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Geriatric prognosis

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https://www.readbyqxmd.com/read/27911302/association-between-cognitive-status-before-surgery-and-outcomes-in-elderly-patients-with-hip-fracture-in-a-dedicated-orthogeriatric-care-pathway
#1
Lorene Zerah, Judith Cohen-Bittan, Mathieu Raux, Anthony Meziere, Cendrine Tourette, Christian Neri, Marc Verny, Bruno Riou, Frederic Khiami, Jacques Boddaert
BACKGROUND: Dementia is associated with a worse prognosis of hip fracture, but the impact of a dedicated geriatric care pathway on the prognosis of these patients has not been evaluated. OBJECTIVE: According to the cognitive status before surgery, our main objective was to compare mortality rate at 6 months; secondary outcomes were to compare in-hospital complications, the risk of new institutionalization, and the ability to walk at 6 months. METHODS: Between 2009 and 2015, all patients (>70 years) admitted after hip fracture surgery into a dedicated unit of peri-operative geriatric care were included: patients with dementia (DP), without dementia (NDP), and with cognitive status not determined (CSND)...
November 28, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27890486/towards-a-multidisciplinary-approach-to-understand-and-manage-obesity-and-related-diseases
#2
REVIEW
Stephan C Bischoff, Yves Boirie, Tommy Cederholm, Michael Chourdakis, Cristina Cuerda, Nathalie M Delzenne, Nicolaas E Deutz, Denis Fouque, Laurence Genton, Carmen Gil, Berthold Koletzko, Miguel Leon-Sanz, Raanan Shamir, Joelle Singer, Pierre Singer, Nanette Stroebele-Benschop, Anders Thorell, Arved Weimann, Rocco Barazzoni
Overnutrition and sedentary lifestyle result in overweight or obesity defined as abnormal or excessive fat accumulation that may impair health. According to the WHO, the worldwide prevalence of obesity nearly doubled between 1980 and 2008. In 2008, over 50% of both men and women in the WHO European Region were overweight, and approximately 23% of women and 20% of men were obese. Comprehensive diagnostic and therapeutic approaches should include nutritional treatment to favor the best metabolic and nutritional outcome, as well as to induce potential disease-specific benefits from selected nutritional regimens...
November 16, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27890293/avian-oncology-diseases-diagnostics-and-therapeutics
#3
REVIEW
Cecilia S Robat, Melanie Ammersbach, Christoph Mans
Companion birds are increasingly living longer due to improved husbandry, nutrition, and veterinary care. As a consequence, a growing number of geriatric disease conditions are diagnosed and managed by veterinarians. Awareness of bird owners of diagnostic and treatment options for neoplastic diseases in humans and domestic animals has led to increasing demand to provide advanced diagnostic and treatment modalities for companion birds diagnosed with neoplasia. Treatment remains challenging in many companion birds due to the lack of information regarding prognosis and efficacy of antineoplastic treatments in these species...
January 2017: Veterinary Clinics of North America. Exotic Animal Practice
https://www.readbyqxmd.com/read/27885512/clinicopathological-features-of-thyroid-cancer-in-the-elderly-compared-to-younger-counterparts-single-center-experience
#4
F D Dellal, D Özdemir, A A Tam, H Baser, H Tatli Dogan, O Parlak, R Ersoy, B Cakir
PURPOSE: The incidence of thyroid cancer is increased in elderly patients. It tends to be larger and have more aggressive characteristics in these patients. Our aim was to compare features of thyroid carcinoma in geriatric and non-geriatric patients. METHODS: In total, 933 patients with thyroid cancer were retrospectively reviewed. Thyroid functions, ultrasonography features of malignant nodules, cytological and histopathological findings and the rates of recurrence and persistence were compared in patients ≥65 and <65 years old...
November 24, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27885228/factors-associated-with-the-prognosis-of-elderly-patients-with-advanced-dementia-who-receive-palliative-care-from-geriatric-health-services-facilities
#5
Keizo Sakai, Yasuhiko Masuda, Kunio Miyanishi
AIM: The aim of the present study is to identify the factors associated with the prognosis of advanced dementia patients who are newly admitted to a geriatric health services facility. METHODS: This retrospective cohort study used data that were obtained on admission in the care-assessment of long-term care facility patients. The 177 participants with advanced dementia were admitted to our facility between 2006 and 2013. The association between the factors in the care-assessment and the three-month-mortality rates were examined throughout the year...
