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Piperacillin-tazobactam

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https://www.readbyqxmd.com/read/29679648/in-vitro-activity-of-tigecycline-and-comparators-against-a-european-collection-of-anaerobes-collected-as-part-of-the-tigecycline-evaluation-and-surveillance-trial-t-e-s-t-2010-2016
#1
Arne C Rodloff, Michael J Dowzicky
The Tigecycline Evaluation and Surveillance Trial (T.E.S.T.) is a global program that aims to monitor the in vitro antimicrobial activities of current therapeutic agents against clinical isolates. This study presents surveillance data for Gram-positive and Gram-negative anaerobic isolates (N = 7008) collected from nine European countries between 2010 and 2016. Presented in this study are antimicrobial susceptibility data, according to the European Committee for Antimicrobial Susceptibility Testing (EUCAST) breakpoints, and minimum inhibitory concentration (MIC) distributions...
April 18, 2018: Anaerobe
https://www.readbyqxmd.com/read/29678565/simplification-of-first-line-antibacterial-regimen-for-complicated-appendicitis-in-children-was-associated-with-better-adherence-to-guidelines-and-reduced-use-of-antibiotics
#2
Marion Taleb, Nicolas Nardi, Alexis Arnaud, Nathalie Costet, Pierre-Yves Donnio, Charlotte Engrand, Edouard Habonimana, Eric Wodey, Pierre Tattevin
Acute appendicitis in children requires early surgery, and a short course of antibiotics active on Enterobacteriaceae and anaerobes. Although aminoglycoside-containing 3-drug regimen have been used successfully for decades, simpler regimens with similar efficacy are increasingly used. We aimed to evaluate the impact of a switch from the combination of cefotaxime, metronidazole, and gentamicin (regimen 1), to piperacillin-tazobactam (regimen 2), as first-line regimen for complicated acute appendicitis in children...
April 17, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29678480/gram-negative-anaerobe-susceptibility-testing-in-clinical-isolates-using-sensititre-and-etest-methods
#3
C Hughes, C Ashhurst-Smith, J K Ferguson
Gram negative anaerobic organisms are important pathogens in a range of clinical infections, and susceptibility testing is not commonly performed in the microbiology laboratory. We performed anaerobic susceptibility testing on 70 clinically relevant Gram negative anaerobes isolated from routine cultures in a busy diagnostic laboratory which were identified by MALDI-TOF mass spectrometry (MALDI-TOF MS). The susceptibility testing was performed by two methods: Sensititre trays (ThermoFisher Scientific) against 15 different antibiotics, and Etests (bioMérieux) against five clinically relevant antibiotics (metronidazole, piperacillin-tazobactam, amoxicillin-clavulanate, meropenem and clindamycin)...
April 17, 2018: Pathology
https://www.readbyqxmd.com/read/29675787/meropenem-vaborbactam-a-carbapenem-and-beta-lactamase-inhibitor-with-activity-against-carbapenem-resistant-enterobacteriaceae
#4
REVIEW
Young R Lee, Nathaniel T Baker
Meropenem-vaborbactam is a carbapenem and β-lactamase inhibitor combination that is newly indicated for the treatment of complicated urinary tract infections (cUTI), including adult pyelonephritis. Vaborbactam was developed due to emergence of carbapenem-resistant strains of Enterobacteriaceae. In a phase I trial, patients that received meropenem-vaborbactam 2-2 g intravenously over 3 h every 8 h, Cmax was 58.2 ± 10.8 μg/mL for meropenem and 59.0 ± 8.4 μg/mL for vaborbactam. AUC0-8 was 186 ± 33...
April 19, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29670781/-candida-krusei-empyema-thoracis-a-community-acquired-infection-requiring-a-high-index-of-suspicion
#5
Hazim Bukamur, Waseem Ahmed, Yazan Numan, Ibrahim Shahoub, Fuad Zeid
Empyema thoracis is a serious condition characterized by the accumulation of purulent fluid in the pleural cavity, typically following a pneumonia, subdiaphragmatic abscess, or esophageal rupture. Fungal empyema thoracis is a rare form of this condition with especially high mortality, in which the most frequently isolated fungus is Candida spp. This article presents a 74-year-old female with Candida krusei pneumonia and a complicated hospital course, initially presenting with nausea, vomiting, and dysphagia...
