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https://www.readbyqxmd.com/read/29783075/mir-19a-negatively-regulated-the-expression-of-pten-and-promoted-the-growth-of-ovarian-cancer-cells
#1
Yuhong Wang, Shuzhen Zhao, Lihong Zhu, Quanle Zhang, Yanfang Ren
Ovarian cancer is the most lethal malignancy of the women genital tract. Exploring novel factors involved in the development of ovarian cancer and characterizing the molecular mechanisms by which regulate the tumorigenesis of ovarian cancer are quite necessary. Here, we found that miR-19a was highly expressed in ovarian cancer tissues and cell lines. Overexpression of miR-19a promoted the viability of ovarian cancer cells, while down-regulation of miR-19a inhibited the growth of ovarian cancer cells. To further understand the underlying molecular mechanism of miR-19a in regulating ovarian cancer cell growth, the downstream targets of miR-19a were predicted...
May 18, 2018: Gene
https://www.readbyqxmd.com/read/29782296/sexual-behaviors-attitudes-and-knowledge-about-sexually-transmitted-infections-a-cross-sectional-study-in-romania
#2
Alecsandra Iulia Grad, Simona Corina Senilă, Rodica Cosgarea, Alexandru Dumitru Tataru, Stefan Cristian Vesa, Mihaela Laura Vica, Horea Vladi Matei, Loredana Ungureanu
Sexually transmitted infections (STIs) are serious public health problems. Little is known about sex knowledge, attitudes, and sexual behaviors among young adults in Romania; an effective preventive campaigns should be based on an appropriate understanding of these factors. The aim of the present study was to obtain data about sexual behavior, attitudes, and knowledge about STIs among university students aged 18-25 in Romania. 3872 persons completed an internet-based questionnaire, advertised on Facebook, regarding sexual behavior, attitudes, and knowledge about STIs from January 28 to February 28, 2016...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29782184/the-growth-of-preantral-follicles-and-the-impact-of-different-supplementations-and-circumstances-a-review-study-with-focus-on-bovine-and-human-preantral-follicles
#3
Zahra Rajabi, Zunair Khokhar, Hossein Yazdekhasti
One of the most important concerns cancer survivors face is fertility. Current treatment modalities often result in damage to the reproductive system. Different options have been proposed to preserve the fertility of affected women, and many attempts have been made to improve their chance of childbearing after therapy. Cryopreservation of ovarian tissue and follicles before the onset of cancer treatment and then either transplantation of ovarian tissue or culture of ovarian tissue and individual follicles in vitro is a commonly cited approach...
May 21, 2018: Cellular Reprogramming
https://www.readbyqxmd.com/read/29782074/supporting-women-at-the-time-of-abortion-a-mixed-methods-study-of-male-partner-experiences-and-perspectives
#4
Brian T Nguyen, Luciana E Hebert, Sara L Newton, Melissa L Gilliam
CONTEXT: Although men are commonly viewed as unaware, uninvolved and even obstructive regarding their partner's abortion access, those who accompany women to an abortion appointment may be more supportive. A better understanding of men's motivations could inform clinic policies regarding their involvement. METHODS: In 2015-2016, data were collected from male partners of women seeking an abortion at two clinics in a large Midwestern city. Twenty-nine interviews were conducted to explore how men wanted to be involved in the abortion and why they accompanied their partners...
May 21, 2018: Perspectives on Sexual and Reproductive Health
https://www.readbyqxmd.com/read/29781969/an-ecological-approach-toward-prevention-and-care-of-victims-of-domestic-minor-sex-trafficking
#5
Rosario V Sanchez, Dula F Pacquiao
Sex trafficking is a widespread form of human trafficking that exists globally. The forced sexual exploitation of young women for profit at the hands of traffickers is a human rights violation. Sex trafficking is a form of modern-day slavery where youths are sold as a commodity. It is difficult to determine the wide range of negative health outcomes associated with domestic minor sex trafficking due to the hidden nature of the crime and its lack of statistical data to determine prevalence. Viewing domestic minor sex trafficking through an ecological lens assists in the understanding of the multiple complex interactions between victims, their relationships, and environments that influence their health...
April 2018: Journal of Forensic Nursing
https://www.readbyqxmd.com/read/29781784/-being-connected-the-experience-of-african-american-women-with-breast-cancer-a-community-based-participatory-research-project-part-i
#6
M Tish Knobf, Diane Erdos
The objective was to understand the breast cancer experience of African American (AA) women using a community-based participatory research framework. Qualitative data were collected from five focus groups with 29 participants in four urban cities. "Being Connected" was the major theme that explained the importance of people in their lives as they coped with the diagnosis, treatment, and life after therapy. Faith, talking, information, support, and living with changes were important factors in the process...
