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Thornton, C

Qing Wang, Andrea De Luca, Colette Smith, Robert Zangerle, Helen Sambatakou, Fabrice Bonnet, Colette Smit, Philipp Schommers, Alicia Thornton, Juan Berenguer, Lars Peters, Vincenzo Spagnuolo, Adriana Ammassari, Andrea Antinori, Eugenia Quiros Roldan, Cristina Mussini, Jose M Miro, Deborah Konopnicki, Jan Fehr, Maria A Campbell, Monique Termote, Heiner C Bucher
Background: Non-Hodgkin lymphoma (NHL) is the most common AIDS-defining condition in the era of antiretroviral therapy (ART). Whether chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection promote NHL in HIV-infected patients is unclear. Objective: To investigate whether chronic HBV and HCV infection are associated with increased incidence of NHL in HIV-infected patients. Design: Cohort study. Setting: 18 of 33 cohorts from the Collaboration of Observational HIV Epidemiological Research Europe (COHERE)...
October 18, 2016: Annals of Internal Medicine
James V Ray, Paul J Frick, Laura C Thornton, Tina D Wall Myers, Laurence Steinberg, Elizabeth Cauffman
Research has only recently begun to examine how callous-unemotional (CU) traits interact with contextual factors to predict delinquent behavior. The current study attempts to explain the well-established link between CU traits and offending by testing the potential mediating and moderating roles of 2 critical contextual factors: peer delinquency and the quality of the parent-adolescent relationship among a sample of 1,216 male juvenile offenders. Youth in the study were interviewed once every 6 months and in the current analyses, CU traits measured at baseline, parenting and delinquent peer association measured during the 6-month interview, and offending measured at the 1-year interview were utilized in path analysis...
October 17, 2016: Developmental Psychology
Nicholas T Funderburg, Grace A McComsey, Manjusha Kulkarni, Tammy Bannerman, Jessica Mantini, Bernadette Thornton, Hui C Liu, Yafeng Zhang, Qinghua Song, Liang Fang, Jason Dinoso, Andrew Cheng, Scott McCallister, Marshall W Fordyce, Moupali Das
BACKGROUND: Initiation of antiretroviral therapy (ART) and subsequent virologic suppression reduces immune activation and systemic inflammation. METHODS: We examined longitudinal changes in biomarkers of monocyte activation (sCD14, sCD163), and systemic (IL-6, hsCRP, sTNFR-I and D-dimer) and vascular (Lp-PLA2) inflammation in a subgroup (N=100 per arm) of participants enrolled in a randomized, placebo-controlled trial comparing elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF; TAF) to E/C/F/tenofovir disoproxil fumarate (E/C/F/TDF; TDF) in treatment-naïve adults...
October 11, 2016: EBioMedicine
Stuart F White, Patrick Tyler, Mary L Botkin, Anna K Erway, Laura C Thornton, Venkata Kolli, Kayla Pope, Harma Meffert, R James Blair
Individuals with substance abuse (SA) histories show impairment in the computations necessary for decision-making, including expected value (EV) and prediction error (PE). Neuroimaging findings, however, have been inconsistent. Sixteen youth with (SApositive) and 29 youth without (SAnegative) substance abuse histories completed a passive avoidance task while undergoing functional MRI. The groups did not significantly differ on age, gender composition or IQ. Behavioral results indicated that SApositive youth showed significantly less learning than SAnegative youth over the task...
September 21, 2016: Psychiatry Research
E E Koenders, C P G Franken, J D Cotter, S N Thornton, N J Rehrer
Exercise-associated hyponatremia can be life-threatening. Excessive hypotonic fluid ingestion is the primary etiological factor but does not explain all variability. Possible effects of chronic sodium intake are unknown. The aim of this study was to determine whether dietary sodium affects plasma sodium concentration [Na(+) ] during exercise in the heat, when water intake nearly matches mass loss. Endurance-trained men (n = 9) participated in this crossover experiment. Each followed a low-sodium (lowNa) or high-sodium (highNa) diet for 9 days with 24-h fluid intakes and urine outputs measured before experimental trials (day 10)...
October 7, 2016: Scandinavian Journal of Medicine & Science in Sports
A K A Wright, C Newby, R A Hartley, V Mistry, S Gupta, R Berair, K M Roach, R Saunders, T Thornton, M Shelley, K Edwards, B Barker, C E Brightling
BACKGROUND: The role of fibrocytes in COPD is unknown. We sought to enumerate blood and tissue fibrocytes in COPD and determine the association of blood fibrocytes with clinical features of disease. METHODS: Utilising flow cytometry to identify circulating, collagen type-1(+) cells we found two populations 1) CD45(+) CD34(+) (fibrocytes) and 2) CD45(+) CD34(-) (myeloid-derived suppressor cell [MDSC]-like fibrocytes) cells in stable COPD (n=41) and control (n=29) subjects...
