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Dyspepsia

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https://www.readbyqxmd.com/read/28913872/high-primary-antibiotic-resistance-of-helicobacter-pylori-strains-isolated-from-dyspeptic-patients-a-prevalence-cross-sectional-study-in-spain
#1
Fernando Macías-García, José Llovo-Taboada, Mario Díaz-López, Iria Bastón-Rey, Juan Enrique Domínguez-Muñoz
BACKGROUND: The rate of H. pylori resistance to different antibiotics is increasing and determines the selection of eradication therapy. The aim of this study was to determine the resistance patterns of H. pylori strains in our area. METHODS: Biopsies from gastric corpus for microbiological culture and antibiotic resistance were obtained in patients undergoing upper gastrointestinal endoscopy for dyspepsia. Selective Agar Pylori for isolation of the bacteria and Agar Mueller-Hinton supplemented with blood to test the sensitivity to antibiotics were used...
September 15, 2017: Helicobacter
https://www.readbyqxmd.com/read/28913843/food-and-functional-dyspepsia-a-systematic-review
#2
REVIEW
K R Duncanson, N J Talley, M M Walker, T L Burrows
BACKGROUND: Functional dyspepsia (FD) is a debilitating functional gastrointestinal disorder characterised by early satiety, post-prandial fullness or epigastric pain related to meals, which affects up to 20% of western populations. A high dietary fat intake has been linked to FD and duodenal eosinophilia has been noted in FD. We hypothesised that an allergen such as wheat is a risk factor for FD and that withdrawal will improve symptoms of FD. We aimed to investigate the relationship between food and functional dyspepsia...
September 15, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28913777/diabetes-and-the-small-intestine
#3
REVIEW
Jonathan Gotfried, Stephen Priest, Ron Schey
Diabetes mellitus (DM) and its associated complications are becoming increasingly prevalent. Gastrointestinal symptoms associated with diabetes is known as diabetic enteropathy (DE) and may manifest as either diarrhea, fecal incontinence, constipation, dyspepsia, nausea, and vomiting or a combination of symptoms. The long-held belief that vagal autonomic neuropathy is the primary cause of DE has recently been challenged by newer theories of disease development. Specifically, hyperglycemia and the resulting oxidative stress on neural networks, including the nitrergic neurons and interstitial cells of Cajal (ICC), are now believed to play a central role in the development of DE...
September 15, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28912900/open-label-trial-of-the-efficacy-and-safety-profile-of-rikkunshito-used-for-the-treatment-of-gastrointestinal-symptoms-in-patients-with-parkinson-s-disease-a-pilot-study
#4
Koji Yakabi, Naomi Yamaguchi, Shino Ono, Norihito Yoshida, Eriko Hosomi, Kenjiro Hayashi, Mitsuko Ochiai, Kosuke Maezawa, Kyoichi Nomura
BACKGROUND: Patients with Parkinson's disease (PD) usually experience distress related not only to motor dysfunction, but also to nonmotor symptoms, including gastrointestinal dysfunction. OBJECTIVE: The purpose of this pilot study was to evaluate the efficacy and safety profile of a traditional Japanese medicine, rikkunshito (RKT), used for the treatment of gastrointestinal symptoms, associated with anorexia and dyspepsia, in patients with PD. METHODS: Patients were randomly assigned to either Group A (4-week treatment period with 7...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28899670/definition-pathogenesis-and-management-of-that-cursed-dyspepsia
#5
REVIEW
Pramoda Koduru, Malcolm Irani, Eamonn M M Quigley
Dyspepsia is an umbrella term used to encompass a number of symptoms thought to originate from the upper gastrointestinal tract. These symptoms are relatively non-specific; not surprisingly, therefore, a myriad of conditions may present with any one or a combination of these symptoms. Therein lies the clinician's first challenge: detecting the minority who may have a potentially life-threatening disorder, such as gastric cancer, from a population whose symptoms are, for the most part, considered functional in origin...
