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https://www.readbyqxmd.com/read/29763667/selection-of-a-round-convex-tablet-shape-that-mitigates-the-risk-of-chipping-and-capping-based-on-systematic-evaluation-by-utilizing-multivariate-analysis
#1
Shuichi Tanabe, Hiroshi Nakagawa, Tomoyuki Watanabe, Hidemi Minami, Shuichi Ando, Nora A Urbanetz, Regina Scherließ
Selecting a tablet shape that minimizes the risk of chipping and capping during manufacture is important in pharmaceutical industry. Here, the selection was performed based on systematic evaluation for the first time. Abrasion and stress relaxation time were utilized as indices of the occurrences of chipping and capping, respectively. Partial least square regression models that used tablet shape parameters to estimate the tablet's abrasion and stress relaxation time were utilized to develop response surface plots of the effect of the tablet shapes on the occurrence of chipping and capping systematically, and to identify an optimum tablet shape that is expected to have a low occurrence of chipping and capping...
May 12, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29762338/incidence-and-risk-factors-for-instrumentation-related-complications-after-scoliosis-surgery-in-pediatric-patients-with-nf-1
#2
Ziming Yao, Hao Li, Xuejun Zhang, Chengxin Li, Xinyu Qi
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To assess the incidence and risk factors of instrumentation-related complication (IRC) in pediatric patients surgically treated for neurofibromatosis type 1 (NF-1) dystrophic scoliosis. SUMMARY OF BACKGROUND DATA: Surgical management including growing rods technique and early definitive fusion has been recommended to avoid progression of NF-1 scoliosis. However, no study has yet investigated the incidence and risk factors of IRC in these surgical interventions...
May 14, 2018: Spine
https://www.readbyqxmd.com/read/29758428/threats-to-coastal-communities-of-mahanadi-delta-due-to-imminent-consequences-of-erosion-present-and-near-future
#3
Anirban Mukhopadhyay, Pramit Ghosh, Abhra Chanda, Amit Ghosh, Subhajit Ghosh, Shouvik Das, Tuhin Ghosh, Sugata Hazra
Coastal erosion is a natural hazard which causes significant loss to properties as well as coastal habitats. Coastal districts of Mahanadi delta, one of the most populated deltas of the Indian subcontinent, are suffering from the ill effects of coastal erosion. An important amount of assets is being lost every year along with forced migration of huge portions of coastal communities due to erosion. An attempt has been made in this study to predict the future coastline of the Mahanadi Delta based on historical trends...
May 11, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29753254/posttraumatic-stress-disorder-depression-and-suicidal-ideation-in-veterans-results-from-the-mind-your-heart-study
#4
Melanie B Arenson, Mary A Whooley, Thomas C Neylan, Shira Maguen, Thomas J Metzler, Beth E Cohen
Veterans with PTSD or depression are at increased risk for suicidal ideation. However, few studies have examined that risk in those with comorbid PTSD and depression, instead focusing on these disorders individually. This study investigates the association of suicidal ideation with comorbid PTSD and depression and examines the role of military and psychosocial covariates. We evaluated 746 veterans using the CAPS to assess PTSD and the PHQ-9 to measure depression and suicidal ideation. Covariates were assessed via validated self-report measures...
April 22, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29751284/association-of-skin-autofluorescence-with-plaque-vulnerability-evaluated-by-optical-coherence-tomography-in-patients-with-cardiovascular-disease
#5
Yusuke Fujino, Guilherme F Attizzani, Satoko Tahara, Wei Wang, Kensuke Takagi, Toru Naganuma, Hiroto Yabushita, Kentaro Tanaka, Tomohiko Sato, Yusuke Watanabe, Satoru Mitomo, Naoyuki Kurita, Hisaaki Ishiguro, Shotaro Nakamura, Koji Hozawa, Hiram G Bezerra, Sho-Ichi Yamagishi, Sunao Nakamura
BACKGROUND AND AIMS: Accumulation of advanced glycation end products (AGEs) can be measured non-invasively by skin autofluorescence (SAF) whose values are elevated in patients with cardiovascular disease (CVD). Optical coherence tomography (OCT) is an intravascular imaging modality that could allow visualization of plaque composition. We aim to examine the relationship between SAF and plaque composition evaluated by frequency-domain OCT in patients with CVD. METHODS: We prospectively enrolled 108 patients with CVD, who underwent OCT images during percutaneous coronary intervention (PCI)...
