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https://www.readbyqxmd.com/read/30001732/the-central-mechanism-of-acupuncture-treatment-with-a-long-lasting-effect-for-functional-dyspepsia-study-protocol-for-a-randomized-controlled-trial
#1
Ruirui Sun, Xiaojuan Hong, Jing Guo, Shuai Yin, Peiming Feng, Lei Lan, Du Lei, Xiaoyan Liu, Xueling Suo, Tao Yin, Tingting Zhang, Liuyang Huang, Feifei Gao, Qiyong Gong, Fanrong Liang, Fang Zeng
BACKGROUND: The mechanism of the long-lasting effect and the relationship between the long-lasting effect and the deqi sensation, which is the key of achieving the acupuncture effect, has not been well investigated. This trial focuses on investigating the possible central mechanism of the long-lasting effect influenced by the deqi sensation. METHODS: A randomized controlled functional brain imaging trial is currently being conducted in Sichuan, China. In total 105 functional dyspepsia (FD) patients will be allocated into three groups: an acupuncture with deqi group, an acupuncture without deqi group, and a wait-list group...
July 13, 2018: Trials
https://www.readbyqxmd.com/read/29999489/helicobacter-pylori-infection
#2
Wolfgang Fischbach, Peter Malfertheiner
BACKGROUND: Infection with Helicobacter pylori (H. pylori) is a major pathogenic factor for gastroduodenal ulcer disease and gastric carcinoma, as well as for other types of gastric and extragastric disease. As a result of changing epidemiologic conditions (e.g., immigration), changing resistance patterns with therapeutic implications, and new knowledge relating to the indications for pathogen eradication, the medical management of H. pylori is a dynamic process in need of periodic reassessment...
June 22, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29992141/in-vivo-study-on-analgesic-muscle-relaxant-sedative-activity-of-extracts-of-hypochaeris-radicata-and-in-silico-evaluation-of-certain-compounds-present-in-this-species
#3
Tareq Abu-Izneid, Abdur Rauf, Syed Uzair Ali Shah, Abdul Wadood, Mohamed I S Abdelhady, Priymenko Nathalie, Domange Céline, Nashwa Mansour, Seema Patel
Background: Hypochaeris radicata (flatweed) from the family Asteraceae is a medicinal plant found in Europe, Middle East, and India. In folkloric medication, it is used to heal jaundice, dyspepsia, constipation, rheumatism, and hypoglycemia as well as renal problems. Leaves and roots of the plant have antioxidant and antibacterial properties. The plant is a rich source of pharmacologically active phytochemicals; however, it is explored scantily. The objective of the current study was to identify the chemical composition and investigate the in vivo biological potency of crude extracts of this plant...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29988618/gastric-mucosal-prolapse-a-case-of-proton-pump-inhibitor-nonresponsive-dyspepsia
#4
Tagore Sunkara, Emmanuel Ofori, Krishna Sowjanya Yarlagadda, Vinaya Gaduputi
Gastric mucosal prolapse (GMP) is a rare clinical syndrome that in patients with hiatal hernias and gastroesophageal reflux disease (GERD) may present with typical findings of abdominal pain and reflux symptoms but prove resistant to medical therapy. Physicians should therefore be aware and consider GMP as a differential in such patients in order to make an accurate diagnosis and provide timely treatment.
July 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29984202/dyspepsia-amongst-end-stage-renal-disease-undergoing-hemodialysis-views-from-a-large-tertiary-care-center
#5
Muhammad Ali Khalid, Jawaid Iqbal, Hassan Liaquat Memon, Farina M Hanif, Muhammad Osama Tariq Butt, Nasir Hassan Luck, Zain Majid
Background and Objectives: Gastrointestinal symptoms are common in patients with end stage renal disease (ESRD) among which dyspepsia is frequently observed. The aim of the study was to determine the frequency and associations of dyspepsia in ESRD patients using the Leeds questionnaire. Methods: All ESRD patients on maintenance hemodialysis were consecutively enrolled in the study. Leeds questionnaire was used to interrogate the patients for the assessment of dyspepsia...
