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Thornton, C

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https://www.readbyqxmd.com/read/28068978/effectiveness-of-the-yourcall%C3%A2-text-message-intervention-to-reduce-harmful-drinking-in-patients-discharged-from-trauma-wards-protocol-for-a-randomised-controlled-trial
#1
Shanthi Ameratunga, Bridget Kool, Sarah Sharpe, Papaarangi Reid, Arier Lee, Ian Civil, Gordon Smith, Vanessa Thornton, Matthew Walker, Robyn Whittaker
BACKGROUND: Behavioural brief interventions (BI) can support people to reduce harmful drinking but multiple barriers impede the delivery and equitable access to these. To address this challenge, we developed YourCall™, a novel short message service (SMS) text message intervention incorporating BI principles. This protocol describes a trial evaluating the effectiveness of YourCall™ (compared to usual care) in reducing hazardous drinking and alcohol related harm among injured adults who received in-patient care...
January 9, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28054598/antarctic-ice-sheet-discharge-driven-by-atmosphere-ocean-feedbacks-at-the-last-glacial-termination
#2
C J Fogwill, C S M Turney, N R Golledge, D M Etheridge, M Rubino, D P Thornton, A Baker, J Woodward, K Winter, T D van Ommen, A D Moy, M A J Curran, S M Davies, M E Weber, M I Bird, N C Munksgaard, L Menviel, C M Rootes, B Ellis, H Millman, J Vohra, A Rivera, A Cooper
Reconstructing the dynamic response of the Antarctic ice sheets to warming during the Last Glacial Termination (LGT; 18,000-11,650 yrs ago) allows us to disentangle ice-climate feedbacks that are key to improving future projections. Whilst the sequence of events during this period is reasonably well-known, relatively poor chronological control has precluded precise alignment of ice, atmospheric and marine records, making it difficult to assess relationships between Antarctic ice-sheet (AIS) dynamics, climate change and sea level...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28054251/cirrhosis-and-liver-transplantation-in-patients-co-infected-with-hiv-and-hepatitis-b-or-c-an-observational-cohort-study
#3
Charlotte Warren-Gash, Kate Childs, Alicia Thornton, Sanjay Bhagani, Shirin Demma, Ankur Srivastava, Clifford Leen, Kosh Agarwal, Alison J Rodger, Caroline A Sabin
This study assessed the likelihood of referral for liver transplantation assessment in a prospective cohort of patients co-infected with HIV and hepatitis B or C with complications of cirrhosis. There were 141 co-infected patients from 11 UK centres with at least one complication of cirrhosis recorded (either decompensation or hepatocellular carcinoma) out of 772 identified with cirrhosis and/or HCC. Only 23 of these 141 (16.3%) were referred for liver transplantation assessment, even though referral is recommended for co-infected patients after the first decompensation episode...
