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Geriatric prognosis

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https://www.readbyqxmd.com/read/28708810/role-of-normalized-t-cell-subsets-in-predicting-comorbidities-in-a-large-cohort-of-geriatric-hiv-infected-patient
#1
A Calcagno, S Piconi, E Focà, S Nozza, F Carli, C Montrucchio, A M Cattelan, G Orofino, B M Celesia, V Morena, G V De Socio, G Guaraldi
BACKGROUND: Adults aging with HIV are at greater risk for several comorbidities. The CD4+ cell count and CD4+/CD8+ ratio often fail to normalize in elderly patients despite prolonged antiretroviral therapy; this has been associated with concomitant diseases and poor prognosis. METHODS: A cross-sectional analysis in antiretroviral-treated HIV-positive patients aged ≥65 years. Aim of the study was to describe the predictors of normalized T cell subsets ("nT", CD4+/CD8+ ratio ≥1 and CD4+ ≥500 cells/uL) in a cohort of geriatric HIV-positive patients and its association with HIV-associated non-AIDS conditions (HANA)...
July 8, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28660188/microrna-in-cardiovascular-aging-and-age-related-cardiovascular-diseases
#2
REVIEW
Claudio de Lucia, Klara Komici, Giulia Borghetti, Grazia Daniela Femminella, Leonardo Bencivenga, Alessandro Cannavo, Graziamaria Corbi, Nicola Ferrara, Steven R Houser, Walter J Koch, Giuseppe Rengo
Over the last decades, life expectancy has significantly increased although several chronic diseases persist in the population, with aging as the leading risk factor. Despite improvements in diagnosis and treatment, many elderlies suffer from cardiovascular problems that are much more frequent in an older, more fragile organism. In the long term, age-related cardiovascular diseases (CVDs) contribute to the decline of quality of life and ability to perform normal activities of daily living. microRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the posttranscriptional level in both physiological and pathological conditions...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28635539/an-old-challenge-with-new-promises-a-systematic-review-on-comprehensive-geriatric-assessment-in-long-term-care-facilities
#3
Francesco Panza, Vincenzo Solfrizzi, Madia Lozupone, Maria Rosaria Barulli, Francesca D'Urso, Roberta Stallone, Vittorio Dibello, Alessia Noia, Cristina Di Dio, Antonio Daniele, Antonello Bellomo, Davide Seripa, Antonio Greco, Giancarlo Logroscino
Comprehensive geriatric assessment (CGA) is a multidimensional and multidisciplinary diagnostic process focused on determining the clinical profile, pathological risk, residual skills, short- and long-term prognosis, and the personalized therapeutic and care plan of the functionally compromised and frail older subjects. Previous evidence suggested that the effectiveness of CGA programs may be influenced by the settings where the CGA is performed [i.e., hospital, post-hospital discharge/ long-term care facilities (LTCF), or community/home] as well as the specific clinical conditions of older frail individuals...
June 21, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28634893/geriatric-assessment-and-functional-decline-in-older-patients-with-lung-cancer
#4
L Decoster, C Kenis, D Schallier, J Vansteenkiste, K Nackaerts, L Vanacker, N Vandewalle, J Flamaing, J P Lobelle, K Milisen, J De Grève, H Wildiers
PURPOSE: Older patients with lung cancer are a heterogeneous population making treatment decisions complex. This study aims to evaluate the value of geriatric assessment (GA) as well as the evolution of functional status (FS) in older patients with lung cancer, and to identify predictors associated with functional decline and overall survival (OS). METHODS: At baseline, GA was performed in patients ≥70 years with newly diagnosed lung cancer. FS measured by activities of daily living (ADL) and instrumental activities of daily living (IADL) was reassessed at follow-up to define functional decline and OS was collected...