March 2, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29746946/pneumonic-and-non-pneumonic-exacerbations-in-bronchiectasis-clinical-and-microbiological-differences
#6
Eva Polverino, Edmundo Rosales-Mayor, Mariana Benegas, Rosario Menendez, Victoria Alcaraz-Serrano, Emilio Ansotegui, Beatriz Montull, Rosa María Girón, Carolina Cisneros, Montserrat Vendrell, Gerard Muñoz, María Angeles Marcos, Marcelo Sanchez, Antoni Torres
OBJECTIVES: Despite the clinical relevance of exacerbations in bronchiectasis (BE), little is known about the microbiology and outcomes of pneumonic (CAP) vs. non-pneumonic (NOCAP) exacerbations. METHODS: This study compares clinical and microbiological characteristics of CAP vs. NOCAP in adults with BE. We performed a multicenter prospective observational study of consecutive cases of NOCAP and CAP from four Spanish hospitals (2011-2015). RESULTS: We recruited 144 patients, 47 of them CAP (33%) cases...
May 7, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29746377/risk-factors-for-severe-community-acquired-pneumonia-among-children-hospitalized-with-cap-younger-than-5-years-of-age
#7
Wei Shan, Ting Shi, Kaile Chen, Jian Xue, Yin Wang, Jia Yu, Genming Zhao, Jianmei Tian, Tao Zhang
BACKGROUND: CAP causes great morbidity and mortality as well as enormous economic burden worldwide. This study intended to describe the clinical characteristics of CAP and explore the risk factors of severe CAP among children in downtown Suzhou, China. METHODS: This was a retrospective study of childhood hospitalizations in Soochow University Affiliated Children's Hospital (SCH) from January 1, 2010 to December 31, 2014. Children who were residents of downtown Suzhou, 29 days to <5 years of age, with discharge diagnosis codes (ICD-10) J09 to J18 and J20 to J22 were included...
May 9, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29744447/in-vivo-evaluation-of-urokinase-loaded-hollow-nanogels-for-sonothrombolysis-on-suture-embolization-induced-acute-ischemic-stroke-rat-model
#8
Yuming Teng, Haiqiang Jin, Ding Nan, Mengnan Li, Chenghe Fan, Yuanyuan Liu, Pu Lv, Wei Cui, Yongan Sun, Hongjun Hao, Xiaozhong Qu, Zhenzhong Yang, Yining Huang
The urokinase-type plasminogen activator (uPA) loaded hollow nanogels (nUK) were synthesized by a one-step reaction of glycol chitosan and aldehyde capped poly (ethylene oxide). The resultant formulation is sensitive to diagnostic ultrasound (US) of 2 MHz. Herein, we evaluated the in vivo sonothrombolysis performance of the nUK on acute ischemic stroke rat model which was established by suture embolization of middle cerebral artery (MCA). Via intravenous (i.v.) administration, the experimental data prove a controlled release of the therapeutic protein around the clots under ultrasound stimulation, leading to enhanced thrombolysis efficiency of the nUK, evidenced from smaller infarct volume and better clinical scores when compared to the i...
March 2018: Bioactive Materials
https://www.readbyqxmd.com/read/29740122/differential-activity-of-transcribed-enhancers-in-the-prefrontal-cortex-of-537-cases-with-schizophrenia-and-controls
#9
Mads E Hauberg, John F Fullard, Lingxue Zhu, Ariella T Cohain, Claudia Giambartolomei, Ruth Misir, Sarah Reach, Jessica S Johnson, Minghui Wang, Manuel Mattheisen, Anders Dupont Børglum, Bin Zhang, Solveig K Sieberts, Mette A Peters, Enrico Domenici, Eric E Schadt, Bernie Devlin, Pamela Sklar, Kathryn Roeder, Panos Roussos
Transcription at enhancers is a widespread phenomenon which produces so-called enhancer RNA (eRNA) and occurs in an activity-dependent manner. However, the role of eRNA and its utility in exploring disease-associated changes in enhancer function, and the downstream coding transcripts that they regulate, is not well established. We used transcriptomic and epigenomic data to interrogate the relationship of eRNA transcription to disease status and how genetic variants alter enhancer transcriptional activity in the human brain...
May 8, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29736635/effect-of-distal-thickening-and-stiffening-of-plaque-cap-on-arterial-wall-mechanics
#10
Pengsrorn Chhai, Kyehan Rhee
To investigate the effect of longitudinal variations of cap thickness and tissue properties on wall stresses and strains along the atherosclerotic stenosis, stenotic plaque models (uniformly thick, distally thickened, homogenous, and distally stiffened) were constructed and subjected to computational stress analyses with due consideration of fluid-structure interactions (FSI). The analysis considered three different cap thicknesses-45, 65, and 200 μm-and tissue properties-soft, fibrous, and hard. The maximum peak cap stress (PCS) and strain were observed in the upstream throat section and demonstrated increases of the order of 345 and 190%, respectively, as the cap thickness was reduced from 200 to 45 μm in uniformly thick models...
