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Thornton, C

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https://www.readbyqxmd.com/read/29045833/intestinal-fork-head-regulates-nutrient-absorption-and-promotes-longevity
#1
Ekin Bolukbasi, Mobina Khericha, Jennifer C Regan, Dobril K Ivanov, Jennifer Adcott, Miranda C Dyson, Tobias Nespital, Janet M Thornton, Nazif Alic, Linda Partridge
Reduced activity of nutrient-sensing signaling networks can extend organismal lifespan, yet the underlying biology remains unclear. We show that the anti-aging effects of rapamycin and reduced intestinal insulin/insulin growth factor (IGF) signaling (IIS) require the Drosophila FoxA transcription factor homolog Fork Head (FKH). Intestinal FKH induction extends lifespan, highlighting a role for the gut. FKH binds to and is phosphorylated by AKT and Target of Rapamycin. Gut-specific FKH upregulation improves gut barrier function in aged flies...
October 17, 2017: Cell Reports
https://www.readbyqxmd.com/read/29029576/marine-aerosols-and-clouds
#2
Sarah D Brooks, Daniel C O Thornton
The role of marine bioaerosols in cloud formation and climate is currently so uncertain that even the sign of the climate forcing is unclear. Marine aerosols form through direct emissions and through the conversion of gasphase emissions to aerosols in the atmosphere. The composition and size of aerosols determine how effective they are in catalyzing the formation of water droplets and ice crystals in clouds by acting as cloud condensation nuclei and ice nucleating particles, respectively. Marine organic aerosols may be sourced both from recent regional phytoplankton blooms that add labile organic matter to the surface ocean and from long-term global processes, such as the upwelling of old refractory dissolved organic matter from the deep ocean...
October 13, 2017: Annual Review of Marine Science
https://www.readbyqxmd.com/read/28971003/the-processing-of-animacy-information-is-disrupted-as-a-function-of-callous-unemotional-traits-in-youth-with-disruptive-behavior-disorders
#3
Laura C Thornton, Elizabeth A Penner, Zachary T Nolan, Christopher J Adalio, Stephen Sinclair, Harma Meffert, Soonjo Hwang, R James R Blair, Stuart F White
Atypical amygdala responses to emotional stimuli have been consistently reported in youth with Disruptive Behavior Disorders (DBDs; Conduct Disorder/Oppositional Defiant Disorder). However, responding to animacy stimuli has not been systematically investigated. Yet, the amygdala is known to be responsive to animacy stimuli and impairment in responsiveness to animacy information may have implications for social cognitive development. Twenty-nine youth with DBDs and 20 typically developing youth, matched for IQ, age (Mage  = 14...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28952672/long-term-follow-up-of-patients-with-spontaneous-clearance-of-hepatitis-c-does-viral-clearance-mean-cure
#4
M Iqbal, P A McCormick, M Cannon, N Murphy, P Flanagan, J E Kennelly, L Thornton
Up to 40% of patients with hepatitis C virus (HCV) antibodies are negative for HCV RNA at initial evaluation. If there is a risk of viral re-activation, long term follow-up is required with attendant financial, psychological and medical implications. We investigated the risk of re-activation in the Irish anti-D cohort. Information was obtained from the national hepatitis C database which includes data on patients infected by anti-D immunoglobulin in two large outbreaks, 1977-9 and 1991-94. As part of a screening programme, starting in 1994, 64,907 females exposed to anti-D immunoglobulin were evaluated...
June 9, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/28943747/african-american-and-black-caribbean-feelings-of-closeness-to-africans
#5
Michael C Thornton, Robert Joseph Taylor, Linda M Chatters, Ivy Forsythe-Brown
African American and Black Caribbean relations dominate research on interactions across black ethnic divides. Using National Survey of American Life data, we explore a different aspect of black interethnic attitudes: how close these groups feel toward Africans. African Americans and Black Caribbeans were largely similar in their feelings of closeness to Africans. For Black Caribbeans, younger and male respondents, those reporting higher levels of financial strain, living in the northeast and persons who immigrated to the United States at least 11 years ago, report feeling especially close to Africans...
