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https://www.readbyqxmd.com/read/29346351/adolescents-and-young-adults-with-cancer-in-new-zealand-understudied-and-underserved
#1
EDITORIAL
Heidi Watson, Rochelle Moss
No abstract text is available yet for this article.
January 19, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29345034/precipitation-frequency-alters-peatland-ecosystem-structure-and-co2-exchange-contrasting-effects-on-moss-sedge-and-shrub-communities
#2
Danielle D Radu, Tim P Duval
Climate projections forecast a redistribution of seasonal precipitation for much of the globe into fewer, larger events spaced between longer dry periods, with negligible changes in seasonal rainfall totals. This intensification of the rainfall regime is expected to alter near-surface water availability, which will affect plant performance and carbon uptake. This could be especially important in peatland systems, where large stores of carbon are tightly coupled to water surpluses limiting decomposition. Here, we examined the role of precipitation frequency on vegetation growth and carbon dioxide (CO2 ) balances for communities dominated by a Sphagnum moss, a sedge, and an ericaceous shrub in a cool temperate poor fen...
January 18, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29344070/diffuse-colour-discrimination-as-marker-of-afferent-visual-system-dysfunction-in-amyotrophic-lateral-sclerosis
#3
Lindsay Boven, Qin Li Jiang, Heather E Moss
Abnormalities of the inner and intermediate retinal structures in patients with amyotrophic lateral sclerosis (ALS) have been described using optical coherence tomography and histopathology. Colour vision is a potential marker of these structural changes. The purpose of this study is to test the hypothesis that colour vision impairment is associated with ALS. Monocular (right eye) colour vision was assessed in subjects with definite or probable ALS (n = 25, aged 50-80 years) and control (n = 21, aged 46-89 years) subjects with corrected near visual acuity of at least 20/40 using the L'Anthony D15 color test (desaturated), scored by c-index, a measure of diffuse colour discrimination...
December 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29344066/diagnostic-challenge-sequential-unilateral-cranial-neuropathies-due-to-perineural-spread-of-carcinoma
#4
Heather E Moss, Peter W MacIntosh, Konstantin V Slavin, John M Collins
An 86-year old man developed sequential dysfunction of trigeminal (V1), facial, abducens, trigeminal (v2), oculomotor, and hypoglossal cranial nerves on the right over 20 months. Magnetic resonance imaging (MRI) showed a lesion in the right cavernous sinus. Although there was clinical suspicion that this was related to perineural spread of an extracranial tumour, a primary lesion was not discovered. Stereotactic biopsies of the intracranial lesion were non-diagnostic, and the patient succumbed to his tumour following a period of rapid growth...
August 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29343579/identification-of-poxvirus-genome-uncoating-and-dna-replication-factors-with-mutually-redundant-roles
#5
Baoming Liu, Debasis Panda, Jorge D Mendez-Rios, Sundar Ganesan, Linda S Wyatt, Bernard Moss
Genome uncoating is essential for replication of most viruses. For poxviruses, the process is divided into two stages: removal of the envelope allowing early gene expression, and breaching of the core wall allowing DNA release, replication and late gene expression. Subsequent studies showed that the host proteasome and the viral D5 protein, which has an essential role in DNA replication, are required for vaccinia virus (VACV) genome uncoating. In a search for additional VACV uncoating proteins, we noted a report that described a defect in DNA replication and late expression when the gene encoding a 68 kDa ankyrin-repeat/F box protein (68k-ank), associated with the cellular SCF ubiquitin ligase complex, was deleted from the attenuated modified vaccinia virus Ankara (MVA)...
January 17, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29342939/deciphering-the-evolution-and-development-of-the-cuticle-by-studying-lipid-transfer-proteins-in-mosses-and-liverworts
#6
REVIEW
Tiina A Salminen, D Magnus Eklund, Valentin Joly, Kristina Blomqvist, Daniel P Matton, Johan Edqvist
When plants conquered land, they developed specialized organs, tissues, and cells in order to survive in this new and harsh terrestrial environment. New cell polymers such as the hydrophobic lipid-based polyesters cutin, suberin, and sporopollenin were also developed for protection against water loss, radiation, and other potentially harmful abiotic factors. Cutin and waxes are the main components of the cuticle, which is the waterproof layer covering the epidermis of many aerial organs of land plants. Although the in vivo functions of the group of lipid binding proteins known as lipid transfer proteins (LTPs) are still rather unclear, there is accumulating evidence suggesting a role for LTPs in the transfer and deposition of monomers required for cuticle assembly...
January 15, 2018: Plants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29341138/model-fitting-for-small-skin-permeability-data-sets-hyperparameter-optimisation-in-gaussian-process-regression
#7
Parivash Ashrafi, Yi Sun, Neil Davey, Roderick G Adams, Simon C Wilkinson, Gary Patrick Moss
OBJECTIVES: The aim of this study was to investigate how to improve predictions from Gaussian Process models by optimising the model hyperparameters. METHODS: Optimisation methods, including Grid Search, Conjugate Gradient, Random Search, Evolutionary Algorithm and Hyper-prior, were evaluated and applied to previously published data. Data sets were also altered in a structured manner to reduce their size, which retained the range, or 'chemical space' of the key descriptors to assess the effect of the data range on model quality...
