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endothelial function type diabetes

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https://www.readbyqxmd.com/read/28790929/combined-interval-training-and-post-exercise-nutrition-in-type-2-diabetes-a-randomized-control-trial
#1
Monique E Francois, Cody Durrer, Kevin J Pistawka, Frank A Halperin, Courtney Chang, Jonathan P Little
Background: High-intensity interval training (HIIT) can improve several aspects of cardiometabolic health. Previous studies have suggested that adaptations to exercise training can be augmented with post-exercise milk or protein consumption, but whether this nutritional strategy can impact the cardiometabolic adaptations to HIIT in type 2 diabetes is unknown. Objective: To determine if the addition of a post-exercise milk or protein beverage to a high-intensity interval training (HIIT) intervention improves cardiometabolic health in individuals with type 2 diabetes...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28781215/adipose-derived-stem-cell-derived-exosomes-ameliorate-erectile-dysfunction-in-a-rat-model-of-type-2-diabetes
#2
Fengzhi Chen, Haibo Zhang, Zhiqiang Wang, Wei Ding, Qinyu Zeng, Wenbing Liu, Can Huang, Shuhua He, Anyang Wei
BACKGROUND: The efficacy of adipose-derived stem cells (ADSCs) in alleviating erectile dysfunction (ED) of diabetic rats has been demonstrated mainly through a paracrine effect. However, exosomes (EXOs), which are important bioactive substance vectors secreted by ADSCs, have never been associated with ED. AIM: To investigate the effect of ADSC-derived EXOs on erectile function in a type 2 diabetic ED rat model. METHODS: EXOs were isolated from the supernatants of cultured ADSCs by ultracentrifugation...
August 3, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28774328/curcumin-induces-therapeutic-angiogenesis-in-a-diabetic-mouse-hindlimb-ischemia-model-via-modulating-the-function-of-endothelial-progenitor-cells
#3
Jinzhi You, Jiacheng Sun, Teng Ma, Ziying Yang, Xu Wang, Zhiwei Zhang, Jingjing Li, Longgang Wang, Masaaki Ii, Junjie Yang, Zhenya Shen
BACKGROUND: Neovascularization is impaired in diabetes mellitus, which leads to the development of peripheral arterial disease and is mainly attributed to the dysfunction of endothelial progenitor cells (EPCs). Previous studies proved the promotional effect of curcumin on neovascularization in wound healing of diabetes. Thus, we hypothesize that curcumin could promote neovascularization at sites of hindlimb ischemia in diabetes and might take effect via modulating the function of EPCs...
August 3, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28762906/-efficacy-of-short-term-therapy-with-meldonium-in-patients-with-chronic-heart-failure-of-ischemic-etiology-and-type-2-diabetes-mellitus
#4
Statsenko Statsenko, S V Turkin, S V Fabritskaya, N N Shilina
PURPOSE: to assess efficacy and endotheliotropic properties of short-term addition of meldonium to basic therapy of patients with chronic ischemic heart failure and type 2 diabetes. RESULTS AND CONCLUSION: The study demonstrated the ability of meldonium to significantly improve endothelial function and the state of microcirculatory vascular bed, as well as to influence beneficially heart rate variability.
April 2017: Kardiologiia
https://www.readbyqxmd.com/read/28760408/relationship-between-serum-inflammatory-markers-and-vascular-function-in-a-cohort-of-adolescents-with-type-1-diabetes
#5
Etienne Sochett, Damien Noone, Michael Grattan, Cameron Slorach, Rahim Moineddin, Yesmino Elia, Farid H Mahmud, David B Dunger, Neil Dalton, David Cherney, James Scholey, Heather Reich, John Deanfield
OBJECTIVE: The contribution of inflammation to endothelial/vascular dysfunction in early Type I Diabetes (T1D) is not well understood. The objective of this study was to examine the interaction between systemic inflammation and vascular function in adolescent's with and without-T1D. METHODS: 51 subjects from our observational cohort of adolescents with T1D (JDRF-CCTN), and 59 healthy controls (HC) were studied. Serum cytokines-chemokines were quantified using Human 41-Plex Array, and vascular function was measured by Flow Mediated Dilatation (FMD), Pulse Wave Velocity (PWV) and Blood Pressure (BP)...