June 20, 2017: Lung
https://www.readbyqxmd.com/read/28615514/prognostic-value-of-the-c-reactive-protein-prognostic-nutritional-index-ratio-after-hip-fracture-surgery-in-the-elderly-population
#5
Hanru Ren, Lianghao Wu, Wankun Hu, Xiuzhang Ye, Baoqing Yu
BACKGROUND: More and more older patients receive the surgery after hip fracture. However, the mortality rate is high. Prognostic nutritional index (PNI) is associated with prognosis in hip fracture patients. In the current study, we proposed a novel prognostic score, named c-reactive protein/PNI ratio (CRP/PNI ratio), for predicting the prognosis for geriatric orthopedic population. METHODS: This is a prospective study. Eighty cases of hip fracture surgery in the elderly population were studied to reveal the relationship between the CRP/PNI ratio and the clinicopathological characteristics of the elderly patients...
May 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28602363/epidemiology-pathophysiology-and-prognosis-of-heart-failure-in-older-adults
#6
REVIEW
Kumar Dharmarajan, Michael W Rich
Heart failure is the quintessential cardiovascular syndrome of aging that results from common cardiovascular conditions in older adults in conjunction with age-associated changes in cardiovascular structure and function. To a large extent, heart failure is a geriatric syndrome in much the same way that dementia, falls, and frailty are geriatric syndromes. The incidence and prevalence of heart failure increase strikingly with age and make heart failure the most common reason for hospitalization among older adults...
July 2017: Heart Failure Clinics
https://www.readbyqxmd.com/read/28584740/impact-of-preoperative-echocardiography-on-perioperative-management-in-geriatric-hip-trauma-a-retrospective-observational-study
#7
Chhavi Sawhney, Vivek Trikha, Sai Janani, Sukhminder Jit Singh Bajwa, Vijay Sharma, Menaal Khanna
BACKGROUND AND AIM: Hip fractures are associated with a significant risk of morbidity and mortality in the elderly population. Current guidelines propose that these patients should be operated as early as possible. Preoperative cardiac investigations, especially echocardiography, have been considered to delay surgery with few changes in the patient management. The present study has been conducted to evaluate whether preoperative echocardiography improve or worsen the prognosis in such hip trauma surgery...
April 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/28544188/novel-tool-for-deprescribing-in-chronic-patients-with-multimorbidity-list-of-evidence-based-deprescribing-for-chronic-patients-criteria
#8
Aitana Rodríguez-Pérez, Eva Rocío Alfaro-Lara, Sandra Albiñana-Perez, María Dolores Nieto-Martín, Jesús Díez-Manglano, Concepción Pérez-Guerrero, Bernardo Santos-Ramos
AIM: To create a tool to identify drugs and clinical situations that offers an opportunity of deprescribing in patients with multimorbidity. METHODS: A literature review completed with electronic brainstorming, and subsequently, a panel of experts using the Delphi methodology were applied. The experts assessed the criteria identified in the literature and brainstorming as possible situations for deprescribing. They were also asked to assess the influence of life prognosis in each criterion...
May 21, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28529911/severe-trauma-in-the-geriatric-population
#9
REVIEW
Juan Antonio Llompart-Pou, Jon Pérez-Bárcena, Mario Chico-Fernández, Marcelino Sánchez-Casado, Joan Maria Raurich
Geriatric trauma constitutes an increasingly recognized problem. Aging results in a progressive decline in cellular function which leads to a loose of their capacity to respond to injury. Some medications commonly used in this population can mask or blunt the response to injury. Falls constitute the most common cause of trauma and the leading cause of trauma-related deaths in this population. Falls are complicated by the widespread use of antiplatelets and anticoagulants, especially in patients with brain injury...
May 4, 2017: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28511639/physical-activity-among-hospitalized-older-adults-an-observational-study
#10
Sigurd Evensen, Olav Sletvold, Stian Lydersen, Kristin Taraldsen
BACKGROUND: Low level of physical activity is common among hospitalized older adults and is associated with worse prognosis. The aim of this paper is to describe the pattern and level of physical activity in a group of hospitalized older adults and to identify factors associated with physical activity. METHODS: We measured physical activity on day three after admission using accelerometer based activity monitors and time in upright position as outcome measure. We collected data of physical function (Short Physical Performance Battery, SPPB...
