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Geriatric prognosis

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https://www.readbyqxmd.com/read/29685381/an-onco-geriatric-approach-to-select-older-patients-for-optimal-treatments-of-pancreatic-adenocarcinoma
#1
Elisabeth Castel-Kremer, Solene De Talhouet, Anne-Laure Charlois, Emmanuelle Graillot, Xavier Chopin-Laly, Mustapha Adham, Brigitte Comte, Catherine Lombard-Bohas, Thomas Walter, Gilles Boschetti
INTRODUCTION: Pancreatic adenocarcinoma affects mainly older patients. Surgery is indicated for localized tumors while chemotherapy alone is proposed in advanced or metastatic tumors. OBJECTIVE: To evaluate the feasibility of standard of care oncologic treatments in this population, the accuracy of the geriatric evaluation to predict the ability of patients to tolerate the recommended treatments and to identify specific geriatric prognosis factors. METHODS: We included, between 2007 and 2014, all consecutive patients over 70 years of age with a pathologically diagnosed pancreatic cancer...
April 20, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29650296/prognostic-usefulness-of-arm-circumference-and-nutritional-screening-tools-in-older-patients-with-cardiovascular-disease
#2
T Nakamura, K Kamiya, A Matsunaga, N Hamazaki, R Matsuzawa, K Nozaki, S Tanaka, M Yamashita, E Maekawa, C Noda, M Yamaoka-Tojo, T Masuda, J Ako
BACKGROUND AND AIM: Arm circumference (AC) and nutritional screening tools have been shown to have prognostic capability in patients with cardiovascular disease (CVD). This study aimed to compare the prognostic predictive capabilities of AC and nutritional screening tools in older patients with CVD. METHODS AND RESULTS: The study population consisted of 949 admitted patients ≥60 years old with CVD. Patients underwent AC measurement and nutritional screening before hospital discharge...
March 2, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29643881/urinary-tract-infections-in-the-geriatric-patients
#3
Yesim Alpay, Nevil Aykin, Pinar Korkmaz, Hakki Mustafa Gulduren, Figen Cevik Caglan
Objective: Urinary tract infections (UTI) are the second most common infection in geriatric population. This study investigated clinical findings, diagnostic approaches, complicating factors, prognosis, causative microorganisms and antimicrobial susceptibility in geriatric patients diagnosed with UTI. Methods: A total of 140 hospitalised patients with UTIs were evaluated within three years between January 2011-January 2015 at the Eskisehir Yunus Emre State Hospital...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29606980/short-overview-on-the-current-standard-of-treatment-in-newly-diagnosed-multiple-myeloma
#4
REVIEW
Ella Willenbacher, Agnes Balog, Wolfgang Willenbacher
The treatment of newly diagnosed multiple myeloma has changed dramatically over the past 20 years, from near uniform application of chemotherapy to a patient performance status- and risk-based approach. Furthermore, initiation of treatment criteria have evolved from a pure end-organ damage-based definition to include risk factors of transformation to frank myeloma. Besides, the mainly cytogenetically defined Multiple Myeloma (MM) risk status, transplant eligibility of patients still serves primarily to allocate patients within a rational treatment algorithm...
2018: Memo
https://www.readbyqxmd.com/read/29602015/geriatric-nutritional-risk-index-as-a-prognostic-factor-in-patients-with-esophageal-squamous-cell-carcinoma-retrospective-cohort-study
#5
Ippei Yamana, Shinsuke Takeno, Hideki Shimaoka, Kanefumi Yamashita, Teppei Yamada, Hironari Shiwaku, Tatsuya Hashimoto, Yuichi Yamashita, Suguru Hasegawa
PURPOSE: The Geriatric Nutritional Risk Index (GNRI) is a new index recently introduced to predict the risk of nutrition-related complications and mortality. Our aim is to examine the association between the GNRI and long-term prognosis in patients with esophageal squamous cell carcinoma (ESCC) who underwent esophagectomy. METHODS: The present study enrolled consecutive 216 patients with ESCC who underwent esophagectomy. The GNRI at admission to the hospital was calculated as follows: (1...
