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transient elastography

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https://www.readbyqxmd.com/read/28548237/simulation-of-non-linear-transient-elastography-finite-element-model-for-the-propagation-of-shear-waves-in-homogeneous-soft-tissues
#1
W Ye, A Bel-Brunon, S Catheline, A Combescure, M Rochette
In this study, visco-hyperelastic Landau's model which is widely used in acoustical physic field is introduced into a finite element formulation. It is designed to model the non-linear behaviour of finite amplitude shear waves in soft solids, typically, in biological tissues. This law is employed in finite element models based on elastography experiments reported in [1], the simulations results show a good agreement with the experimental studyred: it is observed in both that a plane shear wave generates only odd harmonics and a nonplane wave generates both odd and even harmonics in the spectral domain...
May 26, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28544232/peripartum-cytokine-flares-in-a-multiethnic-cohort-of-chronic-hepatitis-b-carriers-does-not-correlate-with-hepatitis-b-virus-suppression-or-increased-risk-of-liver-disease
#2
Shivali S Joshi, Daniel Wong, Eliana Castillo, Mark G Swain, Carla S Coffin
PROBLEM: In chronic hepatitis B (CHB) carriers, alanine transaminase (ALT) flares are common in the peripartum period. There are limited data on immunological changes of pregnancy in CHB. We hypothesize that in pregnant CHB carriers, the Th1/Th2 cytokine ratio is altered resulting in changes in biochemical/virological and liver fibrosis markers. STUDY METHODS: Serum from 38 pregnant/post-partum CHB carriers (median age 32 years, 53% Asian, 8 HBeAg(+) ) was tested for HBV DNA, quantitative HBV surface antigen, ALT and liver fibrosis by transient elastography (TE)...
May 19, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28532285/utility-of-transient-elastography-in-estimating-hepatic-iron-concentration-in-comparison-to-magnetic-resonance-imaging-in-patients-who-are-transfusion-dependent-a-canadian-center-experience
#3
George Ou, Hin Hin Ko, Pari Tiwari, Navdeep Sandhu, Cherry Galorport, Terry Lee, Hatoon Ezzat
Transfusion-dependent hereditary anemias such as β-thalassemia (β-thal), predispose patients to iron overload and its numerous clinical sequelae. Accurate assessment of overall iron status and prompt initiation of chelation therapy to prevent irreversible end-organ damage can be achieved using magnetic resonance imaging (MRI) to measure liver iron concentration (LIC) as a surrogate marker of total body iron; however, its access may be associated with long wait times and delay in treatment. We report an observational cohort study at a single tertiary care center assessing the theoretical role of transient elastography (TE), which measures liver stiffness, in estimating LIC compared to other established diagnostic measures...
January 2017: Hemoglobin
https://www.readbyqxmd.com/read/28527666/hepatic-steatosis-progresses-faster-in-hiv-mono-infected-than-hiv-hcv-co-infected-patients-and-is-associated-with-liver-fibrosis
#4
Thomas Pembroke, Marc Deschenes, Bertrand Lebouché, Amine Benmassaoud, Maida Sewitch, Peter Ghali, Philip Wong, Alex Halme, Elise Vuille-Lessard, Costa Pexos, Marina B Klein, Giada Sebastiani
BACKGROUND & AIMS: Hepatic steatosis (HS) seems common in patients infected with human immunodeficiency virus (HIV). However, the relative effect of HIV, as well as hepatitis C virus (HCV) in those co-infected, and the influence of HS on liver fibrosis progression are unclear. METHODS: The LIVEr disease in HIV (LIVEHIV) is a Canadian prospective Cohort using transient elastography and associated controlled attenuation parameter (CAP) to screen for HS and liver fibrosis in unselected HIV-infected adults...
May 17, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28523578/prevalence-and-predictors-of-significant-fibrosis-among-subjects-with-transient-elastography-defined-nonalcoholic-fatty-liver-disease
#5
Hye Won Lee, Beom Kyung Kim, Seung Up Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang Joon Kim, Kwang-Hyub Han
BACKGROUND/AIMS: Transient elastography (TE) can be used to assess the degree of liver fibrosis and steatosis. We investigated the prevalence and predictors of nonalcoholic fatty liver disease (NAFLD) with or without significant liver fibrosis in the general population. METHODS: A total of 3033 subjects without alcoholic or chronic viral liver diseases who underwent a medical health check-up including TE were recruited from April 2013 to August 2014. TE-defined NAFLD was defined as a controlled attenuation parameter of ≥250 dB/m, and significant liver fibrosis was defined as a liver stiffness (LS) value of ≥8 kPa...
