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alopecia universalis

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https://www.readbyqxmd.com/read/28973128/screening-guidelines-for-thyroid-function-in-children-with-alopecia-areata
#1
Deepa Patel, Ping Li, Andrew J Bauer, Leslie Castelo-Soccio
Importance: The incidence of thyroid disease in children with alopecia areata (AA) has been widely studied with no consensus on whether a true association with AA exists. In addition, screening practices for thyroid dysfunction in children with AA vary widely among clinicians. Objective: To reduce health care costs, eliminate unnecessary testing, and standardize clinical practices, we sought to to characterize thyroid function in children with AA to establish guidelines for screening...
September 27, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28940615/satoyoshi-syndrome-a-case-report-from-india
#2
Venkatraman Mani, Renu George
Satoyoshi syndrome was first reported in Japan in 1967. It is a rare multisystem disorder of presumed autoimmune etiology that is characterized by alopecia, intermittent painful muscle spasms, diarrhea, and antinuclear antibody positivity. We report an 11-year-old girl with Satoyoshi syndrome who presented to the dermatology department for treatment of alopecia universalis. We present this case to emphasize the importance of recognizing Satoyoshi syndrome, which could go unnoticed if not suspected.
September 22, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28932754/hair-growth-in-two-alopecia-patients-after-fecal-microbiota-transplant
#3
Dionne Rebello, Elaina Wang, Eugene Yen, Peter A Lio, Colleen R Kelly
Clostridium difficile infections can be life-threatening but are increasingly being treated successfully with fecal microbiota transplantation (FMT). We report two patients with alopecia universalis who developed subsequent hair regrowth after FMT for treatment of recurrent C. difficile infections. Gut microbiota may have immunomodulatory effects in autoimmune conditions such as alopecia areata, and further study may elucidate disease mechanisms and lead to alternative treatment options for these patients for whom treatment options are currently limited...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28879192/unsuccessful-treatment-of-alopecia-areata-with-simvastatin-ezetimibe-experience-in-12-patients
#4
Mabe Freitas Gouveia, Ralph M Trüeb
BACKGROUND/AIMS: Alopecia areata is a common immune-mediated hair condition with limited treatment options and success rates. There is evidence that statins, which are used for reducing atherogenesis and cardiovascular disease, have immunomodulatory activities and therefore may also be used for treatment of selected dermatologic conditions, including alopecia areata. Among treatments evaluated for alopecia areata, oral simvastatin/ezetimibe therapy is currently under the scrutiny of expert opinion...
August 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/28839389/rare-presentation-of-alopecia-universalis-congenita-and-twenty-nail-dystrophy-in-siblings
#5
Debdeep Mitra, Reetu Agarwal, Ajay Chopra, Renu Kandpal
Congenital alopecia universalis is one of the rarest anomaly which involves skin and appendages. The inheritance pattern can be autosomal recessive, X-linked recessive, or autosomal dominant. However, the most common is autosomal recessive form and it is the most severe phenotype. Twenty-nail dystrophy refers to the condition in which all the twenty nails are affected in the form of excessive ridging and nail plate roughness leading to unsightly lustureless nails. We report a rare case of two siblings with alopecia universalis congenita with twenty-nail dystrophy...
April 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28827491/pyridostigmine-induced-bradycardia-in-patient-with-musk-ab-positive-myasthenia-gravis-and-alopecia-universalis
#6
Ferdos Nazari, Siamak Abdi
No abstract text is available yet for this article.
September 2017: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/28755063/brazilian-experience-of-the-treatment-of-alopecia-universalis-with-the-novel-antirheumatic-therapy-tofacitinib-a-case-series
#7
Morton Scheinberg, Regina Adalva de Lucena Couto Océa, Boris Afonso Cruz, Sineida Berbert Ferreira
INTRODUCTION: Alopecia universalis is an autoimmune disorder for which there is no known effective therapy. Tofacitinib-a novel antirheumatic therapy for rheumatoid arthritis-has been shown in some reports to induce sustained hair growth in patients with alopecia universalis. CASE SERIES: Here, we review the experiences of four different rheumatologists across the country regarding four Brazilian patients with alopecia universalis who were treated with tofacitinib ...
July 28, 2017: Rheumatology and Therapy
https://www.readbyqxmd.com/read/28705291/lichenoid-dermatitis-in-an-adult-with-immune-dysregulation-polyendocrinopathy-enteropathy-x-linked-ipex-syndrome
#8
Young M Choi, Yen T Wang, Bob Geng, Maria Garcia-Lloret, Chandra N Smart
A 23-year-old man presented to our practice with erythroderma and an unusual retiform eruption, along with alopecia universalis and nail dystrophy. He had had no skin findings at birth, but since early infancy had had localized eczematous eruptions of his skin. At 10 years of age, he had developed a generalized eczematous flare requiring hospitalization, and another generalized episode occurred in October 2010. He was prescribed prednisone 60 mg daily, which initially provided an improvement, but tapering of the corticosteroid resulted in another generalized flare...
2017: Skinmed
https://www.readbyqxmd.com/read/28704810/long-term-prognosis-of-alopecia-totalis-and-alopecia-universalis-a-longitudinal-study-with-more-than-10-years-of-follow-up-better-than-reported
#9
Yong Hyun Jang, Nam-Soo Hong, Sun Young Moon, Dong Hyuk Eun, Won Kee Lee, Seong Geun Chi, Jun Young Kim, Weon Ju Lee, Seok-Jong Lee, Do Won Kim
BACKGROUND: In alopecia totalis (AT) and alopecia universalis (AU), the chance of full hair regrowth is known to be less than 10%. However, this information is based on a few older studies conducted in the 1950s and 1960s. OBJECTIVE: We investigated the current long-term prognosis of individuals with AT/AU. METHODS: A retrospective chart review was performed in patients with AT/AU between 1994 and 2005. Outcome data were collected by reviewing outpatient clinical files or by phone interviews...
