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https://www.readbyqxmd.com/read/28110245/bipartite-network-analysis-reveals-metabolic-gene-expression-profiles-that-are-highly-associated-with-the-clinical-outcomes-of-acute-myeloid-leukemia
#1
Fanfan Xie, Mingxiong He, Li He, Keqin Liu, Menglong Li, Guoquan Hu, Zhining Wen
Dysregulated and reprogrammed metabolism are one of the most important characteristics of cancer, and exploiting cancer cell metabolism can aid in understanding the diverse clinical outcomes for patients. To investigate the differences in metabolic pathways among patients with acute myeloid leukemia (AML) and differential survival outcomes, we systematically conducted microarray data analysis of the metabolic gene expression profiles from 384 patients available from the Gene Expression Omnibus and Cancer Genome Atlas databases...
January 6, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28108975/3d-printed-soft-tissue-physical-models-of-renal-malignancies-for-individualized-surgical-simulation-a-feasibility-study
#2
Michael M Maddox, Allison Feibus, James Liu, Julie Wang, Raju Thomas, Jonathan L Silberstein
To construct patient-specific physical three-dimensional (3D) models of renal units with materials that approximates the properties of renal tissue to allow pre-operative and robotic training surgical simulation, 3D physical kidney models were created (3DSystems, Rock Hill, SC) using computerized tomography to segment structures of interest (parenchyma, vasculature, collection system, and tumor). Images were converted to a 3D surface mesh file for fabrication using a multi-jet 3D printer. A novel construction technique was employed to approximate normal renal tissue texture, printers selectively deposited photopolymer material forming the outer shell of the kidney, and subsequently, an agarose gel solution was injected into the inner cavity recreating the spongier renal parenchyma...
January 20, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28108896/pharmacophore-based-screening-and-drug-repurposing-exemplified-on-glycogen-synthase-kinase-3-inhibitors
#3
Luminita Crisan, Sorin Avram, Liliana Pacureanu
The current study was conducted to elaborate a novel pharmacophore model to accurately map selective glycogen synthase kinase-3 (GSK-3) inhibitors, and perform virtual screening and drug repurposing. Pharmacophore modeling was developed using PHASE on a data set of 203 maleimides. Two benchmarking validation data sets with focus on selectivity were assembled using ChEMBL and PubChem GSK-3 confirmatory assays. A drug repurposing experiment linking pharmacophore matching with drug information originating from multiple data sources was performed...
January 21, 2017: Molecular Diversity
https://www.readbyqxmd.com/read/28108009/which-factors-are-most-predictive-for-live-birth-after-in%C3%A2-vitro-fertilization-and-intracytoplasmic-sperm-injection-ivf-icsi-treatments-analysis-of-100-prospectively-recorded-variables-in-8-400-ivf-icsi-single-embryo-transfers
#4
Katarina Kebbon Vaegter, Tatevik Ghukasyan Lakic, Matts Olovsson, Lars Berglund, Thomas Brodin, Jan Holte
OBJECTIVE: To construct a prediction model for live birth after in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment and single-embryo transfer (SET) after 2 days of embryo culture. DESIGN: Prospective observational cohort study. SETTING: University-affiliated private infertility center. PATIENT(S): SET in 8,451 IVF/ICSI treatments in 5,699 unselected consecutive couples during 1999-2014. INTERVENTION(S): A total of 100 basal patient characteristics and treatment data were analyzed for associations with live birth after IVF/ICSI (adjusted for repeated treatments) and subsequently combined for prediction model construction...
January 6, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28107486/determinants-of-cervical-cancer-screening-accuracy-for-visual-inspection-with-acetic-acid-via-and-lugol-s-iodine-vili-performed-by-nurse-and-physician
#5
Amidu O Raifu, Mariam El-Zein, Ghislain Sangwa-Lugoma, Agnihotram Ramanakumar, Stephen D Walter, Eduardo L Franco
BACKGROUND: Visual inspection with acetic acid (VIA) and Lugol's iodine (VILI) are used to screen women for cervical cancer in low-resource settings. Little is known about correlates of their diagnostic accuracy by healthcare provider. We examined determinants of VIA and VILI screening accuracy by examiner in a cross-sectional screening study of 1528 women aged 30 years or older in a suburb of Kinshasa, Democratic Republic of Congo. METHODS: We used a logistic regression model for sensitivity and specificity to estimate the diagnostic accuracy of VIA and VILI, independently performed by nurse and physician, as a function of sociodemographic and reproductive health characteristics...
