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https://www.readbyqxmd.com/read/27926871/in%C3%A2-vivo-visualization-of-cardiomyocyte-apicobasal-polarity-reveals-epithelial-to-mesenchymal-like-transition-during-cardiac-trabeculation
#1
Vanesa Jiménez-Amilburu, S Javad Rasouli, David W Staudt, Hiroyuki Nakajima, Ayano Chiba, Naoki Mochizuki, Didier Y R Stainier
Despite great strides in understanding cardiac trabeculation, many mechanistic aspects remain unclear. To elucidate how cardiomyocyte shape changes are regulated during this process, we engineered transgenes to label their apical and basolateral membranes. Using these tools, we observed that compact-layer cardiomyocytes are clearly polarized while delaminating cardiomyocytes have lost their polarity. The apical transgene also enabled the imaging of cardiomyocyte apical constriction in real time. Furthermore, we found that Neuregulin signaling and blood flow/cardiac contractility are required for cardiomyocyte apical constriction and depolarization...
December 6, 2016: Cell Reports
https://www.readbyqxmd.com/read/27924949/genetic-evidence-for-an-east-asian-origin-of-chinese-muslim-populations-dongxiang-and-hui
#2
Hong-Bing Yao, Chuan-Chao Wang, Xiaolan Tao, Lei Shang, Shao-Qing Wen, Bofeng Zhu, Longli Kang, Li Jin, Hui Li
There is a long-going debate on the genetic origin of Chinese Muslim populations, such as Uygur, Dongxiang, and Hui. However, genetic information for those Muslim populations except Uygur is extremely limited. In this study, we investigated the genetic structure and ancestry of Chinese Muslims by analyzing 15 autosomal short tandem repeats in 652 individuals from Dongxiang, Hui, and Han Chinese populations in Gansu province. Both genetic distance and Bayesian-clustering methods showed significant genetic homogeneity between the two Muslim populations and East Asian populations, suggesting a common genetic ancestry...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27923777/parent-and-clinician-preferences-for-an-asthma-app-to-promote-adolescent-self-management-a-formative-study
#3
Lorie L Geryk, Courtney A Roberts, Adam J Sage, Tamera Coyne-Beasley, Betsy L Sleath, Delesha M Carpenter
BACKGROUND: Most youth asthma apps are not designed with parent and clinician use in mind, and rarely is the app development process informed by parent or clinician input. OBJECTIVE: This study was conducted to generate formative data on the use, attitudes, and preferences for asthma mHealth app features among parents and clinicians, the important stakeholders who support adolescents with asthma and promote adolescent self-management skills. METHODS: We conducted a mixed-methods study from 2013 to 2014 employing a user-centered design philosophy to acquire feedback from a convenience sample of 20 parents and 6 clinicians...
December 6, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27919379/understanding-latent-structures-of-clinical-information-logistics-a-bottom-up-approach-for-model-building-and-validating-the-workflow-composite-score
#4
Moritz Esdar, Ursula Hübner, Jan-David Liebe, Jens Hüsers, Johannes Thye
BACKGROUND AND PURPOSE: Clinical information logistics is a construct that aims to describe and explain various phenomena of information provision to drive clinical processes. It can be measured by the workflow composite score, an aggregated indicator of the degree of IT support in clinical processes. This study primarily aimed to investigate the yet unknown empirical patterns constituting this construct. The second goal was to derive a data-driven weighting scheme for the constituents of the workflow composite score and to contrast this scheme with a literature based, top-down procedure...
January 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27919163/isotopes-to-assess-sustainability-of-overexploited-groundwater-in-the-souss-massa-system-morocco
#5
Mohammed Hssaisoune, Lhoussaine Bouchaou, Baudelaire N'da, Mouna Malki, Houria Abahous, Alan E Fryar
Groundwater depletion and changes in isotopic and chemical contents constitute the main indicators of overexploitation, recharge, and flow paths in the Souss-Massa aquifer. These indicators highlight processes concerning sustainability of water resources in the aquifer (e.g. surface/groundwater interaction, recharge processes, and marine intrusion). The spatial variation of stable and radioactive isotopic contents indicates a mixing of modern and old water within the system. Recent recharge was observed mainly along the Souss River (the major surface-water drainage in the study area) and in the irrigated areas...