May 18, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28521774/correlation-of-cell-free-dna-plasma-concentration-with-severity-of-non-alcoholic-fatty-liver-disease
#6
Thomas Karlas, Lara Weise, Stephanie Kuhn, Felix Krenzien, Matthias Mehdorn, David Petroff, Nicolas Linder, Alexander Schaudinn, Harald Busse, Volker Keim, Johann Pratschke, Johannes Wiegand, Katrin Splith, Moritz Schmelzle
BACKGROUND: The assessment of fibrosis and inflammatory activity is essential to identify patients with non-alcoholic fatty liver disease (NAFLD) at risk for progressive disease. Serum markers and ultrasound-based methods can replace liver biopsy for fibrosis staging, whereas non-invasive characterization of inflammatory activity remains a clinical challenge. Cell-free DNA (cfDNA) is a novel non-invasive biomarker for assessing cellular inflammation and cell death, which has not been evaluated in NAFLD...
May 19, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28516045/exploration-of-highly-accelerated-magnetic-resonance-elastography-using-high-density-array-coils
#7
John C Bosshard, Naresh Yallapragada, Mary P McDougall, Steven M Wright
BACKGROUND: Magnetic resonance elastography (MRE) measures tissue mechanical properties by applying a shear wave and capturing its propagation using magnetic resonance imaging (MRI). By using high density array coils, MRE images are acquired using single echo acquisition (SEA) and at high resolutions with significantly reduced scan times. METHODS: Sixty-four channel uniplanar and 32×32 channel biplanar receive arrays are used to acquire MRE wave image sets from agar samples containing regions of varying stiffness...
April 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28506907/validity-criteria-for-the-diagnosis-of-fatty-liver-by-m-probe-based-controlled-attenuation-parameter
#8
Vincent Wai-Sun Wong, Salvatore Petta, Jean-Baptiste Hiriart, Calogero Cammà, Grace Lai-Hung Wong, Fabio Marra, Julien Vergniol, Anthony Wing-Hung Chan, Antonino Tuttolomondo, Wassil Merrouche, Henry Lik-Yuen Chan, Brigitte Le Bail, Umberto Arena, Antonio Craxì, Victor de Lédinghen
BACKGROUND & AIMS: Controlled attenuation parameter (CAP) can be performed together with liver stiffness measurement (LSM) by transient elastography and is often used to diagnose fatty liver. We aimed to define the validity criteria of CAP. METHODS: CAP was measured by the M probe prior to liver biopsy in 754 consecutive patients with different liver diseases at 3 centres in Europe and Hong Kong (derivation cohort, n=340; validation cohort, n=414; 101 chronic hepatitis B, 154 chronic hepatitis C, 349 non-alcoholic fatty liver disease, 37 autoimmune hepatitis, 49 cholestatic liver disease, 64 others; 277 F3-4; age 52±14; body mass index 27...
May 12, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28503746/application-of-ultrasound-elastography-for-chronic-allograft-dysfunction-in-kidney-transplantation
#9
REVIEW
Zijie Wang, Haiwei Yang, Chuanjian Suo, Jifu Wei, Ruoyun Tan, Min Gu
Interstitial fibrosis is the main characteristic of chronic allograft dysfunction, which remains the key factor affecting long-term allograft survival after kidney transplantation. Ultrasound elastography (UE), including real-time elastography, transient elastography, and acoustic radiation force impulse, has been applied widely in breast, thyroid, and liver diseases, especially in the assessment of liver fibrosis. Recently, numerous studies have reported the efficacy of UE methods in evaluating renal allograft fibrosis...
May 15, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28493799/shear-wave-elastography-basic-physics-and-musculoskeletal-applications
#10
Mihra S Taljanovic, Lana H Gimber, Giles W Becker, L Daniel Latt, Andrea S Klauser, David M Melville, Liang Gao, Russell S Witte
In the past 2 decades, sonoelastography has been progressively used as a tool to help evaluate soft-tissue elasticity and add to information obtained with conventional gray-scale and Doppler ultrasonographic techniques. Recently introduced on clinical scanners, shear-wave elastography (SWE) is considered to be more objective, quantitative, and reproducible than compression sonoelastography with increasing applications to the musculoskeletal system. SWE uses an acoustic radiation force pulse sequence to generate shear waves, which propagate perpendicular to the ultrasound beam, causing transient displacements...