May 21, 2018: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/29781723/strengths-in-older-adults-differential-effect-of-savoring-gratitude-and-optimism-on-well-being
#7
Isabel María Salces-Cubero, Encarnación Ramírez-Fernández, Ana Raquel Ortega-Martínez
Objetive: The present study aimed to compare the efficacy of three separate strengths training-based interventions - Gratitude, Savoring, and Optimism - in older adults. METHOD: The sample comprised 124 older adults, namely, 74 women and 50 men, non-institutionalized individuals who regularly attend day centers in the provinces of Jaén and Córdoba, southern Spain. Their ages ranged between 60 and 89 years. The measures used were Anxiety, Depression, Life Satisfaction, Positive and Negative Affect, Subjective Happiness, and Resilience...
May 21, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29781714/happy-life-expectancy-and-correlates-of-happiness-among-older-adults-in-south-africa
#8
Witness Chirinda, Nancy Phaswana-Mafuya
OBJECTIVES: This paper examines factors associated with happiness and to estimate happy life expectancy for older people in South Africa. METHODS: The study uses data from the first wave of the Study on Ageing and Adult Health (SAGE) survey, which is a nationally representative population-based survey with a sample of 3,840 individuals aged 50 years and above. The Sullivan method and multivariate linear regression analysis were used in the analysis. RESULTS: The prevalence of happiness was the same for men (55...
May 21, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29781414/prevalence-of-human-papillomavirus-types-associated-with-cervical-lesions-in-sergipe-state-northeastern-brazil-high-frequency-of-a-possibly-carcinogenic-type
#9
I G S S Serra, E D Araujo, G S Barros, F L S G Santos, R Q Gurgel, M V A Batista
Persistent infection with high-risk human papillomavirus (HPV) is the main cause of cervical cancer and the prevalence of HPV types varies depending on the geographic region. Therefore, this study assessed the prevalence of HPV types in women with cervical lesions from Sergipe state, Northeastern Brazil. A cross-sectional study was conducted in women with cervical lesions from March to December 2014. These lesions were investigated by PCR and HPV types were identified by DNA sequencing. 432 patients were included, of which 337 patients tested positive for HPV...
May 21, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29781100/factors-associated-with-breast-mri-use-among-women-with-a-family-history-of-breast-cancer
#10
Mary C White, Ashwini Soman, Clarice R Weinberg, Juan L Rodriguez, Susan A Sabatino, Lucy A Peipins, Lisa DeRoo, Hazel B Nichols, M Elizabeth Hodgson, Dale P Sandler
Although annual breast magnetic resonance imaging (MRI) is recommended for women at high risk for breast cancer as an adjunct to screening mammography, breast MRI use remains low. We examined factors associated with breast MRI use in a cohort of women with a family history of breast cancer but no personal cancer history. Study participants came from the Sister Study cohort, a nationwide, prospective study of women with at least 1 sister who had been diagnosed with breast cancer but who themselves had not ever had breast cancer (n = 17 894)...
May 20, 2018: Breast Journal
https://www.readbyqxmd.com/read/29779581/evidence-from-animal-models-on-the-pathogenesis-of-pcos
#11
REVIEW
K A Walters, M J Bertoldo, D J Handelsman
Polycystic ovarian syndrome (PCOS) is the most common endocrine condition in women, and is characterized by reproductive, endocrine and metabolic features. However, there is no simple unequivocal diagnostic test for PCOS, its etiology remains unknown and there is no cure. Hence, the management of PCOS is suboptimal as it relies on the ad hoc empirical management of its symptoms only. Decisive studies are required to unravel the origins of PCOS, but due to ethical and logistical reasons these are not possible in humans...
June 2018: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29779580/animal-models-of-endometriosis-replicating-the-aetiology-and-symptoms-of-the-human-disorder
#12
REVIEW
Ioannis Simitsidellis, Douglas A Gibson, Philippa T K Saunders
Endometriosis is a chronic incurable disorder that affects 1 in 10 women of reproductive age: associated symptoms include chronic pain and infertility. The aetiology of endometriosis remains poorly understood but patients, clinicians and researchers are all in agreement that new non-surgical therapies are urgently needed to reduce the severity of symptoms. Preclinical testing of drugs requires the development and validation of models that recapitulate the key features of the disorder. In this review we describe the best-validated animal models (primate, rodent, xenograft) and their contributions to our understanding of the factors underpinning the development of symptoms...
June 2018: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29779511/preconception-care-for-the-patient-and-family
#13
REVIEW
Elizabeth Hall, Robingale Panepinto, Elizabeth Keeley Bowman
Preconception counseling is essential for women of childbearing age and family members who have decided to conceive because the level of well health of the mother and unborn child are affected by decisions and actions of the mother before and during pregnancy. Proactively planning pregnancy includes scheduling a preconception counseling consultation with a provider. Understanding physical, psychological, and emotional needs promotes healthy pregnancy outcomes for mother and baby. This article offers a reflective and holistic perspective of how health care providers frame, prioritize, and engage with the patient and family during the preconception consultation...
June 2018: Nursing Clinics of North America
https://www.readbyqxmd.com/read/29779415/male-circumcision-for-hiv-prevention-female-risk-compensatory-behaviour-in-south-africa
#14
Clare Greevy, Rebecca King, Firoza Haffejee
South Africa promotes male circumcision (MC) as an HIV prevention method and implemented a national plan to scale-up MC in the country from 2012 to 2016. Literature has suggested that female risk compensatory behaviours (RCBs) are occurring in countries where these programmes have been implemented. Behaviours such as decreased condom use, concurrent sexual partners and sexual activity during the circumcision wound-healing period have the potential to jeopardise the campaigns' objectives. Literature has shown that directly providing women with MC information results in correct knowledge however, previous studies have not directly sought women's views and ideas on engagement with the information...