December 5, 2016: Isotopes in Environmental and Health Studies
https://www.readbyqxmd.com/read/27918592/microrna-497-induces-apoptosis-and-suppresses-proliferation-via-the-bcl-2-bax-caspase9-caspase3-pathway-and-cyclin-d2-protein-in-huvecs
#6
Ridong Wu, Shi Tang, Mian Wang, Xiangdong Xu, Chen Yao, Shenming Wang
INTRODUCTION: MicroRNAs play crucial roles in various types of diseases. However, to date, no information about the role of miR-497 in the development of atherosclerosis has been reported. This study investigated the possible role of miR-497 in vascular endothelial cell injury during the early stage of atherosclerosis. MATERIALS AND METHODS: The expression level of miR-497 in human umbilical vein endothelial cells (HUVECs) exposed to ox-LDL was detected using qRT-PCR...
2016: PloS One
https://www.readbyqxmd.com/read/27917521/international-continence-society-good-urodynamic-practices-and-terms-2016-urodynamics-uroflowmetry-cystometry-and-pressure-flow-study
#7
REVIEW
Peter F W M Rosier, Werner Schaefer, Gunnar Lose, Howard B Goldman, Michael Guralnick, Sharon Eustice, Tamara Dickinson, Hashim Hashim
AIMS: The working group initiated by the ICS Standardisation Steering Committee has updated the International Continence Society Standard "Good Urodynamic Practice" published in 2002. METHODS: On the basis of the manuscript: "ICS standard to develop evidence-based standards," a new ICS Standard was developed in the period from December 2013 to December 2015. In July, a draft was posted on the ICS website for membership comments and discussed at the ICS 2015 annual meeting...
December 5, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27916116/atmospheric-pressure-solution-cathode-glow-discharge-a-versatile-ion-source-for-atomic-and-molecular-mass-spectrometry
#8
Andrew J Schwartz, Kelsey L Williams, Gary M Hieftje, Jacob T Shelley
An atmospheric-pressure solution-cathode glow discharge (SCGD) has been evaluated as an ion source for atomic, molecular, and ambient desorption/ionization mass spectrometry. The SCGD consists of a direct-current plasma, supported in the ambient air in the absence of gas flows, and sustained upon the surface of a flowing liquid cathode. Analytes introduced in the flowing liquid, as an ambient gas, or as a solid held near the plasma are vaporized and ionized by interactions within or near the discharge. Introduction of acidic solutions containing metal salts produced bare elemental ions as well as H2O, OH(-) and NO3(-) adducts...
January 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27914630/uterine-blood-flow-in-sheep-and-goats-during-the-peri-parturient-period-assessed-by-transrectal-doppler-sonography
#9
Mohammed Elmetwally, Heinrich Bollwein
The aim of the present study was to evaluate uterine blood flow (UBF) during the postpartum period in small ruminants. The study involved measures of UBF in 5 ewes and 5 goats during the first 4 weeks after parturition. Transrectal quantification of UBF was assessed by determining the diameter (DM), time averaged mean velocity (TAMEAN), blood flow volume (BFV), blood flow acceleration (ACCE) and pulsatility index (PI) in the uterine arteries ipsilateral to the previously gravid uterine horn(s) at Wk 20 of gestation and every 3days from the day of parturition (D 0) until Day 27 postpartum (D 27)...
November 25, 2016: Animal Reproduction Science
https://www.readbyqxmd.com/read/27914203/multiple-processes-drive-genetic-structure-of-humpback-whale-megaptera-novaeangliae-populations-across-spatial-scales
#10
Francine Kershaw, Inês Carvalho, Jacqueline Loo, Cristina Pomilla, Peter B Best, Ken P Findlay, Salvatore Cerchio, Tim Collins, Marcia H Engel, Gianna Minton, Peter Ersts, Jaco Barendse, P G H Kotze, Yvette Razafindrakoto, Solange Ngouessono, Michael Meÿer, Meredith Thorton, Howard C Rosenbaum
Elucidating patterns of population structure for species with complex life histories, and disentangling the processes driving such patterns, remains a significant analytical challenge. Humpback whale (Megaptera novaeangliae) populations display complex genetic structures that have not been fully resolved at all spatial scales. We generated a data set of nuclear markers for 3,575 samples spanning the seven breeding stocks and substocks found in the South Atlantic and western and northern Indian Oceans. For the total sample, and males and females separately, we assessed genetic diversity, tested for genetic differentiation between putative populations and isolation by distance, estimated the number of genetic clusters without a priori population information, and estimated rates of gene flow using maximum likelihood and Bayesian approaches...