March 27, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29569404/clinical-predictors-of-alzheimer-s-disease-progression
#6
Nozomi Hishikawa, Yusuke Fukui, Mami Takemoto, Kota Sato, Jingwei Shang, Toru Yamashita, Yasuyuki Ohta, Koji Abe
AIM: Rates of disease progression differ among patients with Alzheimer's disease (AD), but prognostic predictions remain a challenge. We carried out a clinic-based retrospective study to investigate the clinical factors for AD progression. METHODS: The 748 AD patients, who attended our hospital for >1 year and were given the Mini-Mental State Examination (MMSE) at least three times, were divided into three groups according to the annual change rate of MMSE score (G): Aggravater group (G < -2), Stabler group (-2 ≤ G ≤ 2) and Improver group (2 < G)...
March 22, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29558928/the-relationship-between-poor-nutritional-status-and-progression-of-aortic-calcification-in-patients-on-maintenance-hemodialysis
#7
Teppei Okamoto, Shingo Hatakeyama, Hirotake Kodama, Hirotaka Horiguchi, Yuka Kubota, Koichi Kido, Masaki Momota, Shogo Hosogoe, Yoshimi Tanaka, Tooru Takashima, Fumitada Saitoh, Tadashi Suzuki, Chikara Ohyama
BACKGROUND: Although aortic calcification has a significant negative impact on prognosis in patients on hemodialysis (HD), risk factors for aortic calcification progression remain unclear. The aim of this study was to investigate the relationship between malnutrition and aortic calcification progression in patients on HD. METHODS: Between April 2015 and October 2016, we treated 232 patients on HD. Of those, we retrospectively evaluated data from 184 patients who had had regular blood tests and computed tomography (CT) scans...
March 20, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29507775/a-geriatric-patient-with-spinal-cord-injury-without-radiographic-abnormality-outcomes-and-causes
#8
Sevtap Acer, Ebru Karaca Umay, Fatma Nazlı, Ugur Onur Kasman, İbrahim Gündoğdu, Aytül Çakcı
Introduction: Although the prognosis of spinal cord injury without radiographic evidence of abnormality (SCIWORA) depends on the severity of the initial neurological damage, most patients with American Spinal Injury Association impairment scale grade D are expected to recover fully. Case presentation: An 85-year-old patient with SCIWORA and urinary incontinence, who did not produce the expected response to rehabilitation, displayed the central, peripheral, and autonomic nervous system findings together...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29499984/multidimensional-intervention-to-improve-the-short-term-prognosis-of-frail-elderly-patients-discharged-from-a-short-stay-unit-a-quasiexperimental-study
#9
C Fernández Alonso, M Fuentes Ferrer, M I Jiménez Santana, L Fernández Hernández, M de la Cruz García, J González Del Castillo, J J González Armengol, P Gil Gregorio, E Calvo Manuel, F J Martín-Sánchez
OBJECTIVE: To study the effect of a multidimensional intervention on the prognosis at 30 days for frail elderly patients discharged from a short-stay unit. MATERIAL AND METHOD: A quasiexperimental study was conducted with a historical control cohort. We included frail patients (Identification of Seniors at Risk score≥2) 75 years of age or older, discharged from an short-stay unit over 2 months in 2013 (control group) and in 2016 (intervention group). An intervention was conducted based on the activation of resources, based on the deficiencies detected after an abbreviated geriatric assessment, in conjunction with Primary Care...
February 27, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29475917/how-should-palliative-thoracic-radiotherapy-be-fractionated-for-octogenarians-with-lung-cancer
#10
Carsten Nieder, Rosalba Yobuta, Bård Mannsåker, Astrid Dalhaug
BACKGROUND/AIM: Geriatric oncology practice should be based on dedicated studies and real-world experience. Therefore, we evaluated survival outcomes after palliative thoracic radiotherapy in octogenarian patients with lung cancer and analyzed prognostic factors. PATIENTS AND METHODS: We carried out a retrospective analysis of 51 patients with a median age of 83 years. Three different fractionation regimens were compared: two fractions of 8.5 Gy, 10 fractions of 3 Gy, and higher doses than 30 Gy (maximum biologically equivalent dose in 2-Gy fractions (EQD2) was always lower than 50 Gy)...