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28635319/a-case-of-topical-ruxolitinib-treatment-failure-in-alopecia-areata
#10
Maya Deeb, Renée A Beach
Alopecia areata (AA) is an autoimmune-mediated, nonscarring form of hair loss. Despite its prevalence, current management options are limited, especially when the disease has progressed to alopecia totalis (AT) or alopecia universalis (AU). Recent evidence that janus kinase (JAK) signaling contributes to AA pathogenesis prompted the investigation of JAK inhibitors such as tofacitinib and ruxolitinib as possible oral treatments. However, the potential for significant adverse effects with systemic JAK inhibition makes local administration a more attractive option...
June 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28632888/excellent-response-to-tofacitinib-treatment-in-a-patient-with-alopecia-universalis
#11
Funda Erduran, Esra Adışen, Ahmet Burhan Aksakal
Alopecia universalis (AU) is generally considered a variant of alopecia areata (AA), in which the treatment options seldom provide satisfactory results. However, successful treatment of several cases of AA and its variants with oral Janus kinase (JAK) inhibitors have been reported recently. Here we report a 23-year-old female patient with AU successfully treated with tofacitinib, a selective JAK-3 inhibitor. The initial tofacitinib dose was 5 mg twice daily. After 2 months of treatment, partial hair regrowth was seen on the scalp and eyebrows...
June 2017: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/28627278/methotrexate-for-the-treatment-of-pediatric-alopecia-areata
#12
Erin T Landis, Rita O Pichardo-Geisinger
PURPOSE: Alopecia areata is a form of nonscarring hair loss that occurs in pediatric and adult patients, with presentation varying from round or ovoid patches of alopecia to alopecia totalis or universalis. While frustrating for patients, it can also be frustrating for clinicians to treat, as there is no definitive treatment. Dermatologists are very familiar with the use of methotrexate for psoriasis and other inflammatory skin diseases, and this medication is generally well tolerated in children...
June 30, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28536724/successful-hair-regrowth-in-a-korean-patient-with-alopecia-universalis-following-tofacitinib-treatment
#13
Bo Young Kim, Hyun-Sook Kim
No abstract text is available yet for this article.
May 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28515996/dermoscopy-of-alopecia-areata-a-retrospective-analysis
#14
Abhijeet K Jha, Uday K Udayan, P K Roy, Amar K J Amar, R K P Chaudhary
BACKGROUND: Dermoscopy devices can overcome the refractive properties of stratum corneum by interface medium or cross polarization such that the lesion can be easily seen. AIM: To examine the dermoscopic feature in alopecia areata and correlate the severity of disease with dermoscopic features. MATERIALS AND METHODS: Retrospective analysis of 72 patients suffering from alopecia areata (AA), irrespective of age and sex, who visited the dermatology outpatient department of a tertiary care center in Eastern India was carried out...
April 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/28492603/recovery-of-hair-in-the-psoriatic-plaques-of-a-patient-with-coexistent-alopecia-universalis
#15
Christine Anastasiou, Carolyn Goh, Vanessa Holland
No abstract text is available yet for this article.
April 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28378336/review-of-treatment-for-alopecia-totalis-and-alopecia-universalis
#16
REVIEW
Sama Kassira, Dorota Z Korta, Lance W Chapman, Francis Dann
Alopecia areata (AA) is an autoimmune disease directed at the hair follicle. Although usually limited to patchy hair loss over the scalp (focalis), AA can present as total loss of scalp hair (totalis; AT) or as total loss of both scalp and body hair (universalis; AU). Management of AT and AU can be challenging, and although multiple treatment modalities have been explored, no therapy is currently FDA-approved. This review focuses on the evidence for current treatment options for AT and AU. The PubMed database was searched from January 1, 2000, to September 1, 2016, for clinical trials, retrospective studies, and case reports of treatments for AT and AU...
August 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28349112/treatment-of-alopecia-universalis-with-oral-alitretinoin-a-case-report
#17
Pierre-Olivier Grenier, Hélène Veillette
No abstract text is available yet for this article.
March 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28329493/ichthyosis-follicularis-with-alopecia-and-photophobia-syndrome-ifap-a-case-report
#18
Bruno Ferrari, Lucila Morita, Keith Choate, Rong-Hua Hu
IFAP syndrome is a rare autosomal recessive X-linked disease characterized by the triad of alopecia universalis, severe photophobia, and follicular ichthyosis. It is caused by loss of function of the gene MBTPS2. Its severity varies and there are only a few reports in the literature. We present a patient with characteristic clinical features and a mutation not previously reported.
February 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28325392/experience-with-oral-tofacitinib-in-8-adolescent-patients-with-alopecia-universalis
#19
LETTER
Leslie Castelo-Soccio
No abstract text is available yet for this article.
April 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28322434/two-cases-of-alopecia-areata-treated-with-ruxolitinib-a%C3%A2-discussion-of-ideal-dosing-and-laboratory-monitoring
#20
Amy Vandiver, Nicholas Girardi, Jihad Alhariri, Luis A Garza
BACKGROUND: Alopecia areata is a relatively common condition affecting patients seen in community dermatology clinics. A 2014 study implicated the JAK1/JAK2 inhibitor, ruxolitinib in short-term treatment of alopecia, however little information exists about the long-term use in otherwise healthy individuals in the community setting. METHODS: A patient with chronic alopecia areata and a patient with acute onset alopecia universalis were treated with oral ruxolitinib for over a year...
March 21, 2017: International Journal of Dermatology
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