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transient elastography

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https://www.readbyqxmd.com/read/28791501/skeletal-muscle-mass-to-visceral-fat-area-ratio-is-an-important-determinant-affecting-hepatic-conditions-of-non-alcoholic-fatty-liver-disease
#1
Takashi Shida, Kentaro Akiyama, Sechang Oh, Akemi Sawai, Tomonori Isobe, Yoshikazu Okamoto, Kazunori Ishige, Yuji Mizokami, Kenji Yamagata, Kojiro Onizawa, Hironori Tanaka, Hiroko Iijima, Junichi Shoda
BACKGROUND: Not only obesity but also sarcopenia is associated with NAFLD. The influence of altered body composition on the pathophysiology of NAFLD has not been fully elucidated. The aim of this study is to determine whether skeletal muscle mass to visceral fat area ratio (SV ratio) affects NAFLD pathophysiology. METHODS: A total of 472 subjects were enrolled. The association between SV ratio and NAFLD pathophysiological factors was assessed in a cross-sectional nature by stratification analysis...
August 8, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28790227/evaluation-of-acoustic-radiation-force-impulse-arfi-for-fibrosis-staging-in-chronic-liver-diseases
#2
Rino Alvani Gani, Irsan Hasan, Andri Sanityoso, Cosmas Rinaldi A Lesmana, Juferdy Kurniawan, Chyntia Olivia Maurine Jasirwan, Kemal Fariz Kalista, Lutfie Lutfie
BACKGROUND: acoustic radiation force impulse (ARFI) is a new proposed noninvasive method for liver fibrosis staging. Integrated with B-mode ultrasonography, ARFI can be used to assess liver tissue condition. However its diagnostic accuracy is still being continuously evaluated. Also, there is lack of data regarding the utilization of ARFI in our population. This study aimed to evaluate the diagnostic value of ARFI as an alternative noninvasive modality for fibrosis staging in chronic hepatitis B and hepatitis C patients in our population...
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28790222/prevalence-and-profile-of-fibrosis-in-diabetic-patients-with-non-alcoholic-fatty-liver-disease-and-the-associated-factors
#3
Ignatius Bima Prasetya, Irsan Hasan, Wismandari Wisnu, Cleopas Martin Rumende
BACKGROUND: the risk of Non-Alcoholic Fatty Liver Disease (NAFLD) is increasing in patients with type-2 diabetes. Prevalence and factors related to the increased risk of NAFLD in diabetic patients in Indonesia has never been studied before. Data regarding the profile of fibrosis in the population has also been unknown. This study aimed to identify the difference on the profile of diabetic patients with and without NAFLD as well as the degree of fibrosis. METHODS: the study was conducted using a cross-sectional method in type-2 diabetic patients who were treated at the outpatient clinic of endocrinology and metabolic division in Cipto Mangunkusumo Hospital...
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28789631/efficacy-of-glutathione-for-the-treatment-of-nonalcoholic-fatty-liver-disease-an-open-label-single-arm-multicenter-pilot-study
#4
Yasushi Honda, Takaomi Kessoku, Yoshio Sumida, Takashi Kobayashi, Takayuki Kato, Yuji Ogawa, Wataru Tomeno, Kento Imajo, Koji Fujita, Masato Yoneda, Koshi Kataoka, Masataka Taguri, Takeharu Yamanaka, Yuya Seko, Saiyu Tanaka, Satoru Saito, Masafumi Ono, Satoshi Oeda, Yuichiro Eguchi, Wataru Aoi, Kenji Sato, Yoshito Itoh, Atsushi Nakajima
BACKGROUND: Glutathione plays crucial roles in the detoxification and antioxidant systems of cells and has been used to treat acute poisoning and chronic liver diseases by intravenous injection. This is a first study examining the therapeutic effects of oral administration of glutathione in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: The study was an open label, single arm, multicenter, pilot trial. Thirty-four NAFLD patients diagnosed using ultrasonography were prospectively evaluated...
August 8, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28776387/the-baveno-vi-criteria-for-predicting-esophageal-varices-validation-in-real-life-practice
#5
Mafalda Sousa, Sónia Fernandes, Luísa Proença, Ana Paula Silva, Sónia Leite, Joana Silva, Ana Ponte, Jaime Rodrigues, João Carlos Silva, João Carvalho
BACKGROUND AND AIMS: According to the Baveno VI consensus, patients with liver stiffness < 20 kPa and a platelet count > 150,000 ul have very low risk of clinically significant varices and do not need a screening endoscopy. The aim of this study was to evaluate non-invasive methods as predictors of esophageal varices according to the Baveno VI recommendations, in real life clinical practice. METHODS: Retrospective evaluation of patients with chronic liver disease who underwent transient elastography between January 2013 and December 2015...