September 9, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28894515/association-of-gastrointestinal-functional-disorders-and-migraine-headache-a-population-base-study
#6
Kamran B Lankarani, Maryam Akbari, Reza Tabrizi
BACKGROUND Migraine is one of the prevalent headaches. Many of patients with migraine, complain of gastrointestinal symptoms. There is limited studies on relation of gastrointestinal symptoms and migraine headache at population level. METHODS In this population-based study, 1038 subjects older than 15 year from a rural area in Fars province, south of Iran. were investigated for functional gastrointestinal disorders. By cluster random sampling, 160 of these persons invited to receive endoscopy along with histopathology samples of upper gastrointestinal tract...
July 2017: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28892908/cytological-diagnosis-of-an-uncommon-high-grade-malignant-thyroid-tumour-a-case-report
#7
Ruchi Nagpal, Manju Kaushal, Sawan Kumar
Anaplastic Thyroid Carcinoma (ATC) is a relatively uncommon highly malignant tumour originating from the follicular cells of thyroid gland having poor prognosis. It accounts for 2% to 5% of all thyroid carcinomas and patients typically present with a rapidly growing anterior neck mass with aggressive symptoms. A 53-year-old male presented with diffuse neck swelling measuring 8x6 cm and right cervical lymph node measuring 2x2 cm since one month which was associated with dyspepsia and dyspnoea. Ultrasound and Contrast Enhanced Computed Tomography (CECT) neck revealed enlarged right lobe of thyroid and multiple enlarged cervical lymph nodes with soft tissue density nodules in bilateral lungs...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28891136/helicobacter-pylori-infection-and-nonmalignant-diseases
#8
REVIEW
Olga Sjomina, Frederic Heluwaert, Driffa Moussata, Marcis Leja
A substantial decrease in Helicobacter pylori-associated peptic ulcer disease has been observed during the last decades. Drug-related ulcers as well as idiopathic ulcers are becoming predominant and are more refractory to treatment; however, H. pylori infection still plays an important role in ulcer bleeding and recurrence after therapy. The effect of H. pylori eradication upon functional dyspepsia symptoms has been reviewed in this article and generally confirms the results of previous meta-analyses. Additional evidence suggests a lack of impact upon the quality of life, in spite of improvement in symptoms...
September 2017: Helicobacter
https://www.readbyqxmd.com/read/28887755/prokinetics-in-the-management-of-functional-gastrointestinal-disorders
#9
REVIEW
Eamonn M M Quigley
PURPOSE OF REVIEW: The goal of this review is to review the current status of prokinetics and to place it in historical context. Impaired motility and thus propulsion have long been thought to play important roles in the pathogenesis of a number of gastrointestinal disorders including gastroesophageal reflux disease (GERD), gastroparesis, chronic idiopathic pseudo-obstruction, and constipation. Historically, disordered motility was also thought to contribute to a number of functional gastrointestinal disorders such as functional dyspepsia (FD) and irritable bowel syndrome (IBS)...
September 8, 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28884565/how-should-we-manage-patients-with-functional-dyspepsia-in-clinical-practice
#10
Edda Battaglia, Mario Grassini
No abstract text is available yet for this article.
September 7, 2017: Minerva Medica
https://www.readbyqxmd.com/read/28883239/superior-mesenteric-artery-syndrome-may-be-overlooked-in-women-with-functional-dyspepsia
#11
Koki Kawanishi, Kensaku Shojima, Masayuki Nishimoto, Hiroko Abe, Tetsuhiro Kakimoto, Yuko Yasuda, Takeshi Hara, Jun Kato
Objective Superior mesenteric artery (SMA) syndrome is characterized by the compression of the third segment of the duodenum between the SMA and aorta, resulting in duodenal obstruction. Because the symptoms of the syndrome are similar to those of functional dyspepsia (FD), this study aimed to examine whether or not patients with SMA syndrome were present among those diagnosed with FD. Methods Patients with an FD diagnosis underwent measurement of the angle and distance between the SMA and aorta by ultrasonography or computed tomography...
