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https://www.readbyqxmd.com/read/28737238/the-possible-role-of-human-papillomavirus-infection-in-the-development-of-lichen-sclerosus
#1
REVIEW
Anna K Hald, Jan Blaakaer
Lichen sclerosus (LS) is a chronic inflammatory skin disease of unknown origin predominantly affecting the anogenital area that causes pruritus and pain and is associated with an increased risk of malignancy. In some cases, LS vanishes after application of imiquimod, raising the question whether human papillomavirus (HPV) may have an etiopathogenic role in anogenital LS. The databases MEDLINE and Embase were systematically searched using the PRISMA guidelines. Twenty-seven papers were included that reported the prevalence of HPV in LS and in LS associated with neoplasia...
July 24, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28736865/bioprotection-of-the-built-environment-and-cultural-heritage
#2
Geoffrey Michael Gadd, Thomas D Dyer
The growth of microbial biofilms and various biomineralization phenomena can lead to the formation of stable layers and veneers on rocks known as 'rock varnishes' that can stabilize surfaces and protect from further weathering. This article describes the potential application of fungal systems for bioprotection of rock and mineral-based substrates and the evidence to support this concept of utilizing natural or engineered colonization and metabolic properties of fungi, including lichens.
July 24, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28736812/hair-transplantation-for-the-treatment-of-lichen-planopilaris-and-frontal-fibrosing-alopecia-a-report-of-two-cases
#3
You-Chen Serena Liu, Shiou-Hwa Jee, Jung-Yi Lisa Chan
The efficacy of current medical treatments for lichen planopilaris (LPP) and its variant, frontal fibrosing alopecia (FFA), both lymphocyte-mediated primary cicatricial alopecias, is limited. Hair regrowth from scar tissue is usually not possible. Although hair transplantation restores the hairline and increases hair density in patients with cicatricial alopecia, the timing of the transplantation is crucial. Here, we report two Chinese patients with LPP or FFA who underwent the follicular unit extraction method of hair transplantation after the diseases were stabilised with therapy, with satisfactory results for 3-4 years of follow up...
July 24, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28736072/antibacterial-activities-of-natural-lichen-compounds-against-streptococcus-gordonii-and-porphyromonas-gingivalis
#4
Alaa Sweidan, Marylene Chollet-Krugler, Aurelie Sauvager, Pierre van de Weghe, Ali Chokr, Martine Bonnaure-Mallet, Sophie Tomasi, Latifa Bousarghin
The oral bacteria not only infect the mouth and reside there, but also travel through the blood and reach distant body organs. If left untreated, the dental biofilm that can cause destructive inflammation in the oral cavity may result in serious medical complications. In dental biofilm, Streptococcus gordonii, a primary oral colonizer, constitutes the platform on which late pathogenic colonizers like Porphyromonas gingivalis, the causative agent of periodontal diseases, will bind. The aim of this study was to determine the antibacterial activity of eleven natural lichen compounds belonging to different chemical families and spanning from linear into cyclic and aromatic structures to uncover new antibiotics which can fight against the oral bacteria...
July 20, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28733648/modulation-of-polypeptide-conformation-through-donor-acceptor-transformation-of-side-chain-hydrogen-bonding-ligands
#5
Ziyuan Song, Rachael A Mansbach, Hua He, Kuo-Chih Shih, Ryan Baumgartner, Nan Zheng, Xiaochu Ba, Yinzhao Huang, Deepak Mani, Yun Liu, Yao Lin, Mu-Ping Nieh, Andrew L Ferguson, Lichen Yin, Jianjun Cheng
Synthetic polypeptides have received increasing attention due to their ability to form higher ordered structures similar to proteins. The control over their secondary structures, which enables dynamic conformational changes, is primarily accomplished by tuning the side-chain hydrophobic or ionic interactions. Herein we report a strategy to modulate the conformation of polypeptides utilizing donor-acceptor interactions emanating from side-chain H-bonding ligands. Specifically, 1,2,3-triazole groups, when incorporated onto polypeptide side-chains, serve as both H-bond donors and acceptors at neutral pH and disrupt the α-helical conformation...
