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Dyspepsia

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https://www.readbyqxmd.com/read/29348380/effect-of-nigella-sativa-seed-extract-for-hypertension-in-elderly-a-double-blind-randomized-controlled-trial
#1
Aulia Rizka, Siti Setiati, Aida Lydia, Esthika Dewiasty
BACKGROUND: Nigella sativa (NS) seed extract shows diuretic activity, inhibits sympathetic nervous system overactivity and increases the production of Nitric Oxide in in vivo studies, thus it has a potential use as an adjuvant antihypertensive for elderly population. This study aimed to determine the effect of Nigella sativa seed extract to systolic blood pressure (SBP) and diastolic blood pressure (DBP) of elderly patients with hypertension. METHODS: a double-blind, randomized controlled trial was conducted on elderly subjects with hypertension in three outpatient clinics in Cipto Mangunkusumo National Hospital Jakarta Indonesia from June to September 2011...
October 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29348090/pharmacological-validation-of-the-folkloric-uses-of-cyperus-rotundus-l-in-different-ailments-an-in-vivo-and-in-vitro-research
#2
Musaddique Hussain, Hafiz Muhammad Waqas, Ikhlaq Hussain, Abdul Majeed, Shahid Masood Raza, Khalid Hussain Janbaz
In vivo and in vitro research study was conducted on Cyperus rotundus to evaluate the sound mechanistic background in the treatment of gastrointestinal, bronchial and vascular disorders as well as in pain, emesis, pyrexia and bacterial infections. Results showed that crude extract of Cyperus rotundus (Cr.Cr) exhibited the dose-dependent spasmolytic effect in rabbit jejunum by inhibiting the spontaneous and K+ (80 mM)-induced contractions. Pretreatment of tissue with Cr. Cr caused the rightward shift of calcium concentration response curves, similar to verapamil...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29347978/uninvestigated-dyspepsia-and-associated-factors-of-patients-with-gastrointestinal-disorders-in-dessie-referral-hospital-northeast-ethiopia
#3
Abdurahaman Seid, Zemenu Tamir, Wondmagegn Demsiss
BACKGROUND: Dyspepsia is a common problem in the community and clinical practice with symptom(s) considered arising from the gastroduodenal region. Dyspepsia burden and associated factors vary from country to country. The aim of this study was to determine the prevalence of uninvestigated dyspepsia (UD) using Rome III criteria, associated risk factors and self-reported dyspepsia symptoms' correlation with H. pylori infection. METHODS: A cross-sectional study was conducted among randomly selected 318 out patients with gastrointestinal complaints during the period from September 1 to December 30, 2015...
January 18, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29344328/management-of-functional-dyspepsia-state-of-the-art-and-emerging-therapies
#4
REVIEW
Hiroshi Yamawaki, Seiji Futagami, Mako Wakabayashi, Noriko Sakasegawa, Shuhei Agawa, Kazutoshi Higuchi, Yasuhiro Kodaka, Katsuhiko Iwakiri
Patients with functional dyspepsia, defined in the 2016 Rome IV criteria as bothersome clinical dyspepsia symptoms, experience markedly reduced quality of life. Several etiologies have been associated with the disorder. In the Rome IV criteria, the brain-gut axis was acknowledged as an important factor in the etiology of functional gastrointestinal (GI) disorders. The distinct subgroups of functional dyspepsia, epigastric pain syndrome (EPS) and postprandial distress syndrome (PDS), are treated differently: acid secretion inhibitors are recommended with patients with EPS, whereas prokinetic drugs as mosapride and acotiamide are recommended for patients with PDS...
