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Thornton, C

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https://www.readbyqxmd.com/read/27936421/catheter-directed-endovascular-application-of-thrombin-report-of-3-cases-and-review-of-the-literature
#1
Majid Maybody, David C Madoff, Raymond H Thornton, Steven A Morales, Chaya S Moskowitz, Meier Hsu, Lynn A Brody, Karen T Brown, Anne M Covey
PURPOSE: To report 3 new cases of catheter-directed endovascular application of thrombin and explore trends by analysis of published case series. MATERIALS AND METHODS: Institutional Review Board approved this retrospective study. All cases of non-tumoral arterial embolization performed from January 2003 to January 2015 at our institution were retrospectively reviewed. Thrombin was used in 7 of 589 cases. In 3 cases intra arterial thrombin was injected via catheter to treat active hemorrhage...
November 29, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27932298/modeling-birds-on-wires
#2
A Aydoğdu, P Frasca, C D'Apice, R Manzo, J M Thornton, B Gachomo, T Wilson, B Cheung, U Tariq, W Saidel, B Piccoli
In this paper we introduce a mathematical model to study the group dynamics of birds resting on wires. The model is agent-based and postulates attraction-repulsion forces between the interacting birds: the interactions are "topological", in the sense that they involve a given number of neighbors irrespective of their distance. The model is first mathematically analyzed and then simulated to study its main properties: we observe that the model predicts birds to be more widely spaced near the borders of each group...
December 5, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/27917982/climate-change-and-pastoralism-impacts-consequences-and-adaptation
#3
M Herrero, J Addison, C Bedelian, E Carabine, P Havlík, B Henderson, J Van De Steeg, P K Thornton
The authors discuss the main climate change impacts on pastoralist societies, including those on rangelands, livestock and other natural resources, and their extended repercussions on food security, incomes and vulnerability. The impacts of climate change on the rangelands of the globe and on the vulnerability of the people who inhabit them will be severe and diverse, and will require multiple, simultaneous responses. In higher latitudes, the removal of temperature constraints might increase pasture production and livestock productivity, but in tropical arid lands, the impacts are highly location specific, but mostly negative...
November 2016: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/27902640/minimal-endoillumination-levels-and-display-luminous-emittance-during-three-dimensional-heads-up-vitreoretinal-surgery
#4
Murtaza K Adam, Sarah Thornton, Carl D Regillo, Carl Park, Allen C Ho, Jason Hsu
PURPOSE: To determine minimal endoillumination levels required to perform 3-dimensional heads-up vitreoretinal surgery and to correlate endoillumination levels used for measurements of heads-up display (HUD) luminous emittance. METHODS: Prospective, observational surgical case series of 10 patients undergoing vitreoretinal surgery. Endoillumination levels were set to 40% of maximum output and were decreased at set intervals until the illumination level was 0%. Corresponding luminous emittance (lux) of the HUD was measured 40 cm from the display using a luxmeter (Dr...
November 29, 2016: Retina
https://www.readbyqxmd.com/read/27872893/response-to-sunitinib-sutent-in-chemotherapy-refractory-clear-cell-ovarian-cancer
#5
C Alifrangis, A Thornton, C Fotopoulou, J Krell, H Gabra
•Case describes a response to sunitinib in clear cell ovarian cancer.•Discussion of unique molecular characteristics of clear cell ovarian cancers•Practical points regarding dosing and toxicity when using sunitinib discussed.
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27870227/aspergillosis-and-the-role-of-mucins-in-cystic-fibrosis
#6
REVIEW
Abigail C Cowley, David J Thornton, David W Denning, Alexander Horsley
The prevalence of aspergillosis in CF patients has until recently been underestimated, but increasing evidence suggests that it may play an important role in the progression of CF lung disease. In healthy airways, Aspergillus fumigatus can be efficiently removed from the lung by mechanisms such as mucociliary clearance and cough. However, these mechanisms are defective in CF, allowing pathogens such as A. fumigatus to germinate and establish chronic infections within the airways. The precise means by which A...
