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https://www.readbyqxmd.com/read/28938739/sequence-variants-of-khdrbs1-as-high-penetrance-susceptibility-risks-for-primary-ovarian-insufficiency-by-mis-regulating-mrna-alternative-splicing
#1
Binbin Wang, Lin Li, Ying Zhu, Wei Zhang, Xi Wang, Beili Chen, Tengyan Li, Hong Pan, Jing Wang, Kehkooi Kee, Yunxia Cao
STUDY QUESTION: Does a novel heterozygous KHDRBS1 variant, identified using whole-exome sequencing (WES) in two patients with primary ovarian insufficiency (POI) in a pedigree, cause defects in mRNA alternative splicing? SUMMARY ANSWER: The heterozygous variant of KHDRBS1 was confirmed to cause defects in alternative splicing of many genes involved in DNA replication and repair. WHAT IS KNOWN ALREADY: Studies in mice revealed that Khdrbs1 deficient females are subfertile, which manifests as delayed sexual maturity and significantly reduced numbers of secondary and pre-antral follicles...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938488/ovarian-aging-in-women-with-brca-germline-mutations
#2
Wayne Lin, Shiny Titus, Fred Moy, Elizabeth S Ginsburg, Kutluk Oktay
Context: Recent clinical and laboratory studies suggested that women with BRCA mutations have lower ovarian reserve and their primordial follicle oocytes may be more prone to DNA damage but the direct proof is lacking. Objective: To determine whether women with germline BRCA mutations have reduced primordial follicle reserve and increased oocyte DNA damage. Design: A laboratory comparative study of ovarian tissue obtained from the risk-reducing salpingo- oophorectomy (RRSO) samples of unaffected BRCA mutation carrier (BMC) women vs...
August 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938077/one-step-for-a-hospital-ten-steps-for-women-african-american-women-s-experiences-in-a-newly-accredited-baby-friendly-hospital
#3
Elizabeth M Miller, Adetola F Louis-Jacques, Tara F Deubel, Ivonne Hernandez
BACKGROUND: Despite strides made by the Baby-Friendly Hospital Initiative to improve and normalize breastfeeding, considerable racial inequality persists in breastfeeding rates. Few studies have explored African American women's experience in a Baby-Friendly Hospital Initiative system to understand sources of this inequality. Research aim: This study aimed to explore African American women's experiences of the Ten Steps to Successful Breastfeeding at a women's center associated with a university-affiliated hospital that recently achieved Baby-Friendly status...
September 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28938047/diversity-in-the-us-infectious-diseases-workforce-challenges-for-women-and-underrepresented-minorities
#4
Judith A Aberg, Joel Blankson, Jeanne Marrazzo, Adaora A Adimora
Research documents significant gender-based salary inequities among physicians and ongoing inadequacies in recruitment and promotion of physicians from underrepresented minority groups. Given the complexity of the social forces that promote these disparities, their elimination will likely require quantitative and qualitative research to understand the pathways that lead to them and to develop effective solutions. Interventions to combat implicit bias will be required, and structural interventions that hold medical school leadership accountable are needed to achieve and maintain salary equity and racial and gender diversity at all levels...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28937804/obesity-and-endometrial-cancer-a-lack-of-knowledge-but-opportunity-for-intervention
#5
Ashley F Haggerty, David B Sarwer, Kathryn H Schmitz, Emily M Ko, Kelly C Allison, Christina S Chu
OBJECTIVE: The causal link between obesity and endometrial cancer is well established; however obese women's knowledge of this relationship is unknown. Our objective was to explore patients' understanding of this relationship and assess the acceptability of a technology-based weight loss intervention. METHODS/MATERIALS: Obese women with Type I endometrial cancer/hyperplasia were surveyed about their assessment of their body mass, knowledge of the relationship of obesity and endometrial cancer, and eating and activity habits...
September 22, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28937790/the-doctor-of-philosophy-experience-of-athletic-trainers-facilitators-and-barriers-to-anticipatory-faculty-socialization
#6
Thomas Bowman, Joanne Klossner, Stephanie Mazerolle
CONTEXT:   It is important to understand the process whereby athletic trainers learn about their future roles, particularly when the roles can be complex and demanding. Little is known about the experiences of athletic training doctoral students, including facilitators and barriers to socialization as aspiring faculty members. OBJECTIVE:   To investigate factors influencing the anticipatory socialization of athletic training doctoral students into future faculty roles...
September 22, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28937512/obstetricians-and-gynecologists-of-the-future-a-survey-of-medical-students-applying-to-residency
#7
Meredith J Alston, Amy Meg Autry, Sarah A Wagner, Abigail Winkel, Amanda A Allshouse, Alyssa Stephenson-Famy
OBJECTIVE: To understand the characteristics and career goals of medical students selecting a career in obstetrics and gynecology. METHODS: In 2015-2016, medical students invited for interviews for obstetrics and gynecology residency at the University of Colorado, University of Washington, University of California San Francisco, Loyola University, and New York University received a voluntary 20-item electronic survey regarding factors influencing their choice of medical specialty...
