Shuoji Zhu, Changjiang Yu, Mingyi Zhao, Nanbo Liu, ZeRui Chen, Jian Liu, Ge Li, Yuzhi Deng, Xiyalatu Sai, Huanlei Huang, Huiming Guo, Chen Chen, Xiaowu Wang, Yuanyuan Zheng, Tucheng Sun, Jimei Chen, Jian Zhuang, Ping Zhu
Micro-/macroangiopathy, neuropathy and prolonged inflammation are common in diabetic wound, however, traditional wound dressing cannot treat these problems in the same time. Herein, we developed a multifunctional hydrogel with promoted angiogenesis, cell proliferation and anti-inflammation ability to treat diabetic wound. The hydrogel was composed of natural polymers, including gelatin and chitosan, which have excellent biocompatibility. Histatin-1 (His-1) was added into the hydrogel to improve the cell adhesion, proliferation and angiogenesis...
June 1, 2022: International Journal of Biological Macromolecules