May 8, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29732148/effect-of-molecular-hydrogen-on-uterine-inflammation-during-preterm-labour
#11
Tomoko Nakano, Tomomi Kotani, Kenji Imai, Yukako Iitani, Takafumi Ushida, Hiroyuki Tsuda, Hua Li, Akira Iwase, Shinya Toyokuni, Fumitaka Kikkawa
Intrauterine inflammation causes preterm birth and is associated with complications in preterm neonates. Thus, strategies aimed at suppressing inflammation are expected to be effective for reducing the risk of preterm birth and associated complications. Our previous studies demonstrated that molecular hydrogen (H2 ), an anti-inflammatory agent, prevented inflammation-induced impairment in foetal brain and lung tissues in lipopolysaccharide (LPS)-induced rodent models. However, it remains unclear whether H2 is capable of inhibiting preterm labour...
May 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29723821/capping-of-marine-sediments-with-valuable-industrial-by-products-evaluation-of-inorganic-pollutants-immobilization
#12
Mehwish Taneez, Charlotte Hurel, Franck Mady, Patrice Francour
In-situ capping of polluted sediment is considered as an inexpensive and effective treatment technology to immobilize contaminants in a short time. In this remediation technique sediments are capped by placing a layer of sand, clean sediment or other materials over sediments in order to mitigate risk. In this study, low cost industrial by products (bauxaline, steel slag, and mixture of the two products) were applied as capping agents. A bench scale laboratory experiment in aquariums was performed to evaluate their effects on Cd, Zn, As, and Cr mobility from an artificially contaminated marine sediment...
April 30, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29710871/characteristics-and-management-of-community-acquired-pneumonia-in-the-era-of-global-aging
#13
REVIEW
Catia Cillóniz, Diana Rodríguez-Hurtado, Antoni Torres
Community-acquired pneumonia (CAP) can occur at any time of life, but its incidence and risk of death are linked to increasing age. CAP in the elderly is a major health problem associated with high rates of readmission, morbidity, and mortality. Since the clinical presentation of pneumonia in the elderly may be atypical, clinicians should suspect pneumonia in older patients presenting symptoms such as falls and altered mental status, fatigue, lethargy, delirium, anorexia, in order to avoid the complications associated with delayed diagnosis and therapy...
April 30, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29702998/return-to-health-effect-of-modern-combined-antiretroviral-therapy-potentially-predisposes-hiv-patients-to-hepatic-steatosis
#14
Raphael Mohr, Christoph Boesecke, Leona Dold, Robert Schierwagen, Carolynne Schwarze-Zander, Jan-Christian Wasmuth, Insa Weisensee, Jürgen Kurt Rockstroh, Jonel Trebicka
Prevalence and risk factors for hepatic steatosis (HS) in the human immunodeficiency virus (HIV)-positive population of western countries are controversially discussed and potentially confounded by coinfection with viral hepatitis. Significant HS (more than 10% of hepatocytes) can be accurately assessed using controlled attenuation parameter (CAP) determination. Aim of this study was to assess prevalence and factors associated with significant HS in HIV monoinfected patients.A total of 364 HIV-infected patients (289 monoinfected) were included in this prospective, cross-sectional study...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29699493/effects-of-age-comorbidity-and-adherence-to-current-antimicrobial-guidelines-on-mortality-in-hospitalized-elderly-patients-with-community-acquired-pneumonia
#15
Xiudi Han, Fei Zhou, Hui Li, Xiqian Xing, Liang Chen, Yimin Wang, Chunxiao Zhang, Xuedong Liu, Lijun Suo, Jinxiang Wang, Guohua Yu, Guangqiang Wang, Xuexin Yao, Hongxia Yu, Lei Wang, Meng Liu, Chunxue Xue, Bo Liu, Xiaoli Zhu, Yanli Li, Ying Xiao, Xiaojing Cui, Lijuan Li, Jay E Purdy, Bin Cao
BACKGROUND: Limited information exists on the clinical characteristics predictive of mortality in patients aged ≥65 years in many countries. The impact of adherence to current antimicrobial guidelines on the mortality of hospitalized elderly patients with community-acquired pneumonia (CAP) has never been assessed. METHODS: A total of 3131 patients aged ≥65 years were enrolled from a multi-center, retrospective, observational study initiated by the CAP-China network...
