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Francesco Antonini-Canterin, Elisa Leiballi, Flavia Martinis, Daniela Pavan
Hypertension is considered the major modifiable risk factor for premature cardiovascular disease, being more common than other important risk factors as cigarette smoking, dyslipidemia, or diabetes [1]. In older patients, systolic pressure and pulse pressure are more powerful determinants of cardiovascular events than diastolic pressure [2]. Importantly, the cardiovascular risk associated with hypertension is significantly affected by the presence or absence of other major risk factors [3]. Among imaging features, left ventricular hypertrophy (LVH) is the more common and early in patients with hypertension [4]...
April 10, 2017: Minerva Cardioangiologica
Marko Novaković, Katja Prokšelj, Vito Starc, Borut Jug
PURPOSE: Adults after surgical repair of tetralogy of Fallot (ToF) may have impaired vascular and cardiac autonomic function. Thus, we wanted to assess interrelations between heart rate variability (HRV) and heart rate recovery (HRR), as parameters of cardiac autonomic function, and arterial stiffness, as a parameter of vascular function, in adults with repaired ToF as compared to healthy controls. METHODS: In a case-control study of adults with repaired ToF and healthy age-matched controls we measured: 5-min HRV variability (with time and frequency domain data collected), carotid artery stiffness (through pulse-wave analysis using echo-tracking ultrasound) and post-exercise HRR (cycle ergometer exercise testing)...
March 8, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
Olga Vriz, Victor Aboyans, Rosalba Minisini, Julien Magne, Nicole Bertin, Mario Pirisi, Eduardo Bossone
Arterial stiffness can predict cardiovascular events, and the aim of this study was to produce age- and sex-specific reference values for echo-tracking carotid stiffness in healthy subjects. A total of 900 subjects (500 males, mean age 45.8±19 years) were enrolled. Common carotid artery stiffness and compliance, using a high-definition echo-tracking ultrasound system, were evaluated. To compare stiffness parameters across the different age groups, individual scores were transformed into T-scores, indicating how many standard deviation (s...
March 2, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Maurizio Cusmà Piccione, Concetta Zito, Bijoy Khandheria, Antonio Madaffari, Alessandra Oteri, Gabriella Falanga, Domenica Donato, Myriam D'Angelo, Maria Ludovica Carerj, Gianluca Di Bella, Egidio Imbalzano, Pietro Pugliatti, Scipione Carerj
BACKGROUND: Impairment of the adaptive mechanisms that increase cardiac output during exercise can translate to a reduced functional capacity. We investigated cardiovascular adaptation to exertion in asymptomatic hypertensive patients, aiming to identify the early signs of cardiac and vascular dysfunction. METHODS AND RESULTS: We enrolled 54 subjects: 30 patients (45.1±11.9years, 19 males) and 24 age-matched healthy controls (44.4±9.6years, 14 males). Speckle-tracking echocardiography (STE) and echo-tracking were performed at rest and during exertion to assess myocardial deformation and arterial stiffness...
January 4, 2017: International Journal of Cardiology
Olga Vriz, Serena Favretto, Joanna Jaroch, Rychard Wojciech, Eduardo Bossone, Caterina Driussi, Francesco Antonini-Canterin, Paolo Palatini, Krystyna Loboz-Grudzien
OBJECTIVES: To investigate whether newly diagnosed untreated hypertensive patients show higher left ventricular (LV) contractility, as assessed by traditional echocardiographic indices and carotid wave intensity (WI) parameters, including amplitude of the peak during early (W1 ) and late systole (W2 ). METHODS: A total of 145 untreated hypertensive patients were compared with 145 age- and sex-matched normotensive subjects. They underwent comprehensive echocardiography and WI analysis...
January 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Olga Vriz, Julien Magne, Caterina Driussi, Gabriele Brosolo, Francesco Ferrara, Paolo Palatini, Victor Aboyans, Eduardo Bossone
Arterial stiffness and compliance parameters from two adjacent elastic arteries [aorta and common carotid artery (CCA)] were compared and their relationship with left ventricular (LV) structure and function and clinical parameters was assessed. 584 healthy subjects were prospectively enrolled [mean age 47.8 ± 18.4 years, range 16-94; 318 (54.4%) men]. They underwent comprehensive transthoracic echocardiography; M-mode diameters were measured at the level of the ascending aorta in systole and diastole and by echo-tracking at the level of the left CCA...
