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Training performance modeling

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https://www.readbyqxmd.com/read/29779177/computational-identification-of-structural-factors-affecting-the-mutagenic-potential-of-aromatic-amines-study-design-and-experimental-validation
#1
Svetoslav H Slavov, Iva Stoyanova-Slavova, William Mattes, Richard D Beger, Beat J Brüschweiler
A grid-based, alignment-independent 3D-SDAR (three-dimensional spectral data-activity relationship) approach based on simulated 13 C and 15 N NMR chemical shifts augmented with through-space interatomic distances was used to model the mutagenicity of 554 primary and 419 secondary aromatic amines. A robust modeling strategy supported by extensive validation including randomized training/hold-out test set pairs, validation sets, "blind" external test sets as well as experimental validation was applied to avoid over-parameterization and build Organization for Economic Cooperation and Development (OECD 2004) compliant models...
May 19, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29779153/intraoperative-stent-segmentation-in-x-ray-fluoroscopy-for-endovascular-aortic-repair
#2
Katharina Breininger, Shadi Albarqouni, Tanja Kurzendorfer, Marcus Pfister, Markus Kowarschik, Andreas Maier
PURPOSE: Fusion of preoperative data with intraoperative X-ray images has proven the potential to reduce radiation exposure and contrast agent, especially for complex endovascular aortic repair (EVAR). Due to patient movement and introduced devices that deform the vasculature, the fusion can become inaccurate. This is usually detected by comparing the preoperative information with the contrasted vessel. To avoid repeated use of iodine, comparison with an implanted stent can be used to adjust the fusion...
May 19, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29778857/development-of-a-risk-score-based-on-aortic-calcification-to-predict-1-year-mortality-after-transcatheter-aortic-valve-replacement
#3
Pierre Lantelme, Hélène Eltchaninoff, Muriel Rabilloud, Géraud Souteyrand, Marion Dupré, Marco Spaziano, Marc Bonnet, Clément Becle, Benjamin Riche, Eric Durand, Erik Bouvier, Jean-Nicolas Dacher, Pierre-Yves Courand, Lucie Cassagnes, Eduardo E Dávila Serrano, Pascal Motreff, Loic Boussel, Thierry Lefèvre, Brahim Harbaoui
OBJECTIVES: The aim of this study was to develop a new scoring system based on thoracic aortic calcification (TAC) to predict 1-year cardiovascular and all-cause mortality. BACKGROUND: A calcified aorta is often associated with poor prognosis after transcatheter aortic valve replacement (TAVR). A risk score encompassing aortic calcification may be valuable in identifying poor TAVR responders. METHODS: The C4 CAPRI (4 Cities for Assessing CAlcification PRognostic Impact) multicenter study included a training cohort (1,425 patients treated using TAVR between 2010 and 2014) and a contemporary test cohort (311 patients treated in 2015)...
May 11, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29778804/emotion-introspection-and-regulation-in-depression
#4
Uwe Herwig, Sarah Opialla, Katja Cattapan, Thomas C Wetter, Lutz Jäncke, Annette B Brühl
Depressed patients suffer from an impairment to voluntarily influence and regulate their unpleasant emotional state. Strengthening the mental ability to interfere with dysfunctional emotion processing may be beneficial in treating depression. According to models of emotion processing this may be done by successful down-regulation of enhanced amygdala activity. We investigated short periods of intentional emotion-introspection compared with cognitive self-reflection as two domains of self-awareness in terms of effects on emotion regulation...
May 9, 2018: Psychiatry research. Neuroimaging
https://www.readbyqxmd.com/read/29777650/modeling-dengue-vector-population-using-remotely-sensed-data-and-machine-learning
#5
Juan M Scavuzzo, Francisco Trucco, Manuel Espinosa, Carolina B Tauro, Marcelo Abril, Carlos M Scavuzzo, Alejandro C Frery
Mosquitoes are vectors of many human diseases. In particular, Aedes ægypti (Linnaeus) is the main vector for Chikungunya, Dengue, and Zika viruses in Latin America and it represents a global threat. Public health policies that aim at combating this vector require dependable and timely information, which is usually expensive to obtain with field campaigns. For this reason, several efforts have been done to use remote sensing due to its reduced cost. The present work includes the temporal modeling of the oviposition activity (measured weekly on 50 ovitraps in a north Argentinean city) of Aedes ægypti (Linnaeus), based on time series of data extracted from operational earth observation satellite images...