October 6, 2016: Allergy
Daniel C O Thornton, Jie Chen
Exopolymer particles are found throughout the ocean and play a significant biogeochemical role in carbon cycling. Transparent exopolymer particles (TEP) are composed of acid polysaccharides and Coomassie staining particles (CSP) are proteins. TEP have been extensively studied in the ocean, while CSP have been largely overlooked. The objective of this research was to determine the role of stress and cell permeability in the formation of TEP and CSP. The diatom Thalassiosira weissflogii and cyanobacterium Synechococcus elongatus were grown in batch cultures and exposed to hydrogen peroxide (0, 10, and 100 μM) as an environmental stressor...
September 30, 2016: Journal of Phycology
Christina M Thornton, Jacqueline Kerr, Terry L Conway, Brian E Saelens, James F Sallis, David K Ahn, Lawrence D Frank, Kelli L Cain, Abby C King
BACKGROUND: Studies identifying correlates of physical activity (PA) at all levels of the ecological model can provide an empirical basis for designing interventions to increase older adults' PA. PURPOSE: Applying ecological model principles, this study concurrently examined individual, psychosocial, and environmental correlates of older adults' PA to determine whether built environment factors contribute to PA over and above individual/demographic and psychosocial variables...
September 28, 2016: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
C Shen, M Kummerlowe, C Morris, C Meyer, M Habibi, D A Frassica, A Levin, K Thornton, S A Terezakis
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Lahiru S Wijedasa, Jyrki Jauhiainen, Mari Könönen, Maija Lampela, Harri Vasander, Marie-Claire LeBlanc, Stephanie Evers, Thomas E L Smith, Catherine M Yule, Helena Varkkey, Massimo Lupascu, Faizal Parish, Ian Singleton, Gopalasamy R Clements, Sheema Abdul Aziz, Mark E Harrison, Susan Cheyne, Gusti Z Anshari, Erik Meijaard, Jenny E Goldstein, Susan Waldron, Kristell Hergoualc'h, René Dommain, Steve Frolking, Christopher D Evans, Mary Rose C Posa, Paul H Glaser, Nyoman Suryadiputra, Reza Lubis, Truly Santika, Rory Padfield, Sofyan Kurnianto, Panut Hadisiswoyo, Teck Wyn Lim, Susan E Page, Vincent Gauci, Peter J van der Meer, Helen Buckland, Fabien Garnier, Marshall K Samuel, Liza Nuriati Lim Kim Choo, Patrick O'Reilly, Matthew Warren, Surin Suksuwan, Elham Sumarga, Anuj Jain, William F Laurance, John Couwenberg, Hans Joosten, Ronald Vernimmen, Aljosja Hooijer, Chris Malins, Mark A Cochrane, Balu Perumal, Florian Siegert, Kelvin S-H Peh, Louis-Pierre Comeau, Louis Verchot, Charles F Harvey, Alex Cobb, Zeehan Jaafar, Henk Wösten, Solichin Manuri, Moritz Müller, Wim Giesen, Jacob Phelps, Ding Li Yong, Marcel Silvius, Béatrice M M Wedeux, Alison Hoyt, Mitsuru Osaki, Hirano Takashi, Hidenori Takahashi, Takashi S Kohyama, Akira Haraguchi, Nunung P Nugroho, David A Coomes, Le Phat Quoi, Alue Dohong, Haris Gunawan, David L A Gaveau, Andreas Langner, Felix K S Lim, David P Edwards, Xingli Giam, Guido van der Werf, Rachel Carmenta, Caspar C Verwer, Luke Gibson, Laure Grandois, Laura Linda Bozena Graham, Jhanson Regalino, Serge A Wich, Jack Rieley, Nicholas Kettridge, Chloe Brown, Romain Pirard, Sam Moore, B Ripoll Capilla, Uwe Ballhorn, Hua Chew Ho, Agata Hoscilo, Sandra Lohberger, Theodore A Evans, Nina Yulianti, Grace Blackham, Onrizal, Simon Husson, Daniel Murdiyarso, Sunita Pangala, Lydia E S Cole, Luca Tacconi, Hendrik Segah, Prayoto Tonoto, Janice S H Lee, Gerald Schmilewski, Stephan Wulffraat, Erianto Indra Putra, Megan E Cattau, R S Clymo, Ross Morrison, Aazani Mujahid, Jukka Miettinen, Soo Chin Liew, Samu Valpola, David Wilson, Laura D'Arcy, Michiel Gerding, Siti Sundari, Sara A Thornton, Barbara Kalisz, Stephen J Chapman, Ahmad Suhaizi Mat Su, Imam Basuki, Masayuki Itoh, Carl Traeholt, Sean Sloan, Alexander K Sayok, Roxane Andersen
The first International Peat Congress (IPC) held in the tropics - in Kuching (Malaysia) - brought together over 1000 international peatland scientists and industrial partners from across the world ("International Peat Congress with over 1000 participants!," 2016). The congress covered all aspects of peatland ecosystems and their management, with a strong focus on the environmental, societal and economic challenges associated with contemporary large-scale agricultural conversion of tropical peat. This article is protected by copyright...
