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Thornton, C

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https://www.readbyqxmd.com/read/29449513/adolescents-and-young-adults-with-a-rare-cancer-getting-past-semantics-to-optimal-care-for-patients-with-germ-cell-tumors
#1
Sara J Stoneham, Juliet P Hale, Carlos Rodriguez-Galindo, Ha Dang, Thomas Olson, Matthew Murray, James F Amatruda, Claire Thornton, G Suren Arul, Deborah Billmire, Mark Krailo, Dan Stark, Al Covens, Jean Hurteau, Sally Stenning, James C Nicholson, David Gershenson, A Lindsay Frazier
No abstract text is available yet for this article.
February 2018: Oncologist
https://www.readbyqxmd.com/read/29440393/granule-stored-muc5b-mucins-are-packed-by-the-non-covalent-formation-of-n-terminal-head-to-head-tetramers
#2
Sergio Trillo-Muyo, Harriet E Nilsson, Christian V Recktenwald, Anna Ermund, Caroline Ridley, Lauren N Meiss, Andrea Bahr, Nikolai Klymiuk, Jeffrey J Wine, Philip J Koeck, David J Thornton, Hans Hebert, Gunnar C Hansson
Most MUC5B mucin polymers in the upper airways of humans and pigs are produced by submucosal glands. MUC5B forms N-terminal covalent dimers, which are further packed into larger assemblies because of low pH and high Ca2+ in the secretory granule of the mucin-producing cell. We purified the recombinant MUC5B N-terminal covalent dimer and used single-particle electron microscopy to study its structure under intracellular conditions. We found that at intragranular pH, the dimeric MUC5B organized into head-to-head noncovalent tetramers where the von Willebrand D1-D2 domains hooked into each other...
February 13, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29428004/moderation-of-prior-exposure-to-trauma-on-the-inverse-relationship-between-callous-unemotional-traits-and-amygdala-responses-to-fearful-expressions-an-exploratory-study
#3
Harma Meffert, Laura C Thornton, Patrick M Tyler, Mary L Botkin, Anna K Erway, Venkata Kolli, Kayla Pope, Stuart F White, R James R Blair
BACKGROUND: Previous work has shown that amygdala responsiveness to fearful expressions is inversely related to level of callous-unemotional (CU) traits (i.e. reduced guilt and empathy) in youth with conduct problems. However, some research has suggested that the relationship between pathophysiology and CU traits may be different in those youth with significant prior trauma exposure. METHODS: In experiment 1, 72 youth with varying levels of disruptive behavior and trauma exposure performed a gender discrimination task while viewing morphed fear expressions (0, 50, 100, 150 fear) and Blood Oxygenation Level Dependent responses were recorded...
February 12, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29419378/does-ursodeoxycholic-acid-improve-perinatal-outcomes-in-women-with-intrahepatic-cholestasis-of-pregnancy
#4
Lucy C Chappell, Jenny Chambers, Jim G Thornton, Catherine Williamson
No abstract text is available yet for this article.
February 1, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29402235/what-gives-rise-to-clinician-gut-feeling-its-influence-on-management-decisions-and-its-prognostic-value-for-children-with-rti-in-primary-care-a-prospective-cohort-study
#5
Sophie Turnbull, Patricia J Lucas, Niamh M Redmond, Hannah Christensen, Hannah Thornton, Christie Cabral, Peter S Blair, Brendan C Delaney, Matthew Thompson, Paul Little, Tim J Peters, Alastair D Hay
BACKGROUND: The objectives were to identify 1) the clinician and child characteristics associated with; 2) clinical management decisions following from, and; 3) the prognostic value of; a clinician's 'gut feeling something is wrong' for children presenting to primary care with acute cough and respiratory tract infection (RTI). METHODS: Multicentre prospective cohort study where 518 primary care clinicians across 244 general practices in England assessed 8394 children aged ≥3 months and < 16 years for acute cough and RTI...
February 5, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29359740/the-germination-of-germanium
#6
Shawn C Burdette, Brett F Thornton
No abstract text is available yet for this article.
