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https://www.readbyqxmd.com/read/29772037/a-review-of-fabry-disease
#1
A Cinats, E Heck
The class of medications known as Janus kinase inhibitors block cytokine-mediated signaling via the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway, which plays an important role in immunoregulation and normal cell growth. This class includes the drugs tofacitinib, approved for the treatment of rheumatoid arthritis, and ruxolitinib, approved for the treatment of myelofibrosis and polycythemia rubra vera. The most common adverse events (AEs) reported in patients taking tofacitinib are infections, whereas the most common AEs in patients taking ruxolitinib are anemia and thrombocytopenia...
May 2018: Skin Therapy Letter
https://www.readbyqxmd.com/read/29771216/mindfulness-based-cognitive-hypnotherapy-and-skin-disorders
#2
Philip D Shenefelt
Mindfulness-based cognitive hypnotherapy integrates mindfulness, cognitive-behavioral therapy, and hypnotherapy to improve physical, emotional, mental, and/or spiritual aspects of skin disorders. Meditation, including mindfulness meditation, and hypnosis both utilize trance phenomena to help produce focalization and specific improvements in skin disorders through psycho-neuro-endocrine-immunologic mechanisms. Hypnosis, cognitive hypnotherapy, focused meditation, and mindfulness meditation are discussed with respect to improving various skin disorders including acne, acne excoriée, alopecia areata, atopic dermatitis, congenital ichthyosiform erythroderma, dyshidrotic dermatitis, erythema nodosum, erythromelalgia, furuncles, glossodynia, herpes simplex, hyperhidrosis, ichthyosis vulgaris, lichen planus, neurodermatitis, nummular dermatitis, postherpetic neuralgia, prurigo nodularis, pruritus, psoriasis, rosacea, trichotillomania, urticaria, verruca vulgaris, and vitiligo...
July 2018: American Journal of Clinical Hypnosis
https://www.readbyqxmd.com/read/29769782/graft-versus-host-disease-presenting-as-fibrosing-alopecia-in-a-pattern-distribution-a-model-for-pathophysiological-understanding-of-cicatricial-pattern-hair-loss
#3
Hudson Dutra Rezende, Maria Fernanda Reis Gavazzoni Dias, Ralph Michel Trüeb
A case of cutaneous graft versus host disease (GvHD) presenting as fibrosing alopecia in a pattern distribution (FAPD) is discussed, possibly providing a mechanistic model for a better understanding of the pathogenic events underlying cicatricial pattern hair loss. The implication of a follicular inflammation and fibrosis associated with patterned hair loss has emerged from several independent studies. Eventually, Zinkernagel and Trüeb reported a peculiar type of cicatricial pattern hair loss with histopathological features consistent with lichen planopilaris (LPP) associated with androgenetic alopecia (AGA)...
March 2018: International Journal of Trichology
https://www.readbyqxmd.com/read/29768073/an-open-label-non-randomized-prospective-pilot-study-of-the-efficacy-of-q-switched-nd-yag-laser-in-management-of-facial-lichen-planus-pigmentosus
#4
Dr Swapnil Deepak Shah, Dr Sanjeev Aurangabadkar, Dr Balkrishna Nikam
Lichen planus pigmentosus (LPP) is a cosmetically disfiguring condition. Many treatment options are available which are effective in halting the progression of the disease. The treatment of persistent pigmentation is still a challenge. We describe the use of Q-switched Nd-YAG laser in 13 patients with stable LPP using a standard protocol. Most of our patients showed complete to near-complete resolution of pigment without much complications.
May 16, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29765970/clinical-description-of-frontal-fibrosing-alopecia-with-concomitant-lichen-planopilaris
#5
David Saceda-Corralo, Pablo Fernández-Crehuet, Pablo Fonda-Pascual, Cristina Pindado-Ortega, Oscar M Moreno-Arrones, Sergio Vañó-Galván
No abstract text is available yet for this article.