April 24, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29699379/endoscopic-features-of-mucous-cap-polyps-a-way-to-predict-serrated-polyps
#16
Brian T Moy, Faripour Forouhar, Chia-Ling Kuo, Thomas J Devers
Background/Aims: The aims of the study were to identify whether a mucous-cap predicts the presence of serrated polyps, and to determine whether additional endoscopic findings predict the presence of a sessile serrated adenomas/polyp (SSA/P). Methods: We analyzed 147 mucous-capped polyps with corresponding histology, during 2011-2014. Eight endoscopic features (presence of borders, elevation, rim of debris, location in the colon, size ≥10 mm, varicose vessels, nodularity, and alteration in mucosal folds) of mucous-capped polyps were examined to see if they can predict SSA/Ps...
April 27, 2018: Clinical Endoscopy
https://www.readbyqxmd.com/read/29691103/the-risk-stratification-and-prognostic-prediction-value-of-procalcitonin-and-clinical-severity-scores-on-patients-with-community-acquired-pneumonia-in-emergency-department-prediction-value-of-procalcitonin-and-severity-scores-for-cap
#17
Haijiang Zhou, Shubin Guo, Tianfei Lan, Shuai Ma, Fang Zhang, Zhiling Zhao
OBJECTIVE: Community-acquired pneumonia (CAP) is a common presentation to the emergency department (ED) and has high mortality rates. The aim of our study is to investigate the risk stratification and prognostic prediction value of precalcitonin (PCT) and clinical severity scores on patients with CAP in ED. METHODS: 226 consecutive adult patients with CAP admitted in ED of a tertiary teaching hospital were enrolled. Demographic information and clinical parameters including PCT levels were analyzed...
March 21, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29686706/efficient-self-assembly-of-mpeg-end-capped-porous-silica-as-a-redox-sensitive-nanocarrier-for-controlled-doxorubicin-delivery
#18
Anh Khoa Nguyen, Thi Hiep Nguyen, Bui Quoc Bao, Long Giang Bach, Dai Hai Nguyen
Porous nanosilica (PNS) has been regarded as a promising candidate for controlled delivery of anticancer drugs. Unmodified PNS-based nanocarriers, however, showed a burst release of encapsulated drugs, which may limit their clinical uses. In this report, PNS was surface conjugated with adamantylamine (ADA) via disulfide bridges (-SS-), PNS-SS-ADA, which was further modified with cyclodextrin-poly(ethylene glycol) methyl ether conjugate (CD-mPEG) to form a core@shell structure PNS-SS-ADA@CD-mPEG for redox triggered delivery of doxorubicin (DOX), DOX/PNS-SS-ADA@CD-mPEG...
2018: International Journal of Biomaterials
https://www.readbyqxmd.com/read/29684743/neuroendocrine-neoplasms-of-rectum-a-management-update
#19
REVIEW
Emilio Bertani, Davide Ravizza, Massimo Milione, Sara Massironi, Chiara Maria Grana, Dario Zerini, Alessandra Nella Piccioli, Giuseppe Spinoglio, Nicola Fazio
The estimated annual incidence of R-NENs is 1.04 per 100,000 persons although the real incidence may be underestimated, as not all R-NEN are systematically reported in registers. Also the prevalence has increased substantially, reflecting the rising incidence and indolent nature of R-NENs, showing the highest prevalence increase among all site of origin of NENs. The size of the tumor reveals the behavior of R-NENs where the risk for metastatic spread increases for lesions > 10 mm. Applying the WHO 2010 grading system to whole NENs originating in the gastroenteropancreatic system, R-NENs are classified as Well-Differentiated Neuroendocrine Tumors (WD-NET), which contain NET G1 and NET G2, and Poorly-Differentiated Carcinomas (PD-NEC) enclosing only G3 neoplasms for which the term carcinoma is applied...
April 6, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29670716/knowledge-attitude-and-practice-of-hepatitis-b-virus-infection-among-dental-students-and-interns-in-saudi-arabia
#20
Hashem-Motahir Al-Shamiri, Fadyah-Eid AlShalawi, Tahani-Mohammed AlJumah, Maha-Mohammad AlHarthi, Esraa-Mohammed AlAli, Hanan-Mohammed AlHarthi
Background: Hepatitis B virus (HBV) is a worldwide healthcare problem. Dental health care professionals are at a high risk of infection by HBV. The present study investigated the knowledge, attitude and practice of HBV infection among Saudi dental students and Interns in Saudi Arabia. Material and Methods: This was a questionnaire-based cross-sectional study. A self-administered questionnaire consisting of questions on students' knowledge, attitudes, and practices regarding HBV was used...
January 2018: Journal of Clinical and Experimental Dentistry
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