keyword
MENU ▼
Read by QxMD icon Read
search

CTD

keyword
https://www.readbyqxmd.com/read/29625106/full-length-rpb1-is-required-in-two-step-shoot-regeneration
#1
Ying Li, Die Hu, Yi Li, Bo Yang, Qian Yu, Lei Ge
Regeneration is a complicated progress in plants and animals. Most multicellular organisms can regenerate new tissue when wounded, and plants excel most animals in their ability to regenerate whole new growth module from adult tissues. Regeneration in Arabidopsis includes two steps. Firstly, the explants from differentiated plant tissues such as roots or hypocotyls are induced to generate callus, then the shoots regenerate upon the callus. The phytohormone auxin and cytokinin play important parts in this process...
April 3, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29618128/anti-dfs70-autoantibodies-in-undifferentiated-connective-tissue-diseases-subjects-what-s-on-the-horizon
#2
Maria Infantino, Ora Shovman, Dolores Pérez, Mariangela Manfredi, Valentina Grossi, Maurizio Benucci, Francesca Li Gobbi, Francesca Bandinelli, Arianna Damiani, Paolo Moscato, Danielle Azoulay, Boris Gilburd, Yehuda Shoenfeld
Objective: The main objective was to determine the prevalence of anti-dense fine speckled (DFS70) antibodies in a stable population of undifferentiated connective tissue disease (UCTD) to better define their potential role. Methods: Immunological and clinical records of 91 long-standing UCTD patients were studied. DFS pattern was determined using the IIF ANA test on HEp-2 cells and anti-DFS70 antibodies were tested by chemiluminescence assay and by DFS70 line immunoassay...
April 3, 2018: Rheumatology
https://www.readbyqxmd.com/read/29608126/gender-differences-in-the-prevalence-of-fibromyalgia-and-in-concomitant-medical-and-psychiatric-disorders-a-national-veterans-health-administration-study
#3
Caroline A Arout, Mehmet Sofuoglu, Lori A Bastian, Robert A Rosenheck
BACKGROUND: Fibromyalgia is a poorly understood, chronically disabling pain syndrome. While research has focused on its clinical presentation and treatment, less is known about fibromyalgia's clinical epidemiology in real-world healthcare systems. Gender differences have been difficult to study because relatively few males are diagnosed with fibromyalgia. METHODS: Veterans Health Administration (VHA) patients diagnosed with fibromyalgia nationwide in FY 2012 were compared to Veterans with other pain diagnoses on sociodemographic characteristics, medical and psychiatric diagnoses, health service use, and opioid and psychotropic prescription fills...
April 2, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29607151/lung-cancer-in-connective-tissue-disease-associated-interstitial-lung-disease-clinical-features-and-impact-on-outcomes
#4
Satoshi Watanabe, Keigo Saeki, Yuko Waseda, Akari Murata, Hazuki Takato, Yukari Ichikawa, Masahide Yasui, Hideharu Kimura, Yasuhito Hamaguchi, Takashi Matsushita, Kazunori Yamada, Mitsuhiro Kawano, Kengo Furuichi, Takashi Wada, Kazuo Kasahara
Backgrounds: Lung cancer (LC) adversely impacts survival in patients with idiopathic pulmonary fibrosis. However, little is known about LC in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD). The aim of this study was to evaluate the prevalence of and risk factors for LC in CTD-ILD, and the clinical characteristics and survival of CTD-ILD patients with LC. Methods: We conducted a single-center, retrospective review of patients with CTD-ILD from 2003 to 2016...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29606859/-ppargamma-2-and-adrb3-polymorphisms-in-connective-tissue-diseases-and-lipid-disorders
#5
Bogna Grygiel-Górniak, Iwona Ziółkowska-Suchanek, Elżbieta Kaczmarek, Maria Mosor, Jerzy Nowak, Mariusz Puszczewicz
Background: The aim of the research genetic study was to investigate the association between variants (C1431T and Pro12Ala) of the peroxisome proliferator-activated receptor ( PPARgamma-2 ) gene, Trp64Arg polymorphism of the beta-3-adrenergic receptor gene and lipid profile in Polish population including group of 103 patients with connective tissue disease (CTD) and 103 sex-and age-matched controls in context of statin use. Methods: Anthropometric and biochemical parameters were measured by routine methods, followed by genotyping (TagMan® Genotyping Assays, PCR-restriction fragment length polymorphism analysis)...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29603493/lncrna-ctd-2108o9-1-represses-breast-cancer-metastasis-by-influencing-lifr
#6
Mozhi Wang, Mengshen Wang, Zhenning Wang, Xueting Yu, Yongxi Song, Chong Wang, Yujie Xu, Fengheng Wei, Yi Zhao, Yingying Xu
Breast cancer (BC) is an aggressive malignant disease in women worldwide with high tendency to metastasize. However, impactful biomarkers for BC metastasis remain largely undefined. In this study, we identified that lncRNA-CTD-2108O9.1 is downregulated in BC tissues and cells and acts as a metastatic inhibitor on BC. Mechanistic investigation determined that lncRNA-CTD-2108O9.1 repress metastasis by targeting LIFR, which is designated as a metastasis suppressor in BC. Our study characterizes a significant tumor suppressor active in BC metastasis repression via the known metastasis inhibitor LIFR...
