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Dyspepsia

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https://www.readbyqxmd.com/read/28441784/tim-3-up-regulation-in-patients-with-gastric-cancer-and-peptic-ulcer-disease
#1
Mahdieh aghavi-Alhosseini, Mohsen Tehrani, Abolghasem Ajami, Alireza Rafiei, Tarang Taghvaei, Laleh Vahedi-Larijani, Hadi Hossein-Nataj, Hossein Asgarian-Omran
Background: T-cell immunoglobulin and mucin domain protein-3 (Tim-3), an inhibitory immunoregulatory receptor, has been recently implicated in tumor biology and tumor-associated immune suppression. In the present study, expression of Tim-3 was evaluated in gastric cancer (GC) and peptic ulcer disease (PUD) at both mRNA and protein levels. Methods: A total of 133 gastric tissue biopsies, comprising 43 from GC cases, 48 from PUD and 42 from non-ulcer dyspepsia (NUD) serving as controls were collected. Additionally, non-neoplastic adjacent tissue biopsies were also obtained from 6 patients with GC...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28431454/da-9701-improves-colonic-transit-time-and-symptoms-in-patients-with-functional-constipation-a-prospective-study
#2
Su Young Kim, Hyun Sun Woo, Sung Han Choi, Dong Kyun Park, Kwang An Kwon, Jun-Won Chung, Yoon Jae Kim, Jung Ho Kim, Su Ji Kim, Kyoung Oh Kim
BACKGROUND AND AIM: DA-9701, a newly developed prokinetic agent formulated with Pharbitis Semen and Corydalis Tuber, has been shown to effectively treat functional dyspepsia. Recently, it has also been suspected to improve gastrointestinal motor function. The aims of this study were to assess the effect of DA-9701 on colonic transit time (CTT) and symptoms of functional constipation. METHODS: We prospectively enrolled 33 patients with functional constipation based on the Rome III criteria...
April 21, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28424994/modulation-of-gastrointestinal-motility-beyond-metoclopramide-and-domperidone-pharmacological-and-clinical-evidence-for-phytotherapy-in-functional-gastrointestinal-disorders
#3
Ahmed Madisch, Bettina R Vinson, Heba Abdel-Aziz, Olaf Kelber, Karen Nieber, Karin Kraft, Martin Storr
The prokinetic cisapride, an important therapeutic option in functional gastrointestinal (GI) disorders, was withdrawn from the market 15 years ago due to rare severe side effects. Likewise in 2014, the use of metoclopramide (MCP) and domperidone in functional GI disorders (FGID) was restricted, consequently leaving a therapeutic gap in clinical practice. A systematic review revealed that the herbal medicinal product (HMP) STW 5 presents a therapeutic option equivalent to MCP and cisapride. STW 5 is the only HMP for which efficacy has been shown in randomized controlled clinical trials (RCTs) in functional dyspepsia and irritable bowel syndrome, based on its multitarget effect on numerous etiological factors...
April 19, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28423481/prevalence-of-gastric-motility-disorders-in-patients-with-functional-dyspepsia
#4
Haruki Asano, Toshihiko Tomita, Kumiko Nakamura, Takahisa Yamasaki, Takuya Okugawa, Takashi Kondo, Tomoaki Kono, Katsuyuki Tozawa, Yoshio Ohda, Tadayuki Oshima, Hirokazu Fukui, Kazuhito Fukushima, Shozo Hirota, Jiro Watari, Hiroto Miwa
Background/Aims: Gastric motility abnormalities have been considered to be pathophysiological features of functional dyspepsia (FD) that are closely related to dyspepsia symptoms, especially postprandial distress syndrome (PDS). The aims of this study are to (1) investigate the prevalence of gastric motility disorders and (2) evaluate the association between gastric motility abnormalities and dyspeptic symptoms using gastric scintigraphy in the PDS type of FD. Methods: Forty healthy subjects and 94 PDS type FD patients were enrolled in the study...