November 24, 2016: International Journal of Cardiovascular Imaging
Telmo Pereira, Armindo Almeida, João Maldonado, Jorge Conde
OBJECTIVE: The Moens-Korteweg equation predicts changes in pulse wave velocity (PWV) following changes in arterial radius, therefore an increase in arterial radius, as seen in a reactive hyperaemia (RH) condition, should slow PWV over a given arterial segment. If this assumption is true, than the deceleration of PWV over the brachial artery (flow-mediated slowing - FMS) should be an equivalent signal of endothelial function during a conventional RH flow-mediated dilation (FMD) procedure...
September 2016: Journal of Hypertension
Telmo Pereira, Armindo Almeida, João Maldonado, Jorge Conde
OBJECTIVE: The Moens-Korteweg equation predicts changes in pulse wave velocity (PWV) following changes in arterial radius, therefore an increase in arterial radius, as seen in a reactive hyperaemia (RH) condition, should slow PWV over a given arterial segment. If this assumption is true, than the deceleration of PWV over the brachial artery (flow-mediated slowing - FMS) should be an equivalent signal of endothelial function during a conventional RH flow-mediated dilation (FMD) procedure...
September 2016: Journal of Hypertension
Joanna Jaroch, Krystyna Łoboz-Grudzień, Stefania Magda, Maria Florescu, Zbigniew Bociąga, Andrea O Ciobanu, Ewa Kruszyńska, Krzysztof Dudek, Dragos Vinereanu
BACKGROUND: Left ventricular hypertrophy (LVH) and geometry patterns vary in different hemodynamic profiles The concentric hypertrophy (CH) pattern has been proved to have the worst prognosis. OBJECTIVES: The aim of the study was to test the hypothesis that carotid artery stiffness, as a marker of vascular damage, is associated with CH, independently of other potential determinants such as demographic factors (age, sex, BMI), clinical parameters (smoking, diabetes, creatinine level) and hemodynamic variables (blood pressure, pulse pressure [PP])...
March 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
S Kiando, N Tucker, L Castro-Vega, D Cusi, P Galan, Empana J-P, J Olin, H Gornik, P-F Plouin, I Kullo, D Milan, S Ganesh, P Boutouyrie, J Kovacic, X Jeunemaitre, N Bouatia-Naji
OBJECTIVE: Fibromuscular dysplasia (FMD) is a nonatherosclerotic vascular disease leading to stenosis, dissection and aneurysm affecting mainly the renal and cerebrovascular arteries. FMD has higher prevalence in females (80-90%) and predisposes to hypertension and stroke but its pathophysiology is unclear. DESIGN AND METHOD: We performed a multistage genetic association study (1,154 patients and 3,895 controls) from five case-control cohorts. We investigated the association between rs9349379 in the phosphatase and actin regulator 1 gene (PHACTR1) and carotid traits by echo-tracking in healthy volunteers, the expression of PHACTR1 by genotypes in human fibroblasts, protein staining pattern in human carotids, and vasculature development after Phactr1 knockdown in zebrafish...
September 2016: Journal of Hypertension
D Skultetyova, S Filipova
OBJECTIVE: The aim of the study is to investigate the relationship between daytime and night-time mean blood pressure (BP) on carotid artery stiffness (CAS) and wave intensity (WI) in 1) hypertensive patients (pts) and in 2) the subgroups formed according to the circadian patterns of BP. DESIGN AND METHOD: We investigated 148 hypertensive pts, mean age 58 years. The subgroups were created according to the circadian patterns (64 dippers, 56 non-dippers, 14 extreme dippers, 14 reverse dippers)...
September 2016: Journal of Hypertension
Alexandra I Ershova, Alexey N Meshkov, Tatyana A Rozhkova, Maria V Kalinina, Alexander D Deev, Anatoliy N Rogoza, Tatyana V Balakhonova, Sergey A Boytsov
BACKGROUND: The role of plasma cholesterol in impairing arterial function and elasticity remains unclear. We evaluated arterial stiffness, measured locally in the common carotid artery by high-resolution echo-tracking, and aortic stiffness, using carotid-femoral pulse wave velocity (PWV) (the "gold-standard" measurement of arterial stiffness), in treatment-naive patients with heterozygous familial hypercholesterolemia (FH). METHODS: The study included 66 patients with FH (10-66 years old) and 57 first-degree relatives without FH (11-61 years old)...
2016: PloS One
George Lindesay, Christophe Ragonnet, Stefano Chimenti, Nicole Villeneuve, Christine Vayssettes-Courchay
Age and hypertension are major causes of large artery remodeling and stiffening, a cardiovascular risk factor for heart and kidney damage. The aged spontaneously hypertensive rat (SHR) model is recognized for human cardiovascular pathology, but discrepancies appeared in studies of arterial stiffness. We performed experiments using a robust analysis via echo tracking in 20-week adult (n = 8) and 80-week-old SHR (n = 7), with age-matched normotensive Wistar Kyoto rats (WKY, n = 6;6) at basal and matched levels of blood pressure (BP)...
