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Thornton, C

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https://www.readbyqxmd.com/read/29694148/first-measurement-of-monoenergetic-muon-neutrino-charged-current-interactions
#1
A A Aguilar-Arevalo, B C Brown, L Bugel, G Cheng, E D Church, J M Conrad, R L Cooper, R Dharmapalan, Z Djurcic, D A Finley, R S Fitzpatrick, R Ford, F G Garcia, G T Garvey, J Grange, W Huelsnitz, C Ignarra, R Imlay, R A Johnson, J R Jordan, G Karagiorgi, T Katori, T Kobilarcik, W C Louis, K Mahn, C Mariani, W Marsh, G B Mills, J Mirabal, C D Moore, J Mousseau, P Nienaber, B Osmanov, Z Pavlovic, D Perevalov, H Ray, B P Roe, A D Russell, M H Shaevitz, J Spitz, I Stancu, R Tayloe, R T Thornton, R G Van de Water, M O Wascko, D H White, D A Wickremasinghe, G P Zeller, E D Zimmerman
We report the first measurement of monoenergetic muon neutrino charged current interactions. MiniBooNE has isolated 236 MeV muon neutrino events originating from charged kaon decay at rest (K^{+}→μ^{+}ν_{μ}) at the NuMI beamline absorber. These signal ν_{μ}-carbon events are distinguished from primarily pion decay in flight ν_{μ} and ν[over ¯]_{μ} backgrounds produced at the target station and decay pipe using their arrival time and reconstructed muon energy. The significance of the signal observation is at the 3...
April 6, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29692293/understanding-the-link-between-exposure-to-violence-and-aggression-in-justice-involved-adolescents
#2
Tina D Wall Myers, Abigail Salcedo, Paul J Frick, James V Ray, Laura C Thornton, Laurence Steinberg, Elizabeth Cauffman
The current study advanced research on the link between community violence exposure and aggression by comparing the effects of violence exposure on different functions of aggression and by testing four potential (i.e., callous-unemotional traits, consideration of others, impulse control, and anxiety) mediators of this relationship. Analyses were conducted in an ethnically/racially diverse sample of 1,216 male first-time juvenile offenders (M = 15.30 years, SD = 1.29). Our results indicated that violence exposure had direct effects on both proactive and reactive aggression 18 months later...
May 2018: Development and Psychopathology
https://www.readbyqxmd.com/read/29674687/celecoxib-exerts-protective-effects-in-the-vascular-endothelium-via-cox-2-independent-activation-of-ampk-creb-nrf2-signalling
#3
Fahad Al-Rashed, Damien Calay, Marie Lang, Clare C Thornton, Andrea Bauer, Allan Kiprianos, Dorian O Haskard, Anusha Seneviratne, Joseph J Boyle, Alex H Schönthal, Caroline P Wheeler-Jones, Justin C Mason
Although concern remains about the athero-thrombotic risk posed by cyclo-oxygenase (COX)-2-selective inhibitors, recent data implicates rofecoxib, while celecoxib appears equivalent to NSAIDs naproxen and ibuprofen. We investigated the hypothesis that celecoxib activates AMP kinase (AMPK) signalling to enhance vascular endothelial protection. In human arterial and venous endothelial cells (EC), and in contrast to ibuprofen and naproxen, celecoxib induced the protective protein heme oxygenase-1 (HO-1). Celecoxib derivative 2,5-dimethyl-celecoxib (DMC) which lacks COX-2 inhibition also upregulated HO-1, implicating a COX-2-independent mechanism...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29674193/does-induction-of-labour-in-nulliparous-hypertensive-women-result-in-vaginal-birth-a-descriptive-study-utilising-birth-registry-data
#4
REVIEW
Charlene Eliza Thornton, Hannah Grace Dahlen, Annemarie Hennessy
BACKGROUND: Induction of labour (IOL) is a common procedure yet we have little information on the efficacy of the process for women with a hypertensive disorder of pregnancy (HDP). OBJECTIVE: To describe the birth type and associated factors in nulliparous HDP women undergoing an induction of labour. STUDY DESIGN: Statutorily collected datasets on every birth and hospital admission which occurred in the state of NSW Australia between the years 2000-2011 were analysed...