2017: Identities (Yverdon)
https://www.readbyqxmd.com/read/28938063/severe-fetal-growth-restriction-at-26-32-weeks-key-messages-from-the-truffle-study
#6
EDITORIAL
C M Bilardo, K Hecher, G H A Visser, A T Papageorghiou, N Marlow, B Thilaganathan, A Van Wassenaer-Leemhuis, T Todros, K Marsal, T Frusca, B Arabin, C Brezinka, J B Derks, A Diemert, J J Duvekot, E Ferrazzi, W Ganzevoort, P Martinelli, E Ostermayer, D Schlembach, H Valensise, J Thornton, H Wolf, C Lees
No abstract text is available yet for this article.
September 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28926400/hepatitis-b-hepatitis-c-and-mortality-among-hiv-positive-individuals
#7
Alicia C Thornton, Sophie Jose, Sanjay Bhagani, David Chadwick, David Dunn, Richard Gilson, Janice Main, Mark Nelson, Alison Rodger, Chris Taylor, Elaney Youssef, Clifford Leen, Mark Gompels, Stephen Kegg, Achim Schwenk, Caroline Sabin
OBJECTIVES: To compare rates of all-cause, liver-related and AIDS-related mortality among individuals who are HIV mono-infected with those co-infected with HIV and hepatitis B (HBV) and/or hepatitis C (HCV) viruses. DESIGN: An ongoing observational cohort study collating routinely collected clinical data on HIV-positive individuals attending for care at HIV treatment centres throughout the UK. METHODS: Individuals were included if they had been seen for care from 2004 onwards and had tested for HBV and HCV...
September 18, 2017: AIDS
https://www.readbyqxmd.com/read/28917217/post-operative-c-reactive-protein-profile-following-abdominal-wall-reconstruction-with-transversus-abdominis-posterior-components-separation
#8
A Pearce, L Thornton, P A Sutton, C J Walsh
INTRODUCTION: Abdominal wall reconstruction using posterior component separation with transversus abdominis release (AWTAR) produces a unique post-operative CRP profile, when compared to routine elective colorectal operations. Therefore, we aim to establish the normal post-operative C-reactive protein (poCRP) profile following AWRTAR and reduce the unnecessary invasive interventions in patients already at greater risk of septic complications. METHODS: A retrospective analysis of daily poCRP levels was performed both for patients who underwent uncomplicated AWRTAR (n=12), and a comparator group of uncomplicated open right hemicolectomies (RH) matched for age and sex (n=24)...
August 24, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28912373/the-association-of-sleep-duration-and-quality-with-ckd-progression
#9
Ana C Ricardo, Kristen Knutson, Jinsong Chen, Lawrence J Appel, Lydia Bazzano, Eunice Carmona-Powell, Janet Cohan, Manjula Kurella Tamura, Susan Steigerwalt, John Daryl Thornton, Matthew Weir, Nicolas F Turek, Mahboob Rahman, Eve Van Cauter, James P Lash
Evidence suggests that sleep disorders are common in individuals with CKD, but the influence of sleep duration and quality on CKD progression is unknown. We examined the association of habitual sleep duration and quality with CKD progression in 431 Chronic Renal Insufficiency Cohort (CRIC) Study participants, of whom 48% were women and 50% had diabetes (mean age of 60 years old, mean eGFR =38 ml/min per 1.73 m(2), and median urine protein-to-creatinine ratio [UPCR] =0.20 g/g). We assessed sleep duration and quality by 5-7 days of wrist actigraphy and self-report...