2017: PloS One
https://www.readbyqxmd.com/read/28106418/spatiotemporal-dynamics-and-reliable-computations-in-recurrent-spiking-neural-networks
#6
Ryan Pyle, Robert Rosenbaum
Randomly connected networks of excitatory and inhibitory spiking neurons provide a parsimonious model of neural variability, but are notoriously unreliable for performing computations. We show that this difficulty is overcome by incorporating the well-documented dependence of connection probability on distance. Spatially extended spiking networks exhibit symmetry-breaking bifurcations and generate spatiotemporal patterns that can be trained to perform dynamical computations under a reservoir computing framework...
January 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28106247/validation-of-the-nccn-ipi-for-diffuse-large-b-cell-lymphoma-dlbcl-the-addition-of-%C3%AE-2-microglobulin-yields-a-more-accurate-geltamo-ipi
#7
Carlos Montalbán, Antonio Díaz-López, Ivan Dlouhy, Jordina Rovira, Armando Lopez-Guillermo, Sara Alonso, Alejandro Martín, Juan M Sancho, Olga García, Jose M Sánchez, Mario Rodríguez, Silvana Novelli, Antonio Salar, Antonio Gutiérrez, Maria J Rodríguez-Salazar, Mariana Bastos, Juan F Domínguez, Rubén Fernández, Sonia Gonzalez de Villambrosia, José A Queizan, Raul Córdoba, Raquel de Oña, Andrés López-Hernandez, Julian M Freue, Heidys Garrote, Lourdes López, Ana M Martin-Moreno, Jose Rodriguez, Víctor Abraira, Juan F García
The study included 1848 diffuse large B-cell lymphoma (DLBCL)patients treated with chemotherapy/rituximab. The aims were to validate the National Comprehensive Cancer Network International Prognostic Index (NCCN-IPI) and explore the effect of adding high Beta-2 microglobulin (β2M), primary extranodal presentation and intense treatment to the NCCN-IPI variables in order to develop an improved index. Comparing survival curves, NCCN-IPI discriminated better than IPI, separating four risk groups with 5-year overall survival rates of 93%, 83%, 67% and 49%, but failing to identify a true high-risk population...
January 20, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28105958/dmirnet-inferring-direct-microrna-mrna-association-networks
#8
Minsu Lee, HyungJune Lee
BACKGROUND: MicroRNAs (miRNAs) play important regulatory roles in the wide range of biological processes by inducing target mRNA degradation or translational repression. Based on the correlation between expression profiles of a miRNA and its target mRNA, various computational methods have previously been proposed to identify miRNA-mRNA association networks by incorporating the matched miRNA and mRNA expression profiles. However, there remain three major issues to be resolved in the conventional computation approaches for inferring miRNA-mRNA association networks from expression profiles...
December 5, 2016: BMC Systems Biology
https://www.readbyqxmd.com/read/28105617/-establishment-of-prediction-model-of-acute-gastrointestinal-injury-classification-of-critically-ill-patients-based-on-digital-gastrointestinal-sounds-monitoring
#9
Yan Wang, Jianrong Wang, Weiwei Liu, Guangliang Zhang
OBJECTIVE: To develop the prediction model of acute gastrointestinal injury (AGI) classification of critically ill patients. METHODS: The binary channel gastrointestinal sounds (GIS) monitor system was used to gather and analyze the GIS of 60 consecutive critically ill patients who were admitted in Critical Care Medicine of PLA General Hospital from April 2015 to November 2015 (patients with chronic gastrointestinal disease or history of gastrointestinal surgery were excluded)...