January 31, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29621281/evidence-of-functional-cell-mediated-immune-responses-to-nontypeable-haemophilus-influenzae-in-otitis-prone-children
#5
Elke Seppanen, Dino Tan, Karli J Corscadden, Andrew J Currie, Peter C Richmond, Ruth B Thornton, Lea-Ann S Kirkham
Otitis media (OM) remains a common paediatric disease, despite advances in vaccinology. Susceptibility to recurrent acute OM (rAOM) has been postulated to involve defective cell-mediated immune responses to common otopathogenic bacteria. We compared the composition of peripheral blood mononuclear cells (PBMC) from 20 children with a history of rAOM (otitis-prone) and 20 healthy non-otitis-prone controls, and assessed innate and cell-mediated immune responses to the major otopathogen nontypeable Haemophilus influenzae (NTHi)...
2018: PloS One
https://www.readbyqxmd.com/read/29590102/common-%C3%AE-globin-variants-modify-hematologic-and-other-clinical-phenotypes-in-sickle-cell-trait-and-disease
#6
Laura M Raffield, Jacob C Ulirsch, Rakhi P Naik, Samuel Lessard, Robert E Handsaker, Deepti Jain, Hyun M Kang, Nathan Pankratz, Paul L Auer, Erik L Bao, Joshua D Smith, Leslie A Lange, Ethan M Lange, Yun Li, Timothy A Thornton, Bessie A Young, Goncalo R Abecasis, Cathy C Laurie, Deborah A Nickerson, Steven A McCarroll, Adolfo Correa, James G Wilson, Guillaume Lettre, Vijay G Sankaran, Alex P Reiner
Co-inheritance of α-thalassemia has a significant protective effect on the severity of complications of sickle cell disease (SCD), including stroke. However, little information exists on the association and interactions for the common African ancestral α-thalassemia mutation (-α3.7 deletion) and β-globin traits (HbS trait [SCT] and HbC trait) on important clinical phenotypes such as red blood cell parameters, anemia, and chronic kidney disease (CKD). In a community-based cohort of 2,916 African Americans from the Jackson Heart Study, we confirmed the expected associations between SCT, HbC trait, and the -α3...
March 28, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29562132/design-of-bivalent-nucleic-acid-ligands-for-recognition-of-rna-repeated-expansion-associated-with-huntington-s-disease
#7
Shivaji Thadke, J Dinithi R Perera, V M Hridya, Kirti Bhatt, Ashif Yasin Shaikh, Wei-Che Hsieh, Mengshen David Chen, Chakicherla Gayathri, Roberto R Gil, Gordon S Rule, Arnab Mukherjee, Charles A Thornton, Danith H Ly
We report the development of a new class of nucleic acid ligands that is comprised of Janus bases and MPPNA backbone and is capable of binding rCAG-repeats in a sequence-specific and selective manner via, inference, bivalent H-bonding interactions. Individually, the interactions between ligands and RNA are weak and transient. However, upon the installation of C-terminal thioester and N-terminal cystine and the reduction of disulfide bond, they undergo template-directed native chemical ligation to form concatenated oligomeric products that bind tightly to the RNA template...
March 21, 2018: Biochemistry
https://www.readbyqxmd.com/read/29549211/role-of-viral-and-bacterial-pathogens-in-causing-pneumonia-among-western-australian-children-a-case-control-study-protocol
#8
Mejbah Uddin Bhuiyan, Thomas L Snelling, Rachel West, Jurissa Lang, Tasmina Rahman, Meredith L Borland, Ruth Thornton, Lea-Ann Kirkham, Chisha Sikazwe, Andrew C Martin, Peter C Richmond, David W Smith, Adam Jaffe, Christopher C Blyth
INTRODUCTION: Pneumonia is the leading cause of childhood morbidity and mortality globally. Introduction of the conjugate Haemophilus influenzae B and multivalent pneumococcal vaccines in developed countries including Australia has significantly reduced the overall burden of bacterial pneumonia. With the availability of molecular diagnostics, viruses are frequently detected in children with pneumonia either as primary pathogens or predispose to secondary bacterial infection. Many respiratory pathogens that are known to cause pneumonia are also identified in asymptomatic children, so the true contribution of these pathogens to childhood community-acquired pneumonia (CAP) remains unclear...