July 28, 2017: Cytokine
https://www.readbyqxmd.com/read/28750431/nitric-oxide-plasma-level-as-a-barometer-of-endothelial-dysfunction-in-factory-workers
#6
Seiko Miyata, Akiko Noda, Yuki Hara, Jun Ueyama, Kiyoyuki Kitaichi, Takaaki Kondo, Yasuo Koike
Objective Nitric oxide (NO) plays a key role in the regulation of vascular tone and is known as one of the key markers of endothelial dysfunction. We investigated the relationship between NO and risk factors of lifestyle-related disease in factory workers. Methods Our study included 877 factory workers presenting hypertension, dyslipidemia and type 2 diabetes. oxidated forms of NO, NO2-/NO3- (NOx) plasma concentrations were measured using a colorimetric method. Results NOx plasma levels in patients with lifestyle-related disease were significantly lower than those in the controls...
July 27, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28739650/lysophosphatidic-acid-receptor-antagonism-protects-against-diabetic-nephropathy-in-a-type-2-diabetic-model
#7
Ming-Zhi Zhang, Xin Wang, Haichun Yang, Agnes B Fogo, Brian J Murphy, Robert Kaltenbach, Peter Cheng, Bradley Zinker, Raymond C Harris
Lysophosphatidic acid (LPA) functions through activation of LPA receptors (LPARs). LPA-LPAR signaling has been implicated in development of fibrosis. However, the role of LPA-LPAR signaling in development of diabetic nephropathy (DN) has not been studied. We examined whether BMS002, a novel dual LPAR1 and LPAR3 antagonist, affects development of DN in endothelial nitric oxide synthase-knockout db/db mice. Treatment of these mice with BMS002 from 8 to 20 weeks of age led to a significant reduction in albuminuria, similar to that observed with renin-angiotensin system inhibition (losartan plus enalapril)...
July 24, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28732797/functional-convergence-of-akt-protein-with-vegfr-1-in-human-endothelial-progenitor-cells-exposed-to-sera-from-patient-with-type-2-diabetes-mellitus
#8
Mehdi Hassanpour, Aysa Rezabakhsh, Reza Rahbarghazi, Alireza Nourazarian, Mohammad Nouri, Çığır Biray Avci, Shahrooz Ghaderi, Neda Alidadyani, Bakiye Goker Bagca, Hesam Saghaei Bagheri
Diabetes mellitus type 2 predisposes patients to various microvascular complications. In the current experiment, the potent role of diabetes mellitus was investigated on the content of VEGFR-1, -2, Tie-1 and -2, and Akt in human endothelial progenitor cells. The gene expression profile of mTOR and Hedgehog signaling pathways were measured by PCR array. The possible crosstalk between RTKs, mTOR and Hedgehog signaling was also studied by bioinformatic analysis. Endothelial progenitor cells were incubated with serum from normal and diabetic for 7days...
July 18, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28732591/diabetic-retinopathy-breaking-the-barrier
#9
REVIEW
Randa S Eshaq, Alaa M Z Aldalati, J Steven Alexander, Norman R Harris
Diabetic retinopathy (DR) remains a major complication of diabetes and a leading cause of blindness among adults worldwide. DR is a progressive disease affecting both type I and type II diabetic patients at any stage of the disease, and targets the retinal microvasculature. DR results from multiple biochemical, molecular and pathophysiological changes to the retinal vasculature, which affect both microcirculatory functions and ultimately photoreceptor function. Several neural, endothelial, and support cell (e...
July 12, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28724057/impaired-flow-mediated-dilation-response-and-carotid-intima-media-thickness-in-patients-with-type-1-diabetes-mellitus-with-a-mean-disease-duration-of-4-1-years
#10
Lúcia Helena Bonalume Tacito, Antonio Carlos Pires, Juan Carlos Yugar-Toledo
Objective: This study aimed at assessing the endothelial function in patients with Type 1 diabetes (T1DM) using flow-mediated dilation (FMD) response and carotid artery intima-media thickness (CIMT). Materials and methods: This study enrolled 32 T1DM patients (mean disease duration 4.1 years) and 28 age-matched controls (CTL Group). Endothelial function and CIMT were assessed with high-resolution ultrasound using standardized offline measurements. Results: FMD was significantly lower in patients in the T1DM Group (8...
July 13, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28700893/coronary-microvascular-disease-as-an-early-culprit-in-the-pathophysiology-of-diabetes-and-metabolic-syndrome
#11
REVIEW
Hicham Labazi, Aaron J Trask
Metabolic syndrome (MetS) is a group of cardio-metabolic risk factors that includes obesity, insulin resistance, hypertension, and dyslipidemia; these are also a combination of independent coronary artery disease (CAD) risk factors. Alarmingly, the prevalence of MetS risk factors are increasing and a leading cause for mortality. In the vasculature, complications from MetS and type 2 diabetes (T2D) can be divided into microvascular (retinopathy and nephropathy) and macrovascular (cardiovascular diseases and erectile dysfunction)...