2016: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/27875713/prognostic-value-of-degree-and-types-of-anaemia-on-clinical-outcomes-for-hospitalised-older-patients
#6
Emma Riva, Riccardo Colombo, Guido Moreo, Sara Mandelli, Carlotta Franchi, Luca Pasina, Mauro Tettamanti, Ugo Lucca, Pier Mannuccio Mannucci, Alessandro Nobili
STUDY OBJECTIVE: This study investigated in a large sample of in-patients the impact of mild-moderate-severe anaemia on clinical outcomes such as in-hospital mortality, re-admission, and death within three months after discharge. METHODS: A prospective multicentre observational study, involving older people admitted to 87 internal medicine and geriatric wards, was done in Italy between 2010 and 2012. The main clinical/laboratory data were obtained on admission and discharge...
November 14, 2016: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27866858/clinical-variables-and-biomarkers-in-prediction-of-cognitive-impairment-in-patients-with-newly-diagnosed-parkinson-s-disease-a-cohort-study
#7
Anette Schrag, Uzma Faisal Siddiqui, Zacharias Anastasiou, Daniel Weintraub, Jonathan M Schott
BACKGROUND: Parkinson's disease is associated with an increased incidence of cognitive impairment and dementia. Predicting who is at risk of cognitive decline early in the disease course has implications for clinical prognosis and for stratification of participants in clinical trials. We assessed the use of clinical information and biomarkers as predictive factors for cognitive decline in patients with newly diagnosed Parkinson's disease. METHODS: The Parkinson's Progression Markers Initiative (PPMI) study is a cohort study in patients with newly diagnosed Parkinson's disease...
November 17, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27864240/new-horizons-in-orthostatic-hypotension
#8
REVIEW
James Frith, Steve W Parry
BACKGROUND: orthostatic hypotension (OH) is a common disabling condition associated with increased morbidity and mortality. Much of the evidence available is derived from younger populations with chronic neurological disease leading to uncertainty for the diagnosis and management of older people. OBJECTIVE: to provide an overview of recent and emerging evidence for the diagnosis, management and prognosis of OH in older persons. METHODS: a narrative review of recent studies, emerging therapies and relevant regulatory updates...
November 17, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27825697/geriatric-factors-analyses-from-ffcd-2001-02-phase-iii-study-of-first-line-chemotherapy-for-elderly-metastatic-colorectal-cancer-patients
#9
Thomas Aparicio, Dany Gargot, Laurent Teillet, Emilie Maillard, Dominique Genet, Jacques Cretin, Christophe Locher, Olivier Bouché, Gilles Breysacher, Jean-François Seitz, Mohamed Gasmi, Laetitia Stefani, Mohamed Ramdani, Thierry Lecomte, Dominique Auby, Roger Faroux, Jean-Baptiste Bachet, Céline Lepère, Faiza Khemissa, Iradj Sobhani, Olivier Boulat, Emmanuel Mitry, Jean-Louis Jouve
AIM: Several predictors of metastatic colorectal cancer (mCRC) outcomes have been described. Specific geriatric characteristics could be of interest to determine prognosis. METHOD: Elderly patients (75+) with previously untreated mCRC were randomly assigned to receive infusional 5-fluorouracil-based chemotherapy, either alone (FU) or in combination with irinotecan (IRI). Geriatric evaluations were included as an optional procedure. The predictive value of geriatric parameters was determined for the objective response rate (ORR), progression-free survival (PFS) and overall survival (OS)...
November 5, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27812251/comparative-evaluation-of-common-comorbidity-scores-and-freiburger-comorbidity-index-as-prognostic-variables-in-a-real-life-multiple-myeloma-population
#10
Birgul Onec, Harika Okutan, Murat Albayrak, Esra Sarıbacak Can, Vedat Aslan, Ozge Soyer Kosemehmetoglu, Basak Unver Koluman
Multiple myeloma (MM) is a disease of the geriatric population with a median age at diagnosis of 69 years but most clinicians consider performance status and comorbidities rather than chronological age in determining prognosis and treatment. The purpose of this study was to assess whether and which comorbidity indices predict survival in a real life population of MM. We calculated Charlson Comorbidity Index (CCI), age combined Charlson index (CCI-age), Hematopoietic cell transplantation-specific comorbidity index (HCT-SCI) and Freiburger comorbidity index (FCI) retrospectively for 66 MM patients and compared their impact on treatment responses and overall survival (OS)...