May 16, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28495537/impact-of-nutritional-state-on-critical-limb-ischemia-early-outcomes-denucriticc-study
#11
Lucie Salomon du Mont, Betty Leclerc, Marie-Catherine Morgant, Guillaume Besch, Aline Laubriet, Eric Steinmetz, Simon Rinckenbach
INTRODUCTION: Despite current progress, the prognosis of critical limb ischemia (CLI) remains poor. The ageing of the population, the increasing prevalence of diabetes mellitus, and the stability of tabacco use will increase the prevalence of CLI. CLI patients have risk factors for malnutrition and the impact of malnutrition on morbidity and mortality has been demonstrated in the general population. However, we have little information on the consequences of the consequences of undernutrition in the CLI population...
May 8, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28458958/the-intersection-of-oncology-prognosis-and-cancer-rehabilitation
#12
REVIEW
Sean Robinson Smith, Jasmine Yiqian Zheng
PURPOSE OF REVIEW: This review examines the delivery of rehabilitation care to cancer patients with relation to disease prognosis. This includes the evaluation when patients are referred for rehabilitation services and the effectiveness of rehabilitation interventions across the cancer continuum. RECENT FINDINGS: Although prognosticating life expectancy is difficult, referrals for rehabilitation interventions appear to be affected by physician attitudes towards patients with advanced disease, in part because of misconceptions about the nature of rehabilitation for oncology patients...
2017: Current Physical Medicine and Rehabilitation Reports
https://www.readbyqxmd.com/read/28451746/-renal-cell-carcinoma-in-older-and-geriatric-patients
#13
REVIEW
N Wagener
BACKGROUND: Renal cell carcinoma (RCC) is a disease of older humans. Due to increased detection of tumours by ultrasound and computed tomography, the number of incidentally diagnosed RCCs has increased. These tumours are usually smaller and of lower stage. Furthermore, there is an increase of older people in the population. OBJECTIVES: Characteristics of tumour biology, prognosis, diagnostics and therapy of localized, advanced and metastatic RCC in old and geriatric patients are provided...
April 27, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28433847/is-it-reliable-to-predict-the-outcome-of-elderly-patients-with-severe-traumatic-brain-injury-using-the-impact-prognostic-calculator
#14
Xueyan Wan, Kai Zhao, Sheng Wang, Huaqiu Zhang, Liang Zeng, Yu Wang, Lin Han, Rajluxmee Beejadhursing, Kai Shu, Ting Lei
BACKGROUND: Many investigators endeavor to predict the outcome based on admission characteristics using some established models to determine which management should be applied. However, the efficacy and applicability of the models using in the geriatric patients with severe traumatic brain injury (TBI) have not yet been evaluated. METHODS: A total of 137 geriatric severe TBI patients were enrolled in this retrospective study. Receiver operating characteristic (ROC) curves were constructed to evaluate the efficacy and usability of the International Mission for Prognosis and Analysis of Clinical Trials in TBI (IMPACT) prognostic model in evaluating the prognosis for these patients...
July 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28430145/the-association-of-ankle-brachial-index-protein-energy-wasting-and-inflammation-status-with-cardiovascular-mortality-in-patients-on-chronic-hemodialysis
#15
Hideki Ishii, Hiroshi Takahashi, Yasuhiko Ito, Toru Aoyama, Daisuke Kamoi, Takashi Sakakibara, Norio Umemoto, Yoshitaka Kumada, Susumu Suzuki, Toyoaki Murohara
Protein-energy wasting (PEW) is highly prevalent in hemodialysis (HD) patients. We investigated the association of abnormal ankle brachial index (ABI), PEW, and chronic inflammation status with clinical prognosis in HD patients. A total of 973 HD patients were enrolled and were followed-up for 8 years. As a marker of the PEW, geriatric nutritional risk index (GNRI) was used. Cut-off levels were 91.2 for GNRI defined from previous studies and 1.9 mg/L for C-reactive protein (CRP) as median value, respectively...