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29662672/results-of-a-local-combination-therapy-antibiogram-for-pseudomonas-aeruginosa-isolates-is-double-worth-the-trouble
#6
Matthew Song, Thomas J Dilworth, Erik Munson, Jim Davis, Ramy H Elshaboury
Purpose: To determine the frequency at which fluoroquinolones and aminoglycosides demonstrate in vitro activity against non-urinary, non-skin/skin structure Pseudomonas aeruginosa isolates exhibiting decreased susceptibilities to one or more β-lactam agents. Methods: β-lactam-non-susceptible P. aeruginosa isolates recovered from blood, bone, lower respiratory tract, pleural fluid, cerebrospinal fluid, or peritoneal fluid cultures between October 2010 and October 2014 were reviewed from four community hospitals within a single health-system...
November 2017: Therapeutic Advances in Infectious Disease
https://www.readbyqxmd.com/read/29651861/the-first-characterized-carbapenem-resistant-bacteroides-fragilis-strain-from-croatia-and-the-case-study-for-it
#7
Maja Bogdan, Ljilijana Perić, Katalin Ördög, Dubravka Vuković, Edit Urbán, József Sóki
An imipenem-resistant Bacteroides fragilis strain was isolated from the blood of a 72-year-old male patient with a urinary bladder tumor in Osijek, Croatia. This strain was also resistant to ampicillin, piperacillin/tazobactam, cefoxitin, clindamycin, tetracycline, and harbored cfiA, ermF, and tetQ genes where the high-level expression of the cfiA carbapenem-resistant gene was driven by an IS1187 element. Interestingly, despite the carbapenem-resistant feature of the B. fragilis from blood, the patient relatively easily recovered from the bacteremia...
April 13, 2018: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/29649850/-diagnostic-and-treatment-strategies-in-morel-lavallee-lesions-in-the-spinal-column-and-pelvis
#8
Christopher A Becker, Christian Kammerlander, Axel Greiner, Fabian Sommer, Christoph Linhart, Wolfgang Böcker, Bianka Rubenbauer, Simon Weidert
BACKGROUND: The Morel-Lavallée lesion is one of the concomitant soft tissue lesions of pelvic fractures. Its role in spine fractures and its treatment in combination with osteosynthesis of pelvic or spine fractures have not yet been determined. The aim of this study was to analyse the best diagnostic and treatment options of both spine and pelvic fractures combined with Morel-Lavallée lesions (MLL). METHODS: An analysis of the literature was performed via PubMed and Medline...
April 12, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29649586/nephrotoxicity-of-piperacillin-tazobactam-combined-with-vancomycin-should-it-be-a-concern
#9
Cafer Balcı, Ömrüm Uzun, Mustafa Arıcı, Sibel Aşçıoğlu Hayran, Deniz Yüce, Serhat Ünal
The combination of piperacillin-tazobactam (pip-tazo) and vancomycin provides a wide spectrum of activity against many pathogens acquired in the health-care setting. However, there have been reports of increased potential for nephrotoxicity with this combination. The aim of this study was to evaluate the nephrotoxic effect of pip-tazo plus vancomycin and compare it with that of pip-tazo and vancomycin alone, and meropenem plus vancomycin, another broad-spectrum combination. A total of 402 patients receiving either antimicrobial regimen for more than 48 hours were evaluated retrospectively in a two-year period...
April 9, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29626676/current-epidemiology-genetic-evolution-and-clinical-impact-of-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-and-klebsiella-pneumoniae
#10
REVIEW
Yong Chong, Shinji Shimoda, Nobuyuki Shimono
The worldwide spread of extended-spectrum β-lactamase (ESBL)-producing bacteria, particularly Escherichia coli and Klebsiella pneumoniae, is a critical concern for the development of therapies against multidrug-resistant bacteria. Since the 2000s, detection rates of CTX-M types ESBL-producing E. coli in the community have been high, possibly contributing to their nosocomial detection. Various factors, such as environmental sources, food animals, and international travel, accelerate the global ESBL spread in the community...