April 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29765960/lichen-planopilaris-with-pustules-a-diagnostic-challenge
#6
Karina L Morais, Cintia F Martins, Alessandra Anzai, Neusa Y S Valente, Ricardo Romiti
Introduction: Lichen planopilaris (LPP) is a lymphocytic primary cicatricial alopecia presenting with scarring hair loss and variable degrees of perifollicular erythema and scaling. Pustules are infrequent and may mimic folliculitis decalvans (FD) and other forms of neutrophilic alopecia. We present a series of LPP cases with pustules and discuss the importance of differentiating them from primary neutrophilic folliculitis. Materials and Methods: Demographic, clinical, histopathological, and follow-up data of 13 cases of LPP with pustules followed at the Department of Dermatology of the University of São Paulo Medical School were described...
April 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29763879/plant-and-vegetation-functional-responses-to-cumulative-high-nitrogen-deposition-in-rear-edge-heathlands
#7
Angela Taboada, Javier Calvo-Fernández, Elena Marcos, Leonor Calvo
Elevated atmospheric nitrogen (N) deposition is a major driver of change, altering the structure/functioning of nutrient-poor Calluna vulgaris-heathlands over Europe. These effects amply proven for north-western/central heathlands may, however, vary across the ecosystem's distribution, especially at the range limits, as heathlands are highly vulnerable to land-use changes combined with present climate change. This is an often overlooked and greatly understudied aspect of the ecology of heathlands facing global change...
May 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29761782/-vulvar-intraepithelial-neoplasia
#8
Signe Østergård, Christina Steen Vorbeck, Mette Meinert
Vulvar intraepithelial neoplasia (VIN) is a rare but premalig-nant condition. VIN has two aetiological pathways: a human papillomavirus (HPV)-dependent pathway, which is a vulvar high-grade squamous intraepithelial lesion (HSIL), and an HPV-independent pathway, called differentiated VIN (d-VIN), associated with lichen sclerosus. d-VIN is more aggressive than vulvar HSIL. In case of symptoms, a biopsy should be performed. The recurrence risk is high: 25-50% regardless of treatment type. We recommend treatment with imiquimod as first choice to avoid mutilating surgery...
May 14, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29761320/strong-specificity-and-network-modularity-at-a-very-fine-phylogenetic-scale-in-the-lichen-genus-peltigera
#9
P L Chagnon, N Magain, J Miadlikowska, F Lutzoni
Identifying the drivers and evolutionary consequences of species interactions is a major goal of community ecology. Network-based analyses can provide mathematical tools to detect non-random patterns of interactions, and potentially help predicting the consequences of such patterns on evolutionary dynamics of symbiotic systems. Here, we characterize the structure of a lichen network at a very fine phylogenetic scale, by identifying the photosynthetic partners (i.e., cyanobacteria of the genus Nostoc) of lichenized fungi belonging to a monophyletic section of a single genus (i...
May 14, 2018: Oecologia
https://www.readbyqxmd.com/read/29760823/comment-on-xerostomia-and-salivary-gland-hypofunction-in-patients-with-oral-lichen-planus-before-and-after-treatment-with-topical-corticosteroids
#10
Mahdieh-Sadat Moosavi, Hoda Barati
No abstract text is available yet for this article.
2018: Open Dentistry Journal
https://www.readbyqxmd.com/read/29760622/skin-and-mucous-membranes-manifestations-of-dermatological-diseases-within-the-genital-area-in-females
#11
Katarzyna Plagens-Rotman, Renata Przybylska, Zygmunt Adamski, Magdalena Czarnecka-Operacz
Introduction: Lichen sclerosus et atrophicus (LSA) and an inversed type of psoriasis belong to a group of benign dermatoses usually located within the region of female external genitalia. The most common subjective symptoms reported by patients are itching, pain and changes in the color and structure of the skin. Aim: This paper presents 3 cases of patients suffering from selected dermatoses located within the external female genitalia treated at the Department of Dermatology, Poznan University of Medical Sciences...
