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https://www.readbyqxmd.com/read/29140232/country-wide-surveillance-of-molecular-markers-of-antimalarial-drug-resistance-in-senegal-by-use-of-positive-malaria-rapid-diagnostic-tests
#1
Magatte Ndiaye, Doudou Sow, Sidsel Nag, Khadime Sylla, Roger Clement Tine, Jean Louis Ndiaye, Aminata Collé Lo, Oumar Gaye, Babacar Faye, Michael Alifrangis
In Senegal, antimalarial drugs used in treatment and prevention of malaria are one of the main reasons for the current success in controlling malaria. However, the successful control of malaria is highly dependent on continued effectiveness of these drugs which may be compromised by the spread of drug resistance. Therefore, surveillance of drug resistance in the malaria parasites is essential. The objective of this pilot study was to test the feasibility of routinely sampled malaria rapid diagnostic tests (RDTs) at a national scale to assess the temporal changes in the molecular profiles of antimalarial drug resistance markers of Plasmodium falciparum parasites...
November 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29132317/development-of-amplicon-deep-sequencing-markers-and-data-analysis-pipeline-for-genotyping-multi-clonal-malaria-infections
#2
Anita Lerch, Cristian Koepfli, Natalie E Hofmann, Camilla Messerli, Stephen Wilcox, Johanna H Kattenberg, Inoni Betuela, Liam O'Connor, Ivo Mueller, Ingrid Felger
BACKGROUND: Amplicon deep sequencing permits sensitive detection of minority clones and improves discriminatory power for genotyping multi-clone Plasmodium falciparum infections. New amplicon sequencing and data analysis protocols are needed for genotyping in epidemiological studies and drug efficacy trials of P. falciparum. METHODS: Targeted sequencing of molecular marker csp and novel marker cpmp was conducted in duplicate on mixtures of parasite culture strains and 37 field samples...
November 13, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29131459/differential-contribution-of-interleukin-10-promoter-variants-in-malaria-and-schistosomiasis-mono-and-co-infections-among-nigerian-children
#3
Ayodele Adedoja, Nghiem Xuan Hoan, Hoang van Tong, Selorme Adukpo, Deborah B Tijani, Ajibola A Akanbi, Christian G Meyer, Olusola Ojurongbe, Thirumalaisamy P Velavan
OBJECTIVE: Interleukin-10 (IL-10) is an anti-inflammatory cytokine produced by Th1 cells and macrophages. The rationale of this study was to examine and validate possible contributions of IL-10 promoter polymorphisms in sub-Saharan Africa in children infected with either Plasmodium falciparum or Schistosoma haematobium and in children co-infected with both parasites. MATERIALS AND METHODS: 309 Nigerian children aged 4 to 15 years were recruited. The study group consisted of individuals infected either with P...
November 13, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29127677/current-standards-of-care-and-long-term-outcomes-for-thalassemia-and-sickle-cell-disease
#4
Satheesh Chonat, Charles T Quinn
Thalassemia and sickle cell disease (SCD) are disorders of hemoglobin that affect millions of people worldwide. The carrier states for these diseases arose as common, balanced polymorphisms during human history because they afforded protection against severe forms of malaria. These complex, multisystem diseases are reviewed here with a focus on current standards of clinical management and recent research findings. The importance of a comprehensive, multidisciplinary and lifelong system of care is also emphasized...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29114153/genetic-polymorphism-of-plasmodium-vivax-duffy-binding-protein-in-malarious-areas-in-southeastern-of-iran
#5
Mehdi Nateghpour, Afsaneh Motevalli Haghi, Bahare Naderi, Zargham Sepehrizadeh
Plasmodium vivax parasite causes the largest number of malaria infection in some malarious areas of the world including Iran. Considering transfer and genetic dynamics of the parasite population in a specific area can help us to predict the spread of the infection either emergence of new cases or drug resistance in the context of elimination program in the malarious areas. Study on the genetic diversity of common alleles in a given geographical area, for vaccine and immune level studies can be important. The purpose of this study was to know the status of P...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29103262/genetic-diversity-and-natural-selection-in-42-kda-region-of-plasmodium-vivax-merozoite-surface-protein-1-from-china-myanmar-endemic-border
#6
Xia Zhou, Ernest Tambo, Jing Su, Qiang Fang, Wei Ruan, Jun-Hu Chen, Ming-Bo Yin, Xiao-Nong Zhou
Plasmodium vivax merozoite surface protein-1 (PvMSP1) gene codes for a major malaria vaccine candidate antigen. However, its polymorphic nature represents an obstacle to the design of a protective vaccine. In this study, we analyzed the genetic polymorphism and natural selection of the C-terminal 42 kDa fragment within PvMSP1 gene (Pv MSP142) from 77 P. vivax isolates, collected from imported cases of China-Myanmar border (CMB) areas in Yunnan province and the inland cases from Anhui, Yunnan, and Zhejiang province in China during 2009-2012...