August 4, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28772340/inverse-relationship-between-hepatic-steatosis-and-hepatitis-b-viremia-results-of-a-large-case-control-study
#6
Rex Wh Hui, Wai-Kay Seto, Ka-Shing Cheung, Lung-Yi Mak, Kevin Sh Liu, James Fung, Danny Ka-Ho Wong, Ching-Lung Lai, Man-Fung Yuen
The potential interaction between chronic hepatitis B (CHB) and non-alcoholic fatty liver disease (NAFLD), two of the most prevalent liver diseases worldwide, has not been well-defined. We performed liver stiffness (LS) and controlled attenuation parameter (CAP) measurements using transient elastography in 1202 CHB patients. Of these, 601 steatotic patients were matched with non-steatotic controls in a 1:1 ratio by age, gender, nucleoside analogue treatment status, and treatment duration. Severe fibrosis was defined according to EASL-ALEH criteria, and steatosis defined as CAP ≥222 dB m(-1) ...
August 3, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28765697/eight-week-ledipasvir-sofosbuvir-in-non-cirrhotic-treatment-na%C3%A3-ve-hepatitis-c-genotype-1-patients-with-hepatitis-c-virus-rna-6-million-single-center-real-world-effectiveness-and-safety
#7
Nyan L Latt, Beshoy T Yanny, Derenik Gharibian, Rita Gevorkyan, Amandeep K Sahota
AIM: To evaluate sustained viral response (SVR) of 8-wk ledipasvir/sofosbuvir therapy among non-cirrhotic, genotype-1 hepatitis C virus (HCV) patients with RNA < 6 million IU/mL. METHODS: We performed a retrospective cohort study to examine SVR rates, predictors of treatment failure and safety analysis of 8-wk ledipasvir/sofosbuvir (LDV/SOF) therapy among non-cirrhotic, genotype 1 HCV patients with viral load < 6 million IU/mL. Primary outcome was an achievement of SVR at 12 wk after treatment...
July 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28759632/significant-liver-fibrosis-assessed-using-liver-transient-elastography-is-independently-associated-with-low-bone-mineral-density-in-patients-with-non-alcoholic-fatty-liver-disease
#8
Gyuri Kim, Kwang Joon Kim, Yumie Rhee, Sung-Kil Lim
BACKGROUND: Metabolic bone disorders frequently occur in patients with chronic liver disease; however, the association between liver fibrosis and bone mineral density in patients with non-alcoholic fatty liver disease (NAFLD) is unclear. METHODS: This is a cross-sectional analysis of 231 asymptomatic subjects (160 women, 61.6 years old) from a university hospital setting, between February 2012 and December 2014. Bone mineral density (BMD) was measured at the lumbar spine, femur neck, and total hip using dual-energy X-ray absorptiometry (DXA)...
2017: PloS One
https://www.readbyqxmd.com/read/28750503/protein-and-vitamin-b6-intake-are-associated-with-liver-steatosis-assessed-by-transient-elastography-especially-in-obese-individuals
#9
Yvelise Ferro, Ilaria Carè, Elisa Mazza, Francesco Provenzano, Carmela Colica, Carlo Torti, Stefano Romeo, Arturo Pujia, Tiziana Montalcini
Background/Aims: Although the detrimental effects of several dietary components on the promotion of nonalcoholic fatty liver disease are well known, no studies have assessed the role of dietary vitamin B6. Moreover, studies on the associations between dietary components or body composition indices and liver steatosis assessed by transient elastography are rare. Our aim was to identify the nutritional factors and anthropometric parameters associated with liver steatosis. Methods: In this cross-sectional study, we enrolled 168 individuals (35% obese) who underwent a liver steatosis assessment by Controlled Attenuation Parameter measurement and nutritional assessment...
July 28, 2017: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/28723710/controlled-attenuation-parameter-and-mr-spectroscopy-measured-liver-steatosis-are-discordant-in-hiv-infected-adults-with-high-body-mass
#10
Jennifer C Price, Jennifer L Dodge, Yifei Ma, Rebecca Scherzer, Natalie Korn, Kyle Tillinghast, Marion G Peters, Susan Noworolski, Phyllis C Tien
OBJECTIVE: Hepatic steatosis (HS) is common in HIV-infected individuals. Magnetic resonance spectroscopy (MRS) is the preferred non-invasive method for HS measurement but is expensive. Controlled attenuation parameter (CAP) also assesses HS and is conveniently performed concomitantly with transient elastography. We aimed to assess the accuracy of CAP in the setting of HIV infection. DESIGN: Cross-sectional study. METHODS: CAP and MRS were performed in 82 subjects (39 HIV-monoinfected;7 HCV-monoinfected;21 HIV/HCV-coinfected; 15 with neither infection)...