October 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28937036/socioeconomic-and-environmental-determinants-to-preterm-birth-in-tibetan-women-an-analysis-based-on-the-hierarchically-conceptual-frame
#8
Xiao-Jing Fan, Jian-Min Gao, Yi-Jun Kang, Shao-Nong Dang, Wei-Hua Wang, Hong Yan, Duo-Lao Wang
BACKGROUND: Preterm birth is a common cause of death in newborns and may result from many determinants, but evidence for the socioeconomic and environmental determinants of preterm birth in Tibetan women of childbearing age is limited. The aim of this study was to understand the current status of preterm birth in native Tibetan women and investigate the socioeconomic and environmental determinants. METHODS: Data were drawn from a cohort study which was conducted from August 2006 to August 2012 in rural Lhasa, Tibet, China...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28936431/syndemic-risk-classes-and-substance-use-problems-among-adults-in-high-risk-urban-areas-a-latent-class-analysis
#9
Charles M Cleland, Stephanie T Lanza, Sara A Vasilenko, Marya Gwadz
Substance use problems tend to co-occur with risk factors that are especially prevalent in urban communities with high rates of poverty. The present study draws on Syndemics Theory to understand profiles of risk and resilience and their associations with substance use problems in a population at risk for adverse outcomes. African-American/Black and Hispanic heterosexual adults (N = 2,853) were recruited by respondent-driven sampling from an urban area with elevated poverty rates, and completed a structured assessment battery covering sociodemographics, syndemic factors (that is, multiple, co-occurring risk factors), and substance use...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28936028/social-support-and-postpartum-depression-revisited-the-traditional-female-role-as-moderator-among-mexican-women
#10
Analia F Albuja, M Asunción Lara, Laura Navarrete, Lourdes Nieto
Women who lack social support tend to have a higher risk of postpartum depression. The present study examined the traditional female role, understood here as the adoption of passive and submissive traits specific to Mexican women, as another risk factor for postpartum depressive symptomatology that interacts with social support. Using two waves of data from a longitudinal study of 210 adult Mexican women (20-44 years-old, Mage = 29.50 years, SD = 6.34), we found that lacking social support during the third trimester of their pregnancy was associated with greater depressive symptoms at 6 months in the postpartum, although this relationship depended on the level of endorsement of the traditional female role during pregnancy...
August 2017: Sex Roles
https://www.readbyqxmd.com/read/28935360/when-guidelines-conflict-a-case-study-of-mammography-screening-initiation-in-the-1990s
#11
Mireille Jacobson, Srikanth Kadiyala
BACKGROUND: Cancer screening guidelines communicate important information to patients and physicians regarding the costs and benefits of screening. Currently, guideline recommendations from major organizations conflict regarding the age of mammography screening initiation. To understand current and future U.S. mammography screening patterns we study age-mammography patterns from the 1990s, another period of conflicting guideline recommendations. METHODS: We examine mammography use rates by single year of age to understand compliance with guideline-recommended initiation ages in the 1990s...
September 18, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28934940/human-development-index-hdi-of-the-maternal-country-of-origin-as-a-predictor-of-perinatal-outcomes-a-longitudinal-study-conducted-in-spain
#12
S Garcia-Tizon Larroca, J Arevalo-Serrano, A Duran Vila, M P Pintado Recarte, I Cueto Hernandez, A Solis Pierna, S Lizarraga Bonelli, J De Leon-Luis
BACKGROUND: In an era of worldwide population displacement, recent studies have identified strong associations between social situations and perinatal outcomes among immigrants. Little is known about the effect of maternal social background on pregnancy outcomes. The Human Development Index (HDI) assesses the following dimensions of human development: life expectancy, education level and income. The objective of our study was to determine if maternal HDI may be used to identify women at increased odds of poor pregnancy outcomes...
September 21, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28934899/knowledge-about-and-attitude-towards-fertility-preservation-in-young-female-cancer-patients-a-cross-sectional-online-survey
#13
Corinne Urech, Verena Ehrbar, Jacky Boivin, Madleina Müller, Judith Alder, Rosanna Zanetti Dällenbach, Christoph Rochlitz, Sibil Tschudin
Recent advances in cancer therapy have resulted in an increased number of long-term cancer survivors. However, because of their treatment, women might be confronted with impaired fertility. The options of fertility preservation (FP) techniques are increasing. The goal of this study was to assess knowledge about, and attitudes towards, fertility preservation in young female cancer patients. A cross-sectional online survey was conducted including 155 former female cancer patients from English and German speaking countries...