December 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27803007/management-of-chronic-lymphocytic-leukemia-cll-in-the-elderly-a-position-paper-from-an-international-society-of-geriatric-oncology-siog-task-force
#11
REVIEW
R Stauder, B Eichhorst, M Hamaker, K Kaplanov, V Morrison, A Österborg, I Poddubnaya, J A Woyach, T Shanafelt, L Smolej, L Ysebaert, V Goede
Chronic lymphocytic leukemia (CLL) mainly affects older people: the median age at diagnosis is above seventy years. Elderly patients with CLL are heterogeneous with regard both to the biology of their disease and aging. Following the diagnosis of CLL in an elderly individual, careful risk assessment is essential when treatment options are evaluated. This includes not only clinical staging and evaluation of disease-specific prognostic biomarkers such as 17p deletion and TP53 mutation, but also of comorbidities, physical capacity, nutritional status, cognitive capacity, ability to perform activities of daily living, and social support...
November 1, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27785002/european-society-for-swallowing-disorders-european-union-geriatric-medicine-society-white-paper-oropharyngeal-dysphagia-as-a-geriatric-syndrome
#12
REVIEW
Laura Wj Baijens, Pere Clavé, Patrick Cras, Olle Ekberg, Alexandre Forster, Gerald F Kolb, Jean-Claude Leners, Stefano Masiero, Jesús Mateos-Nozal, Omar Ortega, David G Smithard, Renée Speyer, Margaret Walshe
This position document has been developed by the Dysphagia Working Group, a committee of members from the European Society for Swallowing Disorders and the European Union Geriatric Medicine Society, and invited experts. It consists of 12 sections that cover all aspects of clinical management of oropharyngeal dysphagia (OD) related to geriatric medicine and discusses prevalence, quality of life, and legal and ethical issues, as well as health economics and social burden. OD constitutes impaired or uncomfortable transit of food or liquids from the oral cavity to the esophagus, and it is included in the World Health Organization's classification of diseases...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27727086/impact-of-geriatric-nutritional-risk-index-on-cardiovascular-outcomes-in-patients-with-stable-coronary-artery-disease
#13
Ayako Kunimura, Hideki Ishii, Tadayuki Uetani, Toshijirou Aoki, Kazuhiro Harada, Kenshi Hirayama, Yosuke Negishi, Yohei Shibata, Takuya Sumi, Kazuhiro Kawashima, Yosuke Tatami, Toshiki Kawamiya, Dai Yamamoto, Susumu Suzuki, Tetsuya Amano, Toyoaki Murohara
BACKGROUND: The association between malnutrition and cardiovascular prognosis in patients with stable coronary artery disease remains unclear. The aim of this study was to evaluate the association between Geriatric Nutritional Risk Index (GNRI), a simple tool to assess nutritional risk, and long-term outcomes after elective percutaneous coronary intervention (PCI). METHODS: This study consisted of 802 patients (age, 70±10 years, male, 69%) who underwent elective PCI...
October 7, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/27710987/prevalence-and-factors-associated-with-geriatric-malnutrition-in-an-outpatient-clinic-of-a-teaching-hospital-in-jeddah-saudi-arabia
#14
Sami Hamdan Alzahrani, Ismail Abdelmoneim El Sayed, Sarah Mohammed Alshamrani
BACKGROUND: Malnutrition is highly prevalent among the elderly and is associated with poor clinical prognosis, decreased functional status, and increased morbidity and mortality. OBJECTIVE: To estimate the prevalence of geriatric malnutrition among outpatients of a geriatric clinic and to determine factors associated with malnutrition. DESIGN: Cross-sectional study. SETTING: Geriatric outpatient clinic of the King Abdul Aziz University Hospital, Jeddah...