December 3, 2016: Molecular Ecology
https://www.readbyqxmd.com/read/27914006/accurate-myocardial-blood-flow-measurements-quality-from-start-to-finish-is-key-to-success
#11
EDITORIAL
James Case
Overall repeatability and accuracy of myocardial blood flow measurements depend on the quality of the image data, the proper use of the quantitative software, and the training of clinical staff. Unlike most imaging tests, absolute blood flow measurements have the potential to provide accurate information beyond what is seen visually. This additive information has been shown to help identify multivessel disease, balanced ischemia, true normal studies, and quality control problems that may not be visible in the relative perfusion pattern...
December 2, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27913502/mrd-in-aml-does-it-already-guide-therapy-decision-making
#12
Gert Ossenkoppele, Gerrit Jan Schuurhuis
Prognostic factors determined at diagnosis are predictive for outcome whereas achievement of morphological complete remission (CR) is still an important end point during treatment. Residual disease after therapy may reflect the sum of all diagnosis and postdiagnosis resistance mechanisms/factors; its measurement could hypothetically be very instrumental for guiding treatment. The possibility of defining residual disease (minimal residual disease [MRD]) far below the level of 5% blast cells is changing the landscape of risk classification...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27913429/heritability-of-the-effective-connectivity-in-the-resting-state-default-mode-network
#13
Junhai Xu, Xuntao Yin, Haitao Ge, Yan Han, Zengchang Pang, Baolin Liu, Shuwei Liu, Karl Friston
The default mode network (DMN) is thought to reflect endogenous neural activity, which is considered as one of the most intriguing phenomena in cognitive neuroscience. Previous studies have found that key regions within the DMN are highly interconnected. Here, we characterized the genetic influences on causal or directed information flow within the DMN during the resting state. In this study, we recruited 46 pairs of twins and collected fMRI imaging data using a 3.0 T scanner. Dynamic causal modeling was conducted for each participant, and a structural equation model was used to calculate the heritability of DMN in terms of its effective connectivity...
November 23, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27912200/is-cha2ds2-vasc-appropriate-for-hyperthyroid-patients-with-atrial-fibrillation-implications-of-adding-a-transesophageal-echocardiography-evaluation
#14
Marcus Vinicius Leitão de Souza, Patricia de Fátima Dos Santos Teixeira, Mario Vaisman, Sergio Salles Xavier
BACKGROUND: Anticoagulation remains a controversial issue among hyperthyroid patients with atrial fibrillation (AF). We aimed to evaluate the prevalence of the thrombogenic milieu (TM), detected using transesophageal echocardiography (TEE), among patients with AF related to hyperthyroidism, and to correlate these findings with the clinical embolic risk classification (CHA2DS2-VASc). METHODS: CHA2DS2-VASc score, thyroid hormonal status, time since hyperthyroidism diagnosis, transthoracic echocardiography (TTE) and TEE were assessed in 47 consecutive patients aged between 18 and 65years with AF related to hyperthyroidism...
November 10, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27911421/-analysis-of-changes-in-central-macular-thickness-based-on-optical-coherence-tomography-angiography-findings-in-retinal-vein-occlusion
#15
M V Budzinskaya, A V Shelankova, M A Mikhailova, A A Plyukhova, N M Nurieva, A V Fomin
AIM: To investigate the relationship between OCT angiography measurements and central fundus changes in patients with retinal vein occlusion (RVO). MATERIAL AND METHODS: The study enrolled 21 RVO patients aged from 55 to 86 years (69.9±2.28 years), including 8 patients with ischemic central RVO (I-CRVO; 73.6±3.4 years on average) and 13 patients with branch RVO (BRVO; 67.6±3.0 years on average). Of the latter, 8 cases were ischemic (I-BRVO) and 5 non-ischemic (NI-BRVO)...