March 2018: In Vivo
https://www.readbyqxmd.com/read/29459248/impact-of-comorbidity-and-frailty-on-prognosis-in-colorectal-cancer-patients-a-systematic-review-and-meta-analysis
#11
REVIEW
Daniel Boakye, Bettina Rillmann, Viola Walter, Lina Jansen, Michael Hoffmeister, Hermann Brenner
INTRODUCTION: Colorectal cancer (CRC) is largely diagnosed at old age, when comorbidities and frailty are common and might be important prognostic factors of CRC. We aimed to systematically review epidemiological evidence on the prognostic role of comorbidity and frailty in CRC patients. METHODS: We systematically searched the PubMed and Web of Science databases up to August 08, 2017 for observational studies that used a standardized index to assess comorbidity or frailty, investigated and reported odds ratios (OR) or hazard ratios (HR) of their associations with any of the following CRC prognostic outcomes: thirty-day, overall or CRC-specific mortality and disease-free or recurrence-free survival...
February 10, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29435967/-the-effect-of-age-on-the-prognosis-of-patients-with-traumatic-brain-injury-who-undergo-a-craniotomy-analysis-of-a-surgical-series
#12
I J Gilete-Tejero, H Z Ippolito-Bastidas, L M Bernal-Garcia, J Mata-Gomez, R Garcia-Moreno, M Ortega-Martinez, J M Cabezudo-Artero
INTRODUCTION: In our setting, the ageing of the population has led to management of traumatic brain injury (TBI) in the later stages of life becoming an increasingly frequent problem. AIM: To evaluate the association between age and the functional and survival prognosis of patients who have undergone surgery due to TBI. PATIENTS AND METHODS: We performed a retrospective analysis of a series of 404 patients submitted to surgery between the years 2000 and 2015: 144 youngsters (12-44 years), 77 adults (45-64 years), 148 geriatric patients (65-79 years) and 26 'super geriatric' patients (> 80 years)...
February 16, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29433992/changes-in-statin-prescription-patterns-in-patients-admitted-to-an-australian-geriatric-subacute-unit
#13
Samer Noaman, Omar Al-Mukhtar, Sheri Abramovic, Hanin Mohammed, Cheng Yee Goh, Claire Long, Christopher Neil, Edward Janus, Nicholas Cox, William Chan
BACKGROUND: Assessment of demographic and clinical factors influencing the decision of statin discontinuation in the elderly population admitted to subacute geriatric unit. The aim of this study is to assess the clinical factors impacting the decision-making process of statin discontinuation in the elderly. METHODS: We retrospectively assessed changes in statin discontinuation and prescription among patients (≥60 years old) discharged from a geriatric evaluation and management unit by reviewing hospital digital medical records at Western Health - The Williamstown Hospital over a 12-month period from 4 February 2012 until 4 February 2013 inclusive...
January 31, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29396234/nutritional-management-of-older-adults-with-gastrointestinal-cancers-an-international-society-of-geriatric-oncology-siog-review-paper
#14
REVIEW
Anna Rachelle Mislang, Samantha Di Donato, Joleen Hubbard, Lalit Krishna, Giuseppe Mottino, Federico Bozzetti, Laura Biganzoli
Malnutrition is one of the most common physical manifestations of gastrointestinal (GI) cancers and is often under-diagnosed and under-treated. Like cancers, malnutrition occurs more commonly in older adults, with potential negative consequences to quality of life, functional status, tolerance to treatment, and prognosis. Nutritional assessment and management require a proactive and systematic, multi-disciplinary approach. Early assessment, detection, and prompt intervention of cancer-associated malnutrition and cachexia are equally essential to achieve better quality nutritional care for older oncology patients...
January 22, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29396191/sarcopenia-in-parkinson-disease-comparison-of-different-criteria-and-association-with-disease-severity
#15
Davide L Vetrano, Maria S Pisciotta, Alice Laudisio, Maria R Lo Monaco, Graziano Onder, Vincenzo Brandi, Domenico Fusco, Beatrice Di Capua, Diego Ricciardi, Roberto Bernabei, Giuseppe Zuccalà
OBJECTIVES: In Parkinson disease (PD), sarcopenia may represent the common downstream pathway that from motor and nonmotor symptoms leads to the progressive loss of resilience, frailty, and disability. Here we (1) assessed the prevalence of sarcopenia in older adults with PD using 3 different criteria, testing their agreement, and (2) evaluated the association between PD severity and sarcopenia. DESIGN: Cross-sectional, observation study. SETTING: Geriatric day hospital...