November 21, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27857076/3d-visualization-of-additive-occlusion-and-tunable-full-spectrum-fluorescence-in-calcite
#7
David C Green, Johannes Ihli, Paul D Thornton, Mark A Holden, Bartosz Marzec, Yi-Yeoun Kim, Alex N Kulak, Mark A Levenstein, Chiu Tang, Christophe Lynch, Stephen E D Webb, Christopher J Tynan, Fiona C Meldrum
From biomineralization to synthesis, organic additives provide an effective means of controlling crystallization processes. There is growing evidence that these additives are often occluded within the crystal lattice. This promises an elegant means of creating nanocomposites and tuning physical properties. Here we use the incorporation of sulfonated fluorescent dyes to gain new understanding of additive occlusion in calcite (CaCO3), and to link morphological changes to occlusion mechanisms. We demonstrate that these additives are incorporated within specific zones, as defined by the growth conditions, and show how occlusion can govern changes in crystal shape...
November 18, 2016: Nature Communications
https://www.readbyqxmd.com/read/27831803/measuring-airway-mucin-2-in-patients-with-severe-chronic-obstructive-pulmonary-disease-with-bacterial-colonization
#8
Burton F Dickey, John V Fahy, Mehmet Kesimer, Richard C Boucher, Christopher M Evans, David Thornton
No abstract text is available yet for this article.
November 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27829373/pyruvate-oxidase-of-streptococcus-pneumoniae-contributes-to-pneumolysin-release
#9
Joseph C Bryant, Ridge C Dabbs, Katie L Oswalt, Lindsey R Brown, Jason W Rosch, Keun S Seo, Janet R Donaldson, Larry S McDaniel, Justin A Thornton
BACKGROUND: Streptococcus pneumoniae is one of the leading causes of community acquired pneumonia and acute otitis media. Certain aspects of S. pneumoniae's virulence are dependent upon expression and release of the protein toxin pneumolysin (PLY) and upon the activity of the peroxide-producing enzyme, pyruvate oxidase (SpxB). We investigated the possible synergy of these two proteins and identified that release of PLY is enhanced by expression of SpxB prior to stationary phase growth...
November 9, 2016: BMC Microbiology
https://www.readbyqxmd.com/read/27808013/paternal-age-at-childbirth-and-eating-disorders-in-offspring
#10
K N Javaras, M E Rickert, L M Thornton, C M Peat, J H Baker, A Birgegård, C Norring, M Landén, C Almqvist, H Larsson, P Lichtenstein, C M Bulik, B M D'Onofrio
BACKGROUND: Advanced paternal age at childbirth is associated with psychiatric disorders in offspring, including schizophrenia, bipolar disorder and autism. However, few studies have investigated paternal age's relationship with eating disorders in offspring. In a large, population-based cohort, we examined the association between paternal age and offspring eating disorders, and whether that association remains after adjustment for potential confounders (e.g. parental education level) that may be related to late/early selection into fatherhood and to eating disorder incidence...
November 3, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27791356/the-secondary-structure-and-glycosylation-of-mucus-glycoproteins-by-raman-spectroscopies
#11
Heather S Davies, Prabha Singh, Tanja Deckert-Gaudig, Volker Deckert, Karine Rousseau, Caroline E Ridley, Sarah E Dowd, Andrew James Doig, Paul D A Pudney, David J Thornton, Ewan W Blanch
The major structural components of protective mucus hydrogels on mucosal surfaces are the secreted polymeric gel-forming mucins. The very high molecular weight and extensive O-glycosylation of gel-forming mucins, which are key to their vis-coelastic properties, create problems when studying mucins using conventional biochemical/structural techniques. Thus, key structural information, such as the secondary structure of the various mucin subdomains, and glycosylation patterns along individual molecules, remains to be elucidated...
