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https://www.readbyqxmd.com/read/28719856/contribution-of-kupffer-cells-to-liposome-accumulation-in-the-liver
#1
Emma Samuelsson, Haifa Shen, Elvin Blanco, Mauro Ferrari, Joy Wolfram
The liver is a major barrier for site-specific delivery of systemically injected nanoparticles, as up to 90% of the dose is usually captured by this organ. Kupffer cells are thought to be the main cellular component responsible for nanoparticle accumulation in the liver. These resident macrophages form part of the mononuclear phagocyte system, which recognizes and engulfs foreign bodies in the circulatory system. In this study, we have compared two strategies for reducing nanoparticle accumulation in the liver, in order to investigate the specific contribution of Kupffer cells...
July 15, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28716104/evaluating-the-potential-of-gold-silver-and-silica-nanoparticles-to-saturate-mononuclear-phagocytic-system-tissues-under-repeat-dosing-conditions
#2
James L Weaver, Grainne A Tobin, Taylor Ingle, Simona Bancos, David Stevens, Rodney Rouse, Kristina E Howard, David Goodwin, Alan Knapton, Xiaohong Li, Katherine Shea, Sharron Stewart, Lin Xu, Peter L Goering, Qin Zhang, Paul C Howard, Jessie Collins, Saeed Khan, Kidon Sung, Katherine M Tyner
BACKGROUND: As nanoparticles (NPs) become more prevalent in the pharmaceutical industry, questions have arisen from both industry and regulatory stakeholders about the long term effects of these materials. This study was designed to evaluate whether gold (10 nm), silver (50 nm), or silica (10 nm) nanoparticles administered intravenously to mice for up to 8 weeks at doses known to be sub-toxic (non-toxic at single acute or repeat dosing levels) and clinically relevant could produce significant bioaccumulation in liver and spleen macrophages...
July 17, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28715682/cath-2-and-ll-37-increase-mannose-receptor-expression-antigen-presentation-and-the-endocytic-capacity-of-chicken-mononuclear-phagocytes
#3
Marina D Kraaij, Albert van Dijk, Henk P Haagsman
Cathelicidins display in vitro and in vivo immunomodulatory activities and are part of the innate immune system. Previously, we found that in ovo treatment with chicken cathelicidin CATH-2 partially protects young broilers against respiratory E. coli infection. To determine the cellular aspects of this protection, we investigated immunomodulatory effects of CATH-2 and the human cathelicidin LL-37 on primary chicken peripheral blood mononuclear cells (PBMCs). Treatment of chicken PBMCs with L-CATH-2, D-CATH-2 or LL-37 increased the percentage of mononuclear phagocytes, but decreased that of B cells...
July 14, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28701048/an-overview-of-nanosomes-delivery-mechanisms-trafficking-orders-barriers-and-cellular-effects
#4
Gamaleldin I Harisa, Mohamed M Badran, Fars K Alanazi, Sabry M Attia
This review traces the journey of nanosomes from administration until elimination, and discusses various biological barriers. The nanosomes are imported into the body through different routes and are localized into specified organ, cell, subcellular locations or organelle compartment. The nanosomes delivery to a specific destination depends on the surface chemistry, size, shape and the presence of specific ligands. Endocytosis/exocytosis cycles are involved in the import and export of the nanosomes. The mononuclear phagocytic system and ATP-binding cassette are universal checkpoints for nanosomes trafficking...
July 13, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28699500/cell-derived-exosomes-as-promising-carriers-for-drug-delivery-and-targeted-therapy
#5
Xinyi Wang, Haiyang Zhang, Haiou Yang, Ming Bai, Tao Ning, Shuang Li, Jialu Li, Ting Deng, Guoguang Ying, Yi Ba
Exosomes are small vesicles that are secreted by various types of cells, known to mediate signal transduction between cells. During recent years, novel carriers for the delivery of targeted drugs, chemotherapy drugs and RNAs are under development, which is believed to be beneficial for patients. Considering issues of drug nano-formulations in bloodstream, such as nano-toxicity and rapid clearance by mononuclear phagocyte system, exosomes derived from either patient's cells or bodyfluids, seem to be an optimal option...