September 2016: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/27704168/adverse-drug-events-in-patients-with-advanced-chronic-conditions-who-have-a-prognosis-of-limited-life-expectancy-at-hospital-admission
#15
Daniel Sevilla-Sanchez, Núria Molist-Brunet, Jordi Amblàs-Novellas, Pere Roura-Poch, Joan Espaulella-Panicot, Carles Codina-Jané
PURPOSE: Adverse drug events (ADEs) lead to adverse clinical outcomes such as hospitalization. There is little information about the characteristics of ADEs in patients with advanced chronic conditions and have a prognosis of limited life expectancy. This study aimed to evaluate (i) the prevalence of ADEs at the time of admission to hospital, (ii) the causality, severity, and preventability of the ADEs, and (iii) the clinical and pharmacological characteristics associated with the ADEs...
October 4, 2016: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27682463/towards-a-definition-of-self-neglect-in-psychiatric-patients-descriptions-of-a-case-series
#16
Joanna Lamkin, Phuong T Nguyen, John H Coverdale, Mollie R Gordon
Self-neglect, although frequently studied in geriatric populations, has received only limited attention in psychiatric populations. To address this gap, we utilize a behavioral framework to present a set of case examples in order to illustrate the complex relationship between self-neglect behaviors and conditions and various psychiatric illness. Cases are discussed with respect to ascending severity of presentations of self-neglect in adult non-geriatric inpatient psychiatric populations. Self-neglect is conceptualized as a range of behaviors, as well as an overall condition that affects an individual's functioning in several major domains...
September 28, 2016: Psychiatric Quarterly
https://www.readbyqxmd.com/read/27661439/palliative-care-in-the-trauma-icu
#17
Kathleen O'Connell, Ronald Maier
PURPOSE OF REVIEW: The benefits of palliative care for critically ill patients are well recognized, yet acceptance into surgical culture is lagging. With the increasing proportion of geriatric trauma patients, integration of palliative medicine within daily intensive care services to facilitate goal-concordant care is imperative. RECENT FINDINGS: Misconceptions of palliative medicine as it applies to trauma patients linger among trauma surgeons and many continue to practice without routine consultation of a palliative care service...
December 2016: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/27647625/risk-factors-for-short-and-long-term-mortality-in-very-old-patients-with-clostridium-difficile-infection-a-retrospective-study
#18
Yaara Leibovici-Weissman, Alaa Atamna, Agata Schlesinger, Noa Eliakim-Raz, Jihad Bishara, Dafna Yahav
AIM: Most cases of Clostridium difficile infections (CDI) occur in patients aged 65 years and older. Older age is associated with increased mortality. Risk factors for mortality in patients aged 80 years and older are not well recognized. METHODS: We analyzed retrospective data including 184 patients aged 80 years and older hospitalized with CDI during 2009-2014. We aimed to delineate risk factors for short- and long-term mortality. RESULTS: The 30-day mortality was 33...
September 20, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27594414/c-reactive-protein-crp-measurement-in-geriatric-patients-hospitalized-for-acute-infection
#19
Andrea Ticinesi, Fulvio Lauretani, Antonio Nouvenne, Emanuela Porro, Guido Fanelli, Marcello Maggio, Tiziana Meschi
The physiology of inflammatory response is modified by the aging process and is substantially affected by multimorbidity and disability. Infection is the most frequent cause of acute inflammation in both adult and older subjects. C-reactive protein (CRP) is the most used biomarker of inflammation, and a substantial amount of literature has demonstrated its importance and clinical usefulness in adult subjects. However, the clinical significance of serum CRP determination has not been completely clarified in older subjects with acute infection, especially in the light of the age-related rearrangements in immunity and cytokine production...
September 1, 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/27579614/gbm-associated-mutations-and-altered-protein-expression-are-more-common-in-young-patients
#20
Sherise D Ferguson, Joanne Xiu, Shiao-Pei Weathers, Shouhao Zhou, Santosh Kesari, Stephanie E Weiss, Roeland G Verhaak, Raymond J Hohl, Geoffrey R Barger, Sandeep K Reddy, Amy B Heimberger
BACKGROUND: Geriatric glioblastoma (GBM) patients have a poorer prognosis than younger patients, but IDH1/2 mutations (more common in younger patients) confer a favorable prognosis. We compared key GBM molecular alterations between an elderly (age ≥ 70) and younger (18 < = age < = 45) cohort to explore potential therapeutic opportunities. RESULTS: Alterations more prevalent in the young GBM cohort compared to the older cohort (P < 0.05) were: overexpression of ALK, RRM1, TUBB3 and mutation of ATRX, BRAF, IDH1, and TP53...
August 25, 2016: Oncotarget
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