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https://www.readbyqxmd.com/read/27843927/alopecia-areata-as-a-manifestation-of-systemic-lymphoma-report-of-two-cases
#1
Yuval Ramot, Alexander Gural, Abraham Zlotogorski
Alopecia areata is a common autoimmune disorder leading to hair loss. It usually affects individuals under the age of 40, and first appearance in older subjects is considered uncommon. Here, we report 2 cases of rapidly progressing alopecia areata, which appeared for the first time in adults. Patient 1 had alopecia universalis, which preceded the identification of hepatosplenic T-cell lymphoma, a rare form of lymphoma. Patient 2 suffered from the ophiasis type of alopecia areata, presenting for the first time following chemotherapy for non-Hodgkin B-cell lymphoma...
September 2016: Skin Appendage Disorders
https://www.readbyqxmd.com/read/27730032/serum-vitamin-d-in-patients-with-alopecia-areata
#2
Ola Ahmed Bakry, Shawky M El Farargy, Maathir K El Shafiee, Amira Soliman
BACKGROUND: Alopecia areata (AA) is a common, recurrent, autoimmune hair disorder. It has been found that vitamin D deficiency is associated with many autoimmune diseases. AIMS: The current study aimed to estimate serum levels of 25-hydroxy vitamin D in patients with AA. MATERIALS AND METHODS: This case-control study included 60 patients with AA and 60 age, gender, skin phototype, and body mass index-matched healthy subjects as a control group...
September 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27699252/safety-and-efficacy-of-the-jak-inhibitor-tofacitinib-citrate-in-patients-with-alopecia-areata
#3
Milène Kennedy Crispin, Justin M Ko, Brittany G Craiglow, Shufeng Li, Gautam Shankar, Jennifer R Urban, James C Chen, Jane E Cerise, Ali Jabbari, Mårten C G Winge, M Peter Marinkovich, Angela M Christiano, Anthony E Oro, Brett A King
BACKGROUND: Alopecia areata (AA) is an autoimmune disease characterized by hair loss mediated by CD8(+) T cells. There are no reliably effective therapies for AA. Based on recent developments in the understanding of the pathomechanism of AA, JAK inhibitors appear to be a therapeutic option; however, their efficacy for the treatment of AA has not been systematically examined. METHODS: This was a 2-center, open-label, single-arm trial using the pan-JAK inhibitor, tofacitinib citrate, for AA with >50% scalp hair loss, alopecia totalis (AT), and alopecia universalis (AU)...
September 22, 2016: JCI Insight
https://www.readbyqxmd.com/read/27061214/ocular-findings-in-patients-with-alopecia-areata
#4
Oktay Esmer, Remzi Karadag, Ozgur Cakici, Serap Gunes Bilgili, Yuhanize Tas Demircan, Huseyin Bayramlar, Ayse S Karadag
OBJECTIVES: This study investigated ocular findings in patients with alopecia. METHODS: A total of 42 patients with alopecia (31 male, 11 female; 84 eyes) and 45 healthy individuals (28 male, 17 female; 90 eyes) were enrolled in the study. Of the patients with alopecia, 34 had alopecia areata, seven had alopecia universalis, and one had ophiasis alopecia. Seven patients had eyebrow involvement and seven had eyelash involvement. Autorefractometry, keratometry, visual acuity, central corneal thickness and intraocular pressure (IOP) measurements, bilateral anterior and posterior segment examinations, Schirmer's tests, and visual field examinations were performed in both groups...
July 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/27051761/successful-treatment-of-corticosteroid-resistant-ophiasis-type-alopecia-areata-aa-with-platelet-rich-plasma-prp
#5
Jeff Donovan
No abstract text is available yet for this article.
September 2015: JAAD Case Reports
https://www.readbyqxmd.com/read/26371097/alopecia-areata-part-1-pathogenesis-diagnosis-and-prognosis
#6
REVIEW
Frank Spano, Jeff C Donovan
OBJECTIVE: To provide family physicians with a background understanding of the epidemiology, pathogenesis, histology, and clinical approach to the diagnosis of alopecia areata (AA). SOURCES OF INFORMATION: PubMed was searched for relevant articles regarding the pathogenesis, diagnosis, and prognosis of AA. MAIN MESSAGE: Alopecia areata is a form of autoimmune hair loss with a lifetime prevalence of approximately 2%. A personal or family history of concomitant autoimmune disorders, such as vitiligo or thyroid disease, might be noted in a small subset of patients...
September 2015: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/26179196/combined-oral-pulse-and-topical-corticosteroid-therapy-for-severe-alopecia-areata-in-children-a-long-term-follow-up-study
#7
Jovan Lalosevic, Mirjana Gajic-Veljic, Branka Bonaci-Nikolic, Milos Nikolic
There are no widely accepted therapy protocols for severe alopecia areata (AA). We treated 65 children/adolescents with AA affecting >30% of scalp. Fourty-three percent of patients had AA plurifocalis (AAP). Fifty-seven percent had AA subtotalis (AAS), AAP+ophiasis (AAP+OPH), and alopecia totalis/universalis (AT/AU). Long-term follow-up (median 96 months) data were available for 69% of patients. Oral dexamethasone (prednisolone 5 mg/kg equivalent) was given once in 4 weeks. Patients received 6, 9, or 12 pulses...
