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Dyspepsia

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https://www.readbyqxmd.com/read/28087404/mood-and-anxiety-disorders-precede-development-of-functional-gastrointestinal-disorders-in-patients-but-not-in-the-population
#1
Michael P Jones, Jan Tack, Lukas Van Oudenhove, Marjorie M Walker, Gerald Holtmann, Natasha A Koloski, Nicholas J Talley
BACKGROUND & AIMS: Understanding the interactions between brain and gastrointestinal disorders requires analysis of the order of disease onset. We analyzed data from 2 independent studies to determine the proportion of individuals with diagnoses of functional gastrointestinal disorders (FGIDs) before diagnoses of mood or anxiety disorders (gut to brain), and vice versa (brain to gut). METHODS: We collected data from a retrospective study of 4966 patients diagnosed with a FGID (irritable bowel syndrome, dyspepsia, or constipation) and mood or anxiety disorder at general practices in the United Kingdom (health care seekers) over an average period of 13...
January 10, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28079239/prevalence-of-dyspeptic-symptoms-and-heartburn-of-adults-in-belo-horizonte-brazil
#2
Alessandra Maciel Almeida, Luísa Alvarenga Guerra Martins, Patrícia Liz Terenzi Cunha, Viviane Willig Brasil, Lucas Galuppo Fernandes Félix, Maria do Carmo Friche Passos
BACKGROUND: - Medical literature has shown dyspepsia and heartburn-related symptoms occur among 15% to 40% of the population. These symptoms can occur at any age and are more prevalent in women. OBJECTIVE: - Investigate the prevalence of dyspeptic symptoms and heartburn among individuals over 18. METHODS: - Individuals over 18 were randomly selected in public venues in Belo Horizonte/MG to participate. A standardized questionnaire that included questions related to social-demographic characteristics, eating habits, digestive symptoms, medical appointments, medications, exams, previous surgeries and comorbidities was applied...
January 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28079238/human-leukocyte-antigen-hladrb1-determinants-susceptibility-to-gastroesophageal-reflux-disease
#3
Batool Mutar Mahdi, Riyadh Mohamad Hasan, Wafaa Hazim Salih
BACKGROUND: - Gastroesophageal reflux disease (GERD) is characterized by diverse symptoms. There is an evidence for a genetic component to GERD as supported by familial aggregation of this disease. OBJECTIVE: - To investigate whether certain human leucocyte antigen genes HLA-DRB1 are associated with GERD. METHODS: - Patients and controls were prospectively recruited from GIT center at Al-Kindy Teaching Hospital (Baghdad-Iraq) between January 2014 and July 2016...
January 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28079237/celiac-disease-prevalence-is-not-increased-in-patients-with-functional-dyspepsia
#4
Juan Lasa, Liliana Spallone, Silvina Gandara, Elsa Chaar, Saul Berman, David Zagalsky
BACKGROUND: - Previous evidence trying to assess the risk of celiac disease among dyspeptic patients has been inconclusive, showing in some cases notorious discrepancies. OBJECTIVE: - To determine the prevalence of celiac disease in patients with dyspepsia compared to healthy controls without dyspepsia. METHODS: - Adult patients under evaluation for dyspepsia were invited to participate. These patients were offered an upper gastrointestinal endoscopy with duodenal biopsies...
January 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28072728/upper-gastrointestinal-symptoms-in-autoimmune-gastritis-a-cross-sectional-study
#5
Marilia Carabotti, Edith Lahner, Gianluca Esposito, Maria Carlotta Sacchi, Carola Severi, Bruno Annibale
Autoimmune gastritis is often suspected for its hematologic findings, and rarely the diagnosis is made for the presence of gastrointestinal symptoms. Aims of this cross-sectional study were to assess in a large cohort of patients affected by autoimmune gastritis the occurrence and the pattern of gastrointestinal symptoms and to evaluate whether symptomatic patients are characterized by specific clinical features.Gastrointestinal symptoms of 379 consecutive autoimmune gastritis patients were systematically assessed and classified following Rome III Criteria...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28071659/acg-clinical-guideline-treatment-of-helicobacter-pylori-infection
#6
William D Chey, Grigorios I Leontiadis, Colin W Howden, Steven F Moss
Helicobacter pylori (H. pylori) infection is a common worldwide infection that is an important cause of peptic ulcer disease and gastric cancer. H. pylori may also have a role in uninvestigated and functional dyspepsia, ulcer risk in patients taking low-dose aspirin or starting therapy with a non-steroidal anti-inflammatory medication, unexplained iron deficiency anemia, and idiopathic thrombocytopenic purpura. While choosing a treatment regimen for H. pylori, patients should be asked about previous antibiotic exposure and this information should be incorporated into the decision-making process...