September 27, 2016: Global Change Biology
C M Yim, M B Watkins, M J Wolf, C L Pang, K Hermansson, G Thornton
Polarons in metal oxides are important in processes such as catalysis, high temperature superconductivity, and dielectric breakdown in nanoscale electronics. Here, we study the behavior of electron small polarons associated with oxygen vacancies at rutile TiO_{2}(110), using a combination of low temperature scanning tunneling microscopy (STM), density functional theory, and classical molecular dynamics calculations. We find that the electrons are symmetrically distributed around isolated vacancies at 78 K, but as the temperature is reduced, their distributions become increasingly asymmetric, confirming their polaronic nature...
September 9, 2016: Physical Review Letters
Holly J Kramer, Adrienne M Stilp, Cathy C Laurie, Alex P Reiner, James Lash, Martha L Daviglus, Sylvia E Rosas, Ana C Ricardo, Bamidele O Tayo, Michael F Flessner, Kathleen F Kerr, Carmen Peralta, Ramon Durazo-Arvizu, Matt Conomos, Timothy Thornton, Jerome Rotter, Kent D Taylor, Jainwen Cai, John Eckfeldt, Han Chen, George Papanicolau, Nora Franceschini
African ancestry alleles may contribute to CKD among Hispanics/Latinos, but whether associations differ by Hispanic/Latino background remains unknown. We examined the association of CKD measures with African ancestry-specific APOL1 alleles that were directly genotyped and sickle cell trait (hemoglobin subunit β gene [HBB] variant) on the basis of imputation in 12,226 adult Hispanics/Latinos grouped according to Caribbean or Mainland background. We also performed an unbiased genome-wide association scan of urine albumin-to-creatinine ratios...
September 20, 2016: Journal of the American Society of Nephrology: JASN
Alastair D Hay, Niamh M Redmond, Sophie Turnbull, Hannah Christensen, Hannah Thornton, Paul Little, Matthew Thompson, Brendan Delaney, Andrew M Lovering, Peter Muir, John P Leeming, Barry Vipond, Beth Stuart, Tim J Peters, Peter S Blair
BACKGROUND: Antimicrobial resistance is a serious threat to public health, with most antibiotics prescribed in primary care. General practitioners (GPs) report defensive antibiotic prescribing to mitigate perceived risk of future hospital admission in children with respiratory tract infections. We developed a clinical rule aimed to reduce clinical uncertainty by stratifying risk of future hospital admission. METHODS: 8394 children aged between 3 months and 16 years presenting with acute cough (for ≤28 days) and respiratory tract infection were recruited to a prognostic cohort study from 247 general practitioner practices in England...
September 1, 2016: Lancet Respiratory Medicine
Anubha Mahajan, Aylin R Rodan, Thu H Le, Kyle J Gaulton, Jeffrey Haessler, Adrienne M Stilp, Yoichiro Kamatani, Gu Zhu, Tamar Sofer, Sanjana Puri, Jeffrey N Schellinger, Pei-Lun Chu, Sylvia Cechova, Natalie van Zuydam, Johan Arnlov, Michael F Flessner, Vilmantas Giedraitis, Andrew C Heath, Michiaki Kubo, Anders Larsson, Cecilia M Lindgren, Pamela A F Madden, Grant W Montgomery, George J Papanicolaou, Alex P Reiner, Johan Sundström, Timothy A Thornton, Lars Lind, Erik Ingelsson, Jianwen Cai, Nicholas G Martin, Charles Kooperberg, Koichi Matsuda, John B Whitfield, Yukinori Okada, Cathy C Laurie, Andrew P Morris, Nora Franceschini
We analyzed genome-wide association studies (GWASs), including data from 71,638 individuals from four ancestries, for estimated glomerular filtration rate (eGFR), a measure of kidney function used to define chronic kidney disease (CKD). We identified 20 loci attaining genome-wide-significant evidence of association (p < 5 × 10(-8)) with kidney function and highlighted that allelic effects on eGFR at lead SNPs are homogeneous across ancestries. We leveraged differences in the pattern of linkage disequilibrium between diverse populations to fine-map the 20 loci through construction of "credible sets" of variants driving eGFR association signals...