September 2015: Dermatologic Therapy
https://www.readbyqxmd.com/read/25556409/an-observational-study-of-alopecia-areata-in-sri-lankan-adult-patients
#8
R R Ranawaka
OBJECTIVES: The objectives were to assess the demographical pattern, clinical presentation and therapeutic response in a cohort of patients with alopecia areata (AA) in Sri Lanka. METHODS: Hospital-based observational study of 290 adults aged 18 years or above. RESULTS: Alopecia areata was commoner in men (M:F=1.3:1). Age of onset was between 20-35 years (median 31 years) in 61%. Those with juvenile-onset AA (≤ 17 years, n=5) showed severe disease with many relapses and resistance to therapy...
December 2014: Ceylon Medical Journal
https://www.readbyqxmd.com/read/24383154/alopecia-areata-more-than-skin-deep
#9
REVIEW
Kirsty J MacLean, Michael J Tidman
Alopecia areata is a chronic inflammatory non-scarring condition affecting the hair follicle that leads to hair loss ranging from small well defined patches to complete loss of all body hair. In about 80% of affected individuals there is spontaneous regrowth within a year. It can present at any age, although 60% of patients develop their first episode of hair loss before the age of 20. There is a family history of alopecia areata in 20% of cases indicative of a genetic basis. A positive family history is prognostic of troublesome alopecia areata, as are onset in childhood, ophiasis (involvement of the scalp hair margins), nail changes and concurrent atopic disease...
September 2013: Practitioner
https://www.readbyqxmd.com/read/24371395/early-intervention-with-high-dose-steroid-pulse-therapy-prolongs-disease-free-interval-of-severe-alopecia-areata-a-retrospective-study
#10
Chao-Chun Yang, Chun-Te Lee, Chao-Kai Hsu, Yi-Pei Lee, Tak-Wah Wong, Sheau-Chiou Chao, Julia Yu-Yun Lee, Hamm-Ming Sheu, Wenchieh Chen
BACKGROUND: Spontaneous recovery of severe alopecia areata is rare and the condition is difficult to treat. OBJECTIVE: The aim of this study is to investigate and compare the effects and safety of steroid pulse therapy between oral and intravenous administrations between 1999 and 2010 at the Department of Dermatology, National Cheng Kung University Hospital. METHODS: Data were retrospectively retrieved. A satisfactory response was defined as more than 75% hair regrowth in the balding area...
November 2013: Annals of Dermatology
https://www.readbyqxmd.com/read/24326541/overview-of-alopecia-areata
#11
REVIEW
Maria K Hordinsky
Alopecia areata is a complex genetic, immune-mediated disease that targets anagen hair follicles. The disease affects children and adults and is characterized by round or oval patches of hair loss, loss of all scalp hair (alopecia totalis), body hair (alopecia universalis), or ophiasis pattern hair loss. Patients may also present with patchy loss in multiple hair-bearing areas. Commonly associated diseases include asthma, allergic rhinitis, atopic dermatitis, thyroid disease, and automimmune diseases, such as thyroiditis and vitiligo...
December 2013: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/24008264/pulse-corticosteroid-therapy-for-alopecia-areata-in-children-a-retrospective-study
#12
Rivka Friedland, Rotem Tal, Moshe Lapidoth, Alex Zvulunov, Dan Ben Amitai
BACKGROUND/OBJECTIVE: Alopecia areata may occur at any age, though usually before the age of 20 years. Treatment often consists of systemic steroids administered as high-dose bolus infusions. This study sought to investigate the effectiveness and side effects of intravenous high-dose pulse corticosteroids in children with alopecia areata and to identify prognostic factors for successful treatment. METHODS: Patients treated with pulse corticosteroids for alopecia areata in 2001-2008 at the day care unit of a tertiary pediatric medical center were identified by computerized file search and clinical treatment and outcome data were collected...
2013: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/23464363/clinical-effects-of-non-ablative-and-ablative-fractional-lasers-on-various-hair-disorders-a-case-series-of-17-patients
#13
Suhyun Cho, Min Ju Choi, Zhenlong Zheng, Boncheol Goo, Do-Young Kim, Sung Bin Cho
BACKGROUND AND OBJECTIVES: Both ablative and non-ablative fractional lasers have been applied to various uncommon hair disorders. The purpose of this study was to demonstrate the clinical effects of fractional laser therapy on the course of primary follicular and perifollicular pathologies and subsequent hair regrowth. MATERIALS AND METHODS: A retrospective review of 17 patients with uncommon hair disorders - including ophiasis, autosomal recessive woolly hair/hypotrichosis, various secondary cicatricial alopecias, pubic hypotrichosis, frontal fibrosing alopecia, and perifolliculitis abscedens et suffodiens - was conducted...