July 9, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28686848/transcriptional-regulation-of-endmt-in-cardiac-fibrosis-role-of-mrtf-a-and-atf3
#12
Vibhuti Sharma, Nilambra Dogra, Uma Saikia, Madhu Khullar
The etiology of cardiac fibrogenesis is quite diverse but a common feature is the presence of activated fibroblasts. Experimental evidence suggests that a subset of cardiac fibroblasts is derived via transition of vascular endothelial cells into fibroblasts by endothelial to mesenchymal transition (EndMT). During EndMT, endothelial cells lose their endothelial characteristics and acquire a mesenchymal phenotype. Molecular mechanisms and the transcriptional mediators controlling EndMT in heart during development or disease remain relatively undefined...
July 7, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28685678/glomerular-endothelium-and-its-impact-on-glomerular-filtration-barrier-in-diabetes-are-the-gaps-still-illusive
#13
Joseph Fomusi Ndisang
BACKGROUND: Glomerular capillaries are lined with highly specialized fenestrated endothelium which are primarily responsible to regulate high flux filtration of fluid and small solutes. During filtration, plasma passes through the fenestrated endothelium and basement membrane before it reaches the slit diaphragm, a specialized type of intercellular junction that connects neighbouring podocytes. METHODS: A PubMed search was done for recent articles on components of the glomerular filtration barrier such as glomerular endothelial cells, podocytes and glomerular basement membrane, and the effect of diabetes on these structures...
July 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28683796/effectiveness-of-dapagliflozin-on-vascular-endothelial-function-and-glycemic-control-in-patients-with-early-stage-type-2-diabetes-mellitus-defence-study
#14
Fumika Shigiyama, Naoki Kumashiro, Masahiko Miyagi, Kayoko Ikehara, Eiichiro Kanda, Hiroshi Uchino, Takahisa Hirose
BACKGROUND: Recent studies reported that sodium glucose cotransporter 2 (SGLT2) inhibitors can potentially reduce the risk of cardiovascular mortality in patients with type 2 diabetes mellitus (T2DM). However, there is little or no information on the therapeutic effects of SGLT2 inhibitors on the progression of atherosclerosis. This dapagliflozin effectiveness on vascular endothelial function and glycemic control (DEFENCE) study was designed to determine the effects of dapagliflozin, a SGLT2 inhibitor, on endothelial function in patients with early-stage T2DM...
July 6, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28667906/the-sglt2-inhibitor-empagliflozin-improves-the-primary-diabetic-complications-in-zdf-rats
#15
Sebastian Steven, Matthias Oelze, Alina Hanf, Swenja Kröller-Schön, Fatemeh Kashani, Siyer Roohani, Philipp Welschof, Maximilian Kopp, Ute Gödtel-Armbrust, Ning Xia, Huige Li, Eberhard Schulz, Karl J Lackner, Leszek Wojnowski, Serge P Bottari, Philip Wenzel, Eric Mayoux, Thomas Münzel, Andreas Daiber
Hyperglycemia associated with inflammation and oxidative stress is a major cause of vascular dysfunction and cardiovascular disease in diabetes. Recent data reports that a selective sodium-glucose co-transporter 2 inhibitor (SGLT2i), empagliflozin (Jardiance(®)), ameliorates glucotoxicity via excretion of excess glucose in urine (glucosuria) and significantly improves cardiovascular mortality in type 2 diabetes mellitus (T2DM). The overarching hypothesis is that hyperglycemia and glucotoxicity are upstream of all other complications seen in diabetes...
June 22, 2017: Redox Biology
https://www.readbyqxmd.com/read/28662074/fiber-rich-diet-with-brown-rice-improves-endothelial-function-in-type-2-diabetes-mellitus-a-randomized-controlled-trial
#16
Keiko Kondo, Katsutaro Morino, Yoshihiko Nishio, Atsushi Ishikado, Hisatomi Arima, Keiko Nakao, Fumiyuki Nakagawa, Fumio Nikami, Osamu Sekine, Ken-Ichi Nemoto, Makoto Suwa, Motonobu Matsumoto, Katsuyuki Miura, Taketoshi Makino, Satoshi Ugi, Hiroshi Maegawa
BACKGROUND & AIMS: A fiber-rich diet has a cardioprotective effect, but the mechanism for this remains unclear. We hypothesized that a fiber-rich diet with brown rice improves endothelial function in patients with type 2 diabetes mellitus. METHODS: Twenty-eight patients with type 2 diabetes mellitus at a single general hospital in Japan were randomly assigned to a brown rice (n = 14) or white rice (n = 14) diet and were followed for 8 weeks. The primary outcome was changes in endothelial function determined from flow debt repayment by reactive hyperemia using strain-gauge plethysmography in the fasting state...
