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micro and macroangiopathy

Rigas G Kalaitzidis, Moses S Elisaf
Angiogenesis is fundamental for tumour development and progression. Thus, anti-angiogenic agents have been developed and are mainly vascular endothelial growth factor (VEGF) pathway inhibitors. However, these agents commonly exhibit cardiac and renal toxicity, proteinuria and hypertension (HT). In fact, with the use of anti-angiogenic agents a rapiddose-dependent increaseof blood pressure (BP) is observed. Thepossible mechanisms of VEGF inhibitors-induced HTinclude systemic endothelial dysfunction, renal impairment as well as vascular micro- and macroangiopathy...
April 14, 2017: Current Vascular Pharmacology
Kornél Simon, István Wittmann
In clinical recommendations the normalized blood glucose level is declared as the main target in therapy of diabetes mellitus, i.e. the achievement of euglycemia is the main therapeutic goal. This approach suggests, that the normal blood glucose value is the marker of the normal carbohydrate metabolism (eumetabolism), and vice versa: hyperglycemia is associated with abnormal metabolism (dysmetabolism). However the question arises, whether identical blood glucose values do reflect the same intracellular biochemical mechanisms? On the basis of data published in the literature authors try to answer these questions by studying the relations between the short/longterm blood glucose level and the cellular metabolism in different clinical settings characterized by divergent pathophysiological parameters...
March 2017: Orvosi Hetilap
A Herrero, J Pinillos, P Sabio, J L Martín, G Garzón, Á Gil
INTRODUCTION: There is evidence of increased macro- and micro-vascular risk in diabetic patients. The objective of this study was to determine the level of control in patients in different population groups with type 2 diabetes. MATERIAL AND METHODS: HASH(0x3832738) DESIGN: Descriptive cross-sectional study. LOCATION: Primary care. Madrid Health Service. Year: 2014. SUBJECTS: Patients over 14 years with type 2 diabetes...
November 23, 2016: Semergen
Olga Reichert, Thomas Fleming, Gitta Neufang, Martin Schmelz, Harald Genth, Volkhard Kaever, Horst Wenck, Franz Stäb, Lara Terstegen, Ludger Kolbe, Dennis Roggenkamp
Patients suffering from type II diabetes develop several skin manifestations including cutaneous infections, diabetic dermopathy, diabetic bullae and acanthosis nigricans. Diabetic micro- and macroangiopathy as well as diabetic neuropathy are believed to play a crucial role in the development of diabetic skin disorders. A reduced cutaneous nerve fibre density was reported in diabetic subjects, which subsequently leads to impaired sensory nerve functions. Using an innervated skin model, we investigated the impact of human diabetic dermal fibroblasts and keratinocytes on porcine sensory neurons...
January 2017: Experimental Dermatology
Josef Finsterer, Sinda Zarrouk-Mahjoub
Mitochondrial disorders (MIDs) are usually multisystem disorders (mitochondrial multiorgan disorder syndrome) either on from onset or starting at a point during the disease course. Most frequently affected tissues are those with a high oxygen demand such as the central nervous system, the muscle, endocrine glands, or the myocardium. Recently, it has been shown that rarely also the arteries may be affected (mitochondrial arteriopathy). This review focuses on the type, diagnosis, and treatment of mitochondrial vasculopathy in MID patients...
May 26, 2016: World Journal of Cardiology
Michel P Hermans, K Daniel Amoussou-Guenou, Evariste Bouenizabila, Shaukat S Sadikot, Sylvie A Ahn, Michel F Rousseau
BACKGROUND: Type 2 diabetes (T2DM) is associated with obesity, insulin resistance and the metabolic syndrome (MetS). In non-diabetic populations, features of metabolic obesity (MO) are observed in a minority of normal-weight (NW) subjects. The cardiometabolic status of metabolically obese but normal-weight (MONW) individuals has not yet been phenotyped in T2DM. PATIENTS AND METHODS: Prevalence and features of MONW were analyzed in 1244 T2DM patients, in whom MONW was identified as a BMI <25...
April 2016: Diabetes & Metabolic Syndrome
Hiroyuki Ito, Takashi Omoto, Mariko Abe, Suzuko Matsumoto, Masahiro Shinozaki, Shinya Nishio, Shinichi Antoku, Mizuo Mifune, Michiko Togane
AIMS: The aim of the present study was to clarify the relationships between the duration of diabetes and the current statuses of diabetes in elderly (aged ≥65 years) patients with type 2 diabetes. METHODS: Clinical characteristics were cross-sectionally examined in 1436 patients (684 elderly and 752 non-elderly) with type 2 diabetes. RESULTS: As the duration of diabetes increased, the patients' age, frequency of receiving insulin therapy and glycated hemoglobin value increased in both the elderly and non-elderly groups, whereas the urinary C-peptide immunoreactivity and glomerular filtration rate decreased...