January 17, 2018: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29340382/tuning-the-indirect-direct-band-gap-transition-in-the-mos2-xsex-armchair-nanotube-by-diameter-modulation
#8
Hong-Hui Wu, Qiangqiang Meng, He Huang, C T Liu, Xun-Li Wang
The application of the reported armchair transition-metal dichalcogenide (MoS2, MoTe2, MoSTe and WS2, etc.) nanotube is hindered for the optoelectronic devices due to the indirect band gap. By using first-principles calculations, the electronic structures of MoS2-xSex single-wall armchair nanotubes with respect to different diameters are investigated. The MoS2 armchair nanotube exhibits an indirect band gap as a function of nanotube diameters from 10 Å to 50 Å, whereas MoSSe and MoSe2 exhibit a surprising diameter-induced indirect-direct band gap crossover at the diameters of 25 Å and 33 Å, respectively...
January 17, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29339964/cerebral-venous-thrombosis-with-papilloedema-secondary-to-skull-base-plasmacytoma
#9
Peter W MacIntosh, Amy Y Lin, Jin Suh Kim, Fernando D Testai, Heather E Moss
A 60-year-old woman with history of multiple myeloma was in remission after stem cell transplant 6 years prior. She was undergoing work-up for headaches that were thought to be secondary to a right mastoiditis seen on magnetic resonance imaging (MRI). On routine eye exam, papilloedema was noted. A lumbar puncture was performed, with elevated opening pressure with normal constituents. She was an atypical age for idiopathic intracranial hypertension, and her mastoiditis raised concern for secondary cerebral venous sinus thrombosis...
October 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29339958/validation-of-simplified-visual-acuity-testing-protocols-in-amyotrophic-lateral-sclerosis
#10
Lindsay C Boven, Qin Li Jiang, Heather E Moss
High- and low-contrast visual acuity (HCVA, LCVA) are potential quantitative markers of neurological dysfunction in amyotrophic lateral sclerosis (ALS). The complex nature and duration of gold standard (GS) protocols precludes widespread use in neurology settings. This study compares simplified to GS visual acuity (VA) protocols. Monocular HCVA and LCVA were measured in ALS (n = 10) and control (n = 4) subjects using six protocols, varying by two chart and three refraction methods. Intraclass correlation coefficients between simplified and GS protocols ranged from 0...
October 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29339522/effect-of-beta-agonists-on-lam-progression-and-treatment
#11
Kang Le, Wendy K Steagall, Mario Stylianou, Gustavo Pacheco-Rodriguez, Thomas N Darling, Martha Vaughan, Joel Moss
Lymphangioleiomyomatosis (LAM), a rare disease of women, is associated with cystic lung destruction resulting from the proliferation of abnormal smooth muscle-like LAM cells with mutations in the tuberous sclerosis complex (TSC) genes TSC1 and/or TSC2 The mutant genes and encoded proteins are responsible for activation of the mechanistic target of rapamycin (mTOR), which is inhibited by sirolimus (rapamycin), a drug used to treat LAM. Patients who have LAM may also be treated with bronchodilators for asthma-like symptoms due to LAM...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29339158/myosin-xi-localizes-at-the-mitotic-spindle-and-along-the-cell-plate-during-plant-cell-division-in-physcomitrella-patens
#12
Hao Sun, Fabienne Furt, Luis Vidali
Cell division is a fundamental biological process that has been extensively investigated in different systems. Similar to most eukaryotic cells, plant cells assemble a mitotic spindle to separate replicated chromosomes. In contrast, to complete cell division, plant cells assemble a phragmoplast, which is composed of aligned microtubules and actin filaments. This structure helps transport vesicles containing new cell wall material, which then fuse to form the cell plate; the cell plate will expand to create the new dividing cell wall...
January 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29337804/the-association-between-ventilator-dyssynchrony-delivered-tidal-volume-and-sedation-using-a-novel-automated-ventilator-dyssynchrony-detection-algorithm
#13
Peter D Sottile, David Albers, Carrie Higgins, Jeffery Mckeehan, Marc M Moss
OBJECTIVE: Ventilator dyssynchrony is potentially harmful to patients with or at risk for the acute respiratory distress syndrome. Automated detection of ventilator dyssynchrony from ventilator waveforms has been difficult. It is unclear if certain types of ventilator dyssynchrony deliver large tidal volumes and whether levels of sedation alter the frequency of ventilator dyssynchrony. DESIGN: A prospective observational study. SETTING: A university medical ICU...