January 10, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28054652/using-the-target-constituent-removal-combined-with-bioactivity-assay-strategy-to-investigate-the-optimum-arecoline-content-in-charred-areca-nut
#7
Wei Peng, Yu-Jie Liu, Mei-Bian Hu, Dan Yan, Yong-Xiang Gao, Chun-Jie Wu
Charred areca nut (CAN) is used to treat dyspepsia and abdominal distension in children. However, reports revealed that arecoline, the most important active constituent of CAN, possesses potential toxicities. This study was designed to investigate the optimum arecoline content in CAN, using the "target constituent removal combined with bioactivity assay" strategy. Based on PTLC method, we prepared CAN lacking all arecoline (WAC-100R) and a series of different ratios of arecoline-removed CAN samples (WAC-Rx)...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28053340/population-screening-and-treatment-of-helicobacter-pylori-infection
#8
REVIEW
Anthony O'Connor, Colm A O'Morain, Alexander C Ford
Helicobacter pylori is an important human pathogen, associated with a substantial burden from both malignant and non-malignant diseases. The bacterium is classed as a human carcinogen, being strongly linked with gastric cancer, the third most common cause of cancer death worldwide and is also associated with common conditions such as dyspepsia and peptic ulcer. Eradication of H. pylori reduces the incidence of gastric cancer and peptic ulcer, as well as the prevalence and costs of managing dyspepsia. Economic analyses suggest that eradication of H...
January 5, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28052285/gender-difference-of-gastric-emptying-in-healthy-volunteers-and-patients-with-functional-dyspepsia
#9
Hideki Mori, Hidekazu Suzuki, Juntaro Matsuzaki, Kanami Taniguchi, Toshiyuki Shimizu, Tsuyoshi Yamane, Tatsuhiro Masaoka, Takanori Kanai
BACKGROUND AND AIM: Delayed gastric emptying is one of the reasons why functional dyspepsia (FD) occurs. The 13C-acetate breath test is widely used to evaluate gastric emptying. Nevertheless, the standard value of 13C-acetate breath test has not taken into account the gender difference of gastric emptying among healthy individuals. The main aim of this study was to readjust the standard value of 13C-acetate breath test in the light of gender differences. In addition, we clarified the prevalence and clinical characteristics of delayed gastric emptying in patients with FD using the modified standard values of 13C-acetate breath test...
2017: Digestion
https://www.readbyqxmd.com/read/28050031/editorial-moving-away-from-focussing-on-gastric-pathophysiology-in-functional-dyspepsia-new-insights-and-therapeutic-implications
#10
Nicholas J Talley
Functional dyspepsia (FD) is a prevalent syndrome that affects up to one in six Americans, although misdiagnosis as gastroesophageal reflux disease may be common. Early satiety, postprandial fullness, and epigastric pain or burning are the cardinal symptoms. Traditionally, FD has been blamed on gastric dysfunction and much research effort has focussed on unlocking the gastric pathophysiology. New research suggests gastric dysfunction has only a minor role in the pathogenesis in many cases, and the focus has begun to shift to evaluation of duodenal feedback and subtle inflammation including duodenal eosinophilia...
January 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28041953/synthetic-approaches-towards-the-multi-target-drug-spironolactone-and-its-potent-analogues-derivatives
#11
REVIEW
Fayaz Ali Larik, Aamer Saeed, Danish Shahzad, Muhammad Faisal, Hesham El-Seedi, Haroon Mehfooz, Pervaiz Ali Channar
Spironolactone is a well-known multi-target drug and is specifically used for the treatment of high blood pressure and heart failure. It is also used for the treatment of edema, cirrhosis of the liver, malignant, pediatric, nephrosis and primary hyperaldosteronism. Spironolactone in association with thiazide diuretics treats hypertension and in association with furosemide treats bronchopulmonary dyspepsia. The therapeutic mechanism of action of spironolactone involves binding to intracellular mineralocorticoids receptors (MRs) in kidney epithelial cells, thereby inhibiting the binding of aldosterone...