January 2018: Therapeutic Advances in Chronic Disease
https://www.readbyqxmd.com/read/29340256/clinical-cholecystitis-in-the-absence-of-the-gallbladder
#5
Huda Naim, Syed Askari Hasan, Sameen Khalid, Aamer Abbass, Jason DSouza
The congenital absence of the gallbladder (CAG) is a rare condition with an incidence of 13-65 cases/ 100,000 in the general population. This occurs when the gallbladder and the cystic duct fail to bud from the common bile duct during the fifth week of gestation. Most commonly, the patients with congenital absence of the gallbladder are asymptomatic. When symptomatic, they present as biliary colic, dyspepsia, jaundice or very rarely as acute cholecystitis. We present a case of a 27-year-old female who presented with acute right upper quadrant abdominal pain...
November 10, 2017: Curēus
https://www.readbyqxmd.com/read/29339955/highlights-in-functional-dyspepsia-treatment-from-digestive-disease-week-2017-may-6-9-2017-%C3%A2-chicago-illinois
#6
(no author information available yet)
No abstract text is available yet for this article.
December 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29330654/risk-prediction-model-for-severe-postoperative-complication-in-bariatric-surgery
#7
Erik Stenberg, Yang Cao, Eva Szabo, Erik Näslund, Ingmar Näslund, Johan Ottosson
BACKGROUND: Factors associated with risk for adverse outcome are important considerations in the preoperative assessment of patients for bariatric surgery. As yet, prediction models based on preoperative risk factors have not been able to predict adverse outcome sufficiently. OBJECTIVE: This study aimed to identify preoperative risk factors and to construct a risk prediction model based on these. METHODS: Patients who underwent a bariatric surgical procedure in Sweden between 2010 and 2014 were identified from the Scandinavian Obesity Surgery Registry (SOReg)...
January 12, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29319752/effectiveness-of-aqueous-and-hydroalcoholic-extracts-of-acanthospermum-australe-loefl-kuntze-against-diarrhea-inducing-bacteria
#8
R Mallmann, E M Ethur, P Bianchetti, D Faleiro, L Hoehne, M I Goettert
Leaves and roots of Acanthospermum australe (Asteraceae) have been used in Brazilian folk medicine for the treatment of various ailments including diarrhea, skin diseases, blennorrhagia, dyspepsia, parasitic worms and malaria. The aim of study was to characterize the chemical profiles of the aqueous and hydroalcoholic extracts of leaves and roots of A. australe, and to evaluate their antimicrobial activities against diarrhea-inducing bacteria (Enterococcus faecalis, Shigella dysenteriae and Yersinia enterocolitica), as well as their cytotoxic properties...
January 8, 2018: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/29315999/long-term-safety-and-efficacy-of-acotiamide-in-functional-dyspepsia-postprandial-distress-syndrome-results-from-the-european-phase-3-open-label-safety-trial
#9
J Tack, J Pokrotnieks, G Urbonas, C Banciu, V Yakusevich, I Bunganic, H Törnblom, Y Kleban, P Eavis, M Tsuchikawa, T Miyagawa
BACKGROUNDS: Acotiamide is a novel acetylcholinesterase inhibitor for treatment of postprandial distress syndrome (PDS) symptoms of functional dyspepsia (FD). This European phase 3 open-label safety trial has been conducted to evaluate the long-term safety of acotiamide and explore the efficacy of acotiamide on PDS symptoms using the validated LPDS, quality of life using SF-36 and SF-NDI, and work productivity using WPAI. METHODS: FD-PDS patients (defined by ROME III criteria) aged ≥18 years with active PDS symptoms and without predominant overlapping symptoms of epigastric pain syndrome and related disorders were enrolled to receive 100 mg acotiamide three times daily for 1 year...
January 8, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29314744/clinical-and-economic-implications-of-upper-gastrointestinal-adverse-events-in-asian-rheumatological-patients-on-long-term-non-steroidal-anti-inflammatory-drugs
#10
Lydia Say Lee Pok, Fatiha Hana Shabaruddin, Maznah Dahlui, Sargunan Sockalingam, Mohd Shahrir Mohamed Said, Azmillah Rosman, Ing Soo Lau, Liza Mohd Isa, Heselynn Hussein, Chin Teck Ng, Sanjiv Mahadeva
AIM: To determine the incidence and direct costs of NSAID-induced upper GI adverse events in Malaysian rheumatology patients. METHODS: A retrospective, multi-centre, cohort study of rheumatology patients on long-term NSAIDs was conducted. Clinical data of patients treated between 2010 and 2013 were collected for a 24-month follow-up period. The costs of managing upper GI adverse events were based on patient level resource use data. RESULTS: Six hundred and thirty-four patients met the inclusion criteria: mean age 53...