October 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29097639/anopheline-mosquitoes-behaviour-and-entomological-monitoring-in-southwestern-ethiopia
#7
Kidane Lelisa, Abebe Asale, Behailu Taye, Daniel Emana, Delenasaw Yewhalaw
BACKGROUND & OBJECTIVES: Despite a tremendous expansion in the financing and coverage of malaria control programmes, the disease continues to be a global health threat. This study was conducted to assess the entomological parameters of anopheline mosquitoes, viz. species composition, abundance, longevity, behaviour and infectivity rates in Kersa district, Jimma zone, southwestern Ethiopia. METHODS: Mosquito collection was carried out from each selected household in each of the nine selected study villages of Kersa district, using CDC light-traps and pyrethrum spray catches (PSCs) for seven months (June to December 2014)...
July 2017: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/29077712/quantifying-connectivity-between-local-plasmodium-falciparum-malaria-parasite-populations-using-identity-by-descent
#8
Aimee R Taylor, Stephen F Schaffner, Gustavo C Cerqueira, Standwell C Nkhoma, Timothy J C Anderson, Kanlaya Sriprawat, Aung Pyae Phyo, François Nosten, Daniel E Neafsey, Caroline O Buckee
With the rapidly increasing abundance and accessibility of genomic data, there is a growing interest in using population genetic approaches to characterize fine-scale dispersal of organisms, providing insight into biological processes across a broad range of fields including ecology, evolution and epidemiology. For sexually recombining haploid organisms such as the human malaria parasite P. falciparum, however, there have been no systematic assessments of the type of data and methods required to resolve fine scale connectivity...
October 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29065113/identification-of-immune-signatures-predictive-of-clinical-protection-from-malaria
#9
John Joseph Valletta, Mario Recker
Antibodies are thought to play an essential role in naturally acquired immunity to malaria. Prospective cohort studies have frequently shown how continuous exposure to the malaria parasite Plasmodium falciparum cause an accumulation of specific responses against various antigens that correlate with a decreased risk of clinical malaria episodes. However, small effect sizes and the often polymorphic nature of immunogenic parasite proteins make the robust identification of the true targets of protective immunity ambiguous...
October 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29063888/epidemiology-of-malaria-and-msp-2-gene-based-genetic-diversity-of-plasmodium-falciparum-from-patients-attending-community-health-centre-jiribam-manipur
#10
Indu Sharma, Appu Saikia, Paromita Chakraborty
Two millilitres of peripheral blood was collected from 323 patients of different age groups and rapid diagnosis (RDT test) was performed. Parasite genomic DNA was extracted from whole blood and MSP-2 gene-based diversity and polymorphism was determined followed by restriction fragment length polymorphism analysis using Taq 1 and Vsp 1 digestion of each polymerase chain reaction product to analyse MSP-2 genotypes. Twenty-six sequences of P. falciparum MSP-2 gene were retrieved from the current GenBank database to represent strains from various geographical locations and were analysed for the Taq 1 and Vsp 1 enzyme restriction sites using in silico restriction digestion in Sequence Manipulation Suite, Version 2...
July 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29062081/an-engineered-vaccine-of-the-plasmodium-vivax-duffy-binding-protein-enhances-induction-of-broadly-neutralizing-antibodies
#11
Francis B Ntumngia, Camilla V Pires, Samantha J Barnes, Miriam T George, Richard Thomson-Luque, Flora S Kano, Jessica R S Alves, Darya Urusova, Dhelio B Pereira, Niraj H Tolia, Christopher L King, Luzia H Carvalho, John H Adams
Plasmodium vivax invasion into human reticulocytes is a complex process. The Duffy binding protein (DBP) dimerization with its cognate receptor is vital for junction formation in the invasion process. Due to its functional importance, DBP is considered a prime vaccine candidate, but variation in B-cell epitopes at the dimer interface of DBP leads to induction of strain-limited immunity. We believe that the polymorphic residues tend to divert immune responses away from functionally conserved epitopes important for receptor binding or DBP dimerization...
October 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042203/association-of-antibodies-to-plasmodium-falciparum-merozoite-surface-protein-4-with-protection-against-clinical-malaria
#12
Ronald Perraut, Marie-Louise Varela, Charlotte Joos, Babacar Diouf, Cheikh Sokhna, Babacar Mbengue, Adama Tall, Cheikh Loucoubar, Aissatou Touré, Odile Mercereau-Puijalon
Identification of parasite antigens targeted by immune effector mechanisms that confer protection against malaria is important for the design of a multi-component malaria vaccine. Here, the association of antibodies reacting with the Plasmodium falciparum merozoite surface protein-4 (MSP4) with protection against clinical malaria was investigated in a Senegalese community living in an area of moderate, seasonal malaria transmission. Blood samples were collected at the end of an 8-month long dry season without any recorded parasite transmission from 206 residents enrolled in a prospective follow-up study...