July 18, 2017: AIDS
https://www.readbyqxmd.com/read/28715086/optimal-use-of-transient-elastography-and-acoustic-radiation-force-impulse-to-stage-liver-fibrosis-in-hiv-hcv-coinfected-patients-in-clinical-practice
#11
Juan José López, Núria Pérez-Àlvarez, Raul V Rodríguez, Antoni Jou, Pere Carbonell, José A Jiménez, Laura Soldevila, Montserrat Tenesa, Jordi Tor, Bonaventura Clotet, Jordi Bechini, Cristina Tural
OBJECTIVES: Liver fibrosis (LF) is crucial for the individualized management of patients with hepatitis C virus (HCV). We evaluated the concordance between two noninvasive methods for staging LF, transient elastography (TE) and acoustic radiation force impulse (ARFI), in patients coinfected with human immunodeficiency virus and HCV. We propose an algorithm for optimal use of both techniques in routine clinical practice. METHODS: A total of 89 human immunodeficiency virus/HCV-coinfected patients underwent TE and ARFI on the same day...
July 17, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28711320/liver-stiffness-measurement-by-transient-elastography-predicts-late-posthepatectomy-outcomes-in-patients-undergoing-resection-for-hepatocellular-carcinoma
#12
Muthukumarassamy Rajakannu, Daniel Cherqui, Oriana Ciacio, Nicolas Golse, Gabriella Pittau, Marc Antoine Allard, Teresa Maria Antonini, Audrey Coilly, Antonio Sa Cunha, Denis Castaing, Didier Samuel, Catherine Guettier, René Adam, Eric Vibert
BACKGROUND: Postoperative hepatic decompensation is a serious complication of liver resection in patients undergoing hepatectomy for hepatocellular carcinoma. Liver fibrosis and clinical significant portal hypertension are well-known risk factors for hepatic decompensation. Liver stiffness measurement is a noninvasive method of evaluating hepatic venous pressure gradient and functional hepatic reserve by estimating hepatic fibrosis. Effectiveness of liver stiffness measurement in predicting persistent postoperative hepatic decompensation has not been investigated...
July 12, 2017: Surgery
https://www.readbyqxmd.com/read/28704381/sofosbuvir-based-treatment-of-chronic-hepatitis-c-genotype-3-infections-a-scandinavian-real-life-study
#13
Olav Dalgard, Ola Weiland, Geir Noraberg, Lars Karlsen, Lars Heggelund, Martti Färkkilâ, Ulla Balslev, Erika Belard, Anne Øvrehus, Mette Skalshøi Kjær, Henrik Krarup, Birgit Thorup Røge, Sofie Hallager, Lone G Madsen, Alex Lund Laursen, Martin Lagging, Nina Weis
BACKGROUND AND AIMS: Chronic hepatitis C virus (HCV) genotype 3 infection with advanced liver disease has emerged as the most challenging to treat. We retrospectively assessed the treatment outcome of sofosbuvir (SOF) based regimes for treatment of HCV genotype 3 infections in a real life setting in Scandinavia. METHODS: Consecutive patients with chronic HCV genotype 3 infection were enrolled at 16 treatment centers in Denmark, Sweden, Norway and Finland. Patients who had received a SOF containing regimen were included...
2017: PloS One
https://www.readbyqxmd.com/read/28703905/successful-treatment-of-chronic-hepatitis-c-infection-with-directly-acting-antivirals-in-renal-transplant-recipients
#14
Sunil Taneja, Ajay Duseja, Arka De, Vivek Kumar, Raja Ramachandran, Ashish Sharma, Radha K Dhiman, Krishan L Gupta, Yogesh Chawla
AIMS: The data regarding the treatment of chronic hepatitis C (CHC) in renal transplant recipients is lacking from the Asia-Pacific region. Aim of the present study was to assess the safety and efficacy of directly acting antivirals (DAAs) in the treatment of CHC infection in renal transplant recipients. METHODS: A total of 47 CHC infected renal transplant recipients were enrolled in this real life observational cohort analysis between March 2015 and September 2016...
July 13, 2017: Nephrology
https://www.readbyqxmd.com/read/28701893/risk-assessment-of-hepatocellular-carcinoma-in-general-population-by-liver-stiffness-in-combination-with-controlled-attenuation-parameter-using-transient-elastography-a-cross-sectional-study
#15
Takaaki Sugihara, Masahiko Koda, Tomomitsu Matono, Kinya Okamoto, Yoshikazu Murawaki, Hajime Isomoto, Shiho Tokunaga
BACKGROUND: Hepatocellular carcinoma (HCC) in patients without hepatitis B (HBV) and -C virus (HCV) infection are increasing in Japan. Method for detecting high-risk liver diseases of HCC in general population has still not been established. Liver stiffness measurement (LSM) and Controlled Attenuation Parameter (CAP) using transient elastography (TE; FibroScan System) are useful for detecting liver fibrosis and steatosis. The aim of this study is to clarify TE for risk assessment of HCC in general population...