December 4, 2015: Geriatrics & Gerontology International
Sho-ichi Yamagishi, Takanori Matsui
Diabetic micro- and macroangiopathy are devastating vascular complications that could account for disabilities and high mortality rate in patients with diabetes. Indeed, diabetic nephropathy and retinopathy are the leading causes of end-stage renal failure and acquired blindness, respectively, and atherosclerotic cardiovascular diseases (CVD) accounts for about 60% of death in diabetic subjects. As a result, the average life span of diabetic patients is about 10-15 years shorter than that of non-diabetic subjects...
April 2016: Rejuvenation Research
John Doupis, Aristidis Veves
The diabetic foot is one of the most significant complications of diabetes and is considered to be a major medical, social, and economic problem worldwide. The risk for foot ulceration in patients with diabetes is close to 25% and is also closely related to risk of limb amputation. Diabetic neuropathy, limited joint mobility, micro- and macroangiopathy, and high plantar pressures have been described as the main risk factors for diabetic foot ulceration. Proper diagnosis and adequate therapeutic treatment are considered the cornerstones to prevention of limb amputation and preservation of quality of life in patients with diabetes...
May 2008: Wounds: a Compendium of Clinical Research and Practice
Gian Paolo Fadini, Francesca Ferraro, Federico Quaini, Takayuki Asahara, Paolo Madeddu
Diabetes mellitus is a global health problem that results in multiorgan complications leading to high morbidity and mortality. Until recently, the effects of diabetes and hyperglycemia on the bone marrow microenvironment-a site where multiple organ systems converge and communicate-have been underappreciated. However, several new studies in mice, rats, and humans reveal that diabetes leads to multiple bone marrow microenvironmental defects, such as small vessel disease (microangiopathy), nerve terminal pauperization (neuropathy), and impaired stem cell mobilization (mobilopathy)...
August 2014: Stem Cells Translational Medicine
Barbara Ruszkowska-Ciastek, Alina Sokup, Maciej W Socha, Zofia Ruprecht, Lidia Hałas, Barbara Góralczyk, Krzysztof Góralczyk, Grażyna Gadomska, Danuta Rość
OBJECTIVE: Decompensated chronic hyperglycemia often leads to late microvascular complications such as retinopathy, diabetic foot syndrome, and diabetic kidney disease. The aim of this study was to determine the concentration of vascular endothelial growth factor A (VEGF-A) and its receptors in patients with well-controlled diabetes. METHODS: The study was conducted on 31 patients with well-controlled type 2 diabetes without micro- or macroangiopathy. Thirty healthy volunteers were enrolled in a control group...
June 2014: Journal of Zhejiang University. Science. B
Hiroyuki Ito, Yuichiro Takeuchi, Hidenori Ishida, Aya Otawa, Akane Shibayama, Shinichi Antoku, Mariko Abe, Mizuo Mifune, Michiko Togane
UNLABELLED: Aims/Introduction:  The present study investigated the frequency of mild anemia, which is not an indication of intensive therapy using drugs, in Japanese patients with type 2 diabetes mellitus and the association of mild anemia with diabetic complications. MATERIALS AND METHODS:   This is a cross-sectional study of 1189 patients with type 2 diabetes mellitus. Anemia was defined as a hemoglobin level <13.5 g/dL in men and <12.0 g/dL in women...
December 3, 2010: Journal of Diabetes Investigation
Michel P Hermans, Yovan P Mahadeb, Philippe Katchunga, Justin Cikomola Cirhuza, Sylvie A Ahn, Michel F Rousseau
BACKGROUND: OSAS, a frequently neglected, yet frequent comorbidity in T2DM, is associated with obesity, metabolic syndrome and central fat. OSAS is better documented in males, and this study explored novel gender dimorphisms in T2DM. METHODS: Cross-sectional study: 815 T2DM (541 males; 274 females) classified into OSAS[-] and OSAS[+] were assessed for cardiometabolic risk factors, glucose homeostasis, micro/macroangiopathies, CV risk, autoimmune thyroid disease (AITD); and GAD65 antibodies...