September 1, 2016: American Journal of Human Genetics
N K R Sehgal, C Sullivan, C Scallan, M Figueroa, J A Pencak, J Kirkland, K Scott, J D Thornton
INTRODUCTION: Previous studies suggest that large signature size is associated with narcissistic characteristics. By contrast, organ donation is an indicator of altruism. Because altruism and narcissism may be viewed as opposites, we sought to determine if smaller signature size is associated with willingness to be an organ donor. METHODS: Using a cross-sectional study design, we reviewed the health records of 571 randomly selected primary care patients at a large urban safety-net medical system to obtain their demographic and medical characteristics...
July 2016: Transplantation Proceedings
N K R Sehgal, C Sullivan, M Figueroa, J A Pencak, J D Thornton
BACKGROUND: Little is known about the stability of decisions that people make to be organ donors. We sought to determine the rate of stability of organ donor designations on driver's licenses. METHODS: With the use of a cross-sectional study design, we reviewed the health records of 2500 randomly selected primary-care patients at a large urban safety-net medical system to obtain their demographic and medical characteristics. We also examined the two most recent unique driver's licenses, state identification cards, or learner's permits that were scanned into electronic health records as part of the patient registration process...
July 2016: Transplantation Proceedings
Sebastián Marciano, Leila Haddad, Fernando Plazzotta, Ezequiel Mauro, Sergio Terraza, Sanjeev Arora, Karla Thornton, Beatriz Ríos, Carlos García Dans, Natalia Ratusnu, Liliana Calanni, José Allevato, María Ester Sirotinsky, Marcos Pedrosa, Adrián Gadano
OBJECTIVES: To implement the ECHO telementoring model for hepatitis C and to evaluate its outcomes in the health providers. METHODS: Following the ECHO model, an hepatitis C teleECHO clinic was established at the Hospital Italiano in Argentina. The teleECHO clinic provides support and training to physicians from Patagonia who treat patients with hepatitis C. In order to evaluate the teleECHO clinic outcomes, physicians completed a survey focused on skills and competence in hepatitis C before and after six months of participating in the project...
August 23, 2016: Journal of Medical Virology
Jiumeng Liu, Emma L D'Ambro, Ben H Lee, Felipe D Lopez-Hilfiker, Rahul A Zaveri, Jean C Rivera-Rios, Frank N Keutsch, Siddharth Iyer, Theo Kurten, Zhenfa Zhang, Avram Gold, Jason D Surratt, John E Shilling, Joel A Thornton
With a large global emission rate and high reactivity, isoprene has a profound effect upon atmospheric chemistry and composition. The atmospheric pathways by which isoprene converts to secondary organic aerosol (SOA) and how anthropogenic pollutants such as nitrogen oxides and sulfur affect this process are subjects of intense research because particles affect Earth's climate and local air quality. In the absence of both nitrogen oxides and reactive aqueous seed particles, we measure SOA mass yields from isoprene photochemical oxidation of up to 15%, which are factors of 2 or more higher than those typically used in coupled chemistry climate models...
September 20, 2016: Environmental Science & Technology
Samuel T Carrell, Ellie M Carrell, David Auerbach, Sanjay K Pandey, C Frank Bennett, Robert T Dirksen, Charles A Thornton
Myotonic dystrophy type 1 (DM1) is a genetic disorder in which dominant-active DM protein kinase (DMPK) transcripts accumulate in nuclear foci, leading to abnormal regulation of RNA processing. A leading approach to treat DM1 uses DMPK-targeting antisense oligonucleotides (ASOs) to reduce levels of toxic RNA. However, basal levels of DMPK protein are reduced by half in DM1 patients. This raises concern that intolerance for further DMPK loss may limit ASO therapy, especially since mice with Dmpk gene deletion reportedly show cardiac defects and skeletal myopathy...
August 13, 2016: Human Molecular Genetics
Rachel L J Thornton, Crystal M Glover, Crystal W Cené, Deborah C Glik, Jeffrey A Henderson, David R Williams
The opportunities for healthy choices in homes, neighborhoods, schools, and workplaces can have decisive impacts on health. We review scientific evidence from promising interventions focused on the social determinants of health and discuss how such interventions can improve population health and reduce health disparities. We found sufficient evidence of successful outcomes to support disparity-reducing policy interventions targeted at education and early childhood; urban planning and community development; housing; income enhancements and supplements; and employment...
August 1, 2016: Health Affairs
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