January 23, 2018: Nature Chemistry
https://www.readbyqxmd.com/read/29351125/central-inhibition-of-granulocyte-macrophage-colony-stimulating-factor-is-analgesic-in-experimental-neuropathic-pain
#7
Louise S C Nicol, Peter Thornton, Jon P Hatcher, Colin P Glover, Carl I Webster, Matthew Burrell, Kessia Hammett, Clare A Jones, Matthew A Sleeman, Andrew Billinton, Iain Chessell
With less than 50% of patients responding to the current standard of care and poor efficacy and selectivity of current treatments, neuropathic pain continues to be an area of considerable unmet medical need. Biological therapeutics such as monoclonal antibodies (mAbs) provide better intrinsic selectivity; however, delivery to the central nervous system (CNS) remains a challenge. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is well described in inflammation-induced pain, and early-phase clinical trials evaluating its antagonism have exemplified its importance as a peripheral pain target...
January 16, 2018: Pain
https://www.readbyqxmd.com/read/29341755/excitation-and-control-of-plasma-wakefields-by-multiple-laser-pulses
#8
J Cowley, C Thornton, C Arran, R J Shalloo, L Corner, G Cheung, C D Gregory, S P D Mangles, N H Matlis, D R Symes, R Walczak, S M Hooker
We demonstrate experimentally the resonant excitation of plasma waves by trains of laser pulses. We also take an important first step to achieving an energy recovery plasma accelerator by showing that a plasma wave can be damped by an out-of-resonance trailing laser pulse. The measured laser wakefields are found to be in excellent agreement with analytical and numerical models of wakefield excitation in the linear regime. Our results indicate a promising direction for achieving highly controlled, GeV-scale laser-plasma accelerators operating at multikilohertz repetition rates...
July 28, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29341121/violence-guns-and-suicide-in-new-orleans-results-from-a-qualitative-study-of-recent-suicide-decedents
#9
Rajeev Ramchand, Enchanté Franklin, Elizabeth Thornton, Sarah M Deland, Jeffrey C Rouse
Many Americans own guns to protect themselves against other people, but there is evidence that both victimization and gun access increase suicide risk. We conducted qualitative interviews with informants of 17 suicide cases in New Orleans of the 60 who died between January 2015 and April 2016 to understand the relationship between past trauma, gun access and storage, and suicide. Nine cases had experienced a past trauma, including three who had recently had a family member killed by homicide. Eight died via firearm; of those, seven owned the guns they used to take their lives and stored them locked (but loaded) at home or in their cars...
January 16, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29340302/localized-concentration-reversal-of-lithium-during-intercalation-into-nanoparticles
#10
Wei Zhang, Hui-Chia Yu, Lijun Wu, Hao Liu, Aziz Abdellahi, Bao Qiu, Jianming Bai, Bernardo Orvananos, Fiona C Strobridge, Xufeng Zhou, Zhaoping Liu, Gerbrand Ceder, Yimei Zhu, Katsuyo Thornton, Clare P Grey, Feng Wang
Nanoparticulate electrodes, such as Li x FePO4, have unique advantages over their microparticulate counterparts for the applications in Li-ion batteries because of the shortened diffusion path and access to nonequilibrium routes for fast Li incorporation, thus radically boosting power density of the electrodes. However, how Li intercalation occurs locally in a single nanoparticle of such materials remains unresolved because real-time observation at such a fine scale is still lacking. We report visualization of local Li intercalation via solid-solution transformation in individual Li x FePO4 nanoparticles, enabled by probing sub-angstrom changes in the lattice spacing in situ...
January 2018: Science Advances
https://www.readbyqxmd.com/read/29335461/pixelated-spatial-gene-expression-analysis-from-tissue
#11
A Ganguli, A Ornob, N Spegazzini, Y Liu, G Damhorst, T Ghonge, B Thornton, C J Konopka, W Dobrucki, S E Clare, R Bhargava, A M Smith, F Kosari, R Bashir
Here, we present a technique that performs on-chip picoliter real-time reverse transcriptase loop mediated isothermal amplification (RT-LAMP) reactions on a histological tissue section without any analyte purification while preserving the native spatial location of the nucleic acid molecules. We demonstrate this method by amplifying TOP2A messenger RNA (mRNA) in a prostate cancer xenograft with 100 µm spatial resolution and by visualizing the variation in threshold time of amplification across the tissue...