September 6, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28877088/efficacy-and-tolerability-of-culture-guided-treatment-for-helicobacter-pylori-infection
#12
Samuel Costa, João-Bruno Soares, Raquel Gonçalves
OBJECTIVE: The aim of this study was to evaluate the efficacy/tolerability of a culture-guided approach in the eradication of Helicobacter pylori and identify factors associated with antibiotic resistance/treatment failure. PATIENTS AND METHODS: This retrospective single-center study included patients who underwent culture-guided treatment for H. pylori infection, after two ineffective eradication attempts, between October 2012 and December 2016. We assessed the following demographic and clinical data of the patients: sex, age, BMI, alcohol and tobacco consumption, history of dyspepsia, peptic ulceration and first-degree relatives with gastric cancer, antibiotic susceptibility results, treatment composition, tolerability, and success...
September 4, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28875974/-functional-gastrointestinal-disorders-in-children-and-adolescents-the-rome-iv-criteria
#13
REVIEW
Barbara Iwańczak, Franciszek Iwańczak
In the work diagnostic criteria of functional disorders of the gastrointestinal tract in children and adolescents aged 4 to 18 years are presented. The criteria were elaborated by experienced experts in pediatrics and gastroenterology and were presented on Digestive Disease Week in San Diego in 2016 as modified IV Rome Criteria. In the work the following functional disorders are discussed: cyclic vomiting syndrome, functional nausea and vomiting, rumination syndrome, aerophagia, functional dyspepsia, irritable bowel syndrome, abdominal migraine, functional abdominal pain - not otherwise specified, functional constipation, nonretentive fecal incontinence...
August 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28874084/impaired-vagal-activity-to-meal-in-patients-with-functional-dyspepsia-and-delayed-gastric-emptying
#14
W-J Guo, S-K Yao, Y-L Zhang, S-Y Du, H-F Wang, L-J Yin, H-L Li
Objective This study was performed to investigate impaired vagal activity to meal in patients with functional dyspepsia (FD) with delayed gastric emptying (GE). Methods Eighty-five patients were studied. GE parameters, including those in the overall and proximal stomach, were measured by GE functional tests at the Department of Nuclear Medicine. Autonomic nervous function was tested by spectral analysis of heart rate variability (HRV). The vagal activity and sympathetic activity were analyzed by recording the power in the high-frequency component (HF), low-frequency component (LF), and LF/HF ratio...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28871092/acupuncture-and-related-therapies-used-as-add-on-or-alternative-to-prokinetics-for-functional-dyspepsia-overview-of-systematic-reviews-and-network-meta-analysis
#15
Robin S T Ho, Vincent C H Chung, Charlene H L Wong, Justin C Y Wu, Samuel Y S Wong, Irene X Y Wu
Prokinetics for functional dyspepsia (FD) have relatively higher number needed to treat values. Acupuncture and related therapies could be used as add-on or alternative. An overview of systematic reviews (SRs) and network meta-analyses (NMA) were performed to evaluate the comparative effectiveness of different acupuncture and related therapies. We conducted a comprehensive literature search for SRs of randomized controlled trials (RCTs) in eight international and Chinese databases. Data from eligible RCTs were extracted for random effect pairwise meta-analyses...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28866702/a-fatal-gastric-perforation-secondary-to-ulcerated-metastasis-in-undiagnosed-breast-cancer-pathological-aspects-and-review-of-literature
#16
R Barranco, G F Orcioni, F Ventura
The authors describe a fatal case of gastric perforation secondary to an ulcerated metastasis in a woman with undiagnosed breast cancer. The 48-year-old woman, with no significant medical history, presented with weight loss, persistent dyspepsia and pain in the epigastric and mesogastric region. She was treated by her primary care physician with proton-pump inhibitors and antispasmodics. The following day she was found dead at her home. External examination showed a tumefaction in the lateral region of her left breast, near the axilla...