May 2016: Physiological Reports
Stéphane Laurent, Louise Marais, Pierre Boutouyrie
The growing interest in the clinical measurement of arterial aging through the noninvasive assessment of arterial stiffness is associated with important developments in novel methods and apparatus. In this review, we aimed to describe the major principles of the measurement of arterial stiffness and to critically review the advantages and limitations of the different methods. The measurement of regional stiffness is recommended by international guidelines for routine clinical practice. It is most often determined through pulse wave velocity (PWV) between 2 arterial sites...
2016: Canadian Journal of Cardiology
H Khettab, B Nayagom, S Millasseau, S Laurent, P Boutouyrie
BACKGROUND: The recognized reference method for endothelial function assessment is brachial artery diameter echo-tracking during flow mediated dilation (FMD) induced by reactive hyperaemia (RH). From the Mons-Korteweg equation, FMD should also reduce upper limb pulse wave velocity (PWV). The aim of our study was to compare echo-tracking FMD with PWV changes after RH. METHODS: Brachial diameter was assessed by echo-tracking (MyLAb 70, Easote, Italy) before and after 7min of ischemia induced by inflating a cuff on the right wirst 50mmHg above subject's systolic blood pressure...
December 2015: Annales de Cardiologie et D'angéiologie
Xavier Melo, Bo Fernhall, Diana A Santos, Rita Pinto, Nuno M Pimenta, Luís B Sardinha, Helena Santa-Clara
This study compared the effects of a bout of maximal running exercise on arterial stiffness in children and adults. Right carotid blood pressure and artery stiffness indices measured by pulse wave velocity (PWV), compliance and distensibility coefficients, stiffness index α and β (echo-tracking), contralateral carotid blood pressure, and upper and lower limb and central/aortic PWV (applanation tonometry) were taken at rest and 10 min after a bout of maximal treadmill running in 34 children (7.38 ± 0.38 years) and 45 young adults (25...
March 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Olga Vriz, Caterina Driussi, Salvatore La Carrubba, Vitantonio Di Bello, Concetta Zito, Scipione Carerj, Francesco Antonini-Canterin
OBJECTIVES: Recently, echo-tracking-derived measures of arterial stiffness have been introduced in clinical practice for the assessment of one-point pulse wave velocity. The purpose of this study was to find a relation between carotid-femoral pulse wave velocity and one-point carotid pulse wave velocity, and to find a value of one-point carotid pulse wave velocity that predicts carotid-femoral pulse wave velocity higher than 12 m/s. METHODS: A total of 160 consecutive subjects (112 male/48 female, mean age = 51...
2013: SAGE Open Medicine
Ravindra B Patil, P Krishnamoorthy, Shriram Sethuraman
Pulse Wave Velocity (PWV) promises to be a useful clinical marker for noninvasive diagnosis of atherosclerosis. This work demonstrates the ability to perform localized carotid PWV measurements from the distention waveform derived from the Radio Frequency (RF) ultrasound signal using a carotid phantom setup. The proposed system consists of low cost custom-built ultrasound probe and algorithms for envelope detection, arterial wall identification, echo tracking, distension waveform computation and PWV estimation...
2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
D Andrade, L Bortolotto, E Bonfá, E Borba
OBJECTIVE: To investigate if patients with Primary Antiphospholipid Syndrome (PAPS) with venous and/or arterial thrombosis without traditional coronary artery disease (CAD) risk factors develop early atherosclerotic vascular damage. METHODS: 27 female patients with PAPS (Sidney criteria) and 27 age, body mass index (BMI), and sex matched controls were consecutively selected. Exclusion criteria were: black race, age ≥55 years, traditional cardiovascular risk factors, other thrombophilias or connective tissue diseases, corticosteroids use and pregnancy...
April 2016: Lupus
Jelle Bossuyt, Lian Engelen, Isabel Ferreira, Coen D Stehouwer, Pierre Boutouyrie, Stéphane Laurent, Patrick Segers, Koen Reesink, Luc M Van Bortel
OBJECTIVE: Carotid-femoral pulse wave velocity (PWV) is considered the gold standard measure of arterial stiffness, representing mainly aortic stiffness. As compared with the elastic carotid and aorta, the more muscular femoral artery may be differently associated with cardiovascular risk factors (CV-RFs), or, as shown in a recent study, provide additional predictive information beyond carotid-femoral PWV. Still, clinical application is hampered by the absence of reference values. Therefore, our aim was to establish age and sex-specific reference values for femoral stiffness in healthy individuals and to investigate the associations with CV-RFs...
October 2015: Journal of Hypertension
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