July 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28732699/triggers-of-oral-lichen-planus-flares-and-the-potential-role-of-trigger-avoidance-in-disease-management
#6
Hannah X Chen, Rachel Blasiak, Edwin Kim, Ricardo Padilla, Donna A Culton
OBJECTIVE: Many patients with oral lichen planus (OLP) report triggers of flares, some of which overlap with triggers of other oral diseases, including oral allergy syndrome and oral contact dermatitis. The purpose of this study was to evaluate the prevalence of commonly reported triggers of OLP flares, their overlap with triggers of other oral diseases, and the potential role of trigger avoidance as a management strategy. STUDY DESIGN: Questionnaire-based survey of 51 patients with biopsy-proven lichen planus with oral involvement seen in an academic dermatology specialty clinic and/or oral pathology clinic between June 2014 and June 2015...
May 30, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28726494/roccellatol-a-new-%C3%AE-orcinol-based-metabolite-from-the-lichen-roccella-montagnei
#7
Uppuluri V Mallavadhani, Akella V S Sudhakar
Roccellatol, a new (2'R,3'S)-erythrityl-2,6-dihydroxy-4-methylbenzoate was isolated along with nine known compounds from the fruticose lichen, Roccella montagnei Bel. em. D.D. Awasthi. The structure of the new compound was elucidated by detailed spectroscopic analysis ((1)H, (13)C, DEPT and HRMS). The present isolation of roccellatol (10) assumes significance as the esters of p-orcellinic acid are rare in lichens. Interestingly, among the known compounds, (+)-montagnetol (9) was now isolated in very large quantity (4...
July 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28725228/unraveling-the-photoprotective-response-of-lichenized-and-free-living-green-algae-trebouxiophyceae-chlorophyta-to-photochilling-stress
#8
Fátima Míguez, Ulf Schiefelbein, Ulf Karsten, José I García-Plazaola, Lydia Gustavs
Lichens and free-living terrestrial algae are widespread across many habitats and develop successfully in ecosystems where a cold winter limits survival. With the goal of comparing photoprotective responses in free-living and lichenized algae, the physiological responses to chilling and photochilling conditions were studied in three lichens and their isolated algal photobionts together as well as in a fourth free-living algal species. We specifically addressed the following questions: (i) Are there general patterns of acclimation in green algae under chilling and photochilling stresses? (ii) Do free-living algae exhibit a similar pattern of responses as their lichenized counterparts? (iii) Are these responses influenced by the selection pressure of environmental conditions or by the phylogenetic position of each species? To answer these questions, photosynthetic fluorescence measurements as well as pigment and low molecular weight carbohydrate pool analyses were performed under controlled laboratory conditions...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28724401/deciphering-functional-diversification-within-the-lichen-microbiota-by-meta-omics
#9
Tomislav Cernava, Armin Erlacher, Ines Aline Aschenbrenner, Lisa Krug, Christian Lassek, Katharina Riedel, Martin Grube, Gabriele Berg
BACKGROUND: Recent evidence of specific bacterial communities extended the traditional concept of fungal-algal lichen symbioses by a further organismal kingdom. Although functional roles were already assigned to dominant members of the highly diversified microbiota, a substantial fraction of the ubiquitous colonizers remained unexplored. We employed a multi-omics approach to further characterize functional guilds in an unconventional model system. RESULTS: The general community structure of the lichen-associated microbiota was shown to be highly similar irrespective of the employed omics approach...