January 4, 2017: Infection
https://www.readbyqxmd.com/read/28039329/a-genome-wide-interaction-analysis-of-tricyclic-tetracyclic-antidepressants-and-rr-and-qt-intervals-a-pharmacogenomics-study-from-the-cohorts-for-heart-and-aging-research-in-genomic-epidemiology-charge-consortium
#4
Raymond Noordam, Colleen M Sitlani, Christy L Avery, James D Stewart, Stephanie M Gogarten, Kerri L Wiggins, Stella Trompet, Helen R Warren, Fangui Sun, Daniel S Evans, Xiaohui Li, Jin Li, Albert V Smith, Joshua C Bis, Jennifer A Brody, Evan L Busch, Mark J Caulfield, Yii-Der I Chen, Steven R Cummings, L Adrienne Cupples, Qing Duan, Oscar H Franco, Rául Méndez-Giráldez, Tamara B Harris, Susan R Heckbert, Diana van Heemst, Albert Hofman, James S Floyd, Jan A Kors, Lenore J Launer, Yun Li, Ruifang Li-Gao, Leslie A Lange, Henry J Lin, Renée de Mutsert, Melanie D Napier, Christopher Newton-Cheh, Neil Poulter, Alexander P Reiner, Kenneth M Rice, Jeffrey Roach, Carlos J Rodriguez, Frits R Rosendaal, Naveed Sattar, Peter Sever, Amanda A Seyerle, P Eline Slagboom, Elsayed Z Soliman, Nona Sotoodehnia, David J Stott, Til Stürmer, Kent D Taylor, Timothy A Thornton, André G Uitterlinden, Kirk C Wilhelmsen, James G Wilson, Vilmundur Gudnason, J Wouter Jukema, Cathy C Laurie, Yongmei Liu, Dennis O Mook-Kanamori, Patricia B Munroe, Jerome I Rotter, Ramachandran S Vasan, Bruce M Psaty, Bruno H Stricker, Eric A Whitsel
BACKGROUND: Increased heart rate and a prolonged QT interval are important risk factors for cardiovascular morbidity and mortality, and can be influenced by the use of various medications, including tricyclic/tetracyclic antidepressants (TCAs). We aim to identify genetic loci that modify the association between TCA use and RR and QT intervals. METHODS AND RESULTS: We conducted race/ethnic-specific genome-wide interaction analyses (with HapMap phase II imputed reference panel imputation) of TCAs and resting RR and QT intervals in cohorts of European (n=45 706; n=1417 TCA users), African (n=10 235; n=296 TCA users) and Hispanic/Latino (n=13 808; n=147 TCA users) ancestry, adjusted for clinical covariates...
December 30, 2016: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28031178/otitis-prone-children-produce-functional-antibodies-to-pneumolysin-and-pneumococcal-polysaccharides
#5
Lea-Ann S Kirkham, Selma P Wiertsema, Karli J Corscadden, Tulia Mateus, Gemma L Mullaney, Guicheng Zhang, Peter C Richmond, Ruth B Thornton
BACKGROUND: The pneumococcus is a major otitis media (OM) pathogen but data are conflicting on whether otitis-prone children have impaired humoral immunity to pneumococcal antigens. We and others have shown that otitis-prone and healthy children have similar antibody titres to pneumococcal proteins and polysaccharides (vaccine and non-vaccine type), however the quality of antibodies from otitis-prone children has not been investigated. Antibody function, rather than titre, is considered to better correlate with protection from pneumococcal disease...
December 28, 2016: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28027985/characterization-of-basic-immune-function-parameters-in-the-fathead-minnow-pimephales-promelas-a-common-model-in-environmental-toxicity-testing
#6
Leah M Thornton, Meriel C LeSueur, Alexandra T Yost, Dane A Stephens, James T Oris, Marlo K Sellin Jeffries
The fathead minnow (Pimephales promelas) is an environmental sentinel species, commonly used in toxicity testing. However, there is a lack of data regarding basic immune function in this species. To improve the usefulness of the fathead minnow as a model for basic immune function and immunotoxicity, this study sought to 1) compare the differential expression of immune function genes in naïve fathead minnows and 2) determine the effects of pathogen exposure on immune gene expression and spleen index. To accomplish this, kidney, spleen and liver tissue were collected three days post injection (dpi) from adult male fathead minnows from each of the following groups: 1) uninjected control 2) sham-injected (Hank's balanced salt solution) and 3) pathogen-injected (Yersinia ruckeri)...
December 24, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28012512/no-evidence-for-impaired-humoral-immunity-to-pneumococcal-proteins-in-australian-aboriginal-children-with-otitis-media
#7
Ruth B Thornton, Lea-Ann S Kirkham, Karli J Corscadden, Harvey L Coates, Shyan Vijayasekaran, Jessica Hillwood, Sophie Toster, Phillipa Edminston, Guicheng Zhang, Anthony Keil, Peter C Richmond
BACKGROUND: The Australian Aboriginal population experiences disproportionately high rates of otitis media (OM). Streptococcus pneumoniae is one of the main pathogens responsible for OM and currently no vaccine offering cross strain protection exists. Vaccines consisting of conserved antigens to S. pneumoniae may reduce the burden of OM in high-risk populations; however no data exists examining naturally acquired antibody in Aboriginal children with OM. METHODS: Serum and salivary IgA and IgG were measured against the S...