2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27911410/experimental-infection-with-listeria-monocytogenes-as-a-model-for-studying-host-interferon-%C3%AE-responses
#16
Jeeyoon Jennifer Ahn, Thirumahal Selvanantham, Monan Angela Zhang, Thierry Mallevaey, Shannon E Dunn
L. monocytogenes is a gram-positive bacterium that is a cause of food borne disease in humans. Experimental infection of mice with this pathogen has been highly informative on the role of innate and adaptive immune cells and specific cytokines in host immunity against intracellular pathogens. Production of IFN-γ by innate cells during sublethal infection with L. monocytogenes is important for activating macrophages and early control of the pathogen(1-3). In addition, IFN-γ production by adaptive memory lymphocytes is important for priming the activation of innate cells upon reinfection(4)...
November 16, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27910869/multiparameter-mechanical-and-morphometric-screening-of-cells
#17
Mahdokht Masaeli, Dewal Gupta, Sean O'Byrne, Henry T K Tse, Daniel R Gossett, Peter Tseng, Andrew S Utada, Hea-Jin Jung, Stephen Young, Amander T Clark, Dino Di Carlo
We introduce a label-free method to rapidly phenotype and classify cells purely based on physical properties. We extract 15 biophysical parameters from cells as they deform in a microfluidic stretching flow field via high-speed microscopy and apply machine-learning approaches to discriminate different cell types and states. When employing the full 15 dimensional dataset, the technique robustly classifies individual cells based on their pluripotency, with accuracy above 95%. Rheological and morphological properties of cells while deforming were critical for this classification...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27910522/design-and-characterization-of-a-linear-hencken-type-burner
#18
M F Campbell, G A Bohlin, P E Schrader, R P Bambha, C J Kliewer, K O Johansson, H A Michelsen
We have designed and constructed a Hencken-type burner that produces a 38-mm-long linear laminar partially premixed co-flow diffusion flame. This burner was designed to produce a linear flame for studies of soot chemistry, combining the benefit of the conventional Hencken burner's laminar flames with the advantage of the slot burner's geometry for optical measurements requiring a long interaction distance. It is suitable for measurements using optical imaging diagnostics, line-of-sight optical techniques, or off-axis optical-scattering methods requiring either a long or short path length through the flame...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910467/the-magnetic-recoil-spectrometer-mrst-for-time-resolved-measurements-of-the-neutron-spectrum-at-the-national-ignition-facility-nif
#19
J A Frenje, T J Hilsabeck, C W Wink, P Bell, R Bionta, C Cerjan, M Gatu Johnson, J D Kilkenny, C K Li, F H Séguin, R D Petrasso
The next-generation magnetic recoil spectrometer for time-resolved measurements of the neutron spectrum has been conceptually designed for the National Ignition Facility. This spectrometer, called MRSt, represents a paradigm shift in our thinking about neutron spectrometry for inertial confinement fusion applications, as it will provide simultaneously information about the burn history and time evolution of areal density (ρR), apparent ion temperature (Ti), yield (Yn), and macroscopic flows during burn. From this type of data, an assessment of the evolution of the fuel assembly, hotspot, and alpha heating can be made...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27907928/cytomorphological-analysis-of-lymph-node-lesions-in-hiv-positive-patients-with-cd4-count-correlation-a-cross-sectional-study
#20
Sadia Siddiqa Nasser, Rashmi K Patil, Shreekanth K Kittur
OBJECTIVES: To study the cytomorphological spectrum of lymph node lesions in HIV-positive patients and correlate the cytological findings with the CD4 count. STUDY DESIGN: This was a cross-sectional study of 23 months' duration which included 110 HIV-positive cases proved according to the guidelines of the National AIDS Control Organisation. Fine-needle aspiration cytology (FNAC) was done on clinically palpable lymph nodes. Special stains and culture were done wherever necessary...
December 2, 2016: Acta Cytologica
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