April 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29757849/ocular-surface-findings-in-patients-with-lichen-planopilaris
#12
Mehdi Gheisari, Sahar Dadkhahfar, Kaveh Fadakar, Reza Mahmoud Robati, Hamideh Moravvej, Mohammad Soleimani, Reza Mirshahi
PURPOSE: Lichen planopilaris (LPP) is a chronic lymphocytic- mediated disorder that selectively involves hair follicles, leading to cicatricial alopecia. The eyelash follicle and meibomian gland (MG) might also be involved in the disease process leading to ocular surface problems. METHODS: In this Cross-sectional case -control study, twenty-three patients with histologically confirmed LPP and 23 healthy controls were recruited in this controlled study. To quantify the signs and symptoms of LPP, we used the Lichen Planopilaris Activity Index...
May 10, 2018: Cornea
https://www.readbyqxmd.com/read/29755563/anti-mutagenic-and-anti-oxidant-potencies-of-cetraria-aculeata-schreb-fr-cladonia-chlorophaea-fl%C3%A3-rke-ex-sommerf-spreng-and-cetrelia-olivetorum-nyl-w-l-culb-c-f-culb
#13
Selcuk Ceker, Furkan Orhan, Selma Sezen, Medine Gulluce, Hakan Ozkan, Ali Aslan, Güleray Agar
In this study, the mutagenic and anti-mutagenic effects of methanol extract of three lichen species ( Cetraria aculeata , Cladonia chlorophaea and Cetrelia olivetorum ) were investigated by using E. coli- WP2, Ames-Salmonella (TA1535 and TA1537) and sister chromatid exchange (SCE) test systems. The results obtained from bacterial test systems demonstrated that methanol extracts of three lichen species have strong anti-mutagenic potencies on TA1535, TA1537 strains and to a lesser extent on E. coli -WP2 strain...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29754454/heparinoid-suppresses-der-p-induced-il-1%C3%AE-production-by-inhibiting-erk-and-p38-mapk-pathways-in-keratinocytes
#14
Ryo Utsunomiya, Xiuju Dai, Masamoto Murakami, Hidenori Okazaki, Teruko Tsuda, Hideki Mori, Ken Shiraishi, Mikiko Tohyama, Koji Sayama
Epidermal keratinocytes initiate skin inflammation by activating immune cells. The skin barrier is disrupted in atopic dermatitis (AD) and epidermal keratinocytes can be exposed to environmental stimuli, such as house dust mite (HDM) allergens. We showed previously that HDM allergens activate the NLRP3 inflammasome of keratinocytes, thereby releasing pro-inflammatory cytokines. Heparinoid is an effective moisturizer for atopic dry skin. However, a recent report showed that heparinoid treatment can improve inflammation of lichen planus...
May 13, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29753458/gastric-parietal-cell-and-thyroid-autoantibodies-in-recurrent-aphthous-stomatitis-patients-with-concomitant-oral-lichen-planus
#15
Yang-Che Wu, Julia Yu-Fong Chang, Yi-Ping Wang, Yu-Hsueh Wu, Hsin-Ming Chen, Andy Sun
BACKGROUND/PURPOSE: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) have not yet been reported in recurrent aphthous stomatitis (RAS) patients with concomitant oral lichen planus (OLP/RAS patients). This study mainly assessed the frequencies of serum GPCA, TGA, and TMA (GPCA/TGA/TMA) positivities in 44 OLP/RAS patients. METHODS: The frequencies of serum GPCA/TGA/TMA positivities in 44 OLP/RAS patients, OLP/RAS patients of four different subgroups, 520 RAS patients, and 352 healthy control subjects were calculated and compared...
