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https://www.readbyqxmd.com/read/29785839/optimization-of-a-secondary-voi-protocol-for-lung-imaging-in-a-clinical-ct-scanner
#1
Thomas C Larsen, Vissagan Gopalakrishnan, Jianhua Yao, Catherine P Nguyen, Marcus Y Chen, Joel Moss, Han Wen
We present a solution to meet an unmet clinical need of an in-situ "close look" at a pulmonary nodule or at the margins of a pulmonary cyst revealed by a primary (screening) chest CT while the patient is still in the scanner. We first evaluated options available on current whole-body CT scanners for high resolution screening scans, including ROI reconstruction of the primary scan data and HRCT, but found them to have insufficient SNR in lung tissue or discontinuous slice coverage. Within the capabilities of current clinical CT systems, we opted for the solution of a secondary, volume-of-interest (VOI) protocol where the radiation dose is focused into a short-beam axial scan at the z position of interest, combined with a small-FOV reconstruction at the xy position of interest...
May 21, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29783114/geosphere-biosphere-circulation-of-chemical-elements-in-soil-and-plant-systems-from-a-100-km-transect-from-southern-central-norway
#2
Clemens Reimann, Karl Fabian, Belinda Flem, Malin Andersson, Peter Filzmoser, Peter Englmaier
Geochemical element separation is studied in 14 different sample media collected at 41 sites along an approximately 100-km long transect north of Oslo. At each site, soil C and O horizons and 12 plant materials (birch/spruce/cowberry/blueberry leaves/needles and twigs, horsetail, braken fern, pine bark and terrestrial moss) were sampled. The observed concentrations of 29 elements (K, Ca, P, Mg, Mn, S, Fe, Zn, Na, B, Cu, Mo, Co, Al, Ba, Rb, Sr, Ti, Ni, Pb, Cs, Cd, Ce, Sn, La, Tl, Y, Hg, Ag) were used to investigate soil-plant relations, and to evaluate the element differentiation between different plants, or between foliage and twigs of the same plant...
May 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29781523/a-case-study-illustrating-the-use-of-an-attachment-video-feedback-intervention-strategy
#3
George M Tarabulsy, Karine Dubois-Comtois, Claire Baudry, Ellen Moss, Annie Roberge, Laura-Emilie Savage, Chantal Cyr, Diane St-Laurent, Annie Bernier
Children from high-risk environments are more likely to experience problems in development. Many difficulties are linked to early experiences in the context of the emerging attachment relationship. Over the past 20 years, our group has collaborated with government agencies to develop and implement an attachment-based video-feedback intervention strategy (AVI) that targets parental sensitivity and attachment. This case study presents the manner in which a young mother and her 6-month-old son experienced AVI...
May 21, 2018: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29781136/physcomitrella-patens-max2-characterization-suggests-an-ancient-role-for-this-f-box-protein-in-photomorphogenesis-rather-than-strigolactone-signalling
#4
Mauricio Lopez-Obando, Ruan de Villiers, Beate Hoffmann, Linnan Ma, Alexandre de Saint Germain, Jens Kossmann, Yoan Coudert, C Jill Harrison, Catherine Rameau, Paul Hills, Sandrine Bonhomme
Strigolactones (SLs) are key hormonal regulators of flowering plant development and are widely distributed amongst streptophytes. In Arabidopsis, SLs signal via the F-box protein MORE AXILLARY GROWTH2 (MAX2), affecting multiple aspects of development including shoot branching, root architecture and drought tolerance. Previous characterization of a Physcomitrella patens moss mutant with defective SL synthesis supports an ancient role for SLs in land plants, but the origin and evolution of signalling pathway components are unknown...
May 21, 2018: New Phytologist
https://www.readbyqxmd.com/read/29779657/collection-culturing-and-genome-analyses-of-tropical-marine-filamentous-benthic-cyanobacteria
#5
Nathan A Moss, Tiago Leao, Evgenia Glukhov, Lena Gerwick, William H Gerwick
Decreasing sequencing costs has sparked widespread investigation of the use of microbial genomics to accelerate the discovery and development of natural products for therapeutic uses. Tropical marine filamentous cyanobacteria have historically produced many structurally novel natural products, and therefore present an excellent opportunity for the systematic discovery of new metabolites via the information derived from genomics and molecular genetics. Adequate knowledge transfer and institutional know-how are important to maintain the capability for studying filamentous cyanobacteria due to their unusual microbial morphology and characteristics...