July 10, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28699057/the-role-of-lipid-bodies-in-the-microglial-aging-process-and-related-diseases
#6
REVIEW
Xirong Hu, Benhong Xu, Wei Ge
Lipid bodies (LBs) have long been considered to be organelles merely for the storage of neutral lipids. However, recent studies have shown the significance of LBs in signal transduction, especially in glial cells, including microglia. Microglial cells are the resident mononuclear phagocytes in the central nervous system and have a close relationship with the aging process and neurodegenerative diseases. Evidence suggests that LBs accumulate and are remodeled during the aging process and the development of neuroinflammatory conditions...
July 11, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28697439/targeting-dendritic-cells-for-the-treatment-of-autoimmune-disorders
#7
REVIEW
C Sousa, I Pereira, A C Santos, C Carbone, A B Kovačević, A M Silva, E B Souto
In the last decades, it has been recognized that extracellular vesicles (EVs) are not only cell debris with no biological role, but instead they play a key role in information exchange between cells either in health and disease conditions. EVs exhibit indeed their biological role in a pleiotropic manner. They can modulate immune responses through the activation, transfer or removal of surface receptors on target cells, the removal of cytolytic components such as membrane attack complexes, and the transfer of signaling molecules/effectors, such as nucleic acid species, infectious particles, and oncogenes...
June 30, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28690898/delayed-treatment-response-in-a-neonate-with-multisystem-langerhans-cell-histiocytosis-case-report-and-review-of-literature
#8
Amitabh Singh, Anirban Mandal, Lavleen Singh, Sataroopa Mishra, Ankita Patel
Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of the Langerhans cells, which are part of the mononuclear phagocytic system. The disorder varies in terms of the extent of the disease, its natural course and patient outcomes. While skin rashes are a common presentation of neonatal LCH, other systems or organs may also be involved. Delays in the diagnosis of neonatal LCH may occur due to its non-specific presentation and a lack of awareness of the condition among doctors. We report a two-month-old male neonate who presented to the Chacha Nehru Bal Chikitsalya hospital, New Delhi, India, in 2016 after the onset of pulmonary symptoms...
May 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/28682598/multistage-passive-and-active-delivery-of-radiolabeled-nanogels-for-superior-tumor-penetration-efficiency
#9
Natascha Drude, Smriti Singh, Oliver Horst Winz, Martin Moeller, Felix Manuel Mottaghy, Agnieszka Morgenroth
Development of nanosized drug delivery systems in cancer therapy is directed towards improving tumor selectivity and minimizing damages of healthy tissue. We introduce a delivery system with synergistic optimization and combination of passive and active targeting strategies. The approach is based on radiopeptide labeled redox sensitive hydrophilic nanogels, which exploit passive targeting by the enhanced permeability and retention effect while avoiding elimination by the mononuclear phagocyte system and fast hepatic and/or renal clearance...
July 6, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28678945/phagocytosis-and-nitric-oxide-production-by-peritoneal-adherent-cells-in-response-to-candida-albicans-in-aging-a-collaboration-to-elucidate-the-pathogenesis-of-denture-stomatitis
#10
Taiane Priscila Gardizani, Karen Henriette Pinke, Heliton Gustavo de Lima, Vanessa Soares Lara
Objective: The aim of this study was to investigate the influence of aging on the internalization and the production of nitric oxide (NO) by peritoneal adherent cells (PAC), in response to Candida albicans (C. albicans). Material and methods: PAC obtained from young and aged mice were challenged with dead or viable C. albicans by using predetermined proportions (cells:yeast) for 30 and 120 minutes. Phagocytosis was analyzed by acridine orange dye, and NO production by the Griess reaction...
May 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28652078/extracellular-cytochrome-c-as-an-intercellular-signaling-molecule-regulating-microglial-functions
#11
Ayden Gouveia, Ekta Bajwa, Andis Klegeris
BACKGROUND: Cytochrome c is well known to be released from mitochondria into the cytosol where it can initiate apoptosis. Recent studies indicate that cytochrome c is also released into the extracellular space by both healthy and damaged cells, where its function is not well understood. We hypothesized that extracellular cytochrome c could function as an intercellular signaling molecule of the brain, which is recognized by brain microglia. These cells belong to the mononuclear phagocyte system and can be activated by endogenous substances associated with diverse pathologies including trauma, ischemic damage and neurodegenerative diseases...