September 14, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28859985/the-normal-trachea-is-cleaned-by-muc5b-mucin-bundles-from-the-submucosal-glands-coated-with-the-muc5ac-mucin
#10
Anna Ermund, Lauren N Meiss, Ana M Rodriguez-Pineiro, Andrea Bähr, Harriet E Nilsson, Sergio Trillo-Muyo, Caroline Ridley, David J Thornton, Jeffrey J Wine, Hans Hebert, Nikolai Klymiuk, Gunnar C Hansson
To understand the mucociliary clearance system, mucins were visualized by light, confocal and electron microscopy, and mucus was stained by Alcian blue and tracked by video microscopy on tracheal explants of newborn piglets. We observed long linear mucus bundles that appeared at the submucosal gland openings and were transported cephalically. The mucus bundles were shown by mass spectrometry and immunostaining to have a core made of MUC5B mucin and were coated with MUC5AC mucin produced by surface goblet cells...
October 21, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28855301/trem2-shedding-by-cleavage-at-the-h157-s158-bond-is-accelerated-for-the-alzheimer-s-disease-associated-h157y-variant
#11
Peter Thornton, Jean Sevalle, Michael J Deery, Graham Fraser, Ye Zhou, Sara Ståhl, Elske H Franssen, Roger B Dodd, Seema Qamar, Beatriz Gomez Perez-Nievas, Louise Sc Nicol, Susanna Eketjäll, Jefferson Revell, Clare Jones, Andrew Billinton, Peter H St George-Hyslop, Iain Chessell, Damian C Crowther
We have characterised the proteolytic cleavage events responsible for the shedding of triggering receptor expressed on myeloid cells 2 (TREM2) from primary cultures of human macrophages, murine microglia and TREM2-expressing human embryonic kidney (HEK293) cells. In all cell types, a soluble 17 kDa N-terminal cleavage fragment was shed into the conditioned media in a constitutive process that is inhibited by G1254023X and metalloprotease inhibitors and siRNA targeting ADAM10. Inhibitors of serine proteases and matrix metalloproteinases 2/9, and ADAM17 siRNA did not block TREM2 shedding...
October 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28843656/disease-outcomes-in-a-cohort-of-women-in-ireland-infected-by-hepatitis-c-contaminated-anti-d-immunoglobulin-during-1970s
#12
Patricia Garvey, Niamh Murphy, Paula Flanagan, Aline Brennan, Garry Courtney, Orla Crosbie, John Crowe, John Hegarty, John Lee, Margaret McIver, Carol McNulty, Frank Murray, Niamh Nolan, Cliona O'Farrelly, Stephen Stewart, Michele Tait, Suzanne Norris, Lelia Thornton
BACKGROUND & AIM: In the mid-1990s, a group of Rh negative women was diagnosed with hepatitis C virus (HCV) genotype 1b infection, following administration of contaminated anti-D immunoglobulin in 1977-79. We aimed to describe their disease history and estimate the effect of selected host and treatment factors on disease progression. METHODS: We conducted a cohort study on the women infected with HCV. Information was collected from records at seven HCV treatment centres on demographics, treatment and health outcomes up to the 31st December 2013...
August 24, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28819565/genomic-and-immune-heterogeneity-are-associated-with-differential-responses-to-therapy-in-melanoma
#13
Alexandre Reuben, Christine N Spencer, Peter A Prieto, Vancheswaran Gopalakrishnan, Sangeetha M Reddy, John P Miller, Xizeng Mao, Mariana Petaccia De Macedo, Jiong Chen, Xingzhi Song, Hong Jiang, Pei-Ling Chen, Hannah C Beird, Haven R Garber, Whijae Roh, Khalida Wani, Eveline Chen, Cara Haymaker, Marie-Andrée Forget, Latasha D Little, Curtis Gumbs, Rebecca L Thornton, Courtney W Hudgens, Wei-Shen Chen, Jacob Austin-Breneman, Robert Szczepaniak Sloane, Luigi Nezi, Alexandria P Cogdill, Chantale Bernatchez, Jason Roszik, Patrick Hwu, Scott E Woodman, Lynda Chin, Hussein Tawbi, Michael A Davies, Jeffrey E Gershenwald, Rodabe N Amaria, Isabella C Glitza, Adi Diab, Sapna P Patel, Jianhua Hu, Jeffrey E Lee, Elizabeth A Grimm, Michael T Tetzlaff, Alexander J Lazar, Ignacio I Wistuba, Karen Clise-Dwyer, Brett W Carter, Jianhua Zhang, P Andrew Futreal, Padmanee Sharma, James P Allison, Zachary A Cooper, Jennifer A Wargo
Appreciation for genomic and immune heterogeneity in cancer has grown though the relationship of these factors to treatment response has not been thoroughly elucidated. To better understand this, we studied a large cohort of melanoma patients treated with targeted therapy or immune checkpoint blockade (n = 60). Heterogeneity in therapeutic responses via radiologic assessment was observed in the majority of patients. Synchronous melanoma metastases were analyzed via deep genomic and immune profiling, and revealed substantial genomic and immune heterogeneity in all patients studied, with considerable diversity in T cell frequency, and few shared T cell clones (<8% on average) across the cohort...