January 30, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29387461/hypertension-and-frailty-syndrome-in-old-age-current-perspectives
#16
Izabella Uchmanowicz, Anna Chudiak, Beata Jankowska-Polańska, Robbert Gobbens
Hypertension is both a health problem and a financial one globally. It affects nearly 30 % of the general population. Elderly people, aged ≥65 years, are a special group of hypertensive patients. In this group, the overall prevalence of the disease reaches 60 %, rising to 70 % in those aged ≥80 years. In the elderly population, isolated systolic hypertension is quite common. High systolic blood pressure is associated with an increased risk of cardiovascular disease, cerebrovascular disease, peripheral artery disease, cognitive impairment and kidney disease...
November 2017: Cardiac failure review
https://www.readbyqxmd.com/read/29381733/prognostic-effects-of-delirium-motor-subtypes-in-hospitalized-older-adults-a-prospective-cohort-study
#17
Thiago Junqueira Avelino-Silva, Flavia Campora, Jose Antonio Esper Curiati, Wilson Jacob-Filho
OBJECTIVES: To investigate the association between delirium motor subtypes and hospital mortality and 12-month mortality in hospitalized older adults. DESIGN: Prospective cohort study conducted from 2009 to 2015. SETTING: Geriatric ward of a university hospital in Sao Paulo, Brazil. PARTICIPANTS: We included 1,409 consecutive admissions of acutely ill patients aged 60 years and over. We excluded admissions for end-of-life care, with missing data on the main variables, length of stay shorter than 48 hours, or when consent to participate was not given...
2018: PloS One
https://www.readbyqxmd.com/read/29380503/oral-function-as-an-indexing-parameter-for-mild-cognitive-impairment-in-older-adults
#18
Yutaka Watanabe, Hidenori Arai, Hirohiko Hirano, Shiho Morishita, Yuki Ohara, Ayako Edahiro, Masaharu Murakami, Hiroyuki Shimada, Takeshi Kikutani, Takao Suzuki
AIM: To investigate the association between mild cognitive impairment (MCI) and oral status, and to develop an oral-based screening index for MCI. METHODS: A cross-sectional study was carried out in a total of 5104 community-dwelling adults (aged ≥65 years) from the Obu Study of Health Promotion for the Elderly. Screening for MCI included a standardized personal interview, Mini-Mental State Examination, Geriatrics and Gerontology-Functional Assessment Tool (which included 8 tasks used to assess logical memory, word list memory, attention and executive function, processing speed, and visuospatial skill) and oral status...
January 30, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29362300/-prognostic-value-of-geriatric-screening-tools-in-elderly-cancer-patients
#19
Masahiro Takahashi
The elderly population is heterogeneous. Chronological age alone does not reflect heterogeneity in the aging process. It is recommended that elderly cancer patients should be evaluated for some form of geriatric assessment(GA)to detect problems, to predict treatment-related toxicities, to predict functional decline, to predict prognosis, and to assist in cancer treatment decisions. It was reported that functional status, nutritional status, mental status, polypharmacy, and comorbidity were independent prognostic factors for survival in elderly cancer patients...
January 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29362298/-risk-assessment-of-chemotherapy-for-the-elderly-patients-with-gastrointestinal-cancer
#20
Tetsuya Hamaguchi
The basic principles in the chemotherapeutic treatment of elderly colorectal cancer patients are similar to those of young people, but because of age-related organ function deterioration and comorbidities that are involved in life prognosis, there are risks of side effects in drug therapy. Considering the influence on the quality of life(QOL)is necessary. In the treatment guidelines, recommended initial chemotherapeutic options for unresectable colorectal cancer depends on whether the patient is appropriate for intensive therapy, but there are no criteria on how to divide...
January 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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