May 9, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29752105/usnic-acid-loaded-polyaniline-polyurethane-foam-wound-dressing-preparation-and-bactericidal-activity
#16
Marcelo R Dos Santos, Jose J Alcaraz-Espinoza, Mateus M da Costa, Helinando P de Oliveira
The improved bactericidal activity of new composites for wound dressing prototypes represents an important strategy for development of more efficient devices that make use of synergistic interaction between components. The doping level of polyaniline represents a critical parameter for its corresponding biologic activity. In this work, it is explored the doping effect of usnic acid on undoped polyaniline, that introduces important advantages namely, improved bactericidal activity of polyaniline and the anti-biofilm properties of lichen derivative...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29750709/classic-vulvar-intraepithelial-neoplasia-with-superimposed-lichen-simplex-chronicus-a-unique-variant-mimicking-differentiated-vulvar-intraepithelial-neoplasia
#17
Jaclyn C Watkins, Eric Yang, Christopher P Crum, Michael Herfs, Tarik Gheit, Massimo Tommasino, Marisa R Nucci
High-grade vulvar intraepithelial neoplasia, a precursor lesion to vulvar squamous cell carcinoma, is subdivided into 2 types, classic or usual vulvar intraepithelial neoplasia (CVIN) and differentiated vulvar intraepithelial neoplasia (DVIN). CVIN, which is a human papilloma virus (HPV)-dependent lesion, is typically distinguished from DVIN, a p53 mutation-dependent process, by its distinct histomorphologic and immunohistochemical characteristics. However, distinguishing between the 2 entities becomes challenging in cases of CVIN with superimposed inflammatory changes, especially lichen simplex chronicus (LSC)...
May 10, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29744205/serum-cytokine-profile-and-clinicopathological-findings-in-oral-lichen-planus-oral-lichenoid-lesions-and-stomatitis
#18
Kristine Roen Larsen, Jeanne Duus Johansen, Jesper Reibel, Claus Zachariae, Anne Marie Lynge Pedersen
The objective of this study was to examine if clinical and histopathological variables in patients with oral lichen planus (OLP), oral lichenoid lesions (OLL), and generalized stomatitis display different cytokine profiles and if concomitant contact allergy influences this profile. Forty-nine patients and 29 healthy age- and gender-matched subjects were included. Demographic and clinical data immunohistochemical findings in mucosal specimens, results of contact allergy testing, and serum levels of tumor necrosis factor-α, interferon-γ, interleukin (IL)-6, IL-10, IL-12p40, and IL-12p70 were analyzed and compared between groups...
December 2017: Clinical and Experimental Dental Research
https://www.readbyqxmd.com/read/29738106/rate-of-malignant-transformation-of-oral-lichen-planus-a-systematic-review
#19
REVIEW
Michele Giuliani, Giuseppe Troiano, Massimo Cordaro, Massimo Corsalini, Gioele Gioco, Lorenzo Lo Muzio, Pamela Pignatelli, Carlo Lajolo
OBJECTIVE: The aim of this study is to systematically review the literature to determine: 1) the malignant transformation rate (TR) of Oral Lichen Planus (OLP) and its risk factors; 2) whether or not Oral Lichenoid Lesions (OLL) have a different malignant TR. MATERIALS AND METHODS: PubMed, Scopus and Web of Science were used as search engines: only observational, full-length, English language studies were investigated. PRISMA protocol was used to evaluate and present results...
May 8, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29733371/enforced-fungal-algal-symbioses-in-alginate-spheres
#20
Lucia Muggia, Sigrun Kraker, Theodora Gößler, Martin Grube
The thallus structure of the lichen symbiosis provides a fungal shelter for the growth of algal partners. The long-living thallus also provides a habitat for other fungi, but experimental studies, which could inform us about the details of their interactions have hardly been conducted. We present a new approach by embedding axenically cultured strains of fungi together with algae in alginate spheres, which allows easy transfer of co-cultures on solid media. As the growth rates of the organisms are differentially triggered by the underlying medium, alginate embedding can help to adjust optimal parameters for stable culture of the combined symbionts...
May 4, 2018: FEMS Microbiology Letters
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