January 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29244949/growth-kinetics-and-size-distribution-dynamics-of-viscous-secondary-organic-aerosol
#12
Rahul A Zaveri, John E Shilling, Alla Zelenyuk, Jiumeng Liu, David M Bell, Emma L D'Ambro, Cassandra J Gaston, Joel A Thornton, Alexander Laskin, Peng Lin, Jacqueline M Wilson, Richard C Easter, Jian Wang, Allan K Bertram, Scot T Martin, John H Seinfeld, Douglas R Worsnop
Low bulk diffusivity inside viscous semisolid atmospheric secondary organic aerosol (SOA) can prolong equilibration timescale, but its broader impacts on aerosol growth and size distribution dynamics are poorly understood. Here we present quantitative insights into the effects of bulk diffusivity on the growth and evaporation kinetics of SOA formed under dry conditions from photooxidation of isoprene in the presence of a bimodal aerosol consisting of Aitken (ammonium sulfate) and accumulation (isoprene or -pinene SOA) mode particles...
December 15, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29236522/risky-sex-drugs-sensation-seeking-and-callous-unemotional-traits-in-justice-involved-male-adolescents
#13
Laura C Thornton, Paul J Frick, James V Ray, Tina D Wall Myers, Laurence Steinberg, Elizabeth Cauffman
The current study examined whether callous-unemotional (CU) traits predicted risky sexual behavior (i.e., unprotected sex, casual sex) and whether substance use and sensation seeking mediated this relationship over 24 months in justice-involved young men. Participants (N = 1,216) were an ethnically and racially diverse sample (46.3% White Latino, 38% Black, 15.7% White non-Latino) of first-time offending male adolescents (ages 13-17 years) from 3 U.S. cities. Participants completed 5 self-reported interviews at 6-month intervals over 2 years...
December 13, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/29235670/presumptive-migrating-gall-bladder-mucocoele-in-two-dogs-with-gall-bladder-rupture
#14
R K Burchell, L Thornton, C K Lim, M Murakami, Y Nakamura, A Gal
A 10-year-old neutered female soft-coated wheaten terrier and a 10-year-old, entire female Pomeranian were presented for vomiting and anorexia. Using ultrasound, an oval structure with a stellate, kiwifruit-like appearance typical of a gall bladder mucocoele was observed in the caudal abdomen of the soft-coated wheaten terrier and adjacent to the liver in the Pomeranian. There was also a moderate volume of abdominal effusion in both dogs. Cytology of the peritoneal fluid indicated a sterile exudative process but varied between the two dogs, with an absence of bile pigment in the soft-coated wheaten terrier and marked bile peritonitis in the Pomeranian...
December 13, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29227310/preoperative-risk-assessment-of-respiratory-failure
#15
Erika L Brinson, Kevin C Thornton
No abstract text is available yet for this article.
2018: International Anesthesiology Clinics
https://www.readbyqxmd.com/read/29211753/response-of-pumas-puma-concolor-to-migration-of-their-primary-prey-in-patagonia
#16
Maria L Gelin, Lyn C Branch, Daniel H Thornton, Andrés J Novaro, Matthew J Gould, Anthony Caragiulo
Large-scale ungulate migrations result in changes in prey availability for top predators and, as a consequence, can alter predator behavior. Migration may include entire populations of prey species, but often prey populations exhibit partial migration with some individuals remaining resident and others migrating. Interactions of migratory prey and predators have been documented in North America and some other parts of the world, but are poorly studied in South America. We examined the response of pumas (Puma concolor) to seasonal migration of guanacos (Lama guanicoe) in La Payunia Reserve in northern Patagonia Argentina, which is the site of the longest known ungulate migration in South America...
