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https://www.readbyqxmd.com/read/27193298/pacrg-a-protein-linked-to-ciliary-motility-mediates-cellular-signaling
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Catrina M Loucks, Nathan J Bialas, Martijn P J Dekkers, Denise S Walker, Laura J Grundy, Chunmei Li, P Nick Inglis, Katarzyna Kida, William R Schafer, Oliver E Blacque, Gert Jansen, Michel R Leroux
Cilia are microtubule-based organelles that project from nearly all mammalian cell types. Motile cilia generate fluid flow, whereas nonmotile (primary) cilia are required for sensory physiology and modulate various signal transduction pathways. Here we investigate the nonmotile ciliary signaling roles of parkin coregulated gene (PACRG), a protein linked to ciliary motility. PACRG is associated with the protofilament ribbon, a structure believed to dictate the regular arrangement of motility-associated ciliary components...
July 1, 2016: Molecular Biology of the Cell
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