May 20, 2018: AIDS Care
https://www.readbyqxmd.com/read/29779012/adaptive-frameworks-of-chronic-pain-daily-remakings-of-pain-and-care-at-a-somali-refugee-women-s-health-centre
#15
Kari Campeau
Pain is an intensely subjective experience and one that is difficult for healthcare professionals to treat. Chronic pain, often diffuse, cyclical and involving many systems of the body, is often not well treated in a medical system that relies on discrete symptoms, identifiable causes, external pathogens and physician specialisation. Pain has its own problems specific to Somali diaspora populations, where chronic pain is prevalent but often undertreated, and where Somali patients face barriers of access to medicine...
May 19, 2018: Medical Humanities
https://www.readbyqxmd.com/read/29778641/subregional-volumes-of-the-hippocampus-in-relation-to-cognitive-function-and-risk-of-dementia
#16
Tavia E Evans, Hieab H H Adams, Silvan Licher, Frank J Wolters, Aad van der Lugt, M Kamran Ikram, Michael J O'Sullivan, Meike W Vernooij, M Arfan Ikram
BACKGROUND: Total hippocampal volume has been consistently linked to cognitive function and dementia. Yet, given its complex and parcellated internal structure, the role of subregions of the hippocampus in cognition and risk of dementia remains relatively underexplored. We studied subregions of the hippocampus in a large population-based cohort to further understand their role in cognitive impairment and dementia risk. METHODS: We studied 5035 dementia- and stroke-free persons from the Rotterdam Study, aged over 45 years...
May 17, 2018: NeuroImage
https://www.readbyqxmd.com/read/29778391/matrix-metalloproteinases-and-their-inhibitors-in-human-cumulus-and-granulosa-cells-as-biomarkers-for-oocyte-quality-estimation
#17
Alice Luddi, Martina Gori, Camilla Marrocco, Angela Capaldo, Valentina Pavone, Laura Bianchi, Letizia Boschi, Giuseppe Morgante, Paola Piomboni, Vincenzo de Leo
OBJECTIVE: To study the molecular profile of metalloproteinases and their tissue inhibitors in granulosa and cumulus cells in a subset of fertile and infertile women. DESIGN: Molecular study with granulosa and cumulus cells. SETTING: University hospital. PATIENT(S): Forty-four women undergoing assisted reproductive techniques for female infertility factor, with partners having a normal spermiogram and 15 normally fertile women with male partner affected by severe oligoasthenoteratozoospermia or nonobstructive azoospermia...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29778345/health-literacy-and-uptake-of-anti-fracture-medications-in-a-population-based-sample-of-australian-women
#18
Sarah M Hosking, Sharon L Brennan-Olsen, Alison Beauchamp, Rachelle Buchbinder, Lana J Williams, Julie A Pasco
This study investigated associations between health literacy and use of anti-fracture medications in women with osteoporosis. Data were collected for women participating in the population-based Geelong Osteoporosis Study in Australia. Health literacy was ascertained using the Health Literacy Questionnaire (HLQ) and bone mineral density by dual x-ray absorptiometry. Self-reported current medications were classified using MIMS codes, with the category 'Agent affecting calcium and bone metabolism' indicating osteoporosis treatment...
May 9, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29778270/is-female-health-cyclical-evolutionary-perspectives-on-menstruation
#19
REVIEW
Alexandra Alvergne, Vedrana Högqvist Tabor
Why do some females menstruate at all? Answering this question has implications for understanding the tight links between reproductive function and organismal immunity. Here we build on the growing evidence that menstruation is the byproduct of a 'choosy uterus' to: (i) make the theoretical case for the idea that female immunity is cyclical in menstruating species, (ii) evaluate the evidence for the menstrual modulation of immunity and health in humans, and (iii) speculate on the implications of cyclical female health for female behaviour, male immunity, and host-pathogen interactions...
June 2018: Trends in Ecology & Evolution
https://www.readbyqxmd.com/read/29778233/female-specific-association-among-i-j-and-k-mitochondrial-genetic-haplogroups-and-cancer-a-longitudinal-cohort-study
#20
Claudio Luchini, Alessia Nottegar, Alberto Vaona, Brendon Stubbs, Jacopo Demurtas, Stefania Maggi, Nicola Veronese
Recent studies highlighted the role of mitochondrial dysregulation in cancer, suggesting that the different mitochondrial haplogroups might play a role in tumorigenesis and risk of cancer development. Our aim is to investigate whether any mitochondrial haplogroups carried a significant higher risk of cancer development in a large prospective cohort of North American people. The haplogroup assignment was performed by a combination of sequencing and PCR-RFLP techniques. Our specific outcome of interest was the incidence of any cancer during follow-up period...
August 2018: Cancer Genetics
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