2018: Methods in Enzymology
https://www.readbyqxmd.com/read/29777775/genome-analysis-of-the-ancient-tracheophyte-selaginella-tamariscina-reveals-evolutionary-features-relevant-to-the-acquisition-of-desiccation-tolerance
#6
Zhichao Xu, Tianyi Xin, Dorothea Bartels, Ying Li, Wei Gu, Hui Yao, Sai Liu, Haoying Yu, Xiangdong Pu, Jianguo Zhou, Jiang Xu, Caicai Xi, Hetian Lei, Jingyuan Song, Shilin Chen
Resurrection plants, which are the "gifts" of natural evolution, are ideal models for studying genetic basis of plant desiccation tolerance. Here, we report a high-quality genome assembly of 301 Mb for the diploid spike moss Selaginella tamariscina, a primitive vascular resurrection plant. We predicated 27,761 protein-coding genes from the assembled S. tamariscina genome, 11.38% (2363) of which showed significant expression changes in response to desiccation. Approximately 60.58% of the S. tamariscina genome was annotated as repetitive DNA, which is almost 2-fold increase of that in the genome of desiccation-sensitive S...
May 16, 2018: Molecular Plant
https://www.readbyqxmd.com/read/29774861/use-of-bead-based-serologic-assay-to-evaluate-chikungunya-virus-epidemic-haiti
#7
Eric W Rogier, Delynn M Moss, Kimberly E Mace, Michelle Chang, Samuel E Jean, Stevan M Bullard, Patrick J Lammie, Jean Frantz Lemoine, Venkatachalam Udhayakumar
The index case of chikungunya virus (CHIKV) in Haiti was reported during early 2014; the vector, the pervasive Aedes aegypti mosquito, promoted rapid spread throughout the country. During December 2014-February 2015, we collected blood samples from 4,438 persons at 154 sites (62 urban, 92 rural) throughout Haiti and measured CHIKV IgG by using a multiplex bead assay. Overall CHIKV seroprevalence was 57.9%; differences between rural (mean 44.9%) and urban (mean 78.4%) areas were pronounced. Logistic modeling identified the urban environment as a strong predictor of CHIKV exposure (adjusted odds ratio 3...
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29773165/arthur-j-moss-md-in-memoriam
#8
EDITORIAL
Eric N Prystowsky, James P Daubert
No abstract text is available yet for this article.
May 22, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29772298/abietane-diterpenoids-from-lycopodium-complanatum
#9
YanMei Weng, Xia Yu, Jing Li, QiuZhu Dong, FuShuang Li, Fei Cheng, Yan Zhang, CaiPing Yao, ZhenXing Zou, WenHao Zhou, GuiShan Tan, KangPing Xu
Five new abietane diterpenoids (complanatins A-E, 1-5) have been isolated from the club moss Lycopodium complanatum, along with two known abietane diterpenoids (xanthoperol and sugiol). Their structures were determined by comprehensive analysis of 1D, 2D NMR, CD and HRESIMS data. The cytotoxic effects of five compounds (1-4, 7) were evaluated in three human lung cancer cell lines (MSTO-211H, NCI-H2052 and NCI-H226). Compounds 3 and 4 exhibited cytotoxic activities against the three cell lines. In addition, a plausible biogenetic pathway of compounds 1-7 was proposed...
May 14, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29772086/physcomitrella-patens-reute-mcherry-as-a-tool-for-efficient-crossing-within-and-between-ecotypes
#10
Pierre-François Perroud, Rabea Meyberg, Stefan A Rensing
Physcomitrella patens is a monoicous moss that is predominantly selfing in the wild. Laboratory crossing techniques have been established and crosses between the sequenced Gransden ecotype and the genetically divergent Villersexel ecotype were used for genetic mapping. The recently introduced ecotype Reute displays a high fertility rate and is genetically more closely related to the Gransden reference genome than the Villersexel ecotype. The Reute sexual reproduction phenology is similar to Gransden, which should allow successful crossing...