2017: PloS One
https://www.readbyqxmd.com/read/28659817/cobalt-chloride-upregulates-impaired-hif-1%C3%AE-expression-to-restore-sevoflurane-post-conditioning-dependent-myocardial-protection-in-diabetic-rats
#17
Jianjiang Wu, Long Yang, Peng Xie, Jin Yu, Tian Yu, Haiying Wang, Yiliyaer Maimaitili, Jiang Wang, Haiping Ma, Yining Yang, Hong Zheng
Previous studies from our group have demonstrated that sevoflurane post-conditioning (SPC) protects against myocardial ischemia reperfusion injury via elevating the intranuclear expression of hypoxia inducible factor-1 alpha (HIF-1α). However, diabetic SPC is associated with decreased myocardial protection and disruption of the HIF-1 signaling pathway. Previous studies have demonstrated that cobalt chloride (CoCl2) can upregulate HIF-1α expression under diabetic conditions, but whether myocardial protection by SPC can be restored afterward remains unclear...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28659030/tongxinluo-inhibits-renal-fibrosis-in-diabetic-nephropathy-involvement-of-the-suppression-of-intercellular-transfer-of-tgf-formula-see-text-1-containing-exosomes-from-gecs-to-gmcs
#18
Xiao-Ming Wu, Yan-Bin Gao, Li-Ping Xu, Da-Wei Zou, Zhi-Yao Zhu, Xiao-Lei Wang, Wei-Jie Yao, Liang-Tao Luo, Yu Tong, Nian-Xiu Tian, Zhe-Ji Han, Wan-Yu Dang
Glomerular mesangial cells (GMCs) activation is implicated in the pathogenesis of diabetic nephropathy (DN). Our previous study revealed that high glucose (HG)-treated glomerular endothelial cells (GECs) produce an increased number of TGF-β1-containing exosomes to activate GMCs through the TGF-β1/Smad3 signaling pathway. We also identified that Tongxinluo (TXL), a traditional Chinese medicine, has beneficial effects on the treatment of DN in DN patients and type 2 diabetic mice. However, it remained elusive whether TXL could ameliorate renal structure and function through suppression of intercellular transfer of TGF-β1-containing exosomes from GECs to GMCs...
June 28, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28651343/does-a-first-degree-family-history-of-diabetes-impact-placental-maternal-and-fetal-vascular-circulation-and-inflammatory-response
#19
Marina Shargorodsky, Michal Kovo, Letizia Schraiber, Jacob Bar
Context: Heritability of diabetes is associated with hyperinsulinemia, impaired endothelial function, and inflammatory up-regulation. However, no studies have examined whether a family history of diabetes effects placental vascular circulation. Objective: The present study was designed to investigate the impact of a first-degree family history of type 2 diabetes (FHD) on placental vascular circulation and inflammatory lesions. Design: Observational cohort study...
June 23, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28645936/angiopoietin-like-protein-4-is-a-high-density-lipoprotein-hdl-component-for-hdl-metabolism-and-function-in-nondiabetic-participants-and-type-2-diabetic-patients
#20
Long-Yan Yang, Cai-Guo Yu, Xu-Hong Wang, Sha-Sha Yuan, Li-Jie Zhang, Jia-Nan Lang, Dong Zhao, Ying-Mei Feng
BACKGROUND: ANGPTL4 (angiopoietin-like protein 4) is a LPL (lipoprotein lipase) inhibitor and is present in high-density lipoprotein (HDL). However, it is not defined whether ANGPTL4 in HDLs could affect HDL metabolism and function in type 2 diabetes mellitus (T2DM). METHODS AND RESULTS: ANGPTL4 levels in the circulation and HDLs were quantified in nondiabetic participants (n=201, 68.7% females) and T2DM patients (n=185, 66.5% females). HDLs were isolated from nondiabetic controls and T2DM patients to assess cholesterol efflux or subjected to endothelial lipase (EL)-overexpressed HEK293 cells for EL hydrolysis in vitro...
June 23, 2017: Journal of the American Heart Association
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