2017: NPJ Genomic Medicine
https://www.readbyqxmd.com/read/28803915/neural-crest-cell-implantation-restores-enteric-nervous-system-function-and-alters-the-gastrointestinal-transcriptome-in-human-tissue-engineered-small-intestine
#14
Christopher R Schlieve, Kathryn L Fowler, Matthew Thornton, Sha Huang, Ibrahim Hajjali, Xiaogang Hou, Brendan Grubbs, Jason R Spence, Tracy C Grikscheit
Acquired or congenital disruption in enteric nervous system (ENS) development or function can lead to significant mechanical dysmotility. ENS restoration through cellular transplantation may provide a cure for enteric neuropathies. We have previously generated human pluripotent stem cell (hPSC)-derived tissue-engineered small intestine (TESI) from human intestinal organoids (HIOs). However, HIO-TESI fails to develop an ENS. The purpose of our study is to restore ENS components derived exclusively from hPSCs in HIO-TESI...
September 12, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28797323/hepatitis-c-virus-seroprevalence-and-prevalence-of-chronic-infection-in-the-adult-population-in-ireland-a-study-of-residual-sera-april-2014-to-february-2016
#15
Patricia Garvey, Brian O'Grady, Geraldine Franzoni, Maeve Bolger, Katie Irwin Crosby, Jeff Connell, Deirdre Burke, Cillian De Gascun, Lelia Thornton
Robust data on hepatitis C virus (HCV) population prevalence are essential to inform national HCV services. In 2016, we undertook a survey to estimate HCV prevalence among the adult population in Ireland. We used anonymised residual sera available at the National Virus Reference Laboratory. We selected a random sample comprising persons ≥ 18 years with probability proportional to the general population age-sex distribution. Anti-HCV and HCV Ag were determined using the Architect anti-HCV and HCV Ag assays...
July 27, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28783712/machine-learning-for-predicting-lifespan-extending-chemical-compounds
#16
Diogo G Barardo, Danielle Newby, Daniel Thornton, Taravat Ghafourian, João Pedro de Magalhães, Alex A Freitas
Increasing age is a risk factor for many diseases; therefore developing pharmacological interventions that slow down ageing and consequently postpone the onset of many age-related diseases is highly desirable. In this work we analyse data from the DrugAge database, which contains chemical compounds and their effect on the lifespan of model organisms. Predictive models were built using the machine learning method random forests to predict whether or not a chemical compound will increase Caenorhabditis elegans' lifespan, using as features Gene Ontology (GO) terms annotated for proteins targeted by the compounds and chemical descriptors calculated from each compound's chemical structure...
July 18, 2017: Aging
https://www.readbyqxmd.com/read/28776147/looming-threats-and-animacy-reduced-responsiveness-in-youth-with-disrupted-behavior-disorders
#17
Stuart F White, Laura C Thornton, Joseph Leshin, Roberta Clanton, Stephen Sinclair, Dionne Coker-Appiah, Harma Meffert, Soonjo Hwang, James R Blair
Theoretical models have implicated amygdala dysfunction in the development of Disruptive Behavior Disorders (DBDs; Conduct Disorder/Oppositional Defiant Disorder). Amygdala dysfunction impacts valence evaluation/response selection and emotion attention in youth with DBDs, particularly in those with elevated callous-unemotional (CU) traits. However, amygdala responsiveness during social cognition and the responsiveness of the acute threat circuitry (amygdala/periaqueductal gray) in youth with DBDs have been less well-examined, particularly with reference to CU traits...