January 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28000743/multi-scale-porosity-tio2-scaffolds-grown-by-innovative-sputtering-methods-for-high-throughput-hybrid-photovoltaics
#8
Salvatore Sanzaro, Emanuele Smecca, Giovanni Mannino, Corrado Bongiorno, Giovanna Pellegrino, Fortunato Neri, Graziella Malandrino, Maria Rita Catalano, Guglielmo Guido Condorelli, Rosabianca Iacobellis, Luisa De Marco, Corrado Spinella, Antonino La Magna, Alessandra Alberti
We propose an up-scalable, reliable, contamination-free, rod-like TiO2 material grown by a new method based on sputtering deposition concepts which offers a multi-scale porosity, namely: an intra-rods nano-porosity (1-5 nm) arising from the Thornton's conditions and an extra-rods meso-porosity (10-50 nm) originating from the spatial separation of the Titanium and Oxygen sources combined with a grazing Ti flux. The procedure is simple, since it does not require any template layer to trigger the nano-structuring, and versatile, since porosity and layer thickness can be easily tuned; it is empowered by the lack of contaminations/solvents and by the structural stability of the material (at least) up to 500 °C...
December 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27995962/engineering-the-surface-properties-of-a-human-monoclonal-antibody-prevents-self-association-and-rapid-clearance-in-vivo
#9
Claire L Dobson, Paul W A Devine, Jonathan J Phillips, Daniel R Higazi, Christopher Lloyd, Bojana Popovic, Joanne Arnold, Andrew Buchanan, Arthur Lewis, Joanne Goodman, Christopher F van der Walle, Peter Thornton, Lisa Vinall, David Lowne, Anna Aagaard, Lise-Lotte Olsson, Anna Ridderstad Wollberg, Fraser Welsh, Theodoros K Karamanos, Clare L Pashley, Matthew G Iadanza, Neil A Ranson, Alison E Ashcroft, Alistair D Kippen, Tristan J Vaughan, Sheena E Radford, David C Lowe
Uncontrolled self-association is a major challenge in the exploitation of proteins as therapeutics. Here we describe the development of a structural proteomics approach to identify the amino acids responsible for aberrant self-association of monoclonal antibodies and the design of a variant with reduced aggregation and increased serum persistence in vivo. We show that the human monoclonal antibody, MEDI1912, selected against nerve growth factor binds with picomolar affinity, but undergoes reversible self-association and has a poor pharmacokinetic profile in both rat and cynomolgus monkeys...
December 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27995742/tracking-the-amphibian-pathogens-batrachochytrium-dendrobatidis-and-batrachochytrium-salamandrivorans-using-a-highly-specific-monoclonal-antibody-and-lateral-flow-technology
#10
Michael J Dillon, Andrew E Bowkett, Michael J Bungard, Katie M Beckman, Michelle F O'Brien, Kieran Bates, Matthew C Fisher, Jamie R Stevens, Christopher R Thornton
The fungus Batrachochytrium dendrobatidis (Bd) causes chytridiomycosis, a lethal epizootic disease of amphibians. Rapid identification of the pathogen and biosecurity is essential to prevent its spread, but current laboratory-based tests are time-consuming and require specialist equipment. Here, we describe the generation of an IgM monoclonal antibody (mAb), 5C4, specific to Bd as well as the related salamander and newt pathogen Batrachochytrium salamandrivorans (Bsal). The mAb, which binds to a glycoprotein antigen present on the surface of zoospores, sporangia and zoosporangia, was used to develop a lateral-flow assay (LFA) for rapid (15 min) detection of the pathogens...