May 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28493426/optical-coherence-elastography-for-strain-dynamics-measurements-in-laser-correction-of-cornea-shape
#11
Vladimir Y Zaitsev, Alexander L Matveyev, Lev A Matveev, Grigory V Gelikonov, Alexander I Omelchenko, Olga I Baum, Sergey E Avetisov, Andrey V Bolshunov, Vladimir I Siplivy, Dmitry V Shabanov, Alex Vitkin, Emil N Sobol
We describe the use of elastographic processing in phase-sensitive optical coherence tomography (OCT) for visualizing dynamics of strain and tissue-shape changes during laser-induced photothermal corneal reshaping, for applications in the emerging field of non-destructive and non-ablative (non-LASIK) laser vision correction. The proposed phase-processing approach based on fairly sparse data acquisition enabled rapid data processing and near-real-time visualization of dynamic strains. The approach avoids conventional phase unwrapping, yet allows for mapping strains even for significantly supra-wavelength inter-frame displacements of scatterers accompanied by multiple phase-wrapping...
May 11, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28483579/comparison-of-2-d-shear-wave-elastography-and-transient-elastography-for-assessing-liver-fibrosis-in-chronic-hepatitis-b
#12
Jie Zeng, Jian Zheng, Zeping Huang, Shigao Chen, Jing Liu, Tao Wu, Rongqin Zheng, Mingde Lu
This study compared 2-D shear wave elastography (SWE) and transient elastography (TE) for liver fibrosis staging in patients with chronic hepatitis B (CHB) infection using liver biopsy as the reference standard. Patients with CHB infection who underwent liver biopsy were consecutively included. After exclusions, 257 patients were analyzed. Two-dimensional SWE resulted in a significantly higher rate of reliable measurements (98.1%, 252/257) than TE (93.0%, 239/257) (p = 0.011). Liver stiffness measurements of the two examinations exhibited a strong correlation (r = 0...
May 5, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28481460/high-efficacy-of-sofosbuvir-plus-simeprevir-in-a-large-cohort-of-spanish-cirrhotic-patients-infected-with-genotypes-1-and-4
#13
Zoe Mariño, Juan Manuel Pascasio-Acevedo, Adolfo Gallego, Moisés Diago, Carme Baliellas, Rosa Morillas, Martín Prieto, José María Moreno, Gloria Sánchez-Antolín, Mercedes Vergara, Montserrat Forné, Inmaculada Fernández, Maria Ángeles Castro, Sonia Pascual, Alexandra Gómez, Lluis Castells, Jose Luis Montero, Javier Crespo, Jose Luis Calleja, Javier García-Samaniego, Jose Antonio Carrión, Ana Del Carmen Arencibia, Alejandro Blasco, Carmen López-Núñez, Juan José Sánchez-Ruano, Francisco Gea-Rodríguez, Álvaro Giráldez, Joaquín Cabezas, Vanessa Hontangas, Xavier Torras, Jose Castellote, Manuel Romero-Gómez, Juan Turnes, Tomás de Artaza, Isidoro Narváez, Valentín Cuervas-Mons, Xavier Forns
BACKGROUND AND AIMS: Hepatitis C (HCV) therapy with Sofosbuvir(SOF)/ Simeprevir(SMV) in clinical trials and real-world clinical practice, showed high rates of sustained virological response (SVR) in non-cirrhotic genotype(GT)-1 and 4 patients. These results were slightly lower in cirrhotic patients. We investigated real-life effectiveness and safety of SOF/SMV with or without ribavirin(RBV) in a large cohort of cirrhotic patients. METHODS: This collaborative multicentre study included data from 968 patients with cirrhosis infected with HCV-GT1 or 4, treated with SOF/SMV±RBV in 30 centres across Spain between January-2014 and December-2015...
May 8, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28480856/comparative-study-of-fib-4-index-and-transient-elastography-among-patients-with-chronic-hepatitis-c-virus-infection-in-georgia
#14
E Dolmazashvili, M Karchava, A Abutidze, L Sharvadze, T Tsertsvadze
Liver biopsy remains the reference standard for fibrosis staging. However, it has several limitations, which have led to the development of non-invasive methods. We evaluated liver fibrosis severity among HCV infected patients by comparing transient elastography (TE) and FIB-4 index. Retrospective study was conducted. Clinical data for 750 patients were obtained. The mean age of the study population was 51 years; 595 (79.3%) were male and 155 (20.7%) were female. TE and tests on biological samples were performed within one-week timeframe...
March 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28479902/low-sero-prevalence-of-hepatitis-delta-antibodies-in-hiv-hepatitis-b-co-infected-patients-attending-an-urban-hiv-clinic-in-uganda
#15
Elizabeth Katwesigye, Emmanuel Seremba, Fred Semitala, Ponsiano Ocama
BACKGROUND: Co-infection with hepatitis B (HBV) and hepatitis D (HDV) is common among human immunodeficiency virus (HIV) infected individuals in developing countries and it aggressively accelerates progression of liver disease to cirrhosis and other complications. There is scarcity of data on HDV in sub-Saharan Africa .We investigated the sero-prevalence and factors associated with HDV antibody among HIV/HBV co-infected patients attending a large urban HIV clinic in Uganda. METHODS: We screened 189 HIV/HBV co-infected individuals for anti-HDV immunoglobulin G (IgG) and performed logistic regression to determine the associated factors...
