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TGF-beta AND high glucose

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https://www.readbyqxmd.com/read/28656052/effect-of-huayu-tongluo-herbs-on-reduction-of-proteinuria-via-inhibition-of-wnt-%C3%AE-catenin-signaling-pathway-in-diabetic-rats
#1
Lu Bai, Beibei Huo, Zhiqiang Chen, Qian Guo, Jing Xu, Jing Fang, Jianghua Zhang, Fenfang Zhang
The study investigated the expression of Wnt/β-catenin pathway in diabetic rats and the intervention effect of Huayu Tongluo herbs (HTH). Ten rats were randomly selected as control group and the remaining rats were established as diabetic models. The diabetic rats were randomly divided into model group and HTH treatment group. The intervention was intragastric administration in all rats for 20 weeks. At the end of every 4 weeks, fasting blood glucose and 24 h urinary total protein quantitatively were measured...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28588674/resveratrol-ameliorates-diabetic-nephropathy-in-rats-through-negative-regulation-of-the-p38-mapk-tgf-%C3%AE-1-pathway
#2
Yuan Qiao, Ke Gao, Yangwei Wang, Xueliang Wang, Bo Cui
Resveratrol (RSV) has been shown to have a renoprotective effect against diabetic nephropathy, but the underlying mechanisms of this have not been fully elucidated. The aim of the current study was to explore the mechanisms responsible for the therapeutic effects of RSV in rat mesangial cells in vitro and in a rat model of diabetic nephropathy. The viability of CRL-2573 rat mesangial cells and their expression levels of p38, phosphorylated (p)-p38, transforming growth factor beta 1 (TGF-β1) and fibronectin were assessed in response to treatment with high glucose, with or without RSV...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28424263/the-kielin-chordin-like-protein-kcp-attenuates-high-fat-diet-induced-obesity-and-metabolic-syndrome-in-mice
#3
Abdul Soofi, Katherine I Wolf, Margo P Emont, Nathan Qi, Gabriel Martinez-Santibanez, Edward Grimley, Wesam Ostwani, Gregory R Dressler
Obesity and its associated complications such as insulin resistance and non-alcoholic fatty liver disease are reaching epidemic proportions. In mice, the TGF-β superfamily is implicated in the regulation of white and brown adipose tissue differentiation. The kielin/chordin-like protein (KCP) is a secreted regulator of the TGF-β superfamily pathways that can inhibit both TGF-β and activin signals while enhancing bone morphogenetic protein (BMP) signaling. However, KCP's effects on metabolism and obesity have not been studied in animal models...
June 2, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28111218/betanin-isolated-from-fruits-of-opuntia-elatior-mill-attenuates-renal-fibrosis-in-diabetic-rats-through-regulating-oxidative-stress-and-tgf-%C3%AE-pathway
#4
COMPARATIVE STUDY
Brijesh Sutariya, Madhusudan Saraf
ETHNOPHARMACOLOGICAL RELEVANCE: The fruits of Opuntia elatior Mill are being used traditionally in different disease condition like diabetes, obesity, asthma, inflammatory disorders, and anemia. Betanin, a compound isolated from fruits of Opuntia elatior Mill has potent anti-oxidative and anti-inflammatory activity. Recent study from our lab indicated the protective effect of betanin against high glucose induced rat renal epithelial cell fibrosis and matrix accumulation, major features of diabetic nephropathy (DN)...
February 23, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27755557/an-abbreviated-protocol-for-in-vitro-generation-of-functional-human-embryonic-stem-cell-derived-beta-like-cells
#5
Mohammad Massumi, Farzaneh Pourasgari, Amarnadh Nalla, Battsetseg Batchuluun, Kristina Nagy, Eric Neely, Rida Gull, Andras Nagy, Michael B Wheeler
The ability to yield glucose-responsive pancreatic beta-cells from human pluripotent stem cells in vitro will facilitate the development of the cell replacement therapies for the treatment of Type 1 Diabetes. Here, through the sequential in vitro targeting of selected signaling pathways, we have developed an abbreviated five-stage protocol (25-30 days) to generate human Embryonic Stem Cell-Derived Beta-like Cells (ES-DBCs). We showed that Geltrex, as an extracellular matrix, could support the generation of ES-DBCs more efficiently than that of the previously described culture systems...