January 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28104550/robust-estimation-of-carotid-artery-wall-motion-using-the-elasticity-based-state-space-approach
#10
Zhifan Gao, Huahua Xiong, Xin Liu, Heye Zhang, Dhanjoo Ghista, Wanqing Wu, Shuo Li
The dynamics of the carotid artery wall has been recognized as a valuable indicator to evaluate the status of atherosclerotic disease in the preclinical stage. However, it is still a challenge to accurately measure this dynamics from ultrasound images. This paper aims at developing an elasticity-based state-space approach for accurately measuring the two-dimensional motion of the carotid artery wall from the ultrasound imaging sequences. In our approach, we have employed a linear elasticity model of the carotid artery wall, and converted it into the state space equation...
January 10, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28104403/a-model-to-predict-risk-of-blood-transfusion-after-gynecologic-surgery
#11
Jamie Stanhiser, Kevin Chagin, J Eric Jelovsek
BACKGROUND: A model that predicts a patient's risk of receiving a blood transfusion may facilitate selective preoperative testing and more efficient perioperative blood management utilization. OBJECTIVES: To construct and validate a model that predicts a patient's risk of receiving a blood transfusion after gynecologic surgery. STUDY DESIGN: 18,319 women who underwent gynecologic surgery at 10 institutions in a single health system by 116 surgeons between January 2010 and June 2014 were analyzed...
January 16, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28103737/a-multidimensional-approach-to-performance-prediction-in-olympic-distance-cross-country-mountain-bikers
#12
Andrew R Novak, Kyle J M Bennett, Job Fransen, Ben J Dascombe
This study adopted a multidimensional approach to performance prediction within Olympic distance cross-country mountain biking (XCO-MTB). Twelve competitive XCO-MTB cyclists (VO2max 60.8 ± 6.7 ml · kg(-1)( )· min(-1)) completed an incremental cycling test, maximal hand grip strength test, cycling power profile (maximal efforts lasting 6-600 s), decision-making test and an individual XCO-MTB time-trial (34.25 km). A hierarchical approach using multiple linear regression analyses was used to develop predictive models of performance across 10 circuit subsections and the total time-trial...
January 20, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28103562/a-decision-support-system-for-tele-monitoring-copd-related-worrisome-events
#13
Mario Merone, Claudio Pedone, Giuseppe Capasso, Raffaele Antonelli Incalzi, Paolo Soda
Chronic Obstructive Pulmonary Disease (COPD) is a preventable, treatable and slowly progressive disease, whose course is aggravated by a periodic worsening of symptoms and lung function lasting for several days. The development of home telemonitoring systems has made possible to collect symptoms and physiological data in electronic records, boosting the development of decision support systems (DSSs). Current DSSs work with physiological measurements collected by means of several measuring and communication devices as well as with symptoms gathered by questionnaires submitted to COPD subjects...
January 17, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28103561/statistical-shape-modeling-of-the-left-ventricle-myocardial-infarct-classification-challenge
#14
Avan Suinesiaputra, Pierre Ablin, Xenia Alba, Martino Alessandrini, Jack Allen, W Bai, Serkan Cimen, Peter Claes, Brett R Cowan, Jan D'hooge, Nicolas Duchateau, Jan Ehrhardt, Alejandro F Frangi, Ali Gooya, Vicente Grau, Karim Lekadir, Allen Lu, Anirban Mukhopadhyay, Ilkay Oksuz, Xavier Pennec, Marco Pereanez, Catarina Pinto, Paolo Piras, Marc-Michel Rohe, Daniel Rueckert, Maxime Sermesant, Kaleem Siddiqi, Mahdi Tabassian, Luciano Teresi, Sotirios A Tsaftaris, Matthias Wilms, Alistair A Young, Xingyu Zhang, Pau Medrano-Gracia
Statistical shape modeling is a powerful tool for visualizing and quantifying geometric and functional patterns of the heart. After myocardial infarction (MI), the left ventricle typically remodels in response to physiological challenges. Several methods have been proposed in the literature to describe statistical shape changes. Which method best characterizes left ventricular remodeling after MI is an open research question. A better descriptor of remodeling is expected to provide a more accurate evaluation of disease status in MI patients...
