Jeffrey S Phillips, Nagesh Adluru, Moo K Chung, Hamsanandini Radhakrishnan, Christopher A Olm, Philip A Cook, James C Gee, Katheryn A Q Cousins, Sanaz Arezoumandan, David A Wolk, Corey T McMillan, Murray Grossman, David J Irwin
INTRODUCTION: Multimodal evidence indicates Alzheimer's disease (AD) is characterized by early white matter (WM) changes that precede overt cognitive impairment. WM changes have overwhelmingly been investigated in typical, amnestic mild cognitive impairment and AD; fewer studies have addressed WM change in atypical, non-amnestic syndromes. We hypothesized each non-amnestic AD syndrome would exhibit WM differences from amnestic and other non-amnestic syndromes. MATERIALS AND METHODS: Participants included 45 cognitively normal (CN) individuals; 41 amnestic AD patients; and 67 patients with non-amnestic AD syndromes including logopenic-variant primary progressive aphasia (lvPPA, n = 32), posterior cortical atrophy (PCA, n = 17), behavioral variant AD (bvAD, n = 10), and corticobasal syndrome (CBS, n = 8)...
2024: Frontiers in Neuroscience