2016: PloS One
https://www.readbyqxmd.com/read/27620491/protective-role-of-activin-receptor-like-kinase-7-gene-silencing-in-renal-fibrosis
#6
Mei Zhao, Lei Zhang, Lin Liu, Ya Li, Di Wang, Yi-Hui Li, Zhi-Hao Wang, Wei Zhang, Yun Zhang, Ming Zhong, Meng-Xiong Tang
BACKGROUND: Renal fibrosis is a process of excess accumulation and deposition of extracellular matrix (ECM) proteins in kidney. Transforming growth factor-beta (TGF-β) plays a vital role in accumulation of ECM through initiating phosphorylated Smad2/3. Whether activin receptor-like kinase 7 (ALK7), a member of TGF-β superfamily, was involved in renal interstitial fibrosis remains unclear. The aim of this study was to investigate whether ALK7 participates in renal fibrosis via regulating phosphorylated Smad2/3 in high-fat diet (HFD) rats...
September 13, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27585521/persistent-insulin-resistance-in-podocytes-caused-by-epigenetic-changes-of-shp-1-in-diabetes
#7
Farah Lizotte, Benoit Denhez, Andréanne Guay, Nicolas Gévry, Anne Marie Côté, Pedro Geraldes
Poor glycemic control profoundly affects protein expression and the cell signaling action that contributes to glycemic memory and irreversible progression of diabetic nephropathy (DN). We demonstrate that SHP-1 is elevated in podocytes of diabetic mice, causing insulin unresponsiveness and DN. Thus, sustained SHP-1 expression caused by hyperglycemia despite systemic glucose normalization could contribute to the glycemic memory effect in DN. Microalbuminuria, glomerular filtration rate, mesangial cell expansion, and collagen type IV and transforming growth factor-β expression were significantly increased in diabetic Ins2(+/C96Y) mice compared with nondiabetic Ins2(+/+) mice and remained elevated despite glucose normalization with insulin implants...
December 2016: Diabetes
https://www.readbyqxmd.com/read/27317945/tgr5-activation-suppressed-s1p-s1p2-signaling-and-resisted-high-glucose-induced-fibrosis-in-glomerular-mesangial-cells
#8
Zhiying Yang, Fengxiao Xiong, Yu Wang, Wenyan Gong, Junying Huang, Cheng Chen, Peiqing Liu, Heqing Huang
Glucose and lipid metabolism disorders and chronic inflammation in the kidney tissues are largely responsible for causative pathological mechanism of renal fibrosis in diabetic nephropathy (DN). As our previous findings confirmed that, sphingosine 1-phosphate (S1P)/sphingosine 1-phosphate receptor 2 (S1P2) signaling activation promoted renal fibrosis in diabetes. Numerous studies have demonstrated that the G protein-coupled bile acid receptor TGR5 exhibits effective regulation of glucose and lipid metabolism and anti-inflammatory effects...
September 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27112839/synergistic-effects-of-c-jun-and-sp1-in-the-promotion-of-tgf%C3%AE-1-mediated-diabetic-nephropathy-progression
#9
Pan Gao, Yingze Wei, Zhigang Zhang, Wenjiao Zeng, Daming Sun, Danyang Liu, Bo Hou, Congying Zhang, Nong Zhang, Hui Li, Liliang Li
Diabetic nephropathy (DN) is a major complication of diabetes mellitus. Transforming growth factor beta 1 (TGFβ1) is a well-distinguished mediator of progressive renal fibrosis in DN. However, the molecular mechanisms contributing to enhanced TGFβ1 expression in the progression of DN are not fully understood. Herein, we reported that c-Jun and specificity protein 1 (SP1) were critical upstream regulators of TGFβ1 expression in DN. The increase in c-Jun and SP1 expressions was positively correlated with TGFβ1 in both high glucose-treated human renal mesangial cells (HRMCs) and diabetic kidneys...
June 2016: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/27105914/high-glucose-induced-matrilin-2-expression-in-mouse-mesangial-cells-was-mediated-by-transforming-growth-factor-beta-1-tgf-%C3%AE-1
#10
Shukun Zhang, Menglan Zhang, Hong Huang, Shiying Zhou, Yanshneg Du, Xin Yi, Junming Luo
This study aimed at evaluating the effect of high glucose on the expression of extracellular matrix (ECM) protein Matrilin-2 and the mechanism underlying this effect by using a mouse mesangial cell line. Mouse mesangial cells (MMCs) were cultured in media containing normal (5 mM d-glucose) or high concentrations of glucose (30 mM d-glucose). The expression of Matrilin-2 was assessed by either RT-PCR or western blot. Additionally, transforming growth factor beta 1 (TGF-β1) inhibitors and TGF-β1 were used to determine whether glucose-regulated Matrilin-2 expression was mediated by the TGF-β1/Smad3 signaling pathway...