April 2013: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/23364150/examining-the-relationship-between-alopecia-areata-androgenetic-alopecia-and-emotional-intelligence
#14
Assaf Monselise, Reuven Bar-On, Lisa Chan, Naama Leibushor, Kevin McElwee, Jerry Shapiro
BACKGROUND: Emotional stress has been associated with the development of alopecia areata (AA) and androgenetic alopecia (AGA). Emotional intelligence (EI), a component of general intelligence, is thought to govern the recognition, expression, and control of stress and other emotions. People with low EI are unable to adequately control stress in everyday life. OBJECTIVE: To investigate EI differences between AA and AGA patients and a control population. METHODS: Thirty-five AGA patients and 42 AA patients, with patchy (n  =  28), ophiasis (n  =  5), totalis (n  =  5), and universalis (n  =  4) distribution of hair loss, completed a 133-item Emotional Quotient-Inventory (EQ-I ) psychometric assessment...
January 2013: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/22768432/alopecia-in-an-ophiasis-pattern-traction-alopecia-versus-alopecia-areata
#15
Candrice R Heath, Susan C Taylor
We present a case series of 3 black women who presented with alopecia along the anterior and posterior hairline on physical examination. The initial clinical suspicion was traction alopecia from tension placed on the hair and traumatic removal of hairweaves. Two cases were supported histologically as traction alopecia, while the remaining case was alopecia areata in an ophiasis pattern. Interestingly, the case of alopecia areata was associated with the mildly traumatic removal of a weave. Traction alopecia may present in an ophiasis pattern from hair care practices...
May 2012: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/22426909/efficacy-and-safety-of-oral-mega-pulse-methylprednisolone-for-severe-therapy-resistant-alopecia-areata
#16
Ghada A Bin Saif, Marwan M Al-Khawajah, Hend M Al-Otaibi, Abdulaziz S Al-Roujayee, Abdullateef A Alzolibani, Hatem A Kalantan, Omar A Al-Sheikh, Maha M Arafah
OBJECTIVE: To use intensive regimen of pulse steroid in the severe forms of Alopecia areata. METHODS: This prospective randomized study was conducted at King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia between 2003 to 2009. Patients with Alopecia universalis, Alopecia totalis, or Alopecia ophiasis were assigned to one of the 3 treatment groups: Group A received oral mega pulse methylprednisolone (MP) for 3 consecutive days once every 2 weeks for 24 weeks; Group B received 2 consecutive daily pulses every 3 weeks; and Group C received 3 consecutive daily pulses every 3 weeks...
March 2012: Saudi Medical Journal
https://www.readbyqxmd.com/read/22223966/extensive-alopecia-areata-not-necessarily-recalcitrant-to-therapy
#17
Deepal Deshpande, Rachita Dhurat, Punit Saraogi, Sunil Mishra, Chitra Nayak
BACKGROUND: Extensive alopecia areata includes alopecia universalis, alopecia totalis, ophiasis and patients having more than 50% scalp involvement. Alopecia universalis (AU) and totalis (AT) are considered to be resistant to single modalities of treatment. Our study highlights the efficacy and safety of combination therapy in extensive alopecia areata. AIM: To evaluate the efficacy and safety of a combination treatment with oral bethametasone mini-pulse, topical minoxidil and short contact anthralin in long-standing, treatment-resistant, extensive alopecia areata...
July 2011: International Journal of Trichology
https://www.readbyqxmd.com/read/21965849/utility-of-dermoscopy-in-alopecia-areata
#18
Mandar Mane, Amiya Kumar Nath, Devinder Mohan Thappa
BACKGROUND: Alopecia areata (AA) shows several well-defined dermoscopic features which may help in confirming diagnosis in AA. AIMS: We carried out a study to examine the dermoscopic features of AA and develop a protocol for diagnosis of AA by dermoscopy. MATERIALS AND METHODS: Dermoscopy was performed in 66 patients with AA. Hanse HVS-500NP dermoscope (magnification of ×32 and ×140) was used. RESULTS: The mean age of the patients (46 males and 20 females) was 26...
July 2011: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/21692870/is-atopy-and-autoimmunity-more-prevalent-in-patients-with-alopecia-areata-a-comparative-study
#19
G Serarslan, N Savaş, J Z Yenin
OBJECTIVE:   We aimed to determine whether there was a difference between adult and paediatric alopecia areata patients with respect to the severity and pattern of the disease, nail changes and personal and family history of autoimmune diseases and also in comparison with controls. METHODS:   Two groups were included: patients with onset of alopecia before the age of ≤18 years and >18 years. The total number of the patients were 124. The control group was comprised of 114 age- and gender-matched patients...
June 2012: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/21689244/alopecia-areata-clinical-presentation-diagnosis-and-unusual-cases
#20
Andreas M Finner
Alopecia areata (AA) is a nonscarring hair loss disorder with a 2% lifetime risk. Most patients are below 30 years old. Clinical types include patchy AA, AA reticularis, diffuse AA, AA ophiasis, AA sisiapho, and perinevoid AA. Besides scalp and body hair, the eyebrows, eyelashes, and nails can be affected. The disorder may be circumscribed, total (scalp hair loss), and universal (loss of all hairs). Atopy, autoimmune thyroid disease, and vitiligo are more commonly associated. The course of the disease is unpredictable...
May 2011: Dermatologic Therapy
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