March 30, 2018: Cancer Science
https://www.readbyqxmd.com/read/29596085/the-influence-of-connective-tissue-disease-in-breast-reconstruction-a-national-database-analysis
#7
Austin D Chen, David Chi, Winona W Wu, Sabine A Egeler, Anmol S Chattha, Alexandra Bucknor, Bernard T Lee, Samuel J Lin
BACKGROUND: Patients with connective tissue diseases (CTD), or collagen vascular diseases, are at risk of potentially higher morbidity after surgical procedures. We aimed to investigate the complication profile in CTD versus non-CTD patients who underwent breast reconstruction on a national scale. METHODS: A retrospective analysis of the Healthcare Cost and Utilization Project NIS Database between 2010 and 2014 was conducted for patients 18 years or older admitted for immediate autologous or implant breast reconstruction...
March 29, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29575410/performance-of-the-st-george-s-respiratory-questionnaire-in-patients-with-connective-tissue-disease-associated-interstitial-lung-disease
#8
Atsushi Suzuki, Yasuhiro Kondoh, Jeffrey J Swigris, Masahiko Ando, Tomoki Kimura, Kensuke Kataoka, Yasuhiko Yamano, Taiki Furukawa, Mari Numata, Koji Sakamoto, Yoshinori Hasegawa
BACKGROUND AND OBJECTIVE: The St George's Respiratory Questionnaire (SGRQ) is a self-administered questionnaire used to assess health-related quality of life (HRQoL) in various chronic respiratory diseases. Few studies have assessed the performance of the SGRQ in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD). We aimed to examine the SGRQ's performance characteristics and generate data to support its reliability and validity in patients with CTD-ILD...
March 25, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29573374/silencing-arabidopsis-carboxyl-terminal-domain-phosphatase-like-4-induces-cytokinin-oversensitive-de-novo-shoot-organogenesis
#9
Akihito Fukudome, Jared S Goldman, Scott A Finlayson, Hisashi Koiwa
De novo shoot organogenesis (DNSO) is a post-embryonic development program that has been widely exploited by plant biotechnology. DNSO is a hormonally regulated process, where auxin and cytokinin (CK) coordinate suites of genes encoding transcription factors, general transcription factors, and RNA metabolism machinery genes. Here we report that silencing Arabidopsis thaliana carboxyl-terminal domain (CTD) phosphatase-like 4 (CPL4RNA i ), which increases phosphorylation level of RNA polymerase II (pol II) CTD, altered lateral root development and DNSO efficiency of the host plants...