2017: PloS One
https://www.readbyqxmd.com/read/29196525/mapping-local-and-global-variability-in-plant-trait-distributions
#17
Ethan E Butler, Abhirup Datta, Habacuc Flores-Moreno, Ming Chen, Kirk R Wythers, Farideh Fazayeli, Arindam Banerjee, Owen K Atkin, Jens Kattge, Bernard Amiaud, Benjamin Blonder, Gerhard Boenisch, Ben Bond-Lamberty, Kerry A Brown, Chaeho Byun, Giandiego Campetella, Bruno E L Cerabolini, Johannes H C Cornelissen, Joseph M Craine, Dylan Craven, Franciska T de Vries, Sandra Díaz, Tomas F Domingues, Estelle Forey, Andrés González-Melo, Nicolas Gross, Wenxuan Han, Wesley N Hattingh, Thomas Hickler, Steven Jansen, Koen Kramer, Nathan J B Kraft, Hiroko Kurokawa, Daniel C Laughlin, Patrick Meir, Vanessa Minden, Ülo Niinemets, Yusuke Onoda, Josep Peñuelas, Quentin Read, Lawren Sack, Brandon Schamp, Nadejda A Soudzilovskaia, Marko J Spasojevic, Enio Sosinski, Peter E Thornton, Fernando Valladares, Peter M van Bodegom, Mathew Williams, Christian Wirth, Peter B Reich
Our ability to understand and predict the response of ecosystems to a changing environment depends on quantifying vegetation functional diversity. However, representing this diversity at the global scale is challenging. Typically, in Earth system models, characterization of plant diversity has been limited to grouping related species into plant functional types (PFTs), with all trait variation in a PFT collapsed into a single mean value that is applied globally. Using the largest global plant trait database and state of the art Bayesian modeling, we created fine-grained global maps of plant trait distributions that can be applied to Earth system models...
December 1, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29167452/cross-continental-increase-in-methane-ebullition-under-climate-change
#18
Ralf C H Aben, Nathan Barros, Ellen van Donk, Thijs Frenken, Sabine Hilt, Garabet Kazanjian, Leon P M Lamers, Edwin T H M Peeters, Jan G M Roelofs, Lisette N de Senerpont Domis, Susanne Stephan, Mandy Velthuis, Dedmer B Van de Waal, Martin Wik, Brett F Thornton, Jeremy Wilkinson, Tonya DelSontro, Sarian Kosten
Methane (CH4) strongly contributes to observed global warming. As natural CH4 emissions mainly originate from wet ecosystems, it is important to unravel how climate change may affect these emissions. This is especially true for ebullition (bubble flux from sediments), a pathway that has long been underestimated but generally dominates emissions. Here we show a remarkably strong relationship between CH4 ebullition and temperature across a wide range of freshwater ecosystems on different continents using multi-seasonal CH4 ebullition data from the literature...
November 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/29160927/climate-change-impacts-on-selected-global-rangeland-ecosystem-services
#19
Randall B Boone, Richard T Conant, Jason Sircely, Philip K Thornton, Mario Herrero
Rangelands are Earth's dominant land cover and are important providers of ecosystem services. Reliance on rangelands is projected to grow, thus understanding the sensitivity of rangelands to future climates is essential. We used a new ecosystem model of moderate complexity that allows, for the first time, to quantify global changes expected in rangelands under future climates. The mean global annual net primary production (NPP) may decline by 10 g C m(-2) yr(-1) in 2050 under Representative Concentration Pathway (RCP) 8...
November 21, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29160811/relationships-between-vacant-homes-and-food-swamps-a-longitudinal-study-of-an-urban-food-environment
#20
Yeeli Mui, Jessica C Jones-Smith, Rachel L J Thornton, Keshia Pollack Porter, Joel Gittelsohn
Research indicates that living in neighborhoods with high concentrations of boarded-up vacant homes is associated with premature mortality due to cancer and diabetes, but the mechanism for this relationship is unclear. Boarded-up housing may indirectly impact residents' health by affecting their food environment. We evaluated the association between changes in vacancy rates and changes in the density of unhealthy food outlets as a proportion of all food outlets, termed the food swamp index, in Baltimore, MD (USA) from 2001 to 2012, using neighborhood fixed-effects linear regression models...
November 21, 2017: International Journal of Environmental Research and Public Health
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