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https://www.readbyqxmd.com/read/27924871/prognostic-implications-of-aspiration-pneumonia-in-patients-with-community-acquired-pneumonia-a-systematic-review-with-meta-analysis
#1
Kosaku Komiya, Bruce K Rubin, Jun-Ichi Kadota, Hiroshi Mukae, Tomohiro Akaba, Hiroshi Moro, Nobumasa Aoki, Hiroki Tsukada, Shingo Noguchi, Nobuaki Shime, Osamu Takahashi, Shigeru Kohno
: Aspiration pneumonia is thought to be associated with a poor outcome in patients with community acquired pneumonia (CAP). However, there has been no systematic review regarding the impact of aspiration pneumonia on the outcomes in patients with CAP. This review was conducted using the MOOSE guidelines: Patients: patients defined CAP. EXPOSURE: aspiration pneumonia defined as pneumonia in patients who have aspiration risk. Comparison: confirmed pneumonia in patients who were not considered to be at high risk for oral aspiration...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27923446/obesity-is-more-closely-related-with-hepatic-steatosis-and-fibrosis-measured-by-transient-elastography-than-metabolic-health-status
#2
Ji Hye Huh, Kwang Joon Kim, Seung Up Kim, Seung Hwan Han, Kwang-Hyub Han, Bong-Soo Cha, Choon Hee Chung, Byung-Wan Lee
OBJECTIVE: The pathogenesis of non-alcoholic fatty liver disease (NAFLD) involves multiple concomitant events induced by obesity and metabolic health condition. This study aimed to assess the risk of NAFLD according to metabolic health and obesity status using transient elastography (TE). MATERIALS AND METHODS: A total of 2198 asymptomatic adults without chronic liver disease and who underwent a medical health check-up were recruited. Subjects were categorized into four groups according to metabolic health and obesity statuses: metabolically healthy non-obese (MHNO); metabolically unhealthy non-obese (MUNO); metabolically healthy obese (MHO); and metabolically unhealthy obese (MUO)...
January 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27922522/chronic-kidney-disease-predicts-coronary-plaque-vulnerability-an-optical-coherence-tomography-study
#3
Jiannan Dai, Lei Xing, Jingbo Hou, Haibo Jia, Sining Hu, Jinwei Tian, Lin Lin, Lulu Li, Yinchun Zhu, Gonghui Zheng, Shaosong Zhang, Bo Yu, Ik-Kyung Jang
OBJECTIVE: The addition of cystatin C to creatinine in calculating the estimated glomerular filtration rate (eGFR) is known to improve the risk prediction for cardiovascular events. We sought to investigate the associations between eGFRs calculated by three Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations and coronary plaque phenotype by optical coherence tomography. PATIENTS AND METHODS: We analyzed 181 nonculprit plaques from 116 coronary artery disease patients...
December 2, 2016: Coronary Artery Disease
https://www.readbyqxmd.com/read/27921227/-nosocomial-pneumonia-from-a%C3%A2-radiological-perspective
#4
REVIEW
P Agarwal, A Wielandner
Due to the high morbidity and mortality, nosocomial pneumonia represents a serious risk in hospitalized patients. The increased risk of infections with multidrug-resistant (MDR) pathogens makes a timely diagnosis and prompt therapy indispensable. A newly occurring or progressive infiltrate in any patient who has been hospitalized for more than 48 h should be viewed with suspicion. In contrast to community acquired pneumonia (CAP), radiography plays a limited role in the diagnosis of hospital-acquired pneumonia (HAP)...
December 5, 2016: Der Radiologe
https://www.readbyqxmd.com/read/27915586/rosuvastatin-prevents-aortic-arch-plaque-progression-and-improves-prognosis-in-ischemic-stroke-patients
#5
Kazuyoshi Kaneko, Hiroki Saito, Toshiki Sasaki, Shigeo Sugawara, Masahiro Akasaka, Tohru Kanaya, Isao Kubota
OBJECTIVES: Complicated aortic arch plaques (CAP) and their progression are important for recurrent ischemic stroke (IS) and its prognosis. We investigated the effects and clinical benefits of rosuvastatin therapy on this pathophysiology. The purpose of this study was to investigate whether rosuvastatin prevention of aortic arch plaque progression improved the prognosis of IS patients. METHODS: Ninety-seven consecutive acute cerebral embolism patients were retrospectively surveyed...