December 19, 2016: Microbial Biotechnology
https://www.readbyqxmd.com/read/27994867/an-observational-study-of-health-literacy-and-medication-adherence-in-adult-kidney-transplant-recipients
#11
Maryam N Demian, R Jean Shapiro, Wendy Loken Thornton
BACKGROUND: There is a high prevalence of non-adherence to immunosuppressants in kidney transplant recipients. Although limited health literacy is common in kidney recipients and is linked to adverse outcomes in other medical populations, its effect on medication adherence in kidney transplant recipients remains poorly understood. The objective was to investigate the effect of lower health literacy on immunosuppressant adherence. METHODS: Kidney recipients who were at least 6 months post-transplant and outpatients of Vancouver General Hospital in B...
December 2016: Clinical Kidney Journal
https://www.readbyqxmd.com/read/27991181/the-pivotal-role-of-the-right-parietal-lobe-in-temporal-attention
#12
Sara Agosta, Denise Magnago, Sarah Tyler, Emily Grossman, Emanuela Galante, Francesco Ferraro, Nunzia Mazzini, Gabriele Miceli, Lorella Battelli
The visual system is extremely efficient at detecting events across time even at very fast presentation rates; however, discriminating the identity of those events is much slower and requires attention over time, a mechanism with a much coarser resolution [Cavanagh, P., Battelli, L., & Holcombe, A. O. Dynamic attention. In A. C. Nobre & S. Kastner (Eds.), The Oxford handbook of attention (pp. 652-675). Oxford: Oxford University Press, 2013]. Patients affected by right parietal lesion, including the TPJ, are severely impaired in discriminating events across time in both visual fields [Battelli, L...
December 19, 2016: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/27981030/9-4%C3%A2-t-mr-microscopy-of-the-substantia-nigra-with-pathological-validation-in-controls-and-disease
#13
L A Massey, M A Miranda, O Al-Helli, H G Parkes, J S Thornton, P-W So, M J White, L Mancini, C Strand, J Holton, A J Lees, T Revesz, T A Yousry
BACKGROUND: The anatomy of the substantia nigra on conventional MRI is controversial. Even using histological techniques it is difficult to delineate with certainty from surrounding structures. We sought to define the anatomy of the SN using high field spin-echo MRI of pathological material in which we could study the anatomy in detail to corroborate our MRI findings in controls and Parkinson's disease and progressive supranuclear palsy. METHODS: 23 brains were selected from the Queen Square Brain Bank (10 controls, 8 progressive supranuclear palsy, 5 Parkinson's disease) and imaged using high field 9...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27972569/healthcare-resource-utilisation-is-associated-with-phase-of-chronic-myeloid-leukaemia-cml-results-of-a-clinical-expert-survey-in-england-and-wales
#14
R E Robson, S Chiroli, S Iannazzo, A C Thornton, K Tolley
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27943276/validation-of-a-microdose-probe-drug-cocktail-for-clinical-drug-interaction-assessments-for-drug-transporters-and-cyp3a
#15
T Prueksaritanont, D A Tatosian, X Chu, R Railkar, R Evers, C Chavez-Eng, R Lutz, W Zeng, J Yabut, G H Chan, X Cai, A H Latham, J Hehman, D Stypinski, J Brejda, C Zhou, B Thornton, K P Bateman, I Fraser, S A Stoch
A microdose cocktail containing midazolam, dabigatran etexilate, pitavastatin, rosuvastatin, and atorvastatin has been established to allow simultaneous assessment of a perpetrator impact on the most common drug metabolizing enzyme, cytochrome P450 (CYP)3A, and the major transporters organic anion-transporting polypeptides (OATP)1B, breast cancer resistance protein (BCRP), and MDR1 P-glycoprotein (P-gp). The clinical utility of these microdose cocktail probe substrates was qualified by conducting clinical drug interaction studies with three inhibitors with different in vitro inhibitory profiles (rifampin, itraconazole, and clarithromycin)...