April 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28422904/a-comparison-of-prognosis-calculators-for-geriatric-trauma-a-prognostic-assessment-of-life-and-limitations-after-trauma-in-the-elderly-consortium-study
#16
Tarik David Madni, Akpofure Peter Ekeh, Scott C Brakenridge, Karen J Brasel, Bellal Joseph, Kenji Inaba, Brandon R Bruns, Jeffrey D Kerby, Joseph Cuschieri, M Jane Mohler, Paul A Nakonezny, Audra Clark, Jonathan Imran, Steven E Wolf, M Elizabeth Paulk, Ramona L Rhodes, Herb A Phelan
BACKGROUND: The nine-center Prognostic Assessment of Life and Limitations After Trauma in the Elderly consortium has validated the Geriatric Trauma Outcome Score (GTOS) as a prognosis calculator for injured elders. We compared GTOS' performance to that of the Trauma Injury Severity Score (TRISS) in a multicenter sample. METHODS: Three Prognostic Assessment of Life and Limitations After Trauma in the Elderly centers not submitting subjects to the GTOS validation study identified subjects aged 65 years to 102 years admitted from 2000 to 2013...
July 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28413223/chiropractic-management-of-a-geriatric-patient-with-idiopathic-neuralgic-amyotrophy-a-case-report
#17
Jordan Gliedt, Justin M Goehl, Derek P Smith, Clinton J Daniels
OBJECTIVE: The purpose of this paper is to describe chiropractic management of a patient with neuralgic amyotrophy (NA) and to provide discussion regarding presentation, differential diagnosis, management and prognosis of idiopathic NA. CASE PRESENTATION: An 85 year old Caucasian male presented to a chiropractic clinic with right periscapular and lateral rib cage pain. The patient had previously sought evaluation and treatment from multiple health care providers and underwent multiple interventions without relief...
March 2017: Journal of the Canadian Chiropractic Association
https://www.readbyqxmd.com/read/28413015/-what-to-do-before-a-hypervitaminia-b12-in-the-elderly
#18
REVIEW
Abrar-Ahmad Zulfiqar, Xavier Sui Seng, Elise Duhamel, Nadir Kadri, Jean Doucet, Emmanuel Andres
Hypervitanimia B12 is an early marker of serious pathologies. These include solid neoplasms, malignant blood diseases and acute/chronic hepatopathies. Hypervitaminemia B12 in geriatrics is thereby an indicator in the diagnosis and prognosis of these conditions.
March 2017: Soins. Gérontologie
https://www.readbyqxmd.com/read/28397814/subtypes-of-physical-frailty-latent-class-analysis-and-associations-with-clinical-characteristics-and-outcomes
#19
Li-Kuo Liu, Chao-Yu Guo, Wei-Ju Lee, Liang-Yu Chen, An-Chun Hwang, Ming-Hsien Lin, Li-Ning Peng, Liang-Kung Chen, Kung-Yee Liang
Frailty is a well-recognized geriatric syndrome with various definitions and conceptual frameworks. This study aimed to use latent class analysis to discover potential subtypes of pre-frail and frail older people. Data from the I-Lan Longitudinal Aging Study (ILAS), a community-based cohort study was used for analysis. Latent class analysis was applied to characterize classes or subgroups with different frailty phenotypes among ILAS participants targeting older adults aged 65 and above, capable of completing a 6-meter walk, without severe major or life threatening diseases, and not institutionalized...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28391586/swallowing-impairment-is-a-significant-factor-for-predicting-life-prognosis-of-elderly-at-the-end-of-life
#20
Koji Naruishi, Yasufumi Nishikawa
BACKGROUND: In end-of-life care of elderly, the decision of care plan including gastrostomy is difficult frequently because of insufficient knowledge relating the life prognosis of elderly. It is important the families to decide correctly the life prognosis of elderly with geriatric diseases. Our purpose is to examine the significant factors for predicting life prognosis of elderly in end-of-life care. METHODS: A total of 320 elderly patients was enrolled (male/female 151/169; averaged age: male 84...
April 8, 2017: Aging Clinical and Experimental Research
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