January 5, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29313700/a-question-about-dyspeptic-patients-analyzed-using-psychometric-scores
#11
Rinaldo Pellicano, Marilena Durazzo
Orive et al. reported the results of a randomized study that included patients with functional dyspepsia (FD) treated with standard versus standard plus a psychological approach. Reliability (Cronbach's alpha), validity (confirmatory factor analysis [FA]) and responsiveness were analyzed using specific questionnaires.
January 9, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29313514/upper-gastrointestinal-tract-endoscopic-lesions-in-a-rural-african-hospitalo-252%C3%A2-endoscopies-at-the-kara-university-hospital-togo
#12
O Bouglouga, A Bagny, L M Lawson-Ananissoh, K Amanga, R El-Hadj Yakoubou, L Kaaga, M Djibril, D Redah
To analyze the indications for upper gastrointestinal endoscopy (UGIE) and determine the frequency of the pathological findings observed in rural areas of Africa. This retrospective study includes 9 series of 5-day visits to perform these examinations. Patients were informed of the presence of the endoscopy team by a bulletin on a rural radio station and by general practitioners at the Kara University Hospital. Patients were recruited from the hospital clinics and from the general population of the Kara region...
November 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29311735/test-and-treat-h-pylori-eradication-in-dyspepsia-a-bridge-too-far-in-the-concensus
#13
Wojciech Marlicz, Karolina Skonieczna-Zydecka, Igor Łoniewski
No abstract text is available yet for this article.
January 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29306868/gastritis-staging-in-the-endoscopic-follow-up-for-the-secondary-prevention-of-gastric-cancer-a-5-year-prospective-study-of-1755-patients
#14
Massimo Rugge, Alberto Meggio, Cecilia Pravadelli, Mattia Barbareschi, Matteo Fassan, Maria Gentilini, Manuel Zorzi, Giovanni De Pretis, David Y Graham, Robert M Genta
OBJECTIVE: Operative link on gastritis assessment (OLGA) staging for gastritis ranks the risk for gastric cancer (GC) in progressive stages (0-IV). This prospective study aimed at quantifying the cancer risk associated with each gastritis stage. DESIGN: A cohort of 1755 consecutive patients with dyspepsia underwent initial (T-0) oesophagogastroduodenoscopy with mapped gastric biopsies, OLGA staging and assessment of Helicobacter pylori infection. Patients were followed for 55 months (median); patients with stages II III and IV underwent a second endoscopy/restaging (T-1), and those with stages 0 and I were followed clinically and through in-depth clinical and record checking...
January 6, 2018: Gut
https://www.readbyqxmd.com/read/29303047/eltrombopag-in-the-management-of-aplastic-anaemia-real-world-experience-in-a-non-trial-setting
#15
Yu-Yan Hwang, Harinder Gill, Thomas S Y Chan, Garret M K Leung, Carol Y M Cheung, Yok-Lam Kwong
OBJECTIVE: The thrombopoietin mimetic eltrombopag has been used in clinical trials for the frontline and salvage treatment of aplastic anaemia (AA). Eltrombopag was investigated in AA patients on a non-trial all-comer basis. METHODS: Consecutive newly diagnosed and relapsed/refractory AA patients were treated with eltrombopag. RESULTS: In a 4.5-year period, 20 consecutive AA patients (newly diagnosed, N = 10; relapsed/refractory, N = 10) at a median age of 47 (22-84) years were treated with eltrombopag...