December 10, 2016: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27942789/evaluation-of-the-automated-microflow-%C3%A2-and-metafer%C3%A2-platforms-for-high-throughput-micronucleus-scoring-and-dose-response-analysis-in-human-lymphoblastoid-tk6-cells
#16
Jatin R Verma, Benjamin J Rees, Eleanor C Wilde, Catherine A Thornton, Gareth J S Jenkins, Shareen H Doak, George E Johnson
The use of manual microscopy for the scoring of chromosome damage in the in vitro micronucleus assay is often associated with user subjectivity. This level of subjectivity can be reduced by using automated platforms, which have added value of faster with high-throughput and multi-endpoint capabilities. However, there is a need to assess the reproducibility and sensitivity of these automated platforms compared with the gold standard of the manual scoring. The automated flow cytometry-based MicroFlow(®) and image analysis-based Metafer™ were used for dose response analyses in human lymphoblastoid TK6 cells exposed to the model clastogen, methyl methanesulfonate (MMS), aneugen, carbendazim, and the weak genotoxic carcinogen, ochratoxin A (OTA)...
December 10, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27936421/catheter-directed-endovascular-application-of-thrombin-report-of-3-cases-and-review-of-the-literature
#17
Majid Maybody, David C Madoff, Raymond H Thornton, Steven A Morales, Chaya S Moskowitz, Meier Hsu, Lynn A Brody, Karen T Brown, Anne M Covey
PURPOSE: To report 3 new cases of catheter-directed endovascular application of thrombin and explore trends by analysis of published case series. MATERIALS AND METHODS: Institutional Review Board approved this retrospective study. All cases of non-tumoral arterial embolization performed from January 2003 to January 2015 at our institution were retrospectively reviewed. Thrombin was used in 7 of 589 cases. In 3 cases intra arterial thrombin was injected via catheter to treat active hemorrhage...
November 29, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27932298/modeling-birds-on-wires
#18
A Aydoğdu, P Frasca, C D'Apice, R Manzo, J M Thornton, B Gachomo, T Wilson, B Cheung, U Tariq, W Saidel, B Piccoli
In this paper we introduce a mathematical model to study the group dynamics of birds resting on wires. The model is agent-based and postulates attraction-repulsion forces between the interacting birds: the interactions are "topological", in the sense that they involve a given number of neighbors irrespective of their distance. The model is first mathematically analyzed and then simulated to study its main properties: we observe that the model predicts birds to be more widely spaced near the borders of each group...
December 5, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/27917982/climate-change-and-pastoralism-impacts-consequences-and-adaptation
#19
M Herrero, J Addison, C Bedelian, E Carabine, P Havlík, B Henderson, J Van De Steeg, P K Thornton
The authors discuss the main climate change impacts on pastoralist societies, including those on rangelands, livestock and other natural resources, and their extended repercussions on food security, incomes and vulnerability. The impacts of climate change on the rangelands of the globe and on the vulnerability of the people who inhabit them will be severe and diverse, and will require multiple, simultaneous responses. In higher latitudes, the removal of temperature constraints might increase pasture production and livestock productivity, but in tropical arid lands, the impacts are highly location specific, but mostly negative...
November 2016: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/27902640/minimal-endoillumination-levels-and-display-luminous-emittance-during-three-dimensional-heads-up-vitreoretinal-surgery
#20
Murtaza K Adam, Sarah Thornton, Carl D Regillo, Carl Park, Allen C Ho, Jason Hsu
PURPOSE: To determine minimal endoillumination levels required to perform 3-dimensional heads-up vitreoretinal surgery and to correlate endoillumination levels used for measurements of heads-up display (HUD) luminous emittance. METHODS: Prospective, observational surgical case series of 10 patients undergoing vitreoretinal surgery. Endoillumination levels were set to 40% of maximum output and were decreased at set intervals until the illumination level was 0%. Corresponding luminous emittance (lux) of the HUD was measured 40 cm from the display using a luxmeter (Dr...
November 29, 2016: Retina
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