December 2016: African Health Sciences
https://www.readbyqxmd.com/read/28473066/acr-appropriateness-criteria-%C3%A2-chronic-liver%C3%A2-disease
#16
Jeanne M Horowitz, Ihab R Kamel, Hina Arif-Tiwari, Sumeet K Asrani, Nicole M Hindman, Harmeet Kaur, Michelle M McNamara, Richard B Noto, Aliya Qayyum, Tasneem Lalani
Because liver fibrosis can be treated, it is important to diagnose liver fibrosis noninvasively and monitor response to treatment. Although ultrasound (grayscale and Doppler) can diagnose cirrhosis, it does so unreliably using morphologic and sonographic features and cannot diagnose the earlier, treatable stages of hepatic fibrosis. Transient elastography, ultrasound elastography with acoustic radiation force impulse, and MR elastography are modalities that can assess for hepatic fibrosis. Although all international organizations recommend ultrasound for screening for hepatocellular carcinoma, ultrasound is particularly limited for identifying hepatocellular carcinoma in patients with obesity, nonalcoholic fatty liver disease, and nodular cirrhotic livers...
May 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28464883/late-presentation-of-chronic-viral-hepatitis-for-medical-care-a-consensus-definition
#17
Stefan Mauss, Stanislas Pol, Maria Buti, Erika Duffell, Charles Gore, Jeffrey V Lazarus, Hilje Logtenberg-van der Grient, Jens Lundgren, Antons Mozalevskis, Dorthe Raben, Eberhard Schatz, Stefan Wiktor, Jürgen K Rockstroh
INTRODUCTION: We present two consensus definitions of advanced and late stage liver disease being used as epidemiological tools. These definitions can be applied to assess the morbidity caused by liver diseases in different health care systems. We focus is on hepatitis B and C virus infections, because effective and well tolerated treatments for both of these infections have greatly improved our ability to successfully treat and prevent advanced and late stage disease, especially if diagnosed early...
May 3, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28464257/significant-positive-association-of-endotoxemia-with-histological-severity-in-237-patients-with-non-alcoholic-fatty-liver-disease
#18
J Pang, W Xu, X Zhang, G L-H Wong, A W-H Chan, H-Y Chan, C-H Tse, S S-T Shu, P C-L Choi, H L-Y Chan, J Yu, V W-S Wong
BACKGROUND: Patients with nonalcoholic steatohepatitis (NASH) have gut dysbiosis and intestinal bacterial overgrowth. AIM: To test the hypothesis that endotoxemia is associated with the histological severity of nonalcoholic fatty liver disease (NAFLD) and determine factors associated with endotoxemia. METHODS: The endotoxemia markers lipopolysaccharide-binding protein (LBP) and endotoxin levels were measured in 237 NAFLD patients 1 day before liver biopsy...
May 2, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28452125/stepwise-application-of-fib-4-red-cell-distribution-width-platelet-ratio-and-apri-for-compensated-hepatitis-b-fibrosis-detection
#19
Yong-Peng Chen, Xiao-Min Hu, Xie-Er Liang, Li-Wen Huang, You-Fu Zhu, Jin-Lin Hou
AIM: FIB-4 and APRI were validated with unsatisfactory efficiency. Routine hematology in-dex red cell distribution width-platelet ratio (RPR) had been tried in Liver Fibrosis detection. This study tries to evaluate the stepwise application of FIB-4, RPR and APRI in detecting CHB fibrosis. METHODS: A total of 246 compensated CHB patients underwent liver biopsies, transient elas-tography and routine blood tests including complete blood count were included. Dual Cutoffs were determined to exclude or include cirrhosis diagnosis...
April 28, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28450959/changes-in-liver-stiffness-and-its-associated-factors-during-oral-antiviral-therapy-in-chinese-patients-with-chronic-hepatitis-b
#20
Xu Li, Qinglong Jin, Hong Zhang, Xue Jing, Zhongyang Ding, Hongjie Zhou, Zetian Zhang, Dongqing Yan, Dongmei Li, Pujun Gao, Junqi Niu
The present study aimed to assess improvements in liver stiffness determined by transient elastography and associated factors in Chinese patients with chronic hepatitis B (CHB) during long-term treatment with oral antiviral drugs. A total of 334 consecutive Chinese patients with CHB who underwent oral antiviral therapy and received at least two liver stiffness measurements (LSMs) at the First Hospital of Jilin University (Changchun, China) from December 2012 to February 2015 were enrolled in the present study...
March 2017: Experimental and Therapeutic Medicine
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