March 24, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29568772/a-two-step-feature-selection-method-to-predict-cancerlectins-by-multiview-features-and-synthetic-minority-oversampling-technique
#10
Runtao Yang, Chengjin Zhang, Lina Zhang, Rui Gao
Cancerlectins have an inhibitory effect on the growth of cancer cells and are currently being employed as therapeutic agents. The accurate identification of the cancerlectins should provide insight into the molecular mechanisms of cancers. In this study, a new computational method based on the RF (Random Forest) algorithm is proposed for further improving the performance of identifying cancerlectins. Hybrid feature space before feature selection is developed by combining different individual feature spaces, CTD (Composition, Transition, and Distribution), PseAAC (Pseudo Amino Acid Composition), PSSM (Position-Specific Scoring Matrix), and disorder...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29558039/analysis-of-peripheral-nerve-and-autonomic-nervous-system-function-and-the-stage-of-microangiopathy-in-patients-with-secondary-raynaud-s-phenomenon-in-the-course-of-connective-tissue-diseases
#11
Izabela Gosk-Bierska, Maria Misterska-Skóra, Marta Wasilewska, Małgorzata Bilińska, Jerzy Gosk, Rajmund Adamiec, Magdalena Koszewicz
BACKGROUND: The pathogenesis of secondary Raynaud's phenomenon (SRP) associated with connective tissue diseases (CTD) is not entirely understood. Nervous system dysfunction and microangiopathy are considered to be causes of this pathology. OBJECTIVES: Peripheral and autonomic nervous system function, the stage of microangiopathy, and the relationships between these in patients with SRP were analyzed. MATERIAL AND METHODS: In the study, 20 patients with CTD-related SRP and 30 healthy controls were subject to capillaroscopy, standard conduction velocity tests and conduction velocity distribution (CVD) tests in ulnar and peroneal nerves, heart rate variability (HRV), and sympathetic skin response (SSR) tests...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29555476/tdp-43-ntd-can-be-induced-while-ctd-is-significantly-enhanced-by-ssdna-to-undergo-liquid-liquid-phase-separation
#12
Lu Wang, Jian Kang, Liangzhong Lim, Yuanyuan Wei, Jianxing Song
TDP-43 inclusions are characterized by a large spectrum of neurodegenerative diseases such as ALS and Alzheimer's. Functionally, TDP-43 is engaged in forming dynamic granules via liquid-liquid phase separation (LLPS), which is now recognized to be a general principle for organizing a variety of cellular membrane-less organelles. TDP-43 is composed of the N-terminal domain (NTD) adopting an ubiquitin-like fold, two RRMs and C-terminal domain (CTD) with the low-complexity (LC) prion-like sequences. Previously, only the CTD was found to undergo LLPS to form dynamic liquid droplets with relatively small numbers and sizes...
March 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29549877/reduced-specificity-of-autobiographical-memories-in-young-people-with-tic-disorders
#13
Victoria Pile, Sally Robinson, Elystan Roberts, Marta Topor, Tammy Hedderly, Jennifer Y F Lau
OBJECTIVE: Depression is common in Tourette syndrome and Chronic Tic Disorders (TS/CTD) and contributes to significant impairment. The specificity of autobiographical memories is implicated in an individual's sense of self and their daily functioning but also in the onset and development of depression in the general population. Here, we examined whether memory specificity is reduced in young people with TS/CTD, relative to control participants, and whether memory specificity is associated with depression...
March 6, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29545334/icec0942-an-orally-bioavailable-selective-inhibitor-of-cdk7-for-cancer-treatment
#14
Hetal Patel, Manikandan Periyasamy, Georgina P Sava, Alexander Bondke, Brian W Slafer, Sebastian H B Kroll, Marion Barbazanges, Richard Starkey, Silvia Ottaviani, Alison Harrod, Eric O Aboagye, Laki Buluwela, Matthew J Fuchter, Anthony G M Barrett, Charles Coombes, Simak Ali
Recent reports indicate that some cancer types are especially sensitive to transcription inhibition, suggesting that targeting the transcriptional machinery provides new approaches to cancer treatment. Cyclin-dependent kinase (CDK)7 is necessary for transcription, and acts by phosphorylating the C-terminal domain (CTD) of RNA polymerase II (PolII) to enable transcription initiation. CDK7 additionally regulates the activities of a number of transcription factors, including Estrogen receptor-α (ER). Here we describe a new, orally bioavailable CDK7 inhibitor, ICEC0942...
March 15, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29544209/the-use-of-infrared-thermal-imaging-as-a-non-destructive-screening-tool-for-identifying-drought-tolerant-lentil-genotypes
#15
Sajitha Biju, Sigfredo Fuentes, Dorin Gupta
Lentil (Lens culinaris, Medik.) is an important legume crop, which often experience drought stress especially at the flowering and grain filling phenological stages. The availability of efficient and robust screening tools based on relevant non-destructive quantifiable traits would facilitate research on crop improvement for drought tolerance. The objective of this study was to evaluate the drought tolerance of 37 lentil genotypes using infrared thermal imaging (IRTI), drought tolerance parameters and multivariate data analysis...