December 5, 2016: Neurological Research
https://www.readbyqxmd.com/read/27914135/is-%C3%AE-lactam-plus-macrolide-more-effective-than-%C3%AE-lactam-plus-fluoroquinolone-among-patients-with-severe-community-acquired-pneumonia-a-systemic-review-and-meta-analysis
#6
Jong Hoo Lee, Hyun Jung Kim, Yee Hyung Kim
Adding either macrolide or fluoroquinolone (FQ) to β-lactam has been recommended for patients with severe community-acquired pneumonia (CAP). However, due to the limited evidence available, there is a question as to the superiority of the two combination therapies. The MEDLINE, EMBASE, Cochrane Central Register, Scopus, and Web of Science databases were searched for systematic review and meta-analysis. A total of eight trials were analyzed. The total number of patients in the β-lactam plus macrolide (BL-M) and β-lactam plus fluoroquinolone (BL-F) groups was 2,273 and 1,600, respectively...
January 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27911103/tools-for-outcome-prediction-in-patients-with-community-acquired-pneumonia
#7
Faheem Khan, Mark B Owens, Marcos Restrepo, Pedro Povoa, Ignacio Martin-Loeches
Community-acquired pneumonia (CAP) is one of the most common causes of mortality world-wide. The mortality rate of patients with CAP is influenced by the severity of the disease, treatment failure and the requirement for hospitalization and/or intensive care unit (ICU) management, all of which may be predicted by biomarkers and clinical scoring systems. Areas Covered: We review the recent literature examining the efficacy of established and newly-developed clinical scores, biological and inflammatory markers such as C-Reactive protein (CRP), procalcitonin (PCT) and Interleukin-6 (IL-6), whether used alone or in conjunction with clinical severity scores to assess the severity of CAP, predict treatment failure, guide acute in-hospital or ICU admission and predict mortality...
December 2, 2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/27905699/green-light-vaporization-of-the-prostate-pvp-is-it-an-adult-technique
#8
Aldo Brassetti, Cosimo De Nunzio, Nicolas Barry Delongchamps, Cristian Fiori, Francesco Porpiglia, Andrea Tubaro
INTRODUCTION: Intending to overcome Transurethral resection of the prostate (TURP) in terms of safety maintaining its efficacy profile, have led to the introduction of minimally invasive laser therapies to treat men with lower urinary tract symptoms (LUTS) secondary to Benign prostatic obstruction (BPO), each one with its unique properties. Aim of this review was to analyse and summarize all the existing data regarding the 180 W Xcelerated Performance System (XPS) Potoselective Vaporization of the Prostate (PVP)...
December 1, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27904523/the-role-of-near-infrared-spectroscopy-in-the-detection-of-vulnerable-atherosclerotic-plaques
#9
Martin Horvath, Petr Hajek, Cyril Stechovsky, Jakub Honek, Miloslav Spacek, Josef Veselka
Coronary artery disease is the leading cause of mortality worldwide. Most acute coronary syndromes are caused by a rupture of a vulnerable atherosclerotic plaque which can be characterized by a lipid-rich necrotic core with an overlying thin fibrous cap. Many vulnerable plaques can cause angiographically mild stenoses due to positive remodelling, which is why the extent of coronary artery disease may be seriously underestimated. In recent years, we have witnessed a paradigm shift in interventional cardiology...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27903121/craniopharyngioma-adherence-a-comprehensive-topographical-categorization-and-outcome-related-risk-stratification-model-based-on-the-methodical-examination-of-500-tumors
#10
Ruth Prieto, José María Pascual, Maria Rosdolsky, Inés Castro-Dufourny, Rodrigo Carrasco, Sewan Strauss, Laura Barrios
OBJECTIVE Craniopharyngioma (CP) adherence strongly influences the potential for achieving a radical and safe surgical treatment. However, this factor remains poorly addressed in the scientific literature. This study provides a rational, comprehensive description of CP adherence that can be used for the prediction of surgical risks associated with the removal of these challenging lesions. METHODS This study retrospectively analyzes the evidence provided in pathological, neuroradiological, and surgical CP reports concerning 3 components of the CP attachment: 1) the intracranial structures attached to the tumor; 2) the morphology of the adhesion; and 3) the adhesion strength...