March 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29536040/a-metal-organic-framework-with-ultrahigh-glass-forming-ability
#9
Ang Qiao, Thomas D Bennett, Haizheng Tao, Andraž Krajnc, Gregor Mali, Cara M Doherty, Aaron W Thornton, John C Mauro, G Neville Greaves, Yuanzheng Yue
Glass-forming ability (GFA) is the ability of a liquid to avoid crystallization during cooling. Metal-organic frameworks (MOFs) are a new class of glass formers ( 1 - 3 ), with hitherto unknown dynamic and thermodynamic properties. We report the discovery of a new series of tetrahedral glass systems, zeolitic imidazolate framework-62 (ZIF-62) [Zn(Im2- x bIm x )], which have ultrahigh GFA, superior to any other known glass formers. This ultrahigh GFA is evidenced by a high viscosity η (105 Pa·s) at the melting temperature T m , a large crystal-glass network density deficit (Δρ/ρg )network , no crystallization in supercooled region on laboratory time scales, a low fragility ( m = 23), an extremely high Poisson's ratio (ν = 0...
March 2018: Science Advances
https://www.readbyqxmd.com/read/29535510/gene-expression-changes-in-knee-joint-tissues-with-aging-and-menopause-implications-for-the-joint-as-an-organ
#10
Natalie C Rollick, Devin B Lemmex, Yohei Ono, Carol R Reno, David A Hart, Ian Ky Lo, Gail M Thornton
Background: When considering the "joint as an organ", the tissues in a joint act as complementary components of an organ, and the "set point" is the cellular activity for homeostasis of the joint tissues. Even in the absence of injury, joint tissues have adaptive responses to processes, like aging and menopause, which result in changes to the set point. Purpose: The purpose of this study in a preclinical model was to investigate age-related and menopause-related changes in knee-joint tissues with the hypothesis that tissues will change in unique ways that reflect their differing contributions to maintaining joint function (as measured by joint laxity) and the differing processes of aging and menopause...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29522999/bacillus-licheniformis-in-geogenic-dust-induces-inflammation-in-respiratory-epithelium
#11
Janessa Pickering, Teck Hui Teo, Ruth B Thornton, Lea-Ann Kirkham, Graeme R Zosky, Holly D Clifford
Exposure to environmental geogenic (or earth-derived) dust can lead to more frequent and severe infections in the human airway. Particulate matter < 10 µm (PM10 ) is the component of air pollution that is commonly associated with the exacerbation of respiratory diseases. We have previously demonstrated that mice exposed to geogenic dust PM10 experienced an exacerbation of inflammatory responses to influenza A virus. Whether geogenic dust PM10 also exacerbates respiratory bacterial infection is not yet known, nor are the components of the dust that drive these responses...
March 6, 2018: Environmental Research
https://www.readbyqxmd.com/read/29521716/interprofessional-care-and-teamwork-in-the-icu
#12
Anne L Donovan, J Matthew Aldrich, A Kendall Gross, Denise M Barchas, Kevin C Thornton, Hildy M Schell-Chaple, Michael A Gropper, Angela K M Lipshutz
OBJECTIVES: We describe the importance of interprofessional care in modern critical care medicine. This review highlights the essential roles played by specific members of the interprofessional care team, including patients and family members, and discusses quality improvement initiatives that require interprofessional collaboration for success. DATA SOURCES: Studies were identified through MEDLINE search using a variety of search phrases related to interprofessional care, critical care provider types, and quality improvement initiatives...