April 4, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29626525/whole-genome-sequence-of-an-mcr-1-carrying-esbl-producing-escherichia-coli-st746-isolate-recovered-from-community-acquired-urinary-tract-infection
#11
Lingjiao Wu, Jing Chen, Li Wang, Zhe Wu
OBJECTIVES: Colistin is regarded as one of the last-resort antimicrobials for severe infections. Plasmid-borne mobile colistin resistance gene (mcr-1)-carrying isolates were rarely reported in community-acquired infections. Here we report the draft genome sequence of an MCR-1-carrying, extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolate from community-acquired urinary tract infection. MTHODS: Antimicrobial susceptibility tests (AST) were determined by the broth microdilution method...
April 4, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29624028/uncommon-occurrence-of-high-piperacillin-tazobactam-and-meropenem-plasma-concentrations-and-concomitant-absence-of-neurotoxicity-in-pediatrics
#12
Alessio Mesini, Anna Loy, Giuseppe Losurdo, Cristina Moroni, Sebastiano Barco, Giuliana Cangemi, Andrea Moscatelli, Francesco Risso, Elio Castagnola
No abstract text is available yet for this article.
April 5, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29616156/a-case-of-postpartum-ovarian-vein-thrombosis
#13
Sidra Khalid, Aariez Khalid, Hamed Daw
Ovarian vein thrombosis (OVT) is an rare condition, which can present in the postpartum period. We present a case of a 35-year-old female who presented with right lower quadrant pain and fever. Her computed tomography (CT) abdomen revealed a dilated right ovarian vein with soft tissue attenuation material in its lumen that extended into the inferior vena cava, along with fat stranding of the surrounding soft tissues signifying thrombophlebitis. She was treated with enoxaparin and piperacillin-tazobactam, which lead to a resolution of the thrombus...
February 1, 2018: Curēus
https://www.readbyqxmd.com/read/29615167/pseudomonas-aeruginosa-evaluation-of-pathogen-burden-and-drug-resistance-trends-in-a-tertiary-care-hospital
#14
Muhammad Saeed, Farhan Rasheed, Raja Kamran Afzal, Shahida Hussain, Saba Riaz, Adeel Ahmad
OBJECTIVE: To evaluate the pathogen burden and antibiotic-resistance trends of Pseudomonas aeruginosa among hospitalised patients at a tertiary care hospital. STUDY DESIGN: Retrospective, hospital record-based, cross-sectional study. PLACE AND DURATION OF STUDY: Microbiology Laboratory, Allama Iqbal Medical College/Jinnah Hospital, Lahore, from January 2014 to December 2016. METHODOLOGY: A total of 5,960 samples were collected from clinically suspected cases of bacterial infections, admitted to the hospital...
April 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29608958/point-prevalence-surveys-of-antimicrobial-use-among-eight-neonatal-intensive
#15
Sumanth Gandra, Gerardo Alvarez-Uria, Srinivas Murki, Sanjeev K Singh, Ravishankar Kanithi, Dasaratha R Jinka, Ashok K Chikkappa, Sreeram Subramanian, Anita Sharma, Dhanya Dharmapalan, Hemasree Kandraju, Anil Kumar Vasudevan, Onkaraiah Tunga, Akhila Akula, Yingfen Hsia, Mike Sharland, Ramanan Laxminarayan
BACKGROUND: Information about antimicrobial use is scarce and poorly understood among neonatal intensive care units (NICUs) in India. In this study, we describe antimicrobial use in eight NICUs using four point prevalence surveys (PPSs). METHODS: As part of the Global Antimicrobial Resistance, Prescribing, and Efficacy in Neonates and Children (GARPEC) study, one-day, cross-sectional, hospital-based PPSs were conducted four times between 1 February 2016 and 28 February 2017 in eight NICUs...