December 29, 2016: Steroids
https://www.readbyqxmd.com/read/28033692/helicobacter-pylori-and-its-virulence-factors-effect-on-serum-oxidative-dna-damages-in-adults-with-dyspepsia
#12
Heshmat Shahi, Rasoul Bahreiny, Somayeh Reiisi
Helicobacter Pylori infection is a common gastrointestinal infection that can cause pathological effects, increase oxidative stress and induce an inflammatory response in gastric mucosa. Inflammatory aspects may prompt the production of radical oxygen substance (ROS) which may damage cells and release 8-hydroxydyoxyguanosine (8-OHdG) to serum. In this study, we evaluate the prevalence of H. pylori virulence factors and the association between serum level of 8-OHdG, H. pylori infection, and its various virulence factors...
November 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/28010892/implementation-and-evaluation-of-early-gastroscopy-for-patients-with-dyspepsia-and-warning-signs-in-primary-care
#13
Francisco Javier García-Alonso, María Hernández Tejero, Elvira Rubio Benito, Paz Valer, Iván Guerra, Victoria Gema García Ceballos, Mar Noguerol, Victoria Llinares, Fernando Bermejo
INTRODUCTION: Dyspepsia is a common disorder in both Primary (PC) and Specialised Care (SC). Gastroscopy is recommended at the start of the study if there are warning signs, although it is not always available in PC. OBJECTIVES AND METHODS: We developed a pilot project establishing an early gastroscopy programme for patients with dyspepsia and warning signs in PC, subsequently extending it to the entire healthcare area. The aim was to evaluate the requirements, impact and opinion of this service at the PC level...
December 20, 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28004533/new-olfactometric-findings-in-parkinson-s-disease
#14
Giulio Cesare Passali, Francesco Bove, Lucrezia Vargiu, Anna Rita Bentivoglio, Roberta Anzivino, Eugenio De Corso, Jacopo Galli, Mario Rigante, Manlio Pandolfini, Bruno Sergi, Monica Giuliani, Francesca Cianfrone, Gaetano Paludetti, Alfonso Fasano
OBJECTIVES: to investigate in Parkinson's Disease affected patients a correlation between hyposmia and gastrointestinal dysfunction and their possible identical etiopathogenesis. DESIGN: retrospective cohort study. SETTING: ENT and Neurology departments (Gemelli Hospital, Rome, Italy). PARTICIPANTS: 78 patients with diagnosis of PD according to the UK Brain Bank criteria. INCLUSION CRITERIA: informed consent; olfactory testing executed; exclusion criteria: signs of dementia according to the DSM-IV criteria; Mini Mental State Examination score ≤ 26; head trauma; central neurological disorders, nasal or systemic diseases potentially affecting olfactory function...
December 22, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27995404/circulating-zonulin-correlates-with-density-of-enteroviruses-and-tolerogenic-dendritic-cells-in-the-small-bowel-mucosa-of-celiac-disease-patients
#15
Tamara Vorobjova, Helerin Raikkerus, Lumme Kadaja, Ija Talja, Oivi Uibo, Kaire Heilman, Raivo Uibo
BACKGROUND: Impaired intestinal integrity, including increased permeability of the small bowel mucosa, has been shown in patients with celiac disease (CD) as well as with type 1 diabetes (T1D). Zonulin (ZO, pre-haptoglobin), a tight junction regulator, plays a particular role in the regulation of intestinal barrier function and in the pathogenesis of the above-mentioned diseases. AIM: To investigate whether enteroviruses (EVs) and immunoregulatory cells are associated with intestinal permeability in patients with CD alone and with coexistent T1D...