May 16, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29777147/prediction-of-moisture-content-for-congou-black-tea-withering-leaves-using-image-features-and-nonlinear-method
#6
Gaozhen Liang, Chunwang Dong, Bin Hu, Hongkai Zhu, Haibo Yuan, Yongwen Jiang, Guoshuang Hao
Withering is the first step in the processing of congou black tea. With respect to the deficiency of traditional water content detection methods, a machine vision based NDT (Non Destructive Testing) method was established to detect the moisture content of withered leaves. First, according to the time sequences using computer visual system collected visible light images of tea leaf surfaces, and color and texture characteristics are extracted through the spatial changes of colors. Then quantitative prediction models for moisture content detection of withered tea leaves was established through linear PLS (Partial Least Squares) and non-linear SVM (Support Vector Machine)...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29776359/evaluation-of-malaria-rapid-diagnostic-test-rdt-use-by-community-health-workers-a-longitudinal-study-in-western-kenya
#7
Matthew R Boyce, Diana Menya, Elizabeth L Turner, Jeremiah Laktabai, Wendy Prudhomme-O'Meara
BACKGROUND: Malaria rapid diagnostic tests (RDTs) are a simple, point-of-care technology that can improve the diagnosis and subsequent treatment of malaria. They are an increasingly common diagnostic tool, but concerns remain about their use by community health workers (CHWs). These concerns regard the long-term trends relating to infection prevention measures, the interpretation of test results and adherence to treatment protocols. This study assessed whether CHWs maintained their competency at conducting RDTs over a 12-month timeframe, and if this competency varied with specific CHW characteristics...
May 18, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29776069/accelerating-simulation-for-the-multiple-point-statistics-algorithm-using-vector-quantization
#8
Chen Zuo, Zhibin Pan, Hao Liang
Multiple-point statistics (MPS) is a prominent algorithm to simulate categorical variables based on a sequential simulation procedure. Assuming training images (TIs) as prior conceptual models, MPS extracts patterns from TIs using a template and records their occurrences in a database. However, complex patterns increase the size of the database and require considerable time to retrieve the desired elements. In order to speed up simulation and improve simulation quality over state-of-the-art MPS methods, we propose an accelerating simulation for MPS using vector quantization (VQ), called VQ-MPS...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29775986/effects-of-two-training-programs-on-transcriptional-levels-of-neurotrophins-and-glial-cells-population-in-hippocampus-of-experimental-multiple-sclerosis
#9
Maryam Naghibzadeh, Rouhollah Ranjbar, Mohammad Reza Tabandeh, Abdolhamid Habibi
The aim of the present study was to investigate the effects of high-intensity interval training (HIIT) versus low-intensity continuous training (LICT) on transcriptional levels of neurotrophic factors and oligodendrocyte/microglia cell loss in a cuprizone (CP) induced animal model of demyelination. Male C57BL/6 mice were assigned to six groups: control (C), cuprizone-induced demyelination (CP), interval training (IT), continuous training (CT), IT plus CP (ITCP), and CT plus CP (CTCP). Training programs on the treadmill were performed for four weeks, and then demyelination was induced by feeding mice a diet containing 0...
May 18, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29775287/computational-prediction-and-analysis-for-tyrosine-post-translational-modifications-via-elastic-net
#10
Man Cao, Guodong Chen, Lina Wang, Pingping Wen, Shaoping Shi
The tyrosine residue has been identified as suffering three major post-translational modifications (PTMs) including nitration, sulfation, and phosphorylation, which could be involved in different physiological and pathological processes. Multiple tyrosine residues of the whole protein may be modified concurrently, where PTM of a single tyrosine may affect modification of other neighboring tyrosine residues. Hence, it is significant and beneficial to predict nitration, sulfation, and phosphorylation of tyrosine residues in the whole protein sequence...