February 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29336277/evaluation-of-hypoglycemia-and-potential-risk-factors-in-a-veterans-affairs-community-living-center
#14
Marissa L Ostroff, Kristin Aloi, William Bryan, Jason Moss, Lindsay Garris, Richard Sloane, Jennie Hewitt, Carrie Thomas, Janine Bailey
OBJECTIVES: To describe hypoglycemic events in a Veterans Affairs (VA) community living center (CLC) population and to determine predictive risk factors associated with hypoglycemia. DESIGN: Retrospective, exploratory, observational chart review. SETTING: Tertiary-care VA Healthcare System CLC. PATIENTS: Residents residing in a VA CLC with at least one active order for insulin between June 1, 2009, and June 30, 2013, were evaluated over a 90-day study period...
January 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29335590/direct-observation-of-the-effects-of-cellulose-synthesis-inhibitors-using-live-cell-imaging-of-cellulose-synthase-cesa-in-physcomitrella-patens
#15
Mai L Tran, Thomas W McCarthy, Hao Sun, Shu-Zon Wu, Joanna H Norris, Magdalena Bezanilla, Luis Vidali, Charles T Anderson, Alison W Roberts
Results from live cell imaging of fluorescently tagged Cellulose Synthase (CESA) proteins in Cellulose Synthesis Complexes (CSCs) have enhanced our understanding of cellulose biosynthesis, including the mechanisms of action of cellulose synthesis inhibitors. However, this method has been applied only in Arabidopsis thaliana and Brachypodium distachyon thus far. Results from freeze fracture electron microscopy of protonemal filaments of the moss Funaria hygrometrica indicate that a cellulose synthesis inhibitor, 2,6-dichlorobenzonitrile (DCB), fragments CSCs and clears them from the plasma membrane...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29335336/periodontal-disease-regular-dental-care-use-and-incident-ischemic-stroke
#16
Souvik Sen, Lauren D Giamberardino, Kevin Moss, Thiago Morelli, Wayne D Rosamond, Rebecca F Gottesman, James Beck, Steven Offenbacher
BACKGROUND AND PURPOSE: Periodontal disease is independently associated with cardiovascular disease. Identification of periodontal disease as a risk factor for incident ischemic stroke raises the possibility that regular dental care utilization may reduce the stroke risk. METHODS: In the ARIC (Atherosclerosis Risk in Communities) study, pattern of dental visits were classified as regular or episodic dental care users. In the ancillary dental ARIC study, selected subjects from ARIC underwent fullmouth periodontal measurements collected at 6 sites per tooth and classified into 7 periodontal profile classes (PPCs)...
January 15, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29333655/preparation-of-high-percentage-1t-phase-transition-metal-dichalcogenide-nanodots-for-electrochemical-hydrogen-evolution
#17
Chaoliang Tan, Zhimin Luo, Apoorva Chaturvedi, Yongqing Cai, Yonghua Du, Yue Gong, Ying Huang, Zhuangchai Lai, Xiao Zhang, Lirong Zheng, Xiaoying Qi, Min Hao Goh, Jie Wang, Shikui Han, Xue-Jun Wu, Lin Gu, Christian Kloc, Hua Zhang
Nanostructured transition metal dichalcogenides (TMDs) are proven to be efficient and robust earth-abundant electrocatalysts to potentially replace precious platinum-based catalysts for the hydrogen evolution reaction (HER). However, the catalytic efficiency of reported TMD catalysts is still limited by their low-density active sites, low conductivity, and/or uncleaned surface. Herein, a general and facile method is reported for high-yield, large-scale production of water-dispersed, ultrasmall-sized, high-percentage 1T-phase, single-layer TMD nanodots with high-density active edge sites and clean surface, including MoS2 , WS2 , MoSe2 , Mo0...
January 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29332625/positive-and-negative-affect-mediate-the-bidirectional-relationship-between-emotional-processing-and-symptom-severity-and-impact-in-irritable-bowel-syndrome
#18
Alice Sibelli, Trudie Chalder, Hazel Everitt, Joseph Chilcot, Rona Moss-Morris
INTRODUCTION: Individuals with IBS report higher levels of psychological distress compared to healthy controls. Distress has been associated with emotional processing difficulties but studies have not explored how the relationship between distress and emotional processing affects IBS. There is little research on the role of positive affect (PA) in IBS. AIMS: (a) If difficulties in self-reported emotional processing are associated with affect and IBS measures (i...
February 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29329513/the-behavioural-phenotype-of-potocki-lupski-syndrome-a-cross-syndrome-comparison
#19
Stacey Bissell, Lucy Wilde, Caroline Richards, Jo Moss, Chris Oliver
BACKGROUND: Potocki-Lupski syndrome (PTLS) and Smith-Magenis syndrome (SMS) are related genomic disorders, as duplication 17p11.2 (associated with PTLS) is the reciprocal recombination product of the SMS microdeletion. While SMS has a relatively well-delineated behavioural phenotype, the behavioural profile in PTLS is less well defined, despite purported associations with autism spectrum disorder (ASD) and the suggestion that some behaviours may be diametric to those seen in SMS. METHODS: Caregivers of individuals with PTLS (N = 34; M age = 12...
January 10, 2018: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/29327623/pussy-riot-commentary-on-hansbury
#20
Donald Moss
No abstract text is available yet for this article.
December 2017: Journal of the American Psychoanalytic Association
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