March 30, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29608680/extended-versus-bolus-infusion-of-broad-spectrum-%C3%AE-lactams-for-febrile-neutropenia-an-unblinded-randomized-trial
#16
Ron Ram, Yael Halavy, Odelia Amit, Yael Paran, Eugene Katchman, Bruria Yachini, Svetlana Kor, Irit Avivi, Ronen Ben-Ami
Background: Febrile neutropenia may be a sign of severe infection, and is associated with significant morbidity and mortality in high-risk patients with hematologic malignancies. Extended infusion of β-lactam antibiotics is associated with greater clinical response than is bolus infusion in non-neutropenic critically ill patients, but data are lacking for febrile neutropenic patients. Methods: We designed a single-center, non-blinded randomized trial comparing extended infusion (4 hours) and bolus infusion (30 minutes) of piperacillin-tazobactam or ceftazidime in high-risk patients with febrile neutropenia...
March 28, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29606259/-vancomycin-nephrotoxicity-frequency-and-mechanistic-aspects
#17
Yosu Luque, Laurent Mesnard
Vancomycin, discovered in 1953 and widely used today, has a nephrotoxic potential that has long been debated. The frequency of renal involvement is variable and can range from 5% to 30% depending concomitant risk factors: overdose, chronic kidney disease, obesity, hypovolemia, and use of other nephrotoxic drugs as aminoglycosides. Its association with piperacillin-tazobactam also appears to increase the risk of nephrotoxicity. This hypothesis should be confirmed experimentally. Vancomycin-induced oxidative stress in tubular cells and intraluminal cast formation are the two physiopathological mechanisms explaining its nephrotoxicity...
April 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29596815/therapeutic-drug-monitoring-of-piperacillin-and-tazobactam-by-rp-hplc-of-residual-blood-specimens
#18
Sylvia M Verhoven, Joseph J Groszek, William H Fissell, Adam Seegmiller, Jennifer Colby, Pratish Patel, Alain Verstraete, Matthew Shotwell
BACKGROUND: Sepsis is a common diagnosis in critical care with inpatient mortality rates up to 50%. Sepsis care is organized around source control, antibiotics, and supportive care. Drug disposition is deranged by changes in volume of distribution and regional blood flow, as well as multiple organ failure. Thus, assuring that each patient with sepsis attains pharmacokinetic targets is challenging. There is currently no commercially available FDA-approved assay to measure piperacillin-tazobactam, very commonly used as a beta-lactam/beta-lactamase inhibitor combination antibiotic in the intensive care unit (ICU)...
March 26, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29592767/drug-shortages-in-a-pediatric-stem-cell-transplantation-ward-challenges-and-implications-a-5-year-bilan
#19
B Claus, T Bauters, G Laureys
This article describes the implications of shortages of pharmaceutical products used in conditioning and supportive care regimens of pediatric patients undergoing a hematopoietic stem cell transplantation in a tertiary care hospital. Between July 2011 and July 2016, a total of 84 individual shortages, affecting 22 different drugs (79.8% supportive care drugs; 20.2% chemotherapeutics) were detected with a mean duration of 85 days (SD 138) per individual drug shortage. Eighteen shortages were critical and very urgent...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29590376/incidence-of-nephrotoxicity-among-pediatric-patients-receiving-vancomycin-with-either-piperacillin-tazobactam-or-cefepime-a-cohort-study
#20
Kathryn M Cook, Jessica Gillon, Alison G Grisso, Ritu Banerjee, Natalia Jimenez-Truque, Elizabeth J Phillips, Sara L Van Driest
Background: Recent studies in adults have found an incidence of acute kidney injury (AKI) in patients treated with a combination of vancomycin and piperacillin-tazobactam (TZP) that is greater than that expected with either medication alone. The purpose of this study was to determine whether combination therapy with vancomycin and TZP is associated with an incidence of AKI in pediatric patients higher than that in those on combination therapy with vancomycin and cefepime. Methods: We performed a retrospective single-center matched-cohort study of pediatric patients who received vancomycin in combination with TZP or cefepime between January 2015 and June 2016...
March 26, 2018: Journal of the Pediatric Infectious Diseases Society
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