July 19, 2017: Microbiome
https://www.readbyqxmd.com/read/28717240/elemental-compositions-of-lichens-from-duolun-county-inner-mongolia-china-origin-road-effect-and-species-difference
#10
Hua-Jie Liu, Jing-Gong Wang, Yu Xia, Meng-Jie Yang, Si-Wa Liu, Liang-Cheng Zhao, Xiu-Ping Guo, Yun-Jun Jiang, Xin Li, Qing-Feng Wu, Shi-Bo Fang
To assess the response of lichen elemental compositions to road traffic and species difference in the context of high dust input and anthropogenic emissions, two foliose epiphytic lichens (Phaeophyscia hirtuosa, PHh; Candelaria fibrosa, CAf) were sampled near a road adjacent to Dolon Nor Town (Duolun County, Inner Mongolia, China). Twenty elements (Ba, Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Mo, Na, Ni, P, Pb, Sb, Sr, Ti, V and Zn) in lichen and surface soil samples were analysed using inductively coupled plasma mass spectrometer (ICP-MS)...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716436/frontal-fibrosing-alopecia-among-men-a%C3%A2-clinicopathologic-study-of-7-cases
#11
Stanislav N Tolkachjov, Hafsa M Chaudhry, Michael J Camilleri, Rochelle R Torgerson
BACKGROUND: Frontal fibrosing alopecia (FFA) is a lichen planopilaris-variant scarring alopecia that has rarely been described in men. OBJECTIVE: To characterize the clinicopathologic findings of FFA in men by studying a series of 7 male patients. METHODS: We conducted a retrospective review of all cases of male patients with FFA at the Mayo Clinic from 1992 to 2016. RESULTS: Seven male patients with FFA were identified...
July 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28712412/the-relationship-between-levels-of-salivary-and-serum-interleukin-6-and-oral-lichen-planus-a-systematic-review-and-meta-analysis
#12
REVIEW
Jinglong Liu, Quan Shi, Shuo Yang, Qianxin Wang, Juan Xu, Bin Guo
BACKGROUND: The relationship between levels of salivary and serum interleukin (IL)-6 and oral lichen planus (OLP) is not understood fully. The authors conducted a systematic review and meta-analysis to compare levels of salivary and serum IL-6 among people with OLP and healthy control participants. METHODS: The authors searched the literature for studies whose investigators had evaluated the relationships between IL-6 and OLP before treatment. The authors used meta-analysis to compare the standardized mean differences (SMD) of the levels of salivary and serum IL-6 between people who had OLP and people who did not have OLP and between patients with erosive OLP and patients with nonerosive OLP...
July 13, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28711823/using-nitrogen-concentration-and-isotopic-composition-in-lichens-to-spatially-assess-the-relative-contribution-of-atmospheric-nitrogen-sources-in-complex-landscapes
#13
P Pinho, C Barros, S Augusto, M J Pereira, C Máguas, C Branquinho
Reactive nitrogen (Nr) is an important driver of global change, causing alterations in ecosystem biodiversity and functionality. Environmental assessments require monitoring the emission and deposition of both the amount and types of Nr. This is especially important in heterogeneous landscapes, as different land-cover types emit particular forms of Nr to the atmosphere, which can impact ecosystems distinctively. Such assessments require high spatial resolution maps that also integrate temporal variations, and can only be feasibly achieved by using ecological indicators...
July 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28706561/automatic-detection-of-epilepsy-and-seizure-using-multiclass-sparse-extreme-learning-machine-classification
#14
Yuanfa Wang, Zunchao Li, Lichen Feng, Chuang Zheng, Wenhao Zhang
An automatic detection system for distinguishing normal, ictal, and interictal electroencephalogram (EEG) signals is of great help in clinical practice. This paper presents a three-class classification system based on discrete wavelet transform (DWT) and the nonlinear sparse extreme learning machine (SELM) for epilepsy and epileptic seizure detection. Three-level lifting DWT using Daubechies order 4 wavelet is introduced to decompose EEG signals into delta, theta, alpha, and beta subbands. Considering classification accuracy and computational complexity, the maximum and standard deviation values of each subband are computed to create an eight-dimensional feature vector...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28706407/incidence-of-oral-lichen-planus-in-perimenopausal-women-a-cross-sectional-study-in-western-uttar-pradesh-population
#15
Ravi Prakash Sasankoti Mohan, Akanksha Gupta, Nagaraju Kamarthi, Sangeeta Malik, Sumit Goel, Swati Gupta
BACKGROUND: Hormonal fluctuations during menopause lead to endocrine changes in women, especially in their sex steroid hormone production. Studies have documented the role of estrogen and progesterone (Pg) on autoimmune disorders such as multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis. Lichen planus (LP), an autoimmune disorder, seen frequently in perimenopausal women, may also get affected by sex steroid hormones, but no direct relationship has been established yet...