May 17, 2018: Plant Biology
https://www.readbyqxmd.com/read/29771792/using-a-social-network-strategy-to-distribute-hiv-self-test-kits-to-african-american-and-latino-msm
#11
Marguerita A Lightfoot, Chadwick K Campbell, Nicholas Moss, Sarah Treves-Kagan, Emily Agnew, Mi-Suk Kang Dufour, Hyman Scott, Aria M Sa'id, Sheri A Lippman
BACKGROUND: Men who have sex with men (MSM) continue to be disproportionately impacted globally by the HIV epidemic. Studies suggest that HIV Self-testing (HIVST) is highly acceptable among MSM. Social network strategies to increase testing are effective in reaching MSM, particularly MSM of color, who may not otherwise test. We tested a social-network based strategy to distribute HIVST kits to African American and Latino MSM. SETTING: This study was conducted in Alameda County, California a large, urban/suburban county with an HIV epidemic mirroring the national HIV epidemic...
May 4, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29770978/arthur-j-moss-1931-2018
#12
Wojciech Zareba
No abstract text is available yet for this article.
May 17, 2018: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/29769441/unique-features-and-clinical-importance-of-acute-alloreactive-immune-responses
#13
Charlotte F Inman, Suzy A Eldershaw, Joanne E Croudace, Nathaniel J Davies, Archana Sharma-Oates, Tanuja Rai, Hayden Pearce, Mirjana Sirovica, Y L Tracey Chan, Kriti Verma, Jianmin Zuo, Sandeep Nagra, Francesca Kinsella, Jane Nunnick, Rasoul Amel-Kashipaz, Charles Craddock, Ram Malladi, Paul Moss
Allogeneic stem cell transplantation (allo-SCT) can cure some patients with hematopoietic malignancy, but this relies on the development of a donor T cell alloreactive immune response. T cell activity in the first 2 weeks after allo-SCT is crucial in determining outcome, despite the clinical effects of the early alloreactive immune response often not appearing until later. However, the effect of the allogeneic environment on T cells is difficult to study at this time point due to the effects of profound lymphopenia...
May 17, 2018: JCI Insight
https://www.readbyqxmd.com/read/29769137/laboratory-studies-on-the-oviposition-stimuli-of-culicoides-stellifer-diptera-ceratopogonidae-a-suspected-vector-of-orbiviruses-in-the-united-states
#14
Dinesh Erram, Nathan Burkett-Cadena
BACKGROUND: Biting midges of the genus Culicoides (Diptera: Ceratopogonidae) exert a significant impact on animal agriculture worldwide because they transmit bluetongue virus (BTV) and epizootic hemorrhagic disease virus (EHDV) to ruminants. Without effective vaccines, BTV/EHDV vector management strategies are needed, particularly in commercial white-tailed deer (WTD) facilities. However, detailed information on the ecology of midge immatures in/around cervid operations is currently lacking...
May 16, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29768506/genome-wide-classification-evolutionary-analysis-and-gene-expression-patterns-of-the-kinome-in-gossypium
#15
Jun Yan, Guilin Li, Xingqi Guo, Yang Li, Xuecheng Cao
The protein kinase (PK, kinome) family is one of the largest families in plants and regulates almost all aspects of plant processes, including plant development and stress responses. Despite their important functions, comprehensive functional classification, evolutionary analysis and expression patterns of the cotton PK gene family has yet to be performed on PK genes. In this study, we identified the cotton kinomes in the Gossypium raimondii, Gossypium arboretum, Gossypium hirsutum and Gossypium barbadense genomes and classified them into 7 groups and 122-24 subfamilies using software HMMER v3...
2018: PloS One
https://www.readbyqxmd.com/read/29764433/detection-of-anopheles-rivulorum-like-a-member-of-the-anopheles-funestus-group-in-south-africa
#16
Joel Mouatcho, Anthony J Cornel, Yael Dahan-Moss, Lizette L Koekemoer, Maureen Coetzee, Leo Braack
BACKGROUND: The Anopheles gambiae sensu lato (s.l.) and Anopheles funestus s.l. species complexes contain the most important malaria vectors in Africa. Within the An. funestus group of at least 11 African species, the vector status of all but the nominal species An. funestus appears poorly investigated, although evidence exists that Anopheles rivulorum and Anopheles vaneedeni may play minor roles. A new species, An. rivulorum-like, was described from Burkina Faso in 2000 and subsequently also found in Cameroon and Zambia...