March 8, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29538197/prevalence-of-lung-cancer-in-patients-with-interstitial-lung-disease-is-higher-than-in-those-with-chronic-obstructive-pulmonary-disease
#16
Hye In Jung, Jae Seok Park, Mi-Young Lee, ByeongJu Park, Hyun Jung Kim, Sun Hyo Park, Won-Il Choi, Choong Won Lee
We aimed to explore lung cancer prevalence in interstitial lung disease (ILD) patients with or without connective tissue disorder (CTD) and idiopathic pulmonary fibrosis (IPF) in comparison with chronic obstructive pulmonary disorder (COPD).We evaluated lung cancer prevalence associated with ILD and IPF using Korean Health Insurance Review and Assessment Service (HIRA) data from January to December 2011. This database (HIRA-NPS-2011-0001) was sampled using random sampling of outpatients; 1,375,842 sample cases were collected, and 670,258 (age ≥ 40 ys) were evaluated...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29532744/associations-between-maternal-clinical-features-and-fetal-outcomes-in-pregnancies-of-mothers-with-connective-tissue-diseases
#17
Ayako Ohyama, Hiroto Tsuboi, Hisashi Noma, Mayu Terasaki, Masaru Shimizu, Hirofumi Toko, Fumika Honda, Mizuki Yagishita, Hiroyuki Takahashi, Hiromitsu Asashima, Shinya Hagiwara, Yuya Kondo, Isao Matsumoto, Takayuki Sumida
OBJECTIVES: The purpose of this study is to clarify associations between maternal clinical features and adverse pregnancy outcomes (APOs) in mothers with connective tissue diseases (CTDs). METHODS: We retrospectively examined maternal clinical features including backgrounds, autoantibodies, CTD flare-ups, and therapies during pregnancies as well as fetal outcomes in 90 pregnancies (66 mothers) at our hospital from January 2006 to September 2016. RESULTS: Underlying CTDs were SLE (N = 41), MCTD (N = 10), RA (N = 15), SS (N = 10), and others (N = 14)...
March 13, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29526634/solid-phase-assays-versus-automated-indirect-immunofluorescence-for-detection-of-antinuclear-antibodies
#18
REVIEW
Jolien Claessens, Thibaut Belmondo, Ellen De Langhe, Rene Westhovens, Koen Poesen, Sophie Hüe, Daniel Blockmans, Michael Mahler, Marvin J Fritzler, Xavier Bossuyt
Solid phase assays (SPAs) and automated microscope systems are increasingly used to screen for antinuclear antibodies (ANAs). The goal of this study was to evaluate the performance of three automated ANA screening assays; NOVA Lite HEp-2 using NOVA View® (NV, Inova Diagnostics), an automated indirect immunofluorescence method, EliA™ CTD Screen (Fluorescence Enzyme Immunoassay, FEIA; Thermo Fisher) and QUANTA Flash® CTD Screen Plus (Chemiluminescence immunoassay, CIA; Inova Diagnostics). The assays were performed on 480 diagnostic samples from patients with an ANA-associated rheumatic disease (AARD; systemic lupus erythematosus, primary Sjögren's syndrome, systemic sclerosis, inflammatory myopathy, mixed connective tissue disease) and on 767 samples from diseased and healthy controls...
March 8, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29525275/a-15-long-non-coding-rna-signature-to-improve-prognosis-prediction-of-cervical-squamous-cell-carcinoma
#19
Xiaogang Mao, Xiaomin Qin, Lin Li, Jinting Zhou, Min Zhou, Xianxian Li, Ying Xu, Liyun Yuan, Qiong-Na Liu, Hui Xing
Long non-coding RNAs (lncRNAs), which have little or no protein-coding capacity, caught a particular interest since their potential roles in the cancer paradigm. As the most common cancer in women, cervical squamous cell carcinoma remains one of the leading causes of deaths from cancer. However, limited evidence is available to determine the role of lncRNAs in the prognosis of cervical squamous cell carcinoma. In this study, we collected lncRNA expression profiling to identify prognosis related lncRNAs for cervical squamous cell carcinoma from TCGA database...
March 7, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29523636/repeat-specific-functions-for-the-c-terminal-domain-of-rna-polymerase-ii-in-budding-yeast
#20
Michael Babokhov, Mohammad M Mosaheb, Richard W Baker, Stephen M Fuchs
The C-terminal domain (CTD) of the largest subunit of RNA polymerase II (RNAPII) is required to regulate transcription and to integrate it with other essential cellular processes. In the budding yeast Saccharomyces cerevisiae , the CTD of Rpb1p consists of 26 conserved heptad repeats that are post-translationally modified to orchestrate protein factor binding at different stages of the transcription cycle. A long-standing question in the study of the CTD is if there are any functional differences between the 26 repeats...
March 9, 2018: G3: Genes—Genomes—Genetics
keyword
keyword
93678
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"