June 2018: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29982192/proton-pump-inhibitors-and-suppression-of-duodenal-eosinophilia-in-functional-dyspepsia
#6
Michael D E Potter, Nicola K Wood, Marjorie M Walker, Michael P Jones, Nicholas J Talley
No abstract text is available yet for this article.
July 7, 2018: Gut
https://www.readbyqxmd.com/read/29979404/etiological-aspects-of-intragastric-bezoars-and-its-associations-to-the-gastric-function-implications-a-case-report-and-a-literature-review
#7
Samiullah Khan, Iftikhar-Ahmad Khan, Kifayat Ullah, Saima Khan, Xuan Wang, Lan-Ping Zhu, Mujeeb Ur Rehman, Xin Chen, Bang-Mao Wang
RATIONALE: Intragastric bezoar is a stony mass found trapped in the stomach, though it can occur in other locations of the gastro-intestinal tract. The etiology of intragastric bezoar is multifactorial, includes certain risk factors and predisposing factors such as coexisting medical disorders, anatomic abnormalities, and gastric motility disorders, which contribute to the development of intragastric bezoar. PATIENT CONCERNS: In this report, we present a rare case of intragastric bezoar with epigastric pain after prolonged consumption of jujubes...
July 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29977909/sleep-quality-of-functional-gastrointestinal-disorder-patients-in-class-three-hospitals-a-cross-sectional-study-in-tianjin-china
#8
Wei Zhao, Hong Jin, Mengque Xu, Dongxu Wang, Yandi Liu, Yanping Tang, Qiuzan Zhang, Jianping Hua, Bangmao Wang
Background: Functional gastrointestinal disorder (FGID) patients are influenced by anxiety, depression, and low sleep quality, which reduce the quality of their life. However, epidemiological data on the quality of sleep in FGID patients were lacking. This study aims to explore the sleep quality and influencing factors of the sleep quality in FGID patients. Methods: 1200 subjects, diagnosed as FGID in one of the six class-three hospitals in Tianjin, China, from January to December 2014, were recruited...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29976092/helicobacter-pylori-drug-resistance-therapy-changes-and-challenges
#9
Samantha Flores-Treviño, Soraya Mendoza-Olazarán, Paola Bocanegra-Ibarias, Héctor Jesús Maldonado-Garza, Elvira Garza-González
Helicobacter pylori is a Gram-negative bacterium that causes chronic gastritis, dyspepsia, peptic ulcers and gastric cancer. Over half the world's population is infected with H. pylori, with higher prevalence in developing countries. Areas covered: In this review, current guidelines on H. pylori therapy, such as the Toronto consensus statement, the Maastricht V/Florence consensus report and the American College of Gastroenterology guidelines are compared. Also, we analyzed reports of antimicrobial resistance of H...
July 5, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29969861/relation-of-enteric-%C3%AE-synuclein-to-gastrointestinal-dysfunction-in-patients-with-parkinson-s-disease-and-in-neurologically-intact-subjects
#10
Hyo Jeong Lee, Kee Wook Jung, Sun Ju Chung, Seung-Mo Hong, Juyeon Kim, Jeong Hoon Lee, Sung Wook Hwang, Ho-Sung Ryu, Mi Jung Kim, Ho-Su Lee, Myeongsook Seo, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Jaewon Choe, Hwoon-Yong Jung, Suk-Kyun Yang, Seung-Jae Myung
Background/Aims: α-Synucleinopathy in the brain is the neuropathological hallmark of Parkinson's disease (PD). However, the functional impact of α-synucleinopathy in the enteric nervous system remains unknown. We aim to evaluate the association between gastrointestinal (GI) dysfunction and α-synuclein (αSYN) pathology in the stomach and colon of PD patients and controls, as well as to investigate the association between the αSYN pathology in GI tract and future PD risk. Methods: A total of 35 PD patients and 52 neurologically intact subjects were enrolled in this study...
July 30, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29963454/primary-gastric-lymphoma-clinicopathological-profile
#11
Renuka Malipatel, Mallikarjun Patil, Patil Pritilata Rout, Marjorie Correa, Harshad Devarbhavi
Introduction: Gastrointestinal tract (GIT) is the most common site of involvement of extranodal non-Hodgkin's lymphoma (NHL). There is regional variation in anatomical distribution of extranodal NHL, stomach being the most common site followed by small intestine. Primary gastric lymphoma (PGL) predominantly involves the antrum and corpus of the stomach. It arises from mucosa-associated lymphoid tissue (MALT) and is of B-cell lineage and often associated with Helicobacter pylori infection...