May 15, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29763861/source-discrimination-of-atmospheric-metal-deposition-by-multi-metal-isotopes-in-the-three-gorges-reservoir-region-china
#17
Jinling Liu, Xiangyang Bi, Fanglin Li, Pengcong Wang, Jin Wu
Concentrations of heavy metals, as well as isotopic compositions of mercury (Hg) and lead (Pb), in mosses (Bryum argenteum) from the Three Gorges Reservoir (TGR) region were investigated to decipher the sources of atmospheric metals in this region. Higher contents of metals (0.90 ± 0.65 mg/kg of Cd, 24.6 ± 27.4 mg/kg of Cu, and 36.1 ± 51.1 mg/kg of Pb) in the mosses from TGR were found compared with those from pollution-free regions. Principal component analysis (PCA) grouped the moss metals into four main components which were associated with both anthropogenic and natural sources...
May 12, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29762159/vitamin-d-in-inflammatory-bowel-disease-more-than-just-a-supplement
#18
John Gubatan, Alan C Moss
PURPOSE OF REVIEW: The aim of this review is to explore the protective role of vitamin D on the gastrointestinal tract, summarize the epidemiology of vitamin D deficiency in inflammatory bowel disease (IBD), and highlight recent studies examining the impact of low vitamin D and vitamin D supplementation on IBD clinical outcomes. RECENT FINDINGS: Vitamin D protects the gut barrier by regulating tight junction proteins and inhibiting intestinal apoptosis. Vitamin D enhances innate immunity by inducing antimicrobial peptides and regulates adaptive immunity by promoting anti-inflammatory T cells and cytokines...
May 11, 2018: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/29761861/implantable-cardioverter-defibrillators-in-heart-failure-patients-with-reduced-ejection-fraction-and-diabetes
#19
Abhinav Sharma, Sana M Al-Khatib, Justin A Ezekowitz, Lauren B Cooper, Christopher B Fordyce, G Michael Felker, Gust H Bardy, Jeanne E Poole, J Thomas Bigger, Alfred E Buxton, Arthur J Moss, Daniel J Friedman, Kerry L Lee, Richard Steinman, Paul Dorian, Riccardo Cappato, Alan H Kadish, Peter J Kudenchuk, Daniel B Mark, Eric D Peterson, Lurdes Y T Inoue, Gillian D Sanders
AIM: There is limited information on the outcomes after primary prevention implantable cardioverter-defibrillator (ICD) implantation in patients with heart failure (HF) and diabetes. This analysis evaluates the effectiveness of a strategy of ICD plus medical therapy vs. medical therapy alone among patients with HF and diabetes. METHODS AND RESULTS: A patient-level combined-analysis was conducted from a combined dataset that included four primary prevention ICD trials of patients with HF or severely reduced ejection fractions: Multicenter Automatic Defibrillator Implantation Trial I (MADIT I), MADIT II, Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation (DEFINITE), and Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT)...
May 15, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29759673/characterization-of-ventricular-tachycardia-after-left-ventricular-assist-device-implantation-as-destination-therapy-a-single-center-ablation-experience
#20
Joshua D Moss, Erin E Flatley, Andrew D Beaser, John H Shin, Hemal M Nayak, Gaurav A Upadhyay, Martin C Burke, Valluvan Jeevanandam, Nir Uriel, Roderick Tung
OBJECTIVES: This study sought to report mechanisms of ventricular tachycardia (VT) and outcomes of VT ablation in patients with a left ventricular assist device (LVAD) as destination therapy. BACKGROUND: Continuous flow LVAD implantation plays a growing role in the management of end-stage heart failure, and VT is common. There are limited reports of VT ablation in patients with a destination LVAD. METHODS: Patients with a continuous-flow LVAD referred for VT ablation from 2010 to 2016 were analyzed retrospectively...
December 11, 2017: JACC. Clinical Electrophysiology
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