April 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28706405/vulvar-lichen-sclerosus-et-atrophicus
#16
REVIEW
Pragya Ashok Nair
Vulvar lichen sclerosus (VLS) is a chronic inflammatory dermatosis characterized by ivory-white plaques or patches with glistening surface commonly affecting the vulva and anus. Common symptoms are irritation, soreness, dyspareunia, dysuria, and urinary or fecal incontinence. Anogenital lichen sclerosus (LS) is characterized by porcelain-white atrophic plaques, which may become confluent extending around the vulval and perianal skin in a figure of eight configuration. Thinning and shrinkage of the genital area make coitus, urination, and defecation painful...
April 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28705517/lichen-aureus-a-congenital-case
#17
O Corral Magaña, J Escalas Taberner, A Bauzá Alonso, A Martin-Santiago
No abstract text is available yet for this article.
July 11, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28705509/cytochalasin-e-in-the-lichen-pleurosticta-acetabulum-anti-proliferative-activity-against-human-ht-29-colorectal-cancer-cells-and-quantitative-variability
#18
Sylvie Delebassée, Lengo Mambu, Emilie Pinault, Yves Champavier, Bertrand Liagre, Marion Millot
A biological screening of sixteen lichen extracts on human HT-29 colorectal cancer cells, led to the selection of Pleurosticta acetabulum, a lichen widely present in tree barks in Europe. Bioguided purification of the acetonic extract resulted in the isolation of cytochalasin E, a common fungal metabolite. This compound is responsible for the anti-proliferative activity of the extract. Its presence in lichens is reported here for the first time. LC-MS quantitation of cytochalasin E in different samples of P...
July 10, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28705287/generalized-discoid-lupus-erythematosus-as-the-presenting-sign-of-small-cell-lung-carcinoma
#19
Tania M Gonzalez Santiago, David A Wetter, Garrett C Lowe, Gabriel F Sciallis
A 46-year-old woman with a 30 pack-year smoking history presented with a worsening eruption on the left cheek that failed to improve with metronidazole gel. The cutaneous eruption spread to most of her face and did not respond to a brief tapering course of prednisone. During the initial evaluation at our institution, approximately 6 weeks after the onset of the cutaneous eruption, the patient had erythematous, crusted plaques on her face and scalp (Figure 1A); they were also present on the V-area of the anterior aspect of the neck and upper region of the chest, the shoulders, and the arms, with isolated lesions on the trunk and legs...
2017: Skinmed
https://www.readbyqxmd.com/read/28704942/specialized-metabolites-of-the-lichen-vulpicida-pinastri-act-as-photoprotective-agents
#20
Béatrice Legouin, Françoise Lohézic-Le Dévéhat, Solenn Ferron, Isabelle Rouaud, Pierre Le Pogam, Laurence Cornevin, Michel Bertrand, Joël Boustie
The extreme resiliency of lichens to UV radiations makes them an interesting model to find new photoprotective agents acting as UV-blockers and antioxidant. In this research, using a new in vitro method designed to overcome the shortage of material associated to many studies dealing with natural products, we show that the three major compounds isolated from the lichen Vulpicida pinastri, vulpinic acid, pinastric acid and usnic acid, were UV blocker agents. Antioxidant assays evidenced superoxide anion scavenging activity...
July 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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