January 2014: Diabetes & Metabolic Syndrome
Nelli Farkas, Andrea Szabó, Veronika Lóránd, Donát Péter Sarlós, Tünde Minier, Zoltán Prohászka, László Czirják, Cecília Varjú
OBJECTIVE: Red blood cell distribution width (RDW) is a biomarker quantifying the variability of red blood cell size in peripheral blood. Elevated RDW has been found to be an independent prognostic factor for cardiovascular events. SSc is characterized by generalized micro- and macroangiopathy. Our aim was to investigate RDW as a potential biomarker for the assessment of the severity of vascular involvement. METHODS: One hundred and sixty-eight consecutive SSc patients--62 with dcSSc and 106 with lcSSc--were investigated at baseline and after 1-year of follow-up...
August 2014: Rheumatology
Akihiro Shindo, Hidekazu Tomimoto
Diabetes mellitus is an established risk factor for coronary artery disease and ischemic stroke, and can induce micro- and macroangiopathy. Stroke is strongly associated with severe disability and mortality in Japan, and the risk of stroke is 2-4 times higher among patients with diabetes than among matched controls. The abnormal metabolic state in diabetes can cause arterial dysfunction, and patients with diabetes require treatment for each metabolic abnormality to attenuate atherogenesis. Moreover, diabetes affects stroke outcome as well...
February 2014: Brain and Nerve, Shinkei Kenkyū No Shinpo
Jerzy Kotlinowski, Józef Dulak, Alicja Józkowicz
Type 2 diabetes mellitus (T2DM) is a metabolic disease caused by insulin resistance that leads to changes in glucose metabolism. Importantly, both insulin resistance and hyperglycemia are present in T2DM patients as a hallmarks of metabolic syndrome. They negatively affect functions of many cells, for example endothelial cells. Endothelial progenitor cells (EPC) is a population of mononuclear cells that expresses endothelial and progenitor markers. EPC are also characterized by ability to form tubes on matrigel, outgrowth into mature endothelial cells, produce proangiogenic factors or take part in the blood vessels formation...
2013: Postepy Biochemii
A A Nelaeva, Iu V Khasanova, E S Khobotova
Diabetes mellitus is a systemic lesion of the micro- and macrocirculatory bed. We examined a total of 110 people with type 2 diabetes mellitus and lesions of the major vessels of the lower limbs. Of these, 70 patients were found to have microangiopathy combined with nephropathy. Diabetic nephropathy was classified depending on the level of microalbuminuria and the glomerular filtration rate. All patients were subdivided into three groups: diabetic macroangiopathy of the lower extremities with neither diabetic nephropathy nor chronic renal disease, lower-limb diabetic macroangiopathy combined with diabetic nephropathy in stage 1 of microalbuminuria of chronic renal disease and those in combination with diabetic nephropathy in stage 2 of microalbuminuria chronic renal disease...
2013: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
D Dakovic, M Colic, S Cakic, I Mileusnic, Z Hajdukovic, N Stamatovic
OBJECTIVE: The aim of this study was to investigate the differences between the salivary levels of IL-8 in patients with Type 1 diabetes mellitus (DM) with (DM+P) or without (DM-P) concomitant periodontitis and healthy subjects. The correlations between the levels of these cytokines and clinical periodontal parameters were also established. METHODS: Twenty children and adolescents with Type 1 DM (10 diagnosed with periodontitis, 10 presenting no signs of periodontitis) and a control group consisting of 20 healthy children and adolescents aged 7-18 years were recruited for this study...
2013: Journal of Clinical Pediatric Dentistry
Béatrice Bouhanick, Mohamed Barigou, Jean-Baptiste Kantambadouno, Bernard Chamontin
In France, 2.8 millions of patients have type 2 diabetes, which is a well-established risk factor for cardiovascular disease. In about 15 years, several large clinical trials tried to study the relationship between a tight glycaemic control and the occurrence of micro- and macroangiopathy. Meta-analyses of targeting intensive versus conventional glycaemic control focused on divergent results. In type 1 diabetes, a tight glycaemic control reduced the occurrence of microangiopathy whereas more time, at least 5 years is needed to reduce macroangiopathy...
May 2013: La Presse Médicale
Antonino Tuttolomondo, Rosaria Pecoraro, Irene Simonetta, Salvatore Miceli, Valentina Arnao, Giuseppe Licata, Antonio Pinto
Characteristic clinical manifestations of AFD such as acroparesthesias, angiokeratoma, corneal opacity, hypo/ and anhidrosis, gastrointestinal symptoms, renal and cardiac dysfunctions can occur in male and female patients, although heterozygous females with AFD usually seem to be less severely affected. The most prominent CNS manifestations consist of cerebrovascular events such as transient ischaemic attacks (TIAs) and (recurrent) strokes. For the most part, CNS complications in AFD have been attributed to cerebral vasculopathy, including anatomical abnormalities...
2013: Current Pharmaceutical Design
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