June 23, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28651603/a-systems-pharmacology-based-approach-to-identify-novel-kv1-3-channel-dependent-mechanisms-in-microglial-activation
#12
Srikant Rangaraju, Syed Ali Raza, Andrea Pennati, Qiudong Deng, Eric B Dammer, Duc Duong, Michael W Pennington, Malu G Tansey, James J Lah, Ranjita Betarbet, Nicholas T Seyfried, Allan I Levey
BACKGROUND: Kv1.3 potassium channels regulate microglial functions and are overexpressed in neuroinflammatory diseases. Kv1.3 blockade may selectively inhibit pro-inflammatory microglia in neurological diseases but the molecular and cellular mechanisms regulated by Kv1.3 channels are poorly defined. METHODS: We performed immunoblotting and flow cytometry to confirm Kv1.3 channel upregulation in lipopolysaccharide (LPS)-activated BV2 microglia and in brain mononuclear phagocytes freshly isolated from LPS-treated mice...
June 26, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28637682/cellular-mechanism-of-fibril-formation-from-serum-amyloid-a1-protein
#13
Stephanie Claus, Katrin Meinhardt, Tobias Aumüller, Ioana Puscalau-Girtu, Julia Linder, Christian Haupt, Paul Walther, Tatiana Syrovets, Thomas Simmet, Marcus Fändrich
Serum amyloid A1 (SAA1) is an apolipoprotein that binds to the high-density lipoprotein (HDL) fraction of the serum and constitutes the fibril precursor protein in systemic AA amyloidosis. We here show that HDL binding blocks fibril formation from soluble SAA1 protein, whereas internalization into mononuclear phagocytes leads to the formation of amyloid. SAA1 aggregation in the cell model disturbs the integrity of vesicular membranes and leads to lysosomal leakage and apoptotic death. The formed amyloid becomes deposited outside the cell where it can seed the fibrillation of extracellular SAA1...
June 21, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28615126/unveiling-the-participation-of-avian-kinin-ornithokinin-and-its-receptors-in-the-chicken-inflammatory-response
#14
Rodrigo Guabiraba, Damien Garrido, Geoffrey Bailleul, Angélina Trotereau, Mélanie Pinaud, Anne-Christine Lalmanach, Nathalie K Chanteloup, Catherine Schouler
Vasoactive peptides are key early mediators of inflammation released through activation of different enzymatic systems. The mammalian kinin-kallikrein (K-KLK) system produces bradykinin (BK) through proteolytic cleavage of a kininogen precursor by enzymes named kallikreins. BK acts through specific ubiquitous G-protein coupled receptors (B1R and B2R) to participate in physiological processes and inflammatory responses, such as activation of mononuclear phagocytes. In chickens, the BK-like nonapeptide ornithokinin (OK) has been shown to promote intracellular calcium increase in embryonic fibroblasts and to be vasodilatory in vivo...