May 18, 2018: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29773659/modeling-leaderless-transcription-and-atypical-genes-results-in-more-accurate-gene-prediction-in-prokaryotes
#11
Alexandre Lomsadze, Karl Gemayel, Shiyuyun Tang, Mark Borodovsky
In a conventional view of the prokaryotic genome organization, promoters precede operons and RBS sites with Shine-Dalgarno consensus precede genes. However, recent experimental research suggesting a more diverse view motivated us to develop an algorithm with improved gene-finding accuracy. We describe GeneMarkS 2, an ab initio algorithm that uses a model derived by self-training for finding species-specific (native) genes, along with an array of pre-computed "heuristic" models designed to identify harder-to-detect genes (likely horizontally transferred)...
May 17, 2018: Genome Research
https://www.readbyqxmd.com/read/29772901/the-catch-22-of-predicting-herg-blockade-using-publicly-accessible-bioactivity-data
#12
Vishal Babu Siramshetty, Qiaofeng Chen, Prashanth Devarakonda, Robert Preissner
Drug-induced inhibition of the human Ether-à-go-go-Related Gene (hERG) encoded potassium ion (K+) channels can lead to fatal cardiotoxicity. Several marketed drugs and promising drug candidates were recalled due to this concern. Diverse modeling methods ranging from molecular similarity assessment to quantitative structure activity relationship analysis employing machine learning techniques have been applied to datasets of varying size and composition (number of blockers and non-blockers). In this study, we highlight the challenges involved in development of a robust classifier for predicting the hERG endpoint using bioactivity data extracted from the public domain...
May 17, 2018: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29772392/effects-of-task-repetition-but-no-transfer-of-inhibitory-control-training-in-healthy-adults
#13
Tobias Talanow, Ulrich Ettinger
Executive functions (EFs) comprise the updating, shifting and inhibition dimensions. According to the Unity and Diversity Model, the inhibition dimension is fully accounted for by a general EFs factor. This suggests that training of inhibition should transfer, in part, to updating and shifting. Therefore, we tested the effectiveness of a three-week inhibition training (high-conflict Stroop task) and explored near transfer effects to an untrained inhibition task (antisaccade task) and far transfer effects to untrained tasks demanding task-set shifting (number-letter-task), working memory updating (n-back task) and planning abilities (Stockings of Cambridge task)...
May 14, 2018: Acta Psychologica
https://www.readbyqxmd.com/read/29771987/visualization-of-gender-race-citizenship-and-academic-performance-in-association-with-career-outcomes-of-15-year-biomedical-doctoral-alumni-at-a-public-research-university
#14
Ambika Mathur, Annmarie Cano, Michael Kohl, Nisansala S Muthunayake, Prassanna Vaidyanathan, Mary E Wood, Mustafa Ziyad
It has long been thought that biomedical doctoral students pursue careers primarily as tenure-track/tenured faculty at research institutions. Recent reports showed, however, that the majority of biomedical doctoral alumni engage in a variety of careers. Wayne State University (WSU) undertook a project to understand the career trajectories of its biomedical doctoral alumni to create programs to better prepare its students for careers in multiple pathways. Data were collected on career outcomes of WSU's biomedical doctoral alumni who graduated in a 15-year period from 1999-2014...
2018: PloS One
https://www.readbyqxmd.com/read/29771930/perspectives-of-human-verification-via-binary-qrs-template-matching-of-single-lead-and-12-lead-electrocardiogram
#15
Vessela Krasteva, Irena Jekova, Ramun Schmid
OBJECTIVE: This study aims to validate the 12-lead electrocardiogram (ECG) as a biometric modality based on two straightforward binary QRS template matching characteristics. Different perspectives of the human verification problem are considered, regarding the optimal lead selection and stability over sample size, gender, age, heart rate (HR). METHODS: A clinical 12-lead resting ECG database, including a population of 460 subjects with two-session recordings (>1 year apart) is used...