March 7, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29507311/voxel-wise-comparisons-of-cellular-microstructure-and-diffusion-mri-in-mouse-hippocampus-using-3d-bridging-of-optically-clear-histology-with-neuroimaging-data-3d-bond
#13
H B Stolp, G Ball, P-W So, J-D Tournier, M Jones, C Thornton, A D Edwards
A key challenge in medical imaging is determining a precise correspondence between image properties and tissue microstructure. This comparison is hindered by disparate scales and resolutions between medical imaging and histology. We present a new technique, 3D Bridging of Optically-clear histology with Neuroimaging Data (3D-BOND), for registering medical images with 3D histology to overcome these limitations. Ex vivo 120 × 120 × 200 μm resolution diffusion-MRI (dMRI) data was acquired at 7 T from adult C57Bl/6 mouse hippocampus...
March 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29486463/genetic-variation-in-genes-underlying-diverse-dementias-may-explain-a-small-proportion-of-cases-in-the-alzheimer-s-disease-sequencing-project
#14
Elizabeth E Blue, Joshua C Bis, Michael O Dorschner, Debby W Tsuang, Sandra M Barral, Gary Beecham, Jennifer E Below, William S Bush, Mariusz Butkiewicz, Carlos Cruchaga, Anita DeStefano, Lindsay A Farrer, Alison Goate, Jonathan Haines, Jim Jaworski, Gyungah Jun, Brian Kunkle, Amanda Kuzma, Jenny J Lee, Kathryn L Lunetta, Yiyi Ma, Eden Martin, Adam Naj, Alejandro Q Nato, Patrick Navas, Hiep Nguyen, Christiane Reitz, Dolly Reyes, William Salerno, Gerard D Schellenberg, Sudha Seshadri, Harkirat Sohi, Timothy A Thornton, Otto Valadares, Cornelia van Duijn, Badri N Vardarajan, Li-San Wang, Eric Boerwinkle, Josée Dupuis, Margaret A Pericak-Vance, Richard Mayeux, Ellen M Wijsman
BACKGROUND/AIMS: The Alzheimer's Disease Sequencing Project (ADSP) aims to identify novel genes influencing Alzheimer's disease (AD). Variants within genes known to cause dementias other than AD have previously been associated with AD risk. We describe evidence of co-segregation and associations between variants in dementia genes and clinically diagnosed AD within the ADSP. METHODS: We summarize the properties of known pathogenic variants within dementia genes, describe the co-segregation of variants annotated as "pathogenic" in ClinVar and new candidates observed in ADSP families, and test for associations between rare variants in dementia genes in the ADSP case-control study...
February 27, 2018: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/29478905/mub-40-binds-to-lactoferrin-and-stands-as-a-specific-neutrophil-marker
#15
Mark C Anderson, Thibault Chaze, Yves-Marie Coïc, Louise Injarabian, Friederike Jonsson, Naelle Lombion, Dorothée Selimoglu-Buet, Judith Souphron, Caroline Ridley, Pascale Vonaesch, Bruno Baron, Ellen T Arena, Jean-Yves Tinevez, Giulia Nigro, Katharina Nothelfer, Eric Solary, Valérie Lapierre, Thierry Lazure, Mariette Matondo, David Thornton, Philippe J Sansonetti, Françoise Baleux, Benoit S Marteyn
Neutrophils represent the most abundant immune cells recruited to inflamed tissues. A lack of dedicated tools has hampered their detection and study. We show that a synthesized peptide, MUB40 , binds to lactoferrin, the most abundant protein stored in neutrophil-specific and tertiary granules. Lactoferrin is specifically produced by neutrophils among other leukocytes, making MUB40 a specific neutrophil marker. Naive mammalian neutrophils (human, guinea pig, mouse, rabbit) were labeled by fluorescent MUB40 conjugates (-Cy5, Dylight405)...
February 13, 2018: Cell Chemical Biology
https://www.readbyqxmd.com/read/29469957/the-effect-of-urine-concentration-and-ph-on-the-growth-of-escherichia-coli-in-canine-urine-in-vitro
#16
L A Thornton, R K Burchell, S E Burton, N Lopez-Villalobos, D Pereira, I MacEwan, C Fang, A C Hatmodjo, M A Nelson, A Grinberg, N Velathanthiri, A Gal
BACKGROUND: Lower urinary tract infections are common in dogs, and Escherichia coli is the most common bacterial pathogen isolated. The literature has conflicting evidence regarding the inhibitory effects of urine concentration and pH on E. coli growth. HYPOTHESIS/OBJECTIVES: To determine the effect of different pH and urine concentrations on E. coli growth in vitro. ANIMALS: Voided urine samples from 10 apparently healthy spayed female dogs were used...