June 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28607366/comparisons-of-the-biodistribution-and-toxicological-examinations-after-repeated-intravenous-administration-of-silver-and-gold-nanoparticles-in-mice
#15
Lin Yang, Huijuan Kuang, Wanyi Zhang, Zoraida P Aguilar, Hua Wei, Hengyi Xu
Nanoparticles (NPs) size, surface functionalization, and concentration were claimed to contribute to distribution and toxicity outcomes of NPs in vivo. However, intrinsic chemical compositions of NPs caused inconsistent biodistribution and toxic profiles which attracted little attention. In this study, silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) were used to determine the biodistribution, toxickinetic, and genotoxicity variances in murine animals. The results demonstrated AgNPs and AuNPs were primarily deposited in the mononuclear phagocyte system (MPS) such as the liver and spleen...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28589972/the-influence-of-tumor-induced-immune-dysfunction-on-the-immune-cell-distribution-of-gold-nanoparticles-in-vivo
#16
Chenxi Wu, Hongmei Chen, Xuan Wu, Xiuxiu Cong, Li Wang, Yucai Wang, Yongguang Yang, Wei Li, Tianmeng Sun
Gold nanoparticles (AuNPs) have been extensively explored as a drug carrier and have been widely used to provide advanced biomedical research tools in diagnostic imaging and therapy for cancer. Although the mononuclear phagocyte system and immune system are known to play the main roles in the clearance of AuNPs during the circulation, the particle distribution within the immune cells under the condition of immune dysfunction caused by tumor growth has not been thoroughly studied. Here, the cellular distribution of Cy5 labeled AuNPs with diameters of 5, 30 and 50 nm is characterized within the immune populations of the blood, spleen and bone marrow from tumor free and tumor bearing mice using flow cytometry...
June 7, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28588573/bovine-wc1-and-wc1-neg-%C3%AE-%C3%AE-t-lymphocytes-influence-monocyte-differentiation-and-monocyte-derived-dendritic-cell-maturation-during-in-vitro-mycobacterium-avium-subspecies-paratuberculosis-infection
#17
Monica M Baquero, Brandon L Plattner
During early Mycobacterium avium subspecies paratuberculosis (Map) infection, complex interactions occur between the bacteria, cells from the mononuclear phagocyte system (MPS) including both resident (macrophages and dendritic cells) and recruited (monocytes) cells, and other mucosal sentinel cells such as γδ T lymphocytes. Though the details of early host-pathogen interactions in cattle remain largely underexplored, our hypothesis is that these significantly influence development of host immunity and ultimate success or failure of the host to respond to Map infection...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28581000/shedding-light-on-zwitterionic-magnetic-nanoparticles-limitations-for-in-vivo-applications
#18
Manuel Pernia Leal, Carlos Caro, María Luisa García-Martín
Over the last few years several studies have dealt with the importance of the surface charge of nanoparticles in prolonging their blood circulation and minimizing their interaction with plasma proteins. These investigations claimed that zwitterionic nanoparticles exhibited a minimal macrophage response and long blood circulation times compared to nanoparticles with other surface charges. These differences in their in vivo behavior are mainly attributed to the interaction of nanoparticles with plasma proteins...
June 5, 2017: Nanoscale
https://www.readbyqxmd.com/read/28577093/structure-of-rat-lungs-after-administration-of-magnetomicelles-based-on-the-carbon-coated-iron-nanoparticles
#19
G Yu Vasyukov, I V Sukhodolo, I V Mil'to, I V Mitrofanova
We studied the effects of single administration of a suspension of magnetomicelles based on carbon-coated iron nanoparticles on the structure of rat lungs within 40 days. Histological analysis revealed a complex of hemodynamic alterations in the lungs. Described changes persisted in the lung stroma from day 1 until day 40, but their intensity decreased by the end of the experiment. Using immunohistochemical Perls reaction we identified cells morphologically corresponding to alveolar and interstitial lung macrophages...
June 2, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28513714/highly-water-stable-rare-ternary-ag-au-se-nanocomposites-as-long-blood-circulation-time-x-ray-computed-tomography-contrast-agents
#20
Carlos Caro, Mariona Dalmases, Albert Figuerola, María Luisa García-Martín, Manuel Pernia Leal
X-ray computed tomography (CT) is a powerful and widely used medical non-invasive technique that often requires intravenous administration of contrast agents (CAs) to better visualize soft tissues. In this work, we have developed a novel CT contrast agent based on ternary Ag-Au-Se chalcogenide nanoparticles (NP). A facile ligand exchange by using a 3 kDa PEGylated ligand with a dithiol dihydrolipoic acid as an anchor group resulted in highly water-soluble and monodisperse nanoparticles. These PEGylated ternary NPs were tested in vivo in mice, showing slow uptake by the mononuclear phagocyte system, long blood circulation times, low toxicity, and very good X-ray contrast, thus being promising candidates as CT contrast agents for clinical applications...
June 1, 2017: Nanoscale
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