April 19, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28422887/epigastric-symptoms-of-gallbladder-dyskinesia-mistaken-for-functional-dyspepsia-retrospective-observational-study
#5
Sung Won Jung, Min Sun Joo, Hyun Chang Choi, Sung Ill Jang, Young Sik Woo, Jin Bae Kim, Sang Hoon Park, Myung Seok Lee
Functional dyspepsia (FD) is a constellation of epigastric symptoms originating in the gastroduodenal region without organic and metabolic cause. However, similar confounding symptoms can also appear in patients with gallbladder (GB) dyskinesia. Therefore, symptoms of GB dyskinesia may be mistaken for FD. We aimed to identify GB dyskinesia as a cause of FD symptoms compatible with the Rome IV criteria and the need for an evaluation of GB function in patients with FD symptoms.We investigated information of patients with FD symptoms who underwent a quantitative Tc-diisoproyl iminodiacetic acid cholescintigraphy (DISIDA scan) through electronic medical records, and GB dyskinesia was judged to be the cause of the FD symptoms if the symptoms disappeared as GB function normalized on the follow-up DISIA scan in patient with decreased GB function on the initial DISIDA scan...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28419119/plasma-ghrelin-level-and-plasma-ghrelin-obestatin-ratio-are-related-to-intestinal-metaplasia-in-elderly-patients-with-functional-dyspepsia
#6
Su Hwan Kim, Ji Won Kim, Junsu Byun, Ji Bong Jeong, Byeong Gwan Kim, Kook Lae Lee
BACKGROUND: Whether plasma ghrelin/obestatin levels are associated with Helicobacter pylori (H. pylori) infection, subtypes of functional dyspepsia (FD), and gastric mucosal histology has not yet been established in elderly patients. OBJECTIVE: The aim of this study was to determine whether plasma ghrelin and obestatin levels are related to gastric mucosal histology, H. pylori infection, and FD subtypes in elderly patients with FD. METHODS: Ninety-two patients diagnosed with FD and older than 60 years (median age 69...
2017: PloS One
https://www.readbyqxmd.com/read/28417420/-current-treatment-of-dyspepsia-in-primary-care
#7
Constanze H Waggershauser, Hans-Dieter Allescher, Martin Storr
No abstract text is available yet for this article.
April 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/28413454/helicobacter-pylori-vaca-s1m1-genotype-but-not-caga-or-baba2-increase-the-risk-of-ulcer-and-gastric-cancer-in-patients-from-southern-mexico
#8
Adolfo Román-Román, Dinorah Nashely Martínez-Carrillo, Josefina Atrisco-Morales, Julio César Azúcar-Heziquio, Abner Saúl Cuevas-Caballero, Carlos Alberto Castañón-Sánchez, Roxana Reyes-Ríos, Reyes Betancourt-Linares, Salomón Reyes-Navarrete, Iván Cruz-Del Carmen, Margarita Camorlinga-Ponce, Enoc Mariano Cortés-Malagón, Gloria Fernández-Tilapa
BACKGROUND: The vacA, cagA and babA2 genotypes of Helicobacter pylori are associated with gastric pathology. The objectives were to determine the frequency of infection and distribution of the vacA, cagA and babA2 genotypes of H. pylori in patients with gastric ulcer, chronic gastritis and gastric cancer, and to evaluate the association of virulent genotypes with diagnosis. METHODS: We studied 921 patients with symptoms of dyspepsia or with presumptive diagnosis of gastric cancer...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28413079/mexican-consensus-on-dyspepsia
#9
R Carmona-Sánchez, O Gómez-Escudero, M Zavala-Solares, M V Bielsa-Fernández, E Coss-Adame, A I Hernández-Guerrero, F Huerta-Iga, M E Icaza-Chávez, M A Lira-Pedrín, J A Lizárraga-López, A López-Colombo, A Noble-Lugo, J Pérez-Manauta, R H Raña-Garibay, J M Remes-Troche, J L Tamayo, L F Uscanga, F Zamarripa-Dorsey, M A Valdovinos Díaz, J A Velarde-Ruiz Velasco
Since the publication of the 2007 dyspepsia guidelines of the Asociación Mexicana de Gastroenterología, there have been significant advances in the knowledge of this disease. A systematic search of the literature in PubMed (01/2007 to 06/2016) was carried out to review and update the 2007 guidelines and to provide new evidence-based recommendations. All high-quality articles in Spanish and English were included. Statements were formulated and voted upon using the Delphi method. The level of evidence and strength of recommendation of each statement were established according to the GRADE system...