October 14, 2017: Vaccine
https://www.readbyqxmd.com/read/29034365/ethnicity-sex-and-age-are-determinants-of-red-blood-cell-storage-and-stress-hemolysis-results-of-the-reds-iii-rbc-omics-study
#13
Tamir Kanias, Marion C Lanteri, Grier P Page, Yuelong Guo, Stacy M Endres, Mars Stone, Sheila Keating, Alan E Mast, Ritchard G Cable, Darrell J Triulzi, Joseph E Kiss, Edward L Murphy, Steve Kleinman, Michael P Busch, Mark T Gladwin
Genetic polymorphisms in blood donors may contribute to donor-specific differences in the survival of red blood cells (RBCs) during cold storage and after transfusion. Genetic variability is anticipated to be high in donors with racial admixture from malaria endemic regions such as Africa and Asia. The purpose of this study was to test the hypothesis that donor genetic background, reflected by sex and self-reported ethnicity, significantly modulates RBC phenotypes in storage. High throughput hemolysis assays were developed and used to evaluate stored RBC samples from 11 115 African American, Asian, white, and Hispanic blood donors from 4 geographically diverse regions in the United States...
June 27, 2017: Blood Advances
https://www.readbyqxmd.com/read/29033373/evaluating-the-causal-link-between-malaria-infection-and-endemic-burkitt-lymphoma-in-northern-uganda-a-mendelian-randomization-study
#14
Ismail D Legason, Ruth M Pfeiffer, Krizia-Ivana Udquim, Andrew W Bergen, Mateus H Gouveia, Samuel Kirimunda, Isaac Otim, Eric Karlins, Patrick Kerchan, Hadijah Nabalende, Ariunaa Bayanjargal, Benjamin Emmanuel, Paul Kagwa, Ambrose O Talisuna, Kishor Bhatia, Meredith Yeager, Robert J Biggar, Leona W Ayers, Steven J Reynolds, James J Goedert, Martin D Ogwang, Joseph F Fraumeni, Ludmila Prokunina-Olsson, Sam M Mbulaiteye
BACKGROUND: Plasmodium falciparum (Pf) malaria infection is suspected to cause endemic Burkitt Lymphoma (eBL), but the evidence remains unsettled. An inverse relationship between sickle cell trait (SCT) and eBL, which supports that between malaria and eBL, has been reported before, but in small studies with low power. We investigated this hypothesis in children in a population-based study in northern Uganda using Mendelian Randomization. METHODS: Malaria-related polymorphisms (SCT, IL10, IL1A, CD36, SEMA3C, and IFNAR1) were genotyped in 202 eBL cases and 624 controls enrolled during 2010-2015...
October 3, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29016333/distribution-of-mutations-associated-with-antifolate-and-chloroquine-resistance-among-imported-plasmodium-vivax-in-the-state-of-qatar
#15
Devendra Bansal, Anushree Acharya, Praveen K Bharti, Mohamed H Abdelraheem, Ashraf Elmalik, Salem Abosalah, Fahmi Y Khan, Mohamed ElKhalifa, Hargobinder Kaur, Pradyumna K Mohapatra, Rakesh Sehgal, Mohammed A Idris, Jagadish Mahanta, Neeru Singh, Hamza A Babiker, Ali A Sultan
Plasmodium vivax is the most prevalent parasite worldwide, escalating by spread of drug resistance. Currently, in Qatar, chloroquine (CQ) plus primaquine are recommended for the treatment of P. vivax malaria. The present study examined the prevalence of mutations in dihydrofolate reductase (dhfr), dihydropteroate synthase (dhps) genes and CQ resistance transporter (crt-o) genes, associated with sulphadoxine-pyrimethamine (SP) and chloroquine resistance, among imported P. vivax cases in Qatar. Blood samples were collected from patients positive for P...
October 2, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29016309/comparative-prevalence-of-plasmodium-falciparum-resistance-associated-genetic-polymorphisms-in-parasites-infecting-humans-and-mosquitoes-in-uganda
#16
Melissa D Conrad, Daniel Mota, Alex Musiime, Maxwell Kilama, John Rek, Moses Kamya, Grant Dorsey, Philip J Rosenthal
Controlling malaria in high transmission areas, such as much of sub-Saharan Africa, will require concerted efforts to slow the spread of drug resistance and to impede malaria transmission. Understanding the fitness costs associated with the development of drug resistance, particularly within the context of transmission, can help guide policy decisions to accomplish these goals, as fitness constraints might lead to decreased transmission of drug-resistant strains. To determine if Plasmodium falciparum resistance-mediating polymorphisms impact on development at different parasite stages, we compared the genotypes of parasites infecting humans and mosquitoes from households in Uganda...