August 3, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28775215/observation-of-coherent-elastic-neutrino-nucleus-scattering
#18
D Akimov, J B Albert, P An, C Awe, P S Barbeau, B Becker, V Belov, A Brown, A Bolozdynya, B Cabrera-Palmer, M Cervantes, J I Collar, R J Cooper, R L Cooper, C Cuesta, D J Dean, J A Detwiler, A Eberhardt, Y Efremenko, S R Elliott, E M Erkela, L Fabris, M Febbraro, N E Fields, W Fox, Z Fu, A Galindo-Uribarri, M P Green, M Hai, M R Heath, S Hedges, D Hornback, T W Hossbach, E B Iverson, L J Kaufman, S Ki, S R Klein, A Khromov, A Konovalov, M Kremer, A Kumpan, C Leadbetter, L Li, W Lu, K Mann, D M Markoff, K Miller, H Moreno, P E Mueller, J Newby, J L Orrell, C T Overman, D S Parno, S Penttila, G Perumpilly, H Ray, J Raybern, D Reyna, G C Rich, D Rimal, D Rudik, K Scholberg, B J Scholz, G Sinev, W M Snow, V Sosnovtsev, A Shakirov, S Suchyta, B Suh, R Tayloe, R T Thornton, I Tolstukhin, J Vanderwerp, R L Varner, C J Virtue, Z Wan, J Yoo, C-H Yu, A Zawada, J Zettlemoyer, A M Zderic
The coherent elastic scattering of neutrinos off nuclei has eluded detection for four decades, even though its predicted cross-section is the largest by far of all low-energy neutrino couplings. This mode of interaction provides new opportunities to study neutrino properties, and leads to a miniaturization of detector size, with potential technological applications. We observe this process at a 6.7-sigma confidence level, using a low-background, 14.6-kg CsI[Na] scintillator exposed to the neutrino emissions from the Spallation Neutron Source (SNS) at Oak Ridge National Laboratory...
August 3, 2017: Science
https://www.readbyqxmd.com/read/28771763/farmarel-an-italian-pharmacovigilance-project-to-monitor-and-evaluate-adverse-drug-reactions-in-haematologic-patients
#19
Nicola S Fracchiolla, Silvia Artuso, Agostino Cortelezzi, Anna M Pelizzari, Paola Tozzi, Maurizio Bonfichi, Federica Bocchio, Livio Gargantini, Elisa De Rosa, Giuseppe D Vighi, Lucia Prestini, Simona Sammassimo, Niccolò Frungillo, Maria C Pasquini, Alessandra Ragazzi, Daniele Boghi, Alessia Pastore, Eraldo Lanzi, Giuseppe Gritti, Giulia Quaresmini, Simone Voltolini, Roberta Gaiardoni, Consuelo Corti, Maria C Vilardo, Maria L La Targia, Giacomo Berini, Massimo Magagnoli, Claudia Bacci, Dario Consonni, Alma L Rivolta, Giuliana Muti
Adverse drug reactions (ADRs) reduce patients' quality of life, increase mortality and morbidity, and have a negative economic impact on healthcare systems. Nevertheless, the importance of ADR reporting is often underestimated. The project "FarmaREL" has been developed to monitor and evaluate ADRs in haematological patients and to increase pharmacovigilance culture among haematology specialists. In 13 haematology units, based in Lombardy, Italy, a dedicated specialist with the task of encouraging ADRs reporting and sensitizing healthcare professionals to pharmacovigilance has been assigned...