April 13, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28412148/no-evidence-to-support-a-role-for-helicobacter-pylori-infection-and-plasminogen-binding-protein-in-autoimmune-pancreatitis-and-igg4-related-disease-in-a-uk-cohort
#10
Emma L Culver, Wouter L Smit, Caroline Evans, Ross Sadler, Tamsin Cargill, Mateusz Makuch, Lai-Mun Wang, Berne Ferry, Paul Klenerman, Eleanor Barnes
BACKGROUND AND OBJECTIVES: Helicobacter pylori (H.pylori) plasminogen binding protein (PBP) has been proposed as an antigen triggering autoimmune pancreatitis (AIP), the pancreatic manifestation of IgG4-related disease (IgG4-RD). We investigated exposure to H. pylori infection, cytokine response and immunological memory to H. pylori PBP in a prospective IgG4-RD cohort in the UK. METHODS: Clinical and endoscopic evidence of peptic ulceration, serological H. pylori exposure and serum IgG4 levels were obtained in 55 IgG4-RD patients and 52 disease controls (DC) with autoimmune or inflammatory conditions with an elevated serum IgG4...
April 5, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28405322/specific-dyspeptic-symptoms-are-associated-with-poor-response-to-therapy-in-patients-with-gastroesophageal-reflux-disease
#11
A D'Alessandro, F P Zito, M Pesce, P Andreozzi, E Efficie, M Cargiolli, F Maione, G D De Palma, R Cuomo, G Sarnelli
INTRODUCTION: In patients with gastroesophageal reflux disease (GORD), co-existence of functional dyspepsia (FD) is known to be associated with poor response to proton pump inhibitors (PPIs), but the contribution of specific dyspepsia symptoms has not yet been systematically investigated. OBJECTIVE: We aimed to characterize the impact of dyspepsia symptoms on response to PPIs in patients with GORD. METHODS: The enrolled subjects were consecutive patients with a diagnosis of GORD...
February 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28405154/breast-cancer-metastasizing-to-the-stomach-mimicking-primary-gastric-cancer-a-case-report
#12
Kwangil Yim, Sang Mi Ro, Jieun Lee
Breast cancer with stomach metastasis rare with an incidence of 1% or less among metastatic breast cancer patients. We experienced a case of breast cancer metastasizing to the stomach in 65-year-old female patient. She experienced dyspepsia and poor oral intake before visiting the clinic. Diffuse infiltration with nodular mucosal thickening of the stomach wall was observed, suggesting advanced gastric cancer based on gross endoscopic finding. Spread of poorly cohesive tumor cells in the gastric mucosa observed upon hematoxylin and eosin stain resembled signet ring cell carcinoma, but diffuse positive staining for GATA3 in immunohistochemical stain allowed for a conclusive diagnosis of breast cancer metastasizing to the stomach...
March 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28404068/association-between-functional-gastrointestinal-disorders-and-migraine-in-children-and-adolescents-a-case-control-study
#13
Julie Le Gal, Jean-Francois Michel, Victoria Elisa Rinaldi, Daniele Spiri, Raffaella Moretti, Donatella Bettati, Silvia Romanello, Paola Berlese, Rosa Lualdi, Priscilla Boizeau, Jerome Viala, Marc Bellaiche, Gian Vincenzo Zuccotti, Giovanni Crichiutti, Corinne Alberti, Luigi Titomanlio
BACKGROUND: Functional gastrointestinal disorders and migraine are both common causes of medical attention. We have previously shown an association between migraine and infant colic. In this case-control study, we aimed to establish whether there is an association between migraine and other functional gastrointestinal disorders in children and adolescents. METHODS: We included children and adolescents aged 6-17 years presenting to the emergency department of four tertiary hospitals in France and Italy...
October 2016: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28400841/effects-of-a-herbal-medicine-yukgunja-tang-on-functional-dyspepsia-patients-classified-by-3-dimensional-facial-measurement-a-study-protocol-for-placebo-controlled-double-blind-randomized-trial
#14
Juyeon Kim, Jae-Woo Park, Seok-Jae Ko, Soo-Hyung Jeon, Jong-Won Kim, Inkwon Yeo, Jinsung Kim
Introduction. Functional dyspepsia (FD), a common upper gastrointestinal disease, is difficult to manage because of the limitations of current conventional treatments. Yukgunja-tang (YGJT) is widely used to treat FD in clinical practice in Korea, Japan, and China. However, YGJT significantly improves few symptoms of FD. In Korean medicine, FD is a well-known functional gastric disease that shows difference in the effect of herbal medicine depending on constitution or type of Korean medicine diagnosis. This study aims to investigate the efficacy of YGJT on FD patients classified by 3-dimensional facial measurement using a 3-dimensional facial shape diagnostic system (3-FSDS)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28395788/diagnosis-and-treatment-of-chronic-mesenteric-ischemia-an-update
#15
REVIEW
Jeroen J Kolkman, Robert H Geelkerken
Although the prevalence of mesenteric artery stenoses (MAS) is high, symptomatic chronic mesenteric ischemia (CMI) is rare. The collateral network in the mesenteric circulation, a remnant of the extensive embryonal vascular network, serves to prevent most cases of ischemia. This explains the high incidence of MAS and relative rarity of cases of CMI. The number of affected vessels is the major determinant in CMI development. Most subjects with single vessel mesenteric stenosis do not develop ischemic complaints...