2018: PloS One
https://www.readbyqxmd.com/read/29771160/effects-of-an-intervention-program-for-pomoting-ethical-practices-among-pediatric-nurses
#16
Naomi Matsumori
The Japanese nursing education system only requires a general nursing qualification. After graduation, many Japanese nurses work within pediatric departments where they receive specialized training in pediatric care. An intervention program for promoting ethical nursing practices among patients and their families was implemented for pediatric nurses with 0-5 years pediatric nursing experience. The objective of this study was to clarify changes in nurses' recognition and behaviors, as well as the intervention's post-initiation durability...
May 17, 2018: Comprehensive Child and Adolescent Nursing
https://www.readbyqxmd.com/read/29770249/snorkel-rapid-training-data-creation-with-weak-supervision
#17
Alexander Ratner, Stephen H Bach, Henry Ehrenberg, Jason Fries, Sen Wu, Christopher Ré
Labeling training data is increasingly the largest bottleneck in deploying machine learning systems. We present Snorkel, a first-of-its-kind system that enables users to train state-of- the-art models without hand labeling any training data. Instead, users write labeling functions that express arbitrary heuristics, which can have unknown accuracies and correlations. Snorkel denoises their outputs without access to ground truth by incorporating the first end-to-end implementation of our recently proposed machine learning paradigm, data programming...
November 2017: Proceedings of the VLDB Endowment
https://www.readbyqxmd.com/read/29769059/a-mooc-as-an-immediate-strategy-to-train-health-personnel-in-the-cholera-outbreak-in-mexico
#18
Laura Magaña-Valladares, Cynthia Rosas-Magallanes, Alejandra Montoya-Rodríguez, Guillermo Calvillo-Jacobo, Celia Mercedes Alpuche-Arande, Sebastían García-Saisó
BACKGROUND: In September 2013, two cases of cholera were reported in Mexico; 1 week later, a new outbreak was reported in the Huasteca region of Hidalgo. Upon the determination that the diagnostic and therapeutic interventions implemented by health personnel overlooked predefined procedures, the National Institute of Public Health, in coordination with the Ministry of Health, immediately designed the massive open online course "Proper cholera containment and management measures" to strengthen and standardize basic prevention and control practices...
May 16, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29769007/qsar-and-docking-studies-on-piperidyl-cyclohexylurea-derivatives-for-prediction-of-selective-and-potent-inhibitor-of-matriptase
#19
Agha Zeeshan Mirza, Hina Shamshad
QSAR models as PLS, GFA, and 3D were developed for series of matriptase inhibitors using 35 piperidyl-cyclohexylurea compounds. The training and test sets were divided into a set of 28 and 8 compounds, respectively and the pki values of each compound were used in the analysis. Docking and alignment methodologies were used to develop models in 3D QSAR. The best models among all were selected on the basis of regression statistics as r2, predictive r2 and Friedman Lack of fit measure. Hydrogen donors and rotatable bonds were found to be positively correlated properties for this target...
May 16, 2018: Current Computer-aided Drug Design
https://www.readbyqxmd.com/read/29767225/effect-of-balance-training-on-the-falling-in-osteoporosis-patients-a-systematic-review-and-meta-analysis
#20
Xin Zhou, Hui Ding, Xiaoping Shen, Zingliang Lei
BACKGROUND: Balance training may be beneficial for patients with osteoporosis, although current results are inconclusive. The aim of this systematic review and meta-analysis was to explore the effect of balance training on falls in patients with osteoporosis. METHODS: PubMed, Embase, Web of Science, EBSCO, and Cochrane Library databases were systematically searched. Randomized controlled trials (RCTs) assessing the effect of balance training vs usual activities on falls in patients with osteoporosis were included...
May 16, 2018: Journal of Rehabilitation Medicine
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