January 17, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28102833/a-multimodal-approach-to-estimating-vigilance-using-eeg-and-forehead-eog
#15
Wei-Long Zheng, Baoliang Lu
OBJECTIVE: Covert aspects of ongoing user mental states provide key context information for user-aware human computer interactions. In this paper, we focus on the problem of estimating the vigilance of users using EEG and EOG signals. APPROACH: The PERCLOS index as vigilance annotation is obtained from eye tracking glasses. To improve the feasibility and wearability of vigilance estimation devices for real-world applications, we adopt a novel electrode placement for forehead EOG and extract various eye movement features, which contain the principal information of traditional EOG...
January 19, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28100095/shoulder-kinetics-during-start-up-and-propulsion-with-a-manual-wheelchair-within-the-initial-phase-of-uninstructed-training
#16
Samuel Hybois, Alice Siegel, Joseph Bascou, Nicolas Eydieux, Philippe Vaslin, Hélène Pillet, Pascale Fodé, Christophe Sauret
PURPOSE: Wheelchair locomotion is constraining for the upper limbs and involves a set of motor tasks that need to be learnt by a novice user. To understand this integration process, we investigated the evolution of shoulder kinetics during start-up and propulsion within the initial phase of low-intensity uninstructed training. MATERIALS AND METHODS: Seventeen novice able-bodied subjects performed a 120-min uninstructed practice distributed over 4 weeks. During the initial and final sessions, upper limbs kinematics and hand-rim kinetics were continuously collected...
January 19, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28100066/identification-of-eggs-from-different-production-systems-based-on-hyperspectra-and-cs-svm
#17
J Sun, S Cong, H Mao, X Zhou, X Wu, X Zhang
1. To identify the origin of table eggs more accurately, a method based on hyperspectral imaging technology was studied. 2. The hyperspectral data of 200 samples of intensive and extensive eggs were collected. Standard normalised variables (SNV) combined with Savitzky-Golay (SG) were used to eliminate noise, then stepwise regression (SWR) was used for feature selection. Grid search algorithm (GS), genetic search algorithm (GA), particle swarm optimisation algorithm (PSO) and cuckoo search algorithm (CS) were applied by support vector machine (SVM) to establish a SVM identification model with the optimal parameters...
January 19, 2017: British Poultry Science
https://www.readbyqxmd.com/read/28100028/perirhinal-cortex-involvement-in-allocentric-spatial-learning-in-the-rat-evidence-from-doubly-marked-tasks
#18
Juan M J Ramos
It has recently been suggested that the different cortices of the medial temporal lobe support a mixture of object and spatial processing functions, challenging the anterior model that emphasized a strict functional differentiation between regions. However, for some structures, the perirhinal cortex (Prh) for example, a number of studies using lesion methods have shown a profound deficit exclusively in tasks involving object learning but not allocentric spatial learning. It may be that the learning paradigms used in previous studies have not been sensitive enough to detect a possible allocentric deficit in Prh-lesioned animals...
January 18, 2017: Hippocampus
https://www.readbyqxmd.com/read/28099178/clinical-performance-evaluations-of-third-year-medical-students-and-association-with-student-and-evaluator-gender
#19
Alison Riese, Leah Rappaport, Brian Alverson, Sangshin Park, Randal M Rockney
PURPOSE: Clinical performance evaluations are major components of medical school clerkship grades. But are they sufficiently objective? This study aimed to determine whether student and evaluator gender is associated with assessment of overall clinical performance. METHOD: This was a retrospective analysis of 4,272 core clerkship clinical performance evaluations by 829 evaluators of 155 third-year students, within the Alpert Medical School grading database for the 2013-2014 academic year...
January 17, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28098822/application-of-fault-tree-analysis-and-fuzzy-neural-networks-to-fault-diagnosis-in-the-internet-of-things-iot-for-aquaculture
#20
Yingyi Chen, Zhumi Zhen, Huihui Yu, Jing Xu
In the Internet of Things (IoT) equipment used for aquaculture is often deployed in outdoor ponds located in remote areas. Faults occur frequently in these tough environments and the staff generally lack professional knowledge and pay a low degree of attention in these areas. Once faults happen, expert personnel must carry out maintenance outdoors. Therefore, this study presents an intelligent method for fault diagnosis based on fault tree analysis and a fuzzy neural network. In the proposed method, first, the fault tree presents a logic structure of fault symptoms and faults...
January 14, 2017: Sensors
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