December 19, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27995399/low-yield-and-high-cost-of-gastric-and-duodenal-biopsies-for-investigation-of-symptoms-of-abdominal-pain-during-routine-esophagogastroduodenoscopy
#16
Eric M Nelsen, Abby Lochmann-Bailkey, Ian C Grimes, Mark E Benson, Deepak V Gopal, Patrick R Pfau
BACKGROUND: Esophagogastroduodenoscopy (EGD) referrals for symptoms of abdominal pain are common. Current guidelines for dyspepsia recommend biopsies of gastric mucosa for Helicobacter pylori in all patients referred for EGD. Our study aimed to determine the clinical yield and cost-effectiveness of gastric and duodenal biopsy in EGDs performed for abdominal pain. METHODS: Three hundred and ninety-one outpatient EGDs performed at a single academic tertiary care center were studied...
December 19, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27995392/abnormal-barrier-function-in-gastrointestinal-disorders
#17
Ricard Farré, María Vicario
There is increasing concern in identifying the mechanisms underlying the intimate control of the intestinal barrier, as deregulation of its function is strongly associated with digestive (organic and functional) and a number of non-digestive (schizophrenia, diabetes, sepsis, among others) disorders. The intestinal barrier is a complex and effective defensive functional system that operates to limit luminal antigen access to the internal milieu while maintaining nutrient and electrolyte absorption. Intestinal permeability to substances is mainly determined by the physicochemical properties of the barrier, with the epithelium, mucosal immunity, and neural activity playing a major role...
December 20, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27984597/neurofibroma-of-the-gallbladder-not-associated-with-neurofibromatosis
#18
Tsutomu Namikawa, Yasuhiro Kawanishi, Yuki Fujieda, Kazune Fujisawa, Eri Munekage, Masaya Munekage, Hiromichi Maeda, Hiroyuki Kitagawa, Michiya Kobayashi, Kazuhiro Hanazak
An 82-year-old woman had visited her local clinic with a history of abdominal discomfort and dyspepsia related to meals over a period of several months. Esophagogastroduodenoscopy revealed a superficial spreading tumor that, on biopsy, was proven to be an adenocarcinoma, and colonoscopy revealed an ascending mass that was found to be an adenocarcinoma on biopsy, so the patient was referred to our hospital. Abdominal computed tomography revealed a mass in the ascending colon with regional lymph node swelling and a gallbladder stone measuring 1...
December 16, 2016: Surgical Technology International
https://www.readbyqxmd.com/read/27977608/risk-factors-and-management-for-pyloric-stenosis-occurred-after-endoscopic-submucosal-dissection-adjacent-to-pylorus
#19
Jae Un Lee, Moon Sik Park, So Hee Yun, Min A Yang, Shang Hoon Han, Young Jae Lee, Gum Mo Jung, Ji Woong Kim, Yong Keun Cho, Jin Woong Cho
Endoscopic submucosal dissection (ESD) has been widely accepted as a curative treatment for gastric neoplasm. Pyloric stenosis is a chronic complication that can be caused by ESD. The aim of this study is to clarify the risk factors and management for pyloric stenosis. From January 2004 to January 2014, a total of 126 patients who underwent ESD adjacent to pylorus were reviewed retrospectively. Pyloric mucosal defect was defined as when any resection margin of ESD was involved in the pyloric ring. Pyloric stenosis was defined as when a conventional endoscope could not be passed to the duodenum...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27973922/minimal-differences-in-prevalence-and-spectrum-of-organic-disease-at-upper-gastrointestinal-endoscopy-between-selected-secondary-care-patients-with-symptoms-of-gastro-oesophageal-reflux-or-dyspepsia
#20
Andrew J Irvine, Maria Ines Pinto-Sanchez, Premysl Bercik, Paul Moayyedi, Alexander C Ford
OBJECTIVES: Gastro-oesophageal reflux and dyspepsia are felt to be separate upper gastrointestinal (GI) conditions. We aimed to measure the degree of overlap between them, and assess whether endoscopic findings differed. MATERIAL AND METHODS: Demographic, symptom, upper GI endoscopy and histology data were collected from consecutive adults in secondary care. Patients were categorised according to whether they reported gastro-oesophageal reflux alone, dyspepsia alone or both, and patient demographics and endoscopic findings were compared...
December 15, 2016: Scandinavian Journal of Gastroenterology
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