June 2017: Yonago Acta Medica
https://www.readbyqxmd.com/read/28688902/serum-s100-calcium-binding-protein-a4-improves-the-diagnostic-accuracy-of-transient-elastography-for-assessing-liver-fibrosis-in-hepatitis-b
#16
Li-Bo Yan, Qing-Bo Zhang, Xia Zhu, Min He, Hong Tang
AIM: The diagnostic performance of Fibroscan might be improved when combined with other serum fibrosis related markers. Previous study has demonstrated that S100A4 expression is associated with liver fibrosis in humans with hepatitis. This study aimed to clarify diagnostic accuracy of serum S100A4 levels for significant liver fibrosis in patients with chronic hepatitis B (CHB), and develop a combined algorithm of liver stiffness measurement (LSM) and S100A4 to predict significant liver fibrosis in CHB...
July 5, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28688190/improvement-of-glycemic-state-among-responders-to-sofosbuvir-based-treatment-regimens-single-center-experience
#17
Shereen Abdel Alem, Aisha Elsharkawy, Rabab Fouad, Eman Adel, Zeinab Abdellatif, Sherief Musa, Ahmed Nagy, Muhammad S Hussein, Ayman Yosry, Gamal Esmat
BACKGROUND: Chronic HCV infection has emerged as a complex multifaceted disease with manifestations extending beyond the liver. HCV plays a direct role in glucose metabolism leading to both insulin resistance and type 2 diabetes. AIMS: To evaluate the changes in the glycemic state following Sofosbuvir-based treatment regimens in diabetic HCV patients. METHODS: Four hundred chronic hepatitis C patients who underwent Sofosbuvir-based treatment regimens were retrospectively screened...
July 8, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28679676/economic-evaluation-of-a-community-based-diagnostic-pathway-to-stratify-adults-for-non-alcoholic-fatty-liver-disease-a-markov-model-informed-by-a-feasibility-study
#18
Lukasz Tanajewski, Rebecca Harris, David J Harman, Guruprasad P Aithal, Timothy R Card, Georgios Gkountouras, Vladislav Berdunov, Indra N Guha, Rachel A Elliott
OBJECTIVES: To assess the long-term cost-effectiveness of a risk stratification pathway, compared with standard care, for detecting non-alcoholic fatty liver disease (NAFLD) in primary care. SETTING: Primary care general practices in England. PARTICIPANTS: Adults who have been identified in primary care to have a risk factor for developing NAFLD, that is, type 2 diabetes without a history of excessive alcohol use. INTERVENTION: A community-based pathway, which uses transient elastography and hepatologists to stratify patients at risk of NAFLD, has been implemented and demonstrated to be feasible (NCT02037867)...
July 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28674631/liver-stiffness-assessed-by-fibrosis-4-index-predicts-mortality-in-patients-with-heart-failure
#19
Yu Sato, Akiomi Yoshihisa, Yuki Kanno, Shunsuke Watanabe, Tetsuro Yokokawa, Satoshi Abe, Tomofumi Misaka, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Shu-Ichi Saitoh, Yasuchika Takeishi
OBJECTIVE: Liver dysfunction due to heart failure (HF) is known as congestive hepatopathy. It has recently been reported that liver stiffness assessed by transient elastography reflects increased central venous pressure. The Fibrosis-4 (FIB4) index (age (years) × aspartate aminotransferase (IU/L)/platelet count (10(9)/L) × square root of alanine aminotransferase (IU/L)) is expected to be useful for evaluating liver stiffness in patients with non-alcoholic fatty liver disease. We aimed to investigate the impact of the FIB4 index on HF prognosis, with consideration for liver fibrosis markers and underlying cardiac function...
2017: Open Heart
https://www.readbyqxmd.com/read/28673437/-i-didn-t-want-to-let-it-go-too-far-the-decisions-and-experiences-of-people-who-inject-drugs-who-received-a-liver-disease-assessment-as-part-of-a-liver-health-promotion-campaign-the-liverlife-study
#20
Alison D Marshall, Jason Grebely, Gregory J Dore, Carla Treloar
BACKGROUND: An open cohort study (LiveRLife) evaluating an intervention integrating non-invasive liver disease assessment via transient elastography (TE) among people who inject drugs (PWID) was conducted in New South Wales, Australia. Participant follow-up occurred 2-16 weeks post-enrolment. It is imperative that PWID understand liver assessment results in order to make informed decisions about their health. The aim of this study was to evaluate the decisions and experiences of participants who received a liver disease assessment, including interpretation of TE score and subsequent health behaviours, using a health literacy framework...
June 30, 2017: International Journal on Drug Policy
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