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28865098/therapy-of-gerd-and-fd-overlap-with-symptoms-after-usual-dose-ppi-acotiamide-plus-usual-dose-ppi-vs-double-dose-ppi
#17
Toshihisa Takeuchi, Yoshiaki Takahashi, Shinpei Kawaguchi, Kazuhiro Ota, Satoshi Harada, Yuichi Kojima, Hiroki Sakamoto, Takanori Kuramoto, Keishi Kojima, Makoto Sanomura, Masahiro Hoshimoto, Takeshi Higashino, Tsukasa Itabashi, Ko Takada, Masahiro Sakaguchi, Kazunari Tominaga, Motoyasu Kusano, Kazuhide Higuchi
BACKGROUND AND AIM: Gastroesophageal reflux disease (GERD) and functional dyspepsia (FD) often coexist or overlap. In this study, the efficacy of acotiamide in combination with a standard dose of rabeprazole for GERD and FD was compared with that of a double dose of rabeprazole. METHODS: Patients with overlap between GERD and FD experiencing heartburn and epigastric fullness symptoms after standard-dose proton pump inhibitor (PPI) for ≥8 weeks were randomized into two groups, and received either acotiamide 300 mg/day + rabeprazole 10 mg/day or rabeprazole 20 mg/day for 4 weeks...
September 1, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28862247/ectopic-adrenocorticotropic-hormone-syndrome-in-a-case-of-duodenal-neuroendocrine-tumor-presenting-with-liver-metastasis
#18
J Khare, S Daga, S Nalla, P Deb
Ectopic adrenocorticotropic hormone (ACTH) syndrome is an uncommon disorder and comprises about 15% of all patients with Cushing's syndrome (CS). Duodenal carcinoids are rare, indolent tumors usually associated with a benign progression. We hereby report a rare case of CS resulting from ectopic ACTH secretion from a duodenal neuroendocrine tumor (NET) presenting with liver metastasis. A 37-year-old female presented with abdominal discomfort and dyspepsia of 1-month duration. Ultrasound abdomen suggested a well-defined hypoechoic lesion in the left lobe of the liver, suggestive of neoplasia...
August 31, 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/28859216/evaluating-the-multitarget-effects-of-combinations-through-multistep-clustering-of-pharmacological-data-the-example-of-the-commercial-preparation-iberogast
#19
Heba Abdel-Aziz, Olaf Kelber, Gerhard Lorkowski, Martin Storr
Herbal combination preparations are widely used in traditional herbal medicine and are even established as modern evidence-based herbal medicinal products. The rationale behind such combinations is often questioned and assessing the contribution of each of the combination partners to overall activity is challenging. STW 5 (Iberogast) is such a combination with confirmed clinical efficacy in functional gastrointestinal disorders. It consists of nine plant extracts responsible for its multitarget function in these multifactorial diseases with their heterogeneous and overlapping pathomechanisms...
August 31, 2017: Planta Medica
https://www.readbyqxmd.com/read/28854971/sini-san-improves-duodenal-tight-junction-integrity-in-a-rat-model-of-functional-dyspepsia
#20
Xiongfei Chang, Luqing Zhao, Jiajia Wang, Xiaofang Lu, Shengsheng Zhang
BACKGROUND: Recent reports have demonstrated that impaired barrier function and local microinflammation in the duodenal mucosa contribute to the pathogeneses of functional dyspepsia (FD). Thus, restoring normal barrier integrity becomes a potential therapeutic strategy in the treatment of FD. Sini-San (SNS) is a traditional Chinese prescription that exhibits therapeutic effects in FD, but the underlying mechanisms remain not well understood. METHODS: FD rats were established by tail clamping method and the therapeutic effect of SNS was evaluated by measuring the visceral sensitivity and gastric compliance...
August 30, 2017: BMC Complementary and Alternative Medicine
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