December 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27900407/do-inhibitors-of-crystallisation-play-any-role-in-the-prevention-of-kidney-stones-a-critique
#11
REVIEW
William G Robertson
A critical examination of data in the literature and in as yet unpublished laboratory records on the possible role of so-called inhibitors of crystallisation in preventing the formation of calcium-containing kidney stones leads to the following conclusions. So-called inhibitors of spontaneous "self-nucleation" are unlikely to play any role in the initiation of the crystallisation of CaOx or CaP in urine because excessive urinary supersaturation of urine with respect to these salts dominates the onset of "self-nucleation" within the normal time frame of the transit of tubular fluid through the nephron (3-4 min)...
November 29, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27895035/microrna-210-enhances-fibrous-cap-stability-in-advanced-atherosclerotic-lesions
#12
Suzanne M Eken, Hong Jin, Ekaterina Chernogubova, Yuhuang Li, Nancy Simon, Changyan Sun, Greg Korzunowicz, Albert Busch, Alexandra Bäcklund, Cecilia Österholm, Anton Razuvaev, Thomas Renné, Hans-Henning Eckstein, Jaroslav Pelisek, Per Eriksson, Maria Gonzalez Diez, Ljubica P Matic Perisic, Isabel N Schellinger, Uwe Raaz, Nicholas J Leeper, Göran K Hansson, Gabrielle Paulsson-Berne, Ulf Hedin, Lars Maegdefessel
RATIONALE: In the search for markers and modulators of vascular disease, miRNAs have emerged as potent therapeutic targets. OBJECTIVE: To investigate miRNAs of clinical interest in patients with unstable carotid stenosis at risk of stroke. METHODS AND RESULTS: Utilizing patient material from the Biobank of Karolinska Endarterectomies (BiKE), we profiled miRNA expression in patients with stable vs unstable carotid plaque. A PCR-based miRNA array of plasma, sampled at the carotid lesion site, identified eight deregulated miRNAs (miR-15b, -29c, -30c/d, -150, -191, -210 and -500)...
November 28, 2016: Circulation Research
https://www.readbyqxmd.com/read/27894805/leaching-behavior-of-veterinary-antibiotics-in-animal-manure-applied-soils
#13
Min Pan, L M Chu
Agricultural fields worldwide are being contaminated by the escalating application of veterinary antibiotics (VAs) via animal manure and biosolids applied as fertilizers or of wastewater for irrigation, resulting in soil degradation and damage to the health of terrestrial environments. This paper describes a series of column studies investigating the leaching behavior of five VAs, tetracycline (TC), sulfamethazine (SMZ), norfloxacin (NOR), erythromycin (ERY) and chloramphenicol (CAP), under different simulated rainfall conditions that could occur in agricultural environments...
November 25, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27893402/a-convolutional-neural-network-for-automatic-characterization-of-plaque-composition-in-carotid-ultrasound
#14
Karim Lekadir, Alfiia Galimzianova, Angels Betriu, Maria Del Mar Vila, Laura Igual, Daniel Rubin, Elvira Fernandez, Petia Radeva, Sandy Napel
Characterization of carotid plaque composition, more specifically the amount of lipid core, fibrous tissue, and calcified tissue, is an important task for the identification of plaques that are prone to rupture, and thus for early risk estima-tion of cardiovascular and cerebrovascular events. Due to its low costs and wide availability, carotid ultrasound has the potential to become the modality of choice for plaque characterization in clinical practice. However, its significant image noise, coupled with the small size of the plaques and their complex appearance, makes it difficult for automated techniques to discriminate be-tween the different plaque constituents...
November 22, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/27888989/burden-and-risk-factors-of-ambulatory-or-hospitalized-cap-a%C3%A2-population-based-cohort-study
#15
Martin Kolditz, Falko Tesch, Luise Mocke, Gert Höffken, Santiago Ewig, Jochen Schmitt
BACKGROUND: Data on incidence, risk factors and outcome of community-acquired pneumonia (CAP) including outpatients is sparse. METHODS: We conducted a cohort study on 1.837.080 adults insured by a German statutory health insurance in 2010-2011. CAP was identified via ICD-10-GM codes, ambulatory cases were validated by antibiotic prescription within 7 days. Primary outcomes were incidence, hospitalisation and 30-day all-cause mortality. Evaluated risk factors included age, sex and comorbidities...
