Larsen, Laura M Thornton, Clara Albiñana, Bjarni J Vilhjálmsson, Preben B Mortensen, Zeynep Yilmaz, Liselotte V Petersen
BACKGROUND: Although several types of risk factors for anorexia nervosa (AN) have been identified, including birth-related factors, somatic, and psychosocial risk factors, their interplay with genetic susceptibility remains unclear. Genetic and epidemiological interplay in AN risk were examined using data from Danish nationwide registers. AN polygenic risk score (PRS) and risk factor associations, confounding from AN PRS and/or parental psychiatric history on the association between the risk factors and AN risk, and interactions between AN PRS and each level of target risk factor on AN risk were estimated...
February 13, 2024: Psychological Medicine
https://read.qxmd.com/read/38325353/sex-specific-behavioural-deficits-in-adulthood-following-acute-activation-of-the-gabaa-receptor-in-the-neonatal-mouse
#15
JOURNAL ARTICLE
Ane Goikolea-Vives, Cathy Fernandes, Michael S C Thomas, Claire Thornton, Helen B Stolp
INTRODUCTION: Sex differences exist in the prevalence of neurodevelopmental disorders (NDDs). Part of the aetiology of NDDs has been proposed to be alterations in the balance between excitatory and inhibitory neurotransmission, leading to the question of whether males and females respond differently to altered neurotransmitter balance. We investigated whether pharmacological alteration of GABAA signalling in early development results in sex-dependent changes in adult behaviours associated with NDDs...
February 7, 2024: Developmental Neuroscience
https://read.qxmd.com/read/38319419/potential-of-stable-isotope-analysis-to-deduce-anaerobic-biodegradation-of-ethyl-tert-butyl-ether-etbe-and-tert-butyl-alcohol-tba-in-groundwater-a-review
#16
REVIEW
Marcelle J van der Waals, Steven F Thornton, Stephen A Rolfe, Luc Rock, Jonathan W N Smith, Tom N P Bosma, Jan Gerritse
Understanding anaerobic biodegradation of ether oxygenates beyond MTBE in groundwater is important, given that it is replaced by ETBE as a gasoline additive in several regions. The lack of studies demonstrating anaerobic biodegradation of ETBE, and its product TBA, reflects the relative resistance of ethers and alcohols with a tertiary carbon atom to enzymatic attack under anoxic conditions. Anaerobic ETBE- or TBA-degrading microorganisms have not been characterized. Only one field study suggested anaerobic ETBE biodegradation...
February 6, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38310129/improving-polygenic-risk-prediction-in-admixed-populations-by-explicitly-modeling-ancestral-differential-effects-via-gaudi
#17
JOURNAL ARTICLE
Quan Sun, Bryce T Rowland, Jiawen Chen, Anna V Mikhaylova, Christy Avery, Ulrike Peters, Jessica Lundin, Tara Matise, Steve Buyske, Ran Tao, Rasika A Mathias, Alexander P Reiner, Paul L Auer, Nancy J Cox, Charles Kooperberg, Timothy A Thornton, Laura M Raffield, Yun Li
Polygenic risk scores (PRS) have shown successes in clinics, but most PRS methods focus only on participants with distinct primary continental ancestry without accommodating recently-admixed individuals with mosaic continental ancestry backgrounds for different segments of their genomes. Here, we develop GAUDI, a novel penalized-regression-based method specifically designed for admixed individuals. GAUDI explicitly models ancestry-differential effects while borrowing information across segments with shared ancestry in admixed genomes...
February 3, 2024: Nature Communications
https://read.qxmd.com/read/38295404/radioactive-seed-localization-is-a-safe-and-effective-tool-for-breast-cancer-surgery-an-evaluation-of-over-25-000-cases
#18
JOURNAL ARTICLE
D Miodownik, D Bierman, C Thornton, T Moo, K Feigin, A Damato, T Le, M Williamson, K Prasad, B Chu, L Dauer, N Saphier, P Zanzonico, M Morrow, M Bellamy
Radioactive seed localization (RSL) provides a precise and efficient method for removing non-palpable breast lesions. It has proven to be a valuable addition to breast surgery, improving perioperative logistics and patient satisfaction. This retrospective review examines the lessons learned from a high-volume cancer center's RSL program after 10 years of practice and over 25,000 cases. We provide an updated model for assessing the patient's radiation dose from RSL seed implantation and demonstrate the safety of RSL to staff members...
January 31, 2024: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://read.qxmd.com/read/38273412/-they-should-ve-talked-to-us-more-lay-health-advisors-experiences-with-community-engaged-hypertension-research
#19
JOURNAL ARTICLE
Cyleste C Collins, Mona Shediac-Rizkallah, Jacqueline Dolata, Erika Hood, Elodie Nonguierma, Daryl Thornton
BACKGROUND: Lay health advisors (LHAs) are increasingly being used to increase patient and public involvement in research, disseminate health information, and work toward preventing health disparities within communities at risk. This research explored LHAs' experiences with training and recruiting for a hypertension research project which ended due to minimal enrollment. METHODS: The methodological design was qualitative description. One face-to-face semi-structured focus group was held with eight African American LHAs in Cleveland, Ohio, in the fall of 2019...
January 25, 2024: Research Involvement and Engagement
https://read.qxmd.com/read/38271583/myocardial-scar-and-remodelling-predict-long-term-mortality-in-severe-aortic-stenosis-beyond-10-years
#20
JOURNAL ARTICLE
George D Thornton, Vassilios S Vassiliou, Tarique A Musa, Nikoo Aziminia, Neil Craig, Abhishek Dattani, Rhodri H Davies, Gabriella Captur, James C Moon, Marc R Dweck, Saul G Myerson, Sanjay K Prasad, Gerry P McCann, John P Greenwood, Anvesha Singh, Thomas A Treibel
No abstract text is available yet for this article.
January 25, 2024: European Heart Journal
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