January 5, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29302146/helicobacter-pylori-in-dyspepsia-phenotypic-and-genotypic-methods-of-diagnosis
#16
Vignesh Shetty, Mamatha Ballal, Girisha Balaraju, Shiran Shetty, Ganesh C Pai, Ramachandra Lingadakai
Background: Helicobacter pylori affects almost half of the world's population and therefore is one of the most frequent and persistent bacterial infections worldwide. H. pylori is associated with chronic gastritis, ulcer disease (gastric and duodenal), mucosa-associated lymphoid tissue lymphoma, and gastric cancer. Several diagnostic methods exist to detect infection and the option of one method or another depends on various genes, such as availability, advantages and disadvantages of each method, monetary value, and the age of patients...
October 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29299438/effect-of-apium-graveolens-and-trachyspermum-copticom-on-clinical-symptoms-of-patients-with-functional-dyspepsia
#17
Maryam Azimi, Mohammad Javad Zahedi, Mitra Mehrabani, Haleh Tajadini, Farzaneh Zolala, Mohammad Reza Baneshi, Rasool Choopani, Fariba Sharififar, Ali Asadipour, Mohammad Mahdi Hayatbakhsh, Bijan Ahmadi
Objectives: This study aimed at investigating the effect of Iranian traditional remedy prepared from Apium graveolens and Trachyspermum copticom (AT) on the severity and frequency of symptoms in patients with functional dyspepsia (FD). Material and Methods: In total, 150 FD patients were included in this randomized double-blind trial, based on the ROME III diagnostic criteria, and they were divided into three intervention groups namely, AT, Placebo and omeprazole...
November 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/29296572/feasibility-study-of-structured-diagnosis-methods-for-functional-dyspepsia-in-korean-medicine-clinics
#18
Jeong Hwan Park, Soyoung Kim, Jae-Woo Park, Seok-Jae Ko, Sanghun Lee
Background: Functional dyspepsia (FD) is the seventh most common disease encountered in Korean medicine (KM) clinics. Despite the large number of FD patients visiting KM clinics, the accumulated medical records have no utility in evidence development, due to being unstructured. This study aimed to construct a standard operating procedure (SOP) with appropriate structured diagnostic methods for FD, and assess the feasibility for use in KM clinics. Methods: Two rounds of professional surveys were conducted by 10 Korean internal medicine professors to select the representative diagnostic methods...
December 2017: Integrative medicine research
https://www.readbyqxmd.com/read/29284270/measuring-health-related-quality-of-life-hrqol-in-functional-dyspepsia-is-it-really-important
#19
Belén Herreros Martínez, Pedro Almela Notari, Cirilo Amorós García
Concern for measuring health outcomes in real life and from the patient's perspective has been for years included in the management o many and various diseases, regardless of the presence or absence of a known organic basis and/or objective markers associated with their course or response to treatments. This approach partly results from patient inclusion in decisions involving their health, and also from the health definition put forward by the World Health Organization (WHO) as a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity...
December 28, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29282046/evaluation-of-pharmacodynamic-properties-and-safety-of-cinnamomum-zeylanicum-ceylon-cinnamon-in-healthy-adults-a-phase-i-clinical-trial
#20
Priyanga Ranasinghe, Ranil Jayawardena, Shehani Pigera, Wasundara Sevwandi Wathurapatha, Hasitha Dhananjaya Weeratunga, G A Sirimal Premakumara, Prasad Katulanda, Godwin Roger Constantine, Priyadarshani Galappaththy
BACKGROUND: Cinnamon is considered as a treatment for many ailments in native medicine. Evidence suggests that Cinnamomum zeylanicum (CZ) has anti-microbial, anti-parasitic, anti-oxidant, blood glucose lowering properties and beneficial cardiovascular effects. The present study aims to evaluate Pharmacodynamic properties and safety of CZ in healthy adults using a Phase I Clinical Trial. METHODS: This phase I clinical trial was conducted at the Department of Pharmacology, Faculty of Medicine, University of Colombo, Sri Lanka...
December 28, 2017: BMC Complementary and Alternative Medicine
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