December 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27887037/failure-of-crp-decline-within-three-days-of-hospitalization-is-associated-with-poor-prognosis-of-community-acquired-pneumonia
#16
Stine Bang Andersen, Gertrud Baunbæk Egelund, Andreas Vestergaard Jensen, Pelle Trier Petersen, Gernot Rohde, Pernille Ravn
BACKGROUND: C-reactive protein (CRP) is a well-known acute phase protein used to monitor the patient's response during treatment in infectious diseases. Mortality from Community-acquired Pneumonia (CAP) remains high, particularly in hospitalized patients. Better risk prediction during hospitalization could improve management and ultimately reduce mortality levels. The aim of this study was to evaluate CRP on the 3rd day (CRP3) of hospitalization as a predictor for 30 days mortality. METHODS: A retrospective multicentre cohort study of adult patients admitted with CAP at three Danish hospitals...
November 25, 2016: Infectious Diseases
https://www.readbyqxmd.com/read/27884085/the-roles-of-myeloperoxidase-in-coronary-artery-disease-and-its-potential-implication-in-plaque-rupture
#17
Nathaniel Teng, Ghassan J Maghzal, Jihan Talib, Imran Rashid, Antony K Lau, Roland Stocker
Atherosclerosis is the main pathophysiological process underlying coronary artery disease (CAD). Acute complications of atherosclerosis, such as myocardial infarction, are caused by the rupture of vulnerable atherosclerotic plaques, which are characterized by thin, highly inflamed, and collagen-poor fibrous caps. Several lines of evidence mechanistically link the heme peroxidase myeloperoxidase (MPO), inflammation as well as acute and chronic manifestations of atherosclerosis. MPO and MPO-derived oxidants have been shown to contribute to the formation of foam cells, endothelial dysfunction and apoptosis, the activation of latent matrix metalloproteinases, and the expression of tissue factor that can promote the development of vulnerable plaque...
November 25, 2016: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/27867552/prognostic-value-of-on-admission-arterial-pco2-in-hospitalized-patients-with-community-acquired-pneumonia
#18
Zeynab Yassin, Mohammad Saadat, Hamidreza Abtahi, Abbas Rahimi Foroushani, Soheil Peiman
BACKGROUND: There is little data about the correlation between the outcome of community acquired pneumonia (CAP) and the hypercapnic type respiratory failure. In this study we prospectively investigated the prognostic significance of first arterial CO2 tension in patients hospitalized with CAP. METHODS: In this prospective study patients with CAP, admitted to a general hospital were included. PaCO2 was measured for each subject in an arterial blood sample drawn in the first 2 hours and its correlations with three major outcomes were evaluated: intensive care unit (ICU) admission, duration of admission and mortality in 30 days...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27865698/immunohistochemical-analysis-of-debris-captured-by-filter-type-distal-embolic-protection-devices-for-carotid-artery-stenting
#19
Yukinao Kambayashi, Ichiro Yuki, Toshihiro Ishibashi, Ayako Ikemura, Takashi Umezawa, Masafumi Suzuki, Issei Kan, Hiroyuki Takao, Yuichi Murayama
BACKGROUND: Little is known about the micro-debris captured in filter-type distal embolic protection devices (EPD) used for carotid stenting (CAS). This study aimed to determine the histological and immunohistochemical characteristics of such debris by using a new liquid-based cytology (LBC) technique. METHODS: Fifteen patients who underwent CAS using a filter-type distal EPD (FilterWire EZ; Boston Scientific, Marlborough, MA, USA) were included in the study. After gross inspection of each recovered filter device, micro-debris were collected using a new LBC technique (SurePath; TriPath Imaging, Inc...
November 17, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27862285/does-travel-time-to-a-radiation-facility-impact-patient-decision-making-regarding-treatment-for-prostate-cancer-a-study-of-the-new-hampshire-state-cancer-registry
#20
Fady Ghali, Maria Celaya, Michael Laviolette, Johann Ingimarsson, Heather Carlos, Judy Rees, Elias Hyams
PURPOSE: We sought to determine whether further distance from a radiation center is associated with lower utilization of external beam radiation therapy (XRT). METHODS: We retrospectively identified patients with a new diagnosis of localized prostate cancer (CaP) within the New Hampshire State Cancer Registry from 2004 to 2011. Patients were categorized by age, D'Amico risk category, year of treatment, marital status, season of diagnosis, urban/rural residence, and driving time to the nearest radiation facility...
November 11, 2016: Journal of Rural Health
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