February 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/28393479/inhibitory-effects-and-mechanisms-of-electroacupuncture-via-chronically-implanted-electrodes-on-stress-induced-gastric-hypersensitivity-in-rats-with-neonatal-treatment-of-iodoacetamide
#16
Jingzhu Zhou, Shiying Li, Yinping Wang, Robert D Foreman, Jieyun Yin, Shengsheng Zhang, Jiande D Z Chen
BACKGROUND: Stress is considered an independent factor causing and aggravating gastrointestinal symptoms, including visceral pain. The aim of this study was to investigate effects and mechanisms of electroacupuncture (EA) on stress-induced gastric hypersensitivity in rats treated with neonatal iodoacetamide mimicking human functional dyspepsia (FD). METHODS: Neonatal rats were treated with gavage of 0.2 mL of 0.1% iodoacetamide in 2% sucrose daily for six days starting on tenth day after birth...
April 10, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28392893/traditional-persian-topical-medications-for-gastrointestinal-diseases
#17
REVIEW
Laleh Dehghani Tafti, Seyyed Mahyar Shariatpanahi, Mahmoud Mahdavi Damghani, Behjat Javadi
Drug delivery across the skin is used for several millennia to ease gastrointestinal (GI) ailments in Traditional Persian Medicine (TPM). TPM topical remedies are generally being applied on the stomach, lower abdomen, lower back and liver to alleviate GI illnesses such as dyspepsia, gastritis, GI ulcers, inflammatory bowel disease, intestinal worms and infections. The aim of the present study is to survey the topical GI remedies and plant species used as ingredients for these remedies in TPM. In addition, pharmacological activities of the mentioned plants have been discussed...
March 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28387752/corrigendum-increased-duodenal-eosinophil-degranulation-in-patients-with-functional-dyspepsia-a-prospective-study
#18
Lijun Du, Jinhua Shen, John J Kim, Yunxian Yu, Liqin Ma, Ning Dai
No abstract text is available yet for this article.
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28385695/transient-receptor-potential-ion-channel-function-in-sensory-transduction-and-cellular-signaling-cascades-underlying-visceral-hypersensitivity
#19
Dafne Balemans, Guy E Boeckxstaens, Karel Talavera, Mira M Wouters
Visceral hypersensitivity is an important mechanism underlying increased abdominal pain perception in functional gastrointestinal disorders (FGID) including functional dyspepsia, irritable bowel syndrome (IBS) and inflammatory bowel disease in remission. Although the exact pathophysiological mechanisms are poorly understood, recent studies described upregulation and altered functions of nociceptors and their signaling pathways in aberrant visceral nociception, in particular the transient receptor potential (TRP) channel family...
April 6, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28385468/approach-attitudes-and-knowledge-of-general-practitioners-in-relation-to-helicobacter-pylori-is-inadequate-there-is-much-room-for-improvement
#20
A D Cano-Contreras, O Rascón, M Amieva-Balmori, S Ríos-Gálvez, Y J Maza, A Meixueiro-Daza, F Roesch-Dietlen, J M Remes-Troche
BACKGROUND: Helicobacter pylori (Hp) infection is one of the most common infections in humans. Due to its worldwide prevalence, a series of guidelines and recommendations has been developed for the appropriate screening, diagnosis, and management of patients with Hp infection. AIM: To evaluate the approach, attitudes, and knowledge of a group of Mexican general practitioners in relation to Hp. MATERIALS AND METHODS: A cross-sectional study was conducted that evaluated the knowledge of Hp diagnosis and treatment through the application of a questionnaire...
April 3, 2017: Revista de Gastroenterología de México
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