October 28, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27782608/a-compact-low-cost-marx-bank-for-generating-capillary-discharge-plasmas
#12
A E Dyson, C Thornton, S M Hooker
We describe in detail a low power Compact Marx Bank (CMB) circuit that can provide 20 kV, 500 A pulses of approximately 100-200 ns duration. One application is the generation of capillary discharge plasmas of density ≈10(18) cm(-3) used in laser plasma accelerators. The CMB is triggered with a high speed solid state switch and gives a high voltage output pulse with a ns scale rise time into a 50 Ω load (coaxial cable) with <4 ns voltage jitter. Its small size (10 cm  ×  25 cm  ×  5 cm) means that it can be placed right next to the capillary discharge in the target chamber to avoid the need to impedance match...
September 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27750294/chronic-hepatitis-b-and-c-virus-infection-and-risk-for-non-hodgkin-lymphoma-in-hiv-infected-patients-a-cohort-study
#13
Qing Wang, Andrea De Luca, Colette Smith, Robert Zangerle, Helen Sambatakou, Fabrice Bonnet, Colette Smit, Philipp Schommers, Alicia Thornton, Juan Berenguer, Lars Peters, Vincenzo Spagnuolo, Adriana Ammassari, Andrea Antinori, Eugenia Quiros Roldan, Cristina Mussini, Jose M Miro, Deborah Konopnicki, Jan Fehr, Maria A Campbell, Monique Termote, Heiner C Bucher
Background: Non-Hodgkin lymphoma (NHL) is the most common AIDS-defining condition in the era of antiretroviral therapy (ART). Whether chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection promote NHL in HIV-infected patients is unclear. Objective: To investigate whether chronic HBV and HCV infection are associated with increased incidence of NHL in HIV-infected patients. Design: Cohort study. Setting: 18 of 33 cohorts from the Collaboration of Observational HIV Epidemiological Research Europe (COHERE)...
October 18, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27748621/callous-unemotional-traits-predict-self-reported-offending-in-adolescent-boys-the-mediating-role-of-delinquent-peers-and-the-moderating-role-of-parenting-practices
#14
James V Ray, Paul J Frick, Laura C Thornton, Tina D Wall Myers, Laurence Steinberg, Elizabeth Cauffman
Research has only recently begun to examine how callous-unemotional (CU) traits interact with contextual factors to predict delinquent behavior. The current study attempts to explain the well-established link between CU traits and offending by testing the potential mediating and moderating roles of 2 critical contextual factors: peer delinquency and the quality of the parent-adolescent relationship among a sample of 1,216 male juvenile offenders. Youth in the study were interviewed once every 6 months and in the current analyses, CU traits measured at baseline, parenting and delinquent peer association measured during the 6-month interview, and offending measured at the 1-year interview were utilized in path analysis...
October 17, 2016: Developmental Psychology
https://www.readbyqxmd.com/read/27742226/equivalent-decline-in-inflammation-markers-with-tenofovir-disoproxil-fumarate-vs-tenofovir-alafenamide
#15
Nicholas T Funderburg, Grace A McComsey, Manjusha Kulkarni, Tammy Bannerman, Jessica Mantini, Bernadette Thornton, Hui C Liu, Yafeng Zhang, Qinghua Song, Liang Fang, Jason Dinoso, Andrew Cheng, Scott McCallister, Marshall W Fordyce, Moupali Das
BACKGROUND: Initiation of antiretroviral therapy (ART) and subsequent virologic suppression reduces immune activation and systemic inflammation. METHODS: We examined longitudinal changes in biomarkers of monocyte activation (sCD14, sCD163), and systemic (IL-6, hsCRP, sTNFR-I and D-dimer) and vascular (Lp-PLA2) inflammation in a subgroup (N=100 per arm) of participants enrolled in a randomized, placebo-controlled trial comparing elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF; TAF) to E/C/F/tenofovir disoproxil fumarate (E/C/F/TDF; TDF) in treatment-naïve adults...