August 3, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/28767105/erratum-genetic-loci-associated-with-heart-rate-variability-and-their-effects-on-cardiac-disease-risk
#20
Ilja M Nolte, M Loretto Munoz, Vinicius Tragante, Azmeraw T Amare, Rick Jansen, Ahmad Vaez, Benedikt von der Heyde, Christy L Avery, Joshua C Bis, Bram Dierckx, Jenny van Dongen, Stephanie M Gogarten, Philippe Goyette, Jussi Hernesniemi, Ville Huikari, Shih-Jen Hwang, Deepali Jaju, Kathleen F Kerr, Alexander Kluttig, Bouwe P Krijthe, Jitender Kumar, Sander W van der Laan, Leo-Pekka Lyytikäinen, Adam X Maihofer, Arpi Minassian, Peter J van der Most, Martina Müller-Nurasyid, Michel Nivard, Erika Salvi, James D Stewart, Julian F Thayer, Niek Verweij, Andrew Wong, Delilah Zabaneh, Mohammad H Zafarmand, Abdel Abdellaoui, Sulayma Albarwani, Christine Albert, Alvaro Alonso, Foram Ashar, Juha Auvinen, Tomas Axelsson, Dewleen G Baker, Paul I W de Bakker, Matteo Barcella, Riad Bayoumi, Rob J Bieringa, Dorret Boomsma, Gabrielle Boucher, Annie R Britton, Ingrid Christophersen, Andrea Dietrich, George B Ehret, Patrick T Ellinor, Markku Eskola, Janine F Felix, John S Floras, Oscar H Franco, Peter Friberg, Maaike G J Gademan, Mark A Geyer, Vilmantas Giedraitis, Catharina A Hartman, Daiane Hemerich, Albert Hofman, Jouke-Jan Hottenga, Heikki Huikuri, Nina Hutri-Kähönen, Xavier Jouven, Juhani Junttila, Markus Juonala, Antti M Kiviniemi, Jan A Kors, Meena Kumari, Tatiana Kuznetsova, Cathy C Laurie, Joop D Lefrandt, Yong Li, Yun Li, Duanping Liao, Marian C Limacher, Henry J Lin, Cecilia M Lindgren, Steven A Lubitz, Anubha Mahajan, Barbara McKnight, Henriette Meyer Zu Schwabedissen, Yuri Milaneschi, Nina Mononen, Andrew P Morris, Mike A Nalls, Gerjan Navis, Melanie Neijts, Kjell Nikus, Kari E North, Daniel T O'Connor, Johan Ormel, Siegfried Perz, Annette Peters, Bruce M Psaty, Olli T Raitakari, Victoria B Risbrough, Moritz F Sinner, David Siscovick, Johannes H Smit, Nicholas L Smith, Elsayed Z Soliman, Nona Sotoodehnia, Jan A Staessen, Phyllis K Stein, Adrienne M Stilp, Katarzyna Stolarz-Skrzypek, Konstantin Strauch, Johan Sundström, Cees A Swenne, Ann-Christine Syvänen, Jean-Claude Tardif, Kent D Taylor, Alexander Teumer, Timothy A Thornton, Lesley E Tinker, André G Uitterlinden, Jessica van Setten, Andreas Voss, Melanie Waldenberger, Kirk C Wilhelmsen, Gonneke Willemsen, Quenna Wong, Zhu-Ming Zhang, Alan B Zonderman, Daniele Cusi, Michele K Evans, Halina K Greiser, Pim van der Harst, Mohammad Hassan, Erik Ingelsson, Marjo-Riitta Järvelin, Stefan Kääb, Mika Kähönen, Mika Kivimaki, Charles Kooperberg, Diana Kuh, Terho Lehtimäki, Lars Lind, Caroline M Nievergelt, Chris J O'Donnell, Albertine J Oldehinkel, Brenda Penninx, Alexander P Reiner, Harriëtte Riese, Arie M van Roon, John D Rioux, Jerome I Rotter, Tamar Sofer, Bruno H Stricker, Henning Tiemeier, Tanja G M Vrijkotte, Folkert W Asselbergs, Bianca J J M Brundel, Susan R Heckbert, Eric A Whitsel, Marcel den Hoed, Harold Snieder, Eco J C de Geus
This corrects the article DOI: 10.1038/ncomms15805.
August 2, 2017: Nature Communications
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