September 22, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28934767/family-planning-unmet-need-and-access-among-itaukei-women-in-new-zealand-and-fiji
#14
Radilaite Cammock, Peter Herbison, Sarah Lovell, Patricia Priest
AIM: The aim of the study was to identify unmet need and family planning access among indigenous Fijian or iTaukei women living in New Zealand and Fiji. METHOD: A cross-sectional survey was undertaken between 2012-2013 in five major cities in New Zealand: Auckland, Hamilton, Wellington, Christchurch and Dunedin; and in three suburbs in Fiji. Women who did not want any (more) children but were not using any form of contraception were defined as having an unmet need...
September 22, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28934632/in-vivo-biomechanical-behavior-of-the-trapeziometacarpal-joint-in-healthy-and-osteoarthritic-subjects
#15
Priscilla D'Agostino, Benjamin Dourthe, Faes Kerkhof, G Harry Van Lenthe, Filip Stockmans, Evie E Vereecke
BACKGROUND: The contact biomechanics of the trapeziometacarpal joint have been investigated in several studies. However, these led to conflicting results and were mostly performed in vitro. The purpose of this study was to provide further insight on the contact biomechanics of the trapeziometacarpal joint by in vivo assessment of healthy and osteoarthritic subjects. METHODS: The hands of 16 healthy women and 6 women with trapeziometacarpal osteoarthritis were scanned in positions of maximal thumb extension, flexion, abduction and adduction during three isometric tasks (lateral key pinch, power grasp and jar twist) and in thumb rest posture (relaxed neutral)...
September 12, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28934309/increased-plasma-proline-concentrations-are-associated-with-sarcopenia-in-the-elderly
#16
Kenji Toyoshima, Marie Nakamura, Yusuke Adachi, Akira Imaizumi, Tomomi Hakamada, Yasuko Abe, Eiji Kaneko, Soiciro Takahashi, Kentaro Shimokado
BACKGROUND AND PURPOSE: Metabolome analyses have shown that plasma amino acid profiles reflect various pathological conditions, such as cancer and diabetes mellitus. It remains unclear, however, whether plasma amino acid profiles change in patients with sarcopenia. This study therefore aimed to investigate whether sarcopenia-specific changes occur in plasma amino acid profiles. METHODS: A total of 153 community-dwelling and seven institutionalized elderly individuals (56 men, 104 women; mean age, 77...
2017: PloS One
https://www.readbyqxmd.com/read/28934183/trends-in-cervical-cancer-screening-in-title-x-funded-health-centers-united-states-2005-2015
#17
Christina I Fowler, Mona Saraiya, Susan B Moskosky, Jacqueline W Miller, Julia Gable, Nancy Mautone-Smith
Cervical cancer screening is critical to early detection and treatment of precancerous cells and cervical cancer. In 2015, 83% of U.S. women reported being screened per current recommendations, which is below the Healthy People 2020 target of 93% (1,2). Disparities in screening persist for women who are younger (aged 21-30 years), have lower income, are less educated, are uninsured, lack a source of health care, or who self-identify as Asian or American Indian/Alaska Native (2). Women who are never screened or rarely screened are more likely to develop cancer and receive a cancer diagnosis at later stages than women who are screened regularly (3)...
September 22, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28934151/natural-history-of-hpv-infection-across-the-lifespan-role-of-viral-latency
#18
REVIEW
Patti E Gravitt, Rachel L Winer
Large-scale epidemiologic studies have been invaluable for elaboration of the causal relationship between persistent detection of genital human papillomavirus (HPV) infection and the development of invasive cervical cancer. However, these studies provide limited data to adequately inform models of the individual-level natural history of HPV infection over the course of a lifetime, and particularly ignore the biological distinction between HPV-negative tests and lack of infection (i.e., the possibility of latent, undetectable HPV infection)...
September 21, 2017: Viruses
https://www.readbyqxmd.com/read/28933950/women-s-experiences-of-pornography-a-systematic-review-of-research-using-qualitative-methods
#19
Sarah Ashton, Karalyn McDonald, Maggie Kirkman
Given the proliferation of pornography in personal, relational, and social realms, it is vital to understand women's experiences of this accessible, stimulating, and versatile sexual material. We therefore conducted the first systematic review of research using qualitative methods published in English in peer-reviewed journals. Our search of five databases yielded 22 eligible articles. Thematic analysis of results revealed four broad themes: women encountering pornography, pornography and the self, pornography in the context of relationships, and making sense of pornography...
September 21, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/28933870/the-role-of-young-adult-social-bonds-substance-problems-and-sexual-risk-in-pathways-between-adolescent-substance-use-and-midlife-risky-sexual-behavior-among-urban-african-americans
#20
Katarzyna A Zebrak, Kerry M Green
African Americans are disproportionately affected by HIV/AIDS and other sexually transmitted infections relative to other racial groups. Although substance use has been linked to risky sexual behavior, the understanding of how these associations develop over the life course remains limited, particularly the role of social bonds. This study uses structural equation modeling to examine pathways from adolescent substance use to young adult sexual risk, substance problems, and social bonds and then to midlife risky sexual behavior among African American men and women, controlling for childhood confounders...
September 21, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
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