February 22, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29464905/greater-neonatal-fat-free-mass-and-similar-fat-mass-following-a-randomized-trial-to-control-excess-gestational-weight-gain
#17
Dympna Gallagher, Barak Rosenn, Tatiana Toro-Ramos, Charles Paley, Sonia Gidwani, Michelle Horowitz, Janet Crane, Susan Lin, John C Thornton, Xavier Pi-Sunyer
OBJECTIVE: The objective of this study was to determine the effectiveness of controlling maternal gestational weight gain (GWG) in the second and third trimesters on neonate body composition. METHODS: Two hundred ten healthy women with overweight (25 > BMI < 30) or obesity (BMI ≥ 30) were randomly assigned to a lifestyle intervention (LI) program focused on controlling GWG through nutrition and activity behaviors or to usual obstetrical care (UC). Infant fat and fat-free mass (FFM) at birth were measured by using air displacement plethysmography (PEA POD) and by using quantitative magnetic resonance (QMR)...
March 2018: Obesity
https://www.readbyqxmd.com/read/29463838/interleukin-33-is-activated-by-allergen-and-necrosis-associated-proteolytic-activities-to-regulate-its-alarmin-activity-during-epithelial-damage
#18
Ian C Scott, Jayesh B Majithiya, Caroline Sanden, Peter Thornton, Philip N Sanders, Tom Moore, Molly Guscott, Dominic J Corkill, Jonas S Erjefält, E Suzanne Cohen
Interleukin (IL)-33 is an IL-1 family alarmin released from damaged epithelial and endothelial barriers to elicit immune responses and allergic inflammation via its receptor ST2. Serine proteases released from neutrophils, mast cells and cytotoxic lymphocytes have been proposed to process the N-terminus of IL-33 to enhance its activity. Here we report that processing of full length IL-33 can occur in mice deficient in these immune cell protease activities. We sought alternative mechanisms for the proteolytic activation of IL-33 and discovered that exogenous allergen proteases and endogenous calpains, from damaged airway epithelial cells, can process full length IL-33 and increase its alarmin activity up to ~60-fold...
February 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29449513/adolescents-and-young-adults-with-a-rare-cancer-getting-past-semantics-to-optimal-care-for-patients-with-germ-cell-tumors
#19
Sara J Stoneham, Juliet P Hale, Carlos Rodriguez-Galindo, Ha Dang, Thomas Olson, Matthew Murray, James F Amatruda, Claire Thornton, G Suren Arul, Deborah Billmire, Mark Krailo, Dan Stark, Al Covens, Jean Hurteau, Sally Stenning, James C Nicholson, David Gershenson, A Lindsay Frazier
No abstract text is available yet for this article.
February 2018: Oncologist
https://www.readbyqxmd.com/read/29440393/granule-stored-muc5b-mucins-are-packed-by-the-non-covalent-formation-of-n-terminal-head-to-head-tetramers
#20
Sergio Trillo-Muyo, Harriet E Nilsson, Christian V Recktenwald, Anna Ermund, Caroline Ridley, Lauren N Meiss, Andrea Bahr, Nikolai Klymiuk, Jeffrey J Wine, Philip J Koeck, David J Thornton, Hans Hebert, Gunnar C Hansson
Most MUC5B mucin polymers in the upper airways of humans and pigs are produced by submucosal glands. MUC5B forms N-terminal covalent dimers, which are further packed into larger assemblies because of low pH and high Ca2+ in the secretory granule of the mucin-producing cell. We purified the recombinant MUC5B N-terminal covalent dimer and used single-particle electron microscopy to study its structure under intracellular conditions. We found that at intragranular pH, the dimeric MUC5B organized into head-to-head noncovalent tetramers where the von Willebrand D1-D2 domains hooked into each other...
February 13, 2018: Journal of Biological Chemistry
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