January 2018: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29960971/ayurveda-metallic-mineral-bhasma-associated-severe-liver-injury
#12
Cyriac Abby Philips, Rajaguru Paramaguru, Philip Augustine
Ayurveda Bhasma is a metallic-mineral preparation homogenised with herbal juices or decoctions and modified with heat treatment to apparently detoxify the heavy metals. It is widely recommended for the treatment of many disease conditions by practitioners of complementary and alternative medicine in the absence of good quality clinical trial evidence on its safety and efficacy. Heavy metal-induced liver injury is widely reported in the literature, and heavy metal adulteration of non-Bhasma-related Ayurveda and herbal products has been well described...
June 29, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29960957/phytobezoar-and-duodenal-ulcer-as-complication-of-duodopa-therapy-in-a-patient-affected-by-parkinson-s-disease
#13
Paolo Cerrone, Michele Marchese, Maria Antonietta Pistoia, Carmine Marini
Continuous duodenal infusion of levodopa/carbidopa intestinal gel (LCIG) is an established treatment to control motor fluctuations in Parkinson's disease. Duodenal infusion allows a steady absorption of the drug in the small bowel, reducing plasmatic fluctuations of levodopa. Some complications may occur during the treatment, often related to intrajejunal percutaneous endoscopic gastrostomy (PEG-J). We report a case of duodenal ulcer associated with a phytobezoar involving the end of jejunal probe, in a patient who underwent PEG-J for LCIG infusion...
June 29, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29956418/the-biology-first-hypothesis-functional-disorders-may-begin-and-end-with-biology-a-scoping-review
#14
P Enck, N Mazurak
While it is generally accepted that gastrointestinal infections can cause functional disturbances in the upper and lower gastrointestinal tract-known as postinfectious irritable bowel syndrome (PI-IBS) and functional dyspepsia (PI-FD)-it has still not been widely recognized that such an infection can also initiate functional non-intestinal diseases, and that non-intestinal infections can provoke both intestinal and non-intestinal functional disturbances. We conducted a scoping review of the respective literature and-on the basis of these data-hypothesize that medically unexplained functional symptoms and syndromes following an infection may have a biological (genetic, endocrine, microbiological) origin, and that psychological and social factors, which may contribute to the disease "phenotype," are secondary to this biological cause...
June 28, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29941708/a-randomized-double-blind-multicenter-placebo-controlled-trial-of-qi-zhi-wei-tong-granules-on-postprandial-distress-syndrome-predominant-functional-dyspepsia
#15
Qing Su, Sheng-Liang Chen, Hua-Hong Wang, Lie-Xin Liang, Ning Dai, Bin Lyu, Jun Zhang, Rong-Quan Wang, Ya-Li Zhang, Yue Yu, Jin-Song Liu, Xiao-Hua Hou
Background: Functional dyspepsia (FD) is a common upper gastrointestinal disorder worldwide, but the current treatments for FD are still unsatisfactory. The aims of this study were to investigate the efficacy and safety of Qi-Zhi-Wei-Tong granules in patients with postprandial distress syndrome (PDS)-predominant FD. Methods: The study was conducted as a randomized, double-blinded, multicenter, placebo-controlled design in 197 patients with PDS. All participants received placebo treatment for 1 week...
July 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29938463/prevalence-and-risk-factors-of-functional-dyspepsia-in-health-check-up-population-a-nationwide-multicenter-prospective-study
#16
Sung Eun Kim, Nayoung Kim, Ju Yup Lee, Kyung Sik Park, Jeong Eun Shin, Kwangwoo Nam, Hyeon Ju Kim, Hyun Joo Song, Young-Eun Joo, Dae-Seong Myung, Ji-Hyun Seo, Hyun Jin Jo, Seon Mie Kim, Seon Hee Lim, Hyun Jin Kim, Gwang Ho Baik, Sang Hyeon Choi, Suck Chei Choi
Background/Aims: Functional dyspepsia (FD) is one of the most common gastrointestinal disorders, and FD imposes social and economic burden worldwide. The aim of this study was to identify the prevalence and risk factors of FD in health check-up population in tertiary centers in Korea. Methods: A nationwide multicenter prospective study was performed at 9 tertiary healthcare centers in Korea between September 2016 and June 2017. A total of 2525 subjects were investigated based on endoscopic findings and questionnaires with Rome III criteria, and Helicobacter pylori serology (IgG)...