September 25, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28991911/associations-between-an-igg3-polymorphism-in-the-binding-domain-for-fcrn-transplacental-transfer-of-malaria-specific-igg3-and-protection-against-plasmodium-falciparum-malaria-during-infancy-a-birth-cohort-study-in-benin
#17
Celia Dechavanne, Sebastien Dechavanne, Ibrahim Sadissou, Adjimon Gatien Lokossou, Fernanda Alvarado, Magalie Dambrun, Kabirou Moutairou, David Courtin, Gregory Nuel, Andre Garcia, Florence Migot-Nabias, Christopher L King
BACKGROUND: Transplacental transfer of maternal immunoglobulin G (IgG) to the fetus helps to protect against malaria and other infections in infancy. Recent studies have emphasized the important role of malaria-specific IgG3 in malaria immunity, and its transfer may reduce the risk of malaria in infancy. Human IgGs are actively transferred across the placenta by binding the neonatal Fc receptor (FcRn) expressed within the endosomes of the syncytiotrophoblastic membrane. Histidine at position 435 (H435) provides for optimal Fc-IgG binding...
October 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28975866/slco1a2-slco1b1-and-slco2b1-polymorphisms-influences-chloroquine-and-primaquine-treatment-in-plasmodium-vivax-malaria
#18
Vinicius A Sortica, Juliana D Lindenau, Maristela G Cunha, Maria Deise O Ohnishi, Ana Maria R Ventura, Ândrea Kc Ribeiro-Dos-Santos, Sidney Eb Santos, Luciano Sp Guimarães, Mara H Hutz
AIM: The association of transporters gene polymorphisms with chloroquine/primaquine malaria treatment response was investigated in a Brazilian population. PATIENTS & METHODS: Totally, 164 Plasmodium vivax malaria infected patients were included. Generalized estimating equations were performed to determine gene influences on parasitemia and/or gametocytemia clearance over treatment time. RESULTS: Significant interaction between SLCO2B1 genotypes and treatment over time for parasitemia clearance rate on day 2 were observed (p FDR = 0...
October 4, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28970738/genetic-diversity-of-cd14-promoter-gene-polymorphism-rs2569190-is-associated-with-regulation-of-malaria-parasitemia-and-susceptibility-to-plasmodium-falciparum-infection
#19
Olusola Ojurongbe, Roland I Funwei, Tara J Snyder, Najihah Aziz, Yi Li, Catherine O Falade, Bolaji N Thomas
CD14 is a multifunctional receptor expressed on many cell types and has been shown to mediate immune response resulting in the activation of an inflammatory cascade, with polymorphism of its promoter (rs2569190) found to be associated with susceptibility to several diseases. In malaria infection, the CD14 gene demonstrated a pathogenic profile in regulating experimental cerebral malaria, with reports of elevated levels of soluble CD14 in serum of patients but no definitive conclusion. We present a detailed analysis of genetic diversity of CD14 promoter gene (snp -159 C/T; rs2519190) polymorphism between a malaria-infected group and uninfected controls and its association with clinical parameters of disease...
2017: Infectious Diseases
https://www.readbyqxmd.com/read/28968782/impact-of-intermittent-preventive-treatment-during-pregnancy-on-plasmodium-falciparum-drug-resistance-mediating-polymorphisms-in-uganda
#20
Melissa D Conrad, Daniel Mota, Marissa Foster, Stephen Tukwasibwe, Jennifer Legac, Patrick Tumwebaze, Meghan Whalen, Abel Kakuru, Patience Nayebare, Erika Wallender, Diane V Havlir, Prasanna Jagannathan, Liusheng Huang, Francesca Aweeka, Moses R Kamya, Grant Dorsey, Philip J Rosenthal
Background: In a recent trial of intermittent preventive treatment in pregnancy (IPTp) in Uganda, dihydroartemisinin-piperaquine (DP) was superior to sulfadoxine-pyrimethamine (SP) in preventing maternal and placental malaria. Methods: We compared genotypes using sequencing, fluorescent microsphere, and qPCR assays at loci associated with drug resistance in Plasmodium falciparum isolated from subjects receiving DP or SP. Results: Considering aminoquinoline resistance, DP was associated with increased prevalences of mutations at pfmdr1 N86Y, pfmdr1 Y184F, and pfcrt K76T compared to SP (64...
August 22, 2017: Journal of Infectious Diseases
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