May 27, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/26526881/a-new-agkistrodon-halys-venom-purified-protein-c-activator-prevents-myocardial-fibrosis-in-diabetic-rats
#11
Shu Li, Yun Hong, Xin Jin, Genbao Zhang, Zaichang Hu, Liuwang Nie
AIM: To assess the effects of protein C activator (PCA) from Agkistrodon halys snake venom on cardiac fibrosis in streptozotocin (STZ) induced diabetic rat model, and investigate the mechanisms of its action. METHODS: PCA was identified by one-dimensional reversed phase liquid chromatography - mass spectrometry/mass spectrometry. Male Sprague-Dawley rats (120-140 g) were randomly assigned to negative control (NC) and diabetic group. Diabetes was induced by STZ in high-fat diet fed rats...
October 2015: Croatian Medical Journal
https://www.readbyqxmd.com/read/26362188/branched-chain-amino-acids-attenuate-early-kidney-injury-in-diabetic-rats
#12
Na Mi, Xiu Juan Zhang, Yan Ding, Guo Hua Li, Wei Dong Wang, Hui Xia Xian, Jin Xu
Diabetic nephropathy (DN) is the most severe diabetic microvascular complication. The pathogenesis of diabetic nephropathy is complex, and oxidative stress plays an important role in the development of diabetic nephropathy. Elevated reactive oxygen species (ROS) levels activate various signaling pathways and influence the activities of transforming growth factor-β (TGF-β) and matrix metalloproteinase-9 (MMP-9), which contributes to glomerular hypertrophy. Branched-chain amino acids (BCAAs) are widely used in clinical treatment, and BCAAs can reduce the oxidative stress associated with the diabetic pancreas and some liver diseases...
October 16, 2015: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/26341651/gallic-acid-ameliorates-renal-functions-by-inhibiting-the-activation-of-p38-mapk-in-experimentally-induced-type-2-diabetic-rats-and-cultured-rat-proximal-tubular-epithelial-cells
#13
Amjid Ahad, Haseeb Ahsan, Mohd Mujeeb, Waseem Ahmad Siddiqui
Diabetic nephropathy (DN) is one of the leading causes of morbidity and mortality in diabetic patients that accounts for about 40% of deaths in type 2 diabetes. p38 mitogen activated protein kinase (p38 MAPK), a serine-threonine kinase, plays an important role in tissue inflammation and is known to be activated under conditions of oxidative stress and hyperglycemia. The role of p38 MAPK has been demonstrated in DN, and its inhibition has been suggested as an alternative approach in the treatment of DN. In the present study, we investigated the nephroprotective effects of an anti-inflammatory phenolic compound, gallic acid (GA, 3,4,5-trihydroxybenzoic acid), in high fat diet/streptozotocin (HFD/STZ) induce type 2 diabetic wistar albino rats...
October 5, 2015: Chemico-biological Interactions
https://www.readbyqxmd.com/read/26221223/reduced-beta-2-glycoprotein-i-improve-diabetic-nephropathy-via-inhibiting-tgf-%C3%AE-1-p38-mapk-pathway
#14
Tong Wang, Si-Si Chen, Rui Chen, De-Min Yu, Pei Yu
PURPOSE: Beta 2 glycoprotein I (β2GPI) has been shown the positive effect on diabetic atherosclerosis and retinal neovascularization. β2GPI can be reduced by thioredoxin-1, resulting in the reduced state of β2GPI. The possible protective effects of β2GPI and reduced β2GPI on diabetic nephropathy (DN) are not fully elucidated. The purpose of this study was to test a hypothesis that β2GPI and reduced β2GPI would improve DN in streptozotocin (STZ) induced diabetic mice and high-glucose (HG) exposed rat mesangial cell (RMC)...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26045739/reduced-beta-2-glycoprotein-i-improves-diabetic-nephropathy-via-inhibiting-tgf-%C3%AE-1-p38-mapk-pathway
#15
Tong Wang, Si-Si Chen, Rui Chen, De-Min Yu, Pei Yu
PURPOSE: Beta 2 glycoprotein I (β2GPI) has been shown the positive effect on diabetic atherosclerosis and retinal neovascularization. β2GPI can be reduced by thioredoxin-1, resulting in the reduced state of β2GPI. The possible protective effects of β2GPI and reduced β2GPI on diabetic nephropathy (DN) are not fully elucidated. The purpose of this study was to test a hypothesis that β2GPI and reduced β2GPI would improve DN in streptozotocin (STZ) induced diabetic mice and high-glucose (HG) exposed rat mesangial cell (RMC)...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/25882007/beta-casomorphin-7-prevents-epithelial-mesenchymal-transdifferentiation-of-nrk-52e-cells-at-high-glucose-level-involvement-of-angii-tgf-%C3%AE-1-pathway
#16
Wei Zhang, Shangxin Song, Fei Liu, Yi Liu, Yuanshu Zhang
BACKGROUND: Hyperglycemia is the most important risk factor in the progression of renal fibrosis in diabetic kidney. Based on previous studies, β-casomorphin-7 may exert anti-fibrotic activities in diabetic rats. However, the role of β-casomorphin-7 in the pathogenesis of renal tubulointerstitial fibrosis remains unclear. Thus, this study was designed to investigate the protective effect of β-casomorphin-7 on epithelial-mesenchymal transition (EMT) of NRK-52E cells treated under hyperglycemic condition and to explore the possible mechanism...