June 23, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29938452/efficacy-and-safety-of-ui05msp015ct-in-functional-dyspepsia-a-randomized-controlled-trial
#17
Hyuk Yoon, Dong Ho Lee, Yong-Hyun Lee, Ju-Cheol Jeong, Soo Teik Lee, Myung-Gyu Choi, Seong Woo Jeon, Ki-Nam Shim, Gwang Ho Baik, Jae Gyu Kim, Jeong Seop Moon, In-Kyung Sung, Sang Kil Lee, Poong-Lyul Rhee, Hwoon-Yong Jung, Bong Eun Lee, Hyun Soo Kim, Sang Gyun Kim, Kee Myung Lee, Jae Kyu Seong, Jin Seok Jang, Jong-Jae Park
Background/Aims: To evaluate the efficacy and safety of a controlled release, once-daily formulation of mosapride (UI05MSP015CT) in patients with functional dyspepsia (FD). Methods: Patients with FD were randomly assigned (1:1) to receive either UI05MSP015CT (15 mg once a day, study group) or mosapride (5 mg three times a day, control group) and corresponding placebo for 4 weeks. The primary endpoint was a change in the gastrointestinal symptom score (GIS) evaluated at enrollment and after 4 weeks...
June 22, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29933411/time-trends-in-dyspepsia-and-association-with-h-pylori-and-work-related-stress-an-observational-study-in-white-collar-employees-in-1996-and-2015
#18
Stefanie Braig, Simon Berger, David Rothenbacher, Stefanie Schmid, Thomas Seufferlein, Hermann Brenner, Dietrich Rothenbacher, Harald Gündel
PURPOSE: We aimed to describe time trends in functional dyspepsia and the association of dyspepsia-related factors, Helicobacter pylori (H. pylori) and work-related stress with functional dyspepsia in white collar employees in 1996 and 2015. MATERIALS AND METHODS: Repeat cross-sectional study conducted in 1996 (n = 190, response rate = 76.1) and 2015 (n = 195, response rate = 40.2) within a health insurance company in South-West Germany. Dyspeptic symptoms measured according to the Rome III criteria, effort-reward imbalance and further work- or dyspepsia-related factors were assessed by self-administered questionnaire...
2018: PloS One
https://www.readbyqxmd.com/read/29928161/the-role-of-proton-pump-inhibitors-in-the-management-of-upper-gastrointestinal-disorders
#19
Muhammad Ali Khan, Colin W Howden
Proton pump inhibitors (PPIs) have been in use since the early 1990s and play a crucial role in the management of a number of conditions affecting the upper gastrointestinal tract, including gastroesophageal reflux disease, Barrett esophagus, eosinophilic esophagitis, and dyspepsia. PPIs also play an important role in the treatment of Helicobacter pylori infection and in the prevention of upper gastrointestinal tract ulcers and bleeding among patients taking antiplatelet therapy and/or nonsteroidal anti-inflammatory drugs...
March 2018: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29924294/fat-label-compared-with-fat-content-gastrointestinal-symptoms-and-brain-activity-in-functional-dyspepsia-patients-and-healthy-controls
#20
In-Seon Lee, Stephanie Kullmann, Klaus Scheffler, Hubert Preissl, Paul Enck
Background: High-fat meals are associated with dyspeptic symptoms in functional dyspepsia (FD) patients. It is still unclear how fat is processed, or how FD symptoms and neuronal activities are modulated by psychological factors. Objective: We investigated brain activity by functional magnetic resonance imaging (fMRI) after the ingestion of high- and low-fat foods with correct/incorrect fat information. Design: We compared 12 FD patients and 14 healthy controls (HCs)...
June 18, 2018: American Journal of Clinical Nutrition
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