October 11, 2016: EBioMedicine
https://www.readbyqxmd.com/read/27716545/youth-with-substance-abuse-histories-exhibit-dysfunctional-representation-of-expected-value-during-a-passive-avoidance-task
#16
Stuart F White, Patrick Tyler, Mary L Botkin, Anna K Erway, Laura C Thornton, Venkata Kolli, Kayla Pope, Harma Meffert, R James Blair
Individuals with substance abuse (SA) histories show impairment in the computations necessary for decision-making, including expected value (EV) and prediction error (PE). Neuroimaging findings, however, have been inconsistent. Sixteen youth with (SApositive) and 29 youth without (SAnegative) substance abuse histories completed a passive avoidance task while undergoing functional MRI. The groups did not significantly differ on age, gender composition or IQ. Behavioral results indicated that SApositive youth showed significantly less learning than SAnegative youth over the task...
November 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27714955/restricting-dietary-sodium-reduces-plasma-sodium-response-to-exercise-in-the-heat
#17
E E Koenders, C P G Franken, J D Cotter, S N Thornton, N J Rehrer
Exercise-associated hyponatremia can be life-threatening. Excessive hypotonic fluid ingestion is the primary etiological factor but does not explain all variability. Possible effects of chronic sodium intake are unknown. The aim of this study was to determine whether dietary sodium affects plasma sodium concentration [Na(+) ] during exercise in the heat, when water intake nearly matches mass loss. Endurance-trained men (n = 9) participated in this crossover experiment. Each followed a low-sodium (lowNa) or high-sodium (highNa) diet for 9 days with 24-h fluid intakes and urine outputs measured before experimental trials (day 10)...
October 7, 2016: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/27709630/myeloid-derived-suppressor-cell-like-fibrocytes-are-increased-and-associated-with-preserved-lung-function-in-chronic-obstructive-pulmonary-disease
#18
A K A Wright, C Newby, R A Hartley, V Mistry, S Gupta, R Berair, K M Roach, R Saunders, T Thornton, M Shelley, K Edwards, B Barker, C E Brightling
BACKGROUND: The role of fibrocytes in chronic obstructive pulmonary disease (COPD) is unknown. We sought to enumerate blood and tissue fibrocytes in COPD and determine the association of blood fibrocytes with clinical features of disease. METHODS: Utilizing flow cytometry to identify circulating, collagen type 1(+) cells, we found two populations: (i) CD45(+) CD34(+) (fibrocytes) and (ii) CD45(+) CD34(-) [myeloid-derived suppressor cell (MDSC)-like fibrocytes] cells in stable COPD (n = 41) and control (n = 29) subjects...
October 6, 2016: Allergy
https://www.readbyqxmd.com/read/27690180/exopolymer-production-as-a-function-of-cell-permeability-and-death-in-a-diatom-thalassiosira-weissflogii-and-a-cyanobacterium-synechococcus-elongatus
#19
Daniel C O Thornton, Jie Chen
Exopolymer particles are found throughout the ocean and play a significant biogeochemical role in carbon cycling. Transparent exopolymer particles (TEP) are composed of acid polysaccharides and Coomassie staining particles (CSP) are proteins. TEP have been extensively studied in the ocean, while CSP have been largely overlooked. The objective of this research was to determine the role of stress and cell permeability in the formation of TEP and CSP. The diatom Thalassiosira weissflogii and cyanobacterium Synechococcus elongatus were grown in batch cultures and exposed to hydrogen peroxide (0, 10, and 100 μM) as an environmental stressor...
September 30, 2016: Journal of Phycology
https://www.readbyqxmd.com/read/27680568/physical-activity-in-older-adults-an-ecological-approach
#20
Christina M Thornton, Jacqueline Kerr, Terry L Conway, Brian E Saelens, James F Sallis, David K Ahn, Lawrence D Frank, Kelli L Cain, Abby C King
BACKGROUND: Studies identifying correlates of physical activity (PA) at all levels of the ecological model can provide an empirical basis for designing interventions to increase older adults' PA. PURPOSE: Applying ecological model principles, this study concurrently examined individual, psychosocial, and environmental correlates of older adults' PA to determine whether built environment factors contribute to PA over and above individual/demographic and psychosocial variables...
September 28, 2016: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
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