August 2015: Peptides
https://www.readbyqxmd.com/read/25880429/oryeongsan-suppressed-high-glucose-induced-mesangial-fibrosis
#17
Jung Joo Yoon, Yun Jung Lee, So Min Lee, Dae Gill Kang, Ho Sub Lee
BACKGROUND: The pathological change of kidney in diabetic nephropathy is represented hypertrophy, inflammation, and renal fibrosis. Oryeongsan, traditional oriental herbal formula, is widely used for the treatment of nephrosis, dropsy, and uremia. This study was examined whether Oryeongsan attenuate high-glucose (HG)-promoted rat mesangial cell fibrosis and matrix accumulation, major features of diabetic glomerulosclerosis. METHODS: Oryeongsan was mixed traditional herbal medicine, Alisma orientale Juz, Polyporus umbellatus Fries, Atractylodes macrocephala Koidez, Poria cocos Wolf and Cinnamomum Cassia Presl (5:3:3:1)...
2015: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/25833251/effects-of-activin-a-on-survival-function-and-gene-expression-of-pancreatic-islets-from-non-diabetic-and-diabetic-human-donors
#18
Melissa L Brown, Nathan Ungerleider, Lara Bonomi, Danielle Andrzejewski, Amy Burnside, Alan Schneyer
Emerging evidence suggests that activin with its associated receptors, second messengers, and antagonists would be excellent targets for therapeutic drug development in the treatment of diabetes. We undertook the current study to investigate the ability to extrapolate findings from rodent studies to human islets in which data thus far has been scarce. We tested the hypothesis that human islets synthesize activin and that activin participates in the regulation of islet β-cells. Human islets from 33 separate isolations were categorized based on functional status, culture status and diabetic status...
2014: Islets
https://www.readbyqxmd.com/read/25753689/sirt1-reduction-causes-renal-and-retinal-injury-in-diabetes-through-endothelin-1-and-transforming-growth-factor-%C3%AE-1
#19
Rokhsana Mortuza, Biao Feng, Subrata Chakrabarti
In diabetes, hyperglycaemia causes up-regulation of endothelin 1 (ET-1) and transforming growth factor beta 1 (TGF-β1). Previously we showed glucose reduces sirtuin1 (SIRT1), a class III histone deacetylase. Here, we investigated the regulatory role of SIRT1 on ET-1 and TGF-β1 expression. Human microvascular endothelial cells were examined following incubation with 25 mmol/l glucose (HG) and 5 mmol/l glucose (NG) with or without SIRT1 or histone acetylase p300 overexpression or knockdown. mRNA expressions of ET-1, TGF-β1, SIRT1, p300 and collagen 1α(I) were examined...
August 2015: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/25715833/prolactin-anterior-pituitary-expression-and-circulating-levels-are-reduced-in-obese-and-diabetic-rats-role-of-tgf-%C3%AE-and-tnf-%C3%AE
#20
María Lemini, Xarubet Ruiz-Herrera, María G Ledesma-Colunga, Nundehui Díaz-Lezama, Ericka A De Los Ríos, Fernando López-Barrera, Isabel Méndez, Gonzalo Martínez de la Escalera, Yazmín Macotela, Carmen Clapp
The levels of the hormone prolactin (PRL) are reduced in the circulation of patients with Type 2 diabetes and in obese children, and lower systemic PRL levels correlate with an increased prevalence of diabetes and a higher risk of metabolic syndrome. The secretion of anterior pituitary (AP) PRL in metabolic diseases may be influenced by the interplay between transforming growth factor β (TGF-β) and tumor necrosis factor α (TNF-α), which inhibit and can stimulate AP PRL synthesis, respectively, and are known contributors to insulin resistance and metabolic complications...
May 1, 2015: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
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