Soroush Mirkiani, Carly L O'Sullivan, David A Roszko, Pouria Faridi, David S Hu, Dirk G Everaert, Amirali Toossi, Ryan Kang, Tongzhou Fang, Neil Tyreman, Ashley N Dalrymple, Kevin Robinson, Richard R E Uwiera, Hamid Shah, Richard Fox, Peter E Konrad, Vivian K Mushahwar
OBJECTIVE: The goal of this study was to assess the safety of mapping spinal cord locomotor networks using penetrating stimulation microelectrodes in Yucatan minipigs (YMPs) as a clinically translational animal model. METHODS: Eleven YMPs were trained to walk up and down a straight line. Motion capture was performed, and electromyographic (EMG) activity of hindlimb muscles was recorded during overground walking. The YMPs underwent a laminectomy and durotomy to expose the lumbar spinal cord...
May 10, 2024: Journal of Neurosurgery. Spine